Nothing Special   »   [go: up one dir, main page]

SG10201400235PA - Hepatitis c virus inhibitors - Google Patents

Hepatitis c virus inhibitors

Info

Publication number
SG10201400235PA
SG10201400235PA SG10201400235PA SG10201400235PA SG10201400235PA SG 10201400235P A SG10201400235P A SG 10201400235PA SG 10201400235P A SG10201400235P A SG 10201400235PA SG 10201400235P A SG10201400235P A SG 10201400235PA SG 10201400235P A SG10201400235P A SG 10201400235PA
Authority
SG
Singapore
Prior art keywords
hepatitis
virus inhibitors
virus
inhibitors
Prior art date
Application number
SG10201400235PA
Inventor
Yao-Ling Qiu
Ce Wang
Xiaowen Peng
Lu Ying
Yat Sun Or
Original Assignee
Enanta Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enanta Pharm Inc filed Critical Enanta Pharm Inc
Publication of SG10201400235PA publication Critical patent/SG10201400235PA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41841,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
SG10201400235PA 2009-02-27 2010-03-01 Hepatitis c virus inhibitors SG10201400235PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15613109P 2009-02-27 2009-02-27
US15807109P 2009-03-06 2009-03-06

Publications (1)

Publication Number Publication Date
SG10201400235PA true SG10201400235PA (en) 2014-07-30

Family

ID=42665963

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201400235PA SG10201400235PA (en) 2009-02-27 2010-03-01 Hepatitis c virus inhibitors
SG2011060779A SG174146A1 (en) 2009-02-27 2010-03-01 Hepatitis c virus inhibitors

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG2011060779A SG174146A1 (en) 2009-02-27 2010-03-01 Hepatitis c virus inhibitors

Country Status (16)

Country Link
EP (1) EP2400846B1 (en)
JP (2) JP5628841B2 (en)
KR (2) KR101411889B1 (en)
CN (1) CN102427731B (en)
AU (1) AU2010217797B2 (en)
BR (1) BRPI1007836A2 (en)
CA (1) CA2753382C (en)
ES (1) ES2606717T3 (en)
IL (1) IL214775A (en)
MX (1) MX2011008982A (en)
MY (1) MY160130A (en)
NZ (1) NZ595280A (en)
RU (1) RU2544010C2 (en)
SG (2) SG10201400235PA (en)
WO (1) WO2010099527A1 (en)
ZA (1) ZA201106629B (en)

