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KR101421326B1 - 유방암 예후 예측을 위한 조성물 및 이를 포함하는 키트 - Google Patents

유방암 예후 예측을 위한 조성물 및 이를 포함하는 키트 Download PDF

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KR101421326B1
KR101421326B1 KR1020110029118A KR20110029118A KR101421326B1 KR 101421326 B1 KR101421326 B1 KR 101421326B1 KR 1020110029118 A KR1020110029118 A KR 1020110029118A KR 20110029118 A KR20110029118 A KR 20110029118A KR 101421326 B1 KR101421326 B1 KR 101421326B1
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박웅양
박애경
노동영
한원식
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Abstract

본 발명은 유방암의 예후 예측을 위한 마커 유전자의 발현수준을 측정하는 제제를 포함하는 유방암의 예후 예측용 조성물, 상기 조성물을 포함하는 유방암의 예후 예측용 키트, 상기 유방암의 예후 예측 마커를 이용하여 유방암의 재발 가능성을 비롯한 예후 예측에 필요한 정보를 제공하는 방법에 관한 것이다. 본 발명에 따른 유방암 재발의 예후 예측은 유방암 비재발군과 재발군에서 차등적으로 발현된 유전자들을 예후 예측 마커로 사용함으로써 수술 또는 항암 화학요법을 시술 받은 환자에게서 2년 이내에 유방암이 재발할 가능성을 정확하면서도 신속하게 예측할 수 있고, 그로 인해 재발 가능성이 높은 환자를 위한 적절한 치료법의 선발을 가능케 할 뿐만 아니라 환자의 생존율을 높이는데 크게 기여할 수 있다.

Description

유방암 예후 예측을 위한 조성물 및 이를 포함하는 키트{Composition for predicting prognosis of breast cancer and kit comprising the same}
본 발명은 유방암의 예후를 예측하기 위한 마커 유전자의 발현수준을 측정하는 제제를 포함하는 유방암의 예후 예측용 조성물, 상기 조성물을 포함하는 유방암의 예후 예측용 키트, 상기 마커 유전자의 발현수준을 측정하여 유방암의 예후를 예측하는데 필요한 정보를 제공하는 방법, 및 상기 마커 유전자에 의해 코딩되는 단백질에 시험물질을 처리하여 단백질의 활성을 촉진 또는 억제하는 시험물질을 유방암의 재발 억제제로 스크리닝하는 방법에 관한 것이다.
현재 한국의 여성들은 고칼로리 영양식, 저출산, 초산 연령, 모유 수유 기피 등으로 인해 유방암 재발률이 높아지고 있다. 우리나라 유방암 재발률은 40대에 40%로 최고에 달하며, 이후 50대, 30대, 60대, 70대, 20대 순으로 연령에 관계없이 발생한다. 하지만 개선된 검출방법, 집단 스크리닝(mass screening) 및 과거 십 년간에 걸친 치료방법의 발달로 유방암으로 진단된 여성의 생존률이 현저하게 증가하고 있다. 오늘날, 유방암 환자들 중 약 80%는 생존율이 가장 높은 질병의 초기 단계에 진단되고 있으며, 그 결과 유방암 환자의 약 85%는 진단 후 적어도 5년 이상 생존하는 것으로 나타났다.
이러한 진단기술의 발전에도 불구하고, 초기 단계에서 유방암으로 진단된 여성의 약 20%는 10년 후 예후가 나빠, 재발, 전이되거나 또는 이 기간 내에 사망하기도 한다. 그러나, 나머지 80%의 유방암 환자는 10년 후 예후가 우수하여, 추가적인 적극적 보조요법(예, 화학치료)을 요구하지 않는다. 즉, 초기 단계의 임파선-음성(node-negative) 유방암 환자들 중 적어도 일부는 보조적인 화학치료를 받아야 하지만, 환자에 대한 보다 적합한 치료를 위해서는 이들을 위험군별로 분류하여 치료하는 것이 요구된다.
실제로 초기 단계의 암환자 대다수는 수술 및/또는 방사선 치료 이후에 추가적인 치료가 없이도 장기간 생존하므로, 이러한 환자들 모두에게 적극적 보조요법을 추천하는 것은, 암의 화학치료와 관련된 상당한 부작용을 고려할 때 부적절한 것임에 틀림없다. 또한, 초기 단계의 유방암 환자 집단을 초기 진단으로 예후가 양호한 그룹과 양호하지 않은 그룹으로 구분하는 것은 임상학자들이 적합한 치료방법을 선정하는데 유용할 것이다. 따라서, 유방암, 특히 초기 단계의 유방암 환자의 예후를 평가하는 방법의 개발이 절실히 필요한 실정이다.
현재까지 상당수 연구는 유방암 예후를 분석하고 치료반응을 예측하기 위한 방법 및 인자의 동정에 집중되어 있다. 예후 표시자(indicator)는 종양 크기, 림프절 상태 및 조직학적 등급뿐만 아니라 예후에 대한 일부 정보를 제공하며 특정 치료제에 반응할 것 같은 분자 마커와 같은, 통상적인 많은 인자를 포함한다. 예컨대, 에스트로겐(ER) 및 프로게스테론(PR)의 스테로이드 호르몬 수용체 상태 측정법은 유방암 환자의 평가에 통상적으로 수행되는 과정이다(Fitzgibbons et al., Arch. Pathol. Lab. Med., 124: 966-978, 2000). 호르몬 수용체 양성인 종양은 호르몬 요법에 반응할 것임이 틀림없으며, 또한 전형적으로 보다 덜 적극적으로 증식하므로, ER+/PR+ 종양이 있는 환자의 예후는 보다 양호한 편이다.
또한, 인간 상피세포 성장인자 수용체 2(HER-2/neu)의 과다 발현은 양호하지 않은 유방암 예후와 관련성이 있다고 알려져 있다. 현재, 유방 종양에서의 Her2/neu 발현수준을 이용하여 항-Her-2/neu 항체 치료제인 트라스투주맙(trastuzumab)(Herceptin; Genentech)에 대한 반응을 예측하는 방법이 개발되어 있다. 또한, 유방암의 약 1/3은 종양 억제유전자 p53에 돌연변이가 있으며, 이러한 돌연변이는 질병의 공격성 증가 및 양호하지 않은 예후와 연관되어 있다고 알려져 있다. 또한, 비-히스톤성 핵 단백질로 세포 증식 마커인 Ki-67의 과다 발현은 유방암의 양호하지 않은 예후와 상관성이 있음이 입증되었다.
상기와 같은 예후 기준 및 분자 마커는 환자의 운명을 예측하고 적절한 치료방법을 선정하는데 일부 지침을 제공하지만, 유방암의 재발 및 예후, 특히 초기 단계의 유방암 환자를 평가하는 특이적이며 민감한 방법으로서는 부족하여 새로운 방법의 개발이 매우 필요한 실정이다. 이러한 방법은 예후가 양호한 유방암 환자와 예후가 양호하지 않은 유방암 환자를 특이적으로 식별할 수 있어야 하며, 적극적인 보조요법이 요구되는 초기 단계의 고위험도 유방암 환자를 식별할 수 있어야 한다. 하지만 현재까지 유방암에 대해 높은 예후를 정확하게 예측할 수 있는 마커나 방법은 개발되지 않았다.
이러한 배경 하에서, 본 발명자들은 유방암의 예후 예측, 특히 유방암 치료 후 재발 가능성 및 2년 생존 예후를 예측할 수 있는 마커를 개발하기 위해 예의 노력한 결과, 유방암 재발군과 비재발군에서 차등적으로 발현된 유전자를 탐색하고 이들 유전자의 변화 양상을 관찰하여 변화가 가장 많은 유전자를 마커 유전자로 발굴하였고, 이들 마커 유전자를 이용하면 외과적 수술 및/또는 항암 화학요법을 시술 받은 유방암 환자에서 2년 이내에 전신 또는 국소 재발에 대한 예후를 정확하게 판단할 수 있음을 확인하고 본 발명을 완성하였다.
본 발명의 목적은 유방암 재발군 및 비재발군에서 차등적으로 발현된 유전자들로 구성된 군으로부터 선택된 각각 5개 이상의 유전자의 mRNA 또는 이들 유전자에 의해 코딩되는 단백질의 발현수준을 측정하는 제제를 포함하는, 유방암의 예후 예측용 조성물을 제공하는 것이다.
본 발명의 다른 목적은 상기 조성물을 포함하는 유방암의 예후 예측용 키트를 제공하는 것이다.
본 발명의 또 다른 목적은 유방암 재발군 및 비재발군에서 차등적으로 발현된 유전자들로 구성된 군으로부터 선택된 각각 5개 이상의 유전자의 mRNA 또는 이들 유전자에 의해 코딩되는 단백질의 발현수준을 측정하는 단계를 포함하는, 유방암의 예후를 예측하는데 필요한 정보를 제공하는 방법을 제공하는 것이다.
본 발명의 다른 목적은 유방암 재발군 및 비재발군에서 차등적으로 발현된 유전자들로 구성된 군으로부터 선택된 각각의 유전자에 의해 코딩되는 단백질에 시험물질을 처리하여 단백질의 활성을 촉진 또는 억제하는 시험물질을 유방암의 재발 억제제로 스크리닝하는 방법에 관한 것이다.
하나의 양태로서, 본 발명은 유방암 재발군에서 차등적으로 발현이 증가된 서열번호: 1 내지 50의 염기서열을 갖는 유전자들 및 유방암 비재발군에서 차등적으로 발현이 증가된 서열번호: 51 내지 100의 염기서열을 갖는 유전자들로 구성된 군으로부터 선택된 각각 5개 이상의 유전자의 mRNA 또는 이들의 유전자에 의해 코딩되는 단백질의 발현수준을 측정하는 제제를 포함하는, 유방암의 예후 예측용 조성물에 관한 것이다.
바람직한 일 실시태양으로, 본 발명에 따른 유방암의 예후 예측용 조성물은 유방암 재발군에서 차등적으로 발현이 증가된 서열번호: 1 내지 50의 염기서열을 갖는 유전자들로부터 선택된 5개 이상의 유전자, 바람직하게는 10개 이상의 유전자, 더욱 바람직하게는 20개 이상의 유전자를 예후 마커 유전자로 선택하고, 유방암 비재발군에서 차등적으로 발현이 증가된 서열번호: 51 내지 100의 염기서열을 갖는 유전자들로부터 선택된 5개 이상의 유전자, 바람직하게는 10개 이상의 유전자, 더욱 바람직하게는 20개 이상의 유전자를 예후 마커 유전자로 선택하여, 상기 선택된 마커 유전자들의 mRNA 또는 이들 유전자에 의해 코딩되는 단백질의 발현수준을 측정하는 제제를 포함할 수 있다. 본 발명의 일 구현예에 따르면, 유방암 재발군 및 비재발군에서 차등적으로 발현이 증가된 각각의 유전자군으로부터 5개씩 단위로 개수를 증가시키면서 유전자를 선택한 후 다양한 알고리즘을 적용하여 예측율을 계산하였다.
본 발명에 따른 조성물에서 유방암의 예후 예측을 위한 마커 유전자로서, 서열번호: 1 내지 50의 염기서열을 갖는 유전자들은 유방암 치료 후 2년 이내에 유방암이 재발한 환자군에서 차등적으로 증가된 발현수준을 나타낸 유전자들로, 이들은 각각 SUV39H2(NM_024670), CDC20(NM_001255), CDC45L(NM_003504), CDCA5(NM_080668), CIT(NM_007174), ASF1B(NM_018154), FAM83D(NM_030919), MAD2L1(NM_002358), HJURP(NM_018410), NUP205(NM_015135), TRIP13(NM_004237), EZH2(NM_004456), TOP2A(NM_001067), UBE2C(NM_181802), NCAPH(NM_015341), BUB1B(NM_001211), CENPA(NM_001809), AURKA(NM_198433), NCAPG2(NM_017760), NEK2(NM_002497), C13orf3(NM_145061), PLK4(NM_014264), ORC6L(NM_014321), CDCA8(NM_018101), DEPDC1(NM_001114120), PTTG1(NM_004219), FOXM1(NM_202002), KIF2C(NM_006845), TTK(NM_003318), RRM2(NM_001034), GTSE1(NM_016426), IQGAP3(NM_178229), EXO1(NM_130398), CCNB2(NM_004701), RACGAP1(NM_013277), CHEK1(NM_001274), STIL(NM_001048166), KPNA2(NM_002266), CDC2(NM_001786), DLGAP5(NM_014750), CTPS(NM_001905), TMEM48(NM_018087), CCNA2(NM_001237), FEN1(NM_004111), CKS2(NM_001827), XRCC2(NM_005431), BUB1(NM_004336), MCM10(NM_182751), PLK1(NM_005030) 및 TPX2(NM_012112)이다. 상기 유전자들 중 5개 이상의 유전자의 mRNA 또는 이들 유전자에 의해 코딩되는 단백질의 발현수준이 정상 대조군에 비해 증가하는 경우에는, 유방암의 재발 가능성이 높고 생존 예후가 양호하지 않은 것으로 판단할 수 있다.
본 발명에 따른 조성물에서 유방암의 예후 예측을 위한 마커 유전자로서, 서열번호: 51 내지 100의 염기서열을 갖는 유전자들은 유방암 치료 후 2년 이내에 유방암이 재발하지 않은 환자군에서 차등적으로 증가된 발현수준을 나타낸 유전자들로, 이들은 각각 TLR4(NR_024168), MPEG1(NM_001039396), LRMP(NM_006152), MS4A6A(NM_152852), GIMAP4(NM_018326), DOCK2(NM_004946), AMICA1(NM_001098526), ARHGAP15(NM_018460), ITGA4(NM_000885), PIK3CG(NM_002649), AOAH(NM_001637), C17orf87(AY358809), FAM65B(NM_014722), ITGAL(NM_002209), EVI2B(NM_006495), HCLS1(NM_005335), PTPRC(NM_002838), CD3E(NM_000733), TLR7(NM_016562), CD4(NM_000616), CD53(NM_000560), LCP2(NM_005565), IGSF6(NM_005849), GPNMB(NM_001005340), CYBB(NM_000397), CD96(NM_198196), IL10RA(NM_001558), ALOX5(NM_000698), ARHGAP25(NM_014882), GPR174(NM_032553), FYB(NM_001465), CYTIP(NM_004288), CMKLR1(NM_004072), NCKAP1L(NM_005337), CD84(NM_003874), IL7R(NM_002185), PDCD1LG2(NM_025239), BTK(NM_000061), PRKCB(NM_002738), BIN2(NM_016293), CPVL(NM_019029), ITK(NM_005546), CD86(NM_175862), CD69(NM_001781), GZMK(NM_002104), SH2D1A(NM_002351), LIPA(NM_001127605), ACP5(NM_001111035), CTSS(NM_004079) 및 CD3G(NM_000073)이다. 상기 유전자들 중 5개 이상의 유전자의 mRNA 또는 이들 유전자에 의해 코딩되는 단백질의 발현수준이 정상 대조군에 비해 증가하는 경우에는, 유방암의 재발 가능성이 낮고 생존 예후가 양호한 것으로 판단할 수 있다.
본 발명에 따른 유방암의 예후 예측을 위한 마커로서 선발된 유전자들은 유방암 재발군과 비재발군 사이에 발현수준의 차이를 보이는 차등적으로 발현된 유전자들(differentially expressed genes, DEGs)이다. 즉, 본 발명은 서열번호: 1 내지 50의 염기서열을 갖는, 유방암 재발군에서 차등적으로 발현이 증가된 유전자들, 및 서열번호: 51 내지 100의 염기서열을 갖는, 유방암 비재발군에서 차등적으로 발현이 증가된 유전자들을 유방암의 예후 예측을 위한 마커 유전자로 규명하고, 이들의 발현수준을 측정함으로써 보다 정확하게 유방암의 예후를 예측할 수 있음을 확인하였다.
바람직한 실시태양으로, 본 발명은 유방암의 예후를 예측하기 위하여, 대상에게서 서열번호: 1 내지 50의 염기서열을 갖는 유전자들로부터 선택된 5개 이상의 유전자의 발현수준을 측정하여 증감여부를 확인한 후, 서열번호: 51 내지 100의 염기서열을 갖는 유전자들로부터 선택된 5개 이상의 유전자의 발현수준을 측정하여 증감여부를 확인함으로써 유방암의 예후를 정확하게 예측할 수 있다.
본 발명에 따른 유방암의 예후 예측을 위한 마커 유전자로서 서열번호 1 내지 100의 염기서열을 갖는 유전자들의 특징을 하기 표 1에 정리하였다.
