PT1037909E - Síndrome multi-sistémica do definhamento pós-desmame de porcos - Google Patents
Síndrome multi-sistémica do definhamento pós-desmame de porcos Download PDFInfo
- Publication number
- PT1037909E PT1037909E PT98959682T PT98959682T PT1037909E PT 1037909 E PT1037909 E PT 1037909E PT 98959682 T PT98959682 T PT 98959682T PT 98959682 T PT98959682 T PT 98959682T PT 1037909 E PT1037909 E PT 1037909E
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- Prior art keywords
- kit
- pcvii
- polynucleotide
- sequence
- quot
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- 241000282887 Suidae Species 0.000 title 1
- 241000700605 Viruses Species 0.000 title 1
- 208000028489 postweaning multisystemic wasting syndrome Diseases 0.000 title 1
- 108091033319 polynucleotide Proteins 0.000 claims abstract 14
- 239000002157 polynucleotide Substances 0.000 claims abstract 14
- 102000040430 polynucleotide Human genes 0.000 claims abstract 14
- 239000000523 sample Substances 0.000 claims abstract 10
- 208000015181 infectious disease Diseases 0.000 claims abstract 3
- 241000251539 Vertebrata <Metazoa> Species 0.000 claims abstract 2
- 241001673669 Porcine circovirus 2 Species 0.000 claims 17
- 238000000034 method Methods 0.000 claims 14
- 239000002773 nucleotide Substances 0.000 claims 9
- 125000003729 nucleotide group Chemical group 0.000 claims 9
- 239000012634 fragment Substances 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 239000012472 biological sample Substances 0.000 claims 3
- 238000009396 hybridization Methods 0.000 claims 3
- 230000003321 amplification Effects 0.000 claims 2
- 238000003556 assay Methods 0.000 claims 2
- 230000000295 complement effect Effects 0.000 claims 2
- 238000001514 detection method Methods 0.000 claims 2
- 238000003199 nucleic acid amplification method Methods 0.000 claims 2
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 claims 1
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 claims 1
- 108020004711 Nucleic Acid Probes Proteins 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 238000004925 denaturation Methods 0.000 claims 1
- 230000036425 denaturation Effects 0.000 claims 1
- 239000005547 deoxyribonucleotide Substances 0.000 claims 1
- 125000002637 deoxyribonucleotide group Chemical group 0.000 claims 1
- 239000002853 nucleic acid probe Substances 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 230000003612 virological effect Effects 0.000 abstract 2
- 238000010367 cloning Methods 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/10011—Circoviridae
- C12N2750/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/10011—Circoviridae
- C12N2750/10041—Use of virus, viral particle or viral elements as a vector
- C12N2750/10043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plant Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Analytical Chemistry (AREA)
- Communicable Diseases (AREA)
- Mycology (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Claims (15)
- ΡΕ1037909 1 REIVINDICAÇÕES 1. Um método para a detecção de sequências homólogas de circovírus porcino Tipo II (PCVII) numa amostra biológica compreendendo: (a) incubação da amostra biológica com um polinucleótido capaz de hibridar selectivamente com uma sequência nucleotidica de PCVII, em que o polinucleótido compreende pelo menos 8 nucleótidos contíguos derivados ou complementares de uma sequência de PCVII descrita nas Figuras 2A-2C ou 4A-4B ou SEQ ID NO:1, 11, 12 ou 24, em condições que promovem a formação de complexos de ácidos nucleicos entre o polinucleótido e a sequência nucleotidica de PCVII presente na amostra biológica; e (b) detecção dos complexos contendo o polinucleótido.
- 2. O método da reivindicação 1 em que o referido polinucleótido é marcado e os complexos são detectados através da detecção da presença da marca.
- 3. O método da reivindicação 1, em que a referida detecção compreende a utilização de duas sondas especificas de ácido nucleico de PCVII, em que as duas sondas definem uma região interna do ácido nucleico de PCVII e cada uma das sondas possui uma cadeia contendo um extremo 3' interno relativamente à região, convertendo os complexos de hibridação ácido nucleico/sonda em fragmentos 2 ΡΕ1037909 de cadeia dupla contendo sonda através de reacções de extensão de sequências iniciadoras, amplificação do número de fragmentos contendo sonda através da repetição sucessiva dos passos de (i) desnaturação dos fragmentos de cadeia dupla para produzir fragmentos de cadeia simples, (ii) hibridação de cadeias simples com as sondas para formar complexos de cadeia/sonda, (iii) geração de fragmentos de cadeia dupla a partir dos complexos cadeia/sonda na presença de DNA polimerase e dos quatro desoxirribonucleótidos e (iv) repetição dos passos (i) a (ii) até ser atingido um grau pretendido de amplificação, identificação dos produtos de amplificação.
