KR20070041890A - Topical preparations for hair growth - Google Patents

Abstract

The present invention relates to a topical composition for promoting hair growth, and more specifically, 4-pyrrolidine 2,6-diaminopyrimidine 1-oxide together with white, vitamin B5 derivative (panthenol derivative), sugar extract (Swertiall), yiinin, licorice extract (glycyrrhizin and glycyrrhetic acid), nicotinamide (niacinamide), vitamin E derivatives (tocopherol acetate, etc.), adenosine, pentadecane glyceride (adenosine) glycerylpentadecanoate (PDG), benzylaminopurine, eugenol, eugenol, sawpalmetto, dialkylmonoamine derivatives, isoflavones, hinokitiol and benzyl By containing at least one member selected from the group consisting of nicotinic acid (benzylnicotinate), the nutrients necessary for hair growth are smoothly supplied through dilation of blood vessels around the hair follicles. Promote the induction period group and the hair, to a composition for external application for hair growth promoting hair growth cycle for the extended period.

Pyrrolidinyldiaminopyrimidine oxide, hair growth, composition, vasodilation

Description

Topical preparations for promoting hair growth

1 is a graph showing the effect of opening the potassium channel by pyrrolidinyldiaminopyrimidine oxide.

2 is a graph showing the effect of pyrrolidinyldiaminopyrimidine oxide to promote the proliferation of hair follicle papilla cells.

3 shows the effect of pyrrolidinyldiaminopyrimidine oxide promoting hair growth in mice.

The present invention relates to a topical composition for promoting hair growth, and more specifically, 4-pyrrolidine 2,6-diaminopyrimidine 1-oxide together with white, vitamin B5 derivative (panthenol derivative), sugar extract (Swertiall), yiinin, licorice extract (glycyrrhizin and glycyrrhetic acid), nicotinamide (niacinamide), vitamin E derivatives (tocopherol acetate, etc.), adenosine, pentadecane glyceride (adenosine) glycerylpentadecanoate (PDG), benzylaminopurine, eugenol, eugenol, sawpalmetto, dialkylmonoamine derivatives, isoflavones, hinokitiol and benzyl By containing at least one member selected from the group consisting of nicotinic acid (benzylnicotinate), the nutrients necessary for hair growth are smoothly supplied through dilation of blood vessels around the hair follicles. Promote the induction period group and the hair, to a composition for external application for hair growth promoting hair growth cycle for the extended period.

In the modern society that emphasizes beauty, various studies are being actively conducted around the world to treat hair loss and promote hair loss of men or women who suffer severe mental pain from genetic or environmental hair loss.

Human hair is about 100,000 to 150,000 pieces, each hair is repeated to grow and degenerate through different cycles. Hair is a growing period (Anagen), a degenerative period (Catagen) where metabolic processes slow down while maintaining the shape of the hair, and hair papilla atrophy, hair follicles atrophy gradually, hair roots are pushed upwards, and the hair follicles become smaller (Telogen) Repeat the three-step cycle of), and the hair cycle and lifespan can vary according to various conditions such as nutrition, medical history, heredity, constitution, hormone secretion or aging.

Among the existing anti-hair loss treatments, external minoxidil, approved by the US FDA, leads to the growth phase in the resting hair cycle and maintains the induced growth phase hair cycle in addition to its vasodilatation function as its unique potassium channel opener. Activity has been reported (British Journal of Dermatology. 2004; 150: 186-194).

In addition, an oral administration drug, Finasteride (Propecia; MSD), which inhibits the action of 5 alpha-reductase and inhibits the production of the active male hormone dihydrotestosterone, is marketed as a hair regrowth with the approval of the US FDA. However, there is a limit to use as the occurrence of expensive and side effects are reported. Thus, there has been a continuing need for drugs that are free of hair growth and side effects compared to the two major drugs previously developed.

The mechanism of hair growth effects of the pyrimidine derivative minoxidil (2,4-diamino-6 piperidino-pyrimidine-3-oxide) is still not clear, but only open the potassium channel at the time the drug was first developed. It is recognized as an effect by the expansion of blood vessels according to the effect.

