Nothing Special   »   [go: up one dir, main page]

PA8527901A1 - DERIVATIVES OF QUINAZOLIN AS AN ANTAGONIST OF ADRENÈRGICO ALFA-1 - Google Patents

DERIVATIVES OF QUINAZOLIN AS AN ANTAGONIST OF ADRENÈRGICO ALFA-1

Info

Publication number
PA8527901A1
PA8527901A1 PA20018527901A PA8527901A PA8527901A1 PA 8527901 A1 PA8527901 A1 PA 8527901A1 PA 20018527901 A PA20018527901 A PA 20018527901A PA 8527901 A PA8527901 A PA 8527901A PA 8527901 A1 PA8527901 A1 PA 8527901A1
Authority
PA
Panama
Prior art keywords
alfa
antagonist
adrenèrgico
quinazolin
derivatives
Prior art date
Application number
PA20018527901A
Other languages
Spanish (es)
Inventor
Cyrus Kephra Becker
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PA8527901A1 publication Critical patent/PA8527901A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Urology & Nephrology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LA INVENCION, SE REFIERE A COMPUESTOS QUE SON DE UNA FORMULA GENERAL ANTAGONISTAS DEL RECEPTOR ADRENERGICO ALFA-1B, Y LOS CUALES SE REPRESENTAN POR LA FORMA GENERAL I EN DONDE, R1,R2, m, n, Y A, SON TAL Y COMO SE DEFINE EN LA ESPECIAFICACION, O PROFARMACO, ISOMEROS INDIVIDUALES, MEZCLAS DE ISOMEROS, RACEMICAS O NO RECEMICAS, O SALES O SOLVATOS FARMACEUTICAMENTE ACEPTABLES DE ESTOS. LA INVENCION, SE REFIERE ASIMISMO A COMPOSICIONES FARMACEUTICAS QUE CONTIENEN TALES TIPOS DE COMPONENTES, AL USO DE TALES TIPOS DE COMPUESTOS, EN EL CONTROL Y LA PREVENCION DE ENFERMEDADES, TALES COMO LOS TRASTORNOS DEL TRACTO URINERIO, LA DISFUNCION SEXUAL, EL DOLOR, O LOS TRASTORNOS DEL SISTEMA NERVIOSO CENTRAL, Y PROCEDIMIENTOS PARA LA PREPARACION DE ESTOS.THE INVENTION REFERS TO COMPOUNDS THAT ARE OF AN ANTAGONIST GENERAL FORM OF THE ALFA-1B ADRENERGIC RECEIVER, AND WHICH ARE REPRESENTED BY THE GENERAL FORM I WHERE, R1, R2, m, n, ALREADY ARE, AS DEFINED IN THE SPECIFICATION, OR PROFARMACO, INDIVIDUAL ISOMERS, MIXTURES OF ISOMEROS, RACEMIC OR NON-RECEMICAL, OR SALTS OR SOLVATOS PHARMACEUTICALLY ACCEPTABLE OF THESE. THE INVENTION REFERS ASYMISM TO PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH TYPES OF COMPONENTS, TO THE USE OF SUCH TYPES OF COMPOUNDS, IN THE CONTROL AND PREVENTION OF DISEASES, SUCH AS URINARY TRACT DISORDERS, SEXUAL DYSFUNCTION, SEXUAL DYSFUNCTION, DISORDERS OF THE CENTRAL NERVOUS SYSTEM, AND PROCEDURES FOR THE PREPARATION OF THESE.

PA20018527901A 2000-08-31 2001-08-30 DERIVATIVES OF QUINAZOLIN AS AN ANTAGONIST OF ADRENÈRGICO ALFA-1 PA8527901A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US22950300P 2000-08-31 2000-08-31

Publications (1)

Publication Number Publication Date
PA8527901A1 true PA8527901A1 (en) 2002-07-30

Family

ID=22861517

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20018527901A PA8527901A1 (en) 2000-08-31 2001-08-30 DERIVATIVES OF QUINAZOLIN AS AN ANTAGONIST OF ADRENÈRGICO ALFA-1

Country Status (19)

