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SE8903219D0 - Process for the manufacture of budesonide - Google Patents

Process for the manufacture of budesonide

Info

Publication number
SE8903219D0
SE8903219D0 SE8903219A SE8903219A SE8903219D0 SE 8903219 D0 SE8903219 D0 SE 8903219D0 SE 8903219 A SE8903219 A SE 8903219A SE 8903219 A SE8903219 A SE 8903219A SE 8903219 D0 SE8903219 D0 SE 8903219D0
Authority
SE
Sweden
Prior art keywords
alpha
manufacture
budesonide
diene
beta
Prior art date
Application number
SE8903219A
Other languages
English (en)
Inventor
R G Hofstraat
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Priority to SE8903219A priority Critical patent/SE8903219D0/sv
Publication of SE8903219D0 publication Critical patent/SE8903219D0/sv
Priority to ES90915222T priority patent/ES2079491T3/es
Priority to HU9201064A priority patent/HU212576B/hu
Priority to PCT/SE1990/000619 priority patent/WO1991004984A1/en
Priority to DE69023664T priority patent/DE69023664T2/de
Priority to KR1019920700728A priority patent/KR0160527B1/ko
Priority to CA002065861A priority patent/CA2065861C/en
Priority to EP90915222A priority patent/EP0494942B1/en
Priority to AU65309/90A priority patent/AU632864B2/en
Priority to RO92-200446A priority patent/RO110947B1/ro
Priority to BR909007700A priority patent/BR9007700A/pt
Priority to DK90915222.5T priority patent/DK0494942T3/da
Priority to UA94010159A priority patent/UA26860C2/uk
Priority to SU905011922A priority patent/RU2048472C1/ru
Priority to AT90915222T priority patent/ATE130310T1/de
Priority to JP2514161A priority patent/JP2965352B2/ja
Priority to SG1996008769A priority patent/SG43344A1/en
Priority to NO921233A priority patent/NO178827C/no
Priority to BG96166A priority patent/BG61608B1/bg
Priority to FI921426A priority patent/FI103204B1/sv
Priority to LVP-93-858A priority patent/LV10283B/xx
Priority to LTIP1729A priority patent/LT3697B/lt
Priority to US08/357,773 priority patent/US5556964A/en
Priority to HK52097A priority patent/HK52097A/xx
Priority to CY9802084A priority patent/CY2084B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0092—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by an OH group free esterified or etherified

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Paper (AREA)
  • Load-Bearing And Curtain Walls (AREA)
SE8903219A 1989-10-02 1989-10-02 Process for the manufacture of budesonide SE8903219D0 (sv)

Priority Applications (25)

Application Number Priority Date Filing Date Title
SE8903219A SE8903219D0 (sv) 1989-10-02 1989-10-02 Process for the manufacture of budesonide
JP2514161A JP2965352B2 (ja) 1989-10-02 1990-09-27 ブデソニドの製造方法
BR909007700A BR9007700A (pt) 1989-10-02 1990-09-27 Processo para a fabricacao de budesonida
UA94010159A UA26860C2 (uk) 1989-10-02 1990-09-27 Спосіб одержаhhя (22r,s)-16 альфа,17 альфа-бутилідеhдіокси-11 бета, 21-дигідроксипрегhа-1,4-дієh-3,20-діоhу
PCT/SE1990/000619 WO1991004984A1 (en) 1989-10-02 1990-09-27 Process for the manufacture of budesonide
DE69023664T DE69023664T2 (de) 1989-10-02 1990-09-27 Verfahren zur herstellung von budesonid.
KR1019920700728A KR0160527B1 (ko) 1989-10-02 1990-09-27 부데소나이드의 제조방법
CA002065861A CA2065861C (en) 1989-10-02 1990-09-27 Process for the manufacture of budesonide
EP90915222A EP0494942B1 (en) 1989-10-02 1990-09-27 Process for the manufacture of budesonide
AU65309/90A AU632864B2 (en) 1989-10-02 1990-09-27 Process for the manufacture of budesonide
RO92-200446A RO110947B1 (ro) 1989-10-02 1990-09-27 Procedeu de obtinere a (22-r,s)-16alfa,17alfa-butilidendioxi-11 beta-21-dihidroxi-1,4-pregnadiena-3,20-dionei
ES90915222T ES2079491T3 (es) 1989-10-02 1990-09-27 Procedimiento de fabricacion de budesonida.
DK90915222.5T DK0494942T3 (da) 1989-10-02 1990-09-27 Fremgangsmåde til fremstilling af budesonid
HU9201064A HU212576B (en) 1989-10-02 1990-09-27 New process for producing budes onide
SU905011922A RU2048472C1 (ru) 1989-10-02 1990-09-27 СПОСОБ ПОЛУЧЕНИЯ (22R,S)- 16α, 17α -БУTИЛИДEHДИOKCИ- 11β, 21 -ДИГИДPOKCИПPEГHA-1,4-ДИEH-3,20-ДИOHA
AT90915222T ATE130310T1 (de) 1989-10-02 1990-09-27 Verfahren zur herstellung von budesonid.
SG1996008769A SG43344A1 (en) 1989-10-02 1990-11-27 Process for the manufacture of budesonide
NO921233A NO178827C (no) 1989-10-02 1992-03-30 Fremgangsmåte for fremstilling av budesonid
BG96166A BG61608B1 (bg) 1989-10-02 1992-04-01 Метод за получаване на будезонид
FI921426A FI103204B1 (sv) 1989-10-02 1992-04-01 Förfarande för framställning av budesonid
LVP-93-858A LV10283B (en) 1989-10-02 1993-06-30 Process for the manufacture of budesonide
LTIP1729A LT3697B (en) 1989-10-02 1993-12-30 Process for the manufacture of budesonide
US08/357,773 US5556964A (en) 1989-10-02 1994-12-16 Process for the manufacture of budesonide
HK52097A HK52097A (en) 1989-10-02 1997-04-24 Process for the manufacture of budesonide
CY9802084A CY2084B1 (en) 1989-10-02 1998-10-16 Process for the manufacture of budesonide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8903219A SE8903219D0 (sv) 1989-10-02 1989-10-02 Process for the manufacture of budesonide