Families Citing this family (116)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2361242B1 (en) 2008-10-17 2018-08-01 Oryzon Genomics, S.A. Oxidase inhibitors and their use
GB0821913D0 (en) 2008-12-02 2009-01-07 Price & Co Antibacterial compounds
KR101784830B1 (en) 2008-12-03 2017-10-16 프레시디오 파마슈티칼스, 인코포레이티드 Inhibitors of hcv ns5a
WO2010065668A1 (en) * 2008-12-03 2010-06-10 Presidio Pharmaceuticals, Inc. Inhibitors of hcv ns5a
MX2011006332A (en) 2008-12-23 2011-06-27 Abbott Lab Anti-viral compounds.
CA2740195A1 (en) 2008-12-23 2010-07-01 Abbott Laboratories Anti-viral compounds
US8993808B2 (en) 2009-01-21 2015-03-31 Oryzon Genomics, S.A. Phenylcyclopropylamine derivatives and their medical use
US8394968B2 (en) 2009-02-17 2013-03-12 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
TWI438200B (en) * 2009-02-17 2014-05-21 必治妥美雅史谷比公司 Hepatitis c virus inhibitors
US8796466B2 (en) 2009-03-30 2014-08-05 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
TW201038559A (en) 2009-04-09 2010-11-01 Bristol Myers Squibb Co Hepatitis C virus inhibitors
US8143414B2 (en) 2009-04-13 2012-03-27 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
WO2010120935A1 (en) 2009-04-15 2010-10-21 Abbott Laboratories Anti-viral compounds
MX363732B (en) 2009-05-13 2019-04-01 Gilead Pharmasset Llc Star Antiviral compounds.
US8138215B2 (en) 2009-05-29 2012-03-20 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8211928B2 (en) 2009-05-29 2012-07-03 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8980920B2 (en) * 2009-05-29 2015-03-17 Merck Sharp & Dohme Corp. Antiviral compounds of three linked aryl moieties to treat diseases such as hepatitis C
CA2762885A1 (en) * 2009-05-29 2010-12-02 Schering Corporation Antiviral compounds composed of three aligned aryl moieties to treat diseases such as hepatitis c
US8937150B2 (en) 2009-06-11 2015-01-20 Abbvie Inc. Anti-viral compounds
US8716454B2 (en) 2009-06-11 2014-05-06 Abbvie Inc. Solid compositions
CN102333772B (en) 2009-06-11 2013-12-11 雅培制药有限公司 Anti-viral compounds
US9394279B2 (en) 2009-06-11 2016-07-19 Abbvie Inc. Anti-viral compounds
JP2012533569A (en) 2009-07-16 2012-12-27 ヴァーテックス ファーマシューティカルズ、 インコーポレイテッド Benzimidazole analogues for treating or preventing flavivirus infections
EP2473056A4 (en) 2009-09-04 2013-02-13 Glaxosmithkline Llc Chemical compounds
KR101736218B1 (en) 2009-09-25 2017-05-16 오리존 지노믹스 에스.에이. Lysine Specific Demethylase-1 INHIBITORS THEIR USE
EP2486002B1 (en) 2009-10-09 2019-03-27 Oryzon Genomics, S.A. Substituted heteroaryl- and aryl- cyclopropylamine acetamides and their use
UA108211C2 (en) * 2009-11-04 2015-04-10 Янссен Рід Айрленд Benzimidazole imidazole derivatives
US20110269956A1 (en) 2009-11-11 2011-11-03 Bristol-Myers Squibb Company Hepatitis C Virus Inhibitors
US20110274648A1 (en) * 2009-11-11 2011-11-10 Bristol-Myers Squibb Company Hepatitis C Virus Inhibitors
US20110281910A1 (en) 2009-11-12 2011-11-17 Bristol-Myers Squibb Company Hepatitis C Virus Inhibitors
US8377980B2 (en) 2009-12-16 2013-02-19 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
AU2010330862B2 (en) 2009-12-18 2015-06-25 Idenix Pharmaceuticals, Inc. 5,5-fused arylene or heteroarylene hepatitis C virus inhibitors
US20110152246A1 (en) * 2009-12-18 2011-06-23 Intermune, Inc. Novel inhibitors of hepatitis c virus replication
