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PE20121529A1 - Compuestos derivados de piridopirimidina como inhibidores de pde4 - Google Patents

Compuestos derivados de piridopirimidina como inhibidores de pde4

Info

Publication number
PE20121529A1
PE20121529A1 PE2012001093A PE2012001093A PE20121529A1 PE 20121529 A1 PE20121529 A1 PE 20121529A1 PE 2012001093 A PE2012001093 A PE 2012001093A PE 2012001093 A PE2012001093 A PE 2012001093A PE 20121529 A1 PE20121529 A1 PE 20121529A1
Authority
PE
Peru
Prior art keywords
pyridopyrimidine
optionally substituted
compounds derived
pde4 inhibitors
methyl
Prior art date
Application number
PE2012001093A
Other languages
English (en)
Inventor
Roger Victor Bonnert
Rhona Jane Cox
Sousa Simon De
Mark Dickinson
Simon Fraser Hunt
Premji Meghani
Austen Pimm
Histesh Jayantilal Sanganee
Frank Burkamp
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of PE20121529A1 publication Critical patent/PE20121529A1/es

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    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE PIRIDOPIRIMIDINA DE FORMULA (I) DONDE: A ES CA1; E ES CE1; W ES CH2; Y ES CH2; R1 ES FENILO SUSTITUIDO CON FENILO, O HETEROCICLILO OPCIONALMENTE SUSTITUIDO; R2 ES NHC(O)R3; R3 ES ALQUILO C1-4 SUSTITUIDO CON HETEROARILO ENTRE OTROS, CICLOALQUILO C3-7 OPCIONALMENTE SUSTITUIDO, O HETEROARILO OPCIONALMENTE SUSTITUIDO CON HALO, ENTRE OTROS; A1, E1 Y G1 SON INDEPENDIENTEMENTE H O HALOGENO. ES UN COMPUESTO PREFERIDO: N-{CIS-4-[1-(4'-{[(3R,5S)-3,5-DIMETILPIPERAZIN-1-IL]METIL}BIFENIL-3-IL)-6-FLUORO-2,4-DIOXO-1,4-DIHIDROPIRIDO[2,3-d]PIRIMIDIN-3(2H)-IL]CICLOHEXIL}-2-METIL-1,3-TIAZOL-4-CARBOXAMIDA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON INHIBIDORES DE PDE4 SIENDO UTIL EN EL TRATAMIENTO DE ASMA, BRONQUITIS, OSTEOPOROSIS, ARTRITIS, PSORIASIS
PE2012001093A 2007-01-11 2008-01-11 Compuestos derivados de piridopirimidina como inhibidores de pde4 PE20121529A1 (es)

