KR102703061B1 - Antibacterial and Preservative Compositions - Google Patents
Antibacterial and Preservative Compositions Download PDFInfo
- Publication number
- KR102703061B1 KR102703061B1 KR1020210084968A KR20210084968A KR102703061B1 KR 102703061 B1 KR102703061 B1 KR 102703061B1 KR 1020210084968 A KR1020210084968 A KR 1020210084968A KR 20210084968 A KR20210084968 A KR 20210084968A KR 102703061 B1 KR102703061 B1 KR 102703061B1
- Authority
- KR
- South Korea
- Prior art keywords
- chemical formula
- antibacterial
- composition
- compound represented
- product
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims abstract description 172
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 102
- 239000003755 preservative agent Substances 0.000 title description 6
- 230000002335 preservative effect Effects 0.000 title description 5
- 239000000126 substance Substances 0.000 claims abstract description 70
- 150000001875 compounds Chemical class 0.000 claims abstract description 43
- 239000002537 cosmetic Substances 0.000 claims abstract description 29
- 239000003845 household chemical Substances 0.000 claims abstract description 15
- 239000003205 fragrance Substances 0.000 claims abstract description 10
- 230000000845 anti-microbial effect Effects 0.000 claims description 38
- 241000894006 Bacteria Species 0.000 claims description 31
- 241000228245 Aspergillus niger Species 0.000 claims description 29
- 241000222122 Candida albicans Species 0.000 claims description 29
- 241000588724 Escherichia coli Species 0.000 claims description 28
- 239000003599 detergent Substances 0.000 claims description 28
- 239000004599 antimicrobial Substances 0.000 claims description 14
- 244000005700 microbiome Species 0.000 claims description 13
- XTJKNGLLPGBHHO-HNNXBMFYSA-N (2s)-5-(diaminomethylideneamino)-2-(dodecanoylamino)pentanoic acid Chemical compound CCCCCCCCCCCC(=O)N[C@H](C(O)=O)CCCN=C(N)N XTJKNGLLPGBHHO-HNNXBMFYSA-N 0.000 claims description 12
- 239000004288 Sodium dehydroacetate Substances 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 11
- 229940081510 piroctone olamine Drugs 0.000 claims description 11
- 229940079839 sodium dehydroacetate Drugs 0.000 claims description 11
- 235000019259 sodium dehydroacetate Nutrition 0.000 claims description 11
- 239000006071 cream Substances 0.000 claims description 10
- RGUVUPQQFXCJFC-UHFFFAOYSA-N n-hydroxyoctanamide Chemical compound CCCCCCCC(=O)NO RGUVUPQQFXCJFC-UHFFFAOYSA-N 0.000 claims description 9
- BTSZTGGZJQFALU-UHFFFAOYSA-N piroctone olamine Chemical compound NCCO.CC(C)(C)CC(C)CC1=CC(C)=CC(=O)N1O BTSZTGGZJQFALU-UHFFFAOYSA-N 0.000 claims description 9
- DSOWAKKSGYUMTF-GZOLSCHFSA-M sodium;(1e)-1-(6-methyl-2,4-dioxopyran-3-ylidene)ethanolate Chemical compound [Na+].C\C([O-])=C1/C(=O)OC(C)=CC1=O DSOWAKKSGYUMTF-GZOLSCHFSA-M 0.000 claims description 9
- 241000589517 Pseudomonas aeruginosa Species 0.000 claims description 4
- 241000191967 Staphylococcus aureus Species 0.000 claims description 4
- 229940095731 candida albicans Drugs 0.000 claims description 4
- 239000000839 emulsion Substances 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 4
- 239000000344 soap Substances 0.000 claims description 3
- 239000007921 spray Substances 0.000 claims description 3
- 239000004094 surface-active agent Substances 0.000 claims description 3
- 239000002386 air freshener Substances 0.000 claims description 2
- 239000000645 desinfectant Substances 0.000 claims description 2
- 238000004851 dishwashing Methods 0.000 claims description 2
- 239000000725 suspension Substances 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 13
- 238000004140 cleaning Methods 0.000 abstract description 3
- 206010040880 Skin irritation Diseases 0.000 abstract description 2
- 230000000704 physical effect Effects 0.000 abstract description 2
- 230000036556 skin irritation Effects 0.000 abstract description 2
- 231100000475 skin irritation Toxicity 0.000 abstract description 2
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 239000000047 product Substances 0.000 description 56
- 238000004519 manufacturing process Methods 0.000 description 55
- -1 wet wipes Substances 0.000 description 22
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 20
- 230000000052 comparative effect Effects 0.000 description 15
- 239000012085 test solution Substances 0.000 description 14
- 239000007788 liquid Substances 0.000 description 13
- 239000002453 shampoo Substances 0.000 description 12
- 239000012141 concentrate Substances 0.000 description 11
- 241000233866 Fungi Species 0.000 description 9
- 239000008278 cosmetic cream Substances 0.000 description 9
- 230000012010 growth Effects 0.000 description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 230000000813 microbial effect Effects 0.000 description 5
- 239000008213 purified water Substances 0.000 description 5
- 239000003242 anti bacterial agent Substances 0.000 description 4
- 239000002609 medium Substances 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 230000001747 exhibiting effect Effects 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 231100000481 chemical toxicant Toxicity 0.000 description 2
- 230000006866 deterioration Effects 0.000 description 2
- 239000008121 dextrose Substances 0.000 description 2
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 230000014509 gene expression Effects 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 239000002054 inoculum Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 229940045990 sodium laureth-2 sulfate Drugs 0.000 description 2
- GUQPDKHHVFLXHS-UHFFFAOYSA-M sodium;2-(2-dodecoxyethoxy)ethyl sulfate Chemical compound [Na+].CCCCCCCCCCCCOCCOCCOS([O-])(=O)=O GUQPDKHHVFLXHS-UHFFFAOYSA-M 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 239000011550 stock solution Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 239000000454 talc Substances 0.000 description 2
- 229910052623 talc Inorganic materials 0.000 description 2
- 239000003440 toxic substance Substances 0.000 description 2
- 239000001974 tryptic soy broth Substances 0.000 description 2
- 108010050327 trypticase-soy broth Proteins 0.000 description 2
- GZIFEOYASATJEH-VHFRWLAGSA-N δ-tocopherol Chemical compound OC1=CC(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 GZIFEOYASATJEH-VHFRWLAGSA-N 0.000 description 2
- VAXHWOHZQDBNDT-UHFFFAOYSA-N 1,2-benzothiazole 1-oxide 1,2-benzothiazol-3-one Chemical compound C1=CC=C2C(=O)NSC2=C1.C1=CC=C2S(=O)N=CC2=C1 VAXHWOHZQDBNDT-UHFFFAOYSA-N 0.000 description 1
- VUWCWMOCWKCZTA-UHFFFAOYSA-N 1,2-thiazol-4-one Chemical class O=C1CSN=C1 VUWCWMOCWKCZTA-UHFFFAOYSA-N 0.000 description 1
- 229940058015 1,3-butylene glycol Drugs 0.000 description 1
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 1
- DWHIUNMOTRUVPG-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-(2-dodecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol Chemical compound CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCO DWHIUNMOTRUVPG-UHFFFAOYSA-N 0.000 description 1
- 229940100555 2-methyl-4-isothiazolin-3-one Drugs 0.000 description 1
- VWGWFMQZURGKKK-UHFFFAOYSA-N 3-(dodecylamino)propane-1,2-diol Chemical compound CCCCCCCCCCCCNCC(O)CO VWGWFMQZURGKKK-UHFFFAOYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
- GZIFEOYASATJEH-UHFFFAOYSA-N D-delta tocopherol Natural products OC1=CC(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 GZIFEOYASATJEH-UHFFFAOYSA-N 0.000 description 1
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 description 1
- XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 description 1
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 description 1
- 239000004367 Lipase Substances 0.000 description 1
- 102000004882 Lipase Human genes 0.000 description 1
- 108090001060 Lipase Proteins 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 229920001214 Polysorbate 60 Polymers 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- ULGYAEQHFNJYML-UHFFFAOYSA-N [AlH3].[Ca] Chemical compound [AlH3].[Ca] ULGYAEQHFNJYML-UHFFFAOYSA-N 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 150000004996 alkyl benzenes Chemical class 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 239000003429 antifungal agent Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 229940077388 benzenesulfonate Drugs 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 239000003139 biocide Substances 0.000 description 1
- 238000002815 broth microdilution Methods 0.000 description 1
- 235000019437 butane-1,3-diol Nutrition 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 231100000357 carcinogen Toxicity 0.000 description 1
- 239000003183 carcinogenic agent Substances 0.000 description 1
- 239000003093 cationic surfactant Substances 0.000 description 1
- 229940082500 cetostearyl alcohol Drugs 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- DHNRXBZYEKSXIM-UHFFFAOYSA-N chloromethylisothiazolinone Chemical compound CN1SC(Cl)=CC1=O DHNRXBZYEKSXIM-UHFFFAOYSA-N 0.000 description 1
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 description 1
- 229940073507 cocamidopropyl betaine Drugs 0.000 description 1
- 230000008094 contradictory effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 229940086555 cyclomethicone Drugs 0.000 description 1
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 235000010389 delta-tocopherol Nutrition 0.000 description 1
- 230000002542 deteriorative effect Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 229940008099 dimethicone Drugs 0.000 description 1
- 239000004205 dimethyl polysiloxane Substances 0.000 description 1
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- FOYKKGHVWRFIBD-UHFFFAOYSA-N gamma-tocopherol acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 FOYKKGHVWRFIBD-UHFFFAOYSA-N 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 229940075529 glyceryl stearate Drugs 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- MGIYRDNGCNKGJU-UHFFFAOYSA-N isothiazolinone Chemical compound O=C1C=CSN1 MGIYRDNGCNKGJU-UHFFFAOYSA-N 0.000 description 1
- 229940031674 laureth-7 Drugs 0.000 description 1
- 235000019421 lipase Nutrition 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- BEGLCMHJXHIJLR-UHFFFAOYSA-N methylisothiazolinone Chemical compound CN1SC=CC1=O BEGLCMHJXHIJLR-UHFFFAOYSA-N 0.000 description 1
- 230000007269 microbial metabolism Effects 0.000 description 1
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 1
- 229940101267 panthenol Drugs 0.000 description 1
- 235000020957 pantothenol Nutrition 0.000 description 1
- 239000011619 pantothenol Substances 0.000 description 1
- 230000009340 pathogen transmission Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 description 1
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 description 1
- 229940113124 polysorbate 60 Drugs 0.000 description 1
- 239000001965 potato dextrose agar Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 235000021067 refined food Nutrition 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 229940057950 sodium laureth sulfate Drugs 0.000 description 1
- ZUFONQSOSYEWCN-UHFFFAOYSA-M sodium;2-(methylamino)acetate Chemical compound [Na+].CNCC([O-])=O ZUFONQSOSYEWCN-UHFFFAOYSA-M 0.000 description 1
- SXHLENDCVBIJFO-UHFFFAOYSA-M sodium;2-[2-(2-dodecoxyethoxy)ethoxy]ethyl sulfate Chemical compound [Na+].CCCCCCCCCCCCOCCOCCOCCOS([O-])(=O)=O SXHLENDCVBIJFO-UHFFFAOYSA-M 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- 229950011392 sorbitan stearate Drugs 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
- VLPFTAMPNXLGLX-UHFFFAOYSA-N trioctanoin Chemical compound CCCCCCCC(=O)OCC(OC(=O)CCCCCCC)COC(=O)CCCCCCC VLPFTAMPNXLGLX-UHFFFAOYSA-N 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000004711 α-olefin Substances 0.000 description 1
- 239000002446 δ-tocopherol Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/08—Amines; Quaternary ammonium compounds containing oxygen or sulfur
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/16—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds containing nitrogen-to-oxygen bonds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/14—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
- A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
- A01N47/44—Guanidine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/43—Guanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
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- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
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Abstract
본 발명은 의류나 접시, 주거공간의 세정 또는 발향제품, 물티슈, 화장품 등에 사용되는 물을 함유하는 제품들에 있어 부패를 방지하고, 물성을 보존하는 목적으로 하는 항균용 조성물 및 이를 함유하는 화장품, 위생용품, 생활화학제품과 같은 제품에 관한 것이다. 본 발명의 항균용 조성물에는 화학식 1로 표시되는 화합물과, 화학식 2로 표시되는 화합물을 포함함으로써 인체 유해성, 피부자극 등의 문제를 해소할 수 있으면서 항균력을 증진시킬 수 있다.The present invention relates to an antibacterial composition for preventing decay and preserving the physical properties of products containing water, such as clothing, dishes, cleaning or fragrance products for living spaces, wet tissues, and cosmetics, and to products such as cosmetics, hygiene products, and household chemical products containing the same. The antibacterial composition of the present invention comprises a compound represented by the chemical formula 1 and a compound represented by the chemical formula 2, thereby resolving problems such as human harmfulness and skin irritation, and enhancing antibacterial activity.