US8362020B2 (en) 2009-12-30 2013-01-29 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US9186337B2 (en) 2010-02-24 2015-11-17 Oryzon Genomics S.A. Lysine demethylase inhibitors for diseases and disorders associated with Hepadnaviridae
WO2011106105A2 (en) 2010-02-24 2011-09-01 Oryzon Genomics, S.A. Inhibitors for antiviral use
CN102858157A (en) * 2010-03-04 2013-01-02 埃南塔制药公司 Combination pharmaceutical agents as inhibitors of hcv replication
WO2011119853A1 (en) * 2010-03-24 2011-09-29 Vertex Pharmaceuticals Incorporated Analogues for the treatment or prevention of flavivirus infections
TW201139438A (en) * 2010-03-24 2011-11-16 Vertex Pharma Analogues for the treatment or prevention of flavivirus infections
TW201141857A (en) * 2010-03-24 2011-12-01 Vertex Pharma Analogues for the treatment or prevention of flavivirus infections
US8722743B2 (en) 2010-04-19 2014-05-13 Oryzon Genomics S.A. Lysine specific demethylase-1 inhibitors and their use
EP2575866A4 (en) * 2010-05-24 2013-10-16 Presidio Pharmaceuticals Inc Inhibitors of hcv ns5a
CA2800530A1 (en) * 2010-05-28 2011-12-01 Presidio Pharmaceuticals, Inc. Inhibitors of hcv ns5a
PL2575968T3 (en) 2010-06-01 2016-07-29 Summit Oxford Ltd Compounds for the treatment of clostridium difficile associated disease
NZ605440A (en) 2010-06-10 2014-05-30 Abbvie Bahamas Ltd Solid compositions comprising an hcv inhibitor
EP3012258B1 (en) 2010-06-24 2018-09-19 Gilead Sciences, Inc. Pharmaceutical composition comprising a pyrazolo[1,5-a]pyrimidine derivative as an antiviral agent
WO2012006060A1 (en) 2010-06-28 2012-01-12 Vertex Pharmaceuticals Incorporated Compounds and methods for the treatment or prevention of flavivirus infections
AR081691A1 (en) 2010-06-28 2012-10-10 Vertex Pharma THIOPHEN DERIVATIVES, METHODS FOR PREPARATION AND USE IN THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS
EP3375775A1 (en) 2010-07-29 2018-09-19 Oryzon Genomics, S.A. Arylcyclopropylamine based demethylase inhibitors of lsd1 and their medical use
WO2012013727A1 (en) 2010-07-29 2012-02-02 Oryzon Genomics S.A. Cyclopropylamine derivatives useful as lsd1 inhibitors
GB2482501A (en) * 2010-08-04 2012-02-08 Summit Corp Plc Novel compounds for use in the treatment of Clostridium Difficile and associated diseases
CN103153978A (en) 2010-08-17 2013-06-12 沃泰克斯药物股份有限公司 Compounds and methods for the treatment or prevention of flaviviridae viral infections
US20130196990A1 (en) 2010-10-06 2013-08-01 Junya Qu Benzimidazole Derivatives As PI3 Kinase Inhibitors
WO2012045883A1 (en) 2010-10-08 2012-04-12 Oryzon Genomics S.A. Cyclopropylamine inhibitors of oxidases
AU2014203655B2 (en) * 2010-10-13 2016-07-07 Abbvie Ireland Unlimited Company Anti-viral compounds
SG190785A1 (en) * 2010-11-17 2013-07-31 Gilead Sciences Inc Antiviral compounds
WO2012072713A2 (en) * 2010-11-30 2012-06-07 Oryzon Genomics, S.A. Lysine demethylase inhibitors for diseases and disorders associated with flaviviridae
WO2012083170A1 (en) * 2010-12-16 2012-06-21 Abbott Laboratories Anti-viral compounds
WO2012087976A2 (en) * 2010-12-21 2012-06-28 Intermune, Inc. Novel inhibitors of hepatitis c virus replication
US8552047B2 (en) 2011-02-07 2013-10-08 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
