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PT2317317E - Ligandos a proteína de prião e métodos de uso - Google Patents

Ligandos a proteína de prião e métodos de uso Download PDF

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Publication number
PT2317317E
PT2317317E PT10176707T PT10176707T PT2317317E PT 2317317 E PT2317317 E PT 2317317E PT 10176707 T PT10176707 T PT 10176707T PT 10176707 T PT10176707 T PT 10176707T PT 2317317 E PT2317317 E PT 2317317E
Authority
PT
Portugal
Prior art keywords
prion protein
ligands
prion
methods
protein ligands
Prior art date
Application number
PT10176707T
Other languages
English (en)
Original Assignee
Univ North Carolina State
Pathogen Removal & Diagnostic Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ North Carolina State, Pathogen Removal & Diagnostic Technologies Inc filed Critical Univ North Carolina State
Publication of PT2317317E publication Critical patent/PT2317317E/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/081—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0819—Tripeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2828—Prion diseases

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PT10176707T 2002-12-03 2003-12-03 Ligandos a proteína de prião e métodos de uso PT2317317E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US43042302P 2002-12-03 2002-12-03

Publications (1)

Publication Number Publication Date
PT2317317E true PT2317317E (pt) 2015-03-02

Family

ID=32469468

Family Applications (4)

Application Number Title Priority Date Filing Date
PT101767085T PT2312318E (pt) 2002-12-03 2003-12-03 Ligandos a proteína de prião e métodos de uso
PT03808431T PT1573323E (pt) 2002-12-03 2003-12-03 Ligandos a proteína de prião e métodos de uso
PT08150151T PT1953551E (pt) 2002-12-03 2003-12-03 Ligandos a proteína de prião e métodos de uso
PT10176707T PT2317317E (pt) 2002-12-03 2003-12-03 Ligandos a proteína de prião e métodos de uso

Family Applications Before (3)

Application Number Title Priority Date Filing Date
PT101767085T PT2312318E (pt) 2002-12-03 2003-12-03 Ligandos a proteína de prião e métodos de uso
PT03808431T PT1573323E (pt) 2002-12-03 2003-12-03 Ligandos a proteína de prião e métodos de uso
PT08150151T PT1953551E (pt) 2002-12-03 2003-12-03 Ligandos a proteína de prião e métodos de uso

Country Status (15)