Country Link
US (1) US6559153B2 (en)
EP (1) EP1315714B1 (en)
JP (1) JP3971299B2 (en)
KR (1) KR100602929B1 (en)
CN (1) CN1308324C (en)
AR (1) AR032475A1 (en)
AT (1) ATE309240T1 (en)
AU (2) AU2001293788B2 (en)
BR (1) BR0113585A (en)
CA (1) CA2420177C (en)
DE (1) DE60114852T2 (en)
ES (1) ES2251512T3 (en)
GT (1) GT200100181A (en)
MX (1) MXPA03001777A (en)
PA (1) PA8527901A1 (en)
PE (1) PE20020407A1 (en)
UY (1) UY26919A1 (en)
WO (1) WO2002018348A2 (en)
ZA (1) ZA200301082B (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003014122A1 (en) * 2001-08-10 2003-02-20 Polychip Pharmaceuticals Pty Ltd Derivatives of morphine-like opioid compounds
WO2003082825A1 (en) * 2002-04-03 2003-10-09 Orion Corporation Use of an alfa2-adrenoreceptor antagonist for cns-related diseases
TW200403058A (en) * 2002-04-19 2004-03-01 Bristol Myers Squibb Co Heterocyclo inhibitors of potassium channel function
ITMI20030151A1 (en) * 2003-01-30 2004-07-31 Recordati Ind Chimica E Farma Ceutica S P A USE OF SELECTIVE MGLU5 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF NEUROMUSCULAR DYSFUNCTIONS OF THE LOWER URINARY TRACT.
DE602004022819D1 (en) * 2003-06-06 2009-10-08 Vertex Pharma TRANSPORTER OF ATP-BINDING CASSETTE
DK1648878T3 (en) * 2003-07-24 2009-08-10 Euro Celtique Sa Piperidine compounds and pharmaceutical compositions containing them
WO2006021345A2 (en) * 2004-08-27 2006-03-02 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with adrenergic alpha-1b receptor (adra1b)
MY179032A (en) 2004-10-25 2020-10-26 Cancer Research Tech Ltd Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors
US7413607B2 (en) * 2005-03-31 2008-08-19 3M Innovative Properties Company Templated semiconductor particles and methods of making
US7344583B2 (en) * 2005-03-31 2008-03-18 3M Innovative Properties Company Methods of making metal particles within cored dendrimers
EP1888538B1 (en) * 2005-05-04 2009-11-18 F. Hoffmann-Roche AG (3,4-dihydro-quinazolin-2-yl)-(2-aryloxy-ethyl)-amines having an activity on the 5-ht receptor
ES2878130T3 (en) 2006-04-25 2021-11-18 Astex Therapeutics Ltd Derivatives of purine and deazapurine as pharmaceutical compounds
EP2066584A2 (en) * 2006-09-19 2009-06-10 3M Innovative Properties Company Templated metal oxide particles and methods of making
BRPI0818533B8 (en) 2007-10-11 2021-05-25 Astrazeneca Ab compound, pharmaceutical composition, use of a compound, and, process for preparing a compound
TW200944526A (en) * 2008-04-22 2009-11-01 Vitae Pharmaceuticals Inc Carbamate and urea inhibitors of 11β-hydroxysteroid dehydrogenase 1
RS59568B1 (en) 2011-04-01 2019-12-31 Astrazeneca Ab Therapeutic treatment
EP2785349B2 (en) 2011-11-30 2022-11-09 Astrazeneca AB Combination treatment of cancer
AU2013204533B2 (en) 2012-04-17 2017-02-02 Astrazeneca Ab Crystalline forms
BR112019018774A2 (en) * 2017-03-12 2020-04-07 Wang Xiaodong compound having a structure according to formula i, pharmaceutically acceptable salt, pharmaceutical composition, method for preventing or treating a disease or condition and method for immunomodulation, inhibiting or preventing rejection of organ or skin grafts or treating tumors or cancer
WO2019088095A1 (en) * 2017-11-02 2019-05-09 国立大学法人九州大学 Analgesic and use thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997011698A1 (en) 1995-09-29 1997-04-03 Merck & Co., Inc. ALPHA 1b ADRENERGIC RECEPTOR ANTAGONISTS
NZ325248A (en) * 1995-12-23 1999-09-29 Pfizer Res & Dev Quinoline and quinazoline compounds useful in therapy
GB9700504D0 (en) 1997-01-11 1997-02-26 Pfizer Ltd Pharmaceutical compounds
US6355641B1 (en) 1999-03-17 2002-03-12 Syntex (U.S.A.) Llc Oxazolone derivatives and uses thereof

