RU2017128512A - Антитела к теофиллину и способы их применения - Google Patents
Антитела к теофиллину и способы их применения Download PDFInfo
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- RU2017128512A RU2017128512A RU2017128512A RU2017128512A RU2017128512A RU 2017128512 A RU2017128512 A RU 2017128512A RU 2017128512 A RU2017128512 A RU 2017128512A RU 2017128512 A RU2017128512 A RU 2017128512A RU 2017128512 A RU2017128512 A RU 2017128512A
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- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 title claims 3
- 229960000278 theophylline Drugs 0.000 title claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 11
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 4
- 125000000539 amino acid group Chemical group 0.000 claims 4
- 239000004475 Arginine Substances 0.000 claims 2
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 2
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 108091007491 NSP3 Papain-like protease domains Proteins 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229940126601 medicinal product Drugs 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Claims (19)
1. Антитело к теофиллину, содержащее: (а) гипервариабельный участок тяжелой цепи HVR-H3, содержащий аминокислотную последовательность SEQ ID NO: 11, (б) гипервариабельный участок легкой цепи HVR-L3, содержащий аминокислотную последовательность SEQ ID NO: 15, и (в) HVR-H2, содержащий аминокислотную последовательность SEQ ID NO: 10.
2. Антитело по п. 1, содержащее (а) HVR-H1, содержащий аминокислотную последовательность SEQ ID NO: 09, (б) HVR-H2, содержащий аминокислотную последовательность SEQ ID NO: 10, и (в) HVR-H3, содержащий аминокислотную последовательность SEQ ID NO: 11.
3. Антитело по любому из пп. 1-2, содержащее (а) HVR-L1, содержащий аминокислотную последовательность SEQ ID NO: 13, (б) HVR-L2, содержащий аминокислотную последовательность SEQ ID NO: 14, и (в) HVR-L3, содержащий аминокислотную последовательность SEQ ID NO: 15.
4. Антитело по любому из пп. 1-3, отличающееся тем, что оно представляет собой гуманизированное антитело и содержит в положении 71 вариабельного домена тяжелой цепи, согласно нумерации по Кабату, аминокислотный остаток аргинин.
5. Антитело по любому из пп. 1-4, отличающееся тем, что оно представляет собой гуманизированное антитело и содержит в положении 46 вариабельного домена легкой цепи, согласно нумерации по Кабату, аминокислотный остаток лейцин.
6. Антитело по любому из пп. 1-5, содержащее:
(a) последовательность вариабельного домена тяжелой цепи VH, идентичную по меньшей мере на 95% аминокислотной последовательности SEQ ID NO: 12;
(б) последовательность вариабельного домена легкой цепи VL, идентичную по меньшей мере на 95% аминокислотной последовательности SEQ ID NO: 16; или
(в) последовательность VH как в (а) и последовательность VL как в (б),
где аминокислотный остаток в положении 71 вариабельного домена тяжелой цепи, согласно нумерации по Кабату, представляет собой аргинин, а аминокислотный остаток в положении 46 вариабельного домена легкой цепи, согласно нумерации по Кабату, представляет собой лейцин.
7. Антитело по п. 4, содержащее последовательность VH, представленную SEQ ID NO: 12.
8. Антитело по любому из пп. 4 или 7, содержащее последовательность VL, представленную SEQ ID NO: 16.
9. Антитело, содержащее последовательность VH, представленную SEQ ID NO: 12, и последовательность VL, представленную SEQ ID NO: 16.
10. Антитело по любому из пп. 1-9, представляющее собой полноразмерное антитело IgG1 или полноразмерное антитело IgG4.
11. Антитело по любому из пп. 1-10, представляющее собой моноклональное антитело.
12. Антитело по любому из пп. 1-11, представляющее собой фрагмент антитела, связывающийся с теофиллином.
13. Фармацевтическая композиция, содержащая антитело по любому из пп. 1-12 и фармацевтически приемлемый носитель.
14. Антитело по любому из пп. 1-12 для применения в качестве лекарственного средства.
