KR20190083743A - Gel-inducible composition for pet medication aid and method of administration using the same - Google Patents

Abstract

The present invention relates to a gel induction-type composition for pet preparation medicine administration assistance and a method for administration using the same. The present invention provides the gel induction-type composition for pet preparation medicine administration assistance which optimizes viscosity according to a vegetable oil content in a base composition composed of a complex lactobacillus-containing group and an enzyme-containing group. A gel is formed by mixing a powdered medicine prepared by each prescription with the composition and the gel is attached to palate of pet by ladling the formed gel with a finger to let a gel induction-type composition component to melt, thereby allowing medicine to be naturally absorbed. Therefore, the gel induction-type composition reduces resistance by having a taste that pet likes, increases digestion absorption by adding enzymes, and can be provided in a customized preparation having a desired viscosity when mixed with a powdered medicine mixture prepared in a veterinary hospital.

Description

[0001] GEL-INDUCIBLE COMPOSITION FOR PET MEDICATION AID AND METHOD OF ADMINISTRATION USING THE SAME [0002]

The present invention relates to a gel-inducing composition for assisting the preparation of a pet pharmaceutical preparation and a method of administering the same, and more particularly, to a base composition comprising a complex-containing lactic acid bacteria-containing group and an enzyme- The present invention relates to a gel-inducing composition for auxiliary medicines and medicines, which comprises the steps of forming a gel by mixing a powdered medicament prepared according to each prescription into the above-mentioned composition, attaching the formed gel to the ceiling of a pet, The present invention relates to a pet pharmaceutical preparation medicament-assisted gel-inducible composition and a medicament using the same, wherein the medicament is naturally absorbed when the inductive composition component melts.

In modern society, pets are a companion animal with people, and dogs and cats are representative. They maintain a close relationship with people and grow up to receive more attention and caring than animals.

Therefore, when a pet animal is injured due to an abnormality in its health, it is diagnosed in a veterinary hospital, and the drug is taken. However, most of these drugs are formed into solid form and administered through the oral cavity. Are often refused to take the drug due to the smell of the drug, and the administration of the drug through the oral route is inconvenient and less than the dosage, thus requiring improvement.

As a part of this effort, an oral feeding container for pets (Patent Document 1) was designed to more easily feed liquid medicines and nutrients to pets, and the medicines were mixed with water, It is a method of forcibly administering to the oral cavity of a pet through a spoon or a syringe.

However, pets are not able to swallow properly due to the odor and bitter taste of the drug administered via the oral route, and the drug is spit out again, making it difficult to effectively treat the drug. Especially when using a syringe, From the second, there is a problem that it does not come close even if you take a syringe.

Another attempt has been made to provide a storage space in a pet feed for storing medicines in the form of solid, capsule or powder so that they can take the medicines contained in the feed while consuming the feed, (Patent Document 2). However, in this case, the sugar content is too high to cause another harmful problem to the body.

In addition, it has been proposed that oral administration to a pet can be made by freezing a capsule preparation in which the drug is administered in a hollow space (Patent Document 3)

However, it is still difficult to solve the problem of avoiding drugs when pesticides are administered to pets, and therefore there is a difficulty in dosing the proper amount.

The present inventors have made efforts to solve the problems of the prior art, and as a result, the present inventors have provided a pet-based pharmaceutical composition-assisting gel-inducing composition having viscosity optimized by vegetable oil in a base composition containing lactic acid bacteria and enzymes for pet, When the powdered medicament prepared according to each prescription is mixed and injected into the inductive composition, the mixture is mixed without layer separation between the gel-inductive composition and the powdered medicament. When the fingertip is released without flowing down, the whole mixture is attached to the pet mouth ceiling, Thereby allowing the drug to be naturally absorbed when the gel-derived composition component is melted, thereby completing the present invention.

Utility Model Registration No. 0329124 (September 26, 2003) Utility Model Publication No. 2017-0000112 (2017.01.09) U.S. Patent Application Publication No. 2012-0321703 (2012.12.20)

It is an object of the present invention to provide a gel-based composition for pet pharmaceutical dosage administration.

Another object of the present invention is to provide a method of administering a pet pharmaceutical preparation using the pet pharmaceutical preparation medicament-assisted gel-derived composition.

