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RU2006126541A - Биомаркеры чуствительности пролиферативных заболеваний к ингибиторам mtor - Google Patents

Биомаркеры чуствительности пролиферативных заболеваний к ингибиторам mtor Download PDF

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Publication number
RU2006126541A
RU2006126541A RU2006126541/15A RU2006126541A RU2006126541A RU 2006126541 A RU2006126541 A RU 2006126541A RU 2006126541/15 A RU2006126541/15 A RU 2006126541/15A RU 2006126541 A RU2006126541 A RU 2006126541A RU 2006126541 A RU2006126541 A RU 2006126541A
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RU
Russia
Prior art keywords
mtor inhibitor
proliferative disease
subject
treatment
sensitivity
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RU2006126541/15A
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English (en)
Inventor
Анне БУЛАЙ (FR)
Анне БУЛАЙ
Хайди ЛАНЕ (CH)
Хайди Лане
Совэ-Мишель МАЙРА (FR)
Совэ-Мишель МАЙРА
Теренс О`РЕЙЛЛИ (CH)
Теренс О`РЕЙЛЛИ
Original Assignee
Новартис АГ (CH)
Новартис Аг
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Application filed by Новартис АГ (CH), Новартис Аг filed Critical Новартис АГ (CH)
Publication of RU2006126541A publication Critical patent/RU2006126541A/ru

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57496—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving intracellular compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
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  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Claims (17)

1. Применение S6 в качестве биомаркера для определения чувствительности пролиферативного заболевания субъекта к лечению ингибитором mTOR.
2. Применение S6 в качестве биомаркера с целью отбора субъектов больных пролиферативным заболеванием для лечения ингибитором mTOR.
3. Применение по п.1 или 2, включающее применение уровня экспрессии и/или состояния фосфорилирования S6.
4. Применение по п.1 или 2, включающее использование уровня экспрессии фосфорилированного белка S6.
5. Применение по любому из п.1 или 2, при котором пролиферативное заболевание является раком.
6. Применение по одному из п.1 или 2, при котором ингибитор mTOR является рапамицином или производным рапамицина.
7. Применение по одному из п.1 или 2, при котором производное рапамицина является 40-О-(2-гидроксиэтил)рапамицином.
8. Применение по одному из п.1 или 2, при котором повышенная экспрессия фосфорилированного белка S6 относительно контроля является прогнозом чувствительности пролиферативного заболевания к лечению ингибитором mTOR.
9. Способ определения чувствительности пролиферативного заболевания субъекта к лечению ингибитором mTOR, включающий определение уровня экспрессии и/или состояния фосфорилирования S6 в образце, взятом у субъекта.
10. Способ по п.9, в котором пролиферативное заболевание является раком.
11. Способ по п.9, в котором ингибитор mTOR является рапамицином или производным рапамицина.
12. Способ по п.9, в котором производное рапамицина является 40-О-(2-гидроксиэтил)рапамицином.
13. Способ по п.9, включающее установление уровня экспрессии фосфорилирования белка S6.
14. Способ по п.9, в котором образец берется из раковой опухоли субъекта.
15. Способ по п.9, в котором повышенная экспрессия фосфорилированного белка S6 относительно контроля является прогнозом чувствительности пролиферативного заболевания к лечению ингибитором mTOR.
16. Способ выбора субъектов больных пролиферативным заболеванием для лечения ингибитором mTOR, включающий определение чувствительности пролиферативного заболевания к лечению ингибитором mTOR у каждого субъекта способом, описанным в п.9, и выбор тех субъектов, которые показали повышенную экспрессию фосфорилированного S6, для лечения ингибитором mTOR.
17. Способ лечения пролиферативного заболевания субъекта, нуждающегося в этом, включающий определение уровня экспрессии фосфорилированного S6 в образце, взятом у субъекта, способом, описанным в п.9, и лечение субъекта ингибитором mTOR, если уровень экспрессии фосфорилированного S6 повышен.
RU2006126541/15A 2003-12-22 2004-12-21 Биомаркеры чуствительности пролиферативных заболеваний к ингибиторам mtor RU2006126541A (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53170003P 2003-12-22 2003-12-22
US60/531,700 2003-12-22

Publications (1)

Publication Number Publication Date
RU2006126541A true RU2006126541A (ru) 2008-01-27

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US (2) US20070167478A1 (ru)
EP (1) EP1709449A1 (ru)
JP (1) JP2007519897A (ru)
KR (1) KR20060123367A (ru)
CN (1) CN1898568A (ru)
AU (1) AU2004309499A1 (ru)
BR (1) BRPI0418022A (ru)
CA (1) CA2549829A1 (ru)
MX (1) MXPA06007174A (ru)
RU (1) RU2006126541A (ru)
WO (1) WO2005064343A1 (ru)

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Publication number Priority date Publication date Assignee Title
US7754208B2 (en) 2001-01-17 2010-07-13 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
JP5740076B2 (ja) 2005-07-25 2015-06-24 エマージェント・プロダクト・ディベロップメント・シアトル・エルエルシー Ｃｄ３７特異的及びｃｄ２０特異的結合分子を用いたｂ細胞の減少
WO2007047754A2 (en) * 2005-10-18 2007-04-26 George Mason Intellectual Properties, Inc. Mtor pathway theranostic
NO20220050A1 (no) 2005-11-21 2008-08-12 Novartis Ag Neuroendokrin tumorbehandling
MX2010011057A (es) 2008-04-11 2010-11-12 Trubion Pharmaceuticals Inc Inmunoterapeutico de cd37 y combinacion con quimioterapeutico bifuncional del mismo.
AU2012320465B2 (en) * 2011-10-07 2016-03-03 Cellzome Limited Morpholino substituted bicyclic pyrimidine urea or carbamate derivatives as mTOR inhibitors

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WO2002046471A2 (en) * 2000-12-08 2002-06-13 Board Of Regents, The University Of Texas System Methods and compositions for the identification, assessment and therapy of human cancers
US6969592B2 (en) * 2001-09-26 2005-11-29 Pharmacia Italia S.P.A. Method for predicting the sensitivity to chemotherapy
GB0124577D0 (en) * 2001-10-12 2001-12-05 Novartis Forschungsstiftung Novel methods
JP2003180368A (ja) * 2001-12-19 2003-07-02 Pharma Design Inc 癌患者に対する放射線治療の有効性の予測方法
WO2004020582A2 (en) * 2002-08-15 2004-03-11 Functional Genetics, Inc. Mammalian genes involved in rapamycin resistance and tumorgenesis: rapr6 genes
AU2003291736A1 (en) * 2002-11-05 2004-06-03 Cell Signaling Technology, Inc. Methods and materials for examining pathways associated with glioblastoma progression

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CA2549829A1 (en) 2005-07-14
BRPI0418022A (pt) 2007-04-17
EP1709449A1 (en) 2006-10-11
US20070167478A1 (en) 2007-07-19
KR20060123367A (ko) 2006-12-01
CN1898568A (zh) 2007-01-17
JP2007519897A (ja) 2007-07-19
WO2005064343A1 (en) 2005-07-14
AU2004309499A1 (en) 2005-07-14
US20080214596A1 (en) 2008-09-04
MXPA06007174A (es) 2006-08-23

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