Description
본 발명은 의류나 접시, 주거공간의 세정 또는 발향제품, 물티슈, 샴푸, 화장품(크림, 립스틱 등) 등에 사용되는 물을 함유하는 제품, 물을 포함하지 않는 제품(화장품 팩트) 에 있어 부패를 방지하고 물성을 보존하기 위한 항균용 조성물 및 이를 함유하는 제품에 관한 것이다.The present invention relates to an antibacterial composition and a product containing the same for preventing spoilage and preserving physical properties of products containing water, such as clothing, dishes, cleaning or fragrance products for living spaces, wet tissues, shampoos, cosmetics (creams, lipsticks, etc.), and products that do not contain water (cosmetic compacts).
물을 함유하는 모든 제품은 미생물의 번식이 용이하기 때문에 필수적으로 항균제가 사용된다. 항균제란 세균의 성장을 억제하거나 죽이는 약제를 말한다.All products containing water are prone to the growth of microorganisms, so antimicrobial agents are essential. Antimicrobial agents are agents that inhibit the growth of bacteria or kill them.
특히 물이 많이 포함되는 세정제 제품들은 품질을 오랫동안 유지하기 위해서 미생물에 의한 부패를 막아주는 항균제를 필수적으로 포함한다. 이러한 제품들은 유통기간이 매우 길며, 그 사용 과정 및 보관 방법에 있어서 미생물과 접촉할 가능성이 매우 높으며, 각종 탄소원과 질소원이 배합되어 있고 미생물 생장에 필수적인 수분의 함량도 높다는 점에서 항균제 성분이 필수적이다.In particular, detergent products containing a lot of water must contain antimicrobial agents to prevent microbial spoilage in order to maintain quality for a long time. These products have a very long shelf life, and are very likely to come into contact with microorganisms during their use and storage, and contain various carbon and nitrogen sources, and have a high moisture content essential for microbial growth, so antimicrobial agents are essential.
최근 항균제의 인체 유해성이 논란이 되고 있으나 제품에 항균제를 사용하지 않거나 항균력이 약할 경우 제품의 변질과 병원균의 전염 위험이 클 뿐만 아니라, 미생물 대사로 인한 피부 트러블, 질환의 원인이 되어 항균제의 사용은 불가피한 실정이다.Recently, the harmfulness of antimicrobial agents to the human body has been debated, but if antimicrobial agents are not used in a product or the antimicrobial effect is weak, not only is there a high risk of product deterioration and pathogen transmission, but microbial metabolism can also cause skin troubles and diseases, so the use of antimicrobial agents is unavoidable.
의류나 접시, 주거공간의 세정 또는 발향 제품군, 물티슈, 샴푸, 화장품(크림, 립스틱 등) 등에는 아직도 유독 화학물질인 메칠이소치아졸리논 (Methylisothiazolinone), 클로로메칠이소치아졸리논(Chloromethylisothiazolinone), 벤즈이소치아졸리논(1,2-benzisothiazol-3(2H)-one) 등 이소치아졸리논계 성분들이 보존의 목적으로 사용되고 있다.Isothiazolinone-based ingredients such as methylisothiazolinone, chloromethylisothiazolinone, and benzisothiazolinone (1,2-benzisothiazol-3(2H)-one), which are toxic chemicals, are still used for preservation purposes in products such as clothing, dishes, and household cleaning or fragrance products, wet wipes, shampoos, and cosmetics (creams, lipsticks, etc.).
유독 화학물질인 이소치아졸리논계 성분들은 경제적이고 효과가 강력하다는 이유로 가장 널리 응용되고 있지만 발암물질로 작용할 수 있어 규제가 확대되고 있다.Isothiazolinones, which are toxic chemicals, are the most widely used because they are economical and effective, but regulations are expanding because they can act as carcinogens.
최근에는 항균제가 국민 보건에 영향을 줄 수 있어 국내에서는 제품군 별로 규제 법규가 강화되고 있다. 물티슈를 위생용품 관리법 상 기타 위생용품으로 포함하도록 하였고, 주방용 세제는 식품의약품안전처 고시로 사용 가능한 원료가 지정되어 있는 등 관련 법규들이 강화되는 등 항균제 규제 강화의 움직임이 가속되고 있지만 항균제의 부적절한 사용으로 안전성이 높고 우수한 항균제의 용도를 좁히고 있는 실정이다.Recently, antimicrobial agents have been strengthened in Korea by product group because they can affect public health. Wet tissues have been included as other sanitary products under the Sanitary Products Management Act, and kitchen detergents have been designated as usable raw materials by the Ministry of Food and Drug Safety, etc., and related laws and regulations are being strengthened. The movement to strengthen antimicrobial agent regulations is accelerating. However, the inappropriate use of antimicrobial agents is narrowing the scope of use of antimicrobial agents with high safety and superiority.
따라서, 화장품, 위생용품 및 생활화학제품을 포함한 제품에서 안전하게 사용할 수 있으면서도 우수한 항균력을 나타내는 항균제가 요구되는 상황이다.Therefore, there is a need for an antibacterial agent that can be safely used in products including cosmetics, hygiene products, and household chemical products while also exhibiting excellent antibacterial properties.
이에, 본 발명의 본 발명자들은 인체에 다양한 경로로 해를 끼치는 종래의 항균제를 사용하지 않고 다른 방식으로 미생물을 제어할 수 있는 방법에 대해 연구 개발 하던 중, 화학식 1로 표시되는 3-라우릴아미노-1,2-프로판디올 화합물에 화학식 2로 표시되는 보존제 화합물을 혼합할 경우 이온성에 제한을 받거나 액체 및 고체 제형에서 장기 보관시 쉽게 가수분해되는 문제점을 극복하여 안전하게 미생물을 제어할 수 있을 것으로 판단하여 본 발명을 완성하였다.Accordingly, the inventors of the present invention, while researching and developing a method for controlling microorganisms in a different way without using conventional antibacterial agents that cause harm to the human body in various ways, judged that mixing a preservative compound represented by chemical formula 2 with a 3-laurylamino-1,2-propanediol compound represented by chemical formula 1 would overcome the problems of being limited in ionicity or easily hydrolyzed during long-term storage in liquid and solid formulations, thereby safely controlling microorganisms, and completed the present invention.
따라서, 본 발명은 구체적으로 하기 화학식 1로 표시되는 화합물과 하기 화학식 2로 표시되는 화합물을 포함하는 항균용 조성물을 제공하는 것을 구체적인 해결과제로 한다.Therefore, the present invention specifically aims to provide an antibacterial composition comprising a compound represented by the following chemical formula 1 and a compound represented by the following chemical formula 2.
나아가, 본 발명은 상기 항균용 조성물을 포함하는 다양한 형태의 제품을 제공하는 것을 특별한 해결과제로 한다.Furthermore, the present invention has as a special problem the provision of various types of products containing the antibacterial composition.
더 나아가, 본 발명은 상기 항균용 조성물을 균에 처리하는 항균 방법을 제공하는 것을 특별한 해결과제로 한다.Furthermore, the present invention has as a special problem a problem of providing an antibacterial method for treating bacteria with the antibacterial composition.
상기 과제를 해결하기 위하여, 본 발명에서는 하기와 같은 수단을 개시한다.In order to solve the above problem, the present invention discloses the following means.
구체적으로, 본 발명은 항균용 조성물로서, (a) 화학식 1로 표시되는 화합물, 및 (b) 화학식 2로 표시되는 화합물을 포함하는 항균용 조성물을 개시한다.Specifically, the present invention discloses an antibacterial composition comprising (a) a compound represented by chemical formula 1, and (b) a compound represented by chemical formula 2.
본 발명의 항균용 조성물은 광범위한 미생물 제어 능력을 나타내며, 방부제에 의한 인체 유해성, 피부자극 등의 문제를 해소할 수 있는 장점이 있다.The antimicrobial composition of the present invention exhibits a wide range of microbial control capabilities and has the advantage of being able to resolve problems such as human harmfulness and skin irritation caused by preservatives.
본 발명은 상기 항균용 조성물을 포함하는 제품을 개시한다.The present invention discloses a product comprising the above antibacterial composition.
본 발명은 상기 항균용 조성물을 균에 처리하는 단계를 포함하는 항균 방법을 개시한다.The present invention discloses an antibacterial method comprising a step of treating bacteria with the antibacterial composition.
본 발명자들이 발명한 성분들을 조합함으로써 항균 활성에 있어서 상승효과(Synergy effect)를 나타낼 수 있다.By combining the components invented by the present inventors, a synergistic effect in antibacterial activity can be exhibited.
또한, 본 발명자들이 발명한 항균용 조성물을 화장품, 위생용품, 생활화학제품과 같은 다양한 제품들에 포함할 경우 계면활성제 특성에 맞게 유화, 가용화를 지원하면서도 항균 활성이 우수하고, 폭넓은 항균 스펙트럼을 나타낼 수 있다.In addition, when the antibacterial composition invented by the present inventors is included in various products such as cosmetics, hygiene products, and household chemical products, it can exhibit excellent antibacterial activity and a wide antibacterial spectrum while supporting emulsification and solubilization according to the characteristics of the surfactant.
또한, 본 발명의 항균용 조성물은 음이온과 비이온 계면활성제 베이스의 조성물, 양이온 계면활성제 베이스의 조성물에서 광범위하게 효능을 구현할 수 있으므로 폭넓은 응용범위를 나타낼 수 있다.In addition, the antibacterial composition of the present invention can exhibit a wide range of effects in a composition based on anionic and nonionic surfactants and a composition based on cationic surfactants, and thus can exhibit a wide range of applications.