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Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200726767A (en) * 2005-07-04 2007-07-16 Astrazeneca Ab Chemical compounds 2
US7858663B1 (en) * 2007-10-31 2010-12-28 Pisgah Laboratories, Inc. Physical and chemical properties of thyroid hormone organic acid addition salts
SA08280783B1 (ar) * 2007-01-11 2011-04-24 استرازينيكا ايه بي مشتقات بيريدوبيريميدين كمثبطات pde4
WO2010004319A1 (en) * 2008-07-07 2010-01-14 Astrazeneca Ab Combination comprising 6-flu0r0-n- ((1s, 4s) - 4- (6-fluoro-2, 4-di0x0-1- (4'- (piperazin-1- ylmethyl) biphenyl- 3-yl) -1, 2-dihydropyrido [2, 3-d] pyrimidin-3 (4h) - yl) cyclohexyl) imidazo [1,2-a] pyridine -2- carboxamide or a salt
TW201036957A (en) 2009-02-20 2010-10-16 Astrazeneca Ab Novel salt 628
JP5558875B2 (ja) * 2009-03-19 2014-07-23 日本曹達株式会社 新規包接錯体、エポキシ樹脂組成物及び半導体封止用エポキシ樹脂組成物
GB0913345D0 (en) 2009-07-31 2009-09-16 Astrazeneca Ab New combination 802
WO2011061527A1 (en) 2009-11-17 2011-05-26 Astrazeneca Ab Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases
GB201016912D0 (en) 2010-10-07 2010-11-24 Astrazeneca Ab Novel combination
GB201021992D0 (en) 2010-12-23 2011-02-02 Astrazeneca Ab Compound
GB201021979D0 (en) 2010-12-23 2011-02-02 Astrazeneca Ab New compound
PE20141378A1 (es) * 2011-03-18 2014-10-12 Corcept Therapeutics Inc Moduladores de receptores de glucocorticoides de pirimidina ciclohexilo
EP2915804B1 (en) * 2012-10-31 2019-03-27 FUJIFILM Toyama Chemical Co., Ltd. Novel amine derivative or salt thereof as tnf alpha inhibitors
EP2968358A4 (en) * 2013-03-15 2016-08-10 Ariad Pharma Inc NOVEL CHOLINKINASE INHIBITORS
WO2016029216A2 (en) * 2014-08-22 2016-02-25 Biocryst Pharmaceuticals, Inc. Method for producing amidine derivatives
KR101671404B1 (ko) * 2014-09-02 2016-11-02 한국원자력의학원 항암 효과, 방사선 병용치료 효과 및 당뇨병 치료 효과를 갖는 피리미딘 유도체 및 이의 의학적 용도
CN107709314A (zh) 2015-06-11 2018-02-16 巴斯利尔药物国际股份公司 外排泵抑制剂及其治疗性用途
CN106946851B (zh) * 2017-03-14 2019-11-12 牡丹江医学院 一种用于预防和治疗肾结石的药物
CN111683937A (zh) 2018-01-19 2020-09-18 爱杜西亚药品有限公司 C5a受体调节剂