Also Published As

Publication number Publication date
DE60114852T2 (en) 2006-07-27
CA2420177C (en) 2008-07-08
US6559153B2 (en) 2003-05-06
AR032475A1 (en) 2003-11-12
KR100602929B1 (en) 2006-07-20
ATE309240T1 (en) 2005-11-15
WO2002018348A2 (en) 2002-03-07
PE20020407A1 (en) 2002-05-21
JP3971299B2 (en) 2007-09-05
AU2001293788B2 (en) 2007-10-11
UY26919A1 (en) 2002-02-28
CN1308324C (en) 2007-04-04
GT200100181A (en) 2002-05-23
US20020045614A1 (en) 2002-04-18
ES2251512T3 (en) 2006-05-01
DE60114852D1 (en) 2005-12-15
BR0113585A (en) 2003-07-29
EP1315714B1 (en) 2005-11-09
ZA200301082B (en) 2004-05-07
CA2420177A1 (en) 2002-03-07
MXPA03001777A (en) 2003-06-04
AU9378801A (en) 2002-03-13
CN1545510A (en) 2004-11-10
JP2004507527A (en) 2004-03-11
KR20030022421A (en) 2003-03-15
EP1315714A2 (en) 2003-06-04
WO2002018348A3 (en) 2002-07-11

Similar Documents

Publication Publication Date Title
PA8527901A1 (en) DERIVATIVES OF QUINAZOLIN AS AN ANTAGONIST OF ADRENÈRGICO ALFA-1
PA8547901A1 (en) 4-PIPERACINYLINDOL DERIVATIVES WITH 5-HT6 RECEPTOR AFFINITY
ECSP034562A (en) B3-ADRENERGIC RECEIVER AGONIST AND USES OF THE SAME
ECSP066520A (en) DERIVATIVES OF DIHYDROBENZOFURANYL ALCANAMINE AND METHODS FOR USE
ECSP034602A (en) SUBSTITUTED DERIVATIVES 2-PHENYLAMINOIMIDAZOLINE PHENYL KETONE AS IP ANTAGONISTS
CR8094A (en) IMIDAZOL DERIVATIVES ANTAGONISTS OF THE GLUTAMATE RECEIVER
UY30411A1 (en) SUBSTITUTED DERIVATIVES OF THE ACETATE OF 2,3,4, -TETRAHYDROIMIDAZO- [1,5-A] -PIRIMIDIN-6-AMINA, PHARMACEUTICAL COMPOSITIONS AND APPLICATIONS
SV2002000504A (en) REPLACED BICYCLE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELLULAR GROWTH REF.PC10760 / 20205 / BB
GT200100137A (en) PRO-DRUGS OF 4-PHENYL-PYRIDINE DERIVATIVES.
ECSP034428A (en) CYCLOPENTHANOLS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND THEIR USE
AR023574A1 (en) TETRACICLIC AZEPININDOL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND THE USE OF SUCH COMPOUNDS TO PREPARE A MEDICINAL PRODUCT, AND INTERMEDIARIES
DOP2001000271A (en) IMIDAZOL COMPOUNDS CONDENSED WITH ARILO OR HETEROARILO AS ANTI-INFLAMMATORY AND ANALGESIC AGENTS.
PA8587101A1 (en) NEW DERIVATIVES OF DIHYDROPIRIMIDO [4,5-D] PIRIMIDINONE REPLACED BY AMIINO, MANUFACTURE AND USE OF THE SAME AS PHARMACEUTICAL AGENTS
UY28374A1 (en) THERAPEUTIC AGENTS
PA8556901A1 (en) NEW DERIVATIVES OF PIPERAZINA
PL361361A1 (en) Substituted 1-aminoalkyl-lactams and their use as muscarinic receptor antagonists
ECSP088967A (en) MUSCARINIC RECEIVER AGONISTS THAT ARE EFFECTIVE IN THE TREATMENT OF PAIN, ALZHEIMER'S DISEASE AND SCHIZOPHRENIA
PL361282A1 (en) Substituted 1-aminoalkyl-lactams and their use as muscarinic receptor antagonists
PA8561501A1 (en) LACTAMAS AS TAQUIQUININE ANTAGONISTS
AR029428A1 (en) PHENYL DERIVATIVES - PIPERIDINE, TETRAHIDROPIRIDINA, -PIPERAZINA, -AZEPAN, -TETRAHIDRO-1H-AZEPINA AND DIAZEPAN SUBSTITUTED, A PHARMACEUTICAL COMPOSITION AND THE USE OF THE SAME FOR THE MANUFACTURE OF A PHARMACEUTICAL PREPARATION
UY28377A1 (en) THERAPEUTIC AGENTS
ECSP19084722A (en) 5,6-FUSED BICYCLIC COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES
AR037611A1 (en) COMPOUNDS DERIVED FROM AMINO-TETRALINA, ITS USE, A PROCEDURE FOR THE PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT UNDERSTAND THEM
BRPI0410237A (en) methyl indoles and methyl pyrrolopyridines as alpha-1 adrenergic agonists
GT200000087A (en) POLYMORPH FORMS OF A AZABICICLO CITRATE (2.2.2) OCTAN - 3 - AMINA AND ITS PHARMACEUTICAL COMPOSITIONS.