KR20060009472A - Systems with water-activated battery - Google Patents

Abstract

The present invention relates to a system for testing biological information such as DNA, and more particularly, to a system using a battery suitable for MEMS (Micro Electro Mechanical Systems), nano systems, and bio systems. The system according to the invention is characterized in that the battery is operated by an aqueous solution, such as water, blood or urine, administered as needed, and the electrical energy from the battery is supplied to other parts of the system to perform the desired function. According to the present invention, when an aqueous solution such as a test liquid containing DNA, as well as an aqueous solution obtained directly from the body such as blood, urine or body fluid extracted or excreted from each part of the body is brought into contact with the system according to the present invention, the water contained in the aqueous solution is A part flows into the battery to operate the battery, and the rest of the aqueous solution flows to the DNA chip or biosensor for testing, and the test is performed using electricity generated from the battery. The application field according to the present invention is applicable to any system for obtaining energy in an environment in contact with water as well as a disposable diagnostic device, a DNA chip (or microarray), a lab on a chip in medicine.

Biosystem, DNA Chip, Microarray, Biosensor, Battery, Water-activated Battery, Disposable Diagnostic Device, Disposable Diagnostic Reagent, Diagnostic Kit, MEMS, Nanosystem.

Description

Systems with Water-Activated Battery

1 is a block diagram of a system according to the present invention.

2 is a cross-sectional view of FIG.

3 is a block diagram showing a DNA chip portion of FIG.

4 is a block diagram showing the battery portion of FIG.

5 is a signal flow diagram in the system of FIG.

6 to 11 are embodiments with needles for liquid injection in a system according to the invention.

12 is an embodiment of a system with two needles for liquid extraction and drug administration in accordance with the present invention.

Figure 13 is an embodiment of a disposable diagnostic device for the test according to the present invention.

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a system having a battery, and more particularly to a system using a battery in which operation is started using water suitable for MEMS (Micro Electro Mechanical Systems), nano systems, and bio systems.

Recently, a lot of Micro Electro Mechanical Systems (MEMS), BioMEMS, Nanosystems, and diagnostic devices, also called micromachines, have been created, and many research institutes are investing in these technologies that will play a big role in the future. Many countries, including the United States, Japan, and Korea, support the technology nationally. Thanks to these efforts, there are many studies in this field. Examples include DNA chips, diagnostic devices, and micro transceivers. These products are mainly made up of Bulk Micromachining Technology, which manufactures silicon substrates directly, and Surface Micromachining Technology, which stacks and processes thin films on the substrate. These products have the advantage that the circuits of actuators, sensors, etc. can be made micro-sized on the board, which greatly increases the performance and makes the price very low. Lab on a chip, for example, puts a lot of experimental equipment on a piece of silicon, allowing multiple tests to be done simultaneously with a drop of liquid. A DNA chip that can test DNA by this technique is a DNA chip. This technology will become a core technology of the future by matching with future technologies such as Nano Technology in the future.

Such MEMS and Nano / Bio related technologies have the advantage that many mechanical parts and electronic parts can be manufactured on a substrate such as silicon at the same time. However, current technology has a problem of requiring an external energy source. For example, when a micro transceiver was made on a silicon chip having a width and height of 1 mm x mm, the existing large power supply or a battery was used. In addition, according to the current DNA Chip (or Micro Array) technology, when the DNA aqueous solution required for the test is dropped on the DNA chip in which the probe DNA is placed on the substrate, the DNA in the aqueous solution and the probe DNA are combined ( Hybridization). This binding includes information about the abnormality of DNA, and in order to analyze it, information is read using light such as ultraviolet rays. Such an analysis requires an information input device called a scanner, a computer, and software suitable for the purpose, so that the analysis takes a long time, the cost of the analysis is high, and an expert having a professional skill such as a doctor is required.

The present invention is to eliminate a number of inconveniences and problems described above, the battery is operated by an aqueous solution such as water, blood or urine administered when the operation of the system according to the present invention, the electrical energy from the battery Is supplied to other parts of the system to perform the desired function. According to the present invention, when an aqueous solution such as a test liquid containing DNA, as well as an aqueous solution obtained directly from the body such as blood, urine or body fluid extracted or excreted from each part of the body is brought into contact with the system according to the present invention, the water contained in the aqueous solution is Some can flow into the battery to operate the battery, and the remainder of the aqueous solution flows to a DNA chip or biosensor for testing and can be tested using electricity generated from the battery.

In order to achieve the above object, the invention is constructed as follows.

A substrate; Located on a portion of the substrate and can be started by water

An energy generator; Located in a portion of the substrate and consists of an energy consuming portion that consumes energy; When the liquid containing water comes into contact with the energy generating unit, the energy generating unit starts to generate electrical energy, and supplies the electrical energy to the energy consuming unit to consume energy at the energy consuming unit. It provides a system characterized in that.

