RU2011143905A - ПОЛИСПЕЦИФИЧНЫЕ АНТИТЕЛА, ВКЛЮЧАЮЩИЕ АНТИТЕЛА ПОЛНОЙ ДЛИНЫ И ОДНОЦЕПОЧЕЧНЫЕ ФРАГМЕНТЫ Fab - Google Patents
ПОЛИСПЕЦИФИЧНЫЕ АНТИТЕЛА, ВКЛЮЧАЮЩИЕ АНТИТЕЛА ПОЛНОЙ ДЛИНЫ И ОДНОЦЕПОЧЕЧНЫЕ ФРАГМЕНТЫ Fab Download PDFInfo
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Abstract
1. Полиспецифичное антитело, включающееа) антитело полной длины, специфически связывающееся с первым антигеном и состоящее из двух тяжелых цепей антитела и двух легких цепей антитела, иб) один или несколько одноцепочечных фрагментов Fab, связывающихся с одним или несколькими дополнительными антигенами,в котором указанные одноцепочечные Fab-фрагменты по пункту б) соединены с указанным антителом полной длины по пункту а) через пептидный коннектор с С- или N-конца тяжелой или легкой цепи указанного антитела полной длины.2. Полиспецифичное антитело по п.1, включающееа) антитело полной длины, специфически связывающееся с первым антигеном и состоящее из двух тяжелых цепей антитела и двух легких цепей антитела, иб) от одного до четырех одноцепочечных фрагментов Fab, которые связывают от одного до четырех дополнительных антигенов,в котором указанные одноцепочечные фрагменты Fab по пункту б) гибридизированы с указанным антителом полной длины по пункту а) через пептидный коннектор с С- или N-конца тяжелой или легкой цепи указанного антитела полной длины.3. Полиспецифичное антитело по п.1 или 2, в котором один или два одноцепочечных фрагмента Fab, связывающихся со вторым антигеном, гибридизированы с указанным антителом полной длины через пептидный коннектор с С-конца тяжелых цепей указанного антитела полной длины.4. Полиспецифичное антитело по п.1 или 2, в котором один одноцепочечный фрагмент Fab, связывающийся со вторым антигеном, соединен с указанным антителом полной длины через пептидный коннектор с С-конца одной тяжелой цепи или одной легкой цепи указанного антитела полной длины.5. Полиспецифичное антитело по п.1 или 2, в которо�
Claims (8)
1. Полиспецифичное антитело, включающее
а) антитело полной длины, специфически связывающееся с первым антигеном и состоящее из двух тяжелых цепей антитела и двух легких цепей антитела, и
б) один или несколько одноцепочечных фрагментов Fab, связывающихся с одним или несколькими дополнительными антигенами,
в котором указанные одноцепочечные Fab-фрагменты по пункту б) соединены с указанным антителом полной длины по пункту а) через пептидный коннектор с С- или N-конца тяжелой или легкой цепи указанного антитела полной длины.
2. Полиспецифичное антитело по п.1, включающее
а) антитело полной длины, специфически связывающееся с первым антигеном и состоящее из двух тяжелых цепей антитела и двух легких цепей антитела, и
б) от одного до четырех одноцепочечных фрагментов Fab, которые связывают от одного до четырех дополнительных антигенов,
в котором указанные одноцепочечные фрагменты Fab по пункту б) гибридизированы с указанным антителом полной длины по пункту а) через пептидный коннектор с С- или N-конца тяжелой или легкой цепи указанного антитела полной длины.
3. Полиспецифичное антитело по п.1 или 2, в котором один или два одноцепочечных фрагмента Fab, связывающихся со вторым антигеном, гибридизированы с указанным антителом полной длины через пептидный коннектор с С-конца тяжелых цепей указанного антитела полной длины.
4. Полиспецифичное антитело по п.1 или 2, в котором один одноцепочечный фрагмент Fab, связывающийся со вторым антигеном, соединен с указанным антителом полной длины через пептидный коннектор с С-конца одной тяжелой цепи или одной легкой цепи указанного антитела полной длины.
