Nothing Special   »   [go: up one dir, main page]

KR830005866A - Method of manufacturing human insulin - Google Patents

Method of manufacturing human insulin Download PDF

Info

Publication number
KR830005866A
KR830005866A KR1019810002634A KR810002634A KR830005866A KR 830005866 A KR830005866 A KR 830005866A KR 1019810002634 A KR1019810002634 A KR 1019810002634A KR 810002634 A KR810002634 A KR 810002634A KR 830005866 A KR830005866 A KR 830005866A
Authority
KR
South Korea
Prior art keywords
human
cells
insulin
human insulin
producing
Prior art date
Application number
KR1019810002634A
Other languages
Korean (ko)
Other versions
KR860000894B1 (en
Inventor
가나메 스기모도
Original Assignee
하야시바라 겡
가부시기가이샤 하야시바라 세이부쓰 가가구 겡뀨우죠
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 하야시바라 겡, 가부시기가이샤 하야시바라 세이부쓰 가가구 겡뀨우죠 filed Critical 하야시바라 겡
Publication of KR830005866A publication Critical patent/KR830005866A/en
Application granted granted Critical
Publication of KR860000894B1 publication Critical patent/KR860000894B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Environmental Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Epidemiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

내용 없음No content

Description

인체 인슐린의 제조방법Method of manufacturing human insulin

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (5)

인체세포를 인체 이외의 온혈동물체에 이식하여 인체 인슐린을 생성할 수 있는 인체세포를 증식하고 이 증식된 세포를 인슐린 유도제를 작용시켜서 인체 인슐린을 유도 생성시키고 또는 인체 이외의 온혈동물의 영양체액이 세포에 공급되는 방법으로 세포가 증식되게 하여서 인체 인슐린을 생산할 수 있는 인체 세포를 증식하고 이 증식된 세포를 인슐린 유도제를 작용시커서 인체 인슐린을 유도 생성시키는 것을 특징으로 하는 인체 인슐린의 제조방법.Human cells are transplanted into warm-blooded animals other than the human body to proliferate human cells capable of producing human insulin, and the proliferated cells are induced to produce human insulin by acting insulin inducers or nutrient fluids from warm-blooded animals other than human body A method of producing human insulin, characterized by proliferating human cells capable of producing human insulin by proliferating the cells by a method supplied to the human body, and inducing and producing human insulin by acting an insulin inducing agent. 인체 인슐린을 생산할 수 있는 인체세포가, EB비루스가 X-선 조사로 종양화시킨 인체췌장 랑게르한스 설 β 세폴, 인체 종양세포, 인쳉 폐암종 세포, 또는 전술한 세포들의 주화세포인 청구 범위 제1항의 방법.Claim 1 of claim 1, wherein the human cells capable of producing human insulin are human pancreatic Langerhans Sul beta sepol, EB virus tumorized by X-ray irradiation, human tumor cells, human lung carcinoma cells, or coin cells of the aforementioned cells. Way. 인체 인슐린을 생산할 수 있는 인체세포가 청구범위 제 2항에 기재한 세포중의 하나와 인체 백혈병의 임파아구 세포의 세포융합으로 얻어진 잡종종류 세포인 청구범위 제1항의 방법.The method of claim 1, wherein the human cells capable of producing human insulin are hybrid type cells obtained by cell fusion of one of the cells according to claim 2 with lymphocytes of human leukemia. 전술한 인슐인 유도체가 글루코오스, 만노오스, 프룩토오스, 리보오스 및 크실리톨과 같은 당류, 아르기닌, 리신 및 류신과 같은 아너노산, 글루카콘 및 부신피질 자극호르몬과 같은 펩티드호르몬 및 K+및 Ca++와 같은 금속 양이온으로 된 기의 하나 또는 그 이상인 청구범위 제1항의 방법.The aforementioned insulin derivatives include sugars such as glucose, mannose, fructose, ribose and xylitol, anernoic acids such as arginine, lysine and leucine, peptide hormones such as glucacon and corticosteroids and K + and Ca The process of claim 1 which is one or more of a group of metal cations such as ++ . 전술한 인체 이외의 온혈동물이 닭 또는 비둘기와 같은 조류 또는 개, 고양이, 원숭이, 양, 돼지, 소, 말, 토끼, 기니아돼지, 쥐, 햄스터, 보통쥐 또는 누우드 마우스와 같은 포유류인 청구범위 제1항의 방법.Claims other than the above-mentioned warm-blooded animals are mammals, such as birds or dogs, such as chickens or pigeons, cats, monkeys, sheep, pigs, cattle, horses, rabbits, guinea pigs, mice, hamsters, rats, or wildwood mice The method of claim 1. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019810002634A 1980-07-30 1981-07-21 Producing method of human insulin KR860000894B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP80-104726 1980-07-30
JP10472680A JPS5729294A (en) 1980-07-30 1980-07-30 Preparation of human insulin

Publications (2)

Publication Number Publication Date
KR830005866A true KR830005866A (en) 1983-09-14
KR860000894B1 KR860000894B1 (en) 1986-07-16

Family

ID=14388494

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019810002634A KR860000894B1 (en) 1980-07-30 1981-07-21 Producing method of human insulin

Country Status (6)