In addition to the above configuration, the following, alone or in combination, may yield more desirable results.

The energy generating part and the energy dissipating part have a structure connected by a flow path so that the liquid can easily flow to a desired position.

System characterized in that.

The energy dissipation unit analyzes a liquid comprising a substance extracted from a human body.

The energy consuming part is a chip (or microarray) for analyzing at least one of DNA, RNA or protein.

system.

The energy dissipation unit is an analytical device for analyzing some or all of the components of the blood.                     

The energy dissipation unit is an analytical device for analyzing some or all of the components of urine.

-The energy consumption unit analyzes at least one of blood, saliva, runny nose, urine, vaginal discharge, serving, body fluids, DNA, RNA, protein, tissue and plant sap, DNA, RNA, tissue of the animal System.

-The energy consumption unit transmits information to the outside

Or at least one of receiving.

-The energy consumption part is voice information, image information, data

It is a communication device for transmitting and receiving at least one or more of the information, such as

System.

-The energy consumption part shows voice information and image information

A system characterized by being a television that is affordable.

-The energy consumption part can receive only voice information

The system characterized in that the radio.

-The energy generator is started by water

System characterized in that the battery.

-The aqueous solution containing the above water is

Batteries contain porous materials, such as space or paper, for good transport

System having a.

The battery described above contains magnesium and cathode at the anode.                     

Silver chloride (AgCl) or copper chloride (CuCul) is used for the cathode, and the above water is

When it comes into contact with the containing liquid, the operation starts and generates electrical energy.

Key system.

The liquid is moved to a predetermined position by surface tension when the liquid comes into contact with the energy generating part and the energy consuming part.

A liquid inlet connected to said flow path for easy receipt of said liquid.

The liquid inlet part is a hole.

The liquid inlet part is a needle.

Said needle having a stopper so that the needle can stick to a defined depth when sticking to the skin.

A device for holding the needle in a position facing the needle, in order to prevent the needle from sticking to the skin when the needle is punctured and withdrawn from the skin.

The needle and the device for holding the needle utilize the engagement of a gear.

The needle destroys the rupture means when the needle is pierced in the desired area.

The bursting means is a membrane.

When the needle is pierced in a desired area, the system has a material which is used as a rupture means to react with the components of the liquid or to dissolve in the liquid component.

A relatively low pressure side of the system relative to the bursting means so that the liquid flows well into the system.

-The system characterized in that it has a drug holding unit having the necessary medicine according to the above analysis results.

A system in which said medicine is injected automatically via a needle or manually if necessary.

A diagnosis unit for analyzing the information of the desired living body, a display unit for displaying the result of diagnosis in the diagnosis unit, an input unit for selecting or inputting a required diagnosis, and a memory unit for storing necessary information And a combination of a transmission unit capable of transmitting or receiving the processed signal to the outside, if necessary, and a control unit capable of adjusting or instructing the movement of each unit described above to perform a desired diagnosis.

The transmitting part is a waveguide such as a conductor or an optical cable

System for transmitting and receiving signals by wire using a furnace.

-The above-mentioned transceiver is laser, visible light, ultraviolet ray, infrared ray

Electric waves, including radio waves of frequencies of a degree used for wires, radio or television

Send and receive signals wirelessly using sound waves, including magnetic waves and ultrasonic waves                     

System characterized.

Another preferred system configuration is as follows.

A substrate; At least one electrode positioned on the substrate and capable of applying a voltage; Accept an aqueous solution containing a chargeable material on the electrode

And the space (Chamber); A permeation layer formed on the electrode to avoid direct electrical contact between the aqueous solution and the electrode; In the case where the aqueous solution flows into the space, the sensing part can detect whether or not the charged material is attached to the permeable layer when the charged material is attached to the permeable layer. By applying a voltage to the electrode, an electric field is formed around the electrode to cause the charged material in the aqueous solution to adhere to the permeable layer on the electrode. It provides a system characterized by detecting whether or not in one of the aqueous solution.

In addition to the above configuration, the following may be performed alone or in parallel to obtain more desirable results.

A corresponding electrode is placed in a position maintaining a predetermined distance while facing the electrode in order to easily form an electric field in the electrode.

Placing a biological probe such as DNA or RNA on the permeable layer formed on the electrode in advance, and when the hybridization occurs due to the biological material in the aqueous solution, the detection unit A system characterized by detecting the presence of binding.                     

A battery having a battery which starts operation using an aqueous solution containing water when electrical energy is required, such as by forming the electric field and detecting it by the sensing unit.