Subsequently, there have been reports on the general potassium channel opening effect and hair growth effects for various pyrimidine derivatives and novel compounds (J Invest Dermatol 2005 124 (4): 686-94). Patents have been filed for hair growth (US Pat. Nos. 5,034,387 and 4,945,093). Previous patents on hair growth of pyrimidine oxide derivatives cover a broad range of inducible structures, including the structure of the minoxidil drug previously described, and the hair growth of each individual derivative is generally accepted. In addition, data on the mechanism of hair growth, such as vasodilation of minoxidil, are not attached.

Therefore, the inventors of the present invention, a pyrimidine linked compound at the carbon position 6 in the basic chemical structure of the pyrimidine oxide, which is listed as having the function of waving and straightening the hair of the international mid-term in the pyrimidine oxide derivative This potassium channel opening effect and the hair follicle cells in the hair follicle cells to control the hair cycle of hair follicles to promote the growth of the hair cells, and applied to the mouse to find the hair growth effect, pyrrolidinyl diaminopyrimidine oxide It acts antagonistically with potassium channel opening inhibitory drug to show potassium channel opening effect, promotes dermal papilla cell proliferation, and is applied to mice with resting hair cycle to promote the transition from resting phase to growing hair cycle. It confirmed and completed this invention.

Accordingly, it is an object of the present invention to provide a topical composition for suppressing general male type or female type hair loss and promoting hair growth by containing the pyrrolidinyldiaminopyrimidine oxide as an active ingredient.

In order to achieve the above object, the present invention provides a topical composition for promoting hair growth that promotes potassium channel opening and hair follicle cell proliferation by containing pyrrolidinyldiaminopyrimidine oxide as an active ingredient.

Hereinafter, the present invention will be described in more detail.

4-pyrrolidine 2,6-diaminopyrimidine1-oxide used in the present invention is represented by the following Chemical Formula 1 and belongs to a pyrimidine oxide derivative, The effect is unknown and is used as a cosmetic ingredient.

In the present invention, when pyrrolidinyldiaminopyrimidine oxide is used for the purpose of promoting hair growth, 0.001 to 10% by weight may be used based on the total weight of the composition, depending on the purpose and the formulation for external application, pyrrolidinyldiaminopyrimidine In view of the solubility of the oxide, it is preferable to solubilize or use an amount of 0.001 to 5% by weight for stability of the formulation. In general, when not solubilized in a certain formulation or there is a problem in stability, it may be agglomerated into a crystalline form or denatured may cause discoloration or odor.

In addition, the external preparation composition according to the present invention is a white porcelain, vitamin B5 derivative (panthenol derivative), glycoside with 4-pyrrolidine 2,6-diaminopyrimidine 1-oxide. Extracts (Swertiall), yiyiin, licorice extract (glycyrrhizin and glycyrrhetic acid), nicotinamide (niacinamide), vitamin E derivatives (tocopherol acetate, etc.), adenosine, pentadecane glycerides (glycerol pentadecanoate; PDG), benzylamino Group consisting of 6-benzylaminopurine, eugenol, saw palmetto, dialkylmonoamine derivatives, isoflavone, hinokitiol and benzylnicotinate It may contain one or more selected from, the content is preferably 0.005 to 5% by weight relative to the total weight of the composition.