In order to accomplish the above object, the present invention provides a method for producing Bacillus subtilis , Enterococcus faecium , Lactobacillus acidophilus , Bifidobacterium longum and Bacillus subtilis , Bifidobacterium thermophilum , and an enzyme-containing group; and 5 to 20 parts by weight of vegetable oil per 100 parts by weight of the base composition The present invention provides a gel-derived composition for auxiliary preparation for pets, molded into a viscous material.

At this time, the viscosity of the viscous material preferably satisfies 700 cP or less as a result of measurement at a rotation speed of 140 to 200 rpm of a rotational viscometer at 25 ° C.

The gel-derived composition is provided in a stick package quantified as 5 to 10% of the standard daily food intake per day of the pet's body weight.

In addition, the present invention relates to a method for preparing a gel preparation composition, comprising the steps of charging a pet pharmaceutical preparation medicament-assisted gel-inducing composition and a powder preparation prepared according to each prescription,

And attaching the gel to the ceiling of the mouth of a pet by squeezing the gel with the fingers.

When the prepared powdered medicament is added in an amount of 5 to 40 parts by weight based on 100 parts by weight of the pet preparation medicament supplementing gel-inducing composition, the gel viscosity of the composition is sufficient to allow the powdered medicament to be adhered to the ceiling of a pet by floating with a finger . That is, through the gel preparations for pet preparation medicament supplementary assays which are prepared in advance with optimum viscosity, if the medicament prepared according to each prescription is powder afterwards, it can be provided as a gel type formulation by mixing alone.

The present invention provides a gel-derived composition which is molded into a viscous material having an appropriate viscosity while adding a vegetable oil to a base composition containing lactic acid bacteria and an enzyme and is packaged in a quantitative manner, so that when mixed with a powdered medicament prepared according to each prescription The entire mixture is attached to the ceiling of the pet mouth without spillage, and when the gel-inducing component is melted by the needles, the medicament is naturally absorbed.

The gel-inducing composition for pet medicines according to the present invention is a lactic acid bacterium of pet favorite taste, which reduces the feeling of rejection, enhances digestion and absorption by enzyme addition, and has a desired viscosity when mixed with a pharmaceutical powder mixture And can be provided as a customized formulation.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a photograph showing a gel formulation of a gel preparation-assisted composition for pet pharmaceutical preparation of the present invention. FIG.

The present invention relates to a composition containing two or more kinds of multiple lactic acid bacteria-containing groups selected from the group consisting of Bacillus subtilis, Enterococcus faecium, Lactobacillus acidophilus, Bifidobacterium longum and Bifidobacterium thermophilium, ≪ / RTI >

Wherein the composition comprises 5 to 20 parts by weight of a vegetable oil per 100 parts by weight of the base composition, and is molded into a viscous material.

Generally, lactic acid bacteria are also referred to as lactic acid bacteria . These bacteria are various bacteria that can ferment saccharides to obtain energy. Thus, the lactic acid bacteria used in the present invention may be selected from the group consisting of two or more lactic acid bacteria selected from the group consisting of Bacillus subtilis, Enterococcus faecium, Lactobacillus acidophilus, Bifidobacterium longum, and Bifidobacterium thermophilium , And more preferably the combination lactic acid bacteria comprising the above-mentioned five kinds.

The Bacillus subtilis bacterium contained in the complex lactic acid bacteria-containing group is a useful bacterium mainly used for fermentation of food. It inhibits the production of aprotoxin, which is a carcinogenic substance in the fermentation process. In particular, It has excellent efficacy.

In addition, Enterococcus faecium is an enterococcus which can be used as a health functional food and is known to be effective for the removal of heavy metals such as cadmium.

In general, the Lactobacillus family lives in the small intestine and has the effect of inhibiting harmful substances that secrete antimicrobial and immunological substances and cause constipation and diarrhea. In the present invention, Lactobacillus acidophilus is used in the present invention, and the intestinal tackiness and lactic acid secretion of lactic acid bacteria are excellent, and staphylococci and Salmonella are inhibited.

In addition, the Bifidobacterium family generally lives in the large intestine and inhibits Escherichia coli, promotes intestinal motility, alleviates allergic diseases, and suppresses enteropathogenic bacteria to reduce diarrhea, enteritis and irritable bowel syndrome.

Thus, the present invention uses Bifidobacterium longum and Bifidobacterium thermophilum .