Blood, saliva, runny nose,

A system characterized by using an aqueous solution containing biological samples, such as body fluids and plant tissues, which can be drained or extracted from an animal body such as urine, vaginal secretions, phosphorus, and cellular tissues.

-Charged water in the aqueous solution described above

When the vagina is attached to the transmission layer on the electrode, the impedance change is carried out using the impedance change including a sensor for sensing at least one of impedance components of capacitance, resistance, and inductance. And a sensing unit for sensing the attachment of a charged material on one transmission layer.

-When the charged material in the aqueous solution is attached to the transmission layer on the electrode while taking a material having a magnetic field, such as a small magnet, by detecting a change in the magnetic field, such as a Hall sensor And a detector configured to detect attachment of a charged material to the transmission layer.

-When a charged material is attached to the above-mentioned transmission layer, the electromagnetic wave such as laser, visible light, ultraviolet ray, infrared ray, radio wave is irradiated to the portion to which the charged material is attached, and the reflection transmission characteristic of the electromagnetic wave is And a sensing unit for detecting whether the above-mentioned charged substance is attached.                     

-When a charged material is attached to the above-mentioned transmission layer, the sound wave including ultrasonic waves is irradiated to the portion to which the charged material is attached, and the above-mentioned charge is transmitted using the reflection transmission characteristics of the sound wave. The strip comprises a detector for detecting whether a substance is attached.

-In order to increase or decrease the reflection transmission characteristics of the electromagnetic wave and the ultrasonic wave, a system for changing the reflection transmission characteristics to the charged material.

Another preferred embodiment according to the present invention is configured as follows.

A substrate; An energy generating unit located on a portion of the substrate and capable of starting operation by water in an aqueous solution containing a substance to be detected or inspected; Located in a portion of the substrate and consumes energy, consisting of an energy consumption unit for detecting how much the material to be contained in the aqueous solution contained; When the aqueous solution flows in, energy is generated in the energy generating unit by water in the aqueous solution, and detecting or inspecting a substance contained in the aqueous solution while using the energy in the energy consuming unit. It provides a system characterized by.

Hereinafter, exemplary embodiments of the present invention will be described with reference to the accompanying drawings.

1 to 5 show a representative embodiment of the system according to the present invention, showing a disposable DNA Chip (Micro array) for electrically testing DNA. As shown in FIG. 1, a system 100 having a battery operated by a liquid mainly consists of an upper plate 101 having an energy consumption portion and a lower plate 102 supplying energy generated from the battery. The upper plate 101 may be made of a transparent material for convenience. The upper plate 101 includes a DNA sensor unit 103 capable of electrically inspecting DNA, a hole 104 for accepting an aqueous solution (not shown) containing DNA in the DNA sensor unit 103 and a battery to be described later, and the hole 104 described above. And Euro 109 connecting the DNA sensor 103, the display unit 107 having a number or a letter display device 108 to display the results after the DNA test, select the required test of the DNA test or input the necessary information It consists of an input unit 105 consisting of at least one button 106. FIG. 1 is three-dimensionally drawn to easily show the appearance of the system according to the present invention. The cross section, the DNA sensor unit, and the battery unit of the system will be described in detail with reference to FIGS. 2, 3, and 4, respectively. . 2 shows the DNA sensor unit 103 and the battery unit 122 in the cross section of the system. The hole 104 is for receiving an aqueous solution (not shown) containing DNA, and the hole 104 is connected to each other by the channels 109 and 121 in the DNA sensor unit 103 and the battery unit 122. The detailed operation principle of the DNA sensor unit 103 and the battery unit 122 will be described in detail with reference to FIGS. 3 and 4, and an aqueous solution (not shown) containing DNA is formed in the hole 104 described above with reference to FIGS. Show how the entire system works when injected.

When the above-described aqueous solution containing DNA is dropped into the hole 104, the aqueous solution moves to the DNA sensor unit 103 and the battery unit 122 through the flow paths 109 and 121 by the surface tension of water. The water in the aqueous solution moved to the battery unit 122 generates electric energy by operating the battery unit 122 operated by water, and the generated electric energy is the DNA sensor mentioned in FIG. 2 through a connecting line (not shown). The input portion 105 and the display portion 107 mentioned in the section 103 and FIG.