유전자(NM) 유전자명 위치 logFC P.Value adj.P.Val SEQ ID NO
SUV39H2
(NM_024670)		 suppressor of variegation 3-9 homolog 2 (Drosophila) 10p13 0.9 0.000109 0.013111 1
CDC20
(NM_001255)		 cell division cycle 20 homolog (S. cerevisiae) 1p34.1 1.5 0.000122 0.013302 2
CDC45L
(NM_003504)		 CDC45 cell division cycle 45-like (S. cerevisiae) 22q11.21 1.1 0.000137 0.013875 3
CDCA5
(NM_080668)		 cell division cycle associated 5 11q12.1 1.2 0.000139 0.013875 4
CIT
(NM_007174)		 citron (rho-interacting, serine/threonine kinase 21) 12q24 1.1 0.000167 0.014793 5
ASF1B
(NM_018154)		 ASF1 anti-silencing function 1 homolog B (S. cerevisiae) 19p13.12 1.3 0.000192 0.015734 6
FAM83D
(NM_030919)		 family with sequence similarity 83, member D 20q11.22-q12 1 0.000227 0.016494 7
MAD2L1
(NM_002358)		 MAD2 mitotic arrest deficient-like 1 (yeast) 4q27 1.3 0.000244 0.017097 8
HJURP
(NM_018410)		 Holliday junction recognition protein 2q37.1 1.1 0.000258 0.017527 9
NUP205
(NM_015135)		 nucleoporin 205kDa 7q33 0.8 0.000293 0.017933 10
TRIP13
(NM_004237)		 thyroid hormone receptor interactor 13 5p15.33 1.4 0.000294 0.017933 11
EZH2
(NM_004456)		 enhancer of zeste homolog 2 (Drosophila) 7q35-q36 1.2 0.000295 0.017933 12
TOP2A
(NM_001067)		 topoisomerase (DNA) II alpha 170kDa 17q21-q22 1.8 0.000322 0.017994 13
UBE2C
(NM_181802)		 ubiquitin-conjugating enzyme E2C 20q13.12 1.3 0.000338 0.018163 14
NCAPH
(NM_015341)		 non-SMC condensin I complex, subunit H 2q11.2 1.3 0.000357 0.018606 15
BUB1B
(NM_001211)		 budding uninhibited by benzimidazoles 1 homolog beta (yeast) 15q15 1.4 0.000379 0.01908 16
CENPA
(NM_001809)		 centromere protein A 2p24-p21 0.9 0.000383 0.019114 17
AURKA
(NM_198433)		 aurora kinase A 20q13.2-q13.3 1.5 0.000405 0.019245 18
NCAPG2
(NM_017760)		 non-SMC condensin II complex, subunit G2 7q36.3 1 0.000412 0.019339 19
NEK2
(NM_002497)		 NIMA (never in mitosis gene a)-related kinase 2 1q32.2-q41 1.4 0.000448 0.019768 20
C13orf3
(NM_145061)		 chromosome 13 open reading frame 3 13q12.11 1.3 0.000471 0.019768 21
PLK4
(NM_014264)		 polo-like kinase 4 (Drosophila) 4q28 1.2 0.000501 0.020249 22
ORC6L
(NM_014321)		 origin recognition complex, subunit 6 like (yeast) 16q12 0.9 0.000569 0.021652 23
CDCA8
(NM_018101)		 cell division cycle associated 8 1p34.3 0.9 0.000572 0.021668 24
DEPDC1
(NM_001114120)		 DEP domain containing 1 1p31.2 1.7 0.000588 0.021753 25
PTTG1
(NM_004219)		 pituitary tumor-transforming 1 5q35.1 1.3 0.000649 0.02251 26
FOXM1
(NM_202002)		 forkhead box M1 12p13 1.6 0.000661 0.02251 27
KIF2C
(NM_006845)		 kinesin family member 2C 1p34.1 1.5 0.000664 0.02251 28
TTK
(NM_003318)		 TTK protein kinase 6q13-q21 1.7 0.000843 0.024926 29
RRM2
(NM_001034)		 ribonucleotide reductase M2 polypeptide 2p25-p24 1.2 0.000879 0.025674 30
GTSE1
(NM_016426)		 G-2 and S-phase expressed 1 22q13.2-q13.3 0.8 0.000931 0.025995 31
IQGAP3
(NM_178229)		 IQ motif containing GTPase activating protein 3 1q22-q23.1 1.1 0.000979 0.026534 32
EXO1
(NM_130398)		 exonuclease 1 1q42-q43 1.6 0.000997 0.02676 33
CCNB2
(NM_004701)		 cyclin B2 15q22.2 1.6 0.001031 0.027181 34
RACGAP1
(NM_013277)		 Rac GTPase activating protein 1 12q13.13 0.9 0.001038 0.027181 35
CHEK1
(NM_001274)		 CHK1 checkpoint homolog (S. pombe) 11q24-q24 1.3 0.00104 0.027181 36
STIL
(NM_001048166)		 SCL/TAL1 interrupting locus 1q32|1p32 1.2 0.001075 0.027725 37
KPNA2
(NM_002266)		 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) 17q24.2 1.1 0.001109 0.028145 38
CDC2
(NM_001786)		 cell division cycle 2, G1 to S and G2 to M 10q21.1 1.5 0.001144 0.028406 39
DLGAP5
(NM_014750)		 discs, large (Drosophila) homolog-associated protein 5 14q22.3 1.6 0.001203 0.028965 40
CTPS
(NM_001905)		 CTP synthase 1p34.1 0.8 0.001216 0.02913 41
TMEM48
(NM_018087)		 transmembrane protein 48 1p32.3 0.7 0.001316 0.030052 42
CCNA2
(NM_001237)		 cyclin A2 4q25-q31 1.3 0.0014 0.030769 43
FEN1
(NM_004111)		 flap structure-specific endonuclease 1 11q12 0.7 0.001424 0.030867 44
CKS2
(NM_001827)		 CDC28 protein kinase regulatory subunit 2 9q22 1.4 0.001444 0.03105 45
XRCC2
(NM_005431)		 X-ray repair complementing defective repair in Chinese hamster cells 2 7q36.1 1.1 0.001474 0.031266 46
BUB1
(NM_004336)		 budding uninhibited by benzimidazoles 1 homolog (yeast) 2q14 1.4 0.001498 0.031462 47
MCM10
(NM_182751)		 minichromosome maintenance complex component 10 10p13 1.4 0.001598 0.03249 48
PLK1
(NM_005030)		 polo-like kinase 1 (Drosophila) 16p12.1 1.5 0.001599 0.03249 49
TPX2
(NM_012112)		 TPX2, microtubule-associated, homolog (Xenopus laevis) 20q11.2 1.6 0.001738 0.0336 50
TLR4
(NR_024168)		 toll-like receptor 4 9q32-q33 -1 0.000332 0.018092 51
MPEG1
(NM_001039396)		 macrophage expressed 1 11q12.1 -1.2 0.00043 0.019656 52
LRMP
(NM_006152)		 lymphoid-restricted membrane protein 12p12.1 -0.9 0.000472 0.019768 53
MS4A6A
(NM_152852)		 membrane-spanning 4-domains, subfamily A, member 6A 11q12.1 -1 0.000475 0.019801 54
GIMAP4
(NM_018326)		 GTPase, IMAP family member 4 7q36.1 -0.9 0.000629 0.022299 55
DOCK2
(NM_004946)		 dedicator of cytokinesis 2 5q35.1 -1 0.000691 0.022952 56
AMICA1
(NM_001098526)		 adhesion molecule, interacts with CXADR antigen 1 11q23.3 -1.3 0.000911 0.025901 57
ARHGAP15
(NM_018460)		 Rho GTPase activating protein 15 2q22.2 -1 0.000946 0.026202 58
ITGA4
(NM_000885)		 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) 2q31.3 -0.8 0.001002 0.026826 59
PIK3CG
(NM_002649)		 phosphoinositide-3-kinase, catalytic, gamma polypeptide 7q22.3 -0.8 0.001157 0.028489 60
AOAH
(NM_001637)		 acyloxyacyl hydrolase (neutrophil) 7p14-p12 -1.2 0.001188 0.028773 61
C17orf87
(AY358809)		 chromosome 17 open reading frame 87 17p13.2 -1.2 0.001247 0.029474 62
FAM65B
(NM_014722)		 family with sequence similarity 65, member B 6p22.3-p21.32 -0.9 0.00126 0.029598 63
ITGAL
(NM_002209)		 integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 16p11.2 -1 0.001678 0.033234 64
EVI2B
(NM_006495)		 ecotropic viral integration site 2B 17q11.2 -1 0.00253 0.04097 65
HCLS1
(NM_005335)		 hematopoietic cell-specific Lyn substrate 1 3q13 -0.8 0.002678 0.041993 66
PTPRC
(NM_002838)		 protein tyrosine phosphatase, receptor type, C 1q31-q32 -1.1 0.002698 0.042066 67
CD3E
(NM_000733)		 CD3e molecule, epsilon (CD3-TCR complex) 11q23 -0.9 0.003016 0.04418 68
TLR7
(NM_016562)		 toll-like receptor 7 Xp22.3 -0.8 0.003378 0.046538 69
CD4
(NM_000616)		 CD4 molecule 12pter-p12 -0.9 0.003699 0.048633 70
CD53
(NM_000560)		 CD53 molecule 1p13 -0.9 0.004192 0.052033 71
LCP2
(NM_005565)		 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 5q33.1-qter -0.7 0.004244 0.052182 72
IGSF6
(NM_005849)		 immunoglobulin superfamily, member 6 16p12-p13 -1 0.004266 0.052356 73
GPNMB
(NM_001005340)		 glycoprotein (transmembrane) nmb 7p15 -0.8 0.004293 0.052359 74
CYBB
(NM_000397)		 cytochrome b-245, beta polypeptide Xp21.1 -0.9 0.004379 0.052975 75
CD96
(NM_198196)		 CD96 molecule 3q13.13-q13.2 -1 0.004698 0.054705 76
IL10RA
(NM_001558)		 interleukin 10 receptor, alpha 11q23 -0.9 0.004769 0.055159 77
ALOX5
(NM_000698)		 arachidonate 5-lipoxygenase 10q11.2 -0.7 0.004876 0.055816 78
ARHGAP25
(NM_014882)		 Rho GTPase activating protein 25 2p14 -0.8 0.004938 0.056224 79
GPR174
(NM_032553)		 G protein-coupled receptor 174 Xq21.1 -1.1 0.005814 0.060514 80
FYB
(NM_001465)		 FYN binding protein (FYB-120/130) 5p13.1 -0.9 0.006002 0.061532 81
CYTIP
(NM_004288)		 cytohesin 1 interacting protein 2q11.2 -1 0.006493 0.063824 82
CMKLR1
(NM_004072)		 chemokine-like receptor 1 12q24.1 -0.9 0.006602 0.064473 83
NCKAP1L
(NM_005337)		 NCK-associated protein 1-like 12q13.1 -0.9 0.007003 0.06609 84
CD84
(NM_003874)		 CD84 molecule 1q24 -0.9 0.00724 0.067186 85
IL7R
(NM_002185)		 interleukin 7 receptor 5p13 -1.3 0.007253 0.067186 86
PDCD1LG2
(NM_025239)		 programmed cell death 1 ligand 2 9p24.2 -0.8 0.008232 0.072233 87
BTK
(NM_000061)		 Bruton agammaglobulinemia tyrosine kinase Xq21.33-q22 -0.8 0.008351 0.072685 88
PRKCB
(NM_002738)		 protein kinase C, beta 16p11.2 -0.8 0.008561 0.07376 89
BIN2
(NM_016293)		 bridging integrator 2 12q13 -0.8 0.008992 0.075464 90
CPVL
(NM_019029)		 carboxypeptidase, vitellogenic-like 7p15-p14 -0.8 0.009325 0.076915 91
ITK
(NM_005546)		 IL2-inducible T-cell kinase 5q31-q32 -1 0.010571 0.081367 92
CD86
(NM_175862)		 CD86 molecule 3q21 -0.8 0.010905 0.082802 93
CD69
(NM_001781)		 CD69 molecule 12p13-p12 -1 0.01389 0.094682 94
GZMK
(NM_002104)		 granzyme K (granzyme 3; tryptase II) 5q11-q12 -1.3 0.013975 0.094887 95
SH2D1A
(NM_002351)		 SH2 domain protein 1A Xq25-q26 -0.9 0.016442 0.103285 96
LIPA
(NM_001127605)		 lipase A, lysosomal acid, cholesterol esterase 10q23.2-q23.3 -0.8 0.01649 0.103459 97
ACP5
(NM_001111035)		 acid phosphatase 5, tartrate resistant 19p13.3-p13.2 -0.9 0.017312 0.105921 98
CTSS
(NM_004079)		 cathepsin S 1q21 -0.8 0.017605 0.107052 99
CD3G
(NM_000073)		 CD3g molecule, gamma (CD3-TCR complex) 11q23 -0.9 0.018233 0.10899 100
따라서, 본 발명의 조성물은 유방암의 예후를 예측하기 위해, 서열번호: 1 내지 100의 염기서열을 갖는 유전자들의 mRNA 또는 이들 유전자에 의해 코딩되는 단백질의 발현수준을 측정하는 제제를 포함할 수 있다.
본 발명에서 용어, "차등적으로 발현된 유전자(differentially expressed genes, DEGs)"는 정상 또는 대조군 시료에서의 발현에 비하여, 질병, 구체적으로 암, 예를 들어 유방암 환자에서 그의 발현이 보다 높거나 보다 낮은 수준으로 활성화되는 유전자를 말한다. 이 용어는 또한 그의 발현이 동일한 질병의 상이한 병기에서 보다 높거나 보다 낮은 수준으로 활성화되는 유전자를 포함한다. 차등적으로 발현되는 유전자는 핵산 수준 또는 단백질 수준에서 활성화되거나 또는 억제될 수 있거나, 교대 스플라이싱을 통해 상이한 폴리펩티드 산물을 생성시킬 수 있음을 또한 알 수 있다. 이러한 차이는, 예를 들면 폴리펩티드의 mRNA 수준, 표면 발현, 분비 또는 다른 분배에 있어서의 변화에 의해 입증될 수 있다. 차등적인 유전자 발현은 2개 이상의 유전자 또는 이들의 유전자 산물간의 발현 비교, 또는 2개 이상의 유전자 또는 이들의 유전자 산물간의 발현 비율의 비교, 또는 동일한 유전자의 2개의 상이하게 처리된 산물의 비교(이들은 정상 대상과 질병, 구체적으로 유방암을 앓는 대상 사이에서 또는 동일한 질병의 다양한 병기 사이에서 다름)를 포함할 수 있다. 차등적인 발현은, 예를 들면 정상 세포와 질병에 걸린 세포들 사이에서, 또는 상이한 질병 사건 또는 질병 병기를 거치는 세포들 사이에서 유전자 또는 그의 발현 산물에서 일시적인 또는 세포 발현 양상의 정량적 및 정성적 차이를 모두 포함한다. 본 발명의 목적상, "차등적인 유전자 발현"은 정상 및 질병에 걸린 대상에서 또는 질병에 걸린 대상의 질병 발생의 다양한 병기에서 주어진 유전자의 발현 사이에 적어도 약 2배, 바람직하게는 적어도 약 4배, 보다 바람직하게는 적어도 약 6배, 가장 바람직하게는 적어도 약 10배의 차이가 있을 때 존재하는 것으로 간주된다.
본 발명에서 용어, "유방암"은 유방에 생긴 암세포로 이루어진 종괴를 의미하며, 일반적으로는 유방의 유관과 소엽에서 발생한 암을 의미한다. 예컨대, 유방암은 생검(biopsy)에 의해 악성 병리상태로 분류되는 상태로, 유방암 진단의 임상적인 기술은 의학 분야에 잘 알려져 있다. 당업자라면 유방암이, 예컨대 악성 종양 및 육종을 포함한, 유방 조직의 모든 악성을 나타냄을 이해할 것이다. 예시적으로, 유방암은 유방내암(ductal carcinoma in situ, DCIS), 상피내 소엽성 암종(lobular carcinoma in situ, LCIS), 점액성 유방암(mucinous carcinoma), 침윤성 관상피암(infiltrating ductal carcinoma, IDC), 침윤성 소엽내암(infiltrating lobular carcinoma, ILC) 등을 포함한다. 본 발명의 바람직한 실시예에 있어서, 목적 대상자는 실제 유방암으로 진단받아 수술 또는 항암 화학요법 등의 시술을 받은 인간 환자이다.
본 발명에서 용어, "예후"는 유방암과 같은 질환의, 예를 들어 재발, 전이성 확산, 및 약물 내성을 비롯한 유방암-기인성 사망 또는 진행의 가능성 등의 병의 경과 및 완치 여부를 의미한다. 본 발명의 목적상 예후는 유방암 치료 후 전신 또는 국소 재발 가능성을 의미하며, 바람직하게는 유방암의 수술 또는 항암 화학요법을 시술 받은 후 2년 이내에 전신 또는 국소 재발할 지의 여부를 예측하는 것을 의미한다.
본 발명에서 용어, "양호한 예후"는 암 환자, 특히 유방암 환자의 질병이 완치될 가능성을 의미하고, "양호하지 않은 예후"는 투병 중인 암 또는 종양의 재생(relapse) 또는 재발(recurrence), 전이 또는 사망할 가능성이 있음을 의미한다. 양호한 결과를 갖는 것으로 분류된 암 환자는 투병 중인 암 또는 종양이 없는 상태이다. 이와는 반대로, 양호하지 않은 결과의 암 환자는 질병의 재생, 종양 재발, 전이 또는 사망에 이른다. "양호한 예후"는 유방암 환자가 투병 중인 암 또는 종양이 적어도 2년, 보다 구체적으로는 적어도 5년 이상 동안 없는 상태로 있을 수 있음을 의미한다. 본 발명의 다른 측면에서, "양호하지 않은 예후"는 유방암 환자가 5년 미만, 보다 구체적으로는 2년 미만 이내에 질병 재생, 종양 재발, 전이 또는 사망을 경험할 수 있음을 의미한다.
본 발명에서 용어, "예측"이란 환자가 화학요법 또는 방사선 치료 등의 치료법에 대해 선호적으로 또는 비선호적으로 반응하여 환자가 치료, 예를 들어 특정 치료제, 및/또는 원발성 종양의 수술로 제거, 및/또는 암의 재발없이 특정 시기 동안 화학요법으로 치료된 후의 생존 여부 및/또는 가능성과 관련된다. 본 발명의 예측방법은 임의의 특정 환자에 대한 가장 적절한 치료방식을 선택하여 적용함으로써 임상적으로 사용될 수 있다. 본 발명의 예측방법은 환자가, 예를 들어 소정의 치료제 또는 조합물, 외과적 개입, 화학요법 등의 투여를 비롯한 소정의 치료 처방과 같은 치료법에 선호적으로 반응하는지를 확인하거나, 치료 처방 후 환자의 장기 생존 또는 전신 또는 국소 재발이 가능한지를 예측할 수 있다. 또한 이를 통하여 불필요한 보조 항암요법을 최소화하거나 전신 또는 국소 재발이 예측되는 환자에게는 더욱 효과적인 보조 항암요법을 사용할 수 있도록 계획할 수 있다.
본 발명에서 용어, "예후 예측용 조성물"은 유방암에 대한 치료 후 예후가 양호한 환자와 양호하지 않은 환자를 구별하여 재발 가능성을 예측할 수 있는 물질로, 정상 대조군에 비해 유방암 재발군 및 비재발군에서 발현수준의 증가 또는 감소를 보이는 폴리펩타이드 또는 핵산(예: mRNA 등), 지질, 당지질, 당단백 등과 같은 유기 생체분자 등을 예후 예측용 마커로서 포함한다.
본 발명에서 용어, "예후 예측용 마커", "예후 예측을 위한 마커" 또는 "예후 예측 마커(prognosis marker)"란 유방암 세포를 정상 세포와 구분하여 유방암 치료 후 재발 여부를 비롯한 예후를 예측할 수 있는 물질이다. 본 발명의 목적상 유방암 진단 후 수술 또는 화학요법을 시술받고 2년 이내에 전신 또는 국소 재발 여부를 결정하여 예후가 양호한 환자와 양호하지 않은 환자를 구별할 수 있는 마커를 의미한다.
유의성 있는 예후 예측 마커의 선택과 적용은 예후 예측 결과의 신뢰도를 결정짓는다. "유의성 있는 예후 예측 마커"란, 예후 예측하여 얻은 결과가 정확하여 타당도(validity)가 높고 반복 측정 시에도 일관된 결과를 나타내도록 신뢰도(reliability)가 높은 마커를 의미한다. 본 발명에 따른 유방암의 예후 예측 마커는, 유방암의 전신 또는 국소 재발과 함께 직접적 또는 간접적 요인으로 발현이 항상 증가하거나 감소하는 유전자들로서, 반복된 실험에도 동일한 결과를 나타낸다. 또한, 이들은 발현수준의 차이가 대조군과 비교할 때 매우 커서 잘못된 결과를 내린 확률이 거의 없는 신뢰도가 높은 마커들이다. 본 발명의 바람직한 실시예에 따르면, 다양한 알고리즘의 반복 실시를 통해 예견 정확성이 가장 높은 알고리즘을 선택하여 실시하였으며, 그 결과 유방암 재발군과 비재발군에서 차등적으로 발현된 유전자들로서 서열번호: 1 내지 100의 염기서열을 갖는 유전자들이 가장 신뢰도가 높은 것으로 선택되었다. 따라서, 본 발명의 유의성 있는 예후 예측 마커의 발현정도를 측정하여 얻은 결과를 토대로 예후 예측된 결과는 타당하게 신뢰할 수 있다.
본 발명에서 유방암의 예후 예측 마커로 선택된 상기 유전자들과 유방암 또는 이의 재발과의 관련성 및 유방암에 있어서 상기 유전자들의 구체적인 기능에 대해서는 현재까지 보고된 바 없다. 본 발명자들은 다음과 같은 과정을 통하여 상기 유전자들이 유방암의 예후 예측용 마커가 될 수 있음을 규명하였다.
본 발명자들은 유방암 수술 후 2년 이내에 전신 또는 국소 재발이 발생한 환자군과 발생하지 않은 환자군을 대상으로 각 환자군의 mRNA를 추출한 후 이를 mRNA 마이크로어레이(microarray)로 분석하였다. 유전자 네트워크 분석(network analysis)을 통해 허브 유전자(hub gene)를 선정하고, 선정된 허브 유전자 중 유방암 재발과 유의한 상관성을 보이는 유전자를 선택한 후 LOO(Leave-one-out) 교차 검증 방법에 따라 예측 알고리즘을 적용하였다. 그 결과, k-최근접 이웃(k-Nearest Neighbor, k-NN), 안정화 선형 판별 분석(Stabilized Linear Discriminant Analysis) 및 지지 벡터 머신(Support Vector Machines, SVM) 알고리즘을 적용하였을 때 전체 예측율이 89.1%로 가장 높게 나타났으며, 이 경우 재발 예측율은 97.1%로, 비재발 예측율 63.6%로 나타났다. 또한, 예측에 사용된 전사체 수를 10 내지 100개로 증가시켜도 k-최근접 이웃 알고리즘이나 지지 벡터 머신 알고리즘을 사용한 경우에는 예측율이 크게 달라지지 않는 것으로 나타났다(표 2 참고). 상기의 결과들을 종합하여, 유방암 재발군과 비재발군에서 차등적으로 발현된 유전자로서, 유방암의 재발 가능성을 예측할 수 있는 예후 마커 유전자로서 서열번호: 1 내지 100의 염기서열을 갖는 100개 유전자를 선발하였다(표 3 및 4 참고).
본 발명에서 용어, "유전자 또는 전사체(transcript)"는 혼용하여 사용될 수 있다.
본 발명에서 용어, "mRNA 발현수준 측정"은 유방암의 예후를 예측하기 위하여 생물학적 시료에서 마커 유전자의 mRNA 존재 여부와 발현정도를 확인하는 과정으로, mRNA의 양을 측정함으로써 알 수 있다. 이를 위한 분석방법으로는 RT-PCR, 경쟁적 RT-PCR(competitive RT-PCR), 실시간 RT-PCR(Real-time RT-PCR), RNase 보호 분석법(RPA; RNase protection assay), 노던 블랏팅(northern blotting), DNA 마이크로어레이 칩 등이 있으나, 이들로 한정되는 것은 아니다.
본 발명에 따른 유방암의 예후 마커 유전자의 mRNA 수준을 측정하는 제제는 바람직하게는 안티센스 올리고뉴클레오티드, 프라이머 쌍 또는 프로브이며, 상기 마커 유전자의 염기서열을 바탕으로 이들 유전자의 특정 영역을 특이적으로 증폭하는 프라이머 또는 프로브를 고안할 수 있다. 본 발명에 따른 유방암의 예후 마커 유전자의 염기서열은 유전자뱅크(GenBank)에 등록되어 당해분야에 공지된 상태이므로, 당업자는 상기 염기서열을 바탕으로 이들 유전자의 특정 영역을 특이적으로 증폭할 수 있는 프라이머 또는 프로브를 디자인할 수 있다.
