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SE0301445D0 - Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof - Google Patents

Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof

Info

Publication number
SE0301445D0
SE0301445D0 SE0301445A SE0301445A SE0301445D0 SE 0301445 D0 SE0301445 D0 SE 0301445D0 SE 0301445 A SE0301445 A SE 0301445A SE 0301445 A SE0301445 A SE 0301445A SE 0301445 D0 SE0301445 D0 SE 0301445D0
Authority
SE
Sweden
Prior art keywords
sup
preparations
piperidine derivatives
diarylmethylidene piperidine
diarylmethylidene
Prior art date
Application number
SE0301445A
Other languages
English (en)
Swedish (sv)
Inventor
William Brown
Andrew Griffin
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Priority to SE0301445A priority Critical patent/SE0301445D0/xx
Publication of SE0301445D0 publication Critical patent/SE0301445D0/xx
Priority to UAA200510095A priority patent/UA81309C2/uk
Priority to US10/555,981 priority patent/US20070066655A1/en
Priority to NZ543232A priority patent/NZ543232A/en
Priority to JP2006530497A priority patent/JP2007500739A/ja
Priority to BRPI0410353-0A priority patent/BRPI0410353A/pt
Priority to EP04732646A priority patent/EP1626960A1/en
Priority to MXPA05012116A priority patent/MXPA05012116A/es
Priority to PCT/GB2004/002071 priority patent/WO2004101520A1/en
Priority to RU2005136537/04A priority patent/RU2005136537A/ru
Priority to CA002525858A priority patent/CA2525858A1/en
Priority to CNB2004800134157A priority patent/CN100415717C/zh
Priority to AU2004238616A priority patent/AU2004238616B2/en
Priority to KR1020057021775A priority patent/KR20060003104A/ko
Priority to ARP040101664A priority patent/AR044347A1/es
Priority to UY28318A priority patent/UY28318A1/es
Priority to TW093113589A priority patent/TW200510312A/zh
Priority to CO05114674A priority patent/CO5650250A2/es
Priority to ZA200509243A priority patent/ZA200509243B/en
Priority to IS8179A priority patent/IS8179A/is
Priority to NO20055997A priority patent/NO20055997L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Otolaryngology (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nutrition Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SE0301445A 2003-05-16 2003-05-16 Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof SE0301445D0 (sv)

Priority Applications (21)

Application Number Priority Date Filing Date Title
SE0301445A SE0301445D0 (sv) 2003-05-16 2003-05-16 Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
KR1020057021775A KR20060003104A (ko) 2003-05-16 2004-05-13 디아릴메틸리덴 피페리딘 유도체 및 델타 아편양제제수용체 아고니스트로서의 그의 용도
PCT/GB2004/002071 WO2004101520A1 (en) 2003-05-16 2004-05-13 Diarylmethylidene piperidine derivatives and their use as delta opiod receptor agonists
CA002525858A CA2525858A1 (en) 2003-05-16 2004-05-13 Diarylmethylidene piperidine derivatives and their use as delta opioid receptor agonists
NZ543232A NZ543232A (en) 2003-05-16 2004-05-13 Diarylmethylidene piperidine derivatives and their use as delta opioid receptor agonists
JP2006530497A JP2007500739A (ja) 2003-05-16 2004-05-13 ジアリールメチリデンピペリジン誘導体およびδオピオイド受容体アゴニストとしてのそれらの使用
BRPI0410353-0A BRPI0410353A (pt) 2003-05-16 2004-05-13 composto, uso de um composto, composição farmacêutica, métodos para as terapias da dor e da ansiedade em um animal de sangue quente, e, processo para preparar um composto
EP04732646A EP1626960A1 (en) 2003-05-16 2004-05-13 Diarylmethylidene piperidine derivatives and their use as delta opioid receptor agonists
MXPA05012116A MXPA05012116A (es) 2003-05-16 2004-05-13 Derivados de diarilmetilideno piperidina y su uso como agonistas del receptor opioide delta.
UAA200510095A UA81309C2 (en) 2003-05-16 2004-05-13 Diarylmethylidene piperidine derivatives and their use as delta opioid receptor agonists, metod for their preparation (variants), phameutical composition based thereon
RU2005136537/04A RU2005136537A (ru) 2003-05-16 2004-05-13 Производные диарилметилиденпиперидина и их применение в качестве агонистов дельтаопиоидных рецерторов
US10/555,981 US20070066655A1 (en) 2003-05-16 2004-05-13 Diarylmethylidene piperidine derivatives and their use as delta opiod receptor agonists
CNB2004800134157A CN100415717C (zh) 2003-05-16 2004-05-13 二芳基亚甲基哌啶衍生物及其作为δ阿片样受体激动剂的用途
AU2004238616A AU2004238616B2 (en) 2003-05-16 2004-05-13 Diarylmethylidene piperidine derivatives and their use as delta opioid receptor agonists
TW093113589A TW200510312A (en) 2003-05-16 2004-05-14 Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
ARP040101664A AR044347A1 (es) 2003-05-16 2004-05-14 Derivados de diarilmetiliden piperidina, sus preparaciones y sus usos como agonistas de receptores opiodes d
UY28318A UY28318A1 (es) 2003-05-16 2004-05-14 Derivados de diarilmetiliden piperidina, preparaciones de los mismos y sus usos
CO05114674A CO5650250A2 (es) 2003-05-16 2005-11-10 Derivados de diarilmetilden piperidina y su uso como agonistas del receptor opioide delta
ZA200509243A ZA200509243B (en) 2003-05-16 2005-11-15 Diarylmethylidene piperidine derivatives and their use as delta opiod receptor agonists
IS8179A IS8179A (is) 2003-05-16 2005-12-14 Díarýlmetýlídenpíparídínafleiður og notkun þeirrasem deltaópíóíðviðtakagerandefna
NO20055997A NO20055997L (no) 2003-05-16 2005-12-16 Diarylmetylidenpiperidinderivater og deres anvendelse som opiodreseptoragonister