In the DNA sensor unit mentioned in FIG. 2, any sensor for analyzing DNA may be placed. Here, as an example, a DNA sensor unit for electrically detecting DNA as shown in FIG. 3 is used as an example of the DNA sensor unit according to the present invention. 3 is an example of a DNA sensor unit according to the present invention. DNA can be easily tested using the electrical energy generated by the battery 122 described above. The DNA unit 103 has a space (or flow path) 120 between the lower plate 131 and the upper electrode 137 and the lower plate 131 and the upper electrode 137 so that the aqueous solution can be easily introduced through the flow path 109. The lower plate 131 has one or more electrodes 132, 133, and 134, and a plurality of insulators 135 are provided between the electrodes to insulate the electrodes, and the electrode and the insulating layer are formed of a porous material such as agarose. There is a Permeation Layer 136. In the transmissive layer on the electrodes 132, 133, and 134, fragments (not shown) of DNA to be detected are attached in various ways as necessary. For the sake of convenience, the DNA principle (DNA probe) is attached to the transmission layer on the electrode of 133, and the principle of operation will be described.

The mechanism for electrically detecting DNA will be described with reference to FIG. 3. As mentioned in the description of FIG. 2, when an aqueous solution containing DNA (not shown) fills the space 120 of FIG. Many negatively charged DNA fragments are distributed. The DNA fragment attached to the permeable layer on the electrode 133 is a DNA probe related to a specific disease, and it will be described on the assumption that there is a DNA fragment that can be hybridized with the DNA probe in the aqueous solution. When a negative voltage is applied to the upper electrode 137 and a positive voltage is applied to the electrode 133, the DNA fragments negatively charged in the aqueous solution move toward the electrode 133 and come into contact with the transmission layer. In this case, if the DNA fragment is capable of binding to the DNA probe placed on the transmission layer on the electrode 133, the DNA fragment and the DNA probe are bound. The same phenomenon occurs with other DNA probes located on the other electrodes 132 and 134 described above. As such, when the DNA probe and the DNA fragment in the receptor are bound on the electrode of the desired portion, the presence or absence of the binding can be determined by electrically checking whether the DNA fragment is bound or not.

Whether the DNA probe and the DNA fragment in the receptor are combined is a sensor that detects changes in capacitance, resistance, and inductance before and after binding, or a magnetic field sensor that detects a change in the magnetic field, Or it detects changes before and after coupling using electromagnetic waves such as light and acoustic waves such as sound. The circuit between the electrode 133 and the upper electrode 137 can be modeled as an equivalent circuit (Equvilaent Circiut) using one or more inductance (L), capacitance (C), resistance (R), the equivalent circuit before and after coupling The change in inductance, capacitance, and resistance indicates whether the DNA fragment in the aqueous solution adhered to the DNA probe in the transmission layer on the electrode 133. For example, if the capacitance C after coupling changes significantly, it can be obtained by using a capacitance sensor to measure this capacitance. A simple example of implementing a capacitive sensor is to connect an arbitrary resistor (R) to the electrode 133 and apply an AC voltage to the RC circuit constituted by the capacitance C. As the AC current changes according to the change of impedance, it is possible to know the coupling status. In order to prevent the negative charge DNA in the aqueous solution from further adhering to the permeable layer on the electrode 133, the electrode 133 is made a negative voltage, and the above-mentioned 137 is made a positive voltage. By applying a bias voltage in series with the AC voltage described above, it is possible to prevent the capacitance from changing during the inspection. When a small magnetic material (not shown) is attached to the DNA fragments in the aqueous solution, the bound DNAs become magnetic on the transmission layer located on the electrode 133. If a magnetic field sensor located in the vicinity of the electrode 133 is placed in order to detect the change in the magnetic field, the presence or absence of the coupling may be known using the magnetic field sensor. For example, if a Hall sensor, which is a kind of sensor for detecting a magnetic field, is placed under the electrode 133, the coupling may be immediately known from the change in the magnetic field. The presence or absence of the binding of the DNA may be examined using electromagnetic waves such as light. When the upper plate 137 is a transparent electrode and the DNA bound on the transmission layer on the electrode 133 has a fluorescent material, the presence or absence of binding by the light emission of the fluorescent material is irradiated with ultraviolet light, which is a kind of light through the upper plate 137 Get to know The presence or absence of the coupling can also be known from the ratio reflected or transmitted by irradiating electromagnetic waves, such as RF (Radio Frequency) bands, which are relatively low frequency. Acoustic waves, such as sound, can also be used to check for coupling. When ultrasound is irradiated to the bound DNA in the transmission layer on the electrode 133, the presence or absence of DNA binding can be known from the difference in the reflection or transmission characteristics of the ultrasound.