본 발명에서 용어, "안티센스"는 안티센스 올리고머가 왓슨-크릭 염기쌍 형성에 의해 RNA 내의 표적 서열과 혼성화되어 표적 서열 내에서 전형적으로 mRNA와 헤테로이중체를 형성할 수 있는 뉴클레오티드 염기서열 및 서브유닛간 백본을 갖는 올리고머를 지칭한다. 올리고머는 표적 서열에 대한 정확한 서열 상보성 또는 유사 상보성을 가질 수 있다. 이 안티센스 올리고머는 mRNA의 번역을 차단 또는 저해하고 mRNA의 스플라이스 변이체를 생산하는 mRNA의 프로세싱 과정을 변화시킬 수 있다.
본 발명에서 용어, "프라이머"는 적절한 완충액 중의 적절한 조건(예를 들면, 4개의 다른 뉴클레오시드 트리포스페이트 및 DNA, RNA 폴리머라제 또는 역전사 효소와 같은 중합제) 및 적절한 온도 하에서 주형-지시 DNA 합성의 시작점으로서 작용할 수 있는 단일가닥 올리고뉴클레오티드를 말한다. 상기 프라이머의 적절한 길이는 사용 목적에 따라 달라질 수 있으나, 통상 15 내지 30개 뉴클레오티드이다. 짧은 프라이머 분자는 일반적으로 주형과 안정한 혼성체를 형성하기 위해서 더 낮은 온도를 필요로 한다. 프라이머 서열은 주형과 완전하게 상보적일 필요는 없으나, 주형과 혼성화할 정도로 충분히 상보적이어야 한다. 본 발명에서는 본 발명에 따른 유방암의 예후 마커 유전자에 대한 정방향 및 역방향 프라이머를 사용하여 PCR 증폭을 수행한 후 PCR 생성물의 증폭 여부를 통해 뇌종양의 재발 가능성 및 2년 생존 예후를 예측할 수 있다.
본 발명에서 용어, "프로브"는 mRNA와 특이적 결합을 이룰 수 있는 짧게는 수개 염기 내지 길게는 수백 개 염기에 해당하는 RNA 또는 DNA 등의 핵산 단편을 의미한다. 프로브는 올리고 뉴클레오티드 프로브, 단일가닥 DNA 프로브, 이중가닥 DNA 프로브, RNA 프로브 등의 형태로 제작될 수 있다. 본 발명에서는 본 발명에 따른 마커 유전자에 대해 상보적인 프로브를 이용하여 혼성화를 실시한 후, 혼성화 여부를 통해 유방암의 재발 여부를 비롯한 예후를 예측할 수 있다. 적당한 프로브의 선택 및 혼성화 조건은 당해분야에 공지된 것을 기초로 변형할 수 있다.
본 발명에 따른 안티센스 올리고뉴클레오티드, 프라이머 또는 프로브는 포스포르아미다이트 고체 지지체 방법을 비롯한 당해분야에 널리 공지된 방법을 사용하여 화학적으로 합성할 수 있다. 이러한 핵산 서열은 또한 당해분야에 공지된 많은 수단을 이용하여 변형시킬 수 있다. 이러한 변형의 비-제한적인 예로는 메틸화, 캡핑, 천연 뉴클레오티드 하나 이상의 동족체로의 치환, 및 뉴클레오티드간의 변형, 예를 들면, 하전되지 않은 연결체(예: 메틸포스포네이트, 포스포트리에스테르, 포스포로아미데이트, 카바메이트 등) 또는 하전된 연결체(예: 포스포로티오에이트, 포스포로디티오에이트 등)로의 변형이 있다.
본 발명에서 용어, "단백질의 발현수준 측정"은 유방암 재발 가능성을 예후 예측하기 위하여 생물학적 시료에서 마커 유전자로부터 코딩된 단백질의 존재 여부와 발현수준을 확인하는 과정으로, 상기 단백질에 대하여 특이적으로 결합하는 항체를 이용해 단백질의 양을 확인한다. 이를 위한 분석방법으로는 웨스턴 블랏팅(western blotting), ELISA(enzyme linked immunosorbent assay), 방사선면역분석법(radioimmunoassay), 방사면역확산법(radioimmunodiffusion), 오우크레로니(Ouchterlony) 면역확산법, 로케트(Rocket) 면역전기영동, 면역조직화학염색, 면역침전분석(immunoprecipitation assay), 보체고정분석(complete fixation assay), FACS, 단백질 칩(protein chip) 등이 있으나, 이들로 한정되는 것은 아니다.
본 발명에서 용어, "항체"는 당해분야에 공지된 용어로서, 항원성 부위에 대해서 지시되는 특이적인 단백질 분자를 의미한다. 본 발명의 목적상, 항체는 본 발명의 마커 유전자로부터 코딩된 단백질에 대해 특이적으로 결합하는 항체를 의미하며, 이러한 항체는 각 유전자를 통상적인 방법에 따라 발현벡터에 클로닝하여 상기 마커 유전자에 의해 코딩되는 단백질을 얻은 후, 얻어진 단백질로부터 통상적인 방법에 의해 제조될 수 있다. 여기에는 상기 단백질에서 만들어질 수 있는 펩티드 단편도 포함되며, 본 발명의 펩티드 단편으로는, 최소한 7개 아미노산, 바람직하게는 9개 아미노산, 더욱 바람직하게는 12개 이상의 아미노산을 포함한다. 본 발명의 항체는 그 형태가 특별히 제한되지 않으며, 다중클론 항체, 단일클론 항체 또는 항원 결합성을 갖는 것이라면 그것의 일부도 본 발명의 항체에 포함되고, 모든 면역글로불린 항체가 포함된다.
상기한 바와 같이 유방암의 예후 예측 마커 유전자가 규명되었으므로, 이를 이용하여 항체를 생성하는 것은 당업계에 널리 공지된 기술을 이용하여 용이하게 제조할 수 있다. 다중클론 항체는 상기한 유방암의 예후 예측 마커 유전자로부터 코딩되는 단백질 항원을 동물에 주사하고 동물로부터 채혈하여 항체를 포함하는 혈청을 수득하는 당해분야에 널리 공지된 방법에 의해 생산할 수 있다. 이러한 다중클론 항체는 염소, 토끼, 양, 원숭이, 말, 돼지, 소 개 등의 임의의 동물 종 숙주로부터 제조 가능하다. 단클론 항체는 당해분야에 널리 공지된 하이브리도마 방법(hybridoma method)(Kohler 및 Milstein, European Jounral of Immunology, 6: 511-519, 1976), 또는 파지 항체 라이브러리(Clackson et al, Nature, 352: 624-628, 1991; Marks et al, J. Mol. Biol., 222(58): 1-597, 1991) 기술을 이용하여 제조될 수 있다. 상기 방법으로 제조된 항체는 겔 전기영동, 투석, 염 침전, 이온교환 크로마토그래피, 친화성 크로마토그래피 등의 방법을 이용하여 분리, 정제할 수 있다.
나아가, 본 발명의 항체에는 인간화 항체 등의 재조합 항체도 포함된다. 본 발명에 사용되는 항체는 2개의 전체 길이의 경쇄 및 2개의 전체 길이의 중쇄를 가지는 완전한 형태뿐만 아니라 항체 분자의 기능적인 단편을 포함한다. 항체 분자의 기능적인 단편이란 적어도 항원 결합기능을 보유하고 있는 단편을 뜻하며, Fab, F(ab'), F(ab')2, Fv 등이 있다.
또 하나의 양태로서, 본 발명은 상기 유방암의 예후 예측용 조성물을 포함하는, 유방암의 예후 예측용 키트에 관한 것이다.
본 발명의 키트는 유방암 재발군에서 차등적으로 발현이 증가된 마커 유전자의 mRNA 발현수준 또는 단백질의 발현수준을 확인하여 검사 대상에게서 상기 마커 유전자의 과다 발현 여부를 확인하고, 유방암 비재발군에서 발현이 증가된 마커 유전자의 mRNA 발현수준 또는 단백질의 발현수준을 확인하여 검사 대상에게서 상기 마커 유전자의 과다 발현 여부를 확인함으로써 유방암의 재발 가능성을 예후 예측할 수 있다. 본 발명의 키트는 마커 유전자의 mRNA 발현수준 또는 단백질의 발현수준을 확인하여 마커를 검출함으로써 유방암 재발 가능성을 예후 예측할 수 있다. 본 발명의 마커 검출용 키트에는 유방암 재발 여부를 예후 예측할 수 있는 마커 유전자의 발현수준을 측정하기 위한 프라이머, 프로브, 또는 상기 마커 유전자로부터 코딩된 단백질을 선택적으로 인지하는 항체뿐만 아니라 분석에 적합한 1종 이상의 다른 구성성분 조성물, 용액 또는 장치가 포함될 수 있다.
구체적인 일례로서, 본 발명에서 상기 마커 유전자들의 mRNA 발현수준을 측정하기 위한 키트는 RT-PCR을 수행하는데 요구되는 필수요소를 포함하는 키트일 수 있다. RT-PCR 키트는 마커 유전자에 특이적인 각각의 프라이머 쌍 외에도 테스트 튜브 또는 다른 적절한 컨테이너, 반응 완충액, 데옥시뉴클레오티드(dNTPs), Taq-중합효소 및 역전사효소와 같은 효소, DNase, RNase 억제제, DEPC-물(DEPC-water), 멸균수 등을 포함할 수 있다.
또한, 본 발명의 키트는 본 발명에 따른 마커 유전자들 중의 하나 이상을 포함하는 유방암의 재발 가능성을 예후 예측하기 위한 마이크로어레이 형태일 수 있다. 상기 마이크로어레이는 DNA 또는 RNA 폴리뉴클레오티드 프로브를 포함하는 것일 수 있다. 상기 마이크로어레이는 본 발명에 따른 유방암의 예후 마커 유전자의 염기서열에 특이적인 프로브를 포함하는 것을 제외하고는 통상적인 마이크로어레이의 구성을 포함한다. 본 발명의 마이크로어레이는 본 발명에 따른 유방암의 예후 마커 유전자의 과다 발현을 검출하여 유방암의 재발 여부를 예후 예측하는데 유용한 정보를 제공할 수 있다.
본 발명에 따른 유방암의 예후 마커 유전자에 대한 프로브를 기판 상에 고정화하여 마이크로어레이를 제조하는 방법은 당해분야에 잘 알려져 있다. 예컨대, DNA 마이크로어레이는, 이들로 한정되는 것은 아니지만, 파이조일렉트릭(piezoelectric) 방식을 이용한 마이크로피펫팅(micropipetting) 또는 핀(pin) 형태의 스폿터(spotter)를 이용한 방법에 의해 본 발명에 따른 마커 유전자에 대한 프로브를 기판 상에 고정화시킬 수 있다. 본 발명의 마이크로어레이의 기판은 아미노-실란(amino-silane), 폴리-L-라이신(poly-L-lysine) 및 알데히드(aldehyde)로 이루어진 군에서 선택되는 활성기가 코팅된 것이 바람직하나, 이에 한정되는 것은 아니다. 또한 상기 기판은 슬라이드 글래스, 플라스틱, 금속, 실리콘, 나일론 막 및 니트로셀룰로스 막(nitrocellulose membrane)으로 이루어진 군에서 선택되는 것이 바람직하나, 이들로 한정되는 것은 아니다.
또한, 마이크로어레이 상에서의 핵산의 혼성화 및 혼성화 결과의 검출은 당해분야에 잘 알려져 있다. 상기 검출은 핵산 시료를 형광물질, 예를 들면, Cy3 및 Cy5와 같은 물질을 포함하는 검출가능한 신호를 발생시킬 수 있는 표지물질로 표지한 다음, 마이크로어레이 상에 혼성화하고 상기 표지물질로부터 발생하는 신호를 검출함으로써 혼성화 결과를 검출할 수 있다.
또한, 본 발명에서 상기 마커 유전자들로부터 코딩된 단백질의 발현수준을 측정하기 위한 키트는 항체의 면역학적 검출을 위하여 기재, 적당한 완충용액, 발색효소 또는 형광물질로 표지된 2차 항체, 발색기질 등을 포함할 수 있다. 상기에서 기재로는 니트로셀룰로오스 막, 폴리비닐 수지로 합성된 96-웰 플레이트, 폴리스틸렌 수지로 합성된 96-웰 플레이트, 유리로 된 슬라이드 글라스 등이 이용될 수 있고, 발색효소로는 퍼옥시다아제(peroxidase), 알칼라인 포스파타아제(alkaline phosphatase) 등이 사용될 수 있다. 또한, 형광물질로는 FITC, RITC 등이 사용될 수 있고, 발색기질로는 ABTS(2,2'-아지노-비스-(3-에틸벤조티아졸린-6-설폰산)), OPD(o-페닐렌디아민), TMB(테트라메틸 벤지딘) 등이 사용될 수 있다.
또 다른 하나의 양태로서, 본 발명은 유방암 재발군에서 차등적으로 발현이 증가된 유전자들 및 유방암 비재발군에서 차등적으로 발현이 증가된 유전자들로 구성된 군으로부터 선택된 각각 5개 이상의 유전자의 mRNA 또는 이들 유전자에 의해 코딩되는 단백질의 발현수준을 측정하는 단계를 포함하는, 유방암의 예후를 예측하는데 필요한 정보를 제공하는 방법에 관한 것이다.
본 발명에 따른 방법은,
1) 개체의 시료로부터 서열번호: 1 내지 50으로 구성된 군에서 선택된 5개 이상의 유전자의 mRNA 발현수준 또는 상기 유전자에 의해 코딩되는 단백질의 발현수준을 측정하는 단계;
2) 상기 유전자의 mRNA 발현수준 또는 단백질의 발현수준을 정상 대조군 시료의 발현수준과 비교하는 단계;
3) 정상 대조군 시료보다 증가된 발현수준을 나타내는 개체의 시료로부터 서열번호: 51 내지 100으로 구성된 군에서 선택된 5개 이상의 유전자의 mRNA 발현수준 또는 상기 유전자에 의해 코딩되는 단백질의 발현수준을 측정하는 단계;
4) 상기 유전자의 mRNA 발현수준 또는 단백질의 발현수준을 정상 대조군 시료의 발현수준과 비교하는 단계; 및
5) 정상 대조군 시료보다 감소된 발현수준을 나타내는 개체의 시료를 유방암의 재발 가능성이 높은 것으로 판정하는 단계를 포함할 수 있다.
상기 방법에서 단계 1) 내지 단계 4)은 상기에 기재된 바와 같은 순서대로 수행할 수도 있고, 단계 1) 및 3)을 동시에 수행한 후 이어서 단계 2) 및 4)를 동시에 수행할 수도 있다.
본 발명에서 용어, "개체의 시료"란 유방암에 대한 수술 및/또는 화학요법을 시술 받은 개체로부터 분리된 조직, 세포, 전혈, 혈청, 혈장, 타액, 객담, 뇌척수액 또는 뇨와 같은 시료 등을 포함하나, 이들로 한정되는 것은 아니다.
mRNA 발현수준을 측정하기 위한 분석방법으로는 역전사효소 중합효소반응, 경쟁적 역전사효소 중합효소반응, 실시간 역전사효소 중합효소반응, RNase 보호 분석법, 노던 블랏팅, DNA 마이크로어레이 칩 등이 있으나, 이들로 한정되는 것은 아니다.
상기 분석방법을 통하여, 정상 대조군 시료의 mRNA 발현수준과 유방암 재발 의심 개체에서의 mRNA 발현수준을 비교할 수 있고, 마커 유전자에서 mRNA로의 발현수준의 유의한 증감여부를 판단하여 유방암 재발 의심 개체의 실제 유방암 재발 여부를 예후 예측할 수 있다. mRNA 발현수준은, 바람직하게는 마커로 사용되는 유전자에 특이적인 프라이머를 이용하는 역전사효소 중합반응 또는 마커로 사용되는 유전자에 특이적인 프로브를 이용하는 DNA 마이크로어레이 칩을 이용하여 측정할 수 있다.
본 발명의 바람직한 실시예에 따르면, 마커 유전자에 특이적인 프라이머를 사용하여 역전사효소 중합반응을 수행한 후 생성물을 전기영동하여 밴드 패턴과 밴드의 두께를 확인함으로써 유방암의 예후 예측 마커로 사용되는 유전자의 mRNA 발현수준을 측정한 후 이를 정상 대조군의 발현수준과 비교함으로써 유방암의 재발 가능성을 간편하게 예후 예측할 수 있다. 이때, 서열번호: 1 내지 50의 유전자들 중 5개 이상의 유전자의 발현수준은 증가한 반면, 서열번호: 51 내지 100의 유전자들 중 5개 이상의 유전자의 발현수준은 감소한 경우에 유방암의 재발 가능성이 높은 것으로 예후 예측할 수 있다.
한편, DNA 마이크로어레이 칩은 상기 마커 유전자 또는 그 단편에 해당하는 핵산이 유리 같은 기판에 고밀도로 부착되어 있는 DNA 칩을 이용하는 것으로서, 시료에서 mRNA를 분리하고, 그 말단 또는 내부에 형광물질이 표지된 cDNA 프로브를 조제하여, DNA 칩에 혼성화시킨 다음 유방암 재발 가능성을 예후 예측할 수 있다.
구체적으로, DNA 마이크로어레이 칩을 이용한 분석방법은 하기의 단계를 포함할 수 있다.
1) 개체의 시료로부터 서열번호: 1 내지 50의 유전자들 중 5개 이상의 유전자 및 서열번호: 51 내지 100의 유전자들 중 5개 이상의 유전자 각각의 mRNA를 분리하는 단계;
2) 상기 개체의 시료에서 분리한 각각의 mRNA와 정상 대조군의 mRNA를 cDNA로 합성하면서 이들 각각을 다른 형광물질로 표지하는 단계;
3) 상기에서 다른 형광물질로 표지된 각각의 cDNA를 마커 유전자에 대한 프로브가 고정된 DNA 마이크로어레이 칩과 혼성화하는 단계; 및
4) 상기 혼성화된 DNA 마이크로어레이 칩을 분석하여 개체 시료에서의 마커 유전자의 발현수준을 정상 대조군의 발현수준과 비교하는 단계.
상기 방법은, 서열번호: 1 내지 50의 유전자들 중 5개 이상의 유전자의 mRNA 발현수준은 증가한 반면, 서열번호: 51 내지 100의 유전자들 중 5개 이상의 유전자의 mRNA 발현수준은 감소한 경우에, 유방암의 재발 가능성이 높은 것으로 예후 예측할 수 있다.
본 발명에 적합한 형광물질로 Cy3, Cy5, FITC(poly L-lysine-fluorescein isothiocyanate), RITC(rhodamine-B-isothiocyanate), 로다민(rhodamine) 등을 사용할 수 있으나, 이들로 한정되는 것은 아니다. 또한, DNA 마이크로어레이 칩은 36 k Human V4.0 OpArray 올리고마이크로어레이(Operon, Germany) 또는 전체 인간 게놈 올리고마이크로어레이(Whole human genome oligo microarray, Agilent, USA) 등을 사용할 수 있으나, 이들로 한정되는 것은 아니다.
단백질 발현수준을 측정하기 위한 분석방법으로는, 웨스턴 블랏팅, ELISA, 방사선면역분석법, 방사면역확산법, 오우크레로니(Ouchterlony) 면역확산법, 로케트 면역전기영동, 면역조직화학염색, 면역침전분석, 보체고정분석, FACS, 단백질 칩 등이 있으나, 이들로 한정되는 것은 아니다.
상기 분석방법을 통하여, 정상 대조군에서의 항원-항체 복합체의 형성량과 유방암 재발 의심 개체에서의 항원-항체 복합체의 형성량을 비교할 수 있고, 마커 유전자에서 단백질로의 발현수준의 유의한 증가여부를 판단하여, 유방암 재발 의심 개체의 실제 유방암 재발 가능성을 예후 예측할 수 있다.
본 발명에서 용어, "항원-항체 복합체"란 마커 단백질과 이에 특이적인 항체의 결합물을 의미하고, 항원-항체 복합체의 형성량은 검출 라벨(detection label)의 시그널의 강도를 통해서 정량적으로 측정 가능하다.