Country Link
US (3) US7863411B2 (pt)
EP (4) EP1953551B1 (pt)
JP (1) JP4485367B2 (pt)
CN (3) CN102241741B (pt)
AT (1) ATE529744T1 (pt)
AU (2) AU2003302500B2 (pt)
CA (2) CA2507936C (pt)
DK (4) DK2312318T3 (pt)
ES (4) ES2527408T3 (pt)
HK (4) HK1088948A1 (pt)
IL (3) IL168904A (pt)
MX (2) MXPA05005920A (pt)
NZ (3) NZ540417A (pt)
PT (4) PT2312318E (pt)
WO (1) WO2004050851A2 (pt)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050026165A1 (en) 2001-05-31 2005-02-03 Cindy Orser Detection of conformationally altered proteins and prions
AU2002320045B2 (en) * 2001-05-31 2008-05-08 Adlyfe, Inc. Misfolded protein sensor method
ES2527408T3 (es) * 2002-12-03 2015-01-23 North Carolina State University Ligandos de proteínas priones y procedimientos de uso
JP2006524340A (ja) * 2003-04-14 2006-10-26 アメリカン ナショナル レッド クロス タンパク質の構造アイソフォームに特異的なリガンドを特定するための方法
BRPI0413495A (pt) 2003-08-13 2006-10-17 Chiron Corp reagentes de peptìdeos especìficos para prìons e seus usos
US20060035242A1 (en) * 2004-08-13 2006-02-16 Michelitsch Melissa D Prion-specific peptide reagents
US20060057671A1 (en) * 2004-09-10 2006-03-16 Orser Cindy S Immobilized probes and methods of detecting conformationally altered prion proteins
CN101156068B (zh) * 2005-02-15 2015-03-18 阿德利夫股份有限公司 检测错折叠蛋白和朊病毒的方法
EP2383281A3 (en) * 2005-09-09 2012-01-04 Novartis AG Prion-specific peptoid reagents
US8168181B2 (en) 2006-02-13 2012-05-01 Alethia Biotherapeutics, Inc. Methods of impairing osteoclast differentiation using antibodies that bind siglec-15
US7989160B2 (en) 2006-02-13 2011-08-02 Alethia Biotherapeutics Inc. Polynucleotides and polypeptide sequences involved in the process of bone remodeling
WO2008005960A2 (en) * 2006-07-07 2008-01-10 Pall Corporation Prion processing
CA2657503C (en) * 2006-07-28 2014-10-21 Adlyfe, Inc. Peptide probes for diagnostics and therapeutics
JP2010515879A (ja) * 2007-01-12 2010-05-13 オールプリオン・アーゲー プリオンタンパク質を取り出すための方法
CA2721982A1 (en) * 2008-04-30 2009-11-05 Novartis Ag Assay for pathogenic conformers
MY175260A (en) * 2009-04-15 2020-06-17 Abraxis Bioscience Llc Prion free nanoparticle compositions and methods of making thereof
JP5862560B2 (ja) 2009-05-21 2016-02-16 アメリカン ナショナル レッド クロス レセプター随伴タンパク質（ｒａｐ）、前記の誘導体、模倣体および合成ペプチドによるプリオン増殖の阻害
US8841429B2 (en) * 2009-11-03 2014-09-23 Vivonics, Inc. Nucleic acid ligands against infectious prions
AU2010315133B2 (en) * 2009-11-04 2015-09-10 Novartis Ag Positively charged species as binding reagents in the separation of protein aggregates from monomers
US9162223B2 (en) 2011-12-21 2015-10-20 North Carolina State University Alkaline-stable chromatographic resins
CN104507969A (zh) 2012-07-19 2015-04-08 阿莱斯亚生物疗法股份有限公司 抗siglec-15抗体