5. Полиспецифичное антитело по п.1 или 2, в котором два идентичных одноцепочечных фрагмента Fab VL-CL-линкер-VH-СН1 или VH-CH1-линкер-VL-CL, связывающихся со вторым антигеном, гибридизированы своими N-концами с указанным антителом полной длины через пептидный коннектор с двух С-концов двух тяжелых цепей или с двух С-концов двух легких цепей указанного антитела полной длины.
6. Полиспецифичное антитело по п.1 или 2, в котором два идентичных одноцепочечных фрагмента Fab VL-CL-линкер-VH-CH1 или VH-CH1-линкер-VL-CL, связывающихся со вторым антигеном, гибридизированы своими С-концами с указанным антителом полной длины через пептидный коннектор с двух N-концов двух тяжелых цепей или с двух N-концах двух легких цепей указанного антитела полной длины.
7. Фармацевтическая композиция, включающая антитело по пп.1-6.
8. Нуклеиновая кислота, кодирующая полиспецифичное антитело по п.6.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09004909 | 2009-04-02 | ||
| EP09004909.9 | 2009-04-02 | ||
| PCT/EP2010/002004 WO2010112193A1 (en) | 2009-04-02 | 2010-03-30 | Multispecific antibodies comprising full length antibodies and single chain fab fragments |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2011143905A true RU2011143905A (ru) | 2013-05-10 |
| RU2598248C2 RU2598248C2 (ru) | 2016-09-20 |
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| RU2011143905/10A RU2598248C2 (ru) | 2009-04-02 | 2010-03-30 | Полиспецифичные антитела, включающие антитела полной длины и одноцепочечные фрагменты fab |
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| Country | Link |
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| US (1) | US9382323B2 (ru) |
| EP (1) | EP2414391B1 (ru) |
| JP (1) | JP5501439B2 (ru) |
| KR (1) | KR101431318B1 (ru) |
| CN (1) | CN102369215B (ru) |
| AR (1) | AR076018A1 (ru) |
| AU (1) | AU2010230563A1 (ru) |
| BR (1) | BRPI1014089A2 (ru) |
| CA (1) | CA2756244A1 (ru) |
| CL (1) | CL2011002380A1 (ru) |
| HK (1) | HK1167669A1 (ru) |
| IL (1) | IL214756A0 (ru) |
| MX (1) | MX2011010159A (ru) |
| PE (1) | PE20120591A1 (ru) |
| RU (1) | RU2598248C2 (ru) |
| SG (1) | SG175004A1 (ru) |
| TW (1) | TW201040265A (ru) |
| WO (1) | WO2010112193A1 (ru) |
| ZA (1) | ZA201106666B (ru) |
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|---|---|
| CN102369215B (zh) | 2015-01-21 |
| US9382323B2 (en) | 2016-07-05 |
| EP2414391B1 (en) | 2018-11-28 |
| SG175004A1 (en) | 2011-11-28 |
| BRPI1014089A2 (pt) | 2016-04-19 |
| JP5501439B2 (ja) | 2014-05-21 |
| MX2011010159A (es) | 2011-10-17 |
| EP2414391A1 (en) | 2012-02-08 |
| AR076018A1 (es) | 2011-05-11 |
| WO2010112193A1 (en) | 2010-10-07 |
| US20100256338A1 (en) | 2010-10-07 |
| IL214756A0 (en) | 2011-11-30 |
| AU2010230563A1 (en) | 2011-09-22 |
| TW201040265A (en) | 2010-11-16 |
| JP2012522493A (ja) | 2012-09-27 |
| HK1167669A1 (en) | 2012-12-07 |
| CA2756244A1 (en) | 2010-10-07 |
| KR20110130525A (ko) | 2011-12-05 |
| PE20120591A1 (es) | 2012-05-23 |
| ZA201106666B (en) | 2012-05-30 |
| KR101431318B1 (ko) | 2014-08-20 |
| CN102369215A (zh) | 2012-03-07 |
| CL2011002380A1 (es) | 2012-06-15 |
| RU2598248C2 (ru) | 2016-09-20 |
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