Panthenol derivatives used in the present invention are usually derivatives of pantothenic acid, and pantothenic acid has been found to be an essential growth factor of yeast, and is stable in neutral solutions but destroyed in acidic or alkaline conditions, and has a particularly weak disadvantage in heat. Therefore, D-panthenol, D-ethylpanthenol or D-pantothenate calcium or salts were used as provitamins which are converted to vitamin B5 in a more stable structure. The effects of vitamin B5 are usually summarized as related to D-panthenol, where the multiple effects on skin and hair are usually reported by three factors: 1) the ability to penetrate the skin and hair relatively deep, 2 A) ability to bind water, 3) the conversion of pantothenic acid from skin and hair to produce the effects of vitamin B5. The addition of D-panthenol up to 0.1-5% in the cosmetics area delivers deep into the dermis due to its high permeability, and its hygroscopic capacity affects the state and distribution of moisture in the dermis layer, resulting in moisturizing action. Done. In 1943, H. Pfaltz indirectly confirmed that panthenol was absorbed and converted to pantothenic acid. After treatment with 10% D-panthenol in ointments for 6 weeks in rats and mice, hypopigmentation and Hair loss was reported to be treated higher (Pfaltz H., Vitaminforschung, 1943, 13, 236-249). In addition, reports have demonstrated the effect of panthenol on cutaneous epithelial cells in wound and burn healing (Gartner F., Dtsch. Zahnarztl. Z, 1955, 10, 813-5, Cortesse J., GM de France, 1968, 75,4171-4). When applied to the hair, panthenol penetrates the hair shaft and the hair root and exists as an elastic layer on the inner wall, and is surrounded by a thin layer on the outer wall to retain moisture in the hair and protect it from external drying. do.

Thujae semen is a seed of Thuja orientalis (occidentalis) from the oval, long oval or long columnar, 3 to 5 mm long, 2 to 3 mm in diameter. Baekjain has the efficacy of conscience and concubine (conscience of conscience) and yunjangtongpyeon (Yangjangtongpyeon). It is known to contain many fat oils. The hair piece of Dong Bo-gam is composed of the rich, man-shaped, and white porcelain, and its effect is known to bring back the missing mustache or hair, and the prescription is rich and pure berry. 20g each of his brother's (蔓 荊 子) and baekbaek seeds (baekjain; 柏子仁), put it in the oil of bone-black chicken oil, mix it, dry it, put it in a frying bowl, block it well, put it out for 100 days, and take it out. If you apply it for 3-5 days, a new hair comes out (Samsunggo, Namsan-dang). In addition, Baekjain showed 5α-reductase inhibitory activity, and its hair growth activity was high in two animal models, and it could be used as a useful material for alopecia by regulating androgen conversion (Journal of Dermatological Science) (2003) 31,91-98).

In addition, the medicinal extract is dissolved in the whole Swertiajaponica Makino herb, is called as senburi extract in Japan, is called medicinal herbs in Korea, and is called bitter grass of gentian. This extract is a native drug widely used in Japan for abdominal pain, skin infection, hookworm and cold. Common medicinal extracts include 2-4% of swetitiamarin, sertianolin, erythrocentaurin, swetitianol, oleanolic acid and genitianine. It consists of. The main component of the extract is known as glycoside including swetitiamarin and is usually derived from animals and plants. It can increase skin temperature and promote hair growth, such as cantharide and red pepper tincture. Is reported. It is caused by the physical effects of skin temperature rise or by vascular expansion of cholinergic drugs, and this trigger may promote blood flow for the function of the skin. In a paper by Shuji Iwao of the Fragrance Journal of Japan (1996), "About Prospects for Hair Growth Agents," sugar extracts were considered to be the main components of commercial hair growth agents as blood stimulators.

Other components that may be included in the present composition include lysine, licorice extract (glycyrrhizin and glycyrrhetic acid), nicotinamide (niacinamide), vitamin E derivatives (such as tocopherol acetate), adenosine, pentadecane glycerides (glycerylpentadecanoate; PDG), 6-benzyl aminopurine, eugenol, sawpalmetto, dialkylmonoamine derivatives, isoflavones, hinokitiol and benzyl nicotinic acid ( As long as benzylnicotinate) is a compounding ingredient, there is no particular limitation as long as there is no problem in terms of safety, and its mechanism of action is also not a problem. However, the above components are formulated as a function of vasodilatation and hair follicle activation of commercial hair restorers, and can be prepared by a known method as a commercially available raw material.

In the present invention, there is no particular limitation in formulating an external preparation composition containing pyrrolidinyldiaminopyrimidine oxide as an active ingredient, but hair tonic, scalft treatment, hair shampoo, hair cream, general ointment, softening lotion, nutrition It may be formulated as a lotion, eye cream, nutrition cream, massage cream, cleansing cream, cleansing foam or powder, and the like.