CN103336124B (zh) * 2012-12-11 2015-07-15 武汉工业学院 一种检测朊病毒蛋白(PrPSC)的方法和试剂盒
EP2995621A1 (en) 2014-09-10 2016-03-16 Previpharma AG Ligands and methods for isolating or removing proteins
KR20190057444A (ko) 2015-08-10 2019-05-28 에센릭스 코프. 단계 간단화, 소량 샘플, 속도 가속화, 사용이 용이한 생물화학 측정장치 및 방법
KR101982331B1 (ko) 2015-09-14 2019-05-24 에센릭스 코프. 샘플 특히 혈액샘플을 분석하기 위한 장치와 시스템 및 그 사용 방법
IL258100B2 (en) 2015-09-14 2023-04-01 Essenlix Corp Apparatus and system for collecting and analyzing condensed vapor, especially condensed exhalation, and methods for using the same
WO2018119318A1 (en) 2016-12-21 2018-06-28 Essenlix Corporation Devices and methods for authenticating a sample and use of the same
JP7003158B2 (ja) 2017-02-07 2022-01-20 エッセンリックス コーポレーション 圧縮開放流アッセイおよび使用
CA3052809A1 (en) 2017-02-08 2018-08-23 Essenlix Corporation Qmax assays and applications
US10823645B2 (en) 2017-02-08 2020-11-03 Essenlix Corporation Sample collection and handling for delayed analysis
CN111316096B (zh) 2017-02-08 2023-08-11 Essenlix公司 生物/化学材料提取和测定
WO2018148609A2 (en) 2017-02-09 2018-08-16 Essenlix Corporation Colorimetric assays
CN110998325B (zh) 2017-02-09 2024-08-16 上海宜晟生物科技有限公司 扩增测定
US11883824B2 (en) 2017-02-09 2024-01-30 Essenlix Corporation Assay using different spacing heights
CA3053301A1 (en) 2017-02-16 2018-08-23 Essenlix Corporation Assay with textured surface
EP3406632A1 (en) 2017-05-23 2018-11-28 S.I.S.S.A. Scuola Internazionale Superiore di Studi Avanzati Ligands binding to prion protein for use in the treatment of synucleinopathies
CN112689758A (zh) 2017-08-01 2021-04-20 Essenlix公司 检查药物对微生物影响的装置和方法
US11280706B2 (en) 2017-08-01 2022-03-22 Essenlix Corporation Dilution calibration
US11243201B2 (en) 2017-08-01 2022-02-08 Essenlix Corporation Sample collection, holding and assaying
US11393561B2 (en) 2017-10-13 2022-07-19 Essenlix Corporation Devices and methods for authenticating a medical test and use of the same
US10807095B2 (en) 2017-10-26 2020-10-20 Essenlix Corporation Making and tracking assay card
US11237113B2 (en) 2017-10-26 2022-02-01 Essenlix Corporation Rapid pH measurement
US11609224B2 (en) 2017-10-26 2023-03-21 Essenlix Corporation Devices and methods for white blood cell analyses
WO2019118652A1 (en) 2017-12-12 2019-06-20 Essenlix Corporation Sample manipulation and assay with rapid temperature change
CN112534259A (zh) 2017-12-14 2021-03-19 Essenlix公司 监测毛发的装置，系统和方法
US11156606B2 (en) 2018-01-11 2021-10-26 Essenlix Corporation Homogeneous assay (II)
US11885952B2 (en) 2018-07-30 2024-01-30 Essenlix Corporation Optics, device, and system for assaying and imaging
JP7376040B2 (ja) * 2019-09-03 2023-11-08 国立大学法人京都工芸繊維大学 神経変性疾患におけるバイオマーカー分子の検出方法
CN115838395A (zh) * 2022-11-15 2023-03-24 西北农林科技大学 具有可溶性环氧化物水解酶抑制作用的活性肽及其应用