단백질 발현수준은, 예컨대 ELISA를 이용하여 측정할 수 있다. ELISA는 고체 지지체에 부착된 항원을 인지하는 표지된 항체를 이용하는 직접적 ELISA, 고체 지지체에 부착된 항원을 인지하는 항체의 복합체에서 포획 항체를 인지하는 표지된 항체를 이용하는 간접적 ELISA, 고체 지지체에 부착된 항체와 항원의 복합체에서 항원을 인지하는 표지된 또 다른 항체를 이용하는 직접적 샌드위치 ELISA, 고체 지지체에 부착된 항체와 항원의 복합체에서 항원을 인지하는 또 다른 항체와 반응시킨 후 이 항체를 인지하는 표지된 2차 항체를 이용하는 간접적 샌드위치 ELISA 등 다양한 ELISA 방법을 포함한다.
또한, 상기 마커에 대한 하나 이상의 항체를 이용한 웨스턴 블랏팅을 이용할 수 있다. 시료에서 전체 단백질을 분리하고, 이를 전기영동하여 단백질을 크기에 따라 분리한 다음, 니트로셀룰로즈 막으로 이동시켜 항체와 반응시킨다. 생성된 항원-항체 복합체의 양을 표지된 항체를 이용하여 확인하는 방법으로 유전자의 발현에 의해 생성된 단백질의 양을 확인하여 유방암의 재발 가능성을 예후 예측할 수 있다. 상기 검출방법은 유방암 비재발군에서의 마커 단백질의 발현수준과 유방암 재발 의심군에서의 마커 단백질의 발현수준을 조사하는 방법으로 이루어진다. mRNA 또는 단백질 수준은 상기한 마커 단백질의 절대적(예: ㎍/㎖) 또는 상대적(예: 시그널의 상대 강도) 차이로 나타낼 수 있다.
또한, 상기 마커에 대한 하나 이상의 항체를 이용한 면역조직화학염색을 실시할 수 있다. 유방암 재발 의심군으로부터 채취한 조직을 고정한 후 당해분야에 널리 공지된 방법으로 파라핀 포매 블록을 제조한다. 이들을 수 μm 두께의 절편으로 만들어 유리 슬라이드에 붙여 조직 절편 슬라이드를 제작한 후, 여기에 본 발명에 따른 마커 단백질에 특이적인 항체를 공지의 방법에 따라 반응시킨다. 이후, 반응하지 못한 항체는 세척하여 제거하고, 면역반응을 관찰하기 위한 발색시약으로 반응시켜 마커 단백질의 발현수준을 현미경 하에서 관찰할 수 있다.
또한, 상기 마커에 대한 하나 이상의 항체가 기판 위의 정해진 위치에 배열되어 고밀도로 고정화되어 있는 단백질 칩을 이용할 수 있다. 단백질 칩을 이용하여 시료를 분석하는 방법은, 시료에서 단백질을 분리하고, 분리한 단백질을 단백질 칩과 혼성화하여 항원-항체 복합체를 형성하고, 이를 판독하여 단백질의 존재 또는 발현수준을 확인함으로써 유방암의 재발 가능성을 예후 예측할 수 있다.
또 하나의 양태로서, 본 발명은 유방암 재발군에서 차등적으로 발현이 증가된 유전자들 및 유방암 비재발군에서 차등적으로 발현이 증가된 유전자들로 구성된 군으로부터 각각 선택된 유전자에 의해 코딩되는 단백질에 시험물질을 처리하여 단백질의 활성을 촉진 또는 억제하는 시험물질을 유방암의 재발 억제제로 스크리닝하는 방법에 관한 것이다.
구체적으로, 본 발명의 스크리닝 방법은,
1) 서열번호: 1 내지 50의 유전자들 중 하나 이상의 발현이 증가되고 서열번호: 51 내지 100의 유전자들 중 하나 이상의 발현이 감소된 세포와 시험물질을 접촉시키는 단계;
2) 상기 유전자의 mRNA 발현수준 또는 상기 유전자로부터 코딩되는 단백질의 발현수준을 측정하는 단계; 및
3) 시험물질 처리 세포의 발현수준을 미처리 세포의 발현수준과 비교하여 서열번호: 1 내지 50으로부터 선택된 유전자의 발현은 억제하면서 서열번호: 51 내지 100으로부터 선택된 유전자의 발현을 활성화시키는 시험물질을 스크리닝하는 단계를 포함할 수 있다.
상기에서 "시험물질(test agent)"은 임의의 물질(substance), 분자(molecule), 원소(element), 화합물(compound), 실재물(entity) 또는 이들의 조합을 포함한다. 예컨대, 이들로 한정되지는 않으나, 단백질, 폴리펩티드, 소 유기분자(small organic molecule), 다당류(polysaccharide), 폴리뉴클레오티드 등을 포함한다. 또한, 천연 산물(natural product), 합성 화합물 또는 화학 화합물 또는 2개 이상의 물질의 조합일 수도 있다. 달리 지시되지 않는 한, 제제, 물질 및 화합물은 호환성 있게(interchangeably) 사용할 수 있다.
본 발명의 방법으로 스크리닝되거나 동정될 수 있는 시험물질은 폴리펩티드, 베타-턴 미메틱(beta-turnmimetics), 다당류, 인지질, 호르몬, 프로스타글란딘, 스테로이드, 방향족 화합물, 헤테로사이클릭 화합물, 벤조디아제핀(benzodiazepines), 올리고머릭 N-치환 글리신(oligomeric N-substituted glycines), 올리고카르바메이트(oligocarbamates), 당류(saccharides), 지방산, 퓨린, 피리미딘 또는 이들의 유도체, 구조적 유사체 또는 조합을 포함한다. 상기 시험물질은 합성 또는 천연 화합물의 라이브러리를 포함하는 광범위하고 다양한 출처로부터 얻어질 수 있다. 바람직하게는, 상기 시험물질은 펩티드, 예컨대, 약 5 내지 30개, 바람직하게는 약 5 내지 20개, 보다 바람직하게는 약 7 내지 15개의 아미노산을 가지는 펩티드일 수 있다. 상기 펩티드는 천연적으로 생성되는 단백질, 랜덤 펩티드 또는 "바이어스화(biased)" 랜덤 펩티드의 절단물일 수 있다.
또한 상기 시험물질은 "핵산"일 수 있다. 핵산 시험물질은 천연적으로 생성되는 핵산, 랜덤 핵산, 또는 "바이어스화" 랜덤 핵산일 수 있다. 예컨대, 원핵 또는 진핵 게놈의 절단물을 위에서 기재한 바와 유사하게 사용될 수 있다.
또한 상기 시험물질은 "소분자"(예: 약 1,000 이하의 분자량을 갖는 분자)일 수 있다. 소분자를 스크리닝하기 위한 방법에는 바람직하게는 고속 분석 어세이(high throughput assay)가 적용될 수 있다.
상기에서 대상 유전자의 발현수준은 mRNA 및/또는 단백질 수준에서 상술한 바와 같은 방법, 예컨대 mRNA 발현수준은 역전사효소 중합효소반응, 경쟁적 역전사효소 중합효소반응, 실시간 역전사효소 중합효소반응, RNase 보호 분석법(RPA), 노던 블랏팅, DNA 마이크로어레이 칩 등에 의해, 단백질 발현수준은 웨스턴 블랏팅, ELISA, 방사선면역분석법, 방사면역확산법, 오우크레로니(Ouchterlony) 면역확산법, 로케트 면역전기영동, 면역조직화학염색, 면역침전분석, 보체고정분석, FACS, 단백질 칩 등에 의해 측정될 수 있다.
본 발명에 따른 유방암 재발의 예후 예측은 유방암 비재발군과 재발군에서 차등적으로 발현된 유전자들을 예후 예측 마커로 사용함으로써 수술 또는 항암 화학요법을 시술 받은 환자에게서 2년 이내에 유방암이 재발할 가능성을 정확하면서도 신속하게 예측할 수 있다. 따라서, 본 발명은 예후가 양호하지 않은 환자와 양호한 환자를 특이적으로 식별할 수 있고, 이를 통해 유방암의 재발 여부를 조기에 판단하여 적절한 치료법의 선발 및 적용을 가능케 함으로써 유방암 환자의 생존율을 높일 수 있다.
도 1은 본 발명에서 유방암 재발군과 비재발군에서 차등적으로 발현이 증가된 것으로 확인된 유방암 예후 예측 마커 유전자들의 히트맵(Heatmap)과 계층적 군집화(hierarchical clustering)를 나타낸 것이다.
도 2는 도 1에 따른 계층적 군집화의 통계적 유의성을 나타낸 것이다.
이하, 본 발명을 하기의 실시예에 의해 상세히 설명한다. 단, 하기 실시예는 본 발명을 예시하는 것일 뿐, 본 발명의 내용이 하기 실시예에 의해 한정되는 것은 아니다.
실시예 1: 유방암의 예후 예측을 위한 마커 유전자의 선발
1-1. 유방암 조직 및 임상자료 준비
서울대학교병원으로부터 유방암 수술 후 2년 이내에 전신 또는 국소 재발이 확정된 11명을 유방암 재발군으로 선정하고, 전신 또는 국소 재발이 발생하지 않은 35명을 유방암 비재발군으로 선정하여, 총 46명의 개체로부터 종양조직을 확보하였다. 이들의 임상자료는 서울대학교병원 기관심사위원회의 승인 하에 수집되고 분석하였다.
1-2. mRNA 분리 및 mRNA 마이크로어레이 분석
유방암 재발군과 비재발군으로부터 차등적으로 발현된 유전자(DEGs)를 검출하기 위하여, 유전자칩 인간 게놈 1.0 ST 어레이(GeneChip Human Gene 1.0 ST Array, Affymetrix)를 사용하였다. 유방암 재발군과 비재발군의 각 개체로부터 분리된 종양조직 시료에서 RT-PCR로 전체 RNA를 증폭한 후 증폭된 100 ng의 전체 RNA를 제조사의 프로토콜(Affymetrix Whole-Transcript(WT) Sense Target Labeling Protocol)에 따라 바이오틴(biotin)으로 표지하였다. 바이오틴으로 표지된 센스 DNA 5.5 ㎍을 유전자칩 인간 게놈 1.0 ST 어레이에 혼성화(hybridization)한 후 프로토콜에 따라 스트렙타비딘-피코에리트린(Streptavidin-phycoerythrin)과 바이오틴화 항-스트렙타비딘 항체(biotinylated anti-streptavidin antibody)를 사용하여 염색하고 스캐닝하였다.
1-3. 차등적으로 발현된 유전자의 알고리즘 분석
유방암의 재발 가능성 예측에 사용될 마커 전사체는 하기 2가지 방법을 사용하여 결정하였다.
먼저, 상기 실시예 <1-2>의 마이크로어레이 분석에서 얻어진 총 28,000여 개의 전사체 중에서 변이(variation)가 높은 순서대로 4,500여 개의 전사체를 선택한 후 전사체 네트워크 분석을 실시하여 허브 전사체를 선정하였다. 이어서, 중도 t-검정(moderated t-test)을 이용하여 대상 개체를 유방암 재발군과 비재발군으로 나누고 두 군에서 mRNA 발현수준에 차이가 있는지를 조사하였다. t-검정 결과에서 나온 p 값이 작은 순서대로(즉, 유의한 정도가 큰 순서대로) 전사체의 순위를 결정하였다. 이때, t-검정을 적용하기 전에 발현이 낮은 전사체(즉, 모든 환자 샘플에서 log2(intensity)가 6 미만인 경우)와 샘플간 발현의 차이가 없는 전사체(표준편차가 전체 전사체의 shorth 보다 작은 경우)는 제외하였다. 두 결과를 종합하여 허브 전사체로 선정된 전사체 중에서 재발과 높은 상관성을 보이는 전사체, 즉 t-검정 결과 p 값이 낮으면서 재발군과 비재발군 사이에 발현양의 차이(배수 변화)가 큰 전사체를 유방암의 재발 가능성 예측에 사용될 마커 전사체로 선택하였다.
선정된 전사체를 유방암 재발군에서 차등적으로 발현이 증가된 전사체와 유방암 비재발군에서 차등적으로 발현이 증가된 전사체로 나누고, 각 집단에서 p 값이 낮은 순서대로 순위를 결정하였다. 이어서, 가장 순위가 높은 전사체를 각 집단에서 5개의 전사체를 시작으로 해당 개수만큼 전사체를 증가시키며 LOO 교차 검증법(Leave one out cross-validation)을 사용하여 검증하였다. LOO 교차 검증법은 다음과 같다.
전체 환자 46명 중 1명을 선택하여 실험집합(test set)으로 설정하고 나머지 45명을 학습집합(training set)으로 설정하였다. 학습집합만을 대상으로 선택된 해당 개수의 전사체를 이용하여 기계 학습 알고리즘을 학습시킨 후 실험집합의 예후를 예측하였다. 이 과정을 돌아가며 46회 반복하면 각 환자의 예후 예측 결과를 얻을 수 있다. 이 결과를 통합하여 유방암의 재발 가능성에 대한 예측율을 계산하였다. 교차 검증은 다양한 감독하 기계 학습 알고리즘(supervised machine learning algorithm)을 적용하여 예견 정확성(prediction accuracy)이 가장 높은 알고리즘을 선택하였다. 본 실시예에 사용된 알고리즘은 다음과 같다:
k-최인접 이웃(k-Nearest Neighbor), 선형 판별 분석(Linear Discriminant Analysis, LDA), 대각선 선형 판별 분석(Diagonal Linear Discriminant Analysis), 랜덤 포레스트(Random Forest), 나이브 베이즈(naive Bayes), 신경망 분석(Neural Networks), 안정화 선형 판별 분석(Stabilized Linear Discriminant Analysis), 지지 벡터 머신(Support Vector Machines, SVM), 일반화 선형 모델(Generalized Linear Models, GLM), 반복 분할 및 회귀 트리(Recursive Partitioning and Regression Trees), 학습 벡터 양자화(Learning Vector Quantization), 및 부트스트랩 군집(Bootstrap aggregating)
1-4. 유방암 재발 예후 예측을 위한 마커 유전자의 선발
하기 표 2는 전체 대상 개체 46명의 자료를 이용하여 허브 전사체 탐색 및 중도 t-검정을 적용한 후 순위가 결정된 전사체를 해당되는 수만큼 선택하여 LOO 방법에 따라 예측 알고리즘을 적용한 결과이다.
Figure 112011023347016-pat00001
상기 표 2에 나타난 바와 같이, k-최인접 이웃, 안정화 선형 판별 분석 및 지지 벡터 머신(SVM) 알고리즘을 적용하였을 때 89.1%로 가장 높은 전체 예측율이 나타났으며, 이 경우 재발 예측율은 97.1%, 비재발 예측율은 63.6%로 나타났다. 상기 결과는 예측에 사용된 전사체의 개수에 따라 예측율이 크게 달라지지 않음을 알 수 있다.
알고리즘 분석 결과, 유방암 재발군에서 차등적으로 발현이 증가된 것으로 확인된 전사체를 하기 표 3에, 유방암 비재발군에서 차등적으로 발현이 증가된 것으로 확인된 전사체를 하기 표 4에 나타내었고, 이들의 히트맵(heatmap) 및 계층적 군집화를 도 1에 나타내었다. 도 2는 도 1에 나타낸 계층적 군집화의 통계적 유의성을 나타낸 것으로서, AU(approximately unbiased test) 및 BP(bootstrapping) 값을 도면과 함께 제시한 것이다.
