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LTIP441A - Microcapsules and process for preparing thereof - Google Patents

Microcapsules and process for preparing thereof

Info

Publication number
LTIP441A
LTIP441A LTIP441A LTIP441A LTIP441A LT IP441 A LTIP441 A LT IP441A LT IP441 A LTIP441 A LT IP441A LT IP441 A LTIP441 A LT IP441A LT IP441 A LTIP441 A LT IP441A
Authority
LT
Lithuania
Prior art keywords
preparing
layer containing
water
oil emulsion
oil
Prior art date
Application number
LTIP441A
Inventor
Hiroaki Okada
Yayoi Inoue
Yasuaki Ogawa
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of LTIP441A publication Critical patent/LTIP441A/en
Publication of LT3278B publication Critical patent/LT3278B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A61K38/066—TRH, thyroliberin, thyrotropin releasing hormone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Reproductive Health (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Peptides Or Proteins (AREA)

Abstract

This invention provides a microcapsule designed for zero order release of a physiologically active polypeptide over a period of at least two months, which is produced by preparing a water-in-oil emulsion comprising an inner aqueous layer containing about 20 to 70% (w/w) of said polypeptide and an oil layer containing a copolymer or homopolymer having a weight-average molecular weight of 7,000 to 30,000, the molar composition ratio of lactic acid/glycolic acid being 80/20 to 100/0, subjecting said water-in oil emulsion to microencapsulation.
LTIP441A 1990-02-13 1993-03-19 Microcapsules and process for preparing thereof LT3278B (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP3313390 1990-02-13
JP889691 1991-01-29
JP3032302A JP2653255B2 (en) 1990-02-13 1991-01-31 Long-term sustained release microcapsules
CN91101017A CN1055618C (en) 1990-02-13 1991-02-12 Prolonged release microcapsules

Publications (2)

Publication Number Publication Date
LTIP441A true LTIP441A (en) 1994-11-25
LT3278B LT3278B (en) 1995-05-25

Family

ID=36754781

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP441A LT3278B (en) 1990-02-13 1993-03-19 Microcapsules and process for preparing thereof

Country Status (22)

Country Link
EP (1) EP0442671B1 (en)
JP (1) JP2653255B2 (en)
CN (1) CN1055618C (en)
AT (1) ATE123413T1 (en)
AU (1) AU645108B2 (en)
BR (1) BR9103553A (en)
CA (1) CA2036089C (en)
DE (1) DE69110150T2 (en)
DK (1) DK0442671T3 (en)
ES (1) ES2073117T3 (en)
FI (1) FI96278C (en)
HK (1) HK188095A (en)
HU (2) HU206986B (en)
IE (1) IE68436B1 (en)
LT (1) LT3278B (en)
LV (1) LV10041B (en)
MX (1) MX9100721A (en)
NO (1) NO301405B1 (en)
NZ (1) NZ239381A (en)
PT (1) PT96727B (en)
RU (2) RU2018306C1 (en)
UY (1) UY23276A1 (en)

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LV10041B (en) 1994-10-20
JPH04321622A (en) 1992-11-11
FI910674A0 (en) 1991-02-12
LV10041A (en) 1994-05-10
EP0442671B1 (en) 1995-06-07
DE69110150T2 (en) 1996-01-25
NZ239381A (en) 1992-12-23
IE68436B1 (en) 1996-06-12
EP0442671A2 (en) 1991-08-21
LT3278B (en) 1995-05-25
UY23276A1 (en) 1992-01-15
CA2036089C (en) 2000-12-05
PT96727B (en) 1998-07-31
CA2036089A1 (en) 1991-08-14
AU8179491A (en) 1992-08-06
MX9100721A (en) 1992-07-31
DE69110150D1 (en) 1995-07-13
HU206986B (en) 1993-03-01
ATE123413T1 (en) 1995-06-15
RU2018306C1 (en) 1994-08-30
CN1055618C (en) 2000-08-23
NO910555L (en) 1991-08-14
RU2098121C1 (en) 1997-12-10
CN1054009A (en) 1991-08-28
EP0442671A3 (en) 1992-09-02
HUT56268A (en) 1991-08-28
FI96278C (en) 1996-06-10
IE910474A1 (en) 1991-08-14
AU645108B2 (en) 1994-01-06
DK0442671T3 (en) 1995-07-24
PT96727A (en) 1991-10-31
ES2073117T3 (en) 1995-08-01
NO301405B1 (en) 1997-10-27
HU211586A9 (en) 1995-12-28
FI96278B (en) 1996-02-29
FI910674A (en) 1991-08-14
HK188095A (en) 1995-12-22
BR9103553A (en) 1992-09-29
JP2653255B2 (en) 1997-09-17
NO910555D0 (en) 1991-02-12

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