Nothing Special   »   [go: up one dir, main page]

SE8300370D0 - Antiaterosklerotiska substituerade karbamider och tiokarbamider - Google Patents

Antiaterosklerotiska substituerade karbamider och tiokarbamider

Info

Publication number
SE8300370D0
SE8300370D0 SE8300370A SE8300370A SE8300370D0 SE 8300370 D0 SE8300370 D0 SE 8300370D0 SE 8300370 A SE8300370 A SE 8300370A SE 8300370 A SE8300370 A SE 8300370A SE 8300370 D0 SE8300370 D0 SE 8300370D0
Authority
SE
Sweden
Prior art keywords
group
alkyl
phenyl
substituent
alkynyl
Prior art date
Application number
SE8300370A
Other languages
English (en)
Other versions
SE8300370L (sv
SE462653B (sv
Inventor
V G Devries
E E Largis
R B Conrow
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/342,693 external-priority patent/US4473579A/en
Priority claimed from US06/342,698 external-priority patent/US4387105A/en
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of SE8300370D0 publication Critical patent/SE8300370D0/sv
Publication of SE8300370L publication Critical patent/SE8300370L/sv
Publication of SE462653B publication Critical patent/SE462653B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
    • C07C273/1809—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety
    • C07C273/1818—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety from -N=C=O and XNR'R"
    • C07C273/1827—X being H
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Furan Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
SE8300370A 1982-01-26 1983-01-25 Substituerade karbamider, foerfarande foer framstaellning daerav, naemnda karbamider foer farmaceutisk anvaendning samt farmaceutisk komposition innehaallande naemnda karbamider SE462653B (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/342,693 US4473579A (en) 1982-01-26 1982-01-26 Antiatherosclerotic tetrasubstituted ureas and thioureas
US06/342,698 US4387105A (en) 1982-01-26 1982-01-26 Methods of treating atherosclerosis with dialkylureas and dialkylthioureas

Publications (3)

Publication Number Publication Date
SE8300370D0 true SE8300370D0 (sv) 1983-01-25
SE8300370L SE8300370L (sv) 1983-07-27
SE462653B SE462653B (sv) 1990-08-06

Family

ID=26993144

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8300370A SE462653B (sv) 1982-01-26 1983-01-25 Substituerade karbamider, foerfarande foer framstaellning daerav, naemnda karbamider foer farmaceutisk anvaendning samt farmaceutisk komposition innehaallande naemnda karbamider

Country Status (20)

