LV10251B - Method of preparation of hypuric acid salts of 4-(di-n-propyl)amino-6-aminocarbonil-1,3,4,5-tetrahydrobenz£c,d|indole - Google Patents

Method of preparation of hypuric acid salts of 4-(di-n-propyl)amino-6-aminocarbonil-1,3,4,5-tetrahydrobenz£c,d|indole

Info

Publication number: LV10251B
Authority: LV; Latvia
Prior art keywords: tetrahydrobenz; propyl; amino; preparation; indole
Prior art date: 1990-02-26

Application number

LVP-93-509A

Other languages

English (en)

Other versions

LV10251A (lv

Inventor

Thomas Joseph Kress

David Lee Varie

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-02-26

Filing date

1993-06-08

Publication date

1995-04-20

1993-06-08 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1994-10-20 Publication of LV10251A publication Critical patent/LV10251A/xx

1995-04-20 Publication of LV10251B publication Critical patent/LV10251B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/90—Benzo [c, d] indoles; Hydrogenated benzo [c, d] indoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Addiction (AREA)
Diabetes (AREA)
Obesity (AREA)
Hematology (AREA)
Child & Adolescent Psychology (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Indole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

LVP-93-509A 1990-02-26 1993-06-08 Method of preparation of hypuric acid salts of 4-(di-n-propyl)amino-6-aminocarbonil-1,3,4,5-tetrahydrobenz£c,d|indole LV10251B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US48518590A	1990-02-26	1990-02-26

Publications (2)

Publication Number	Publication Date
LV10251A LV10251A (lv)	1994-10-20
LV10251B true LV10251B (en)	1995-04-20

Family

ID=23927224

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LVP-93-509A LV10251B (en)	1990-02-26	1993-06-08	Method of preparation of hypuric acid salts of 4-(di-n-propyl)amino-6-aminocarbonil-1,3,4,5-tetrahydrobenz£c,d\|indole

Country Status (28)

Country	Link
US (1)	US5397799A (el)
EP (1)	EP0444852B1 (el)
JP (1)	JP3157007B2 (el)
KR (1)	KR100208114B1 (el)
CN (1)	CN1027503C (el)
AT (1)	ATE126506T1 (el)
AU (1)	AU629453B2 (el)
BR (1)	BR9100767A (el)
CA (1)	CA2037099C (el)
CY (1)	CY1887A (el)
DE (1)	DE69112099T2 (el)
DK (1)	DK0444852T3 (el)
ES (1)	ES2077796T3 (el)
FI (1)	FI95464C (el)
GR (1)	GR3017940T3 (el)
HK (1)	HK175495A (el)
HU (1)	HU217118B (el)
IE (1)	IE67801B1 (el)
IL (1)	IL97306A (el)
LV (1)	LV10251B (el)
NO (1)	NO174149C (el)
NZ (1)	NZ237181A (el)
PT (1)	PT96852B (el)
RU (2)	RU2034837C1 (el)
SG (1)	SG69975A1 (el)
TW (1)	TW219933B (el)
YU (1)	YU47594B (el)
ZA (1)	ZA911258B (el)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL97308A (en) *	1990-02-26	1996-10-31	Lilly Co Eli	Xahydrobenz [DC] Induced indoles in position 6, their preparation process and pharmaceutical preparations containing them
US5302612A (en) *	1990-02-26	1994-04-12	Eli Lilly And Company	6-substituted-hexahydrobenz[cd]indoles
IL97309A (en) *	1990-02-26	1996-11-14	Lilly Co Eli	Intermediates for hexahydrobenz] [DC indoles and a process for making their pure enantiomers
US5641794A (en) *	1991-03-28	1997-06-24	Eli Lilly Company	6-heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz[cd]indoles
US5364856A (en) *	1991-03-28	1994-11-15	Eli Lilly And Company	6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz[CD]indoles
TW248556B (el) *	1993-01-18	1995-06-01	Takeda Pharm Industry Co
US7588924B2 (en)	2006-03-07	2009-09-15	Procter & Gamble Company	Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase
HUE041300T2 (hu)	2006-06-26	2019-05-28	Akebia Therapeutics Inc	Prolilhidroxiláz inhibitorok és alkalmazási eljárások
PL2496084T3 (pl)	2009-11-06	2015-09-30	Aerpio Therapeutics Inc	Kompozycje oraz metody leczenia zapalenia jelita grubego
NO2686520T3 (el)	2011-06-06	2018-03-17
CN103717214A (zh)	2011-06-06	2014-04-09	阿克比治疗有限公司	用于稳定低氧诱导因子-2α作为治疗癌症的方法的化合物和组合物
HRP20240319T1 (hr)	2013-06-13	2024-05-24	Akebia Therapeutics, Inc.	Pripravci i postupci za liječenje anemije
KR102495018B1 (ko)	2013-11-15	2023-02-06	아케비아 테라퓨틱스 인코포레이티드	｛[5-(3-클로로페닐)-3-하이드록시피리딘-2-카보닐]아미노｝아세트산의 고체형, 이의 조성물 및 용도
CN107427503A (zh)	2015-01-23	2017-12-01	阿克比治疗有限公司	2‑(5‑(3‑氟苯基)‑3‑羟基吡啶甲酰胺)乙酸的固体形式、其组合物及用途
US11324734B2 (en)	2015-04-01	2022-05-10	Akebia Therapeutics, Inc.	Compositions and methods for treating anemia
AU2019265629B2 (en)	2018-05-09	2024-09-12	Akebia Therapeutics, Inc.	Process for preparing 2-((5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl)amino)acetic acid
US11524939B2 (en)	2019-11-13	2022-12-13	Akebia Therapeutics, Inc.	Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino} acetic acid