Figure 112011023347016-pat00002
Figure 112011023347016-pat00003
<110> SNU R&DB Foundation <120> Composition for predicting prognosis of breast cancer and kit comprising the same <130> PA110230/KR <150> KR10-2010-28671 <151> 2010-03-30 <160> 100 <170> KopatentIn 1.71 <210> 1 <211> 3093 <212> DNA <213> Homo sapiens suppressor of variegation 3-9 homolog 2 (Drosophila) (SUV39H2) <400> 1 cggggccgag gcgcgaggag gtgaggctgg agcgcggccc cctcgccttc cctgttccca 60 ggcaagctcc caaggcccgg gcggcggggc cgtcccgcgg gccagccaga tggcgacgtg 120 gcggttcccc gcccgccgcg accccaactc cgggacgcac gctgcggacg cctatcctcc 180 cccaggccgc tgacccgcct ccctgcccgg ccggctcccg ccgcggagga tatggaatat 240 tatcttgtaa aatggaaagg atggccagat tctacaaata cttgggaacc tttgcaaaat 300 ctgaagtgcc cgttactgct tcagcaattc tctaatgaca agcataatta tttatctcag 360 gtaaagaaag gcaaagcaat aactccaaaa gacaataaca aaactttgaa acctgccatt 420 gctgagtaca ttgtgaagaa ggctaaacaa aggatagctc tgcagagatg gcaagatgaa 480 ctcaacagaa gaaagaatca taaaggaatg atatttgttg aaaatactgt tgatttagag 540 ggcccacctt cagacttcta ttacattaac gaatacaaac cagctcctgg aatcagctta 600 gtcaatgaag ctacctttgg ttgttcatgc acagattgct tctttcaaaa atgttgtcct 660 gctgaagctg gagttctttt ggcttataat aaaaaccaac aaattaaaat cccacctggt 720 actcccatct atgaatgcaa ctcaaggtgt cagtgtggtc ctgattgtcc caataggatt 780 gtacaaaaag gcacacagta ttcgctttgc atctttcgaa ctagcaatgg acgtggctgg 840 ggtgtaaaga cccttgtgaa gattaaaaga atgagttttg tcatggaata tgttggagag 900 gtaatcacaa gtgaagaagc tgaaagacga ggacagttct atgacaacaa gggaatcacg 960 tatctctttg atctggacta tgagtctgat gaattcacag tggatgcggc tcgatacggc 1020 aatgtgtctc attttgtgaa tcacagctgt gacccaaatc ttcaggtgtt caatgttttc 1080 attgataacc tcgatactcg tcttccccga atagcattgt tttccacaag aaccataaat 1140 gctggagaag agctgacttt tgattatcaa atgaaaggtt ctggagatat atcttcagat 1200 tctattgacc acagcccagc caaaaagagg gtcagaacag tatgtaaatg tggagctgtg 1260 acttgcagag gttacctcaa ctgaactttt tcaggaaata gagctgatga ttataatatt 1320 tttttcctaa tgttaacatt tttaaaaata catatttggg actcttatta tcaaggttct 1380 acctatgtta atttacaatt catgtttcaa gacatttgcc aaatgtatta ccgatgcctc 1440 tgaaaagggg gtcactgggt ctcatagact gatatgaagt cgacatattt atagtgctta 1500 gagaccaaac taatggaagg cagactattt acagcttagt atatgtgtac ttaagtctat 1560 gtgaacagag aaatgcctcc cgtagtgttt gaaagcgtta agctgataat gtaattaaca 1620 actgctgaga gatcaaagat tcaacttgcc atacacctca aattcggaga aacagttaat 1680 ttgggcaaat ctacagttct gtttttgcta ctctattgtc attcctgttt aatactcact 1740 gtacttgtat ttgagacaaa taggtgatac tgaattttat actgttttct acttttccat 1800 taaaacattg gcacctcaat gataaagaaa tttaaggtat aaaattaaat gtaaaaatta 1860 atttcagctt catttcgtat ttcgaagcaa tctagactgt tgtgatgagt gtatgtctga 1920 acctgtaatt cttaaaagac ttcttaatct tctagaagaa aaatctccga agagctctct 1980 ctagaagtcc aaaatggcta gccattatgc ttctttgaaa ggacatgata atgggaccag 2040 gatggttttt tggagtacca agcaagggga atggagcact ttaagggcgc ctgttagtaa 2100 catgaattgg aaatctgtgt cgagtacctc tgatctaaac ggtaaaacaa gctgcctgga 2160 gagcagctgt acctaacaat actgtaatgt acattaacat tacagcctct caatttcagg 2220 caggtgtaac agttcctttc caccagattt aatattttta tacttcctgc aggttcttct 2280 taaaaagtaa tctatatttt tgaactgata cttgttttat acataaattt tttttagatg 2340 tgataaagct aaacttggcc aaagtgtgtg cctgaattat tagacctttt tattagtcaa 2400 cctacgaaga ctaaaataga atatattagt tttcaaggga gtgggaggct tccaacatag 2460 tattgaatct caggaaaaac tattctttca tgtctgattc tgagatttct aattgtgttg 2520 tgaaaatgat aaatgcagca aatctagctt tcagtattcc taatttttac ctaagctcat 2580 tgctccaggc tttgattacc taaaataagc ttggataaaa ttgaaccaac ttcaagaatg 2640 cagcacttct taatctttag ctctttcttg ggagaagcta gactttattc attatattgc 2700 tatgacaact tcactctttc ataatatata ggataaattg tttacatgat tggaccctca 2760 gattctgtta accaaaattg cagaatgggg ggccaggcct gtgtggtggc tcacacctgt 2820 gatcccagca ctttgggagg ctgaggtagg aggatcacgt gaggtcggga gttcaagacc 2880 agcctggcca tcatggtgaa accctgtctc tactgaaaat acaaaaatta gccgggcgtg 2940 gtggcacacg cctgtagtcc cagctactca ggaggctgag gcaggagaat cacttgaatt 3000 caggaggcgg aggttgcagt gagccaagat cataccactg cactgcagcc tgagtgacac 3060 agtaagactg tctccaaaaa aaaaaaaaaa aaa 3093 <210> 2 <211> 1697 <212> DNA <213> Homo sapiens cell division cycle 20 homolog (S. cerevisiae) (CDC20) <400> 2 gaggcgtaag ccaggcgtgt taaagccggt cggaactgct ccggagggca cgggctccgt 60 aggcaccaac tgcaaggacc cctccccctg cgggcgctcc catggcacag ttcgcgttcg 120 agagtgacct gcactcgctg cttcagctgg atgcacccat ccccaatgca ccccctgcgc 180 gctggcagcg caaagccaag gaagccgcag gcccggcccc ctcacccatg cgggccgcca 240 accgatccca cagcgccggc aggactccgg gccgaactcc tggcaaatcc agttccaagg 300 ttcagaccac tcctagcaaa cctggcggtg accgctatat cccccatcgc agtgctgccc 360 agatggaggt ggccagcttc ctcctgagca aggagaacca gcctgaaaac agccagacgc 420 ccaccaagaa ggaacatcag aaagcctggg ctttgaacct gaacggtttt gatgtagagg 480 aagccaagat ccttcggctc agtggaaaac cacaaaatgc gccagagggt tatcagaaca 540 gactgaaagt actctacagc caaaaggcca ctcctggctc cagccggaag acctgccgtt 600 acattccttc cctgccagac cgtatcctgg atgcgcctga aatccgaaat gactattacc 660 tgaaccttgt ggattggagt tctgggaatg tactggccgt ggcactggac aacagtgtgt 720 acctgtggag tgcaagctct ggtgacatcc tgcagctttt gcaaatggag cagcctgggg 780 aatatatatc ctctgtggcc tggatcaaag agggcaacta cttggctgtg ggcaccagca 840 gtgctgaggt gcagctatgg gatgtgcagc agcagaaacg gcttcgaaat atgaccagtc 900 actctgcccg agtgggctcc ctaagctgga acagctatat cctgtccagt ggttcacgtt 960 ctggccacat ccaccaccat gatgttcggg tagcagaaca ccatgtggcc acactgagtg 1020 gccacagcca ggaagtgtgt gggctgcgct gggccccaga tggacgacat ttggccagtg 1080 gtggtaatga taacttggtc aatgtgtggc ctagtgctcc tggagagggt ggctgggttc 1140 ctctgcagac attcacccag catcaagggg ctgtcaaggc cgtagcatgg tgtccctggc 1200 agtccaatgt cctggcaaca ggagggggca ccagtgatcg acacattcgc atctggaatg 1260 tgtgctctgg ggcctgtctg agtgccgtgg atgcccattc ccaggtgtgc tccatcctct 1320 ggtctcccca ttacaaggag ctcatctcag gccatggctt tgcacagaac cagctagtta 1380 tttggaagta cccaaccatg gccaaggtgg ctgaactcaa aggtcacaca tcccgggtcc 1440 tgagtctgac catgagccca gatggggcca cagtggcatc cgcagcagca gatgagaccc 1500 tgaggctatg gcgctgtttt gagttggacc ctgcgcggcg gcgggagcgg gagaaggcca 1560 gtgcagccaa aagcagcctc atccaccaag gcatccgctg aagaccaacc catcacctca 1620 gttgtttttt atttttctaa taaagtcatg tctcccttca tgtttttttt ttaaaaaaaa 1680 aaaaaaaaaa aaaaaaa 1697 <210> 3 <211> 1938 <212> DNA <213> Homo sapiens cell division cycle 45 homolog (S. cerevisiae) (CDC45) <400> 3 gatttggcgg gagtcttgac cgccgccggg ctcttggtac ctcagcgcga gcgccaggcg 60 tccggccgcc gtggctatgt tcgtgtccga tttccgcaaa gagttctacg aggtggtcca 120 gagccagagg gtccttctct tcgtggcctc ggacgtggat gctctgtgtg cgtgcaagat 180 ccttcaggcc ttgttccagt gtgaccacgt gcaatatacg ctggttccag tttctgggtg 240 gcaagaactt gaaactgcat ttcttgagca taaagaacag tttcattatt ttattctcat 300 aaactgtgga gctaatgtag acctattgga tattcttcaa cctgatgaag acactatatt 360 ctttgtgtgt gacacccata ggccagtcaa tgtcgtcaat gtatacaacg atacccagat 420 caaattactc attaaacaag atgatgacct tgaagttccc gcctatgaag acatcttcag 480 ggatgaagag gaggatgaag agcattcagg aaatgacagt gatgggtcag agccttctga 540 gaagcgcaca cggttagaag aggagatagt ggagcaaacc atgcggagga ggcagcggcg 600 agagtgggag gcccggagaa gagacatcct ctttgactac gagcagtatg aatatcatgg 660 gacatcgtca gccatggtga tgtttgagct ggcttggatg ctgtccaagg acctgaatga 720 catgctgtgg tgggccatcg ttggactaac agaccagtgg gtgcaagaca agatcactca 780 aatgaaatac gtgactgatg ttggtgtcct gcagcgccac gtttcccgcc acaaccaccg 840 gaacgaggat gaggagaaca cactctccgt ggactgcaca cggatctcct ttgagtatga 900 cctccgcctg gtgctctacc agcactggtc cctccatgac agcctgtgca acaccagcta 960 taccgcagcc aggttcaagc tgtggtctgt gcatggacag aagcggctcc aggagttcct 1020 tgcagacatg ggtcttcccc tgaagcaggt gaagcagaag ttccaggcca tggacatctc 1080 cttgaaggag aatttgcggg aaatgattga agagtctgca aataaatttg ggatgaagga 1140 catgcgcgtg cagactttca gcattcattt tgggttcaag cacaagtttc tggccagcga 1200 cgtggtcttt gccaccatgt ctttgatgga gagccccgag aaggatggct cagggacaga 1260 tcacttcatc caggctctgg acagcctctc caggagtaac ctggacaagc tgtaccatgg 1320 cctggaactc gccaagaagc agctgcgagc cacccagcag accattgcca gctgcctttg 1380 caccaacctc gtcatctccc aggggccttt cctgtactgc tctctcatgg agggcactcc 1440 agatgtcatg ctgttctcta ggccggcatc cctaagcctg ctcagcaaac acctgctcaa 1500 gtcctttgtg tgttcgacaa agaaccggcg ctgcaaactg ctgcccctgg tgatggctgc 1560 ccccctgagc atggagcatg gcacagtgac cgtggtgggc atccccccag agaccgacag 1620 ctcggacagg aagaactttt ttgggagggc gtttgagaag gcagcggaaa gcaccagctc 1680 ccggatgctg cacaaccatt ttgacctctc agtaattgag ctgaaagctg aggatcggag 1740 caagtttctg gacgcactta tttccctcct gtcctaggaa tttgattctt ccagaatgac 1800 cttcttattt atgtaactgg ctttcattta gattgtaagt tatggacatg atttgagatg 1860 tagaagccat tttttattaa ataaaatgct tattttaggc tccgtcccca aaaaaaaaaa 1920 aaaaaaaaaa aaaaaaaa 1938 <210> 4 <211> 2599 <212> DNA <213> Homo sapiens cell division cycle associated 5 (CDCA5) <400> 4 gaaaagactc ggggttccga gggccgcaga ccgctagccc tacgtcactt ccgcttcctt 60 tcccgcaggg cgggtaattc gaacgttttt tgcagcgagt ggccttcccg gttggcgcgc 120 gcccggggcg gcggcgctgg aggagctcga gacggagcct aagttatgtc tgggaggcga 180 acgcggtccg gaggagccgc tcagcgctcc gggccaaggg ccccatctcc tactaagcct 240 ctgcggaggt cccagcggaa atcaggctct gaactcccga gcatcctccc tgaaatctgg 300 ccgaagacac ccagtgcggc tgcagtcaga aagcccatcg tcttaaagag gatcgtggcc 360 catgctgtag aggtcccagc tgtccaatca cctcgcagga gccctaggat ttcctttttc 420 ttggagaaag aaaacgagcc ccctggcagg gagcttacta aggaggacct tttcaagaca 480 cacagcgtcc ctgccacccc caccagcact cctgtgccga accctgaggc cgagtccagc 540 tccaaggaag gagagctgga cgccagagac ttggaaatgt ctaagaaagt caggcgttcc 600 tacagccggc tggagaccct gggctctgcc tctacctcca ccccaggccg ccggtcctgc 660 tttggcttcg aggggctgct gggggcagaa gacttgtccg gagtctcgcc agtggtgtgc 720 tccaaactca ccgaggtccc cagggtttgt gcaaagccct gggccccaga catgactctc 780 cctggaatct ccccaccacc cgagaaacag aaacgtaaga agaagaaaat gccagagatc 840 ttgaaaacgg agctggatga gtgggctgcg gccatgaatg ccgagtttga agctgctgag 900 cagtttgatc tcctggttga atgagatgca gtggggggtg cacctggcca gactctccct 960 cctgtcctgt acatagccac ctccctgtgg agaggacact tagggtcccc tcccctggtc 1020 ttgttacctg tgtgtgtgct ggtgctgcgc atgaggactg tctgcctttg agggcttggg 1080 cagcagcggc agccatcttg gttttaggaa atggggccgc ctggcccagc cactcactgg 1140 tgtcctgtct cttgtcgtcc tgtccttcct atctccccaa agtaccatag ccagtttcca 1200 gatgggccac agactgggga ggagaatcag tggcccagcc agaagttaaa gggctgaggg 1260 ttgaggtgag aggcacctct gctcttgttg ggaggggtgg ctgcttggaa ataggcccag 1320 gggctctgcc agcctcggcc tctccctcct gagttgcctt ctgttggtgg ctttcttctt 1380 gaacccacct gtgtaaagag gttttcagtt ccgtgggttt cccctttgat tctgtaaata 1440 gtcccagaga gaattcgtgg gctgagggca attctgtctt ggaggaagaa gctggacatt 1500 cagcctgtgg agtctgagtt ttgaaggatg tagggagcct tagttgggtc tcagaccata 1560 agtgtgtact acacagaagc tgtgttttct agttctggtc tgctgttgag atgtttggta 1620 aatgccaggt tgatagggcg ctggctgctt ggagcaaagg gtgcatttca gggtgtggcc 1680 accaggtgct gtgagtttct gtggctcatg gcctctgggc tggtcccttg cacagggccc 1740 acgctggagt cttaccactc tgctgcaggg gtggaaggtg gcccctcttg tcacccatac 1800 ccatttctta caaaataagt tacaccgagt ctacttggcc ctagaagaga aagttgaaga 1860 gtcccagacc tactagcatt ttgcaactat gcttgtaaag tcctcggaaa gtttcctcgc 1920 gtaccagaca gcggcggggg ctgatagcaa ttttagtttt tggcctccct atcctctcac 1980 atgagaacac tgcctggatg catctcatga tctctggaga atttccccat ctttctcttc 2040 tttccatcgt gtggattcaa tagtgtggat ttgaaggctg ccctgccccc gactctcctg 2100 ccgcacccct ggccattgta ccttttgatg tttagaagtt cgtggaagta gacgctgagg 2160 tgtgcagagg agctggtgga taacagagaa tgccagggaa gatgagtgct gggtcagggt 2220 acttggatga aacggtgcag gccaggcggg ccctaataaa accctctgcc aggtctggga 2280 gtcccaggcc atctgctcaa cgctctgtgg tttgtcagac ctgcaagcaa gccccctgct 2340 ggggaagcct aggtgtcctt gagctgaacc gcactgaaga actcttgtcc tcactggctg 2400 atgcagcaga actcttggga aatgtcttag tcctgcagaa tcaggagtca ccagatgatg 2460 cagagttgag atcatcattg caaagttctc tgttcctgag gaactaaatt taaggaaaaa 2520 atgggatttt gttttagagt tggaaaaaaa gcctgattaa agagtttctg cctgttaaaa 2580 aaaaaaaaaa aaaaaaaaa 2599 <210> 5 <211> 8576 <212> DNA <213> sapiens citron (rho-interacting, serine/threonine kinase 21) (CIT) <400> 5 gcggggcgga acagatcgca gacctggggg ttcgcagagc cgccagtggg gagatgttga 60 agttcaaata tggagcgcgg aatcctttgg atgctggtgc tgctgaaccc attgccagcc 120 gggcctccag gctgaatctg ttcttccagg ggaaaccacc ctttatgact caacagcaga 180 tgtctcctct ttcccgagaa gggatattag atgccctctt tgttctcttt gaagaatgca 240 gtcagcctgc tctgatgaag attaagcacg tgagcaactt tgtccggaag tattccgaca 300 ccatagctga gttacaggag ctccagcctt cggcaaagga cttcgaagtc agaagtcttg 360 taggttgtgg tcactttgct gaagtgcagg tggtaagaga gaaagcaacc ggggacatct 420 atgctatgaa agtgatgaag aagaaggctt tattggccca ggagcaggtt tcattttttg 480 aggaagagcg gaacatatta tctcgaagca caagcccgtg gatcccccaa ttacagtatg 540 cctttcagga caaaaatcac ctttatctgg tcatggaata tcagcctgga ggggacttgc 600 tgtcactttt gaatagatat gaggaccagt tagatgaaaa cctgatacag ttttacctag 660 ctgagctgat tttggctgtt cacagcgttc atctgatggg atacgtgcat cgagacatca 720 agcctgagaa cattctcgtt gaccgcacag gacacatcaa gctggtggat tttggatctg 780 ccgcgaaaat gaattcaaac aagatggtga atgccaaact cccgattggg accccagatt 840 acatggctcc tgaagtgctg actgtgatga acggggatgg aaaaggcacc tacggcctgg 900 actgtgactg gtggtcagtg ggcgtgattg cctatgagat gatttatggg agatccccct 960 tcgcagaggg aacctctgcc agaaccttca ataacattat gaatttccag cggtttttga 1020 aatttccaga tgaccccaaa gtgagcagtg actttcttga tctgattcaa agcttgttgt 1080 gcggccagaa agagagactg aagtttgaag gtctttgctg ccatcctttc ttctctaaaa 1140 ttgactggaa caacattcgt aactctcctc cccccttcgt tcccaccctc aagtctgacg 1200 atgacacctc caattttgat gaaccagaga agaattcgtg ggtttcatcc tctccgtgcc 1260 agctgagccc ctcaggcttc tcgggtgaag aactgccgtt tgtggggttt tcgtacagca 1320 aggcactggg gattcttggt agatctgagt ctgttgtgtc gggtctggac tcccctgcca 1380 agactagctc catggaaaag aaacttctca tcaaaagcaa agagctacaa gactctcagg 1440 acaagtgtca caagatggag caggaaatga cccggttaca tcggagagtg tcagaggtgg 1500 aggctgtgct tagtcagaag gaggtggagc tgaaggcctc tgagactcag agatccctcc 1560 tggagcagga ccttgctacc tacatcacag aatgcagtag cttaaagcga agtttggagc 1620 aagcacggat ggaggtgtcc caggaggatg acaaagcact gcagcttctc catgatatca 1680 gagagcagag ccggaagctc caagaaatca aagagcagga gtaccaggct caagtggaag 1740 aaatgaggtt gatgatgaat cagttggaag aggatcttgt ctcagcaaga agacggagtg 1800 atctctacga atctgagctg agagagtctc ggcttgctgc tgaagaattc aagcggaaag 1860 cgacagaatg tcagcataaa ctgttgaagg ctaaggatca agggaagcct gaagtgggag 1920 aatatgcgaa actggagaag atcaatgctg agcagcagct caaaattcag gagctccaag 1980 agaaactgga gaaggctgta aaagccagca cggaggccac cgagctgctg cagaatatcc 2040 gccaggcaaa ggagcgagcc gagagggagc tggagaagct gcagaaccga gaggattctt 2100 ctgaaggcat cagaaagaag ctggtggaag ctgaggagct cgaagagaaa catcgggagg 2160 cccaagtctc agcccagcac ctagaagtgc acctgaaaca gaaagagcag cactatgagg 2220 aaaagattaa agtgttggac aatcagataa agaaagacct ggctgacaag gagacactgg 2280 