Nothing Special   »   [go: up one dir, main page]

SG11201700828PA - Cationic lipid - Google Patents

Cationic lipid

Info

Publication number
SG11201700828PA
SG11201700828PA SG11201700828PA SG11201700828PA SG11201700828PA SG 11201700828P A SG11201700828P A SG 11201700828PA SG 11201700828P A SG11201700828P A SG 11201700828PA SG 11201700828P A SG11201700828P A SG 11201700828PA SG 11201700828P A SG11201700828P A SG 11201700828PA
Authority
SG
Singapore
Prior art keywords
cationic lipid
lipid
cationic
Prior art date
Application number
SG11201700828PA
Inventor
Yasutaka Hoashi
Original Assignee
Takeda Pharmaceuticals Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceuticals Co filed Critical Takeda Pharmaceuticals Co
Publication of SG11201700828PA publication Critical patent/SG11201700828PA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/34Esters of acyclic saturated polycarboxylic acids having an esterified carboxyl group bound to an acyclic carbon atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/7105Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/713Double-stranded nucleic acids or oligonucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/12Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11CFATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
    • C11C3/00Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom
    • C11C3/003Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom by esterification of fatty acids with alcohols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Liposomes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/14Type of nucleic acid interfering N.A.
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00Applications; Uses
    • C12N2320/30Special therapeutic applications
    • C12N2320/32Special delivery means, e.g. tissue-specific

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Wood Science & Technology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Optics & Photonics (AREA)
  • Nanotechnology (AREA)
  • Plant Pathology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SG11201700828PA 2014-08-07 2015-08-06 Cationic lipid SG11201700828PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2014161718 2014-08-07
PCT/JP2015/072344 WO2016021683A1 (en) 2014-08-07 2015-08-06 Cationic lipid

Publications (1)

Publication Number Publication Date
SG11201700828PA true SG11201700828PA (en) 2017-03-30

Family

ID=55263940

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201700828PA SG11201700828PA (en) 2014-08-07 2015-08-06 Cationic lipid

Country Status (12)

Country Link
US (1) US10252974B2 (en)
EP (1) EP3178807B1 (en)
JP (1) JP6587619B2 (en)
KR (1) KR101882634B1 (en)
CN (1) CN106573877B (en)
AU (1) AU2015300046B2 (en)
CA (1) CA2956554C (en)
ES (1) ES2799409T3 (en)
IL (1) IL250236B (en)
PL (1) PL3178807T3 (en)
SG (1) SG11201700828PA (en)
WO (1) WO2016021683A1 (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2616051T3 (en) 2008-12-02 2017-06-09 Wave Life Sciences Japan, Inc. Method for the synthesis of modified nucleic acids in the phosphorus atom
US9744183B2 (en) 2009-07-06 2017-08-29 Wave Life Sciences Ltd. Nucleic acid prodrugs and methods of use thereof
EP2620428B1 (en) 2010-09-24 2019-05-22 Wave Life Sciences Ltd. Asymmetric auxiliary group
KR20140068884A (en) 2011-07-19 2014-06-09 웨이브 라이프 사이언시스 피티이. 리미티드 Methods for the synthesis of functionalized nucleic acids
JP6268157B2 (en) 2012-07-13 2018-01-24 株式会社Wave Life Sciences Japan Asymmetric auxiliary group
PL3094728T3 (en) 2014-01-16 2022-07-04 Wave Life Sciences Ltd. Chiral design
CA2980721C (en) * 2015-03-24 2023-10-24 Kyowa Hakko Kirin Co., Ltd. Nucleic acid-containing lipid nanoparticles
GB201604235D0 (en) * 2016-03-11 2016-04-27 Ucl Business Plc Lipids and complexes for the delivery of biologically-active material to cells
KR20200104360A (en) * 2017-12-27 2020-09-03 다케다 야쿠힌 고교 가부시키가이샤 Nucleic acid-containing lipid nano-particles and uses thereof
EP3733641B1 (en) 2017-12-28 2024-04-10 Takeda Pharmaceutical Company Limited Cationic lipids
KR20200104318A (en) 2017-12-28 2020-09-03 고쿠리츠 다이가쿠 호진 교토 다이가쿠 Composition for target gene modification
BR112021002384B1 (en) * 2018-08-10 2024-01-23 Takeda Pharmaceutical Company Limited COMPOUND, LIPID PARTICLE, AND, COMPOSITION FOR NUCLEIC ACID TRANSFER
CN112639111B (en) * 2018-08-10 2023-07-21 国立大学法人京都大学 Method for transfecting cardiomyocytes using cationic lipids
JPWO2020080475A1 (en) 2018-10-18 2021-09-30 武田薬品工業株式会社 T cell activation / proliferation method
JPWO2022045334A1 (en) 2020-08-31 2022-03-03
CZ2020529A3 (en) * 2020-09-23 2022-03-30 Ústav organické chemie a biochemie AV ČR, v. v. i. Lipidoids for nucleic acid transfection and their use
CN115197080A (en) * 2021-04-08 2022-10-18 厦门赛诺邦格生物科技股份有限公司 Polyethylene glycol lipid and liposome modified by same, pharmaceutical composition containing liposome, preparation and application of pharmaceutical composition
CN118201905A (en) 2021-11-10 2024-06-14 武田药品工业株式会社 Cationic lipid
CN118742966A (en) 2022-02-28 2024-10-01 武田药品工业株式会社 Inference device, generation device, inference program, and generation program
CN115850135B (en) * 2022-04-29 2023-11-21 喻国灿 Sulfur-containing Janus-type ionizable liposome and application thereof
WO2024121814A1 (en) 2022-12-09 2024-06-13 Takeda Pharmaceutical Company Limited Modified immunomodulators
WO2024200820A1 (en) 2023-03-30 2024-10-03 Ose Immunotherapeutics Method of synthesis of targeted lipid nanoparticle and uses thereof
WO2024200823A1 (en) 2023-03-30 2024-10-03 Ose Immunotherapeutics Lipid-based nanoparticle targeted at activated immune cells for the expression of immune cell enhancing molecule and use thereof
WO2024210160A1 (en) 2023-04-07 2024-10-10 Takeda Pharmaceutical Company Limited Conjugation complex