- 4. Um estojo ("kit") de testes para a detecção da infecção por PCVII num indivíduo vertebrado, o referido estojo ("kit") de testes compreendendo um polinucleótido capaz de hibridar selectivamente com uma sequência nucleotídica de PCVII, em que o polinucleótido compreende pelo menos 8 nucleótidos contíguos derivados ou complementares de uma sequência de PCVII descrita nas Figuras 2A-2C ou 4A-4B ou SEQ ID N0:1, 11, 12 ou 24, e instruções para a realização do teste.
- 5. O método de qualquer uma das reivindicações 1 a 3, ou o estojo ("kit") da reivindicação 4, em que o polinucleótido tem pelo menos 10 nucleótidos de comprimento . 3 ΡΕ1037909
- 6. O método de qualquer uma das reivindicações 1 a 3, ou o estojo ("kit") da reivindicação 4, em que o polinucleótido tem pelo menos 15 nucleótidos de comprimento.
- 7. 0 método de qualquer uma das reivindicações 1 a 3, ou o estojo ("kit") da reivindicação 4, em que o polinucleótido tem pelo menos 25 nucleótidos de comprimento .
- 8. 0 método de qualquer uma das reivindicações 1 a 3, ou o estojo ("kit") da reivindicação 4, em que o polinucleótido tem pelo menos 75 nucleótidos de comprimento .
- 9. O método de qualquer uma das reivindicações 1 a 3, ou o estojo ("kit") da reivindicação 4, em que a sequência de PCVII tem pelo menos 85% de identidade com uma sequência de PCVII descrita nas Figuras 2A-2C ou 4A-4B ou SEQ ID NO:1, 11, 12 ou 24.
- 10. O método de qualquer uma das reivindicações 1 a 3, ou o estojo ("kit") da reivindicação4, em que a sequência de PCVII tem pelo menos 90% de identidade com uma sequência de PCVII descrita nas Figuras 2A-2C ou 4A-4B ou SEQ ID NO:1, 11, 12 ou 24.
- 11. O método de qualquer uma das reivindicações 1 a 3, ou o estojo ("kit") da reivindicação4, em que a 4 ΡΕ1037909 sequência de PCVII tem pelo menos 95% de identidade com uma sequência de PCVII descrita nas Figuras 2A-2C ou 4A-4B ou SEQ ID NO:l, 11, 12 ou 24.
- 12. O método de qualquer uma das reivindicações 1 a 3, ou o estojo ("kit") da reivindicação4, em que a hibridação é realizada em condições de restringência.
- 13. O método de qualquer uma das reivindicações 1 a 3, ou o estojo ("kit") da reivindicação4, em que o polinucleótido tem a sequência CATACATGGTTACACGGATATTG.
- 14. O método de qualquer uma das reivindicações 1 a 3, ou o estojo ("kit") da reivindicação4, em que o polinucleótido tem a sequência CCGCACCTTCGGATATACTG.
- 15. O método de qualquer uma das reivindicações 1 a 3, ou o estojo ("kit") da reivindicação4, em que as sondas especificas do ácido nucleico de PCVII tem a sequência CATACATGGTTACACGGATATTG e CCGCACCTTCGGATATACTG. Lisboa, 28 de Agosto de 2007
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6923397P | 1997-12-11 | 1997-12-11 | |
| US6975097P | 1997-12-16 | 1997-12-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1037909E true PT1037909E (pt) | 2007-09-07 |
Family
ID=26749812
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT98959682T PT1037909E (pt) | 1997-12-11 | 1998-12-11 | Síndrome multi-sistémica do definhamento pós-desmame de porcos |
| PT100121961T PT2363488E (pt) | 1997-12-11 | 1998-12-11 | Síndrome multi-sistémica do definhamento pós-desmame de porcos |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT100121961T PT2363488E (pt) | 1997-12-11 | 1998-12-11 | Síndrome multi-sistémica do definhamento pós-desmame de porcos |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US20020106639A1 (pt) |
| EP (2) | EP1037909B1 (pt) |
| JP (5) | JP3795751B2 (pt) |
| KR (3) | KR100688008B1 (pt) |
| CN (1) | CN1309708A (pt) |
| AT (1) | ATE364624T1 (pt) |
| AU (1) | AU764379B2 (pt) |
| BR (1) | BR9813485A (pt) |
| CA (1) | CA2313806A1 (pt) |
| CY (1) | CY1107720T1 (pt) |
| DE (2) | DE69837934T2 (pt) |
| DK (2) | DK1037909T3 (pt) |
| ES (2) | ES2526760T3 (pt) |
| HK (1) | HK1102829A1 (pt) |
| ID (1) | ID28224A (pt) |
| NZ (1) | NZ505008A (pt) |
| PT (2) | PT1037909E (pt) |
| RU (1) | RU2000118777A (pt) |