본 발명의 효과는 이상에서 언급한 효과들로 제한되지 않으며, 이하에서 설명할 내용으로부터 통상의 기술자에게 자명한 범위 내에서 다양한 효과들이 포함될 수 있다.The effects of the present invention are not limited to the effects mentioned above, and various effects may be included within a range obvious to those skilled in the art from the contents described below.
이하 본 명세서에 대하여 더욱 상세히 설명한다.The following describes this specification in more detail.
이를 구체적으로 설명하면 다음과 같다. 한편, 본 발명에서 개시된 각각의 설명 및 실시형태는 각각에 대한 다른 설명 및 실시형태에도 적용될 수 있다. 즉, 본 발명에 개시된 다양한 요소들의 모든 조합이 본 발명의 범주에 속한다. 또한, 하기에 기술된 구체적인 서술에 의하여 본 발명의 범주가 제한된다고 볼 수 없다.This is explained specifically as follows. Meanwhile, each description and embodiment disclosed in the present invention can also be applied to other descriptions and embodiments for each. That is, all combinations of various elements disclosed in the present invention fall within the scope of the present invention. In addition, the scope of the present invention cannot be considered to be limited by the specific description described below.
본 명세서에서 사용되는 「포함하는」과 같은 표현은, 해당 표현이 포함되는 문구 또는 문장에서 특별히 다르게 언급되지 않는 한, 다른 실시예를 포함할 가능성을 내포하는 개방형 용어(open-ended terms)로 이해되어야 한다.Expressions such as “including” as used herein should be understood as open-ended terms implying the possibility of including other embodiments, unless specifically stated otherwise in the phrase or sentence in which the expression is included.
본 발명의 설명 및 청구범위에서 사용된 용어나 단어는, 통상적이거나 사전적인 의미로 한정해서 해석되어서는 아니되며, 발명자는 그 자신의 발명을 가장 최선을 방법으로 설명하기 위해 용어의 개념을 적절하게 정의할 수 있다는 원칙에 입각하여, 본 발명의 기술적 사상에 부합하는 의미와 개념으로 해석되어야만 한다.The terms or words used in the description and claims of the present invention should not be interpreted as limited to their usual or dictionary meanings, but should be interpreted as meanings and concepts that conform to the technical idea of the present invention, based on the principle that the inventor can appropriately define the concept of the term in order to explain his or her own invention in the best possible manner.
항균용 조성물Antibacterial composition
본 발명은 항균용 조성물로서, (a) 화학식 1로 표시되는 화합물, 및 (b) 화학식 2로 표시되는 화합물을 포함하는 것인 항균용 조성물을 제공한다.The present invention provides an antibacterial composition comprising (a) a compound represented by chemical formula 1, and (b) a compound represented by chemical formula 2.
[화학식 1][Chemical Formula 1]
[화학식 2][Chemical formula 2]
상기 화학식 2로 표시되는 화합물에서,In the compound represented by the above chemical formula 2,
L3 는 -C(=O)-, -(CH=CH)-(CH2)o- -C(CH3)2-CH2-CH(CH3)-CH2- 또는 -(CH2)p- 이고,L 3 is -C(=O)-, -(CH=CH)-(CH 2 ) o - -C(CH 3 ) 2 -CH 2 -CH(CH 3 )-CH 2 - or -(CH 2 ) p - and,
o 및 p는 각각 독립적으로 1 내지 15의 정수이며,o and p are each independently an integer from 1 to 15,
-(CH2)p- 에는 C1 내지 C15 알킬기가 치환될 수 있고,-(CH 2 ) p - may be substituted with a C 1 to C 15 alkyl group,
R4 는 , -C(=O)-NH-OH, 또는 이며,R 4 is , -C(=O)-NH-OH, or And,
X는 NH2-CH2-CH2-OH 또는 아무것도 아님(Null).X is NH 2 -CH 2 -CH 2 -OH or nothing (Null).
본 발명에 있어서, 용어 『항균용 조성물』이란, 방부 조성물을 의미할 수 있으며, 이들이 첨가되는 조성물의 변질, 부패, 변색 및 화학변화를 방지하기 위해 사용될 수 있는 모든 첨가물을 포함할 수 있으며, 세균, 곰팡이, 효모 등의 미생물의 증식을 억제하여 부패 미생물의 발육저지 또는 살균 작용을 하는 등의 기능성 항생제도 포함할 수 있다.In the present invention, the term “antibacterial composition” may mean a preservative composition, and may include all additives that can be used to prevent deterioration, decay, discoloration, and chemical changes of the composition to which they are added, and may also include functional antibiotics that inhibit the growth of microorganisms such as bacteria, mold, and yeast, thereby inhibiting the growth of putrefactive microorganisms or having a sterilizing effect.
본 발명에 있어서, 상기 항균용 조성물은 대장균(Escherichia Coli), 황색포도상구균(Staphylococcus Aureus), 녹농균(Pseudomonas Aeruginosa), 아스퍼질러스 니제르(Aspergillus niger) 및 칸디다 알비칸스(Candida albicans)로 이루어진 군으로부터 선택된 하나 이상의 미생물에 항균 활성을 나타낼 수 있다. In the present invention, the antibacterial composition can exhibit antibacterial activity against one or more microorganisms selected from the group consisting of Escherichia Coli , Staphylococcus Aureus , Pseudomonas Aeruginosa , Aspergillus niger , and Candida albicans.
본 발명에 있어서, 화학식 1 및 화학식 2로 표시되는 화합물은 보존제 화합물이다. 용어 『보존제』란, 산업적으로 생산하여 유통되는 가공식품, 음료, 화장품, 의약품, 위생용품, 생활화학제품 등의 품질을 관리하기 위해 첨가하는 화학물질로, 제품에 있어 미생물에 의한 부패 또는 화학성분의 분해에 의해 품질이 떨어지거나 변질되는 것을 예방하기 위해 사용된다. 즉, 세균, 곰팡이 및 효모 중 적어도 하나이상의 미생물에 대한 항균력을 나타낼 수 있어, 항미생물 및/또는 항박테리아 및/또는 항진균제로서 사용되는 것을 의미한다.In the present invention, the compounds represented by Chemical Formula 1 and Chemical Formula 2 are preservative compounds. The term "preservative" refers to a chemical substance added to manage the quality of processed foods, beverages, cosmetics, pharmaceuticals, sanitary products, household chemical products, etc. that are industrially produced and distributed, and is used to prevent the quality of the products from deteriorating or becoming spoiled due to microbial spoilage or decomposition of chemical components. In other words, it means that it can exhibit antibacterial activity against at least one or more microorganisms among bacteria, molds, and yeasts, and is used as an antimicrobial and/or antibacterial and/or antifungal agent.
본 발명에 있어서, 항균용 조성물은, 대장균(Escherichia Coli), 황색포도상구균(Staphylococcus Aureus), 녹농균(Pseudomonas Aeruginosa), 아스퍼질러스 니제르(Aspergillus niger) 및 칸디다 알비칸스(Candida albicans)로 이루어진 군에서 선택된 적어도 하나 이상의 미생물을 제어하기 위한 것일 수 있으며, 이에 한정되는 것은 아니다.In the present invention, the antibacterial composition may be for controlling at least one microorganism selected from the group consisting of Escherichia Coli , Staphylococcus Aureus , Pseudomonas Aeruginosa , Aspergillus niger , and Candida albicans, but is not limited thereto.
본 발명에 있어서, 상기 화학식 1로 표시되는 화합물과 화학식 2로 표시되는 화합물은 0.01:9.99 내지 9.99:0.01의 중량비로 포함될 수 있으며, 구체적으로 화학식 1로 표시되는 화합물과 화학식 2로 표시되는 화합물은 6 : 4, 7 : 3 및/또는 8 : 2의 중량비로 포함될 수 있고, 이에 한정되는 것은 아니다.In the present invention, the compound represented by the chemical formula 1 and the compound represented by the chemical formula 2 may be included in a weight ratio of 0.01:9.99 to 9.99:0.01, and specifically, the compound represented by the chemical formula 1 and the compound represented by the chemical formula 2 may be included in a weight ratio of 6:4, 7:3, and/or 8:2, but is not limited thereto.
구체적으로, 상기 화학식 1로 표시되는 화합물과 화학식 2로 표시되는 화합물이 상기 범위 내의 함량으로 포함됨으로써 미생물 제어 효과가 상승하는 이점이 있다.Specifically, there is an advantage in that the microbial control effect is increased by including the compound represented by the chemical formula 1 and the compound represented by the chemical formula 2 in an amount within the above range.
본 발명에 있어서, 화학식 1로 표시되는 화합물인 3-라우릴아미노-1,2-프로판디올 화합물은 하기와 같은 화학식을 가지고 있다.In the present invention, the 3-laurylamino-1,2-propanediol compound represented by chemical formula 1 has the following chemical formula.
[화학식 1] [Chemical Formula 1]
구체적으로, 상기 화학식 1로 표시되는 화합물은 유화, 가용화 효능이 우수한 화합물로서, 화학식 2로 표시되는 화합물과 혼합하여 항균제 조성물을 이룸으로써 대장균(Escherichia Coli), 황색포도상구균(Staphylococcus Aureus), 녹농균(Pseudomonas Aeruginosa), 아스퍼질러스 니제르(Aspergillus niger) 및 칸디다 알비칸스(Candida albicans)와 같은 미생물을 억제할 수 있어, 항균 성질을 나타낼 수 있고, 액상과 고상 형태의 화장품, 위생용품, 생활화학제품과 같은 다양한 제품들로 적용할 수 있는 이점이 있다.Specifically, the compound represented by the chemical formula 1 is a compound having excellent emulsifying and solubilizing effects, and when mixed with the compound represented by the chemical formula 2 to form an antibacterial composition, it can inhibit microorganisms such as Escherichia Coli , Staphylococcus Aureus , Pseudomonas Aeruginosa , Aspergillus niger , and Candida albicans , thereby exhibiting antibacterial properties and having the advantage of being applicable to various products such as cosmetics, sanitary products, and household chemical products in liquid and solid forms.
본 발명에 있어서, 상기 화학식 2로 표시되는 화합물에서, L3 는 -C(=O)-, -C(CH3)2-CH2-CH(CH3)-CH2- 또는 -(CH2)p- 이고, p는 5 내지 12의 정수이며, R4 는 , -C(=O)-NH-OH, 또는 이며, X는 NH2-CH2-CH2-OH 또는 아무것도 아닌 (Null) 것일 수 있으며, 이에 한정되는 것은 아니다.In the present invention, in the compound represented by the chemical formula 2, L 3 is -C(=O)-, -C(CH 3 ) 2 -CH 2 -CH(CH 3 )-CH 2 - or -(CH 2 ) p -, p is an integer from 5 to 12, and R 4 is , -C(=O)-NH-OH, or , and X can be, but is not limited to, NH 2 -CH 2 -CH 2 -OH or nothing (Null).
구체적으로, 상기 화학식 2로 표시되는 화합물에서, L3 는 -C(=O)- 이고, R4 는 이고, X는 아무것도 아닌(Null) 것일 수 있으며, 이에 한정되는 것은 아니다.Specifically, in the compound represented by the chemical formula 2, L 3 is -C(=O)- and R 4 is , and X can be, but is not limited to, Null.