Publications (1)

Publication Number Publication Date
SE8903219D0 true SE8903219D0 (sv) 1989-10-02

Family

ID=20377019

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8903219A SE8903219D0 (sv) 1989-10-02 1989-10-02 Process for the manufacture of budesonide

Country Status (25)

Country Link
US (1) US5556964A (sv)
EP (1) EP0494942B1 (sv)
JP (1) JP2965352B2 (sv)
KR (1) KR0160527B1 (sv)
AT (1) ATE130310T1 (sv)
AU (1) AU632864B2 (sv)
BG (1) BG61608B1 (sv)
BR (1) BR9007700A (sv)
CA (1) CA2065861C (sv)
CY (1) CY2084B1 (sv)
DE (1) DE69023664T2 (sv)
DK (1) DK0494942T3 (sv)
ES (1) ES2079491T3 (sv)
FI (1) FI103204B1 (sv)
HK (1) HK52097A (sv)
HU (1) HU212576B (sv)
LT (1) LT3697B (sv)
LV (1) LV10283B (sv)
NO (1) NO178827C (sv)
RO (1) RO110947B1 (sv)
RU (1) RU2048472C1 (sv)
SE (1) SE8903219D0 (sv)
SG (1) SG43344A1 (sv)
UA (1) UA26860C2 (sv)
WO (1) WO1991004984A1 (sv)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6028190A (en) 1994-02-01 2000-02-22 The Regents Of The University Of California Probes labeled with energy transfer coupled dyes
US6166024A (en) 1995-03-30 2000-12-26 Mayo Foundation For Medical Education And Research Use of topical azathioprine and thioguanine to treat colorectal adenomas
IT1291288B1 (it) 1997-04-30 1999-01-07 Farmabios Srl Processo per la preparazione di 16,17 acetali di derivati pregnanici con controllo della distribuzione epimerica al c-22.
SE9704186D0 (sv) * 1997-11-14 1997-11-14 Astra Ab New composition of matter
US6266556B1 (en) 1998-04-27 2001-07-24 Beth Israel Deaconess Medical Center, Inc. Method and apparatus for recording an electroencephalogram during transcranial magnetic stimulation
FR2782823B1 (fr) 1998-09-01 2000-11-17 Neopost Ind Procede d'impression thermique
US6234167B1 (en) 1998-10-14 2001-05-22 Chrysalis Technologies, Incorporated Aerosol generator and methods of making and using an aerosol generator
US6681998B2 (en) 2000-12-22 2004-01-27 Chrysalis Technologies Incorporated Aerosol generator having inductive heater and method of use thereof
US6701921B2 (en) 2000-12-22 2004-03-09 Chrysalis Technologies Incorporated Aerosol generator having heater in multilayered composite and method of use thereof
US6491233B2 (en) 2000-12-22 2002-12-10 Chrysalis Technologies Incorporated Vapor driven aerosol generator and method of use thereof
US6501052B2 (en) 2000-12-22 2002-12-31 Chrysalis Technologies Incorporated Aerosol generator having multiple heating zones and methods of use thereof
US6799572B2 (en) 2000-12-22 2004-10-05 Chrysalis Technologies Incorporated Disposable aerosol generator system and methods for administering the aerosol
US20030055026A1 (en) * 2001-04-17 2003-03-20 Dey L.P. Formoterol/steroid bronchodilating compositions and methods of use thereof
US6568390B2 (en) 2001-09-21 2003-05-27 Chrysalis Technologies Incorporated Dual capillary fluid vaporizing device
US6640050B2 (en) 2001-09-21 2003-10-28 Chrysalis Technologies Incorporated Fluid vaporizing device having controlled temperature profile heater/capillary tube
US6804458B2 (en) 2001-12-06 2004-10-12 Chrysalis Technologies Incorporated Aerosol generator having heater arranged to vaporize fluid in fluid passage between bonded layers of laminate
US6681769B2 (en) 2001-12-06 2004-01-27 Crysalis Technologies Incorporated Aerosol generator having a multiple path heater arrangement and method of use thereof
US6701922B2 (en) 2001-12-20 2004-03-09 Chrysalis Technologies Incorporated Mouthpiece entrainment airflow control for aerosol generators
TWI359675B (en) 2003-07-10 2012-03-11 Dey L P Bronchodilating β-agonist compositions
US20070020196A1 (en) * 2003-12-31 2007-01-25 Pipkin James D Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid prepared from a unit dose suspension
US20070020299A1 (en) 2003-12-31 2007-01-25 Pipkin James D Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid
US20070020298A1 (en) * 2003-12-31 2007-01-25 Pipkin James D Inhalant formulation containing sulfoalkyl ether gamma-cyclodextrin and corticosteroid
DE602004023765D1 (de) * 2004-03-12 2009-12-03 Trinity College Dublin Magnetoresistives medium
US20070197486A1 (en) * 2005-12-20 2007-08-23 Verus Pharmaceuticals, Inc. Methods and systems for the delivery of corticosteroids
US20070160542A1 (en) * 2005-12-20 2007-07-12 Verus Pharmaceuticals, Inc. Methods and systems for the delivery of corticosteroids having an enhanced pharmacokinetic profile
US20070185066A1 (en) * 2005-12-20 2007-08-09 Verus Pharmaceuticals, Inc. Systems and methods for the delivery of corticosteroids
US20070249572A1 (en) * 2005-12-20 2007-10-25 Verus Pharmaceuticals, Inc. Systems and methods for the delivery of corticosteroids
WO2007095341A2 (en) * 2006-02-15 2007-08-23 Tika Läkemedel Ab Sterilization of corticosteroids with reduced mass loss
CN102060906B (zh) * 2010-12-23 2013-01-16 鲁南贝特制药有限公司 一种r布地奈德的制备方法
US10233210B2 (en) * 2015-01-30 2019-03-19 Coral Drugs Pvt. Ltd. Process for preparation of glucocorticoid steroids