15. Применение антитела по любому из пп. 1-12 при изготовлении лекарственного средства.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12174958 | 2012-07-04 | ||
| EP12174958.4 | 2012-07-04 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015102068A Division RU2630664C2 (ru) | 2012-07-04 | 2013-07-04 | Антитела к теофиллину и способы их применения |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2017128512A true RU2017128512A (ru) | 2019-02-15 |
Family
ID=48794057
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2017128512A RU2017128512A (ru) | 2012-07-04 | 2013-07-04 | Антитела к теофиллину и способы их применения |
| RU2015102068A RU2630664C2 (ru) | 2012-07-04 | 2013-07-04 | Антитела к теофиллину и способы их применения |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015102068A RU2630664C2 (ru) | 2012-07-04 | 2013-07-04 | Антитела к теофиллину и способы их применения |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US9925272B2 (ru) |
| EP (2) | EP3138578B1 (ru) |
| JP (2) | JP6324376B2 (ru) |
| KR (1) | KR20150023938A (ru) |
| CN (2) | CN107082810B (ru) |
| BR (1) | BR112014030843A2 (ru) |
| CA (1) | CA2872184A1 (ru) |
| DK (1) | DK2869837T3 (ru) |
| ES (1) | ES2600154T3 (ru) |
| HK (1) | HK1203354A1 (ru) |
| HU (1) | HUE029435T2 (ru) |
| MX (1) | MX353951B (ru) |
| PL (1) | PL2869837T3 (ru) |
| RU (2) | RU2017128512A (ru) |
| SI (1) | SI2869837T1 (ru) |
| WO (1) | WO2014006118A1 (ru) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112014030844A2 (pt) | 2012-07-04 | 2019-10-15 | Hoffmann La Roche | anticorpo anti-biotina humanizado, formulação farmacêutica e uso do anticorpo |
| KR102090849B1 (ko) | 2012-07-04 | 2020-03-19 | 에프. 호프만-라 로슈 아게 | 공유 결합된 항원-항체 접합체 |
| EP3089758B1 (en) | 2014-01-03 | 2021-01-27 | F.Hoffmann-La Roche Ag | Covalently linked helicar-anti-helicar antibody conjugates and uses thereof |
| EP3960768A1 (en) | 2014-01-03 | 2022-03-02 | F. Hoffmann-La Roche AG | Bispecific anti-hapten/anti-blood brain barrier receptor antibodies, complexes thereof and their use as blood brain barrier shuttles |
| EP3089759B1 (en) | 2014-01-03 | 2018-12-05 | F. Hoffmann-La Roche AG | Covalently linked polypeptide toxin-antibody conjugates |
| KR20170026362A (ko) | 2014-06-26 | 2017-03-08 | 에프. 호프만-라 로슈 아게 | 항-ｂｒｄｕ 항체 및 사용 방법 |
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2013
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- 2013-07-04 HU HUE13737564A patent/HUE029435T2/en unknown
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- 2013-07-04 RU RU2015102068A patent/RU2630664C2/ru not_active IP Right Cessation
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| HUE029435T2 (en) | 2017-02-28 |
| WO2014006118A1 (en) | 2014-01-09 |
| CA2872184A1 (en) | 2014-01-09 |
| JP2015527983A (ja) | 2015-09-24 |
| CN107082810A (zh) | 2017-08-22 |
| JP6549278B2 (ja) | 2019-07-24 |
| RU2630664C2 (ru) | 2017-09-11 |
| JP2018138561A (ja) | 2018-09-06 |
| CN104394886B (zh) | 2017-05-24 |
| RU2015102068A (ru) | 2016-08-20 |
| PL2869837T3 (pl) | 2017-03-31 |
| EP2869837A1 (en) | 2015-05-13 |
| EP3138578B1 (en) | 2022-01-12 |
| MX353951B (es) | 2018-02-07 |
| US20150238628A1 (en) | 2015-08-27 |
| SI2869837T1 (sl) | 2016-12-30 |
| ES2600154T3 (es) | 2017-02-07 |
| KR20150023938A (ko) | 2015-03-05 |
| DK2869837T3 (en) | 2016-09-26 |
| EP3138578A1 (en) | 2017-03-08 |
| CN107082810B (zh) | 2020-12-25 |
| JP6324376B2 (ja) | 2018-05-16 |
| BR112014030843A2 (pt) | 2019-10-15 |
| EP2869837B1 (en) | 2016-09-14 |
| CN104394886A (zh) | 2015-03-04 |
| MX2014014381A (es) | 2015-02-05 |
| US9925272B2 (en) | 2018-03-27 |
| HK1203354A1 (en) | 2015-10-30 |
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