RU2008143112A - Способ детоксикации микотоксинов - Google Patents
Способ детоксикации микотоксинов Download PDFInfo
- Publication number
- RU2008143112A RU2008143112A RU2008143112/13A RU2008143112A RU2008143112A RU 2008143112 A RU2008143112 A RU 2008143112A RU 2008143112/13 A RU2008143112/13 A RU 2008143112/13A RU 2008143112 A RU2008143112 A RU 2008143112A RU 2008143112 A RU2008143112 A RU 2008143112A
- Authority
- RU
- Russia
- Prior art keywords
- mycotoxins
- cell according
- cell
- detoxification
- deletions
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
- C12N9/1062—Sucrose synthase (2.4.1.13)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8291—Hormone-influenced development
- C12N15/8298—Brassinosteroids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Cephalosporin Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
1. Рекомбинантная клетка, резистентная к микотоксинам, в особенности к трихотеценам, включающая гетерологичную глюкозилтрансферазу, или обладающая повышенной активностью по экспрессии эндогенной глюкозилтрансферазы за счет трансгенной экспрессии регуляторных элементов и по меньшей мере один, предпочтительно три или более ABC-переносчиков, которые обладают сниженной активностью или инактивированной активностью, в особенности делециями в pdr5. ! 2. Клетка по п.1, отличающаяся тем, что представляет собой растительную или дрожжевую клетку. !3. Клетка по любому из пп.1 или 2, отличающаяся тем, что имеет делеции в pdr5, pdr10, snq2, yor1, pdr15, ayt1 или сочетания таких делеций. ! 4. Применение клетки по любому из пп.1-3 для детоксикации микотоксинов. ! 5. Применение клетки по п.4, отличающееся тем, что указанное растение или растительная клетка обладает резистентностью к Fusarium. ! 6. Применение клетки по любому из пп.1-3 для детоксикации микотоксина в микотоксин-содержащих растворах или суспензиях, в особенности для детоксикации трихотеценов в сельском хозяйстве или в пивоварении. ! 7. Применение клетки по любому из пп.1-3 для продуцирования глюкозилированных микотоксинов, в частности глюкозилированных DON или 15-ADON.
Claims (7)
1. Рекомбинантная клетка, резистентная к микотоксинам, в особенности к трихотеценам, включающая гетерологичную глюкозилтрансферазу, или обладающая повышенной активностью по экспрессии эндогенной глюкозилтрансферазы за счет трансгенной экспрессии регуляторных элементов и по меньшей мере один, предпочтительно три или более ABC-переносчиков, которые обладают сниженной активностью или инактивированной активностью, в особенности делециями в pdr5.
2. Клетка по п.1, отличающаяся тем, что представляет собой растительную или дрожжевую клетку.
3. Клетка по любому из пп.1 или 2, отличающаяся тем, что имеет делеции в pdr5, pdr10, snq2, yor1, pdr15, ayt1 или сочетания таких делеций.
4. Применение клетки по любому из пп.1-3 для детоксикации микотоксинов.
5. Применение клетки по п.4, отличающееся тем, что указанное растение или растительная клетка обладает резистентностью к Fusarium.
6. Применение клетки по любому из пп.1-3 для детоксикации микотоксина в микотоксин-содержащих растворах или суспензиях, в особенности для детоксикации трихотеценов в сельском хозяйстве или в пивоварении.
7. Применение клетки по любому из пп.1-3 для продуцирования глюкозилированных микотоксинов, в частности глюкозилированных DON или 15-ADON.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03450194A EP1510573A1 (en) | 2003-09-01 | 2003-09-01 | Method for detoxification of mycotoxins |
EP03450194.0 | 2003-09-01 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2006110557/13A Division RU2347810C2 (ru) | 2003-09-01 | 2004-09-01 | Способ детоксикации микотоксинов |
Publications (1)
Publication Number | Publication Date |
---|---|
RU2008143112A true RU2008143112A (ru) | 2010-05-10 |
Family
ID=34089804
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2006110557/13A RU2347810C2 (ru) | 2003-09-01 | 2004-09-01 | Способ детоксикации микотоксинов |
RU2008143112/13A RU2008143112A (ru) | 2003-09-01 | 2008-10-30 | Способ детоксикации микотоксинов |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2006110557/13A RU2347810C2 (ru) | 2003-09-01 | 2004-09-01 | Способ детоксикации микотоксинов |
Country Status (10)
Country | Link |
---|---|
US (1) | US20060183202A1 (ru) |