Reference is made to battery 122 which generates power using water as an electrical energy source in the system described in FIG. Any conventional battery that generates power in contact with water can be used with the battery 122 described above. For convenience, a battery having a structure as shown in FIG. 4 will be briefly described for convenience. The battery 122 has a magnesium layer 144 as an anode on the upper plate 145, a metal layer (such as copper or chromium / gold layer) 142 which collects electrons in order on the lower plate 141 and a cathode on the metal layer. The silver chloride (AgCl) or copper chloride (CuCl) 143 is deposited or coated, and there is a space 146 between the magnesium 144 and the silver chloride (or copper chloride) 143. For convenience, explanation will be made using a case where silver chloride is used as the cathode. When the aqueous solution containing DNA is injected as described in FIG. 2, the aqueous solution is pushed through the passage 121 in FIG. 2 into the space 146 in FIG. 4 by surface tension, and the water in the aqueous solution is magnesium 144 and chloride come in contact with 143 to produce the following electrochemical reactions.

Mg + 2AgCl-> MgCl ₂ + 2Ag (Formula 1)

As a result of this chemical reaction, magnesium 144 is oxidized to generate electrons (not shown), which electrons pass through a circuit (not shown) connected to the battery, and electrons are supplied to silver chloride 143 via the metal layer 142. In this process, the battery 122 supplies electric energy to the outside. The space 146 may be left empty or filled with a porous material such as paper.

FIG. 5 is a signal flow diagram showing the signal flow in the system operated by the water described in FIG. 1 and FIG. Diagnosis unit 501 (described in FIG. 1 as a DNA sensor), energy supply unit 503, display unit 506, and input unit 507 in the signal flow diagram of FIG. 5 are those mentioned in FIG. 1 or FIG. The controller 505, the memory 502, and the transmitter 504 have not been shown in FIG. 1 or 2 for the sake of brevity. FIG. 5 is an embodiment showing the system referred to in FIG. 1 and FIG. 2 in order to operate well as a whole. The essential part of the diagnosis part 501 and the energy supply part 503 must be present. The rest part may or may not be necessary. That is, if the system shown in FIG. 1 has already been determined to only perform a predetermined inspection, the input unit 507 is not necessary. In this case, the input unit 105 and the input button 106 do not have to be shown in FIG. 5 illustrates the flow of signals during operation of the system shown in FIGS. 1 and 2. As shown in FIG. 1, the flow of signals will be described using an example in which an aqueous solution containing DNA is introduced into the hole 104 that receives the aqueous solution. In the energy supply unit 503 described with reference to the battery unit 122 in FIG. 2, electrical energy is generated to activate each unit shown in FIG. 5. Therefore, the diagnostic unit 501 described as the DNA sensor examines the DNA in the DNA aqueous solution and sends the result to the control unit 505, and operates the display unit 506 so that the test result can be easily known when necessary. The memory unit 502 is used to control the control unit or to restore the data storage, which operation is specifically performed at the time of a complex inspection, and any one capable of storing data such as a hard disk semiconductor memory can be used, and the input unit 507 is the above-mentioned controller. It is a device for controlling a 505 or for instructing a specific operation to another part such as the memory unit and inputting a signal such as a keyboard or a button. The control unit 505 controls the signal transmission of each unit and specifies in detail what to do. The transmitter 504 may use a wired or wireless method as a part for transmitting a signal to send a test result from the controller to an external computer or a recording device. Wires may use conductive wires such as copper wires or waveguides that guide light or electromagnetic waves, such as optical cables. In the case of wireless, electromagnetic waves in the form of lasers, radio waves, infrared rays, ultraviolet rays, and visible light may be used, and in another form, sound waves such as ultrasonic waves may be used. In Fig. 5 showing the signal flow inside the system, the signal of each part is mainly transmitted by an electrical connection, but any method of signal transmission capable of transmitting energy is available. That is, the signal of each part can transmit a signal by using the flow of electrons through a conductive wire, an electromagnetic wave including a laser, a radio wave, an infrared ray, and an ultraviolet ray, or a sound wave such as an ultrasonic wave.

1 and 5 are examples of a system operated by using water, wherein an aqueous solution having DNA fragments is used to obtain the electrical energy required by the system from a battery, and the DNA is supplied to the respective parts by supplying the electrical energy. The diagnostic apparatus for inspecting was described. 6 shows another embodiment of the present invention as another system according to the present invention showing a diagnostic device operated by blood extracted from a human body. The diagnostic system 600 which develops by using blood and examines the blood is inserted into the biosensor 606 described above by the surface tension of the biosensor 606 for the blood test and the needle 603 for the blood injection. There is an air hole 604 through which the air inside the biosensor 606 can escape and a display unit 605 to display the result when the required inspection is completed. The back side 602 of the substrate generates power by the aforementioned water. It consists of a battery. Inside the diagnostic system 600 are the electrical circuits needed to smooth out the desired tests of the signal flow diagram shown in FIG. In this case, therefore, only the diagnosis unit, the display unit, the control unit, and the energy supply unit are included in the signal flow chart of FIG. 5.