또한, 상기 화학식 2로 표시되는 화합물에서, L3 는 -(CH2)p- 이고, -(CH2)p- 에는 C1 내지 C3 알킬기가 치환될 수 있으며, p 는 3 내지 11의 정수이고, R4 는 -C(=O)-NH-OH 또는 이고, X는 아무것도 아닌(Null) 것일 수 있으며, 이에 한정되는 것은 아니다.In addition, in the compound represented by the above chemical formula 2, L 3 is -(CH 2 ) p -, -(CH 2 ) p - may be substituted with a C 1 to C 3 alkyl group, p is an integer of 3 to 11, and R 4 is -C(=O)-NH-OH or , and X can be, but is not limited to, Null.
또한, 상기 화학식 2로 표시되는 화합물에서, L3 는 -C(CH3)2-CH2-CH(CH3)-CH2- 이고, R4 는 이며, X는 NH2-CH2-CH2-OH 일 수 있으며, 이에 한정되는 것은 아니다.In addition, in the compound represented by the chemical formula 2, L 3 is -C(CH 3 ) 2 -CH 2 -CH(CH 3 )-CH 2 -, and R 4 is , and X can be, but is not limited to, NH 2 -CH 2 -CH 2 -OH.
본 발명에 있어서, 상기 화학식 2로 표시되는 화합물은, 소듐 디히드로아세테이트(Sodium dehydroacetate); 카프릴히드록사믹산(caprylhydroxamic acid); 피록톤올아민(Piroctone olamine); 및 라우로일 아르기닌 에틸에스터(Lauroyl arginine ethyl ester)로 이루어진 군에서 선택된 하나 이상일 수 있으며, 이에 한정되는 것은 아니다.In the present invention, the compound represented by the chemical formula 2 may be at least one selected from the group consisting of sodium dehydroacetate; caprylhydroxamic acid; piroctone olamine; and lauroyl arginine ethyl ester, but is not limited thereto.
구체적으로, 소듐 디히드로아세테이트(Sodium dehydroacetate)는 , 카프릴히드록사믹산(caprylhydroxamic acid)은 , 피록톤올아민(Piroctone olamine)은 , 라우로일 아르기닌 에틸에스터(Lauroyl arginine ethyl ester)는 의 구조를 갖는다.Specifically, sodium dehydroacetate , caprylhydroxamic acid , Piroctone olamine is , Lauroyl arginine ethyl ester It has the structure of .
상기 화학식 2로 표시되는 구체 화합물이 화학식 1로 표시되는 3-라우릴아미노-1,2-프로판디올 화합물과 함께 항균용 조성물의 조성으로 사용됨으로써 각각 단독으로 사용한 경우에 비해 세균, 곰팡이, 효모 등의 미생물의 증식을 억제하여 부패 미생물의 발육을 저지할 수 있으며, 또한 살균력이 증가하여 시너지 효과를 나타낼 수 있다.When the specific compound represented by the above chemical formula 2 is used as a composition of an antibacterial composition together with the 3-laurylamino-1,2-propanediol compound represented by the chemical formula 1, the growth of microorganisms such as bacteria, mold, and yeast can be inhibited, thereby preventing the growth of putrefactive microorganisms, compared to when each is used alone, and the sterilizing power can be increased, thereby exhibiting a synergistic effect.
항균용 조성물을 포함하는 제품Products containing antimicrobial compositions
본 발명은 상기 항균용 조성물을 포함하는 제품을 제공한다.The present invention provides a product comprising the above antibacterial composition.
본 발명에 있어서, 상기 제품은 화장품, 위생용품 또는 생활화학제품일 수 있으며, 이에 제한되는 것은 아니다.In the present invention, the product may be a cosmetic, a hygiene product, or a household chemical product, but is not limited thereto.
본 발명에 있어서, 용어 『화장품』이란, 인체를 청결ㆍ미화하여 매력을 더하고 용모를 밝게 변화시키거나 피부ㆍ모발의 건강을 유지 또는 증진하기 위하여 인체에 바르고 문지르거나 뿌리는 등 이와 유사한 방법으로 사용되는 물품으로서 인체에 대한 작용이 경미한 것을 말한다.In the present invention, the term "cosmetics" refers to products that are applied to the human body, rubbed in, sprayed on, or used in a similar manner to cleanse and beautify the human body, add attractiveness, brighten the appearance, or maintain or improve the health of the skin and hair, and that have a mild effect on the human body.
본 발명에 있어서, 용어 『위생용품』이란, 보건위생을 확보하기 위하여 특별한 위생관리가 필요한 용품을 의미한다.In the present invention, the term “sanitary products” means products that require special sanitary management to ensure health and hygiene.
본 발명에 있어서, 용어 『생활화학제품』이란, 가정, 사무실, 다중이용시설 등 일상적인 생활공간에서 사용되는 화학제품으로서 사람이나 환경에 화학물질의 노출을 유발할 가능성이 있는 것을 말한다.In the present invention, the term “household chemical product” refers to a chemical product used in everyday living spaces such as homes, offices, and multi-use facilities, which has the potential to cause exposure of people or the environment to chemical substances.
본 발명에 있어서, 상기 화장품은 화장품법에 따르면 당업계에서 통상적으로 제조되는 어떠한 제형으로 제조될 수 있으며, 용액, 현탁액, 유탁액, 페이스트, 겔, 크림, 팩트, 파우더, 비누, 계면활성제-함유 클린싱, 오일, 유탁액 파운데이션, 왁스 파운데이션 및 스프레이로 이루어진 군에서 선택된 어느 하나로 제형화된 것일 수 있고, 이에 제한되는 것은 아니다. 보다 상세하게는, 유연 화장수, 영양 화장수, 크림, 영양 크림, 마사지 크림, 립스틱, 팩트, 에센스, 아이 크림, 클렌징 크림, 클렌징 폼, 클렌징 워터, 팩, 또는 스프레이의 제형으로 제조될 수 있다.In the present invention, the cosmetic can be manufactured in any formulation commonly manufactured in the art according to the Cosmetics Act, and can be formulated as any one selected from the group consisting of a solution, a suspension, an emulsion, a paste, a gel, a cream, a pact, a powder, a soap, a surfactant-containing cleansing, an oil, an emulsion foundation, a wax foundation, and a spray, but is not limited thereto. More specifically, the cosmetic can be manufactured in the form of a flexible toner, a nourishing toner, a cream, a nourishing cream, a massage cream, a lipstick, a pact, an essence, an eye cream, a cleansing cream, a cleansing foam, a cleansing water, a pack, or a spray.
본 발명에 있어서, 상기 위생용품은 위생용품 관리법에 따르면 식기세정제, 식기세척기용 세정제 및 물티슈로 이루어진 군에서 선택된 것일 수 있고, 이에 제한되는 것은 아니다.In the present invention, the sanitary product may be selected from the group consisting of dishwashing detergent, dishwasher detergent, and wet tissue according to the Sanitary Product Management Act, but is not limited thereto.
본 발명에 있어서, 상기 생활화학제품은 생활화학제품 및 살생물제의 안전관리에 관한 법률에 따르면, 의류세탁세제, 주거공간세정제, 탈취제, 공기세정제, 실내방향제, 발향제, 다목적 세정제, 소독제, 및 제균제로 이루어진 군에서 선택되는 것일 수 있고, 이에 제한되는 것은 아니다.In the present invention, according to the Act on Safety Management of Household Chemical Products and Biocides, the household chemical product may be selected from the group consisting of clothing detergents, residential space cleaners, deodorizers, air cleaners, indoor air fresheners, fragrances, multipurpose cleaners, disinfectants, and sterilizers, but is not limited thereto.
본 발명에 있어서, 상기 항균용 조성물은 상기 화장품, 위생용품 또는 생활화학제품에 대해 0.01 내지 10 중량%로 포함하는 것일 수 있으며, 이에 한정되는 것은 아니다.In the present invention, the antibacterial composition may be included in an amount of 0.01 to 10 wt% with respect to the cosmetic, hygiene product, or household chemical product, but is not limited thereto.
구체적으로, 상기 제품은 의류용 액체세제 조성물, 주방용 세제 조성물, 물티슈 원액 조성물, 삼푸 원액 조성물, 화장품 크림 원액 조성물 및 화장품 팩트 조성물로 이루어진 군에서 선택된 것일 수 있고, 이에 한정되는 것은 아니다.Specifically, the product may be selected from the group consisting of, but is not limited to, a liquid detergent composition for clothing, a kitchen detergent composition, a wet tissue concentrate composition, a shampoo concentrate composition, a cosmetic cream concentrate composition, and a cosmetic pack composition.
의류용 액체세제 조성물Liquid detergent composition for clothing
구체적으로, 항균용 조성물이 포함된 제품이 의류용 액체세제 조성물의 경우, 화학식 1로 표시되는 3-라우릴아미노-1,2-프로판디올 화합물과 화학식 2로 표시되는 소듐 디히드로아세테이트(Sodium dehydroacetate); 카프릴히드록사믹산(caprylhydroxamic acid); 피록톤올아민(Piroctone olamine); 및 라우로일 아르기닌 에틸에스터(Lauroyl arginine ethyl ester) 중 어느 하나의 화합물을 조합한 항균용 조성물을 포함함으로써 E.coli, S.Aureus, P.Aeruginosa, A.niger 및 C.albicans 를 효과적으로 제어할 수 있다.Specifically, in the case of a liquid detergent composition for clothing, the product including the antimicrobial composition comprises an antimicrobial composition combining a 3-laurylamino-1,2-propanediol compound represented by the chemical formula 1 and any one compound among sodium dehydroacetate; caprylhydroxamic acid; piroctone olamine; and lauroyl arginine ethyl ester represented by the chemical formula 2, thereby effectively controlling E. coli, S. Aureus, P. Aeruginosa, A. niger , and C. albicans .
주방용 세제 조성물Kitchen detergent composition
구체적으로, 항균용 조성물이 포함된 제품이 주방용 세제 조성물의 경우, 화학식 1로 표시되는 3-라우릴아미노-1,2-프로판디올 화합물과 화학식 2로 표시되는 소듐 디히드로아세테이트(Sodium dehydroacetate); 카프릴히드록사믹산(caprylhydroxamic acid); 피록톤올아민(Piroctone olamine); 및 라우로일 아르기닌 에틸에스터(Lauroyl arginine ethyl ester) 중 어느 하나의 화합물을 조합한 항균용 조성물을 포함함으로써 E.coli, S.Aureus, P.Aeruginosa, A.niger 및 C.albicans 를 효과적으로 제어할 수 있다.Specifically, in the case of a kitchen detergent composition, the product including the antibacterial composition comprises an antibacterial composition combining a 3-laurylamino-1,2-propanediol compound represented by the chemical formula 1 and any one compound among sodium dehydroacetate; caprylhydroxamic acid; piroctone olamine; and lauroyl arginine ethyl ester represented by the chemical formula 2, thereby effectively controlling E. coli, S. Aureus, P. Aeruginosa, A. niger , and C. albicans .
