RU93058260A - Способ получения водорастворимых микронизированных веществ - Google Patents
Способ получения водорастворимых микронизированных веществInfo
- Publication number
- RU93058260A RU93058260A RU93058260/14A RU93058260A RU93058260A RU 93058260 A RU93058260 A RU 93058260A RU 93058260/14 A RU93058260/14 A RU 93058260/14A RU 93058260 A RU93058260 A RU 93058260A RU 93058260 A RU93058260 A RU 93058260A
- Authority
- RU
- Russia
- Prior art keywords
- substances
- producing water
- micronized
- micronized substances
- soluble
- Prior art date
Links
- 239000000126 substance Substances 0.000 title claims 5
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000002904 solvent Substances 0.000 claims 2
- 238000001035 drying Methods 0.000 claims 1
- 238000011010 flushing procedure Methods 0.000 claims 1
- 239000011261 inert gas Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Claims (1)
- Способ получения водорастворимых микронизированных веществ, которые можно получать, хранить и использовать, сохраняя аэродинамические свойства, необходимые для ингаляции таких веществ, осуществляется путем: а) в случае необходимости понижения содержания остаточной воды в микронизированном веществе путем высушивания необязательно при повышенной температуре и/или в вакууме; в) обработки высушенных микронизированных веществ растворителем и с) удаления остаточного растворителя путем выдерживания в сухом месте, например в вакууме, или путем продувки инертным газом.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9101090-0 | 1991-04-11 | ||
SE9101090A SE9101090D0 (sv) | 1991-04-11 | 1991-04-11 | Process for conditioning of water-soluble substances |
PCT/SE1992/000186 WO1992018110A1 (en) | 1991-04-11 | 1992-03-24 | Process for conditioning of water-soluble substances |
Publications (2)
Publication Number | Publication Date |
---|---|
RU93058260A true RU93058260A (ru) | 1996-10-10 |
RU2112507C1 RU2112507C1 (ru) | 1998-06-10 |
Family
ID=20382434
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU93058260A RU2112507C1 (ru) | 1991-04-11 | 1992-03-24 | Способ получения стабильных водорастворимых микронизированных веществ |
Country Status (28)
Country | Link |
---|---|
US (1) | US5562923A (ru) |
EP (3) | EP0680752B1 (ru) |
JP (2) | JP3400999B2 (ru) |
KR (1) | KR100216384B1 (ru) |
AT (2) | ATE137671T1 (ru) |
AU (1) | AU662519B2 (ru) |
BG (1) | BG61474B1 (ru) |
CA (1) | CA2106975C (ru) |
CZ (1) | CZ286936B6 (ru) |
DE (2) | DE69210601T2 (ru) |
DK (2) | DK0680752T3 (ru) |
EE (1) | EE02970B1 (ru) |
ES (2) | ES2086733T3 (ru) |
FI (1) | FI105388B (ru) |
GR (1) | GR3020602T3 (ru) |
HK (1) | HK52497A (ru) |
HU (1) | HU211116B (ru) |
IE (1) | IE921144A1 (ru) |
IS (1) | IS3834A (ru) |
NO (1) | NO311867B1 (ru) |
PL (1) | PL168232B1 (ru) |
PT (1) | PT680752E (ru) |
RO (1) | RO115779B1 (ru) |
RU (1) | RU2112507C1 (ru) |
SE (1) | SE9101090D0 (ru) |
SG (1) | SG43180A1 (ru) |
SK (1) | SK280310B6 (ru) |
WO (1) | WO1992018110A1 (ru) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9302777D0 (sv) * | 1993-08-27 | 1993-08-27 | Astra Ab | Process for conditioning substances |
US5874063A (en) * | 1991-04-11 | 1999-02-23 | Astra Aktiebolag | Pharmaceutical formulation |
US5980949A (en) * | 1994-10-03 | 1999-11-09 | Astra Aktiebolag | Formulation for inhalation |
US5983956A (en) * | 1994-10-03 | 1999-11-16 | Astra Aktiebolag | Formulation for inhalation |
CN1090935C (zh) * | 1995-02-28 | 2002-09-18 | 阿温蒂斯药物公司 | 哌啶子基烷醇化合物的药物组合物 |
US5654007A (en) * | 1995-06-07 | 1997-08-05 | Inhale Therapeutic Systems | Methods and system for processing dispersible fine powders |
GB9526392D0 (en) | 1995-12-22 | 1996-02-21 | Glaxo Group Ltd | Medicaments |
SE9700135D0 (sv) | 1997-01-20 | 1997-01-20 | Astra Ab | New formulation |
SE9700133D0 (sv) * | 1997-01-20 | 1997-01-20 | Astra Ab | New formulation |
EP2036544B1 (en) * | 1997-03-20 | 2016-12-28 | Merck Sharp & Dohme Corp. | Dosage form of powder agglomerates |