Referring to FIG. 6, the operation principle will be described in the case of generating electricity by using blood and inspecting the required blood using the generated electricity. When the needle 603 of the diagnostic system 600 which checks blood is inserted into the skin (not shown), the surface tension of the blood causes blood to flow along the needle 603 along the flow path of the battery (not shown) and the biosensor 606 in the back 602 of the substrate. do. At this time, electricity is generated from the battery by the water in the battery, and the electricity is supplied to each of the necessary parts along an appropriate electric wire (not shown). Part of the blood flows along the flow path of the biosensor 606, and the inspection is performed by a sensor (not shown) disposed in part or all of the flow path, and the processing result is displayed on the display unit 605. Gases such as air in the biosensor 606 are discharged to the outside through the air holes 604.

7 to 11 illustrate an example in which an injection needle 702 is attached to a diagnosis unit (including a battery unit) 701 in order to easily introduce blood in the embodiment of FIG. 6. The 703 is not required as a stopper, but is installed to allow the needle to penetrate the skin to a certain depth. The diagnostic unit 701 has a space 708 therein, has a diagnostic means (including a battery) 709 in contact with the space 708, a needle 702 is positioned on one side of the diagnostic unit, and a stopper 703 is fixed on the needle 702. The needle 702 is connected to the stopper 706 by a guide 704, the stopper having a passage 705 through which the needle can be guided, and at the end of the stopper 706 there is a rupture means 707. The inner space 708 may be maintained at a vacuum lower than the atmospheric pressure or at an atmospheric pressure, but keeping the vacuum may be convenient and shorten the time for extracting blood.

The description of the above embodiment will be described taking only the blood of the patient as an example for convenience. The subsequent examination after extraction of blood is the same as described using FIG. This section only describes the extraction of blood from the skin. First, when the needle 702 is inserted into the patient's skin (not shown), the skin is caught by the stopper 703, and the needle 702 moves inward along the guide 704 and the passage 705, thereby piercing the rupture means 707. In this case, the blood in the human body moves on the needle 702 by the pressure difference between the blood pressure in the body and the internal space 708 to supply the blood 710 to the diagnostic means (including the battery) 709. In the diagnosis unit 701 having such a configuration, the needle 702 may adhere to the skin and be uncomfortable when the injection scale 702 is removed after the blood is extracted. In order to solve this problem, FIG. 10 is a detail of the part including the needle in FIG. When the needle 1001 pierces the skin (not shown), the needle 1001 moves in the direction of the arrow 1005 on the right side. At this time, the teeth 1002 and 1003 meshed with each other prevent the needle 1001 moved to the right from moving to the left again. Reference numeral 1004 denotes a support of the tooth 1003.

FIG. 11 shows a needle having another means for rupturing as shown in FIG. 8 as another embodiment according to the present invention, characterized in that the needle 1101 has a rupture means 1102. The needle 1101 has a rupture means 1102 that is a dissolved substance therein and is fixed to the stopper 1103. It is connected to the stopper 1104 of the stopper 1103, the stopper 1104 is connected to the diagnostic body 1105, the diagnostic body has a space 1107 and the diagnostic means (including battery) 1106. In this case, when the needle 1101 is inserted into the skin, the substance (blood) in the blood reacts with the rupture means 1102, and thus the blood moves to the space 1107, and the blood is transferred to the diagnostic apparatus 1106. Will be supplied. As mentioned earlier, keeping the space 1107 below atmospheric pressure has the advantage of reducing blood time and shortening the time.

In the embodiment of the diagnostic apparatus, an injection needle is mainly used to extract blood, and one additional injection needle may be used to inject medicine according to a diagnosis result. An embodiment showing this is FIG. 12. The diagnostic prescription unit (including the battery) 1200 has a structure in which the test needle 1202 and the prescription needle 1203 are connected to the body 1201. Blood introduced through the test needle 1202 is examined by a test means (not shown) in the diagnostic prescription unit 1200 so that the medicine can be supplied directly through the needle 1203 if necessary. The two needles may be two needles separately or may have only two holes in the needle of one body. In the above description, it is described that prescription drugs are automatically supplied through the injection needle 1203. However, the test results may be supplied separately by inserting the needle 1203 of the above-mentioned prescription drug into the skin to supply the medicine at the discretion of the examiner.