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6043390A (en) 1998-04-03 2000-03-28 The Regents Of The University Of California Pentaerythritol lipid derivatives and nucleic-acid complexes
KR100822684B1 (en) 2000-10-04 2008-04-17 교와 핫꼬 고교 가부시끼가이샤 Method of coating fine particle with lipid film
US20040043952A1 (en) 2002-05-31 2004-03-04 Genteric, Inc. Multifunctional polyamines for delivery of biologically-active polynucleotides
JP2009023972A (en) * 2007-07-23 2009-02-05 Fujifilm Corp Branched chain higher fatty acid diester derivative having diethylene triamine type metal chelate structure
MX359674B (en) 2008-11-10 2018-10-05 Alnylam Pharmaceuticals Inc Novel lipids and compositions for the delivery of therapeutics.
CN101780286A (en) * 2009-01-16 2010-07-21 中国人民解放军总医院 Chemotactic factor receptor CXCR4 non-peptide antagonist medicaments for radiodiagnosis and treatment
EP2567951B1 (en) 2010-04-28 2018-09-19 Kyowa Hakko Kirin Co., Ltd. Cationic lipid
CA2800401C (en) 2010-06-03 2020-09-15 Alnylam Pharmaceuticals, Inc. Biodegradable lipids for the delivery of active agents
EP2629802B1 (en) 2010-10-21 2019-12-04 Sirna Therapeutics, Inc. Low molecular weight cationic lipids for oligonucleotide delivery
JP6305343B2 (en) 2011-12-07 2018-04-04 アルニラム・ファーマシューティカルズ・インコーポレーテッド Branched alkyl and cycloalkyl terminated biodegradable lipids for the delivery of active agents
DK3988537T1 (en) * 2011-12-07 2022-05-23 Alnylam Pharmaceuticals Inc BIODEGRADABLE LIPIDES FOR DELIVERY OF ACTIVE AGENTS
AU2013222179B2 (en) * 2012-02-24 2017-08-24 Arbutus Biopharma Corporat ion Trialkyl cationic lipids and methods of use thereof
CN102898549A (en) * 2012-10-09 2013-01-30 长沙新宇高分子科技有限公司 Highly branched macro-molecule photoinitiator and preparation method thereof

Also Published As

Publication number Publication date
EP3178807A4 (en) 2018-03-28
IL250236A0 (en) 2017-03-30
CN106573877A (en) 2017-04-19
PL3178807T3 (en) 2020-08-24
WO2016021683A1 (en) 2016-02-11
IL250236B (en) 2021-04-29
EP3178807A1 (en) 2017-06-14
AU2015300046A1 (en) 2017-02-16
US10252974B2 (en) 2019-04-09
CA2956554C (en) 2022-03-01
KR20170039722A (en) 2017-04-11
JP6587619B2 (en) 2019-10-09
CA2956554A1 (en) 2016-02-11
CN106573877B (en) 2021-04-13
KR101882634B1 (en) 2018-07-26
US20170197903A1 (en) 2017-07-13
ES2799409T3 (en) 2020-12-17
JPWO2016021683A1 (en) 2017-06-08
EP3178807B1 (en) 2020-04-29
AU2015300046B2 (en) 2019-05-09

Similar Documents

Publication Publication Date Title
IL250236A0 (en) Cationic lipid
GB201707959D0 (en) No details
GB201517022D0 (en) No details
EP3252043A4 (en) Cationic lipid
GB201519531D0 (en) No details
GB201410907D0 (en) No details
EP3239132A4 (en) Cationic lipid
GB201517404D0 (en) No details
IL262574B (en) Cationic lipid
GB201418217D0 (en) No details
GB201706130D0 (en) No details
GB201418216D0 (en) No details
EP3093283A4 (en) Cationic lipid
GB201612542D0 (en) no details
GB201615071D0 (en) No details
GB201517412D0 (en) No details
GB201709180D0 (en) No details
GB201517574D0 (en) No details
GB201516796D0 (en) No details
GB201616225D0 (en) No details
EP3162794A4 (en) Cationic lipid
GB201708207D0 (en) No details
GB201517605D0 (en) No details
GB2523362B (en) Turbogenerator
GB201702336D0 (en) No details