PE20171448A1 - Composiciones y metodos para activar la senalizacion dependiente del estimulador del gen de interferon - Google Patents
Composiciones y metodos para activar la senalizacion dependiente del estimulador del gen de interferonInfo
- Publication number
- PE20171448A1 PE20171448A1 PE2017001512A PE2017001512A PE20171448A1 PE 20171448 A1 PE20171448 A1 PE 20171448A1 PE 2017001512 A PE2017001512 A PE 2017001512A PE 2017001512 A PE2017001512 A PE 2017001512A PE 20171448 A1 PE20171448 A1 PE 20171448A1
- Authority
- PE
- Peru
- Prior art keywords
- interferon gene
- compositions
- methods
- compound
- gene stimulator
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/213—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se refiere a un compuesto de formula III, una sal, solvato o hidrato farmaceuticamente aceptable, donde R21 y R22 son guanina o adenina unida a la estructura a traves de la posicion N9, con la condicion de que R21 y R22 no sean ambos guanina. Es un compuesto preferido el 3´3´-RR-(2´F-G)(2´F-A);ditio-(Rp, Rp)-[2´F-G(3´,5´)p-2´F-A(3´,5´)p]-ciclico 2-amino-9-((2R,3R,3Ar; 5R, 7Ar, 9r, 10R, 10Ar,12R,14Ar)-9-(6-amino-9H-purin-9-il)-3,10-difluoro-5,12-dimercapto-5,12-dioxidooctahidro-2H,7H-difuro[3,2-d:3´,2´-j][1,3,7,9]tetraoxa[2,8]difosfaciclododedin-2-il)-1,9-dihidro-6H-purin-6-ona; entre otros. Tambien se refiere a una composicion farmaceutica que la comprende. Dicho compuesto es un estimulador inmunitario di-nucleotido-ciclico- (CDN) que activan DC a traves de un receptor citoplasmatico descubierto recientemente conocido como STING (Estimulador de genes de interferon) siendo util en el tratamiento de cancer, rechazo agudo de trasplante de organos, entre otros
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562131235P | 2015-03-10 | 2015-03-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20171448A1 true PE20171448A1 (es) | 2017-10-02 |
Family
ID=56879700
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2017001512A PE20171448A1 (es) | 2015-03-10 | 2016-03-09 | Composiciones y metodos para activar la senalizacion dependiente del estimulador del gen de interferon |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US10449211B2 (es) |
| EP (1) | EP3268035A4 (es) |
| JP (1) | JP6692826B2 (es) |
| KR (1) | KR20170129802A (es) |
| CN (1) | CN107530415A (es) |
| AR (1) | AR103894A1 (es) |
| AU (1) | AU2016229146A1 (es) |
| BR (1) | BR112017018908A2 (es) |
| CA (1) | CA2979215A1 (es) |
| CL (1) | CL2017002272A1 (es) |
| CO (1) | CO2017009104A2 (es) |
| CR (1) | CR20170410A (es) |
| DO (1) | DOP2017000205A (es) |
| EA (1) | EA035817B1 (es) |
| EC (1) | ECSP17064523A (es) |
| GT (1) | GT201700200A (es) |
| HK (2) | HK1247089A1 (es) |
| IL (1) | IL254047A0 (es) |
| JO (1) | JO3746B1 (es) |
| MA (1) | MA42146A (es) |
| MX (1) | MX2017011597A (es) |
| MY (1) | MY190404A (es) |
| PE (1) | PE20171448A1 (es) |
| PH (1) | PH12017501506A1 (es) |
| SG (1) | SG11201706756VA (es) |
| SV (1) | SV2017005529A (es) |
| TN (1) | TN2017000375A1 (es) |
| TW (1) | TWI706958B (es) |
| UY (1) | UY36579A (es) |
| WO (1) | WO2016145102A1 (es) |
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- 2016-03-09 EA EA201791999A patent/EA035817B1/ru unknown
- 2016-03-09 WO PCT/US2016/021597 patent/WO2016145102A1/en active Application Filing
- 2016-03-09 KR KR1020177028534A patent/KR20170129802A/ko not_active Application Discontinuation
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