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4110339A (en) *	1977-11-25	1978-08-29	Eli Lilly And Company	4-(Di-n-propyl)amino-1,3,4,5-tetrahydrobenz[cd]indole
US4576959A (en) *	1984-02-06	1986-03-18	Eli Lilly And Company	6-Substituted-4-dialkylaminotetrahydrobenz[c,d]indoles
US4745126A (en) *	1987-03-12	1988-05-17	Eli Lilly And Company	Method of treating anxiety with tetrahydrobenz[c,d]indole-6-carboxamides
DE3809155A1 (de) *	1988-03-18	1989-09-28	Bayer Ag	1,3,4,5-tetrahydrobenz-(c,d)-indole
US5204340A (en) *	1989-04-11	1993-04-20	Eli Lilly And Company	Tetrahydrobenz(c,d)indole serotonin agonists
US5229409A (en) *	1990-08-15	1993-07-20	Eli Lilly And Company	6-substituted-tetrahydrobenz[cd]indoles

1990
- 1990-06-26 TW TW079105258A patent/TW219933B/zh active
1991
- 1991-02-20 ZA ZA911258A patent/ZA911258B/xx unknown
- 1991-02-20 IL IL9730691A patent/IL97306A/en not_active IP Right Cessation
- 1991-02-21 NZ NZ237181A patent/NZ237181A/en unknown
- 1991-02-22 PT PT96852A patent/PT96852B/pt not_active IP Right Cessation
- 1991-02-22 JP JP05064391A patent/JP3157007B2/ja not_active Expired - Fee Related
- 1991-02-25 NO NO910735A patent/NO174149C/no unknown
- 1991-02-25 HU HU91629A patent/HU217118B/hu unknown
- 1991-02-25 KR KR1019910003029A patent/KR100208114B1/ko not_active IP Right Cessation
- 1991-02-25 IE IE62591A patent/IE67801B1/en not_active IP Right Cessation
- 1991-02-25 AU AU71971/91A patent/AU629453B2/en not_active Ceased
- 1991-02-25 RU SU914894699A patent/RU2034837C1/ru not_active IP Right Cessation
- 1991-02-25 YU YU32791A patent/YU47594B/sh unknown
- 1991-02-25 FI FI910895A patent/FI95464C/fi active
- 1991-02-26 DE DE69112099T patent/DE69112099T2/de not_active Expired - Fee Related
- 1991-02-26 ES ES91301501T patent/ES2077796T3/es not_active Expired - Lifetime
- 1991-02-26 DK DK91301501.2T patent/DK0444852T3/da active
- 1991-02-26 CN CN91101296A patent/CN1027503C/zh not_active Expired - Fee Related
- 1991-02-26 AT AT91301501T patent/ATE126506T1/de not_active IP Right Cessation
- 1991-02-26 EP EP91301501A patent/EP0444852B1/en not_active Expired - Lifetime
- 1991-02-26 CA CA002037099A patent/CA2037099C/en not_active Expired - Fee Related
- 1991-02-26 BR BR919100767A patent/BR9100767A/pt not_active Application Discontinuation
- 1991-02-26 SG SG1996007257A patent/SG69975A1/en unknown
1992
- 1992-12-03 RU RU9292004575A patent/RU2083561C1/ru not_active IP Right Cessation
1993
- 1993-05-19 US US08/064,539 patent/US5397799A/en not_active Expired - Lifetime
- 1993-06-08 LV LVP-93-509A patent/LV10251B/xx unknown
1995
- 1995-11-01 GR GR950403048T patent/GR3017940T3/el unknown
- 1995-11-16 HK HK175495A patent/HK175495A/xx not_active IP Right Cessation
1996
- 1996-04-05 CY CY188796A patent/CY1887A/xx unknown