Country Link
KR (1) KR890001808B1 (sv)
AT (1) AT391313B (sv)
AU (1) AU562699B2 (sv)
CH (1) CH654571A5 (sv)
DE (1) DE3247581A1 (sv)
DK (1) DK160869C (sv)
ES (2) ES519246A0 (sv)
FI (1) FI85013C (sv)
FR (1) FR2521134B1 (sv)
GB (1) GB2113684B (sv)
GR (1) GR77186B (sv)
HU (1) HU200746B (sv)
IE (1) IE54683B1 (sv)
IL (1) IL67417A (sv)
IT (1) IT1203647B (sv)
NL (1) NL8300269A (sv)
NO (1) NO158417C (sv)
PL (1) PL143836B1 (sv)
PT (1) PT76138A (sv)
SE (1) SE462653B (sv)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2138804A (en) * 1983-04-27 1984-10-31 Sumitomo Chemical Co Fungicidal N-phenylcarbamates
GB2149394B (en) * 1983-07-19 1986-09-24 American Cyanamid Co Ureas
US4818899A (en) * 1986-12-03 1989-04-04 Minnesota Mining And Manufacturing Company Second harmonic generation by carbamic acid derivatives
DE68911203T2 (de) * 1988-03-30 1994-04-14 Warner Lambert Co N-[[(2,6-disubstituierte)phenyl]N'- arylalkyl] Harnstoffe als antihypercholesterolemische und antiatherosclerotische Mittel.
US5116848A (en) * 1988-03-30 1992-05-26 Warner-Lambert Company N-(((2,6-disubstituted)phenyl)-n-diarylalkyl)ureas as antihyperlipidemic and antiatherosclerotic agents
WO1991011994A1 (en) * 1990-02-14 1991-08-22 Chugai Seiyaku Kabushiki Kaisha Inhibitor of denatured ldl formation
US5668136A (en) * 1990-09-25 1997-09-16 Eisai Co., Ltd. Trisubstituted benzene derivatives, composition and methods of treatment
HUT62558A (en) * 1991-07-01 1993-05-28 Sandoz Ag Process for producing n-phenylthiourea derivaties and pharmaceutical compositions comprising same
CA2115915A1 (en) * 1992-07-20 1994-02-03 Kenji Hayashi Benzene derivatives
AU8534198A (en) * 1997-08-05 1999-03-01 Novo Nordisk A/S Derivatives of 2,5- and 3,5-disubstituted anilines, their preparation and use
US6455566B1 (en) 1997-09-03 2002-09-24 Wyeth Substituted 1-aryl-3-heteroaryl-thioureas (or isothioureas) as antiatherosclerotic agents
TW415942B (en) * 1997-09-03 2000-12-21 American Home Prod Novel substituted 1-aryl-3-heteroaryl-thioureas and substituted 1-aryl-3-heteroaryl-isothioureas as antiatherosclerotic agents
JP2001501979A (ja) * 1998-01-21 2001-02-13 ザイモジェネティクス，インコーポレイティド カルシトニン擬態物としてのジアルキルウレア
WO2009009122A2 (en) * 2007-07-10 2009-01-15 Amgen Inc. Derivatives of urea and related diamines, methods for their manufacture, and uses therefor

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL92838C (sv) * 1949-12-06
US2688039A (en) * 1952-02-08 1954-08-31 Ciba Pharm Prod Inc Halogen-containing di-(substituted phenyl)-thioureas
US3326663A (en) * 1964-09-25 1967-06-20 Shell Oil Co Herbicidal phenylureas
US3335142A (en) * 1965-07-07 1967-08-08 American Cyanamid Co Process for the preparation of n, n'-disubstituted ureas
US3659012A (en) * 1969-05-26 1972-04-25 Lilly Co Eli Methods of treating helminth infections with thiourea derivatives
US3728386A (en) * 1970-07-27 1973-04-17 Exxon Research Engineering Co N-cycloalkylalkyl and n-cycloalkyl substituted phenyl ureas and halo acetamides
US3928437A (en) * 1970-09-02 1975-12-23 Ciba Geigy Corp Phenoxy-phenyl, phenylthiophenyl, phenylsulfonylphenyl and phenylaminophenyl diaminothioureas
US3856952A (en) * 1973-03-01 1974-12-24 Pennwalt Corp Synergistic antimicrobial compositions employing certain n-(phenyl-carbamyl)amino-benzene sulfonyl flourides
US3903130A (en) * 1974-05-03 1975-09-02 Stauffer Chemical Co 1-Trifluormethylphenyl-3-dicyanophenyl urea
DE2928485A1 (de) * 1979-07-14 1981-01-29 Bayer Ag Verwendung von harnstoffderivaten als arzneimittel bei der behandlung von fettstoffwechselstoerungen