Since each of the above-mentioned fungi exhibits different functions in the intestines, it is preferable that they are contained as complex lactic acid bacteria for overall physical health. This complex lactic acid bacterium is also a strong strain that can coexist with antibiotics at the usual dosage level. It maintains stability even at high bile salt concentration and acidic conditions such as gastric juice, and maintains stability even at high temperature pelletization temperature of 60 to 70 ° C do.

The enzyme in the base composition is an enzyme capable of hydrolyzing the food from a polymeric organic compound to a low molecular weight organic compound in the digestive tract of an animal, thereby obtaining energy. Protease , Alpha Amylase ), and dietary fiber in the cellulose-decomposing enzyme (containing Cellulase), lipase (lipase), and polysaccharides of pectin lyase (Pectinase).

The combined lactic acid bacteria and the enzyme together can provide a balance between in vivo degradation, digestion and toxin release, and in particular, can be administered to dogs or cats with mutant diarrhea or diarrhea, prevention of enteritis, weak aged dogs, have.

It is preferable that the performance of the base composition is comprised of 1 to 10% by weight of the complex lactic acid bacteria-containing group and 90 to 99% by weight of the enzyme-containing group with respect to the whole base composition. In the examples of the present invention, And 98% by weight of the enzyme-containing group. If the content of the complex lactic acid bacterium exceeds 10% by weight, even if it is consumed at a level exceeding the recommended intake, the functional property is not improved. If the excessive lactic acid bacteria is ingested, a certain amount of the strain may cause gas to cause diarrhea. .

The enzyme-containing group in the base composition of the present invention further contains, in addition to the enzyme, vegetable oil, chicken liver powder and additives.

The vegetable oil may be any known vegetable oil including canola oil, soybean oil, corn oil, grape seed oil, and brown rice oil.

Chicken liver powder is a good source of high quality protein, which is rich in vitamin A, vitamin B and especially vitamin B12, and contains trace elements such as iron, copper, zinc and chromium. , It can be stored for a long time in the form of lyophilized powder, and it is easy to use in all seasons.

Examples of the additive include a sugar (Dextrose monohydrate), an emulsifier, a preservative, an anti-caking agent and the like.

The gel-inducing composition for pet medicines according to the present invention is formed into a viscous material having an optimal viscosity by containing 5 to 20 parts by weight of vegetable oil per 100 parts by weight of the base composition, Lt; RTI ID = 0.0 > 5% < / RTI > to 10% of the standard daily food intake.

The vegetable oil may be selected in consideration of compatibility and miscibility between components of the gel-inducing type composition, and the same components as the oil component constituting the base composition are used. In the examples of the present invention, the oil component employed for controlling viscosity by using canola oil as the vegetable oil in the base composition is also described using canola oil, but the present invention is not limited thereto.

If the content of the vegetable oil is less than 5 parts by weight, the gel-derived composition for assisting the preparation of medicines for the preparation of medicines may become whitish and if the viscosity is too high, the preparation is difficult to mix because the preparation is not mixed. On the other hand, And thus the problem of difficulty in administration of appropriate pharmaceutical preparations occurs.

The above-mentioned viscous substance is mixed with the pet pharmaceutical preparation medicament-assisted gel-derived composition in the form of a powdered medicament prepared according to each prescription, the degree of entrapment of the whole mixture without leaving residues in the container without flowing out when the fingers are opened By weight.

Specifically, the optimum viscosity satisfies 700 cP or less, more preferably 550 to 700 cP, as a measurement standard at a rotational speed of 140 to 200 rpm using a rotary viscometer at a temperature of 25 캜.

In addition, the present invention relates to a method for preparing a gel preparation composition, comprising the steps of charging a pet pharmaceutical preparation medicament-assisted gel-inducing composition and a powder preparation prepared according to each prescription,

A method for administering a pet pharmaceutical preparation is provided by floating the gel with a finger and attaching the gel to the ceiling of a pet's mouth.

That is, the present invention relates to a composition for assisting the preparation of a pet preparation medicament, which is prepared by previously determining an optimal viscosity without mixing with each other when the components are mixed together, or when the medicament prepared according to each prescription is powder , And it can be provided as a gel type formulation by mixing alone.