물티슈 원액 조성물Water tissue original composition
구체적으로, 항균용 조성물이 포함된 제품이 물티슈 원액 조성물의 경우, 3-라우릴아미노-1,2-프로판디올 화합물과 화학식 2로 표시되는 소듐 디히드로아세테이트(Sodium dehydroacetate); 카프릴히드록사믹산(caprylhydroxamic acid); 피록톤올아민(Piroctone olamine); 및 라우로일 아르기닌 에틸에스터(Lauroyl arginine ethyl ester) 중 어느 하나의 화합물을 조합한 항균용 조성물을 포함 함으로써 E.coli, S.Aureus, P.Aeruginosa, A.niger 및 C.albicans 를 효과적으로 제어할 수 있다.Specifically, in the case of a wet tissue stock composition, the product including an antibacterial composition comprises an antibacterial composition combining a 3-laurylamino-1,2-propanediol compound and any one compound of sodium dehydroacetate; caprylhydroxamic acid; piroctone olamine; and lauroyl arginine ethyl ester represented by the chemical formula 2, thereby effectively controlling E. coli, S. Aureus, P. Aeruginosa, A. niger , and C. albicans .
샴푸 원액 조성물Shampoo concentrate composition
구체적으로, 항균용 조성물이 포함된 제품이 샴푸 원액 조성물의 경우, 화학식 1로 표시되는 3-라우릴아미노-1,2-프로판디올 화합물과 화학식 2로 표시되는 소듐 디히드로아세테이트(Sodium dehydroacetate); 카프릴히드록사믹산(caprylhydroxamic acid); 피록톤올아민(Piroctone olamine); 및 라우로일 아르기닌 에틸에스터(Lauroyl arginine ethyl ester) 중 어느 하나의 화합물을 조합한 항균용 조성물을 포함함으로써 E.coli, S.Aureus, P.Aeruginosa, A.niger 및 C.albicans 를 효과적으로 제어할 수 있다.Specifically, in the case of a shampoo stock composition, the product including the antibacterial composition comprises an antibacterial composition combining a 3-laurylamino-1,2-propanediol compound represented by the chemical formula 1 and any one compound among sodium dehydroacetate; caprylhydroxamic acid; piroctone olamine; and lauroyl arginine ethyl ester represented by the chemical formula 2, thereby effectively controlling E. coli, S. Aureus, P. Aeruginosa, A. niger , and C. albicans .
화장품 크림 원액 조성물Cosmetic cream concentrate composition
구체적으로, 항균용 조성물이 포함된 제품이 화장품 크림 원액 조성물의 경우, 화학식 1로 표시되는 3-라우릴아미노-1,2-프로판디올 화합물과 화학식 2로 표시되는 소듐 디히드로아세테이트(Sodium dehydroacetate); 카프릴히드록사믹산(caprylhydroxamic acid); 피록톤올아민(Piroctone olamine); 및 라우로일 아르기닌 에틸에스터(Lauroyl arginine ethyl ester) 중 어느 하나의 화합물을 조합한 항균용 조성물을 포함함으로써 E.coli, S.Aureus, P.Aeruginosa, A.niger 및 C.albicans 를 효과적으로 제어할 수 있다.Specifically, in the case of a cosmetic cream concentrate composition containing an antibacterial composition, the product can effectively control E. coli, S. Aureus, P. Aeruginosa, A. niger and C. albicans by including an antibacterial composition combining a 3-laurylamino-1,2-propanediol compound represented by Chemical Formula 1 and any one compound among sodium dehydroacetate; caprylhydroxamic acid ; piroctone olamine; and lauroyl arginine ethyl ester represented by Chemical Formula 2.
화장품 팩트 조성물Cosmetic Pact Composition
구체적으로, 항균용 조성물이 포함된 제품이 화장품 팩트 조성물의 경우, 화학식 1로 표시되는 3-라우릴아미노-1,2-프로판디올 화합물과 화학식 2로 표시되는 소듐 디히드로아세테이트(Sodium dehydroacetate); 카프릴히드록사믹산(caprylhydroxamic acid); 피록톤올아민(Piroctone olamine); 및 라우로일 아르기닌 에틸에스터(Lauroyl arginine ethyl ester) 중 어느 하나의 화합물을 조합한 항균용 조성물을 포함함으로써 E.coli, S.Aureus, P.Aeruginosa, A.niger 및 C.albicans 를 효과적으로 제어할 수 있다.Specifically, in the case of a cosmetic pack composition, the product including the antibacterial composition comprises an antibacterial composition combining a 3-laurylamino-1,2-propanediol compound represented by Chemical Formula 1 and any one compound among sodium dehydroacetate; caprylhydroxamic acid; piroctone olamine; and lauroyl arginine ethyl ester represented by Chemical Formula 2, thereby effectively controlling E. coli, S. Aureus, P. Aeruginosa, A. niger , and C. albicans .
항균 방법Antibacterial method
본 발명은 상기 항균용 조성물을 균에 처리하는 단계를 포함하는 항균 방법을 제공한다.The present invention provides an antibacterial method comprising a step of treating bacteria with the antibacterial composition.
상기 항균용 조성물을 균에 처리하는 방법은 항균이 필요한 다양한 분야에서 당업자에게 잘 알려진 통상적인 방법에 따라 적절하게 사용될 수 있다. 항균용 조성물의 처리량은 사용목적에 따라 적합하게 결정될 수 있다.The method of treating the above antibacterial composition with bacteria can be appropriately used according to a conventional method well known to those skilled in the art in various fields requiring antibacterial action. The amount of the antibacterial composition to be treated can be appropriately determined depending on the intended use.
본 발명의 항균용 조성물, 항균용 조성물을 포함하는 제품, 항균 방법에서 언급된 사항은 서로 모순되지 않는 한 동일하게 적용된다.The matters mentioned in the antibacterial composition, product containing the antibacterial composition, and antibacterial method of the present invention are equally applicable unless they are contradictory to each other.
이하 본 발명을 바람직한 실시예를 참고로 하여 본 발명이 속하는 기술분야에서 통상의 지식을 가진 자가 용이하게 실시할 수 있도록 다양한 제품에 적용하여 평가하였다. 그러나 본 발명은 여러 가지 상이한 형태로 구현될 수 있으며 아래 기재된 실시예에 한정되는 것은 아니다.Hereinafter, the present invention has been evaluated by applying it to various products with reference to preferred embodiments so that a person having ordinary skill in the art to which the present invention pertains can easily implement it. However, the present invention can be implemented in various different forms and is not limited to the embodiments described below.
제조예 : 항균용 조성물의 제조Manufacturing Example: Manufacturing of an Antibacterial Composition
제조예 1.Manufacturing example 1.
화학식 1로 표시되는 3-라우릴아미노 1,2-프로판디올 화합물과, 화학식 2로 표시되는 소듐 디히드로아세테이트 화합물을 7:3의 중량비로 포함하도록 배합하여 항균용 조성물을 제조하였다.An antibacterial composition was prepared by mixing a 3-laurylamino 1,2-propanediol compound represented by chemical formula 1 and a sodium dehydroacetate compound represented by chemical formula 2 in a weight ratio of 7:3.
제조예 2.Manufacturing example 2.
화학식 1로 표시되는 3-라우릴아미노 1,2-프로판디올 화합물과, 화학식 2로 표시되는 카프릴히드록사믹산 화합물을 7:3의 중량비로 포함하도록 배합하여 항균용 조성물을 제조하였다.An antibacterial composition was prepared by mixing a 3-laurylamino 1,2-propanediol compound represented by chemical formula 1 and a caprylhydroxamic acid compound represented by chemical formula 2 in a weight ratio of 7:3.
제조예 3.Manufacturing example 3.
화학식 1로 표시되는 3-라우릴아미노 1,2-프로판디올 화합물과, 화학식 2로 표시되는 피록톤올아민 화합물을 7:3의 중량비로 포함하도록 배합하여 항균용 조성물을 제조하였다.An antibacterial composition was prepared by mixing a 3-laurylamino 1,2-propanediol compound represented by chemical formula 1 and a piroctone olamine compound represented by chemical formula 2 in a weight ratio of 7:3.
제조예 4.Manufacturing example 4.
화학식 1로 표시되는 3-라우릴아미노 1,2-프로판디올 화합물과, 화학식 2로 표시되는 라우로일 아르기닌 에틸에스터 화합물을 7:3의 중량비로 포함하도록 배합하여 항균용 조성물을 제조하였다.An antibacterial composition was prepared by mixing a 3-laurylamino 1,2-propanediol compound represented by chemical formula 1 and a lauroyl arginine ethyl ester compound represented by chemical formula 2 in a weight ratio of 7:3.
비교예 1~5Comparative examples 1-5
비교예 1.Comparative example 1.
화학식 1로 표시되는 화합물인 3-라우릴아미노-1,2-프로판디올(3-Laurylamino-1,2-propanediol) 화합물을 사용하였다.A compound, 3-Laurylamino-1,2-propanediol, represented by chemical formula 1, was used.
비교예 2.Comparative example 2.
화학식 2로 표시되는 화학식 2로 표시되는 소듐 디히드로아세테이트(Sodium dehydroacetate) 화합물을 사용하였다.A sodium dehydroacetate compound represented by chemical formula 2 was used.
비교예 3.Comparative example 3.
화학식 2로 표시되는 화학식 2로 표시되는 카프릴히드록사믹산(caprylhydroxamic acid) 화합물을 사용하였다.A caprylhydroxamic acid compound represented by chemical formula 2 was used.
비교예 4.Comparative example 4.
화학식 2로 표시되는 화학식 2로 표시되는 피록톤올아민(Piroctone olamine) 화합물을 사용하였다.A piroctone olamine compound represented by chemical formula 2 was used.
비교예 5.Comparative Example 5.
화학식 2로 표시되는 화학식 2로 표시되는 라우로일 아르기닌 에틸에스터(Lauroyl arginine ethyl ester) 화합물을 사용하였다.A compound of lauroyl arginine ethyl ester represented by chemical formula 2 was used.
실시예Example
하기 실시예에서 사용한 것들은 Sigma-Aldrich Korea 및 TCI 사 등으로부터 구입한 것을 사용하였다.The materials used in the examples below were purchased from Sigma-Aldrich Korea and TCI.
실시예 1 ~ 4 : 의류용 액체세제 조성물Examples 1 to 4: Liquid detergent composition for clothing
실시예 1.Example 1.
라우레스-7 6 중량%, 알킬벤젠술폰산염 3 중량%, 소듐라우레스-2 설페이트 5 중량%, 프로테아제 0.3 중량%, 리파아제 0.3 중량%, 코코지방산비누 1 중량%, 소금 2 중량%, 항료 0.2 중량%, 정제수 81.7 중량% 및 제조예 1에 따라 제조된 항균용 조성물 0.5 중량%을 포함한 의류용 액체 세제 조성물을 제조하였다.A liquid detergent composition for clothes was prepared, including 6 wt% of laureth-7, 3 wt% of alkylbenzene sulfonate, 5 wt% of sodium laureth-2 sulfate, 0.3 wt% of protease, 0.3 wt% of lipase, 1 wt% of coco fatty acid soap, 2 wt% of salt, 0.2 wt% of fragrance, 81.7 wt% of purified water, and 0.5 wt% of an antibacterial composition prepared according to Preparation Example 1.
실시예 2.Example 2.