As listed above, pyrrolidinyldiaminopyrimidine oxide may be appropriately selected and used by those skilled in the art without difficulty for a hair growth promoting effect according to the vasodilation function.

Hereinafter, the configuration and effect of the present invention will be described in more detail with reference to Examples and Test Examples. However, these examples are only for illustrating the present invention, and the present invention is not limited only to these examples.

<Test Example 1> Potassium channel opening effect of pyrrolidinyldiaminopyrimidine oxide

5% fetal calf serum and 100 IU of penicillin G were added to DMEM medium without phenol red, and NIH3T3 cell line, a mouse-derived fibroblast, was transferred to a 24-well microtiter plate at 10,000 cells / well. Tobutbutamide, a potassium channel open antagonist, was added at a final concentration of 2.5 mM, and pyrrolidinyldiaminopyrimidine oxide (proderma, Italy) was added at a concentration of 1, 50 and 100 uM. The culture medium was diluted 100-fold and added thereto, and then incubated at 37 ° C. for 3 days. After incubation, 200 μl of a 0.2% MTT (3- [4,5-dimethylthiazol-2-yl] -2,5-diphenyltetrazolium bromide) solution was added to each well, followed by incubation at 37 ° C. for 3 hours. Formazane was dissolved in DMSO (Dimethylsulfoxide). The absorbance of the dissolved formazan was measured at 570 nm using a microplate reader. Pyrrolidinyldiaminopyrimidine oxide cancels the potassium channel opening antagonism of tolbutamide by concentration, and as a result, the results of promoting the proliferation of NIH3T3 are compared with the control 100 and the results are shown in FIG. 1. In the above control group is a group that does not contain toltamide, a potassium channel open antagonist, and the negative control group is treated with only tolbutamide. Referring to the results of FIG. 1, pyrrolidinyldiaminopyrimidine oxide did not show a growth promoting effect through the opening of the potassium channel to the control level, but a high growth promoting effect compared to the negative control group treated with tolbutamide only. Observation was possible.

<Test Example 2> Test for promoting the proliferation of dermal papillae cells among hair follicle cells

Rat-derived follicular papilla cells cultured in DMEM (Dulbecco's Modified Eagle's Media) containing 2% fetal bovine serum were dispensed to 96 cells / well in a 96-well microtiter plate, and a positive control group was used as a sample. After adding minoxidil and pyrrolidinyldiaminopyrimidine oxide at a concentration of 10 ug / ml, the white porcelain, vitamin B5 derivative (panthenol derivative), sugar extract (Swertiall), uiyiin, and licorice extract (glycyrrhizin and glycyrrhetic acid) were added. ), Nicotinamide (niacinamide), vitamin E derivatives (such as tocopherol acetate), adenosine (adenosine), glyceryl pentadecanoate (PDG), benzylaminopurine, eugenol, bovine Palmito (saw palmetto), dialkylmonoamine derivatives, isoflavones (isoflavones), hinokitiol and benzylnicotinate (benzylnicotinate) to the pyrrolidinyldiamino It was added and diluted to a concentration of 10ug / ml with a limiter Dean-oxide, which was then incubated at 37 ℃ temperature for 48 hours. After incubation, 50 μl of 0.2% MTT (3- [4,5-dimethylthiazol-2-yl] -2,5-diphenyltetrazolium bromide) solution was added to each well, followed by incubation at 37 ° C. for 4 hours. The resulting formazan was dissolved in DMSO (Dimethylsulfoxide). The absorbance of the dissolved formazan was measured at 570 nm using a microplate reader. The relative difference in absorbance of the experimental group containing pyrrolidinyldiaminopyrimidine oxide was measured as compared to the control treated with only DMSO solution, and the results are shown in Table 1 below.