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0301445A SE0301445D0 (sv) 2003-05-16 2003-05-16 Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof

Publications (1)

Publication Number Publication Date
SE0301445D0 true SE0301445D0 (sv) 2003-05-16

Family

ID=20291334

Family Applications (1)

Application Number Title Priority Date Filing Date
SE0301445A SE0301445D0 (sv) 2003-05-16 2003-05-16 Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof

Country Status (21)

Country Link
US (1) US20070066655A1 (es)
EP (1) EP1626960A1 (es)
JP (1) JP2007500739A (es)
KR (1) KR20060003104A (es)
CN (1) CN100415717C (es)
AR (1) AR044347A1 (es)
AU (1) AU2004238616B2 (es)
BR (1) BRPI0410353A (es)
CA (1) CA2525858A1 (es)
CO (1) CO5650250A2 (es)
IS (1) IS8179A (es)
MX (1) MXPA05012116A (es)
NO (1) NO20055997L (es)
NZ (1) NZ543232A (es)
RU (1) RU2005136537A (es)
SE (1) SE0301445D0 (es)
TW (1) TW200510312A (es)
UA (1) UA81309C2 (es)
UY (1) UY28318A1 (es)
WO (1) WO2004101520A1 (es)
ZA (1) ZA200509243B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY148880A (en) * 2006-10-20 2013-06-14 Astrazeneca Ab N-(2-hydroxyethyl)-n-methyl-4-(quinolin-8-yl(1-(thiazol-4-ylmethyl)piperidin-4-ylidene)methyl)benzamide, the process of making it as well as its use for the treatment of pain, anxiety and depression
WO2009035598A1 (en) * 2007-09-10 2009-03-19 Concert Pharmaceuticals, Inc. Deuterated pirfenidone
LT3233825T (lt) * 2014-12-19 2020-08-10 Pharmnovo Ab Diarilmetilideno piperidino dariniai ir jų naudojimas kaip delta opioidinių receptorių agonistų
WO2016099394A1 (en) * 2014-12-19 2016-06-23 Pharmnovo Ab Novel selective delta-opioid receptor agonists useful for the treatment of pain, anxiety and depression.
ES2920130T3 (es) * 2015-09-02 2022-08-01 Trevena Inc Compuestos moduladores del receptor opioide Delta que contienen heterocíclicos Aza de 6 miembros, métodos de uso y fabricación de los mismos
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