PT2657233E - Composto de alcinil-benzeno substituído nas posições 3 e 5 e um seu sal - Google Patents
Composto de alcinil-benzeno substituído nas posições 3 e 5 e um seu sal Download PDFInfo
- Publication number
- PT2657233E PT2657233E PT137289187T PT13728918T PT2657233E PT 2657233 E PT2657233 E PT 2657233E PT 137289187 T PT137289187 T PT 137289187T PT 13728918 T PT13728918 T PT 13728918T PT 2657233 E PT2657233 E PT 2657233E
- Authority
- PT
- Portugal
- Prior art keywords
- disubstituted
- salt
- alkynylbenzene
- compound
- alkynylbenzene compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012009467 | 2012-01-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2657233E true PT2657233E (pt) | 2014-10-24 |
Family
ID=48799233
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT137289187T PT2657233E (pt) | 2012-01-19 | 2013-01-17 | Composto de alcinil-benzeno substituído nas posições 3 e 5 e um seu sal |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US9108973B2 (pt) |
| EP (1) | EP2657233B1 (pt) |
| JP (1) | JP5355825B1 (pt) |
| KR (1) | KR101623286B1 (pt) |
| CN (1) | CN103958512B (pt) |
| AU (1) | AU2013210403B2 (pt) |
| BR (1) | BR112014017749B1 (pt) |
| CA (1) | CA2854093C (pt) |
| DK (1) | DK2657233T3 (pt) |
| ES (1) | ES2516392T3 (pt) |
| FI (1) | FIC20230038I1 (pt) |
| FR (1) | FR23C1050I1 (pt) |
| HK (1) | HK1198164A1 (pt) |
| HU (1) | HUS2300043I1 (pt) |
| MX (1) | MX351513B (pt) |
| MY (1) | MY171055A (pt) |
| NL (1) | NL301254I2 (pt) |
| NO (1) | NO2023046I1 (pt) |
| PL (1) | PL2657233T3 (pt) |
| PT (1) | PT2657233E (pt) |
| RU (1) | RU2576384C1 (pt) |
| SG (1) | SG2014009286A (pt) |
| TW (1) | TWI508964B (pt) |
| WO (1) | WO2013108809A1 (pt) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012088266A2 (en) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3 |
| JP5873656B2 (ja) | 2011-06-13 | 2016-03-01 | 株式会社Ihi | 金属サレン錯体化合物、局所麻酔薬剤及び抗悪性腫瘍薬剤 |
| SG10201610416TA (en) | 2012-06-13 | 2017-01-27 | Incyte Corp | Substituted tricyclic compounds as fgfr inhibitors |
| BR112015000653A2 (pt) | 2012-07-11 | 2019-11-05 | Blueprint Medicines Corp | compostos inibidores do receptor de fator de crescimento de fibroblasto, sua composição farmacêutica e seus usos |
| WO2014026125A1 (en) | 2012-08-10 | 2014-02-13 | Incyte Corporation | Pyrazine derivatives as fgfr inhibitors |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| AR094812A1 (es) | 2013-02-20 | 2015-08-26 | Eisai R&D Man Co Ltd | Derivado de piridina monocíclico como inhibidor del fgfr |
| HUE036571T2 (hu) | 2013-04-19 | 2018-07-30 | Incyte Holdings Corp | Biciklusos heterociklusok mint FGFR inhibitorok |
| EP3023101B1 (en) * | 2013-07-18 | 2020-08-19 | Taiho Pharmaceutical Co., Ltd. | Therapeutic agent for fgfr inhibitor-resistant cancer |
| PL3023100T3 (pl) * | 2013-07-18 | 2019-07-31 | Taiho Pharmaceutical Co., Ltd. | Lek przeciwnowotworowy do okresowego podawania inhibitora FGFR |