agaacatgat gcagagacac gaggaggagg cccatgagaa gggcaaaatt ctcagcgaac 2340 agaaggcgat gatcaatgct atggattcca agatcagatc cctggaacag aggattgtgg 2400 aactgtctga agccaataaa cttgcagcaa atagcagtct ttttacccaa aggaacatga 2460 aggcccaaga agagatgatt tctgaactca ggcaacagaa attttacctg gagacacagg 2520 ctgggaagtt ggaggcccag aaccgaaaac tggaggagca gctggagaag atcagccacc 2580 aagaccacag tgacaagaat cggctgctgg aactggagac aagattgcgg gaggtcagtc 2640 tagagcacga ggagcagaaa ctggagctca agcgccagct cacagagcta cagctctccc 2700 tgcaggagcg cgagtcacag ttgacagccc tgcaggctgc acgggcggcc ctggagagcc 2760 agcttcgcca ggcgaagaca gagctggaag agaccacagc agaagctgaa gaggagatcc 2820 aggcactcac ggcacataga gatgaaatcc agcgcaaatt tgatgctctt cgtaacagct 2880 gtactgtaat cacagacctg gaggagcagc taaaccagct gaccgaggac aacgctgaac 2940 tcaacaacca aaacttctac ttgtccaaac aactcgatga ggcttctggc gccaacgacg 3000 agattgtaca actgcgaagt gaagtggacc atctccgccg ggagatcacg gaacgagaga 3060 tgcagcttac cagccagaag caaacgatgg aggctctgaa gaccacgtgc accatgctgg 3120 aggaacaggt catggatttg gaggccctaa acgatgagct gctagaaaaa gagcggcagt 3180 gggaggcctg gaggagcgtc ctgggtgatg agaaatccca gtttgagtgt cgggttcgag 3240 agctgcagag aatgctggac accgagaaac agagcagggc gagagccgat cagcggatca 3300 ccgagtctcg ccaggtggtg gagctggcag tgaaggagca caaggctgag attctcgctc 3360 tgcagcaggc tctcaaagag cagaagctga aggccgagag cctctctgac aagctcaatg 3420 acctggagaa gaagcatgct atgcttgaaa tgaatgcccg aagcttacag cagaagctgg 3480 agactgaacg agagctcaaa cagaggcttc tggaagagca agccaaatta cagcagcaga 3540 tggacctgca gaaaaatcac attttccgtc tgactcaagg actgcaagaa gctctagatc 3600 gggctgatct actgaagaca gaaagaagtg acttggagta tcagctggaa aacattcagg 3660 ttctctattc tcatgaaaag gtgaaaatgg aaggcactat ttctcaacaa accaaactca 3720 ttgattttct gcaagccaaa atggaccaac ctgctaaaaa gaaaaagggt ttatttagtc 3780 gacggaaaga ggaccctgct ttacccacac aggttcctct gcagtacaat gagctgaagc 3840 tggccctgga gaaggagaaa gctcgctgtg cagagctaga ggaagccctt cagaagaccc 3900 gcatcgagct ccggtccgcc cgggaggaag ctgcccaccg caaagcaacg gaccacccac 3960 acccatccac gccagccacc gcgaggcagc agatcgccat gtccgccatc gtgcggtcgc 4020 cagagcacca gcccagtgcc atgagcctgc tggccccgcc atccagccgc agaaaggagt 4080 cttcaactcc agaggaattt agtcggcgtc ttaaggaacg catgcaccac aatattcctc 4140 accgattcaa cgtaggactg aacatgcgag ccacaaagtg tgctgtgtgt ctggataccg 4200 tgcactttgg acgccaggca tccaaatgtc tcgaatgtca ggtgatgtgt caccccaagt 4260 gctccacgtg cttgccagcc acctgcggct tgcctgctga atatgccaca cacttcaccg 4320 aggccttctg ccgtgacaaa atgaactccc caggtctcca gaccaaggag cccagcagca 4380 gcttgcacct ggaagggtgg atgaaggtgc ccaggaataa caaacgagga cagcaaggct 4440 gggacaggaa gtacattgtc ctggagggat caaaagtcct catttatgac aatgaagcca 4500 gagaagctgg acagaggccg gtggaagaat ttgagctgtg ccttcccgac ggggatgtat 4560 ctattcatgg tgccgttggt gcttccgaac tcgcaaatac agccaaagca gatgtcccat 4620 acatactgaa gatggaatct cacccgcaca ccacctgctg gcccgggaga accctctact 4680 tgctagctcc cagcttccct gacaaacagc gctgggtcac cgccttagaa tcagttgtcg 4740 caggtgggag agtttctagg gaaaaagcag aagctgatgc taaactgctt ggaaactccc 4800 tgctgaaact ggaaggtgat gaccgtctag acatgaactg cacgctgccc ttcagtgacc 4860 aggtggtgtt ggtgggcacc gaggaagggc tctacgccct gaatgtcttg aaaaactccc 4920 taacccatgt cccaggaatt ggagcagtct tccaaattta tattatcaag gacctggaga 4980 agctactcat gatagcagga gaagagcggg cactgtgtct tgtggacgtg aagaaagtga 5040 aacagtccct ggcccagtcc cacctgcctg cccagcccga catctcaccc aacatttttg 5100 aagctgtcaa gggctgccac ttgtttgggg caggcaagat tgagaacggg ctctgcatct 5160 gtgcagccat gcccagcaaa gtcgtcattc tccgctacaa cgaaaacctc agcaaatact 5220 gcatccggaa agagatagag acctcagagc cctgcagctg tatccacttc accaattaca 5280 gtatcctcat tggaaccaat aaattctacg aaatcgacat gaagcagtac acgctcgagg 5340 aattcctgga taagaatgac cattccttgg cacctgctgt gtttgccgcc tcttccaaca 5400 gcttccctgt ctcaatcgtg caggtgaaca gcgcagggca gcgagaggag tacttgctgt 5460 gtttccacga atttggagtg ttcgtggatt cttacggaag acgtagccgc acagacgatc 5520 tcaagtggag tcgcttacct ttggcctttg cctacagaga accctatctg tttgtgaccc 5580 acttcaactc actcgaagta attgagatcc aggcacgctc ctcagcaggg acccctgccc 5640 gagcgtacct ggacatcccg aacccgcgct acctgggccc tgccatttcc tcaggagcga 5700 tttacttggc gtcctcatac caggataaat taagggtcat ttgctgcaag ggaaacctcg 5760 tgaaggagtc cggcactgaa caccaccggg gcccgtccac ctcccgcagc agccccaaca 5820 agcgaggccc acccacgtac aacgagcaca tcaccaagcg cgtggcctcc agcccagcgc 5880 cgcccgaagg ccccagccac ccgcgagagc caagcacacc ccaccgctac cgcgaggggc 5940 ggaccgagct gcgcagggac aagtctcctg gccgccccct ggagcgagag aagtcccccg 6000 gccggatgct cagcacgcgg agagagcggt cccccgggag gctgtttgaa gacagcagca 6060 ggggccggct gcctgcggga gccgtgagga ccccgctgtc ccaggtgaac aaggtctggg 6120 accagtcttc agtataaatc tcagccagaa aaaccaactc ctcatcttga tctgcaggaa 6180 aacaccaaac acactatgga actctgctga tggggaccca agcgcccacg tgctcagcca 6240 ccctctggct cagcggggcc cagacccacc tcggcacgga cacccctgtc tccaggaggg 6300 gcaggtggct gaggctcttc ggagctgtca gcgcccggtg cctgccctgg gcacctccct 6360 gcagtcatct ctttgcactt tgttactctt tcaaagcatt cacaaacttt tgtacctagc 6420 tctagcctgt accagttagt tcatcaaagg aaaccaaccg ggatgctaac tacaacatgg 6480 ttagaatcct aattagctac tttaagatcc taggattggt tggtttttct tttttttttc 6540 tctttgtttc tttccttttt tttttttttt ttttaagaca acagaattct taatagattt 6600 gaatagcgac gtatttcctg ttgtagtcat ttttagctcg accacatcat caggtctttg 6660 ccaccgaggc atagtgtaga acagtcccgg tcagttggcc aacctcccgc agccaagtag 6720 gttcatcctt gttcctgttc attctcatag atggccctgc tttccccagg gtgacatcgt 6780 agccaaatgt ttactgtttt cattgccttt tatggccttg acgacttccc ctcccaccag 6840 ctgagaatgt atggaggtca tcggggcctc agctcggagg cagtgacttg gggccaaggg 6900 acctcgagac gctttccttc cccacccccc agcgtcatct ccccagcctg ctgttcccgc 6960 tttccatata gctttggcca ggaaagcatg caatagactt gctcggagcc cagcactcct 7020 gggtctcggg gtcggggagg ggacgggggc acccacttcc ttgtctgtga cggcgtgttg 7080 ttccccactc tgggatgggg aagaggcccg tcgggagttc tgcatggcag ttcactgcat 7140 gtgctgcccc cttgggttgc tctgccaatg tattaatacc atcccatagc tcctgccaaa 7200 tcgagaccct ctgacgactt gccgactaac tggccaccac aagctgcagt ctgtagcact 7260 gaacaaacaa aaaacaaaac gctcaagcct tacgaccaga gaaggatttc agcaaaccac 7320 cacctcccac tcagtgtccc ctccaaactt cacacttccc tgcctgcaga ggatgactct 7380 gttcacaccc aatccagcgc ggttctaccc cacgaaactg tgactttcca aatgagcctt 7440 tccctagggc tagacctaag accaggaagt ttgagaaagc agccgcagct caactcttcc 7500 agctccgcca gggttgggaa gtccttaggt gcagtgcggc tcccactggg tctgcggacc 7560 ctcctattag agtacgaaat tcctggcaac tggtacagaa ccaacctaga ggctttgcag 7620 ttggcaagct aactcgcggc cttatttctg cctttaatct cccacaaggc atctgttgct 7680 ttgggtcctc cacgactctt aggcccgcct caacaaccca ggcacctcct aggtaggctc 7740 aaaggtagac ccgtttccac cgcagcaggt gaacatgacc gtgttttcaa ctgtgtccac 7800 agttcagatc cctttccaga ttgcaacctg gcctgcatcc cagctccttc ctgctcgtgt 7860 cttaacctaa gtgctttctt gtttgaaacg cctacaaacc tccatgtggt agctcctttg 7920 gcaaatgtcc tgctgtggcg ttttatgtgt tgcttggagt ctgtggggtc gtactccctc 7980 ccctcccgtc cccagggcag atttgattga atgtttgctg aagttttgtc tcttggtcca 8040 cagtatttgg aaaggtcact gaaaatgggt ctttcagtct tggcatttca tttaggatct 8100 ccatgagaaa tgggcttctt gagccctgaa aatgtatatt gtgtgtctca tctgtgaact 8160 gctttctgct atatagaact agctcaaaag actgtacata tttacaagaa actttatatt 8220 cgtaaaaaaa aaaagaggaa attgaattgg tttctacttt tttattgtaa aaggtgcatt 8280 tttcaacact tacttttggt ttcaatggtg gtagttgtgg acagccatct tcactggagg 8340 gtggggagct ccgtgtgacc accaagatgc cagcaggata taccgtaaca cgaaattgct 8400 gtcaaaagct tattagcatc aatcaagatt ctaggtctcc aaaagtacag gctttttctt 8460 cattaccttt tttattcaga acgaggaaga gaacacaagg aatgattcaa gatccacctt 8520 gagaggaatg aactttgttg ttgaacaatt agtgaaataa agcaatgatc taaact 8576 <210> 6 <211> 1746 <212> DNA <213> Homo sapiens ASF1 anti-silencing function 1 homolog B (S. cerevisiae) (ASF1B) <400> 6 ggaggccggc tatttgaagg cggcgcgcgg actaggtgcg cacttcagtt ctcggagaga 60 agaggcggga gtggacctgg tcagccctac cccactgacc ccaccggacc caggcgcggc 120 ctccgccaca gccacagccc ctgcccctgc tgcggcgcgg cgaggcgagg cgatggccaa 180 ggtgtcggtg ctgaacgtgg cggtcctgga gaacccgagc cctttccaca gccccttccg 240 gttcgagatc agcttcgagt gcagtgaagc cctggcggac gacctggagt ggaagatcat 300 ttatgttggc tcggctgaga gtgaggaatt tgatcagatc ctagactcgg tgctggtggg 360 ccctgtgcca gcagggagac acatgtttgt ctttcaggcc gacgccccca acccatccct 420 catcccagag actgatgccg tgggtgtgac tgtggtcctc atcacctgca cctaccatgg 480 acaggagttc atccgagtgg gctactacgt caacaacgag tacctcaacc ctgagctgcg 540 tgagaacccg cccatgaagc cagatttctc ccagctccag cggaacatct tggcctcgaa 600 cccccgggtg acccgcttcc atatcaactg ggacaacaac atggacaggc tggaggccat 660 agagacccag gacccctccc tgggctgcgg cctcccactc aactgcactc ctatcaaggg 720 cttggggctc cctggctgca tccctggcct cctccctgag aactccatgg actgcatcta 780 actgcaggaa cccagagtgt cccagcacgc cgggaggggc aaccaggcct cccagcgagt 840 cctgcagggc ccatctagag gactttgggg gccatcagct gcaatccagg tctgtcaaac 900 tcagccccta ggaaagaaca ggccttgggt ctcccctagt cctggccaga aggatgatct 960 cgcttttcct ctacaggcct ataagaagca ggtacttcag ttctaaattc tgacttgtgt 1020 tcttttcgtc ttcataaatt ctaactaagg ccactgtgcc actgtgcacc cttgagtacc 1080 attgatccaa agctttccca cagacctccc tggcccacct agaggctttc ttggtcagtg 1140 cctgtcaagg ctccagtcct gctgagccaa aggctttgtc attcctttct cttcctgtac 1200 atctgagcag acccactcca gctttctggt gtcacaggcg ggaatgttag ttagtaggta 1260 gacttagatc ccatttctgt cctgctccca ggaagattct taggtcctct tcaatccagc 1320 agcccctccc agaggtgtga tcagcaggat gctgaggaac catgttgcct ttcctgtcaa 1380 tcacagccac cttcctgtta tctcctaaat ggatctggct tttcctggag gctgccatgg 1440 ttggaagatg gtatcagagg gcctgcctgg gcagtctgtc tccgggccag ggtcagggac 1500 cctctgcctc tggcagcctt aacctgtcct ctgctaggac cagggtgatt tcaagccagg 1560 gaagcaactg ggaccctgaa aactgtccct ccccagcccg ctccccctct ctgtgccctg 1620 gtccccttgc tgccatgtgg atgctgttgt gattgctgtt tgtatattat caaaatgttt 1680 ttatattaaa aatgtttggt ctgaaaatta aaagcacttc atttagaatg aaaaaaaaaa 1740 aaaaaa 1746 <210> 7 <211> 2445 <212> DNA <213> Homo sapiens family with sequence similarity 83, member D (FAM83D) <400> 7 aaagcagcca atgggagagc cgaggcgggg aggtgcggcc aatggcgcgg gcctgtttga 60 ttcaaaggtt gcctataaag cgggactgca cgccggtttt tgtccgaggg ctgtcgagtc 120 cgagcgccgc catggctctg ctgtccgagg gcctggacga ggtgcccgcc gcctgcctgt 180 cgccgtgcgg gccgcccaac ccgaccgagc tgttcagcga gtcacggcgc ctggctctgg 240 aggagctggt ggcgggcggc cccgaagcct tcgcggcctt cctgcgacgc gagcgcctgg 300 ctcgtttcct gaaccccgat gaggtgcacg ccattctgcg cgcggcggag aggccgggag 360 aggagggcgc ggcggcggcg gcggcggccg aggactcgtt cggctcctcg cacgactgct 420 cttcgggcac ctacttcccc gagcagtcgg acctggagcc accgctgttg gagcttggct 480 ggcccgcctt ctaccagggc gcctaccgcg gcgccacgcg tgtcgagacg cacttccagc 540 cccgcggcgc tggcgaaggt ggcccctacg gctgcaagga cgctctgcgc cagcagctcc 600 gctcggcgcg agaggtgatt gcagtggtca tggacgtgtt cacagacatc gacatcttca 660 gagacctgca agaaatatgc aggaaacagg gagttgctgt gtatatcctt ctggaccagg 720 ctctcctctc tcaatttctg gatatgtgca tggatctgaa agttcatcct gaacaggaaa 780 agttaatgac agttcggact atcacaggaa atatctacta tgcaaggtca ggaactaaga 840 ttattgggaa ggttcacgaa aagttcacgt tgattgatgg catccgcgtg gcaacaggct 900 cctacagttt tacatggacg gatggcaaat taaacagcag taacttggta attctgtctg 960 gccaagtggt tgaacacttt gatctggagt tccgaatcct gtatgcccag tccaagccca 1020 tcagccccaa actcctgtct cacttccaga gcagcaacaa gtttgatcac ctcaccaacc 1080 gaaaaccaca gtccaaggag ctcaccctgg gcaacctgct gcggatgcgg ctggctaggc 1140 tgtcaagtac tcccaggaag gcggacctgg acccagagat gcccgcagag ggcaaggcag 1200 agcgcaagcc ccatgactgt gagtcctcta ctgttagtga ggaagactac ttcagcagcc 1260 acagggacga gctccagagc agaaaggcca ttgacgctgc cactcaaaca gagccaggag 1320 aggagatgcc agggctgagt gtgagtgagg tgggaacaca aaccagcatc accacagcat 1380 gtgctggtac ccagactgca gtcatcacca ggatagcaag ctctcaaacc acgatttggt 1440 ccagatcgac cactactcag actgacatgg atgagaacat tctctttcct cgaggaactc 1500 aatctacaga agggtcacca gtctcaaaaa tgtctgtatc gagatcttcc agtttgaagt 1560 cttcctcctc tgtgtcttcc caaggctctg tggcaagctc cactggttct cccgcttcca 1620 tcagaaccac tgacttccac aatcctggct atcccaagta cctgggcacc ccccacctgg 1680 aactgtactt gagtgactca cttagaaact tgaacaaaga gcggcaattc cacttcgctg 1740 gtatcaggtc ccggctcaac cacatgctgg ctatgctgtc aaggagaaca ctctttactg 1800 aaaaccacct tggccttcat tctggcaatt tcagcagagt taatttgctt gctgttagag 1860 atgtagcact ttatccttcc tatcagtaac tgctccgtgt tcagactcct ggtttcttcc 1920 aggcttacag tggacatcat cagcttcctg ctttaaaaaa tatcttatgt ccctaattgc 1980 ctttctttta cctgactttg tcacctttgt tgtctttgaa ttctttaggc tgcatattat 2040 tttacatgct ttgttttgtc atgtatatac caggtattgg ttttatggtt taaacactat 2100 ggatacaggg gtttgttttg cacaatttta atagtcatgc actacataat gatgttttgg 2160 tcaatgacag accacgtata tgttggcagt ctcataagat tataatactg tatttttact 2220 ataccttttc tgtgtttaga tacaaatacc attatgttac agttgcctac agtattcagt 2280 gcagtaacat gatgtacagg tttgtagcct gttttgcatt tttcttaggt tgtatgctct 2340 tctgttttaa aggtttgaat caccagcatt tttgtgatca aaatcctatt tagaaaaaat 2400 aaaactactt tctgtttatc tctttagaaa aaaaaaaaaa aaaaa 2445 <210> 8 <211> 1453 <212> DNA <213> Homo sapiens MAD2 mitotic arrest deficient-like 1 (yeast) (MAD2L1) <400> 8 cgcaaaggac ctgacgacgt gctgcgtcgt tacttttgaa acgcttggcg gggaagtgct 60 gttggagccg ctgtggttgc tgtccgcgga gtggaagcgc gtgcttttgt ttgtgtccct 120 ggccatggcg ctgcagctct cccgggagca gggaatcacc ctgcgcggga gcgccgaaat 180 cgtggccgag ttcttctcat tcggcatcaa cagcatttta tatcagcgtg gcatatatcc 240 atctgaaacc tttactcgag tgcagaaata cggactcacc ttgcttgtaa ctactgatct 300 tgagctcata aaatacctaa ataatgtggt ggaacaactg aaagattggt tatacaagtg 360 ttcagttcag aaactggttg tagttatctc aaatattgaa agtggtgagg tcctggaaag 420 atggcagttt gatattgagt gtgacaagac tgcaaaagat gacagtgcac ccagagaaaa 480 gtctcagaaa gctatccagg atgaaatccg ttcagtgatc agacagatca cagctacggt 540 gacatttctg ccactgttgg aagtttcttg ttcatttgat ctgctgattt atacagacaa 600 agatttggtt gtacctgaaa aatgggaaga gtcgggacca cagtttatta ccaattctga 660 ggaagtccgc cttcgttcat ttactactac aatccacaaa gtaaatagca tggtggccta 720 caaaattcct gtcaatgact gaggatgaca tgaggaaaat aatgtaattg taattttgaa 780 atgtggtttt cctgaaatca agtcatctat agttgatatg ttttatttca ttggttaatt 840 tttacatgga gaaaaccaaa atgatactta ctgaactgtg tgtaattgtt ccttttattt 900 ttttggtacc tatttgactt accatggagt taacatcatg aatttattgc acattgttca 960 aaaggaacca ggaggttttt ttgtcaacat tgtgatgtat attcctttga agatagtaac 1020 tgtagatgga aaaacttgtg ctataaagct agatgctttc ctaaatcaga tgttttggtc 1080 aagtagtttg actcagtata ggtagggaga tatttaagta taaaatacaa caaaggaagt 1140 ctaaatattc agaatctttg ttaaggtcct gaaagtaact cataatctat aaacaatgaa 1200 atattgctgt atagctcctt ttgaccttca tttcatgtat agttttccct attgaatcag 1260 tttccaatta tttgacttta atttatgtaa cttgaaccta tgaagcaatg gatatttgta 1320 ctgtttaatg ttctgtgata cagaactctt aaaaatgttt tttcatgtgt tttataaaat 1380 caagttttaa gtgaaagtga ggaaataaag ttaagtttgt tttaaatttg tcttaaaaaa 1440 aaaaaaaaaa aaa 1453 <210> 9 <211> 3065 <212> DNA <213> Homo sapiens