제조예 1에 따라 제조된 항균용 조성물 대신에 제조예 2에 따라 제조된 항균용 조성물을 이용한 것을 제외하고는, 실시예 1에 기재된 방법과 동일한 방법으로 의류용 액체 세제 조성물을 제조하였다.A liquid detergent composition for clothing was prepared in the same manner as described in Example 1, except that the antimicrobial composition prepared in accordance with Manufacturing Example 2 was used instead of the antimicrobial composition prepared in accordance with Manufacturing Example 1.
실시예 3.Example 3.
제조예 1에 따라 제조된 항균용 조성물 대신에 제조예 3에 따라 제조된 항균용 조성물을 이용한 것을 제외하고는, 실시예 1에 기재된 방법과 동일한 방법으로 의류용 액체 세제 조성물을 제조하였다.A liquid detergent composition for clothing was prepared in the same manner as described in Example 1, except that the antimicrobial composition prepared in accordance with Manufacturing Example 3 was used instead of the antimicrobial composition prepared in accordance with Manufacturing Example 1.
실시예 4.Example 4.
제조예 1에 따라 제조된 항균용 조성물 대신에 제조예 4에 따라 제조된 항균용 조성물을 이용한 것을 제외하고는, 실시예 1에 기재된 방법과 동일한 방법으로 의류용 액체 세제 조성물을 제조하였다.A liquid detergent composition for clothing was prepared in the same manner as described in Example 1, except that the antimicrobial composition prepared in accordance with Manufacturing Example 4 was used instead of the antimicrobial composition prepared in accordance with Manufacturing Example 1.
실시예 5 ~ 8 : 주방용 세제 조성물Examples 5 to 8: Kitchen detergent composition
실시예 5.Example 5.
소듐라우레스-2 설페이트 5 중량%, 알파올레핀설페이트 4 중량%, 아민옥사이드 2 중량%, 알킬폴리글루코사이드 2 중량%, 알킬벤젠술폰산염 2 중량%, 글리세린 2 중량%, 항료 0.2 중량%, 정제수 82.5 중량% 및 제조예 1에 따라 제조된 항균용 조성물 0.3 중량%을 포함한 주방용 세제 조성물을 제조하였다.A kitchen detergent composition was prepared including 5 wt% of sodium laureth-2 sulfate, 4 wt% of alpha-olefin sulfate, 2 wt% of amine oxide, 2 wt% of alkyl polyglucoside, 2 wt% of alkyl benzene sulfonate, 2 wt% of glycerin, 0.2 wt% of a fragrance, 82.5 wt% of purified water, and 0.3 wt% of an antibacterial composition prepared according to Manufacturing Example 1.
실시예 6.Example 6.
제조예 1에 따라 제조된 항균용 조성물 대신에 제조예 2에 따라 제조된 항균용 조성물을 이용한 것을 제외하고는, 실시예 5에 기재된 방법과 동일한 방법으로 주방용 세제 조성물을 제조하였다.A kitchen detergent composition was prepared in the same manner as described in Example 5, except that the antimicrobial composition prepared in accordance with Manufacturing Example 2 was used instead of the antimicrobial composition prepared in accordance with Manufacturing Example 1.
실시예 7.Example 7.
제조예 1에 따라 제조된 항균용 조성물 대신에 제조예 3에 따라 제조된 항균용 조성물을 이용한 것을 제외하고는, 실시예 5에 기재된 방법과 동일한 방법으로 주방용 세제 조성물을 제조하였다.A kitchen detergent composition was prepared in the same manner as described in Example 5, except that the antimicrobial composition prepared in accordance with Manufacturing Example 3 was used instead of the antimicrobial composition prepared in accordance with Manufacturing Example 1.
실시예 8.Example 8.
제조예 1에 따라 제조된 항균용 조성물 대신에 제조예 4에 따라 제조된 항균용 조성물을 이용한 것을 제외하고는, 실시예 5에 기재된 방법과 동일한 방법으로 주방용 세제 조성물을 제조하였다.A kitchen detergent composition was prepared in the same manner as described in Example 5, except that the antimicrobial composition prepared in accordance with Manufacturing Example 4 was used instead of the antimicrobial composition prepared in accordance with Manufacturing Example 1.
실시예 9 ~ 12 : 물티슈 원액 조성물Examples 9 to 12: Water tissue original composition
실시예 9.Example 9.
천연추출물 1 중량%, 정제수 98.7 중량% 및 제조예 1에 따라 제조된 항균용 조성물 0.3 중량%을 포함한 물티슈 원액 조성물을 제조하였다.A wet tissue stock composition containing 1 wt% of a natural extract, 98.7 wt% of purified water, and 0.3 wt% of an antibacterial composition prepared according to Manufacturing Example 1 was prepared.
실시예 10.Example 10.
제조예 1에 따라 제조된 항균용 조성물 대신에 제조예 2에 따라 제조된 항균용 조성물을 이용한 것을 제외하고는, 실시예 9에 기재된 방법과 동일한 방법으로 물티슈 원액 조성물을 제조하였다.A wet tissue stock composition was prepared in the same manner as described in Example 9, except that the antibacterial composition prepared according to Manufacturing Example 2 was used instead of the antibacterial composition prepared according to Manufacturing Example 1.
실시예 11.Example 11.
제조예 1에 따라 제조된 항균용 조성물 대신에 제조예 3에 따라 제조된 항균용 조성물을 이용한 것을 제외하고는, 실시예 9에 기재된 방법과 동일한 방법으로 물티슈 원액 조성물을 제조하였다.A wet tissue stock composition was prepared in the same manner as described in Example 9, except that the antibacterial composition prepared in accordance with Manufacturing Example 3 was used instead of the antibacterial composition prepared in accordance with Manufacturing Example 1.
실시예 12.Example 12.
제조예 1에 따라 제조된 항균용 조성물 대신에 제조예 4에 따라 제조된 항균용 조성물을 이용한 것을 제외하고는, 실시예 9에 기재된 방법과 동일한 방법으로 물티슈 원액 조성물을 제조하였다.A wet tissue stock composition was prepared in the same manner as described in Example 9, except that the antibacterial composition prepared in accordance with Manufacturing Example 4 was used instead of the antibacterial composition prepared in accordance with Manufacturing Example 1.
실시예 13 ~ 16 : 샴푸 원액 조성물Examples 13 to 16: Shampoo concentrate composition
실시예 13.Example 13.
디소듐 이디티에이(Disodium EDTA) 0.05 중량%, 판테놀(Panthenol) 0.1 중량%, 글리세린 1 중량%, 토코페릴 아세테이트(Tocopheryl Acetate) 1 중량%, 폴리쿼터늄-7(PolyQuaternium-7) 0.5 중량%, 소튬 라우레스 설페이트(Sodium Laureth Sulfate) 8 중량%, 코카마이드 프로필 베타인(Cocamidopropyl Betaine) 5 중량%, 소튬 코코일 사코시네이트(Sodium Cocoyl Sarcosinate) 2 중량%, 폴리쿼터늄-10(PolyQuaternium-10) 0.5 중량%, 향료 1 중량%, 정제수 80.55 중량% 및 제조예 1에 따라 제조된 항균용 조성물 0.3 중량%을 포함한 샴푸 원액 조성물을 제조하였다.A shampoo stock composition was prepared including 0.05 wt% of disodium EDTA, 0.1 wt% of panthenol, 1 wt% of glycerin, 1 wt% of tocopheryl acetate, 0.5 wt% of polyquaternium-7, 8 wt% of sodium laureth sulfate, 5 wt% of cocamidopropyl betaine, 2 wt% of sodium cocoyl sarcosinate, 0.5 wt% of polyquaternium-10, 1 wt% of fragrance, 80.55 wt% of purified water, and 0.3 wt% of an antibacterial composition prepared according to Manufacturing Example 1.
실시예 14.Example 14.
제조예 1에 따라 제조된 항균용 조성물 대신에 제조예 2에 따라 제조된 항균용 조성물을 이용한 것을 제외하고는, 실시예 13에 기재된 방법과 동일한 방법으로 샴푸 원액 조성물을 제조하였다.A shampoo stock composition was prepared in the same manner as described in Example 13, except that the antimicrobial composition prepared according to Manufacturing Example 2 was used instead of the antimicrobial composition prepared according to Manufacturing Example 1.
실시예 15.Example 15.
제조예 1에 따라 제조된 항균용 조성물 대신에 제조예 3에 따라 제조된 항균용 조성물을 이용한 것을 제외하고는, 실시예 13에 기재된 방법과 동일한 방법으로 샴푸 원액 조성물을 제조하였다.A shampoo stock solution composition was prepared in the same manner as described in Example 13, except that the antimicrobial composition prepared according to Manufacturing Example 3 was used instead of the antimicrobial composition prepared according to Manufacturing Example 1.
실시예 16.Example 16.
제조예 1에 따라 제조된 항균용 조성물 대신에 제조예 4에 따라 제조된 항균용 조성물을 이용한 것을 제외하고는, 실시예 13에 기재된 방법과 동일한 방법으로 샴푸 원액 조성물을 제조하였다.A shampoo stock solution composition was prepared in the same manner as described in Example 13, except that the antimicrobial composition prepared according to Manufacturing Example 4 was used instead of the antimicrobial composition prepared according to Manufacturing Example 1.
실시예 17 ~ 20 : 화장품 크림 원액 조성물Examples 17 to 20: Cosmetic cream original composition
실시예 17.Example 17.
세토스테아릴알콜 2.5 중량%, 글리세릴스테아레이트 1.5 중량%, 트리옥타노인 5.0 중량%, 폴리솔베이트 60 1.2 중량%, 솔비탄스테아레이트 0.5 중량%, 스쿠알란 5.0 중량%, 유동 파라핀 3.0 중량%, 사이클로메치콘 3.0 중량%, 델타-토코페롤 0.2 중량%, 글리세린 4.0 중량%, 1,3-부틸렌글리콜 2.0 중량%, 잔탄검 0.2 중량%, EDTA-2Na 0.05 중량%, 향 0.1 중량%, 정제수 71.55 중량% 및 제조예 1에 따라 제조된 항균용 조성물 0.2 중량%을 포함한 크림 원액 조성물을 제조하였다.A cream stock composition was prepared including 2.5 wt% of cetostearyl alcohol, 1.5 wt% of glyceryl stearate, 5.0 wt% of trioctanoin, 1.2 wt% of polysorbate 60, 0.5 wt% of sorbitan stearate, 5.0 wt% of squalane, 3.0 wt% of liquid paraffin, 3.0 wt% of cyclomethicone, 0.2 wt% of delta-tocopherol, 4.0 wt% of glycerin, 2.0 wt% of 1,3-butylene glycol, 0.2 wt% of xanthan gum, 0.05 wt% of EDTA-2Na, 0.1 wt% of fragrance, 71.55 wt% of purified water, and 0.2 wt% of an antibacterial composition prepared according to Manufacturing Example 1.
실시예 18.Example 18.
제조예 1에 따라 제조된 항균용 조성물 대신에 제조예 2에 따라 제조된 항균용 조성물을 이용한 것을 제외하고는, 실시예 17에 기재된 방법과 동일한 방법으로 화장품 크림 원액 조성물을 제조하였다.A cosmetic cream stock composition was prepared in the same manner as described in Example 17, except that the antimicrobial composition prepared in accordance with Manufacturing Example 2 was used instead of the antimicrobial composition prepared in accordance with Manufacturing Example 1.