| DK2947086T3 (en) * | 2013-08-12 | 2018-03-19 | Taiho Pharmaceutical Co Ltd | UNKNOWN CONDENSED PYRIMIDINE COMPOUND OR SALT THEREOF |
| AU2014339972B9 (en) | 2013-10-25 | 2019-05-30 | Blueprint Medicines Corporation | Inhibitors of the fibroblast growth factor receptor |
| WO2015099127A1 (ja) * | 2013-12-27 | 2015-07-02 | 中外製薬株式会社 | Ｆｇｆｒゲートキーパー変異遺伝子およびそれを標的とする医薬 |
| WO2015108992A1 (en) | 2014-01-15 | 2015-07-23 | Blueprint Medicines Corporation | Heterobicyclic compounds and their use as fgfr4 receptor inhibitors |
| PT3103802T (pt) * | 2014-06-24 | 2017-12-11 | Taiho Pharmaceutical Co Ltd | Novo composto de pirrolopirimidina ou seu sal, composição farmacêutica que o contém, especialmente agente para prevenção e/ou tratamento de tumores etc. com base no efeito inibidor de nae |
| US9951047B2 (en) | 2014-08-18 | 2018-04-24 | Eisai R&D Management Co., Ltd. | Salt of monocyclic pyridine derivative and crystal thereof |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| CN105837575B (zh) * | 2015-01-13 | 2019-01-15 | 四川大学 | 3-乙炔基吡唑并嘧啶衍生物及其制备方法和用途 |
| JP6093485B2 (ja) * | 2015-01-30 | 2017-03-08 | 大鵬薬品工業株式会社 | 免疫疾患の予防及び／又は治療剤 |
| EP3259269B9 (en) | 2015-02-20 | 2020-03-04 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| US9580423B2 (en) | 2015-02-20 | 2017-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| PT3279202T (pt) * | 2015-03-31 | 2020-08-31 | Taiho Pharmaceutical Co Ltd | Cristal de composto de alquinilo de benzeno 3,5-dissubstituído |
| US10479780B2 (en) | 2015-06-17 | 2019-11-19 | Chugai Seiyaku Kabushiki Kaisha | Aminopyrazole derivatives |
| WO2017038838A1 (ja) * | 2015-09-01 | 2017-03-09 | 大鵬薬品工業株式会社 | 新規なピラゾロ［３，４－ｄ］ピリミジン化合物又はその塩 |
| TWI623316B (zh) * | 2015-12-22 | 2018-05-11 | Taiho Pharmaceutical Co Ltd | Antitumor effect enhancer derived from pyrrolopyrimidine compound |
| TWI687422B (zh) * | 2016-02-23 | 2020-03-11 | 日商大鵬藥品工業股份有限公司 | 新穎稠合嘧啶化合物或其鹽 |
| WO2017150725A1 (ja) * | 2016-03-04 | 2017-09-08 | 大鵬薬品工業株式会社 | 悪性腫瘍治療用製剤及び組成物 |
| US11883404B2 (en) | 2016-03-04 | 2024-01-30 | Taiho Pharmaceuticals Co., Ltd. | Preparation and composition for treatment of malignant tumors |
| CN107344940B (zh) * | 2016-05-06 | 2020-04-21 | 广东东阳光药业有限公司 | Btk抑制剂及其用途 |
| CN107698593A (zh) * | 2016-08-09 | 2018-02-16 | 南京天印健华医药科技有限公司 | 作为fgfr抑制剂的杂环化合物 |
| JP7223684B2 (ja) * | 2017-02-28 | 2023-02-16 | 大鵬薬品工業株式会社 | ピラゾロ［３，４－ｄ］ピリミジン化合物を用いた抗腫瘍効果増強剤 |
| AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
| KR20190043437A (ko) | 2017-10-18 | 2019-04-26 | 씨제이헬스케어 주식회사 | 단백질 키나제 억제제로서의 헤테로고리 화합물 |
| CN109776544B (zh) * | 2017-11-15 | 2022-02-01 | 上海医药工业研究院 | 吡唑并[3,4-d]嘧啶类化合物及其制备方法和用途 |
| FI3769765T3 (fi) | 2018-03-19 | 2024-05-15 | Taiho Pharmaceutical Co Ltd | Natriumalkyylisulfaattia sisältävä farmaseuttinen koostumus |