Treatment group Treatment concentration Dermal papilla cell proliferation (%) DMSO treatment group 10 µg / ml 100 Minoxidil Treatment Group 10 µg / ml 120 Pyrrolidinyldiaminopyrimidine oxide 10 µg / ml 118 Pyrrolidinyldiaminopyrimidine oxide + white porcelain 10 μg / ml ea 124 Pyrrolidinyldiaminopyrimidine oxide + (D-panthenol) 10 μg / ml ea 145 Pyrrolidinyldiaminopyrimidine oxide + Sugar extract 10 μg / ml ea 135 Pyrrolidinyldiaminopyrimidine oxide + Euiin 10 μg / ml ea 130 Pyrrolidinyldiaminopyrimidine oxide + licorice extract 10 μg / ml ea 146 Pyrrolidinyldiaminopyrimidine oxide + nicotinic acid amide 10 μg / ml ea 138 Pyrrolidinyldiaminopyrimidine oxide + Tocopherol acetate 10 μg / ml ea 142 Pyrrolidinyldiaminopyrimidine oxide + adenosine 10 μg / ml ea 132 Pyrrolidinyldiaminopyrimidine oxide + pentadecaneglycerides 10 μg / ml ea 142 Pyrrolidinyldiaminopyrimidine oxide + benzylaminopurine 10 μg / ml ea 135 Pyrrolidinyldiaminopyrimidine oxide + eugenol 10 μg / ml ea 136 Pyrrolidinyldiaminopyrimidine oxide + Sopalmito 10 μg / ml ea 120 Pyrrolidinyldiaminopyrimidine oxide + polyalkyl monoamine 10 μg / ml ea 124 Pyrrolidinyldiaminopyrimidine oxide + isoflavones 10 μg / ml ea 142 Pyrrolidinyldiaminopyrimidine oxide + Hinokithiol 10 μg / ml ea 125 Pyrrolidinyldiaminopyrimidine oxide + benzylnicotinic acid 10 μg / ml ea 129

<Test Example 3> Effect of the hair growth field of pyrrolidinyldiaminopyrimidine oxide through the mouse

Pyrrolidinyldiaminopyrimidine oxide was dissolved in a negative control solvent composed of water / ethanol / 1,3-butylene glycol (5/3/2) to a concentration of 0.5% by weight, and then pyrrolidinyldiaminopyrimidine The hair growth effects of the oxides were tested.

47-53 days old mouse (C57BL / 6) to remove the dorsal hair, and the back skin is selected to clean the 8 dogs per material group to select the 1% pyrrolidinyl diaminopyrimidine oxide daily again white, Vitamin B5 derivatives (panthenol derivatives), sugar extracts (Swertiall), yiinin, licorice extract (glycyrrhizin and glycyrrhetic acid), nicotinamide (niacinamide), vitamin E derivatives (tocopherol acetate, etc.), adenosine, pentadecaneglycerides (glyceryl pentadecanoate (PDG), benzylaminopurine (6-benzylaminopurine), eugenol (eugenol), saw palmetto, dialkylmonoamine derivatives, isoflavones, hinokitiol And benzylnicotinate diluted with the pyrrolidinyldiaminopyrimidine oxide at a concentration of 1% and then added, and then 150 μl of each mouse group was applied for 21 days.

After 21 days, photographs of the degree of growth of the mouse hair were taken, and the weight of the newly grown hair was measured and compared with the negative control group, and the results are shown in Table 2. The general solution (water / ethanol / 1) as shown in Table 2 below. , 3-butylene glycol) showed an average value of about 29 mg higher than the group applied, and when applied together with 16 components that can be selectively used together with pyrrolidinyldiaminopyrimidine oxide in the present invention, pyrroly alone Higher hair growth could be observed than treated with dinylpaminopyrimidineoxide.