| WO (1) | WO1999029717A2 (pt) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7211379B2 (en) | 1997-10-03 | 2007-05-01 | Merial Sas | Prevention of myocarditis, abortion and intrauterine infection associated with porcine circovirus-2 |
| US6517843B1 (en) | 1999-08-31 | 2003-02-11 | Merial | Reduction of porcine circovirus-2 viral load with inactivated PCV-2 |
| US7192594B2 (en) | 1997-10-03 | 2007-03-20 | Merial Limited | Postweaning multisystemic wasting syndrome and porcine circovirus from pigs |
| US6391314B1 (en) * | 1997-10-03 | 2002-05-21 | Merial | Porcine circoviruses vaccines diagnostic reagents |
| UA78180C2 (uk) * | 1997-10-03 | 2007-03-15 | Меріаль | Кільцевий вірус свині типу ii, вакцини та діагностичні реагенти |
| US20040062775A1 (en) * | 1997-12-05 | 2004-04-01 | Agence Francaise De Securite Sanitaire Des Aliments | Circovirus sequences associated with piglet weight loss disease (PWD) |
| FR2772047B1 (fr) * | 1997-12-05 | 2004-04-09 | Ct Nat D Etudes Veterinaires E | Sequence genomique et polypeptides de circovirus associe a la maladie de l'amaigrissement du porcelet (map), applications au diagnostic et a la prevention et/ou au traitement de l'infection |
| EP1816200B1 (en) | 1997-12-11 | 2016-03-09 | Merial | Postweaning multisystemic wasting syndrome virus for pigs |
| ID28224A (id) * | 1997-12-11 | 2001-05-10 | Univ Saskatchewan | Virus sindrom perusakan multisistemik paska-pemutusan dari babi |
| US6943152B1 (en) | 1999-06-10 | 2005-09-13 | Merial | DNA vaccine-PCV |
| ES2170622B1 (es) * | 1999-12-03 | 2004-05-16 | Consejo Superior De Investigaciones Cientificas | Clones y vectores infectivos derivados de coronavirus y sus aplicaciones. |
| AU2001266940A1 (en) * | 2000-06-15 | 2001-12-24 | Purdue Research Foundation | Vaccine for congenital tremors in pigs |
| US7276353B2 (en) * | 2001-12-12 | 2007-10-02 | Virginia Tech Intellectual Properties, Inc. | Chimeric infectious DNA clones, chimeric porcine circoviruses and uses thereof |
| RS51665B (en) | 2004-09-09 | 2011-10-31 | Novartis Vaccines And Diagnostics Gmbh. | Reduction of potential iatrogenic risks associated with influenza vaccines |
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| UA95602C2 (ru) | 2004-12-30 | 2011-08-25 | Берингер Ингельхейм Ветмедика, Инк. | Иммуногенная композиция цвс2 и способы приготовления такой композиции |
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| US8834891B2 (en) | 2005-03-14 | 2014-09-16 | Boehringer Ingelheim Vetmedica, Inc. | Immunogenic compositions comprising Lawsonia intracellularis |
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| TWI528970B (zh) | 2005-12-29 | 2016-04-11 | 百靈佳殷格翰家畜藥品公司 | 多價第二型豬環狀病毒（ｐｃｖ２）免疫組合物及製備該組合物之方法 |
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| WO2008073464A2 (en) | 2006-12-11 | 2008-06-19 | Boehringer Ingelheim Vetmedica, Inc. | Effective method of treatment of porcine circovirus and lawsonia intracellularis infections |
| AR064363A1 (es) | 2006-12-15 | 2009-04-01 | Boehringer Ingelheim Vetmed | Tratamiento de cerdos con el antigeno pcv |
| EP1941903A1 (en) | 2007-01-03 | 2008-07-09 | Boehringer Ingelheim Vetmedica Gmbh | Prophylaxis and treatment of PRDC |
| EP1958644A1 (en) | 2007-02-13 | 2008-08-20 | Boehringer Ingelheim Vetmedica Gmbh | Prevention and treatment of sub-clinical pcvd |
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| KR100983873B1 (ko) * | 2008-07-04 | 2010-10-01 | 대한민국 | 돼지 써코바이러스 타입 1 및 2의 감별진단을 위한미니어레이법 |
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- 1998-12-11 RU RU2000118777/13A patent/RU2000118777A/ru not_active Application Discontinuation
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- 1998-12-11 BR BR9813485-0A patent/BR9813485A/pt not_active Application Discontinuation
- 1998-12-11 DK DK10012196.1T patent/DK2363488T3/en active
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- 1998-12-11 CA CA002313806A patent/CA2313806A1/en not_active Abandoned
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