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3601398A1 (de) * 1986-01-18 1987-07-23 Fresenius Ag Verwendung von oligopeptiden zur behandlung von cerebralen stoerungen
US5133866A (en) * 1988-03-24 1992-07-28 Terrapin Technologies, Inc. Method to identify analyte-bending ligands
US5010175A (en) * 1988-05-02 1991-04-23 The Regents Of The University Of California General method for producing and selecting peptides with specific properties
EP0347890B1 (en) * 1988-06-22 1993-03-17 Roussel Morishita Co., Ltd. Amino acid nutrient compositions
AU6753390A (en) * 1989-10-02 1991-04-28 University Of Michigan, The Bioanalytical detection system
US5498538A (en) * 1990-02-15 1996-03-12 The University Of North Carolina At Chapel Hill Totally synthetic affinity reagents
WO1991013904A1 (en) 1990-03-05 1991-09-19 Cephalon, Inc. Chymotrypsin-like proteases and their inhibitors
US5416013A (en) * 1990-04-04 1995-05-16 Sterling Winthrop Inc. Interleukin 1β protease and interleukin 1β protease inhibitors
US6995141B1 (en) * 1990-04-04 2006-02-07 Vertex Pharmaceuticals Incorporated Interleukin 1β protease and interleukin 1β protease inhibitors
US5650489A (en) 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
GB9024005D0 (en) * 1990-11-05 1990-12-19 British Bio Technology Process for amplifying nucleic acid
DK0616613T3 (da) * 1991-12-03 1999-09-27 Proteus Molecular Design Fragmenter af prionprotein
US5312730A (en) * 1992-05-27 1994-05-17 Ciba Corning Diagnostics Corp. Immune complex transfer with lypophilic bridge
CA2109646C (en) * 1992-11-24 2000-03-07 Gaston O. Daumy Para-nitroanilide peptides
JPH08178926A (ja) * 1994-10-25 1996-07-12 Sumitomo Pharmaceut Co Ltd イムノアッセイプレートおよびその用途
US5834318A (en) 1995-05-10 1998-11-10 Bayer Corporation Screening of combinatorial peptide libraries for selection of peptide ligand useful in affinity purification of target proteins
US5948763A (en) * 1995-06-07 1999-09-07 New York University Peptides and pharmaceutical compositions thereof for treatment of disorders or diseases associated with abnormal protein folding into amyloid or amyloid-like deposits
US5958684A (en) * 1995-10-02 1999-09-28 Van Leeuwen; Frederik Willem Diagnosis of neurodegenerative disease
US5750361A (en) 1995-11-02 1998-05-12 The Regents Of The University Of California Formation and use of prion protein (PRP) complexes
ATE249046T1 (de) * 1996-05-14 2003-09-15 Winnacker Ernst Ludwig Prof Chaperone, die prionproteine binden und zwischen den isoformen prpc und prpsc unterscheiden können
BR9709900A (pt) * 1996-05-29 2000-01-25 Univ Mcgill Proteìnas de ligacão de proteìnas de prìons e usos das mesmas.
US5808011A (en) 1996-07-01 1998-09-15 Biopure Corporation Method for chromatographic removal of prions
US6126939A (en) * 1996-09-03 2000-10-03 Yeda Research And Development Co. Ltd. Anti-inflammatory dipeptide and pharmaceutical composition thereof
JPH10182695A (ja) * 1996-12-27 1998-07-07 Teikoku Seiyaku Co Ltd ｇｐ１２０に対して親和性を有するペプチド
US6221614B1 (en) * 1997-02-21 2001-04-24 The Regents Of The University Of California Removal of prions from blood, plasma and other liquids
GB9710582D0 (en) * 1997-05-22 1997-07-16 Oxford Glycosciences Uk Ltd A method for de novo peptide sequence determination
US6211149B1 (en) * 1998-08-03 2001-04-03 The United States Of America As Represented By The Department Of Health And Human Services Inhibitors of formation of protease resistant prion protein
US6750025B1 (en) * 1998-07-09 2004-06-15 V.I. Technologies, Inc. Method of detecting and isolating prion protein and variants thereof
DE19917838A1 (de) * 1999-01-12 2000-07-13 Bundesrepublik Deutschland Let Arzneimittel zur prophylaktischen oder therapeutischen Behandlung von transmissiblen spongiformen Enzephalopathien, Morbus Alzheimer und Corea Huntington und anderen neurodegenerativen Erkrankungen sowie diagnostische Mittel
DE10027695A1 (de) * 1999-05-27 2001-04-19 Max Delbrueck Centrum Vakzine gegen konformationsabhängige Antigene sowie gegen Antigene, die keine oder nicht ausschließlich Proteine oder Peptide sind
MXPA01013186A (es) * 1999-06-23 2002-08-12 Caprion Pharmaceuticals Inc Peptidos de la proteina prion y sus usos.
CA2376914A1 (en) * 1999-06-29 2001-01-04 Mcgill University Prion protein binding proteins and uses thereof
US6261790B1 (en) * 1999-07-15 2001-07-17 The United States Of America As Represented By The Secretary Of Agriculture Monoclonal antibodies and antibody cocktail for detection of prion protein as an indication of transmissible spongiform encephalopathies
WO2001006989A2 (en) * 1999-07-27 2001-02-01 Abgenix, Inc. Methods and compositions for inhibiting polypeptide accumulation associated with neurological disorders
WO2001019867A1 (de) * 1999-09-14 2001-03-22 Memorec Stoffel Gmbh Prionen-verwandtes protein
US6437102B1 (en) * 1999-11-24 2002-08-20 Bayer Corporation Method of separating prions from biological materials
WO2001071042A2 (en) * 2000-03-23 2001-09-27 Pe Corporation (Ny) Detection kits, such as nucleic acid arrays, for detecting the expression of 10,000 or more drosophila genes and uses thereof
WO2001077687A2 (en) * 2000-04-05 2001-10-18 V.I Technologies, Inc. Prion-binding peptidic ligands and methods of using same
WO2001078344A1 (fr) * 2000-04-12 2001-10-18 Sony Corporation Procede et appareil de transmission de donnees
GB0009918D0 (en) * 2000-04-20 2000-06-07 Rose Keith Covalent capture facilitating purification of polypeptides
US20020155106A1 (en) * 2000-12-01 2002-10-24 Hammond David J. Method of identifying a ligand for a target molecule
WO2003016904A2 (en) 2001-08-13 2003-02-27 Campbell Douglas A Peptide sequence tags and method of using same
DE10152677A1 (de) * 2001-10-19 2003-05-08 Aventis Behring Gmbh Antikörper zum spezifischen Nachweis von pathogenen Prionen humanen Ursprungs und damit durchgeführten Nachweisverfahren
JP2003149461A (ja) * 2001-11-12 2003-05-21 Allied Tereshisu Kk 収納装置
ES2527408T3 (es) * 2002-12-03 2015-01-23 North Carolina State University Ligandos de proteínas priones y procedimientos de uso
ES2436638T3 (es) * 2003-04-04 2014-01-03 Pathogen Removal And Diagnostic Technologies, Inc. Materiales de unión de proteínas del prión y métodos de uso
US7510848B2 (en) * 2003-04-04 2009-03-31 North Carolina State University Prion protein binding materials and methods of use
WO2006102099A2 (en) 2005-03-18 2006-09-28 The Regents Of The University Of California ANTIBODIES SPECIFIC FOR HUMAN AND BOVINE PrP