Country Link
JP (1) JPS5729294A (en)
KR (1) KR860000894B1 (en)
CH (1) CH649782A5 (en)
FR (1) FR2487851A1 (en)
GB (1) GB2083826B (en)
IT (1) IT1196534B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58138395A (en) * 1982-02-12 1983-08-17 Hayashibara Biochem Lab Inc Production of human immune response suppression (hirs) factor
JPS5927286U (en) * 1982-08-16 1984-02-20 前沢化成工業株式会社 oil separation tank
DK402984D0 (en) * 1984-08-23 1984-08-23 Nordisk Insulinlab PROCEDURE FOR PROMOTING INSULIN-PRODUCING CELLS
EP0263908B1 (en) * 1986-10-15 1991-09-25 Battelle Memorial Institute Method for the production of proteins by means of inducible expression systems in genetically modified eukaryotic host-cells multiplicated in-vivo
FR2637613B1 (en) * 1987-06-19 1991-09-27 Transgene Sa PROCESS FOR THE PREPARATION OF STABLE CELL LINES FOR THE PRODUCTION OF DETERMINED PROTEINS FROM TRANSGENIC ANIMALS; TUMOR CELL LINES AND PROTEINS OBTAINED
ZA892518B (en) * 1988-04-08 1989-12-27 Intracel Corp Method for the in-vivo production and testing of proteins by recombinant gene expression in selected host-cells
GB9015327D0 (en) * 1990-07-12 1990-08-29 Tan Kim S Hybridomas
CN103168747B (en) * 2013-04-02 2015-12-09 陈景河 Improve the raising method of pigeon diseases prevention ability
CN104782569A (en) * 2015-04-16 2015-07-22 柳州市大金农业科技有限公司 Total-artificial young pigeon feeding method
CN107667981A (en) * 2017-11-24 2018-02-09 广西博白县圣德种养专业合作社 It is a kind of to hatch the high method of pigeon eggs rate
CN108513951A (en) * 2018-04-03 2018-09-11 英德市德丰农牧发展有限公司 A kind of pigeon for meat prevalent variety cultivation method
CN111838071B (en) * 2020-08-07 2022-05-03 江苏省家禽科学研究所 Method for breeding pigeons with black tail and/or phoenix head characters

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2757169A1 (en) * 1977-12-22 1979-07-05 Hoechst Ag METHOD OF OBTAINING INSULIN-PRODUCING ANIMAL CELLS
GB2016015B (en) * 1978-01-22 1982-05-06 Hayashibara Co Method of preparing interferon and preparations containing interferon

Also Published As

Publication number Publication date
FR2487851A1 (en) 1982-02-05
CH649782A5 (en) 1985-06-14
IT1196534B (en) 1988-11-16
JPS5729294A (en) 1982-02-17
IT8148915A0 (en) 1981-07-16
FR2487851B1 (en) 1984-12-14
GB2083826A (en) 1982-03-31
GB2083826B (en) 1983-11-30
JPS5756878B2 (en) 1982-12-01
KR860000894B1 (en) 1986-07-16

Similar Documents

Publication Publication Date Title
KR830005866A (en) Method of manufacturing human insulin
Altman et al. Post-natal origin of microneurones in the rat brain
McCORKLE JR et al. The morphology of the phytohemagglutinin-induced cell response in the chicken's wattle
Sell Distribution of α-fetoprotein-and albumin-containing cells in the livers of Fischer rats fed four cycles of N-2-fluorenylacetamide
PT93966A (en) NEW SYSTEM OF LIBERATION OF ANTIBODIES FOR BIOLOGICAL RESPONSE MODIFIERS
Stickney et al. Effect of gastric emptying upon propulsive motility of small intestine of rats.
Hammond et al. Monensin and the prevention of tryptophan-induced acute bovine pulmonary edema and emphysema
Johnston et al. Autoradiographic studies of the utilization of S35-sulfate by the chick embryo
Bird Changes associated with parasitism in nematodes. V. Ultrastructure of the stylet exudation and dorsal esophageal gland contents of female Meloidogyne javanica
Walker Skeletal muscle regeneration in young rats
KR830005868A (en) Method of manufacturing human growth hormone
Tsuji et al. Neuronal differentiation of oat cell carcinoma in vitro by dibutyryl cyclic adenosine 3′, 5′-monophosphate
Millhouse Jr et al. Long-term organ culture of the salamander heart
KR830007089A (en) Method of manufacturing human cell proliferation factor
Mohr et al. Incorporation of 3 H-proline into hyaline articular cartilage: An autoradiographic study in rats with and without adjuvant-induced arthritis
KR830007086A (en) Method of manufacturing human calcitonin
KR830007085A (en) Method of manufacturing human epidermal hormone
AR015237A1 (en) A COMPOSITION OF MODIFIED TUMOR CELL MEMBRANES WITH HAPTEN, METHOD FOR OBTAINING AND USE.
Brandes et al. Effect of vitamin A alcohol on the surface coat and charges of L1210 leukemic cells
DE3033562C2 (en) A polymerized composition having a cell or organelle immobilized therein and a method for its preparation.
KR830007090A (en) How to prepare human adrenal cortex stimulating hormone
KR830007087A (en) Method for preparing human thyroid stimulating hormone
Deschênes et al. The comparative effectiveness of the ‘brown and blue reactions’ for tracing neuronal processes of cells injected intracellularly with horseradish peroxidase
Freinkel et al. Effect of Pituitary Thyrotrophin on the Diglyceride/Triglyceride Interrelationships in Thyroid Tissue
Ball et al. A method of labelling living parasitic nematodes with carbon 14.

Legal Events

Date Code Title Description
E902 Notification of reason for refusal
G160 Decision to publish patent application
O035 Opposition [patent]: request for opposition

Free format text: OPPOSITION NUMBER: 001986002083; OPPOSITION DATE: 19860916

O122 Withdrawal of opposition [patent]
E701 Decision to grant or registration of patent right
O073 Decision to grant registration after opposition [patent]: decision to grant registration
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 19910610

Year of fee payment: 6

LAPS Lapse due to unpaid annual fee