EP2712315B1 (en) 2011-02-08 2021-11-24 Oryzon Genomics, S.A. Lysine demethylase inhibitors for myeloproliferative disorders
GB201106817D0 (en) 2011-04-21 2011-06-01 Astex Therapeutics Ltd New compound
US9546160B2 (en) 2011-05-12 2017-01-17 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US10201584B1 (en) 2011-05-17 2019-02-12 Abbvie Inc. Compositions and methods for treating HCV
JP5669984B2 (en) 2011-05-18 2015-02-18 エナンタ ファーマシューティカルズ インコーポレイテッド Process for producing 5-azaspiro [2.4] heptane-6-carboxylic acid and derivatives thereof
KR20140040801A (en) 2011-07-15 2014-04-03 시오노기세야쿠 가부시키가이샤 Azabenzimidazole derivative having ampk-activating activity
AR087344A1 (en) 2011-07-26 2014-03-19 Vertex Pharma ACID POLYMORPHIC FORMS 5- (3,3-DIMETIL-BUT-1-INIL) -3 - [(TRANS-4-HIDROXI-CICLOHEXIL) - (TRANS-4-METHYL-CYCLHEXANCARBONYL) -AMINO] -TIOFEN-2- CARBOXILICO AND ITS USE IN THE TREATMENT OF HEPATITIS C
WO2013016499A1 (en) 2011-07-26 2013-01-31 Vertex Pharmaceuticals Incorporated Methods for preparation of thiophene compounds
WO2013021344A1 (en) 2011-08-08 2013-02-14 Lupin Limited Imidazole derivatives as antiviral agents
EP2709613B2 (en) 2011-09-16 2020-08-12 Gilead Pharmasset LLC Methods for treating hcv
WO2013057322A1 (en) 2011-10-20 2013-04-25 Oryzon Genomics, S.A. (hetero)aryl cyclopropylamine compounds as lsd1 inhibitors
AU2012324803B9 (en) 2011-10-20 2017-08-24 Oryzon Genomics, S.A. (hetero)aryl cyclopropylamine compounds as LSD1 inhibitors
SI2635588T1 (en) 2011-11-16 2015-10-30 Gilead Pharmasset Llc Condensed imidazolylimidazoles as antiviral compounds
AU2012358805B2 (en) 2011-12-22 2017-07-20 Gilead Sciences, Inc. Pyrazolo[1,5-a]pyrimidines as antiviral agents
RU2621734C1 (en) 2011-12-28 2017-06-07 Янссен Сайенсиз Айрлэнд Юси Heterobicyclic derivatives as hcv inhibitors
US9034832B2 (en) 2011-12-29 2015-05-19 Abbvie Inc. Solid compositions
US9326973B2 (en) 2012-01-13 2016-05-03 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
PE20142462A1 (en) * 2012-02-13 2015-02-01 Presidio Pharmaceuticals Inc SOLID FORMS INCLUDING HCV NS5A INHIBITORS, THEIR COMPOSITIONS AND THEIR USES
WO2013142157A1 (en) 2012-03-22 2013-09-26 Alios Biopharma, Inc. Pharmaceutical combinations comprising a thionucleotide analog
US8980878B2 (en) 2012-04-17 2015-03-17 Gilead Sciences, Inc. Compounds and methods for antiviral treatment
US20130309196A1 (en) 2012-05-16 2013-11-21 Gilead Sciences, Inc. Antiviral compounds
TWI610916B (en) * 2012-08-03 2018-01-11 廣東東陽光藥業有限公司 Bridged ring compounds as hepatitis c virus (hcv) inhibitors and pharmaceuticals applications thereof
BR112015014579A2 (en) 2012-12-19 2017-07-11 Basf Se compounds of formula i, use of a compound of formula i, method for combating harmful fungi and seeds.
EP2746274A1 (en) 2012-12-19 2014-06-25 Basf Se Substituted [1,2,4]triazole compounds
BR112015014303A2 (en) 2012-12-19 2017-07-11 Basf Se compounds of formula I, process for the preparation of compounds of formula I, agrochemical compositions, use of a compound of formula I, method for combating fungi, seed and intermediate compounds xx3
EP2746277A1 (en) 2012-12-19 2014-06-25 Basf Se Fungicidal imidazolyl and triazolyl compounds
EP2935236B1 (en) 2012-12-19 2017-11-29 Basf Se Substituted [1,2,4]triazole compounds and their use as fungicides