Also Published As

Publication number Publication date
DK160869B (da) 1991-04-29
FI85013B (fi) 1991-11-15
AU1068183A (en) 1983-08-04
SE8300370L (sv) 1983-07-27
HU200746B (en) 1990-08-28
GR77186B (sv) 1984-09-11
ES531508A0 (es) 1985-07-01
NO158417B (no) 1988-05-30
SE462653B (sv) 1990-08-06
IT8347605A0 (it) 1983-01-25
GB2113684A (en) 1983-08-10
DK28683A (da) 1983-07-27
DK160869C (da) 1991-10-14
KR890001808B1 (ko) 1989-05-23
FR2521134A1 (fr) 1983-08-12
ATA23983A (de) 1990-03-15
ES8406422A1 (es) 1984-08-01
ES519246A0 (es) 1984-08-01
KR840002773A (ko) 1984-07-16
AU562699B2 (en) 1987-06-18
IL67417A (en) 1989-10-31
FI85013C (sv) 1992-02-25
NL8300269A (nl) 1983-08-16
PL240284A1 (en) 1985-01-02
NO158417C (no) 1988-09-07
IE54683B1 (en) 1990-01-03
NO830238L (no) 1983-07-27
CH654571A5 (de) 1986-02-28
AT391313B (de) 1990-09-25
GB8301863D0 (en) 1983-02-23
PT76138A (en) 1983-02-01
PL143836B1 (en) 1988-03-31
GB2113684B (en) 1985-12-18
FR2521134B1 (fr) 1987-01-09
IE830146L (en) 1983-07-26
DE3247581A1 (de) 1983-08-04
FI830247L (fi) 1983-07-27
DK28683D0 (da) 1983-01-25
ES8505943A1 (es) 1985-07-01
FI830247A0 (fi) 1983-01-25
IT1203647B (it) 1989-02-15

Similar Documents

Publication Publication Date Title
SE8300370D0 (sv) Antiaterosklerotiska substituerade karbamider och tiokarbamider
DK377389A (da) Heterocycliske n-arylsulfonamider, fremgangsmaade til deres fremstilling, midler indeholdende dem samt deres anvendelse som herbicider eller vaekstregulerende midler
DE58905006D1 (de) Harnstoffe.
ES555992A0 (es) Procedimiento para la obtencion de e-isomeros de derivados y peptidos de n&lt;-(2-ciano-2-alcoximino-acetil)-aminoacidos
ES484784A1 (es) Procedimiento para la obtencion de n-benzoil-n&#39;-terc.-alco- xicarbonilfenil-(tio)ureas sustituidas, de efecto insectici-da
ES8100800A1 (es) Procedimiento para la preparacion de derivados furanonicos
DE69903559D1 (de) Verwendung von neuen zelltod inducierenden mitteln im synergismus mit interferon
IL71361A0 (en) Urea derivatives,their preparation and their use as pesticides
DK157280A (da) N,n-disubstituerede ethylglycin (thiol)estere deres fremstilling samt deres anvendelse som fungicide midler
ES8500896A1 (es) Procedimiento para la obtencion de 1-fenil-3-benzoil-(tio)-ureas
BG40951A3 (en) Herbicide means
DE3686916D1 (de) Umsetzungsprodukte und kondensationsprodukte auf basis substituierter propylenharnstoffe, deren herstellung und verwendung.
IL78080A0 (en) Piperazinylmethyl-1,2,4-triazolylmethyl-carbinols,their preparation and their use as plant protecting agents
DK0733370T3 (da) Anvendelse af en genpromotorsekvens til behandling af rheumatiske sygdomme
GB2006759A (en) omega -Mercapto-propionamides and Pharmaceutical Preparations containing them
BG30315A3 (en) Antidot means for herbesides from the group of thiol carbamates and method of its application
ES508409A0 (es) Procedimiento para la obtencion de alofanatos n-sulfenilados.
ES2038164T3 (es) Una composicion herbicida.
WO1995016452A3 (en) Use of macrophage depleting agents for prolonging the survival of non-autologus hematopoietic cell transplants and animal model assay systems
ES8604008A1 (es) Procedimiento para la obtencion de productos herbicidas a base de derivados de dicloroquinolina
DE3161288D1 (en) N-(sulfenamido)-acylisocyanates, process for their preparation and their use as intermediates
DE3060203D1 (en) Herbicidal compositions containing 2,4-diamino-6-chloro-5-methylthio-pyrimidine and herbicidal urea derivatives and method of treatment of cultures with said compositions

Legal Events

Date Code Title Description
NAL Patent in force

Ref document number: 8300370-7

Format of ref document f/p: F

NUG Patent has lapsed

Ref document number: 8300370-7

Format of ref document f/p: F