Treatment group Hair weight (mg) Negative Control 40 ± 18 Pyrrolidinyldiaminopyrimidine oxide 69 ± 12 Pyrrolidinyldiaminopyrimidine oxide + white porcelain 85 ± 8 Pyrrolidinyldiaminopyrimidine oxide + (D-panthenol) 87 ± 12 Pyrrolidinyldiaminopyrimidine oxide + sugar extract 88 ± 19 Pyrrolidinyldiaminopyrimidine oxide + 78 ± 10 Pyrrolidinyldiaminopyrimidineoxide + Licorice Extract 82 ± 16 Pyrrolidinyldiaminopyrimidine oxide + nicotinic acid amide 78 ± 8 Pyrrolidinyldiaminopyrimidine oxide + Tocopherol acetate 75 ± 10 Pyrrolidinyldiaminopyrimidine oxide + adenosine 88 ± 13 Pyrrolidinyldiaminopyrimidine oxide + pentadecaneglycerides 79 ± 12 Pyrrolidinyldiaminopyrimidine oxide + benzylaminopurine 75 ± 10 Pyrrolidinyldiaminopyrimidine oxide + eugenol 82 ± 17 Pyrrolidinyldiaminopyrimidine oxide + Sopalmito 73 ± 9 Pyrrolidinyldiaminopyrimidine oxide + polyalkyl monoamine 86 ± 12 Pyrrolidinyldiaminopyrimidine oxide + isoflavones 90 ± 12 Pyrrolidinyldiaminopyrimidine oxide + Hinokithiol 86 ± 11 Pyrrolidinyldiaminopyrimidine oxide + benzylnicotinic acid 89 ± 14

In the results of Table 2, it was confirmed that the pyrrolidinyldiaminopyrimidine oxide according to the present invention acts on the mouse of the resting hair cycle to promote the transition to the growing hair cycle, thereby promoting hair growth.

Hereinafter, based on the results of the above test example, various formulation examples are shown and presented. However, these formulation examples are intended to illustrate the present invention, and it is apparent to those skilled in the art that the formulation of the present invention is not limited to these formulation examples.

<Formulation Example 1> Hair Tonic

ingredient Weight ratio (%) ethanol 55 Castor Oil 5 glycerin 3 Pyrotonolamine 0.1 Pyrrolidinyldiaminopyrimidine oxide 1.0 White porcelain 1.0 Spices and Colors A reasonable amount Purified water Balance (to 100)

<Formulation Example 2> Hair Lotion

ingredient Weight ratio (%) Cetostearyl alcohol 2.0 Stearyl Triethyl Ammonium Chloride 2.0 Hydroxyethyl cellulose 0.5 Pyrotonolamine 0.1 Pyrrolidinyldiaminopyrimidine oxide 1.0 Righteous 1.0 Spices and Colors A reasonable amount Purified water Balance (to 100)

<Formulation Example 3> Hair Nourishing Creme

ingredient Weight ratio (%) Beeswax 4.0 Polysorbate 60 1.5 Sorbitan sesquioleate 0.7 Liquid paraffin 5.0 Squalane 5.0 Caprylic / Capric Triglycerides 5.0 glycerin 3.0 Butylene glycol 3.0 Propylene glycol 3.0 Carboxy Vinyl Polymer 0.1 Triethanolamine 0.2 Pyrrolidinyldiaminopyrimidine oxide 0.5 Sugar extract 0.5 antiseptic A reasonable amount Spices and Colors A reasonable amount Purified water Balance (to 100)

<Formulation example 4> Softening lotion (skin lotion)

Ingredient weight% Purified water Balance (To 100) Pyrrolidinyldiaminopyrimidine oxide 0.1 Pentadecaneglycerides 0.1 Butylene glycol 2.0 Propylene glycol 2.0 Carboxy Vinyl Polymer 0.1 Fiji-12 nonylphenyl ether 0.2 Polysorbate 80 0.4 ethanol 10.0 Triethanolamine 0.1 Preservatives, Colors and Flavors Quantity

<Formulation Example 5> Nourishing Cosmetic Water (Milk Lotion)

Ingredient weight% Purified water Balance (To 100) Pyrrolidinyldiaminopyrimidine oxide 0.1 Nicotinic acid amide 0.1 Beeswax 4.0 Polysorbate 60 1.5 Sorbitan sesquioleate 1.5 Liquid paraffin 0.5 Caprylic / Capric Triglycerides 5.0 glycerin 3.0 Butylene glycol 3.0 Propylene glycol 3.0 Carboxy Vinyl Polymer 0.1 Triethanolamine 0.2 Preservatives, Colors and Flavors Quantity