EP2746278A1 (en) 2012-12-19 2014-06-25 Basf Se Substituted [1,2,4]triazole and imidazole compounds
EP2746263A1 (en) 2012-12-19 2014-06-25 Basf Se Alpha-substituted triazoles and imidazoles
EP2745691A1 (en) 2012-12-19 2014-06-25 Basf Se Substituted imidazole compounds and their use as fungicides
EP2746262A1 (en) 2012-12-19 2014-06-25 Basf Se Substituted [1,2,4]triazole and imidazole compounds for combating phytopathogenic fungi
US20140212491A1 (en) 2013-01-31 2014-07-31 Gilead Pharmasset Llc Combination formulation of two antiviral compounds
WO2014134251A1 (en) 2013-02-28 2014-09-04 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions
US11484534B2 (en) 2013-03-14 2022-11-01 Abbvie Inc. Methods for treating HCV
US9717712B2 (en) 2013-07-02 2017-08-01 Bristol-Myers Squibb Company Combinations comprising tricyclohexadecahexaene derivatives for use in the treatment of hepatitis C virus
US20150023913A1 (en) 2013-07-02 2015-01-22 Bristol-Myers Squibb Company Hepatitis C Virus Inhibitors
CN105530933B (en) 2013-07-17 2018-12-11 百时美施贵宝公司 For treating the combination product comprising biphenyl derivatives of HCV
EP3038601B1 (en) 2013-08-27 2020-04-08 Gilead Pharmasset LLC Combination formulation of two antiviral compounds
KR101561964B1 (en) 2013-11-15 2015-10-20 한국과학기술연구원 Oxazolidinone derivatives and composition for preventing or treating Hepatitis C containing the same
LT3083616T (en) 2013-12-20 2021-09-10 Astex Therapeutics Limited Bicyclic heterocycle compounds and their uses in therapy
EP3089757A1 (en) 2014-01-03 2016-11-09 AbbVie Inc. Solid antiviral dosage forms
TWI721947B (en) 2014-06-11 2021-03-21 美商基利法瑪席特有限責任公司 Solid forms of an antiviral compound
WO2016004413A2 (en) * 2014-07-03 2016-01-07 Board Of Regents, University Of Texas System Gls1 inhibitors for treating disease
CA2953989C (en) 2014-07-03 2023-10-10 Board Of Regents, The University Of Texas System Gls1 inhibitors for treating disease
WO2016089814A1 (en) 2014-12-02 2016-06-09 Concert Pharmaceuticals, Inc. Deuterated analogues of daclatasvir
EP3316887B1 (en) 2015-06-30 2020-04-08 Board of Regents, The University of Texas System Gls1 inhibitors for treating disease
WO2017023631A1 (en) 2015-08-06 2017-02-09 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
SG11201804664XA (en) 2015-12-22 2018-07-30 Univ Texas Salt forms and polymorphs of (r)-1-(4-(6-(2-(4-(3,3-difluorocyclobutoxy)-6-methylpyridin-2-yl) acetamido) pyridazin-3-yl)-2-fluorobutyl)-n-methyl-1h-1,2,3-triazole-4-carboxamide
CN108794454B (en) * 2017-04-27 2023-08-15 广东东阳光药业股份有限公司 Preparation method of imidazole ring compound
JP7361687B2 (en) 2017-10-18 2023-10-16 ボード オブ レジェンツ,ザ ユニバーシティ オブ テキサス システム Glutaminase inhibitor therapy
IL300572A (en) 2018-02-13 2023-04-01 Gilead Sciences Inc Pd-1/pd-l1 inhibitors
WO2019204609A1 (en) 2018-04-19 2019-10-24 Gilead Sciences, Inc. Pd-1/pd-l1 inhibitors
KR20230159715A (en) 2018-07-13 2023-11-21 길리애드 사이언시즈, 인코포레이티드 Pd-1/pd-l1 inhibitors
EP3870566A1 (en) 2018-10-24 2021-09-01 Gilead Sciences, Inc. Pd-1/pd-l1 inhibitors
CN114835691B (en) * 2021-02-01 2024-08-20 江苏天士力帝益药业有限公司 Benzimidazole derivative and application thereof
CN117460734A (en) 2021-05-21 2024-01-26 吉利德科学公司 Pentacyclic derivatives as Zika virus inhibitors