So far, the configuration and representative embodiments of the present invention have been described. It is within the scope of the present invention to easily modify the described content of the present invention or to carry out in combination. For example, in the present invention, it was described that the battery which is generated by water is placed on the back of the substrate. Arranging the battery on the upper surface of the substrate together with other components such as a diagnostic part so that the upper surface of the substrate has all the components is included in the scope of the present invention since it can be easily carried out by a person who understands the present invention. do. In the embodiments of the present invention of FIGS. 3 and 6, only the biosensor for testing DNA and blood has been described as an example. However, a person who understands the present invention may invent the present invention in any case when the liquid to be tested contains water. Since it can be used as it is, such a case is included in this invention. For example, when other substances are added based on water such as urine and body fluid, water may operate the battery and the sensor to be inspected may be operated by the energy operated by the battery. In addition, what is described by the present invention is that when a liquid based on water is introduced into the system according to the present invention, the battery of the system generates power using water, and the energy generated is described in FIG. Likewise, it includes all systems in which an energy consuming part that consumes energy, such as a controller required to implement the present invention, can be made as part of the system. For example, if the front side of the substrate is made with an energy-consuming battery such as a radio, a television or a cell phone, and a battery operated by water, the energy-consuming unit may come into contact with an aqueous solution containing water. It can be included in the scope of the present invention.

The system according to the present invention having a battery that starts operation by water on a part of the substrate and an energy consuming part that consumes energy on another part of the substrate is operated by any liquid including water, such as DNA, blood, urine, etc. It is easy to create a system such as a disposable diagnostic device (or diagnostic kit) that is convenient for obtaining biometric information. These advantages make it easier for each individual to be examined by current experts and doctors. In this case, you can buy a single-use diagnostic device in a pharmacy, etc., the desired test. Also, if you make a radio, TV, mobile phone, etc. in the energy consuming part, you can make a convenient system to start operation by water.

Claims (41)