EP (3) | EP1510573A1 (ru) |
AT (1) | ATE380862T1 (ru) |
AU (1) | AU2004269152A1 (ru) |
CA (1) | CA2536467A1 (ru) |
DE (1) | DE602004010682T2 (ru) |
MX (1) | MXPA06002128A (ru) |
NZ (1) | NZ546027A (ru) |
RU (2) | RU2347810C2 (ru) |
WO (1) | WO2005021740A1 (ru) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2100962A1 (en) | 2008-03-12 | 2009-09-16 | Biogemma | Plants having improved resistance to pathogens |
ES2626245T3 (es) * | 2009-06-04 | 2017-07-24 | Nippon Soda Co., Ltd. | Método para la producción de una bebida de malta fermentada usando cereales tratados con metil-tiofanato |
SG11201401927PA (en) | 2011-11-23 | 2014-09-26 | Evolva Sa | Methods and materials for enzymatic synthesis of mogroside compounds |
WO2014086842A1 (en) | 2012-12-04 | 2014-06-12 | Evolva Sa | Methods and materials for biosynthesis of mogroside compounds |
SG11201702123SA (en) | 2014-10-01 | 2017-04-27 | Evolva Sa | Methods and materials for biosynthesis of mogroside compounds |
CN104396973B (zh) * | 2014-10-31 | 2016-03-23 | 云南省农业科学院农业环境资源研究所 | 单端孢菌素在抗烟草病原真菌中的用途 |
CN108220264B (zh) * | 2016-12-22 | 2021-06-22 | 中国科学院天津工业生物技术研究所 | 一种糖基转移酶在生物合成红景天苷中的应用 |
CN108244348B (zh) * | 2016-12-29 | 2021-07-06 | 中粮营养健康研究院有限公司 | 酶复合制剂、饲料或添加剂以及脱除呕吐毒素的方法 |
EP3638804A1 (en) | 2017-06-15 | 2020-04-22 | Evolva SA | Production of mogroside compounds in recombinant hosts |
CN110286190B (zh) * | 2019-06-26 | 2024-03-22 | 山东农业大学 | 一种同时测定don及多种don生物转化产物的方法 |
CA3176479A1 (en) * | 2020-03-05 | 2021-09-10 | Shandong Agricultural University | Nucleic acid molecule, and polypeptide having epoxy group-removal catalytic activity and use thereof |
CN112725362B (zh) * | 2020-12-01 | 2022-11-22 | 广东省微生物研究所(广东省微生物分析检测中心) | 一种露湿漆斑菌a553抗单端孢霉烯自我保护基因gnat11及其应用 |
CN112626046B (zh) * | 2020-12-24 | 2022-11-22 | 广东省微生物研究所(广东省微生物分析检测中心) | 一种能抗b型和d型单端孢霉烯族毒素的酰基转移酶gantb及其应用 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4954444A (en) * | 1987-03-02 | 1990-09-04 | E. I. Du Pont De Nemours And Company | Enzyme immobilization and bioaffinity separations with perfluorocarbon polymer-based supports |
GB9611420D0 (en) * | 1996-05-31 | 1996-08-07 | Univ York | Use of salicyclic acid-glucosyl transferase |
US5959180A (en) * | 1997-02-07 | 1999-09-28 | The United States Of America As Represented By The Secretary Of Agriculture | DNA sequences from potato encoding solanidine UDP-glucose glucosyltransferase and use to reduce glycoalkaloids in solanaceous plants |
FR2780415A1 (fr) * | 1998-06-26 | 1999-12-31 | Rhone Poulenc Agrochimie | Procede enzymatique de glucosylation de derives aromatiques |
-
2003
- 2003-09-01 EP EP03450194A patent/EP1510573A1/en not_active Withdrawn
-
2004
- 2004-02-13 EP EP04450028A patent/EP1510585A1/en not_active Withdrawn
- 2004-09-01 AT AT04786904T patent/ATE380862T1/de not_active IP Right Cessation
- 2004-09-01 EP EP04786904A patent/EP1660649B1/en not_active Expired - Lifetime
- 2004-09-01 DE DE602004010682T patent/DE602004010682T2/de not_active Expired - Fee Related
- 2004-09-01 CA CA002536467A patent/CA2536467A1/en not_active Abandoned
- 2004-09-01 NZ NZ546027A patent/NZ546027A/en unknown
- 2004-09-01 RU RU2006110557/13A patent/RU2347810C2/ru not_active IP Right Cessation
- 2004-09-01 AU AU2004269152A patent/AU2004269152A1/en not_active Abandoned
- 2004-09-01 US US10/570,032 patent/US20060183202A1/en not_active Abandoned
- 2004-09-01 WO PCT/EP2004/009728 patent/WO2005021740A1/en active IP Right Grant
-
2006
- 2006-02-23 MX MXPA06002128 patent/MXPA06002128A/es active IP Right Grant
-
2008
- 2008-10-30 RU RU2008143112/13A patent/RU2008143112A/ru not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO2005021740A1 (en) | 2005-03-10 |
EP1510573A1 (en) | 2005-03-02 |
DE602004010682T2 (de) | 2009-03-26 |
US20060183202A1 (en) | 2006-08-17 |
MXPA06002128A (es) | 2006-08-01 |
EP1510585A1 (en) | 2005-03-02 |
ATE380862T1 (de) | 2007-12-15 |
NZ546027A (en) | 2008-05-30 |
DE602004010682D1 (de) | 2008-01-24 |
RU2347810C2 (ru) | 2009-02-27 |
EP1660649B1 (en) | 2007-12-12 |
CA2536467A1 (en) | 2005-03-10 |
EP1660649A1 (en) | 2006-05-31 |
RU2006110557A (ru) | 2006-07-27 |
AU2004269152A1 (en) | 2005-03-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA93 | Acknowledgement of application withdrawn (no request for examination) |
Effective date: 20120110 |