Holliday junction recognition protein (HJURP) <400> 9 ctatttgagt ttgtggcgcg cgaggccctg cagtccgggt tggcgcttgg gtactggctg 60 ggtccgatgc tgggtacgct gcgcgccatg gagggcgagg acgtggaaga cgaccagctg 120 ctgcagaagc tcagggccag tcgccgccgc ttccagaggc gcatgcagcg gctgatagag 180 aagtacaacc agcccttcga ggacaccccg gtggtgcaaa tggccacgct gacctacgag 240 acgccacagg gattgagaat ttggggtgga agactaataa aggaaagaaa cgaaggagag 300 atccaggact cctccatgaa gcccgcggac aggacagatg gctccgtgca agctgcagcc 360 tggggtcctg agcttccctc gcaccgcaca gtcctgggag ccgattcaaa aagcggtgag 420 gtcgatgcca cgtcagacca ggaagagtca gttgcttggg ccttagcacc tgcagtgcct 480 caaagccctt tgaaaaatga attaagaagg aaatacttga cccaagtgga tatactgcta 540 caaggtgcag agtattttga gtgtgcaggt aacagagctg gaagggatgt acgtgtgact 600 ccgctgcctt cactggcctc acctgccgtg cctgcccccg gatactgcag tcgtatctcc 660 agaaagagtc ctggtgaccc agcgaaacca gcttcatctc ccagagaatg ggatcctttg 720 catccttcct ccacagacat ggccttagta cctagaaatg acagcctctc cctacaagag 780 accagtagca gcagcttctt aagcagccag ccctttgaag atgatgacat ttgcaatgtg 840 accatcagtg acctgtacgc agggatgctg cactccatga gccggctgtt gagcacaaag 900 ccatcaagca tcatctccac caaaacgttc atcatgcaaa actggaactc caggaggagg 960 cacagatata agagcaggat gaacaaaaca tattgcaaag gagccagacg ttctcagagg 1020 agctccaagg agaacttcat accctgctct gagcctgtga aagggacagg ggcattaaga 1080 gattgcaaga acgtattaga tgtttcttgc cgtaagacag gtttaaaatt ggaaaaagct 1140 tttcttgaag tcaacagacc ccaaatccat aagttagatc caagttggaa ggagcgcaaa 1200 gtgacaccct cgaagtattc ttccttgatt tacttcgact ccagtgcaac atataatctt 1260 gatgaggaaa atagatttag gacattaaaa tggttaattt ctcctgtaaa aatagtttcc 1320 agaccaacaa tacgacaggg ccatggagag aaccgtcaga gggagattga aatccgattt 1380 gatcagcttc atcgggaata ttgcctgagt cccaggaacc agcctcgccg gatgtgcctc 1440 ccggactcct gggccatgaa catgtacaga gggggtcctg cgagtcctgg tggccttcag 1500 ggcttagaaa cccgcaggct gagtttacct tccagcaaag caaaagcaaa aagtttaagt 1560 gaggcttttg aaaacctagg caaaagatct ctggaagcag gtaggtgcct gcccaagagc 1620 gattcatctt catcacttcc aaagaccaac cccacacaca gcgcaactcg cccgcagcag 1680 acatctgacc ttcacgttca gggaaatagt tctggaatat ttagaaagtc agtgtcaccc 1740 agcaaaactc tttcagtccc agataaagaa gtgccaggcc acggaaggaa tcgttacgat 1800 gaaattaaag aagaatttga caagcttcat caaaagtatt gcctcaaatc tcctgggcag 1860 atgacagtgc ctttatgtat tggagtgtct acagataaag caagtatgga agttcgatat 1920 caaacagaag gcttcttagg aaaattaaat ccagaccctc acttccaggg tttccagaag 1980 ttgccatcat cacccctggg gtgcagaaaa agtctactgg gctcaactgc aattgaggct 2040 ccttcatcta catgtgttgc tcgtgccatc acgagggatg gcacgaggga ccatcagttc 2100 cctgcaaaaa gacccaggct atcagaaccc cagggctccg gacgccaggg caattccctg 2160 ggtgcctcag atggggtgga caacaccgtc agaccgggag accagggcag ctcttcacag 2220 cccaactcag aagagagagg agagaacacg tcttacagga tggaagagaa aagtgatttc 2280 atgctagaaa aattggaaac taaaagtgtg tagctaggtt atttcggagt gttatttatc 2340 ttcccacttg ctctctgttt gtatttttgt tttgtttttg attcttgaga ctgtgaggac 2400 ttggttgact tctctgccct taaagtaaat attagtgaaa ttggttccat cagagataac 2460 ctcgagttct tggtgtagaa attatgtgaa taaagttgct caattagaat ttttagggtt 2520 ctctttgata ggcctgtttt tctgatgtgt gtgttttttt tggggggggg ttatttgttt 2580 gtttgtttgt ttgtttgttt gtttttgaga cagtctctct ctatcgccca ggctggagtg 2640 cggtggcaca atcttggctc actgcaactt ccgcctcccg ggttcaagcg attcttctgc 2700 ctcagcctcc cgagtagctg ggattacagg cgcgcgccac cacgcctggc taatttttgt 2760 agttttagta gagacggggt ttcaccatat tgaccaggct ggtctcgagc tcctggcctc 2820 gtgatccatc tgcctcggcc tcccaaagtg ctgggattat aggcgtgagc cactgctccc 2880 agccgtgtgt tcttttttaa atttagatat gtccagagaa tcctctctcc tgtttcccat 2940 ttcattcgag aatattgttt gcttgtgaga cgtaagttcg agccctgcat gcaatgaccc 3000 ttgaaggaaa ataaacagtc ctggtggtcc cagacgctcc tgcagccaca aaaaaaaaaa 3060 aaaaa 3065 <210> 10 <211> 6286 <212> DNA <213> Homo sapiens nucleoporin 205kDa (NUP205) <400> 10 ggcagaaggg ctctgttagt gcgcctctaa gatggcgacg cctttggcgg taaattcggc 60 tgctagtcta tggggtcctt acaaagacat ttggcataaa gtgggaaatg ctctttggag 120 aagacaacct gaagctgttc accttcttga taagattttg aagaaacaca aacctgactt 180 catctcattg ttcaaaaatc cgccaaaaaa tgttcaacag catgagaagg ttcagaaagc 240 cagtacagag ggagtcgcca ttcagggtca acagggaact cgacttcttc ctgaacagct 300 cattaaagaa gcctttattc tcagtgacct ttttgatatt ggagaattgg cagctgttga 360 gcttcttctt gctggagagc atcaacagcc acattttcct ggccttacca gaggattagt 420 agctgttctt ctgtactggg atggaaagcg atgcattgcg aattccttga aagccttgat 480 acagtctaga cggggaaaga catggaccct agaactcagt ccagagctgg cttccatgac 540 aacacgcttt acagatgagc tgatggagca aggattgact tataaagttc ttacgctggt 600 gtcacagatt gatgtgaata atgagtttga gaaactacag cgagagagag gtttgggcag 660 tgaaaaacat cgcaaagagg tttctgatct cattaaggag tgcaggcagt ctcttgcaga 720 aagccttttt gcctgggctt gccagtcacc tttaggcaaa gaagacactc tcctcctcat 780 tggacatttg gaaagagtga cagttgaggc taatggctca ctggatgcag tgaatctggc 840 tcttcttatg gcgcttctat actgttttga tatcagtttt atagagcaaa gcacagagga 900 acgagatgat atgattcatc aacttccact gttgacagaa aaacagtaca ttgcaacaat 960 tcactctcgt cttcaggact cacagctttg gaaactgcct gggctccaag ccactgttag 1020 acttgcctgg gcgctggcat tgaggggaat atcccagcta cctgatgtga cagctctggc 1080 agaattcaca gaggcagatg aagcaatggc agaactcgca attgctgaca acgttttcct 1140 gttcctcatg gaatctgtag tggtatcaga atacttttat caggaagaat tttatattcg 1200 cagagtccat aatctcatca cagatttcct tgcacttatg ccaatgaagg tgaaacagct 1260 gaggaatcgg gcagatgaag atgctcgaat gattcacatg agtatgcaga tgggtaatga 1320 accccccatt tcacttagaa gggacctgga acacttaatg cttttgattg gcgagctata 1380 taaaaagaac ccttttcatc tggagcttgc tctagaatat tggtgtccca cagagcctct 1440 tcagactccg actatcatgg gctcttatct aggggtggct catcagcggc cccctcaacg 1500 ccaggttgtc ttgtcaaagt ttgttaggca aatgggtgac ctgttgcctc caactattta 1560 tattccttat ttgaagatgc tccagggatt ggccaatggg cctcagtgtg cccactactg 1620 tttcagcctg ctcaaagtca atggtagtag tcatgttgaa aatattcagg gagcaggtgg 1680 cagtcctgtt tcctgggaac atttctttca ctccttgatg ctttaccacg aacaccttcg 1740 gaaggatctt ccaagtgcag atagtgtcca gtaccgtcac cttccttccc gtggcatcac 1800 ccagaaggag caagatggat tgattgcttt tttgcagctc acgtctacca tcattacttg 1860 gagtgaaaat gctcgcttgg cactctgtga acaccctcag tggacccctg ttgtggtgat 1920 tctgggactc ctccaatgca gtattccccc tgtcctaaaa gctgagctac tgaagacact 1980 cgcagctttt ggaaaatctc ctgaaattgc tgcttccctc tggcagtcat tggaatacac 2040 tcagatactg cagaccgtga ggattccaag ccaaaggcaa gctattggta ttgaggttga 2100 actaaatgaa atagaatccc ggtgtgaaga atacccattg actcgggcct tttgccagct 2160 tattagtact ctggtggaga gctcatttcc ttctaatttg ggtgctggac tgcggccccc 2220 tggctttgac ccttatttgc agttccttag agactctgtg tttctacgat tccgtacaag 2280 agcttaccgg agagcagctg aaaagtggga agttgctgag gtggttttgg aggtgtttta 2340 taaattgctc agagattatg agcctcagct tgaagatttt gtagaccagt ttgtggaact 2400 acaaggagaa gaaatcatag cctataagcc acctggattt agtctgatgt atcatctgct 2460 gaatgagtca ccaatgttgg agcttgctct cagtttactg gaagaaggag ttaagcagct 2520 tgacacctat gccccctttc ctgggaaaaa acacctggag aaagcagtac agcattgcct 2580 tgcacttctc aatcttactc tgcaaaagga aaatcttttt atggaccttc taagagagag 2640 tcaactggct ctaatagtct gtcctttaga acagcttttg cagggaatta atcccagaac 2700 taagaaggca gataatgtgg taaacattgc cagataccta tatcatggca atactaatcc 2760 agaattggct tttgaaagtg ccaagatcct ctgttgtatc tcttgcaact ctaatattca 2820 gataaagttg gttggagatt tcacacatga ccagagtata agtcagaaac taatggctgg 2880 atttgtggag tgtttggatt gtgaagatgc agaagaattt gtacgtctgg aagagggatc 2940 agaacttgaa aagaaattag ttgcaattcg tcatgaaaca agaatccaca tcttgaatct 3000 tctcattacc tctctggaat gcaatccacc caatcttgct ctctacctgt tgggctttga 3060 attgaaaaaa cctgtcagta ctacaaacct acaagatcca ggagtgttag gttgccctcg 3120 gacatgcctt cacgccattc taaacatctt ggagaaagga acggaaggga gaacaggccc 3180 agtggcggtg cgagaatctc ctcagctggc tgagctatgt taccaggtca tatatcagtt 3240 atgtgcatgc tctgatacat ctggtcctac tatgaggtac ttgagaacca gccaggattt 3300 cttattttcc cagttgcagt atctaccatt ttctaacaaa gaatatgaaa tatctatgct 3360 gaaccagatg tcatggctta tgaaaactgc ctcaatagag ctaagggtaa cctctctgaa 3420 tcgtcagcgg tcacataccc agaggctcct acacctctta ctggatgaca tgccagtgaa 3480 accatactca gatggtgaag gaggaataga agatgaaaac aggtctgttt ctgggttcct 3540 tcactttgac actgctacaa aagtacgtcg aaaaattcta aatattcttg actcgattga 3600 cttcagtcag gagatccctg agcctttgca gttggatttt tttgatcggg cccagattga 3660 acaagttatt gctaactgtg aacacaagaa tttacgggga cagacagtct gcaatgtcaa 3720 gcttcttcat agggttcttg tagctgaagt aaatgccctt cagggtatgg cagccatagg 3780 acagagacct ctactaatgg aggaaatcag cactgtactt cagtatgtgg taggaagaaa 3840 taaattgctg cagtgtcttc atgcaaaacg tcatgctctg gagtcgtgga ggcaactagt 3900 agaaattata ctgacagctt gtccccagga cctcattcag gcagaggatc gacaactgat 3960 tattcgtgat attttacaag atgtgcatga taagatactg gatgatgaag ctgcgcaaga 4020 gttaatgcct gtggtcgccg gggcagtgtt cacactgact gctcacctaa gccaggccgt 4080 cctcactgaa cagaagcaaa catcagtctt gggaccagca gaggcccatt acgcttttat 4140 gcttgatagt tgcttcacct cacctcctcc tgaagagaac ccattagtgg gttttgcttc 4200 tattggagat tcttcacttt acatcatatt gaagaaactg ttagacttca ttttgaagac 4260 aggtggtgga ttccaacgag tgaggactca cttgtatggc tctctgcttt attacttaca 4320 gattgcccag agacctgatg aaccagacac cttagaagca gccaagaaaa ccatgtggga 4380 aaggctgaca gcccctgaag atgtatttag caaattacag cgagaaaaca tagccattat 4440 tgaaagttat ggcgccgccc tcatggaagt ggtctgtcga gatgcttgtg atggtcatga 4500 gattggaagg atgctggccc tggctctact tgatagaatt gtctccgtgg ataaacagca 4560 gcagtggctt ttgtatcttt ctaacagtgg ctacttgaag gtcctcgtag acagcttggt 4620 agaagatgac cgtactttgc agagcttact caccccacag cctccccttt taaaagcact 4680 ttatacttat gaatctaaaa tggcatttct cacaagagtg gcaaagatac agcagggtgc 4740 attagagctg ctaagatcag gggtgattgt gagactagct caatgccaag tctatgacat 4800 gcgcccagaa acggacccgc agagcatgtt tggcatgaga gaccctccaa tgttcatccc 4860 taccccagtg gatcgctacc gccagattct cctcccagct ctccagctgt gccaggtcat 4920 cctcacatct agtatggccc agcacttgca ggcagcaggg caggtattgc agtttcttat 4980 ttcacattct gataccatac aagcaattct gcgctgtcag gatgttagtg ctgggtcttt 5040 gcaggaattg gctctgctga caggaattat aagtaaagca gcacttcctg gaatattaag 5100 tgaacttgac gttgatgtaa atgaagggtc tctaatggag ctacagggac atattggaag 5160 attccagcgc cagtgcttag gactactaag tcgctttggt ggctctgaca gactgcgtca 5220 gtttaaattt caagacgata atgtggaggg agataaagta agcaagaaag atgagattga 5280 actggctatg cagcagattt gtgccaatgt aatggaatat tgccagtcac tcatgttaca 5340 gagttcccct accttccagc atgctgtgtg tctcttcact cctagccttt cagaaacagt 5400 taatagagat ggaccgcggc aagataccca agctccagtg gttccatact ggcgcctgcc 5460 tggtttaggc attatcatct acctgctgaa acagagtgct aatgatttct tcagctatta 5520 tgacagtcat cgacagagtg tcagcaagct acaaaatgta gagcagcttc ccccagatga 5580 gataaaagag ttgtgtcagt ctgtgatgcc tgctggtgtt gataaaatct ccactgctca 5640 gaaatatgtt ctagcaagac ggcgcttggt gaaggtgatc aacaatcgag ctaaactgct 5700 ttccctttgt tcttttatca tagagacctg cctatttatt ctttggcgcc atctggagta 5760 ctacttgtta cattgcatgc ccacggattc tcaagattcc ttatttgcct cgagaacctt 5820 gtttaaaagc agaagactgc aagattcctt cgcctcagaa accaatctag attttagaag 5880 tgggctggct atagtgagcc aacatgattt agaccagctt caggctgatg caatcaacgc 5940 ttttggagaa tcactacaaa agaaacttct ggacattgaa ggattatatt caaaagttcg 6000 atctcgatat agtttcatac aggctcttgt cagacgtatc cgtggcctct tgaggatatc 6060 aaggaactga gagcccgtgc ttatgctctt ctatgagaga gatgaattgg ggagaattgt 6120 ctccatttta tagattagtt tctttctaaa ttatgaccaa aaatattttg ctatttcttt 6180 ctttgtatat ggacatcttt tctgtaaact tcttccccta gttccatcct cactagtaaa 6240 aaataaatac tttttaaaaa aacaaaaaaa aaaaaaaaaa aaaaaa 6286 <210> 11 <211> 2408 <212> DNA <213> Homo sapiens thyroid hormone receptor interactor 13 (TRIP13) <400> 11 cgggtcagga ggtggtgcgc ctcgcgcggc agattcgaag ctagggcggg gcccgcgggc 60 tgaggcagcg gctgtggcgg cgacgctggg cgtgaggtgg cggcggccgc gccctggttg 120 ggtccccact gctctcgggg gcgccatgga cgaggccgtg ggcgacctga agcaggcgct 180 tccctgtgtg gccgagtcgc caacggtcca cgtggaggtg catcagcgcg gcagcagcac 240 tgcaaagaaa gaagacataa acctgagtgt tagaaagcta ctcaacagac ataatattgt 300 gtttggtgat tacacatgga ctgagtttga tgaacctttt ttgaccagaa atgtgcagtc 360 tgtgtctatt attgacacag aattaaaggt taaagactca cagcccatcg atttgagtgc 420 atgcactgtt gcacttcaca ttttccagct gaatgaagat ggccccagca gtgaaaatct 480 ggaggaagag acagaaaaca taattgcagc aaatcactgg gttctacctg cagctgaatt 540 ccatgggctt tgggacagct tggtatacga tgtggaagtc aaatcccatc tcctcgatta 600 tgtgatgaca actttactgt tttcagacaa gaacgtcaac agcaacctca tcacctggaa 660 ccgggtggtg ctgctccacg gtcctcctgg cactggaaaa acatccctgt gtaaagcgtt 720 agcccagaaa ttgacaatta gactttcaag caggtaccga tatggccaat taattgaaat 780 aaacagccac agcctctttt ctaagtggtt ttcggaaagt ggcaagctgg taaccaagat 840 gtttcagaag attcaggatt tgattgatga taaagacgcc ctggtgttcg tgctgattga 900 tgaggtggag agtctcacag ccgcccgaaa tgcctgcagg gcgggcaccg agccatcaga 960 tgccatccgc gtggtcaatg ctgtcttgac ccaaattgat cagattaaaa ggcattccaa 1020 tgttgtgatt ctgaccactt ctaacatcac cgagaagatc gacgtggcct tcgtggacag 1080 ggctgacatc aagcagtaca ttgggccacc ctctgcagca gccatcttca aaatctacct 1140 ctcttgtttg gaagaactga tgaagtgtca gatcatatac cctcgccagc agctgctgac 1200 cctccgagag ctagagatga ttggcttcat tgaaaacaac gtgtcaaaat tgagccttct 1260 tttgaatgac atttcaagga agagcgaggg cctcagcggc cgggtcctga gaaaactccc 1320 ctttctggct catgcgctgt atgtccaggc ccccaccgtc accatagagg ggttcctcca 1380 ggccctgtct ctggcagtgg acaagcagtt tgaagagaga aagaagcttg cagcttacat 1440 ctgatcctgg gcttccccat ctggtgcttt tcccatggag aacacacaac cagtaagtga 1500 ggttgcccca cacagccgtc tcccagggaa tcccttctgc aaaccaaacg ttacttagac 1560 tgcaagctag aaagccacca aggccaggct ttgttaaaag aagtgtattc tatttatgtt 1620 gttttaaaat gcatactgag agacaaacat cttgtcattt tcactgtttg taaaagataa 1680 ttcagattgt ttgtctcctt gtgaagaacc atcgaaacct gtttgttccc agcccacccc 1740 cagtggatgg gatgcataat gccagcaagt tttgtttaac agcaaaaaag gaagattaat 1800 gcaggtgtta tagaagccag aagagaaact gtgtcaccct aaagaagcat ataatcatag 1860 cattaaaaat gcacacatta ctccaggtgg aaggtggcaa ttgctttctg atatcagctc 1920 gtttgattta gtgcaaaaat gttttcaaga ctatttaatg gatgtaaaaa agcctatttc 1980 tacattatac caactgagaa aaaaatggtc ggtaaagtgt tctttcataa taaataatca 2040 gacatggtcc catttgcagg aaaagtgcag actctgagtg ttccagggaa acacatgctg 2100 gacatccctt gtaacccggt atgggcgccc ctgcattgct gggatgtttc tgcccacggt 2160 tttgtttgtg caataacgtt atcacatttc taatgaggat tcacattaat ataatataaa 2220 ataaataggt cagttactgg tctctttctc cgaatgttat gttttgcttt tatctcacag 2280 taaaataaat ataattaatg gtttgcatgt gaaattcact tttgaaagaa catgttacct 2340 taccttttgt tttagaagtt ttcaagtatt aaaatatttt ttagaatttt aaaaaaaaaa 2400 aaaaaaaa 2408 <210> 12 <211> 2723 <212> DNA <213> Homo sapiens enhancer of zeste homolog 2 (Drosophila) (EZH2) <400> 12 ggcggcgctt gattgggctg ggggggccaa ataaaagcga tggcgattgg gctgccgcgt 60 ttggcgctcg gtccggtcgc gtccgacacc cggtgggact cagaaggcag tggagccccg 120 gcggcggcgg cggcggcgcg cgggggcgac gcgcgggaac aacgcgagtc ggcgcgcggg 180 acgaagaata atcatgggcc agactgggaa gaaatctgag