Also Published As

Publication number	Publication date
RU2034837C1 (ru)	1995-05-10
KR910021375A (ko)	1991-12-20
YU47594B (sh)	1995-10-24
JP3157007B2 (ja)	2001-04-16
CA2037099A1 (en)	1991-08-27
FI95464B (fi)	1995-10-31
CY1887A (en)	1996-04-05
IL97306A0 (en)	1992-05-25
NZ237181A (en)	1992-06-25
NO910735D0 (no)	1991-02-25
RU2083561C1 (ru)	1997-07-10
GR3017940T3 (en)	1996-02-29
DK0444852T3 (da)	1995-12-11
ES2077796T3 (es)	1995-12-01
PT96852A (pt)	1991-10-31
FI910895A (fi)	1991-08-27
EP0444852A2 (en)	1991-09-04
YU32791A (sh)	1994-01-20
FI95464C (fi)	1996-02-12
IE67801B1 (en)	1996-05-01
US5397799A (en)	1995-03-14
SG69975A1 (en)	2000-01-25
KR100208114B1 (ko)	1999-07-15
AU7197191A (en)	1991-08-29
CN1027503C (zh)	1995-01-25
NO910735L (no)	1991-08-27
NO174149B (no)	1993-12-13
EP0444852B1 (en)	1995-08-16
LV10251A (lv)	1994-10-20
FI910895A0 (fi)	1991-02-25
TW219933B (el)	1994-02-01
ATE126506T1 (de)	1995-09-15
HK175495A (en)	1995-11-24
PT96852B (pt)	1998-07-31
IE910625A1 (en)	1991-08-28
CA2037099C (en)	2001-09-11
AU629453B2 (en)	1992-10-01
ZA911258B (en)	1992-10-28
IL97306A (en)	1996-10-16
NO174149C (no)	1994-03-23
HUT56542A (en)	1991-09-30
JPH04217662A (ja)	1992-08-07
DE69112099T2 (de)	1996-02-08
HU217118B (hu)	1999-11-29
DE69112099D1 (de)	1995-09-21
CN1054589A (zh)	1991-09-18
EP0444852A3 (en)	1992-02-19
BR9100767A (pt)	1991-10-29

Publication	Publication Date	Title
LV10251B (en)	1995-04-20	Method of preparation of hypuric acid salts of 4-(di-n-propyl)amino-6-aminocarbonil-1,3,4,5-tetrahydrobenz£c,d\|indole
IE782325L (en)	1979-05-25	TETRAHYDROBENZ £cd\| INDOLES
AU2378988A (en)	1989-04-20	4-(N-3-pyridylmethyl)-amino-1,2,4-triazinones
TW239862B (el)	1995-02-01
AU7941691A (en)	1992-01-02	Antimigraine alkoxypyrimidine derivatives
AU3122789A (en)	1989-09-28	Skin improving composition and method using GLA and/or DGLA
EP0276543A3 (en)	1989-08-30	Use of buspirone for the improvement of short term memory
RU92004575A (ru)	1995-09-27	Кристаллическая соль 4-(ди-н-пропил) амино-6-аминокарбонил-1,3,4,5-тетрагидробенз (cd) индола и ее 4p и 4s-изомеры
AU623688B2 (en)	1992-05-21	Substituted 1,4-dihydro-4-oxo-1-pyrodinyl- (quinoline or naphthyridine) derivatives
AU597017B2 (en)	1990-05-24	3-(2-aminoethyl) indoles derivatives
EP0462837A3 (en)	1992-09-23	Preparation of indole derivatives
PH23992A (en)	1990-02-09	Optically active 2,3-dihydrobenzoxazine derivatives and process for preparing the same
AU590603B2 (en)	1989-11-09	A method of preparing indoles or indole derivatives, coupled via position 4, 5, 6, or 7, the indoles or indole derivatives concerned, as well as the use thereof
AU1951388A (en)	1989-10-05	Method of sterilizing anthers utilizing carboxylic acid derivatives
AU2803689A (en)	1989-04-18	Certain 3-substituted 2- alkyl indole derivatives
AU609158B2 (en)	1991-04-26	Method of sterilizing anthers utilizing substituted maleamino acids
GB9024172D0 (en)	1990-12-19	Method of generating an'i.c.inserted'signal automatically for an i.c.socket
EP0275104A3 (en)	1989-08-30	Process for preparing 2,3-dihydro-1h-imidazolylalkoxyindene derivatives and pharmaceutically acceptable salts
PL274219A1 (en)	1990-02-19	Method of obtaining novel derivatives of 4-oxo-1,2,3,4-tetrahydrocinnoline