US6503537B2 (en) | 1997-03-20 | 2003-01-07 | Schering Corporation | Preparation of powder agglomerates |
US6495167B2 (en) | 1997-03-20 | 2002-12-17 | Schering Corporation | Preparation of powder agglomerates |
CN1159012C (zh) * | 1997-08-26 | 2004-07-28 | 阿旺蒂斯制药公司 | 用于组合哌啶子基烷醇-减充血剂的药物组合物 |
US20060165606A1 (en) | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
RS50182B (sr) * | 1997-09-29 | 2009-05-06 | Nektar Therapeutics, | Perforisane mikročestice i postupci za njihovu primenu |
FI105074B (fi) * | 1997-12-31 | 2000-06-15 | Leiras Oy | Farmaseuttisen formulaation valmistusmenetelmä |
US6287693B1 (en) | 1998-02-25 | 2001-09-11 | John Claude Savoir | Stable shaped particles of crystalline organic compounds |
SE9804000D0 (sv) | 1998-11-23 | 1998-11-23 | Astra Ab | New composition of matter |
GB9826284D0 (en) | 1998-12-01 | 1999-01-20 | Rhone Poulence Rorer Limited | Process |
GB9826286D0 (en) | 1998-12-01 | 1999-01-20 | Rhone Poulence Rorer Limited | Process |
US8722668B2 (en) * | 1998-12-23 | 2014-05-13 | Daryl W. Hochman | Methods and compositions for the treatment of neuropathic pain and neuropsychiatric disorders |
AR022695A1 (es) * | 1999-01-28 | 2002-09-04 | Schering Corp | PORTADOR SoLIDO PARTICULADO Y MÉTODO PARA PROVEER CONTROL DE LA PARTICULADA PARA LA DISTRIBUCIoN DE TAMANO DE PARTíCULAS Y DE CONTENIDO AMORFO CONVERTIBLE DURANTE SU PREPARACION |
US6623760B1 (en) | 1999-01-28 | 2003-09-23 | Schering Corporation | Method of preparing particles for agglomeration |
US7871598B1 (en) | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
US7309707B2 (en) | 2002-03-20 | 2007-12-18 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Crystalline micronisate, process for the manufacture thereof and use thereof for the preparation of a medicament |
US7244415B2 (en) | 2002-03-28 | 2007-07-17 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | HFA suspension formulations of an anhydrate |
US20040028746A1 (en) * | 2002-08-06 | 2004-02-12 | Sonke Svenson | Crystalline drug particles prepared using a controlled precipitation (recrystallization) process |
GB0228826D0 (en) * | 2002-12-11 | 2003-01-15 | Okpala Joseph | Hair technology in creating particles with improved delivery capabilities |
WO2004087102A2 (en) * | 2003-03-26 | 2004-10-14 | Teva Pharmaceutical Industries Ltd. | A process for preparing a pharmaceutical active ingredient with high specific surface area |
EA018356B1 (ru) * | 2003-06-13 | 2013-07-30 | Джон Клод Савуар | Микросферы эстрадиола и холестерина |
GB0323684D0 (en) | 2003-10-09 | 2003-11-12 | Jagotec Ag | Improvements in or relating to organic compounds |
CN1894095A (zh) * | 2003-10-17 | 2007-01-10 | 纳幕尔杜邦公司 | 箔对热塑性聚合物的粘合 |
US7544805B2 (en) | 2004-02-03 | 2009-06-09 | Chemagis Ltd. | Stable amorphous forms of montelukast sodium |
DE102004048390A1 (de) | 2004-10-01 | 2006-04-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Pulverinhalativa auf Basis modifizierter Laktosemischungen als Hilfsstoff |
DE102004048389A1 (de) | 2004-10-01 | 2006-04-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Modifizierung von Oberflächen von Laktose als Hilfsstoff zur Verwendung für Pulverinhalativa |
US20070286814A1 (en) * | 2006-06-12 | 2007-12-13 | Medispray Laboratories Pvt. Ltd. | Stable aerosol pharmaceutical formulations |
WO2009074662A2 (en) * | 2007-12-13 | 2009-06-18 | Novartis Ag | Organic compounds |
GB0918149D0 (en) | 2009-10-16 | 2009-12-02 | Jagotec Ag | Improved medicinal aerosol formulation |
WO2011110852A1 (en) | 2010-03-10 | 2011-09-15 | Astrazeneca Ab | Polymorphic forms of 6- [2- (4 -cyanophenyl) - 2h - pyrazol - 3 - yl] - 5 -methyl - 3 - oxo - 4 - (trifluoromethyl - phenyl) 3,4-dihydropyrazine-2-carboxylic acid ethylamide |
AU2012277514A1 (en) | 2011-06-29 | 2014-01-09 | Astrazeneca Ab | Crystalline form of indazolyl amide derivatives for the treatment glucocorticoid receptor mediated disorders |