| KR20200135945A (ko) | 2018-03-28 | 2020-12-04 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 간세포 암종 치료제 |
| MX2020011639A (es) | 2018-05-04 | 2021-02-15 | Incyte Corp | Sales de un inhibidor de receptores de factor de crecimiento de fibroblastos (fgfr). |
| JP2021523121A (ja) | 2018-05-04 | 2021-09-02 | インサイト・コーポレイションＩｎｃｙｔｅ Ｃｏｒｐｏｒａｔｉｏｎ | Ｆｇｆｒ阻害剤の固体形態及びその調製プロセス |
| US11840535B2 (en) | 2018-07-02 | 2023-12-12 | Shenzhen Targetrx, Inc. | Alkynyl(hetero)aromatic compound for inhibiting protein kinase activity |
| JP7161546B2 (ja) * | 2018-11-09 | 2022-10-26 | 大鵬薬品工業株式会社 | ジメトキシベンゼン化合物の類縁物質、該化合物の分析方法及び標準品 |
| KR20210088651A (ko) | 2018-11-09 | 2021-07-14 | 다이호야쿠힌고교 가부시키가이샤 | 디메톡시벤젠 화합물의 제조 방법 |
| AU2019387843B2 (en) * | 2018-11-26 | 2023-03-16 | Taiho Pharmaceutical Co., Ltd. | Therapeutic and prophylactic method for tumor treatable with endocrine therapy by combined use of fibroblast growth factor receptor inhibitor with endocrine therapy |
| WO2020170355A1 (ja) * | 2019-02-20 | 2020-08-27 | 大鵬薬品工業株式会社 | Ｆｇｆｒ１変異腫瘍の治療方法 |
| JPWO2020175704A1 (pt) * | 2019-02-28 | 2020-09-03 | ||
| US11628162B2 (en) | 2019-03-08 | 2023-04-18 | Incyte Corporation | Methods of treating cancer with an FGFR inhibitor |
| AU2020242287A1 (en) | 2019-03-21 | 2021-09-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A Dbait molecule in combination with kinase inhibitor for the treatment of cancer |
| JP7527309B2 (ja) * | 2019-05-13 | 2024-08-02 | リレー セラピューティクス， インコーポレイテッド | Ｆｇｆｒ阻害剤およびそれらの使用 |
| CN114127051A (zh) * | 2019-05-17 | 2022-03-01 | 金耐特生物制药公司 | 成纤维细胞生长因子受体激酶的抑制剂 |
| KR20220024821A (ko) | 2019-06-21 | 2022-03-03 | 다이호야쿠힌고교 가부시키가이샤 | 악성 종양의 치료 방법 |
| US11591329B2 (en) | 2019-07-09 | 2023-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| WO2021067374A1 (en) | 2019-10-01 | 2021-04-08 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| PE20221085A1 (es) | 2019-10-14 | 2022-07-05 | Incyte Corp | Heterociclos biciclicos como inhibidores de fgfr |
| WO2021076728A1 (en) | 2019-10-16 | 2021-04-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| CN114761006A (zh) | 2019-11-08 | 2022-07-15 | Inserm(法国国家健康医学研究院) | 对激酶抑制剂产生耐药性的癌症的治疗方法 |
| CN114641293B (zh) * | 2019-11-08 | 2024-05-31 | 石药集团中奇制药技术（石家庄）有限公司 | 一种fgfr抑制剂的用途 |
| PE20221504A1 (es) | 2019-12-04 | 2022-09-30 | Incyte Corp | Derivados de un inhibidor de fgfr |
| US11897891B2 (en) | 2019-12-04 | 2024-02-13 | Incyte Corporation | Tricyclic heterocycles as FGFR inhibitors |
| WO2021146424A1 (en) | 2020-01-15 | 2021-07-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| JPWO2021153703A1 (pt) | 2020-01-31 | 2021-08-05 | ||
| AU2021308045B2 (en) * | 2020-07-15 | 2024-06-20 | Taiho Pharmaceutical Co., Ltd. | Pyrimidine compound-containing combination to be used in tumor treatment |
| TWI797711B (zh) * | 2020-08-13 | 2023-04-01 | 大陸商上海和譽生物醫藥科技有限公司 | 一種fgfr及其突變抑制劑，其製備方法和應用 |