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3197469A (en) * 1958-08-06 1965-07-27 Pharmaceutical Res Products In 16, 17-acetals and ketals of 6-halo-16, 17-dihydroxy steroids of the pregnane seriesand intermediates therefor
US3077471A (en) * 1961-08-04 1963-02-12 Olin Mathieson Steroids of the 19-norpregnane series
SE378109B (sv) * 1972-05-19 1975-08-18 Bofors Ab
SE8008524L (sv) * 1980-12-04 1982-06-05 Draco Ab 4-pregnen-derivat, ett forfarande for deras framstellning, beredning och metod for behandling av inflammatoriska tillstand
IT1196142B (it) * 1984-06-11 1988-11-10 Sicor Spa Procedimento per la preparazione di 16,17-acetali di derivati pregnanici e nuovi composti ottenuti
SE8604059D0 (sv) * 1986-09-25 1986-09-25 Astra Pharma Prod A method of controlling the epimeric distribution in the preparation of 16,17-acetals of pregnane derivatives

Also Published As

Publication number Publication date
LTIP1729A (en) 1995-07-25
DE69023664D1 (de) 1995-12-21
CY2084B1 (en) 1998-10-16
AU6530990A (en) 1991-04-28
NO178827B (no) 1996-03-04
FI103204B (sv) 1999-05-14
BG61608B1 (bg) 1998-01-30
JP2965352B2 (ja) 1999-10-18
RO110947B1 (ro) 1996-05-30
NO178827C (no) 1996-06-12
LT3697B (en) 1996-02-26
EP0494942A1 (en) 1992-07-22
US5556964A (en) 1996-09-17
LV10283B (en) 1995-04-20
JPH05500669A (ja) 1993-02-12
CA2065861A1 (en) 1991-04-03
DK0494942T3 (da) 1996-03-11
ATE130310T1 (de) 1995-12-15
HU212576B (en) 1996-08-29
CA2065861C (en) 2001-06-05
HUT60281A (en) 1992-08-28
NO921233D0 (no) 1992-03-30
HU9201064D0 (en) 1992-06-29
FI921426A0 (fi) 1992-04-01
WO1991004984A1 (en) 1991-04-18
BR9007700A (pt) 1992-08-11
FI103204B1 (sv) 1999-05-14
NO921233L (no) 1992-03-30
FI921426A (fi) 1992-04-01
DE69023664T2 (de) 1996-05-02
HK52097A (en) 1997-05-02
AU632864B2 (en) 1993-01-14
SG43344A1 (en) 1997-10-17
BG96166A (bg) 1993-12-24
RU2048472C1 (ru) 1995-11-20
LV10283A (lv) 1994-10-20
UA26860C2 (uk) 1999-12-29
KR0160527B1 (ko) 1998-11-16
ES2079491T3 (es) 1996-01-16
EP0494942B1 (en) 1995-11-15

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