A substrate; An energy generating unit located at a portion of the substrate and capable of starting operation by water; Located in a portion of the substrate and consists of an energy consuming portion that consumes energy; When the liquid containing water comes into contact with the energy generating unit, the energy generating unit starts to generate electrical energy, and supplies the electrical energy to the energy consuming unit to consume energy at the energy consuming unit. System characterized in that. The system of claim 1, wherein the energy generating unit and the energy consuming unit have a structure connected by a flow path so that the liquid can easily flow to a desired position. The system of claim 1, wherein said energy dissipation unit analyzes a liquid comprising a substance extracted from a human body. 4. The system of claim 3, wherein said energy consuming portion is a Chip (or Microarray) which analyzes at least one of DNA, RNA or protein. 4. The system of claim 3 wherein said energy dissipation unit is an analytical device for analyzing some or all of the components of blood. 4. The system of claim 3, wherein said energy dissipation unit is an analytical device that analyzes some or all of the components of urine. The method of claim 1, wherein the energy-consuming portion of at least one of blood, saliva, runny nose, urine, vaginal discharge, serving, body fluid, DNA, RNA, protein, tissue and plant sap, DNA, RNA, tissue of the animal System characterized in that for analyzing. The system of claim 1, wherein the energy consumption unit is capable of at least one of transmitting or receiving a signal to and from the outside. The system of claim 8, wherein the energy consumption unit is a communication device that transmits and receives at least one or more of information such as voice information, image information, and data to the outside. 9. The system according to claim 8, wherein said energy dissipation unit is a television capable of showing voice information and image information. The system of claim 8, wherein the energy consumption unit is a radio capable of receiving only voice information. The system according to claim 1, wherein said energy generating unit is a battery which starts to operate with water. 13. The system of claim 12, having a battery comprising a porous material, such as space or paper, such that the aqueous solution comprising water can move well by surface tension. The method of claim 12, wherein the battery uses magnesium chloride (AgCl) or copper chloride (CuCul) as an anode and magnesium as a cathode, and when the battery is in contact with a liquid containing water, The system characterized in that the start to generate electrical energy. The liquid according to claim 1, 2 or 3, wherein the liquid moves to a predetermined position by surface tension when the liquid is in contact with the energy generating portion and the energy dissipating portion. system. 3. A system according to claim 1 and 2, having a liquid inlet connected to said flow path for easy receipt of said liquid. 17. The system of claim 16, wherein said liquid inlet is a hole. 17. The system of claim 16, wherein said liquid inlet portion is a needle. 19. The system of claim 18, wherein said needle has a stopper so that it can poke to a defined depth when pierced into the skin. 20. The device according to claim 18 and 19, further comprising a device for holding the needle in a position facing the needle in order to prevent the needle from sticking to the skin when the needle is inserted into the skin and then removed. System characterized. 21. The system of claim 20, wherein said needle and said device for holding said needle utilize gearing. 21. A system according to claim 18, 19 and 20, wherein said needle destroys the rupture means when the needle is pierced at a desired site. 23. The system of claim 22, wherein the rupture means is a membrane. 21. The method according to claim 18, 19 or 20, characterized in that when the needle is pierced in a desired area, it has a material that reacts with the component of the liquid or dissolves in the liquid component as a rupture means. System. 25. A system according to claim 22 and 24, wherein said relatively low pressure on the side of said system is maintained relative to said rupture means so that said liquid flows well into said system. 19. The system according to claim 3, 7, or 18, wherein the system has a drug holding unit that has the necessary medicines according to the above analysis results. 27. The system of claim 26, wherein the medicine is injected automatically through a needle or manually if necessary. According to claim 1, wherein the energy consumption section is the end of the analysis of the information of the desired living body, the display unit for displaying the result of diagnosis in the diagnosis unit, the input unit for selecting the required diagnosis or input the information, the necessary information It is composed of a combination of a memory unit capable of storing, a transmitter which transmits the processed signal to the outside as needed or can be received externally, and a control unit which can adjust or instruct the movement of each unit as described above to perform a desired diagnosis. System. 29. The system of claim 28, wherein the transmitter transmits and receives a signal by wire using a waveguide such as a conductor or an optical cable. 29. The apparatus of claim 28, wherein the transceiver transmits and receives signals wirelessly by using electromagnetic waves including lasers, visible rays, ultraviolet rays, infrared rays, radio waves of a frequency used for radio or television, and sound waves including ultrasonic waves. System characterized in that. A substrate; At least one electrode positioned on the substrate and capable of applying a voltage; A chamber for receiving an aqueous solution containing a substance charged on the electrode; A permeation layer formed on the electrode to avoid direct electrical contact between the aqueous solution and the electrode; A sensing unit for detecting whether the charged material is attached when the charged material in the aqueous solution is deposited on the transmission layer; When the aqueous solution flows into the space, the electric field is formed around the electrode by applying a voltage to the electrode, so that the charged material in the aqueous solution is formed on the electrode. And attach to the permeable layer to detect with said sensing unit whether said charged substance is in said aqueous solution. 32. The system of claim 31, wherein a corresponding electrode is placed at a predetermined interval while facing the electrode to facilitate the formation of an electric field in the electrode. 32. The method of claim 31, wherein a biological probe such as DNA or RNA is previously placed on the permeable layer formed on the electrode, and when hybridization occurs due to a biological material corresponding to the aqueous solution. And a sensing unit detects the presence or absence of the aforementioned coupling. 34. The battery according to claim 31, 32, 33, wherein the operation is started by using an aqueous solution containing water when electrical energy is required, such as by forming the electric field and detecting by the sensing unit. The system characterized by having a. 32. The method according to claim 31, wherein when the detection unit detects the blood, saliva, runny nose, urine, vaginal discharge, phosphorus, cellular tissues, etc. The system characterized in that using the aqueous solution containing the biological sample. 34. The method according to claim 31, 32, 33, wherein when the charge-bearing material in the aqueous solution is deposited on the transmission layer on the electrode, the capacitance, resistance, inductance ( And a sensor for detecting at least one of the impedance components of the inductance, the sensor including a sensor for detecting attachment of a charged material on the transmission layer using the impedance change. 34. The hole according to claim 31, 32, 33, wherein when the charge-bearing material in the aqueous solution is attached onto the permeable layer on the electrode, the material bears a magnetic field, such as a small magnet. And a sensing unit for sensing a change in the magnetic field, such as a Hall sensor, to detect the attachment of a charged material to the transmission layer. 33. The method according to claim 31 and 32, wherein when a charged material is attached to the above-mentioned transmission layer, electromagnetic waves such as laser, visible light, ultraviolet ray, infrared ray, and radio wave are irradiated to the portion to which the charged material is attached. By using the reflection transmission characteristics of the electromagnetic wave, the system characterized in that it has a sensing unit for detecting whether the above-mentioned charge-bearing material is attached. 33. The method of claim 31 and 32, wherein when a charged material is attached to the transmission layer, a sound wave including ultrasonic waves is irradiated to a portion to which the charged material is attached, thereby transmitting the reflection of the sound wave. And a sensing unit for detecting whether the charged material is attached using the characteristic. 40. The system of claim 38 and 39, wherein the charged material comprises a material that changes reflection transmission properties in order to increase or decrease the reflection transmission properties of electromagnetic waves and ultrasonic waves. . A substrate; An energy generating unit located on a portion of the substrate and capable of starting operation by water in an aqueous solution containing a substance to be detected or inspected; Located in a portion of the substrate and consumes energy, consisting of an energy consumption unit for detecting how much the material to be contained in the aqueous solution contained; When the aqueous solution flows in, energy is generated in the energy generating unit by water in the aqueous solution, and detecting or inspecting a substance contained in the aqueous solution while using the energy in the energy consuming unit. System characterized.

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