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2502856C (en) 1992-12-29 2009-01-20 Abbott Laboratories Intermediates for retroviral protease inhibiting compounds
US5497763A (en) 1993-05-21 1996-03-12 Aradigm Corporation Disposable package for intrapulmonary delivery of aerosolized formulations
US5508269A (en) 1994-10-19 1996-04-16 Pathogenesis Corporation Aminoglycoside formulation for aerosolization
US6083922A (en) 1996-04-02 2000-07-04 Pathogenesis, Corp. Method and a tobramycin aerosol formulation for treatment prevention and containment of tuberculosis
US5767068A (en) 1997-02-13 1998-06-16 Pathogenesis Corporation Pure biologically active colistin, its components and a colistin formulation for treatment of pulmonary infections
IL141438A0 (en) 2000-02-23 2002-03-10 Pfizer Prod Inc Method of increasing the bioavailability and tissue penetration of azithromycin
US7105526B2 (en) 2002-06-28 2006-09-12 Banyu Pharmaceuticals Co., Ltd. Benzimidazole derivatives
WO2004014852A2 (en) 2002-08-12 2004-02-19 Bristol-Myers Squibb Company Iminothiazolidinones as inhibitors of hcv replication
DE10237722A1 (en) * 2002-08-17 2004-08-19 Aventis Pharma Deutschland Gmbh Indole or benzimidazole derivatives for the modulation of IKappaB kinase
MXPA05005773A (en) 2002-12-16 2005-08-16 Boehringer Ingelheim Int Use of a combination containing a non-nucleoside reverse transcriptase inhibitor (nnrti) with an inhibitor of cytochrome p450, such as protease inhibitors.
SI2161273T1 (en) * 2003-12-22 2015-10-30 K.U.Leuven Research & Development Imidazo(4,5-c)pyridine compounds and methods of antiviral treatment
GB0501964D0 (en) 2005-01-31 2005-03-09 Arrow Therapeutics Ltd Chemical compounds
US8143288B2 (en) * 2005-06-06 2012-03-27 Bristol-Myers Squibb Company Inhibitors of HCV replication
DK1940786T3 (en) 2005-09-16 2010-11-08 Arrow Therapeutics Ltd Biphenyl derivatives and their use in the treatment of hepatitis C
WO2007070556A2 (en) 2005-12-12 2007-06-21 Genelabs Technologies, Inc. N-(6-membered aromatic ring)-amido anti-viral compounds
US7595398B2 (en) 2005-12-12 2009-09-29 Smithkline Beecham Corporation N-(5-membered aromatic ring)-amido anti-viral compounds
WO2007082554A1 (en) 2006-01-23 2007-07-26 Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa Modulators of hcv replication
GB0608899D0 (en) * 2006-05-05 2006-06-14 Leuven K U Res & Dev Novel viral replication inhibitors
WO2008021851A2 (en) 2006-08-09 2008-02-21 Smithkline Beecham Corporation Novel compounds as antagonists or inverse agonists for opioid receptors
US7759495B2 (en) 2006-08-11 2010-07-20 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7659270B2 (en) 2006-08-11 2010-02-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8329159B2 (en) * 2006-08-11 2012-12-11 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
EP2076264A2 (en) 2006-10-13 2009-07-08 XTL Biopharmaceuticals LTD Compounds and methods for treatment of hcv
US20100055071A1 (en) 2006-11-21 2010-03-04 Martin Robert Leivers Anti-Viral Compounds
WO2008064218A2 (en) 2006-11-21 2008-05-29 Smithkline Beecham Corporation Amido anti-viral compounds
US7741347B2 (en) 2007-05-17 2010-06-22 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
TW200906826A (en) 2007-06-12 2009-02-16 Genelabs Tech Inc Anti-viral inhibitors and methods of use
WO2009003009A1 (en) * 2007-06-26 2008-12-31 Enanta Pharmaceuticals, Inc. Substituted pyrrolidine as anti-infectives
US7728027B2 (en) 2007-08-08 2010-06-01 Bristol-Myers Squibb Company Process for synthesizing compounds useful for treating hepatitis C
US8629171B2 (en) 2007-08-08 2014-01-14 Bristol-Myers Squibb Company Crystalline form of methyl ((1S)-1-((25)-2-(5-(4'-(2-((25)-1((2S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)-2-methylpropyl)carbamate dihydrochloride salt
WO2009034390A1 (en) 2007-09-14 2009-03-19 Arrow Therapeutics Limited Heterocyclic derivatives and their use in treating hepatitis c
EP2242751B1 (en) 2008-02-12 2015-07-15 Bristol-Myers Squibb Company Heterocyclic derivatives as hepatitis c virus inhibitors
MX2010008650A (en) 2008-02-12 2010-08-30 Bristol Myers Squibb Co Hepatitis c virus inhibitors.
ES2391600T3 (en) 2008-02-13 2012-11-28 Bristol-Myers Squibb Company Imidazoli biphenyl imidazoles as hepatitis C virus inhibitors
US7704992B2 (en) 2008-02-13 2010-04-27 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8147818B2 (en) 2008-02-13 2012-04-03 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
KR101784830B1 (en) * 2008-12-03 2017-10-16 프레시디오 파마슈티칼스, 인코포레이티드 Inhibitors of hcv ns5a
WO2010065668A1 (en) * 2008-12-03 2010-06-10 Presidio Pharmaceuticals, Inc. Inhibitors of hcv ns5a
TWI438200B (en) * 2009-02-17 2014-05-21 必治妥美雅史谷比公司 Hepatitis c virus inhibitors
UA108211C2 (en) * 2009-11-04 2015-04-10 Янссен Рід Айрленд Benzimidazole imidazole derivatives