Also Published As

Publication number Publication date
AU2003302500A1 (en) 2004-06-23
EP2317317A1 (en) 2011-05-04
CN102241741A (zh) 2011-11-16
DK2317317T3 (en) 2015-03-02
IL206129A0 (en) 2010-11-30
AU2010201499B2 (en) 2013-02-07
ATE529744T1 (de) 2011-11-15
CA2836951A1 (en) 2004-06-17
CN102241741B (zh) 2013-11-13
MX337569B (es) 2016-03-09
JP2006509013A (ja) 2006-03-16
CA2836951C (en) 2017-01-10
WO2004050851A3 (en) 2005-01-27
US20040229280A1 (en) 2004-11-18
WO2004050851A2 (en) 2004-06-17
CA2507936A1 (en) 2004-06-17
EP1573323A2 (en) 2005-09-14
HK1157010A1 (en) 2012-06-22
IL200468A0 (en) 2011-07-31
EP2317317B1 (en) 2014-11-26
PT1953551E (pt) 2014-05-06
DK1953551T3 (da) 2014-05-12
CN102297798B (zh) 2015-11-18
EP1953551B1 (en) 2014-02-19
AU2003302500B2 (en) 2010-04-29
CA2507936C (en) 2014-02-25
CN1739029A (zh) 2006-02-22
MXPA05005920A (es) 2006-03-17
ES2531926T3 (es) 2015-03-20
EP2312318A1 (en) 2011-04-20
ES2375958T3 (es) 2012-03-07
CN1739029B (zh) 2011-06-22
NZ560410A (en) 2008-12-24
CN102297798A (zh) 2011-12-28
DK1573323T3 (da) 2012-01-23
EP2312318B1 (en) 2014-10-08
HK1124388A1 (en) 2009-07-10
ES2460641T3 (es) 2014-05-14
IL200468A (en) 2012-06-28
AU2010201499A1 (en) 2010-05-06
NZ540417A (en) 2008-04-30
PT1573323E (pt) 2012-01-10
HK1157009A1 (en) 2012-06-22
US20080268474A1 (en) 2008-10-30
US8604161B2 (en) 2013-12-10
PT2312318E (pt) 2015-01-14
EP1573323B1 (en) 2011-10-19
EP1573323A4 (en) 2007-04-04
EP1953551A2 (en) 2008-08-06
US9678085B2 (en) 2017-06-13
US20140206021A1 (en) 2014-07-24
IL206129A (en) 2013-11-28
US7863411B2 (en) 2011-01-04
IL168904A (en) 2010-11-30
JP4485367B2 (ja) 2010-06-23
NZ572892A (en) 2010-03-26
HK1088948A1 (en) 2006-11-17
EP1953551A3 (en) 2009-03-18
ES2527408T3 (es) 2015-01-23
DK2312318T3 (en) 2015-01-12

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