실시예 19.Example 19.
제조예 1에 따라 제조된 항균용 조성물 대신에 제조예 3에 따라 제조된 항균용 조성물을 이용한 것을 제외하고는, 실시예 17에 기재된 방법과 동일한 방법으로 화장품 크림 원액 조성물을 제조하였다.A cosmetic cream stock composition was prepared in the same manner as described in Example 17, except that the antimicrobial composition prepared in accordance with Manufacturing Example 3 was used instead of the antimicrobial composition prepared in accordance with Manufacturing Example 1.
실시예 20.Example 20.
제조예 1에 따라 제조된 항균용 조성물 대신에 제조예 4에 따라 제조된 항균용 조성물을 이용한 것을 제외하고는, 실시예 17에 기재된 방법과 동일한 방법으로 화장품 크림 원액 조성물을 제조하였다.A cosmetic cream stock composition was prepared in the same manner as described in Example 17, except that the antimicrobial composition prepared in accordance with Manufacturing Example 4 was used instead of the antimicrobial composition prepared in accordance with Manufacturing Example 1.
실시예 21 ~ 24 : 화장품 팩트 조성물Examples 21 to 24: Cosmetic pack composition
실시예 21.Example 21.
구상 파우더 (Silica-HDI) 25 중량%, 칼슘 알루미늄 보로실리케이트 10 중량%, 오일 바인더 실리콘 오일(Dimethicone) 20 중량%, 향료 0.2 중량%, 안료 5 중량%, 에탄올 20 중량%, 판상 파우더 탤크(Talc JA 46R) 19.4 중량% 및 제조예 1에 따라 제조된 항균용 조성물 0.4 중량%을 포함한 팩트 (고형 색조) 조성물을 제조하였다. A pack (solid color) composition was prepared including 25 wt% of spherical powder (Silica-HDI), 10 wt% of calcium aluminum borosilicate, 20 wt% of oil binder silicone oil (Dimethicone), 0.2 wt% of fragrance, 5 wt% of pigment, 20 wt% of ethanol, 19.4 wt% of platelet powder talc (Talc JA 46R), and 0.4 wt% of an antibacterial composition prepared according to Manufacturing Example 1.
실시예 22.Example 22.
제조예 1에 따라 제조된 항균용 조성물 대신에 제조예 2에 따라 제조된 항균용 조성물을 이용한 것을 제외하고는, 실시예 21에 기재된 방법과 동일한 방법으로 화장품 팩트 조성물을 제조하였다.A cosmetic pack composition was prepared in the same manner as described in Example 21, except that the antimicrobial composition prepared in accordance with Manufacturing Example 2 was used instead of the antimicrobial composition prepared in accordance with Manufacturing Example 1.
실시예 23.Example 23.
제조예 1에 따라 제조된 항균용 조성물 대신에 제조예 3에 따라 제조된 항균용 조성물을 이용한 것을 제외하고는, 실시예 21에 기재된 방법과 동일한 방법으로 화장품 팩트 조성물을 제조하였다.A cosmetic pack composition was prepared in the same manner as described in Example 21, except that the antimicrobial composition prepared in accordance with Manufacturing Example 3 was used instead of the antimicrobial composition prepared in accordance with Manufacturing Example 1.
실시예 24.Example 24.
제조예 1에 따라 제조된 항균용 조성물 대신에 제조예 4에 따라 제조된 항균용 조성물을 이용한 것을 제외하고는, 실시예 21에 기재된 방법과 동일한 방법으로 화장품 팩트 조성물을 제조하였다.A cosmetic pack composition was prepared in the same manner as described in Example 21, except that the antimicrobial composition prepared in accordance with Manufacturing Example 4 was used instead of the antimicrobial composition prepared in accordance with Manufacturing Example 1.
실험예Experimental example
상기 비교예 그리고 제조예 조성에 의해 제조된 각각의 항균용 조성물과, 실시예에 의해 제조된 각각의 화장품, 위생용품, 생활화학제품 조성물에 대하여 아래 방법과 같이 세균, 사상균 및 효모 각각에 대한 항균시험을 수행하였다.Antibacterial tests were performed on bacteria, mold, and yeast, respectively, for each antibacterial composition manufactured by the above comparative examples and manufacturing examples, and each cosmetic, hygiene product, and household chemical product composition manufactured by the examples, using the methods below.
[방법] 항균 시험[Method] Antibacterial test
시험용액에 대한 항균력 측정은 액체배지희석법(broth dilution method)을 이용하여 측정하였다. 시험용액의 처리농도를 최고농도 5%에서부터 최저농도 0.0001%가 되도록 희석하여 사용하였다. 시험용액과 균주를 함께 배양한 후 튜브의 혼탁도를 확인하였다. 이때 배지에 시험용액을 처리하지 않고, 균주만 접종한 튜브에서 보이는 혼탁정도에 비하여 시험용액을 농도별로 처리한 튜브 중 균의 성장이 보이지 않는 튜브의 시험용액의 농도를 최소억제 농도(MIC)로 정하였다. 위와 같은 1차 시험 후 시험용액의 처리농도를 좀 더 세분화해서 2자 시험을 진행해 정확한 최소억제농도(MIC)를 얻었다.The antibacterial activity of the test solution was measured using the broth dilution method. The test solution was diluted from a maximum concentration of 5% to a minimum concentration of 0.0001% and used. The test solution and the strain were cultured together, and the turbidity of the tube was checked. At this time, the concentration of the test solution in the tube where no bacterial growth was observed among the tubes treated with the test solution at different concentrations was determined as the minimum inhibitory concentration (MIC) compared to the turbidity shown in the tube where the strain was inoculated only without treating the test solution to the medium. After the first test as above, the test solution treatment concentration was further divided into two-party tests to obtain the accurate minimum inhibitory concentration (MIC).
1) 시험균의 전배양 1) Pre-culture of test bacteria
시험균주인 E. coli, S. aureus, P. aeruginosa 를 Tryptic Soy Broth에 접종하여 35±2℃에서 16-24시간 배양하였다. C. albicans는 Sabouraud Dextrose Broth에 접종하여 35℃에서 24시간 배양하였다. A. niger는 Potato dextrose agar에 도말하여 (25±1)℃에서 7일간 배양하였고, 균이 자란 고체 배지 위에 멸균생리식염수를 분주하고 spreader를 이용하여 포자를 떼어낸 후 멸균생리식염수에 희석하였다.The test strains, E. coli , S. aureus, and P. aeruginosa , were inoculated into Tryptic Soy Broth and cultured at 35±2℃ for 16-24 hours. C. albicans was inoculated into Sabouraud Dextrose Broth and cultured at 35℃ for 24 hours. A. niger was spread on potato dextrose agar and cultured at (25±1)℃ for 7 days. Sterile saline solution was dispensed onto the solid medium on which the bacteria had grown, and the spores were removed using a spreader and then diluted in sterile saline solution.
2) 시험용액의 조제2) Preparation of test solution
제조예 1 내지 4의 항균용 조성물을 디프로필렌글리콜(Dipropylene glycol)에 녹여 시험용액으로 사용하였다. The antibacterial compositions of Manufacturing Examples 1 to 4 were dissolved in dipropylene glycol and used as test solutions.
비교예 1 내지 5를 비교용액으로 사용하였다.Comparative examples 1 to 5 were used as comparative solutions.
3) 균주와 항균용 조성물(시험용액)의 혼합3) Mixing of strain and antibacterial composition (test solution)
튜브에 액체배지를 넣고 시험용액의 처리 농도를 최고농도 5%에서부터 최저농도 0.0001%가 되도록 희석하여 넣었다. 액체배지로 E. coli, S. aureus, P. aeruginosa(세균)는 Tryptic Soy Broth, C. albicans, A. niger(진균)는 Sabouraud Dextrose Broth)를 사용하였다.Liquid media was placed in the tube, and the test solution was diluted from the highest concentration of 5% to the lowest concentration of 0.0001%. Tryptic Soy Broth was used for E. coli, S. aureus, and P. aeruginosa (bacteria), and Sabouraud Dextrose Broth was used for C. albicans and A. niger (fungi).
4) 시험균액 접종4) Inoculation of test bacteria
E. coli, S. aureus, P. aeruginosa의 경우 테스트 튜브의 균주 농도가 1X105 CFU/mL 되도록 접종하였다. 시험용액의 처리가 완료된 tube는 35±2℃에서 16-24 시간 배양하였다. C. albicans, A. niger는 테스트 튜브의 균주 농도가 1X104 CFU/mL 되도록 접종하였다. 시험용액의 처리가 완료된 후 C. albicans는 35℃에서 24-48 시간, A. niger는 25℃에서 46-50 시간 동안 배양하였다. 균액을 넣지 않은 배지 tube를 음성 대조군(negative control)로 사용하였으며, 시험용액 없이 배지에 균액만 접종한 tube를 성장 대조군(growth control)로 사용하였다. 또한, 용매로 사용한 디프로필렌글리콜 자체가 가지는 항균력을 확인하기 위해 용매를 시료의 시험 조건과 동일하게 하여 용매에 대한 시험균의 MIC를 확인했다.For E. coli, S. aureus, and P. aeruginosa, the strain concentration in the test tube was 1X10 5 CFU/mL. The tubes treated with the test solution were cultured at 35±2℃ for 16-24 hours. C. albicans and A. niger were inoculated so that the strain concentration in the test tube was 1X10 4 CFU/mL. After treatment with the test solution , C. albicans was cultured at 35℃ for 24-48 hours, and A. niger was cultured at 25℃ for 46-50 hours. A medium tube without the inoculum was used as a negative control, and a tube inoculated with only the inoculum in the medium without the test solution was used as a growth control. In addition, in order to confirm the antibacterial activity of dipropylene glycol itself, which was used as a solvent, the MIC of the test bacteria for the solvent was confirmed under the same conditions as the test conditions of the sample.
[시험결과][Test Results]
시험 결과는 [표 1]~[표 8]에 나타내었으며, 시험결과를 통해 평가된 것과 같이 본 발명의 항균용 조성물, 본 발명의 항균용 조성물을 포함한 화장품, 위생용품, 생활화학제품 조성물들은 세균, 사상균, 효모를 효과적으로 제어함을 알 수 있었다.The test results are shown in [Table 1] to [Table 8], and as evaluated through the test results, it was found that the antibacterial composition of the present invention and the cosmetic, sanitary product, and household chemical product compositions including the antibacterial composition of the present invention effectively control bacteria, mold, and yeast.
구체적으로, 표 1은 비교예의 항균 효과를 나타낸 것이고, 표 2는 본 발명의 제조예에 따라 제조된 항균용 조성물의 세균, 사상균, 효모에 대한 항균 시험 결과를 나타낸 것이다.Specifically, Table 1 shows the antibacterial effects of comparative examples, and Table 2 shows the results of antibacterial tests on bacteria, mold, and yeast of antibacterial compositions manufactured according to manufacturing examples of the present invention.