| CN115867547A (zh) * | 2020-08-27 | 2023-03-28 | 上海和誉生物医药科技有限公司 | 一种1h-吡唑-4-酰胺衍生物，其制备方法和应用 |
| TW202233625A (zh) * | 2020-11-18 | 2022-09-01 | 美商傳達治療有限公司 | Ｆｇｆｒ抑制劑及其製造及使用方法 |
| CN114805359B (zh) * | 2021-01-28 | 2023-10-27 | 药雅科技(上海)有限公司 | 炔代杂环化合物fgfr抑制剂的制备方法和用途 |
| CN115028634B (zh) * | 2021-03-08 | 2023-11-28 | 药雅科技(上海)有限公司 | 一种炔代吡嗪并杂环类fgfr抑制剂及其制备方法和用途 |
| US12065494B2 (en) | 2021-04-12 | 2024-08-20 | Incyte Corporation | Combination therapy comprising an FGFR inhibitor and a Nectin-4 targeting agent |
| JP2024522189A (ja) | 2021-06-09 | 2024-06-11 | インサイト・コーポレイション | Ｆｇｆｒ阻害剤としての三環式ヘテロ環 |
| CN115785103A (zh) * | 2022-12-28 | 2023-03-14 | 北京康立生医药技术开发有限公司 | 一种治疗胆管癌药物福巴替尼的合成方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200738725A (en) * | 2006-01-25 | 2007-10-16 | Osi Pharm Inc | Unsaturated mTOR inhibitors |
| ES2562215T3 (es) * | 2007-03-28 | 2016-03-03 | Pharmacyclics Llc | Inhibidores de la tirosina quinasa de Bruton |
| GB0819105D0 (en) * | 2008-10-17 | 2008-11-26 | Chroma Therapeutics Ltd | Pyrrolo-pyrimidine compounds |
| KR101483215B1 (ko) * | 2010-01-29 | 2015-01-16 | 한미약품 주식회사 | 단백질 키나아제 저해활성을 갖는 비시클릭 헤테로아릴 유도체 |
| WO2011153514A2 (en) | 2010-06-03 | 2011-12-08 | Pharmacyclics, Inc. | The use of inhibitors of bruton's tyrosine kinase (btk) |
-
2013
- 2013-01-17 PT PT137289187T patent/PT2657233E/pt unknown
- 2013-01-17 JP JP2013523428A patent/JP5355825B1/ja active Active
- 2013-01-17 MY MYPI2014700531A patent/MY171055A/en unknown
- 2013-01-17 DK DK13728918.7T patent/DK2657233T3/da active
- 2013-01-17 WO PCT/JP2013/050740 patent/WO2013108809A1/ja active Application Filing
- 2013-01-17 CA CA2854093A patent/CA2854093C/en active Active
- 2013-01-17 SG SG2014009286A patent/SG2014009286A/en unknown
- 2013-01-17 US US14/344,935 patent/US9108973B2/en active Active
- 2013-01-17 EP EP13728918.7A patent/EP2657233B1/en active Active
- 2013-01-17 RU RU2014133907/04A patent/RU2576384C1/ru active
- 2013-01-17 PL PL13728918T patent/PL2657233T3/pl unknown
- 2013-01-17 BR BR112014017749-0A patent/BR112014017749B1/pt active IP Right Grant
- 2013-01-17 ES ES13728918.7T patent/ES2516392T3/es active Active
- 2013-01-17 MX MX2014008605A patent/MX351513B/es active IP Right Grant
- 2013-01-17 CN CN201380003870.8A patent/CN103958512B/zh active Active
- 2013-01-17 AU AU2013210403A patent/AU2013210403B2/en active Active
- 2013-01-17 KR KR1020147013608A patent/KR101623286B1/ko active IP Right Grant
- 2013-01-18 TW TW102102005A patent/TWI508964B/zh active
-
2014
- 2014-11-18 HK HK14111639.8A patent/HK1198164A1/zh unknown
-
2023
- 2023-12-18 NL NL301254C patent/NL301254I2/nl unknown
- 2023-12-18 FI FIC20230038C patent/FIC20230038I1/fi unknown
- 2023-12-19 FR FR23C1050C patent/FR23C1050I1/fr active Active
- 2023-12-20 NO NO2023046C patent/NO2023046I1/no unknown
- 2023-12-21 HU HUS2300043C patent/HUS2300043I1/hu unknown
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