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE791474A (fr) * 1971-11-25 1973-03-16 Yamanouchi Pharma Co Ltd Procede de preparation de derives d'acides cycloalcoylaminoarylcarboxyliques
US3838156A (en) * 1973-03-29 1974-09-24 Sterling Drug Inc Certain 2-substituted-6-(3 or 4-pyridyl)-nicotinic acid derivatives
US4205073A (en) * 1975-04-30 1980-05-27 Schering Corporation Anti-diarrheal anilino nicotinic acids and method of using same
US4851535A (en) * 1985-01-23 1989-07-25 Toyama Chemical Co., Ltd. Nicotinic acid derivatives
JPH0629247B2 (ja) * 1985-01-23 1994-04-20 富山化学工業株式会社 ５−フルオロニコチン酸誘導体およびその塩
PH23853A (en) * 1986-08-21 1989-11-23 Pfizer Pyridopyrimidinediones
US5264437A (en) * 1992-03-20 1993-11-23 Syntex (U.S.A.) Inc. Optionally substituted pyrido[2,3-d]pyridine-2,4(1H,3H)-diones and pyrido[2,]pyrimidine-2(1H,3H)-ones
TW299333B (es) * 1992-12-29 1997-03-01 Takeda Pharm Industry Co Ltd
GB9420168D0 (en) * 1994-10-06 1994-11-23 Boots Co Plc Therapeutic agents
JPH10298164A (ja) * 1997-02-27 1998-11-10 Tanabe Seiyaku Co Ltd イソキノリノン誘導体、その製法及びその合成中間体
TWI243055B (en) * 2000-04-13 2005-11-11 Nippon Zoki Pharmaceutical Co Pharmaceutical composition for use in treatment of dermatitis
JP2002308774A (ja) * 2001-04-12 2002-10-23 Nippon Zoki Pharmaceut Co Ltd Ｉｖ型ホスホジエステラーゼ選択的阻害剤
EP1551834B1 (en) * 2002-05-23 2010-08-25 Novartis Vaccines and Diagnostics, Inc. Substituted quinazolinone compounds
GB0217225D0 (en) * 2002-07-25 2002-09-04 Glaxo Group Ltd Medicinal compounds
US6909002B2 (en) * 2002-11-22 2005-06-21 Merck & Co., Inc. Method of preparing inhibitors of phosphodiesterase-4
US20040242583A1 (en) * 2003-01-20 2004-12-02 Aventis Pharma Deutschland Gmbh Pyrimido[5,4-e][1,2,4]triazine-5,7-diones, processes for preparing them and their use
AR049418A1 (es) * 2004-02-27 2006-08-02 Bayer Pharmaceuticals Corp Derivados de heteroarilaminopirazol y composiciones farmaceuticas para el tratamiento de la diabetes.
US7378423B2 (en) * 2004-06-11 2008-05-27 Japan Tobacco Inc. Pyrimidine compound and medical use thereof
FR2873118B1 (fr) * 2004-07-15 2007-11-23 Sanofi Synthelabo Derives de pyrido-pyrimidine, leur application en therapeutique
EP1789416B1 (en) * 2004-08-31 2009-03-11 F. Hoffmann-la Roche AG Amide derivatives of 3-phenyl dihydropyrimido[4,5-d]pyrimidinones, their manufacture and use as pharmaceutical agents
JP2006124387A (ja) * 2004-09-30 2006-05-18 Taisho Pharmaceut Co Ltd 新規なキノリン、テトラヒドロキナゾリン、及びピリミジン誘導体と、これらを使用することに関連した治療方法
DE102004050283A1 (de) * 2004-10-15 2006-04-27 Lanxess Deutschland Gmbh 4-Aminophenyl-morpholinon-Derivate und deren Herstellung
TW200726767A (en) * 2005-07-04 2007-07-16 Astrazeneca Ab Chemical compounds 2
TW200800997A (en) * 2006-03-22 2008-01-01 Astrazeneca Ab Chemical compounds
DE602007006927D1 (en) * 2006-03-23 2010-07-15 Actelion Pharmaceuticals Ltd Antibiotische cyclohexyl- oder piperidinylcarboxamid-derivate
GB0613836D0 (en) * 2006-07-13 2006-08-23 Univ Greenwich New medical use of triazine derivatives
JO2985B1 (ar) * 2006-12-20 2016-09-05 Takeda Pharmaceuticals Co مثبطات كينازmapk/erk
TW200835497A (en) * 2007-01-11 2008-09-01 Astrazeneca Ab Chemical compounds 636
SA08280783B1 (ar) * 2007-01-11 2011-04-24 استرازينيكا ايه بي مشتقات بيريدوبيريميدين كمثبطات pde4
MY150697A (en) * 2007-04-10 2014-02-28 Exelixis Inc Methods of treating cancer using pyridopyrimdinone inhibitors of p13k alpha
EP2315755B1 (en) * 2008-05-13 2012-08-08 Boehringer Ingelheim International GmbH SYNTHESIS OF DIHYDROTHIENO[3,2-d]PYRIMIDINE DIOLS AND SIMILAR PYRIMIDINE DIOLS
US20110166144A1 (en) * 2008-07-31 2011-07-07 The Regents Of The University Of Michigan Pyrimidotriazinediones and Pyrimidopyrimidinediones and Methods of Using the Same
EP2391624B1 (en) * 2009-01-30 2013-01-16 Boehringer Ingelheim International GmbH Azaquinazolinediones useful as chymase inhibitors

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CN101636388B (zh) 2013-09-18
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MY162022A (en) 2017-05-31
MX2009007231A (es) 2009-07-14
CL2008000089A1 (es) 2008-11-03
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BRPI0806689A2 (pt) 2015-07-21
CA2674647A1 (en) 2008-07-17
WO2008084223A3 (en) 2008-10-02
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SA08280783B1 (ar) 2011-04-24
US20120077801A1 (en) 2012-03-29
US20100204203A1 (en) 2010-08-12
CO6210698A2 (es) 2010-10-20
ECSP099480A (es) 2009-08-28
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UY30863A1 (es) 2008-09-02
TW200836745A (en) 2008-09-16
EP2106396B1 (en) 2014-09-24
KR20090101303A (ko) 2009-09-24
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