<Formulation Example 6> Nutrition Cream

Ingredient weight% Purified water Balance (To 100) Pyrrolidinyldiaminopyrimidine oxide 0.1 Licorice Extract 0.1 Beeswax 10.0 Polysorbate 60 1.5 Sebum 60 Cured Castor Oil 2.0 Sorbitan sesquioleate 0.5 Liquid paraffin 10.0 Squalane 5.0 Caprylic / Capric Triglycerides 5.0 glycerin 5.0 Putylene glycol 3.0 Propylene glycol 3.0 Triethanolamine 0.2 Preservatives, Colors and Flavors Quantity

Formulation Example 7 Massage Cream

Ingredient weight% Purified water Balance (To 100) Pyrrolidinyldiaminopyrimidine oxide 0.1 Isoflavones 0.1 Beeswax 10.0 Polysorbate 60 1.5 Sebum 60 Cured Castor Oil 2.0 Sorbitan sesquioleate 0.8 Liquid paraffin 40.0 Squalane 5.0 Caprylic / Capric Triglycerides 4.0 glycerin 5.0 Butylene glycol 3.0 Propylene glycol 3.0 Triethanolamine 0.2 Preservatives, Colors and Flavors Quantity

<Formulation Example 8> Pack

Ingredient weight% Purified water Balance (To 100) Pyrrolidinyldiaminopyrimidine oxide 0.1 Hinoki Thiol 0.1 Polyvinyl alcohol 13.0 Sodium Carboxymethyl Cellulose 0.2 glycerin 5.0 Allantoin 0.1 ethanol 6.0 Pingzi-12 nonylphenyl ether 0.3 Polysorbate 60 0.3 Preservatives, Colors and Flavors Quantity

As described above, pyrrolidinyldiaminopyrimidine oxide according to the present invention served to promote hair growth as an active ingredient of the external preparation for scalp. Therefore, the external preparation composition according to the present invention may have an effect of preventing hair loss and promoting hair growth through the potassium channel opening effect by containing pyrrolidinyldiaminopyrimidine oxide as an active ingredient.

Claims (6)

Vitamin B5 derivative (panthenol derivative), sugar extract (Swertiall), uiyiin, licorice extract (white) to 4-pyrrolidine 2,6-diaminopyrimidine 1-oxide glycyrrhizin and glycyrrhetic acid, nicotinamide (niacinamide), vitamin E derivatives (tocopherol acetate), adenosine (adenosine), pentyldecaneglyceride (PDG), benzylaminopurine (6-benzyl aminopurine), eugenol ), Sawpalmetto, dialkylmonoamine derivatives, isoflavones, isoflavones, hinokitiol, and benzylnicotinate further contain one or more selected as active ingredients External preparation composition for preventing hair loss or promoting hair growth. The composition of claim 1, wherein the 4-pyrrolidine 2,6-diaminopyrimidine 1-oxide is for opening potassium channels at the intracellular level. According to claim 1, wherein the composition is an external composition for promoting the proliferation of hair follicle cells. The composition for external preparation according to claim 1, which contains 0.001 to 10% by weight of pyrrolidinyldiaminopyrimidine oxide based on the total weight of the composition. According to claim 1, Vitamin B5 derivative (panthenol derivative), sugar extract (Swertiall), lysine, licorice extract (glycyrrhizin and glycyrrhetic acid), nicotinamide (niacinamide), vitamin E derivative which is white to the total weight of the composition (Tocopherol acetate), adenosine (adenosine), pentadecane glyceride (glycerylpentadecanoate (PDG), benzylaminopurine, eugenol, eugenol, sawpalmetto, dialkylmonoamine derivatives , Isoflavone (hinflaviti), hinokitiol (hinokitiol) and benzylnicotinate (benzylnicotinate) at least one member selected from the group consisting of 0.005 to 5% by weight. According to claim 1, wherein the composition is composed of hair tonic, scalp treatment, hair shampoo, hair cream, general ointment, softening longevity, nourishing longevity, eye cream, nutrition cream, massage cream, cleansing cream, cleansing foam and powder External composition, characterized in that selected from.

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