CA2905542C (en) * | 2013-03-15 | 2022-05-03 | Pearl Therapeutics, Inc. | Methods and systems for conditioning of particulate crystalline materials |
WO2021219230A1 (en) | 2020-04-30 | 2021-11-04 | Paolo Fiorina | Antiviral treatment |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3978192A (en) * | 1971-09-23 | 1976-08-31 | Sussman Martin V | Method of drawing fibers using a microterraced drawing surface |
US4405598A (en) * | 1976-01-30 | 1983-09-20 | Fisons, Limited | Composition for treating asthma |
KR890000664B1 (ko) * | 1981-10-19 | 1989-03-22 | 바리 안소니 뉴우샘 | 미분된 베클로메타손 디프로피오네이트 일수화물의 제조방법 |
US4476130A (en) * | 1982-09-09 | 1984-10-09 | Riker Laboratories, Inc. | 3-(1H-Tetrazol-5-yl)-4H-pyrimido[2,1-b]benzoxazol-4-one compounds exhibiting anti-allergic activity |
EP0258258B1 (de) * | 1985-06-21 | 1989-03-29 | Gergely, Gerhard, Dr. | Verfahren und vorrichtung zur behandlung von prozessgut, sowie mit hilfe des verfahrens und/oder der vorrichtung hergestelltes reaktivprodukt |
IT1204826B (it) * | 1986-03-04 | 1989-03-10 | Chiesi Farma Spa | Composizioni farmaceutiche per inalazione |
KR100229754B1 (ko) * | 1989-11-24 | 1999-11-15 | 샬러 한스, 하우스 한스 루돌프 | 판크레아틴구형입자, 이의 제조방법 및 이를 함유하는 약제학적 조성물 |
US5145684A (en) * | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
-
1991
- 1991-04-11 SE SE9101090A patent/SE9101090D0/xx unknown
-
1992
- 1992-03-24 AU AU15347/92A patent/AU662519B2/en not_active Expired
- 1992-03-24 RO RO93-01336A patent/RO115779B1/ro unknown
- 1992-03-24 CA CA002106975A patent/CA2106975C/en not_active Expired - Lifetime
- 1992-03-24 SG SG1996004975A patent/SG43180A1/en unknown
- 1992-03-24 HU HU9302870A patent/HU211116B/hu unknown
- 1992-03-24 RU RU93058260A patent/RU2112507C1/ru active
- 1992-03-24 DE DE69210601T patent/DE69210601T2/de not_active Expired - Lifetime
- 1992-03-24 EP EP95111178A patent/EP0680752B1/en not_active Expired - Lifetime
- 1992-03-24 DE DE69232207T patent/DE69232207T2/de not_active Expired - Lifetime
- 1992-03-24 EP EP92850062A patent/EP0508969A1/en active Pending
- 1992-03-24 JP JP50719592A patent/JP3400999B2/ja not_active Expired - Lifetime
- 1992-03-24 AT AT92907877T patent/ATE137671T1/de active
- 1992-03-24 CZ CZ19932116A patent/CZ286936B6/cs not_active IP Right Cessation
- 1992-03-24 WO PCT/SE1992/000186 patent/WO1992018110A1/en active IP Right Grant
- 1992-03-24 DK DK95111178T patent/DK0680752T3/da active
- 1992-03-24 DK DK92907877.2T patent/DK0580648T3/da active
- 1992-03-24 SK SK1088-93A patent/SK280310B6/sk not_active IP Right Cessation
- 1992-03-24 EP EP92907877A patent/EP0580648B1/en not_active Expired - Lifetime
- 1992-03-24 PT PT95111178T patent/PT680752E/pt unknown
- 1992-03-24 PL PL92301008A patent/PL168232B1/pl unknown
- 1992-03-24 ES ES92907877T patent/ES2086733T3/es not_active Expired - Lifetime
- 1992-03-24 ES ES95111178T patent/ES2168322T3/es not_active Expired - Lifetime
- 1992-03-24 AT AT95111178T patent/ATE208613T1/de active
- 1992-03-24 KR KR1019930703065A patent/KR100216384B1/ko not_active IP Right Cessation
- 1992-04-10 IE IE114492A patent/IE921144A1/en not_active IP Right Cessation
- 1992-04-10 IS IS3834A patent/IS3834A/is unknown
-
1993
- 1993-10-06 NO NO19933575A patent/NO311867B1/no not_active IP Right Cessation
- 1993-10-08 FI FI934429A patent/FI105388B/fi not_active IP Right Cessation
- 1993-10-08 BG BG98147A patent/BG61474B1/bg unknown
-
1994
- 1994-11-17 EE EE9400417A patent/EE02970B1/xx unknown
-
1995
- 1995-06-07 US US08/479,494 patent/US5562923A/en not_active Expired - Lifetime
-
1996
- 1996-07-23 GR GR960401961T patent/GR3020602T3/el unknown
-
1997
- 1997-04-24 HK HK52497A patent/HK52497A/xx not_active IP Right Cessation
-
2002
- 2002-11-29 JP JP2002347368A patent/JP2003155228A/ja active Pending
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