표 1과 표 2를 참조하면, 본 발명에 따라 제조된 모든 항균용 조성물은 표 1의 단독 화합물에 비해, 세균, 사상균, 효모에 대해 우수한 항균 효과를 나타내었고, 특히, 제조예 4의 3-라우릴아미노-1,2-프로판디올 화합물 및 라우로일 아르기닌 에틸에스터 화합물을 조합한 항균용 조성물의 경우 세균(E.coli, S.Aureus, P.Aeruginosa), 사상균(A.niger), 효모(C.albicans) 모두 효과적으로 제어할 수 있음을 확인하였다.Referring to Tables 1 and 2, all antibacterial compositions manufactured according to the present invention exhibited superior antibacterial effects against bacteria, mold, and yeast compared to the individual compounds of Table 1, and in particular, it was confirmed that the antibacterial composition combining the 3-laurylamino-1,2-propanediol compound and the lauroyl arginine ethyl ester compound of Manufacturing Example 4 could effectively control bacteria ( E. coli, S. Aureus, P. Aeruginosa ), mold ( A. niger ), and yeast ( C. albicans ).
하기 표 3은 실시예 1 내지 4의 의류용 액체세제 조성물의 세균, 사상균, 효모에 대한 항균 시험 결과를 나타낸 것이다.Table 3 below shows the results of antibacterial tests on bacteria, mold, and yeast of the liquid detergent compositions for clothing of Examples 1 to 4.
표 3을 참조하면, 실시예 1 내지 4에 따른 의류용 액체세제 조성물의 경우 항균 시험 시 이용한 세균(E.coli, S.Aureus, P.Aeruginosa), 사상균(A.niger), 효모(C.albicans) 전부에 대해 효과적으로 제어할 수 있음을 확인하였다.Referring to Table 3, it was confirmed that the liquid detergent compositions for clothing according to Examples 1 to 4 could effectively control all of the bacteria ( E. coli, S. Aureus, P. Aeruginosa ), mold ( A. niger ), and yeast ( C. albicans ) used in the antibacterial test.
하기 표 4는 실시예 5 내지 8 의 주방용 세제 조성물의 세균, 사상균, 효모에 대한 항균 시험 결과를 나타낸 것이다.Table 4 below shows the results of antibacterial tests on bacteria, mold, and yeast of the kitchen detergent compositions of Examples 5 to 8.
표 4를 참조하면, 실시예 5 내지 8에 따른 주방용 세제 조성물의 경우 항균 시험 시 이용한 세균(E.coli, S.Aureus, P.Aeruginosa), 사상균(A.niger), 효모(C.albicans) 전부에 대해 효과적으로 제어할 수 있음을 확인하였다.Referring to Table 4, it was confirmed that the kitchen detergent compositions according to Examples 5 to 8 could effectively control all of the bacteria ( E. coli, S. Aureus, P. Aeruginosa ), mold ( A. niger ), and yeast ( C. albicans ) used in the antibacterial test.
하기 표 5는 실시예 9 내지 12의 물티슈 원액 조성물의 세균, 사상균, 효모에 대한 항균 시험 결과를 나타낸 것이다.Table 5 below shows the results of antibacterial tests on bacteria, mold, and yeast of the wet tissue original compositions of Examples 9 to 12.
표 5를 참조하면, 실시예 9 내지 12에 따른 물티슈 원액 조성물의 경우 항균 시험 시 이용한 세균(E.coli, S.Aureus, P.Aeruginosa), 사상균(A.niger), 효모(C.albicans) 전부에 대해 효과적으로 제어할 수 있음을 확인하였다.Referring to Table 5, it was confirmed that the wet tissue stock compositions according to Examples 9 to 12 could effectively control all bacteria ( E. coli, S. Aureus, P. Aeruginosa ), mold ( A. niger ), and yeast ( C. albicans ) used in the antibacterial test.
하기 표 6은 실시예 13 내지 16의 샴푸 원액 조성물의 세균, 사상균, 효모에 대한 항균 시험 결과를 나타낸 것이다.Table 6 below shows the results of antibacterial tests on bacteria, mold, and yeast of the shampoo concentrate compositions of Examples 13 to 16.
표 6을 참조하면, 실시예 13 내지 16에 따른 샴푸 원액 조성물의 경우 항균 시험 시 이용한 세균(E.coli, S.Aureus, P.Aeruginosa), 사상균(A.niger), 효모(C.albicans) 전부에 대해 효과적으로 제어할 수 있음을 확인하였다.Referring to Table 6, it was confirmed that the shampoo concentrate compositions according to Examples 13 to 16 could effectively control all bacteria ( E. coli, S. Aureus, P. Aeruginosa ), mold ( A. niger ), and yeast ( C. albicans ) used in the antibacterial test.
하기 표 7은 실시예 17 내지 20의 화장품 크림 원액 조성물의 세균, 사상균, 효모에 대한 항균 시험 결과를 나타낸 것이다.Table 7 below shows the results of antibacterial tests on bacteria, mold, and yeast of the cosmetic cream concentrate compositions of Examples 17 to 20.
표 7을 참조하면, 실시예 17 내지 20에 따른 화장품 크림 원액 조성물의 경우 항균 시험 시 이용한 세균(E.coli, S.Aureus, P.Aeruginosa), 사상균(A.niger), 효모(C.albicans) 전부에 대해 효과적으로 제어할 수 있음을 확인하였다.Referring to Table 7, it was confirmed that the cosmetic cream concentrate compositions according to Examples 17 to 20 could effectively control all bacteria ( E. coli, S. Aureus, P. Aeruginosa ), mold ( A. niger ), and yeast ( C. albicans ) used in the antibacterial test.
하기 표 8은 실시예 21 내지 24의 화장품 팩트 조성물의 세균, 사상균, 효모에 대한 항균 시험 결과를 나타낸 것이다.Table 8 below shows the results of antibacterial tests on bacteria, mold, and yeast of the cosmetic pack compositions of Examples 21 to 24.
표 8을 참조하면, 실시예 21 내지 24에 따른 화장품 팩트 조성물의 경우 항균 시험 시 이용한 세균(E.coli, S.Aureus, P.Aeruginosa), 사상균(A.niger), 효모(C.albicans) 전부에 대해 효과적으로 제어할 수 있음을 확인하였다.Referring to Table 8, it was confirmed that the cosmetic pack compositions according to Examples 21 to 24 could effectively control all of the bacteria ( E. coli, S. Aureus, P. Aeruginosa ), mold ( A. niger ), and yeast ( C. albicans ) used in the antibacterial test.
Claims (12)
(b) 화학식 2로 표시되는 화합물을 포함하는 것인 항균용 조성물:
[화학식 1]
[화학식 2]
상기 화학식 2에서,
L3 는 -C(=O)- 인 경우, R4 는 이고, X는 아무것도 아니고(Null),
L3 는 -(CH2)p- 인 경우, p 는 5 내지 12의 정수이고, R4 는 -C(=O)-NH-OH 또는 이고, X는 아무것도 아니고(Null),
L3 는 -C(CH3)2-CH2-CH(CH3)-CH2- 인 경우, R4 는 이며, X는 NH2-CH2-CH2-OH 임.
(a) a compound represented by chemical formula 1, and
(b) An antibacterial composition comprising a compound represented by chemical formula 2:
[Chemical Formula 1]
[Chemical formula 2]
In the above chemical formula 2,
If L 3 is -C(=O)-, R 4 is , and X is nothing (Null),
When L 3 is -(CH 2 ) p -, p is an integer from 5 to 12, and R 4 is -C(=O)-NH-OH or , and X is nothing (Null),
If L 3 is -C(CH 3 ) 2 -CH 2 -CH(CH 3 )-CH 2 -, then R 4 is , and X is NH 2 -CH 2 -CH 2 -OH.
상기 항균용 조성물은 대장균(Escherichia Coli), 황색포도상구균(Staphylococcus Aureus), 녹농균(Pseudomonas Aeruginosa), 아스퍼질러스 니제르(Aspergillus niger) 및 칸디다 알비칸스(Candida albicans)로 이루어진 군에서 선택된 적어도 하나 이상의 미생물을 제어하기 위한 것인 항균용 조성물.
In the first paragraph,
The above antimicrobial composition is an antimicrobial composition for controlling at least one microorganism selected from the group consisting of Escherichia Coli , Staphylococcus Aureus , Pseudomonas Aeruginosa , Aspergillus niger, and Candida albicans.
화학식 1로 표시되는 화합물과 화학식 2로 표시되는 화합물은 0.01:9.99 내지 9.99:0.01 의 중량비로 포함하는 것인, 항균용 조성물.
In the first paragraph,
An antibacterial composition comprising a compound represented by chemical formula 1 and a compound represented by chemical formula 2 in a weight ratio of 0.01:9.99 to 9.99:0.01.
상기 화학식 2로 표시되는 화합물은,
소듐 디히드로아세테이트(Sodium dehydroacetate);
카프릴히드록사믹산(caprylhydroxamic acid);
피록톤올아민(Piroctone olamine); 및
라우로일 아르기닌 에틸에스터(Lauroyl arginine ethyl ester)로 이루어진 군에서 선택된 하나 이상인 것을 특징으로 하는 항균용 조성물.
In the first paragraph,
The compound represented by the above chemical formula 2 is
Sodium dehydroacetate;
caprylhydroxamic acid;
Piroctone olamine; and
An antibacterial composition characterized by comprising at least one selected from the group consisting of lauroyl arginine ethyl ester.
A product comprising an antibacterial composition according to claim 1.
상기 제품은 화장품, 위생용품 또는 생활화학제품인 것을 특징으로 하는 제품.
In Article 6,
The above product is characterized as being a cosmetic, hygiene product or household chemical product.
상기 화장품은 용액, 현탁액, 유탁액, 페이스트, 겔, 크림, 팩트, 파우더, 비누, 계면활성제-함유 클린싱, 오일, 유탁액 파운데이션, 왁스 파운데이션 및 스프레이로 이루어진 군에서 선택된 어느 하나로 제형화된 것을 특징으로 하는 제품.
In Article 7,
The above cosmetic is a product characterized in that it is formulated as one selected from the group consisting of a solution, a suspension, an emulsion, a paste, a gel, a cream, a pact, a powder, a soap, a surfactant-containing cleansing, an oil, an emulsion foundation, a wax foundation, and a spray.
상기 위생용품은 식기세정제, 식기세척기용 세정제 및 물티슈로 이루어진 군에서 선택된 것인 제품.
In Article 7,
The above sanitary products are products selected from the group consisting of dishwashing detergents, dishwasher detergents and wet tissues.
상기 생활화학제품은 의류세탁세제, 주거공간세정제, 탈취제, 공기세정제, 실내방향제, 발향제, 다목적 세정제, 소독제, 및 제균제로 이루어진 군에서 선택되는 것인 제품.
In Article 7,
The above household chemical product is a product selected from the group consisting of clothing detergents, residential space cleaners, deodorizers, air cleaners, indoor air fresheners, fragrances, multipurpose cleaners, disinfectants, and sterilizers.
상기 항균용 조성물은 화장품, 위생용품 또는 생활화학제품에 대해 0.01 내지 10 중량%로 포함하는 것을 특징으로 하는제품.
In Article 7,
A product characterized in that the above antibacterial composition is contained in an amount of 0.01 to 10 wt% for cosmetics, hygiene products, or household chemical products.
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