Also Published As

Publication number Publication date
ZA201106629B (en) 2015-06-24
EP2400846A1 (en) 2012-01-04
CN102427731B (en) 2015-05-13
JP5628841B2 (en) 2014-11-19
JP2014205694A (en) 2014-10-30
CN102427731A (en) 2012-04-25
RU2011135605A (en) 2013-04-10
KR20110120976A (en) 2011-11-04
IL214775A (en) 2014-09-30
BRPI1007836A2 (en) 2015-09-01
KR101411889B1 (en) 2014-06-27
NZ595280A (en) 2013-11-29
MX2011008982A (en) 2011-09-15
WO2010099527A1 (en) 2010-09-02
IL214775A0 (en) 2011-11-30
KR20130130875A (en) 2013-12-02
MY160130A (en) 2017-02-28
JP2012519185A (en) 2012-08-23
CA2753382A1 (en) 2010-09-02
SG174146A1 (en) 2011-10-28
AU2010217797A1 (en) 2011-10-06
CA2753382C (en) 2014-12-23
RU2544010C2 (en) 2015-03-10
AU2010217797B2 (en) 2014-02-20
EP2400846A4 (en) 2012-10-03
EP2400846B1 (en) 2016-10-05
ES2606717T3 (en) 2017-03-27

Similar Documents

Publication Publication Date Title
HUS1500019I1 (en) Hepatitis C virus inhibitors
IL219516A0 (en) Hepatitis c virus inhibitors
HK1163067A1 (en) Hepatitis c virus inhibitors
IL219517A0 (en) Hepatitis c virus inhibitors
ZA201107095B (en) Hepatitis c virus inhibitors
ZA201106795B (en) Hepatitis c virus inhibitors
ZA201106669B (en) Hepatitis c virus inhibitors
ZA201106629B (en) Hepatitis c virus inhibitors
EP2512480A4 (en) Hepatitis c virus inhibitors
EP2475254A4 (en) Hepatitis c virus inhibitors
EP2475256A4 (en) Hepatitis c virus inhibitors
HK1143812A1 (en) Hepatitis c virus inhibitors
IL207470A0 (en) Hepatitis c virus inhibitors
IL221033A0 (en) Hepatitis c virus inhibitors
EP2575819A4 (en) Hepatitis c virus inhibitors
IL224298A (en) Hepatitis c virus inhibitors
EP2603080A4 (en) Hepatitis c virus inhibitors
EP2429568A4 (en) Macrocyclic compounds as hepatitis c virus inhibitors
EP2504343A4 (en) Hepatitis c inhibitor compounds
GB0912950D0 (en) Virus
GB0901056D0 (en) Virus
SI2368890T1 (en) Hepatitis C virus inhibitors
TH105924B (en) Hepatitis C virus inhibitors