Accordingly, the prepared powdered medicament can be provided as a custom gel type formulation having a desired viscosity when it is added in an amount of 5 to 40 parts by weight with respect to 100 parts by weight of the pet pharmaceutical preparation medicament supplementing gel-inducing composition have.

Hereinafter, the present invention will be described in more detail with reference to Examples.

The present invention is intended to more specifically illustrate the present invention, and the scope of the present invention is not limited to these embodiments.

≪ Example 1 >

Step 1: Preparation of base composition

2% by weight of the lactic acid bacteria-containing group and 98% by weight of the enzyme-containing group of the ingredients shown in the following Table 1 were prepared, respectively, and each was put into a container and mixed at 20 DEG C for 60 minutes. The base composition was then subjected to an aging step.

Step 2: Preparation of base composition

To 100 parts by weight of the base composition prepared in the above step 1, 5 parts by weight of canola oil was slowly mixed and mixed to prepare a gel-inductive composition.

≪ Example 2 ~ 3 >

A gel-derived composition was prepared in the same manner as in Example 1, except that 10 parts by weight and 20 parts by weight of canola oil were contained in 100 parts by weight of the base composition in the step 2 of Example 1 .

≪ Comparative Example 1 &

The procedure of Example 1 was repeated except that flour was added to the base composition in step 2 of Example 1 above.

≪ Comparative Example 2 &

A gel-inductive composition was prepared in the same manner as in Example 1, except that in Step 2 of Example 1, 100 parts by weight of the base composition contained 35 parts by weight of canola oil.

<Experimental Example 1> Viscosity Measurement

Viscosities of the compositions prepared in Examples 1 to 3 and Comparative Examples 1 and 2 were measured using a rotational viscometer (BROOKFIELD (USA), Model No. DV-II + Pro).

The spindle was immersed in the composition to be measured and the spindle was locked to the marked part. When the spindle is locked, the bubbles are not generated at a slight angle and it is common that the viscosity changes largely according to the temperature. Therefore, after the temperature stabilization, the viscosity is measured according to the following conditions.

1) Spindle No. 1; : LV-4 (64)

2) Rotational speed (rpm): 60, 100, 140, 200

3) Temperature of sample: 25 ° C

The results are shown in Table 2 .

For reference, the viscosity of water was 1.0 cP at 20.2 ° C, 0.8937 cP at 25 ° C, and the viscosity of honey was 2,000 to 10,000 cP depending on the temperature and type of honey.

From the results shown in the above Table 2, the compositions of Examples 1 to 3 exhibited viscosity of 700 cP (centi Poise, centipoise) or less based on the conditions of the rotational speed of 140 rpm and 200 rpm of the rotary viscometer at 25 ° C, And a viscosity of 550 to 700 cP. At this time, in the case of the composition having a viscosity out of the viscosity range, it was confirmed that the mixture did not remain in the container without flowing out when the finger was lifted, and the entire mixture was filled.

While the invention has been shown and described with reference to certain exemplary embodiments thereof, it will be understood by those skilled in the art that various changes and modifications may be made without departing from the spirit and scope of the invention as defined by the appended claims.

Claims (5)

Bacillus subtilis , Enterococcus faecium , Lactobacillus acidophilus , Bifidobacterium longum , and Bifidobacterium thermophilum ( Bifidobacterium thermophilum ), Bifidobacterium thermophilum ) And a group comprising an enzyme-containing group and at least one compound selected from the group consisting of
Wherein the composition is formulated into a viscous product by containing 5 to 20 parts by weight of a vegetable oil based on 100 parts by weight of the base composition. The gel-inducing composition for pet medicines according to claim 1, wherein the viscous material has a viscosity of 700 cP or less on the basis of a rotation speed of 140 to 200 rpm of a rotational viscometer at 25 캜. The composition of claim 1, wherein the gel-derived composition is provided in a stick package quantified as 5-10% of a standard daily food intake per pound of body weight of a pet. A method for preparing a gel-derived composition for pet medicines for medicines according to any one of claims 1 to 3, wherein the powdered medicament prepared in accordance with the prescription is added and mixed to form a gel,
And attaching the gel to the ceiling of the mouth of a pet by fingering the gel. 5. The method of claim 4, wherein the prepared powdered medicament is added in an amount of 5 to 40 parts by weight based on 100 parts by weight of the gel-inducing composition for pet medicines.

Images