aagggaccag tttgttggcg 240 gaagcgtgta aaatcagagt acatgcgact gagacagctc aagaggttca gacgagctga 300 tgaagtaaag agtatgttta gttccaatcg tcagaaaatt ttggaaagaa cggaaatctt 360 aaaccaagaa tggaaacagc gaaggataca gcctgtgcac atcctgactt ctgtgagctc 420 attgcgcggg actagggagt gttcggtgac cagtgacttg gattttccaa cacaagtcat 480 cccattaaag actctgaatg cagttgcttc agtacccata atgtattctt ggtctcccct 540 acagcagaat tttatggtgg aagatgaaac tgttttacat aacattcctt atatgggaga 600 tgaagtttta gatcaggatg gtactttcat tgaagaacta ataaaaaatt atgatgggaa 660 agtacacggg gatagagaat gtgggtttat aaatgatgaa atttttgtgg agttggtgaa 720 tgcccttggt caatataatg atgatgacga tgatgatgat ggagacgatc ctgaagaaag 780 agaagaaaag cagaaagatc tggaggatca ccgagatgat aaagaaagcc gcccacctcg 840 gaaatttcct tctgataaaa tttttgaagc catttcctca atgtttccag ataagggcac 900 agcagaagaa ctaaaggaaa aatataaaga actcaccgaa cagcagctcc caggcgcact 960 tcctcctgaa tgtaccccca acatagatgg accaaatgct aaatctgttc agagagagca 1020 aagcttacac tcctttcata cgcttttctg taggcgatgt tttaaatatg actgcttcct 1080 acatcgtaag tgcaattatt cttttcatgc aacacccaac acttataagc ggaagaacac 1140 agaaacagct ctagacaaca aaccttgtgg accacagtgt taccagcatt tggagggagc 1200 aaaggagttt gctgctgctc tcaccgctga gcggataaag accccaccaa aacgtccagg 1260 aggccgcaga agaggacggc ttcccaataa cagtagcagg cccagcaccc ccaccattaa 1320 tgtgctggaa tcaaaggata cagacagtga tagggaagca gggactgaaa cggggggaga 1380 gaacaatgat aaagaagaag aagagaagaa agatgaaact tcgagctcct ctgaagcaaa 1440 ttctcggtgt caaacaccaa taaagatgaa gccaaatatt gaacctcctg agaatgtgga 1500 gtggagtggt gctgaagcct caatgtttag agtcctcatt ggcacttact atgacaattt 1560 ctgtgccatt gctaggttaa ttgggaccaa aacatgtaga caggtgtatg agtttagagt 1620 caaagaatct agcatcatag ctccagctcc cgctgaggat gtggatactc ctccaaggaa 1680 aaagaagagg aaacaccggt tgtgggctgc acactgcaga aagatacagc tgaaaaagga 1740 cggctcctct aaccatgttt acaactatca accctgtgat catccacggc agccttgtga 1800 cagttcgtgc ccttgtgtga tagcacaaaa tttttgtgaa aagttttgtc aatgtagttc 1860 agagtgtcaa aaccgctttc cgggatgccg ctgcaaagca cagtgcaaca ccaagcagtg 1920 cccgtgctac ctggctgtcc gagagtgtga ccctgacctc tgtcttactt gtggagccgc 1980 tgaccattgg gacagtaaaa atgtgtcctg caagaactgc agtattcagc ggggctccaa 2040 aaagcatcta ttgctggcac catctgacgt ggcaggctgg gggattttta tcaaagatcc 2100 tgtgcagaaa aatgaattca tctcagaata ctgtggagag attatttctc aagatgaagc 2160 tgacagaaga gggaaagtgt atgataaata catgtgcagc tttctgttca acttgaacaa 2220 tgattttgtg gtggatgcaa cccgcaaggg taacaaaatt cgttttgcaa atcattcggt 2280 aaatccaaac tgctatgcaa aagttatgat ggttaacggt gatcacagga taggtatttt 2340 tgccaagaga gccatccaga ctggcgaaga gctgtttttt gattacagat acagccaggc 2400 tgatgccctg aagtatgtcg gcatcgaaag agaaatggaa atcccttgac atctgctacc 2460 tcctcccccc tcctctgaaa cagctgcctt agcttcagga acctcgagta ctgtgggcaa 2520 tttagaaaaa gaacatgcag tttgaaattc tgaatttgca aagtactgta agaataattt 2580 atagtaatga gtttaaaaat caacttttta ttgccttctc accagctgca aagtgttttg 2640 taccagtgaa tttttgcaat aatgcagtat ggtacatttt tcaactttga ataaagaata 2700 cttgaacttg tccttgttga atc 2723 <210> 13 <211> 5753 <212> DNA <213> Homo sapiens topoisomerase (DNA) II alpha 170kDa (TOP2A) <400> 13 gattggctgg tctgcttcgg gcgggctaaa ggaaggttca agtggagctc tcctaaccga 60 cgcgcgtctg tggagaagcg gcttggtcgg gggtggtctc gtggggtcct gcctgtttag 120 tcgctttcag ggttcttgag ccccttcacg accgtcacca tggaagtgtc accattgcag 180 cctgtaaatg aaaatatgca agtcaacaaa ataaagaaaa atgaagatgc taagaaaaga 240 ctgtctgttg aaagaatcta tcaaaagaaa acacaattgg aacatatttt gctccgccca 300 gacacctaca ttggttctgt ggaattagtg acccagcaaa tgtgggttta cgatgaagat 360 gttggcatta actataggga agtcactttt gttcctggtt tgtacaaaat ctttgatgag 420 attctagtta atgctgcgga caacaaacaa agggacccaa aaatgtcttg tattagagtc 480 acaattgatc cggaaaacaa tttaattagt atatggaata atggaaaagg tattcctgtt 540 gttgaacaca aagttgaaaa gatgtatgtc ccagctctca tatttggaca gctcctaact 600 tctagtaact atgatgatga tgaaaagaaa gtgacaggtg gtcgaaatgg ctatggagcc 660 aaattgtgta acatattcag taccaaattt actgtggaaa cagccagtag agaatacaag 720 aaaatgttca aacagacatg gatggataat atgggaagag ctggtgagat ggaactcaag 780 cccttcaatg gagaagatta tacatgtatc acctttcagc ctgatttgtc taagtttaaa 840 atgcaaagcc tggacaaaga tattgttgca ctaatggtca gaagagcata tgatattgct 900 ggatccacca aagatgtcaa agtctttctt aatggaaata aactgccagt aaaaggattt 960 cgtagttatg tggacatgta tttgaaggac aagttggatg aaactggtaa ctccttgaaa 1020 gtaatacatg aacaagtaaa ccacaggtgg gaagtgtgtt taactatgag tgaaaaaggc 1080 tttcagcaaa ttagctttgt caacagcatt gctacatcca agggtggcag acatgttgat 1140 tatgtagctg atcagattgt gactaaactt gttgatgttg tgaagaagaa gaacaagggt 1200 ggtgttgcag taaaagcaca tcaggtgaaa aatcacatgt ggatttttgt aaatgcctta 1260 attgaaaacc caacctttga ctctcagaca aaagaaaaca tgactttaca acccaagagc 1320 tttggatcaa catgccaatt gagtgaaaaa tttatcaaag ctgccattgg ctgtggtatt 1380 gtagaaagca tactaaactg ggtgaagttt aaggcccaag tccagttaaa caagaagtgt 1440 tcagctgtaa aacataatag aatcaaggga attcccaaac tcgatgatgc caatgatgca 1500 gggggccgaa actccactga gtgtacgctt atcctgactg agggagattc agccaaaact 1560 ttggctgttt caggccttgg tgtggttggg agagacaaat atggggtttt ccctcttaga 1620 ggaaaaatac tcaatgttcg agaagcttct cataagcaga tcatggaaaa tgctgagatt 1680 aacaatatca tcaagattgt gggtcttcag tacaagaaaa actatgaaga tgaagattca 1740 ttgaagacgc ttcgttatgg gaagataatg attatgacag atcaggacca agatggttcc 1800 cacatcaaag gcttgctgat taattttatc catcacaact ggccctctct tctgcgacat 1860 cgttttctgg aggaatttat cactcccatt gtaaaggtat ctaaaaacaa gcaagaaatg 1920 gcattttaca gccttcctga atttgaagag tggaagagtt ctactccaaa tcataaaaaa 1980 tggaaagtca aatattacaa aggtttgggc accagcacat caaaggaagc taaagaatac 2040 tttgcagata tgaaaagaca tcgtatccag ttcaaatatt ctggtcctga agatgatgct 2100 gctatcagcc tggcctttag caaaaaacag atagatgatc gaaaggaatg gttaactaat 2160 ttcatggagg atagaagaca acgaaagtta cttgggcttc ctgaggatta cttgtatgga 2220 caaactacca catatctgac atataatgac ttcatcaaca aggaacttat cttgttctca 2280 aattctgata acgagagatc tatcccttct atggtggatg gtttgaaacc aggtcagaga 2340 aaggttttgt ttacttgctt caaacggaat gacaagcgag aagtaaaggt tgcccaatta 2400 gctggatcag tggctgaaat gtcttcttat catcatggtg agatgtcact aatgatgacc 2460 attatcaatt tggctcagaa ttttgtgggt agcaataatc taaacctctt gcagcccatt 2520 ggtcagtttg gtaccaggct acatggtggc aaggattctg ctagtccacg atacatcttt 2580 acaatgctca gctctttggc tcgattgtta tttccaccaa aagatgatca cacgttgaag 2640 tttttatatg atgacaacca gcgtgttgag cctgaatggt acattcctat tattcccatg 2700 gtgctgataa atggtgctga aggaatcggt actgggtggt cctgcaaaat ccccaacttt 2760 gatgtgcgtg aaattgtaaa taacatcagg cgtttgatgg atggagaaga acctttgcca 2820 atgcttccaa gttacaagaa cttcaagggt actattgaag aactggctcc aaatcaatat 2880 gtgattagtg gtgaagtagc tattcttaat tctacaacca ttgaaatctc agagcttccc 2940 gtcagaacat ggacccagac atacaaagaa caagttctag aacccatgtt gaatggcacc 3000 gagaagacac ctcctctcat aacagactat agggaatacc atacagatac cactgtgaaa 3060 tttgttgtga agatgactga agaaaaactg gcagaggcag agagagttgg actacacaaa 3120 gtcttcaaac tccaaactag tctcacatgc aactctatgg tgctttttga ccacgtaggc 3180 tgtttaaaga aatatgacac ggtgttggat attctaagag acttttttga actcagactt 3240 aaatattatg gattaagaaa agaatggctc ctaggaatgc ttggtgctga atctgctaaa 3300 ctgaataatc aggctcgctt tatcttagag aaaatagatg gcaaaataat cattgaaaat 3360 aagcctaaga aagaattaat taaagttctg attcagaggg gatatgattc ggatcctgtg 3420 aaggcctgga aagaagccca gcaaaaggtt ccagatgaag aagaaaatga agagagtgac 3480 aacgaaaagg aaactgaaaa gagtgactcc gtaacagatt ctggaccaac cttcaactat 3540 cttcttgata tgcccctttg gtatttaacc aaggaaaaga aagatgaact ctgcaggcta 3600 agaaatgaaa aagaacaaga gctggacaca ttaaaaagaa agagtccatc agatttgtgg 3660 aaagaagact tggctacatt tattgaagaa ttggaggctg ttgaagccaa ggaaaaacaa 3720 gatgaacaag tcggacttcc tgggaaaggg gggaaggcca aggggaaaaa aacacaaatg 3780 gctgaagttt tgccttctcc gcgtggtcaa agagtcattc cacgaataac catagaaatg 3840 aaagcagagg cagaaaagaa aaataaaaag aaaattaaga atgaaaatac tgaaggaagc 3900 cctcaagaag atggtgtgga actagaaggc ctaaaacaaa gattagaaaa gaaacagaaa 3960 agagaaccag gtacaaagac aaagaaacaa actacattgg catttaagcc aatcaaaaaa 4020 ggaaagaaga gaaatccctg gtctgattca gaatcagata ggagcagtga cgaaagtaat 4080 tttgatgtcc ctccacgaga aacagagcca cggagagcag caacaaaaac aaaattcaca 4140 atggatttgg attcagatga agatttctca gattttgatg aaaaaactga tgatgaagat 4200 tttgtcccat cagatgctag tccacctaag accaaaactt ccccaaaact tagtaacaaa 4260 gaactgaaac cacagaaaag tgtcgtgtca gaccttgaag ctgatgatgt taagggcagt 4320 gtaccactgt cttcaagccc tcctgctaca catttcccag atgaaactga aattacaaac 4380 ccagttccta aaaagaatgt gacagtgaag aagacagcag caaaaagtca gtcttccacc 4440 tccactaccg gtgccaaaaa aagggctgcc ccaaaaggaa ctaaaaggga tccagctttg 4500 aattctggtg tctctcaaaa gcctgatcct gccaaaacca agaatcgccg caaaaggaag 4560 ccatccactt ctgatgattc tgactctaat tttgagaaaa ttgtttcgaa agcagtcaca 4620 agcaagaaat ccaaggggga gagtgatgac ttccatatgg actttgactc agctgtggct 4680 cctcgggcaa aatctgtacg ggcaaagaaa cctataaagt acctggaaga gtcagatgaa 4740 gatgatctgt tttaaaatgt gaggcgatta ttttaagtaa ttatcttacc aagcccaaga 4800 ctggttttaa agttacctga agctcttaac ttcctcccct ctgaatttag tttggggaag 4860 gtgtttttag tacaagacat caaagtgaag taaagcccaa gtgttcttta gctttttata 4920 atactgtcta aatagtgacc atctcatggg cattgttttc ttctctgctt tgtctgtgtt 4980 ttgagtctgc tttcttttgt ctttaaaacc tgatttttaa gttcttctga actgtagaaa 5040 tagctatctg atcacttcag cgtaaagcag tgtgtttatt aaccatccac taagctaaaa 5100 ctagagcagt ttgatttaaa agtgtcactc ttcctccttt tctactttca gtagatatga 5160 gatagagcat aattatctgt tttatcttag ttttatacat aatttaccat cagatagaac 5220 tttatggttc tagtacagat actctactac actcagcctc ttatgtgcca agtttttctt 5280 taagcaatga gaaattgctc atgttcttca tcttctcaaa tcatcagagg ccgaagaaaa 5340 acactttggc tgtgtctata acttgacaca gtcaatagaa tgaagaaaat tagagtagtt 5400 atgtgattat ttcagctctt gacctgtccc ctctggctgc ctctgagtct gaatctccca 5460 aagagagaaa ccaatttcta agaggactgg attgcagaag actcggggac aacatttgat 5520 ccaagatctt aaatgttata ttgataacca tgctcagcaa tgagctatta gattcatttt 5580 gggaaatctc cataatttca atttgtaaac tttgttaaga cctgtctaca ttgttatatg 5640 tgtgtgactt gagtaatgtt atcaacgttt ttgtaaatat ttactatgtt tttctattag 5700 ctaaattcca acaattttgt actttaataa aatgttctaa acattgcaac cca 5753 <210> 14 <211> 1490 <212> DNA <213> Homo sapiens ubiquitin-conjugating enzyme E2C (UBE2C) <400> 14 aaacgcgggc gggcgggccc gcagtcctgc agttgcagtc gtgttctccg agttcctgtc 60 tctctgccaa cgccgcccgg atggcttccc aaaaccgcga cccagccgcc actagcgtcg 120 ccgccgcccg taaaggagct gagccgagcg ggggcgccgc ccggggtccg gtgggcaaaa 180 ggtgagtgat gcggcctacc actcgccggg cctgccatgc cctaggcatt ggtacccaga 240 gcaaagattt ctaggaccac cccccgccgc cacctcctgg agcgggagat ctgcgggtgc 300 aggagaacac accaggagct cggggcctgg cattcccctg ggcatgggtg tcgagggcgg 360 agacttccgg gactcccacc tccttgcgcg ggtgagattc gagagatggg ggacaggcca 420 ggagctcaga ccgctctttg agactctccc gaaggagaat gggagggtag gggcgctgcc 480 agactccttc cctggtgggc ctagatgaag acgctcaagg accctcgtga cttggccgag 540 acaggggaag ggagaagttg agtcgggcaa ggaagagatg ctaaagcctg gggaattaag 600 aacatgccag aatcatcccg agggagtctg gaattaggga gggtgaggac tcgctaggat 660 cgtcctgtgg atctggtgag tataccctga gctgagcctg accttggtga tgtggggagc 720 ctccatgacg gctccccctg agattcaggt gggagaagat gcaccgtctg gaggcctggc 780 ccatccagac tcccaggtaa ccccgaatac tcttttttca ggctacagca ggagctgatg 840 accctcatga tgtctggcga taaagggatt tctgccttcc ctgaatcaga caaccttttc 900 aaatgggtag ggaccatcca tggagcagct ggaacagtat atgaagacct gaggtataag 960 ctctcgctag agttccccag tggctaccct tacaatgcgc ccacagtgaa gttcctcacg 1020 ccctgctatc accccaacgt ggacacccag ggtaacatat gcctggacat cctgaaggaa 1080 aagtggtctg ccctgtatga tgtcaggacc attctgctct ccatccagag ccttctagga 1140 gaacccaaca ttgatagtcc cttgaacaca catgctgccg agctctggaa aaaccccaca 1200 gcttttaaga agtacctgca agaaacctac tcaaagcagg tcaccagcca ggagccctga 1260 cccaggctgc ccagcctgtc cttgtgtcgt ctttttaatt tttccttaga tggtctgtcc 1320 tttttgtgat ttctgtatag gactctttat cttgagctgt ggtatttttg ttttgttttt 1380 gtcttttaaa ttaagcctcg gttgagccct tgtatattaa ataaatgcat ttttgtcctt 1440 ttttagacaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 1490 <210> 15 <211> 4495 <212> DNA <213> Homo sapiens non-SMC condensin I complex, subunit H (NCAPH) <400> 15 gccggcgacg tcacgcggcc gttacggcgc tcaggcgtct cgacgcgcgc gatttaaaac 60 cagctcagga gacgccaagg aaagatggga cctcccggcc cagcactgcc agccacaatg 120 aataactctt cttcagagac gcgaggacac ccccacagtg cctcctctcc ttcagagcgt 180 gtgttcccga tgcccctgcc caggaaggcg cctctcaata ttcctggcac cccagtcctc 240 gaagactttc ctcagaatga cgatgagaag gagcggctgc agcggaggcg ctcgagggtc 300 tttgatctgc agttcagcac tgactcacct cgcttattgg cctccccctc cagcaggagt 360 attgacattt cagctactat ccccaagttt acaaacacgc agattacgga acattactcc 420 acctgtatca aactgtccac tgaaaataaa atcactacca agaatgcttt tggtttgcac 480 ttgattgatt ttatgtcaga gattcttaaa cagaaagaca ccgaaccaac caactttaaa 540 gtggctgcgg gtactctgga tgccagcacc aagatctatg ctgtgcgcgt ggatgccgtc 600 catgccgatg tatacagagt ccttgggggg ctgggcaaag atgcaccgtc tttggaagaa 660 gtagaaggcc atgttgctga tggaagtgct actgaaatgg gaacaaccaa aaaggctgta 720 aagccaaaga agaagcactt acacagaact attgagcaga acataaacaa cctcaatgtc 780 tccgaagcag atcggaagtg tgagattgat cccatgtttc agaagacagc agcctcattt 840 gatgagtgca gcacagcagg ggtgtttctg tccactctcc actgccagga ctacagaagt 900 gaactgctgt ttccctctga tgtccagact ctctccacgg gagaacctct cgagttgcca 960 gagttaggtt gtgtagaaat gacagattta aaagcgccct tgcagcagtg tgcagaagat 1020 cgccagatct gcccttccct ggccgggttc cagtttacac agtgggacag tgaaacacat 1080 aatgagtctg tgtcggccct ggtagacaag tttaagaaga atgaccaggt atttgacatc 1140 aatgctgaag ttgacgagag tgactgtgga gacttccccg atgggtccct gggggatgac 1200 tttgatgcca acgatgaacc tgaccacacc gcagttgggg atcatgaaga gttcaggagc 1260 tggaaggagc cctgccaggt tcagagctgc caggaagaaa tgatttccct tggggatgga 1320 gacatcagga ccatgtgccc ccttctgtct atgaaacctg gagaatattc ttatttcagt 1380 cctcggacca tgtcgatgtg ggctggcccg gatcactggc gctttaggcc tcgacgcaaa 1440 caagatgctc cttcccaatc agaaaacaaa aagaagagta caaaaaaaga ttttgaaatt 1500 gactttgaag atgatattga ctttgatgta tattttagaa aaacaaaggc tgctactatt 1560 ctgaccaagt ccactttgga gaaccagaat tggagagcta ccacccttcc tacagatttc 1620 aactacaatg ttgacactct ggtccagctt cacctcaaac caggcaccag gttacttaag 1680 atggcccagg gccatagggt agagactgag cattatgaag aaattgaaga ctatgattac 1740 aacaacccta acgacacctc caacttttgc cctggattac aggctgctga cagtgatgat 1800 gaagatttgg atgacttatt tgtgggacct gttgggaact ctgacctctc accttatcct 1860 tgccatccac ctaagacagc acaacagaat ggtgacactc cagaagccca aggattagac 1920 atcacaacat atggggagtc aaacttggta gctgagcctc agaaggtaaa taaaattgaa 1980 attcactatg ccaagactgc caaaaagatg gacatgaaga aactgaagca gagcatgtgg 2040 agtctgctga cagcgctctc cggaaaggag gcagatgcag aggcaaacca cagggaagct 2100 ggaaaagaag cggccctggc agaagtggct gacgagaaga tgcttagcgg gctcacgaag 2160 gacctgcaga ggagcctgcc ccctgtcatg gctcagaacc tctccatacc tctggctttt 2220 gcctgtctcc tacatttagc caatgaaaag aatctaaaac tggaaggaac agaggacctc 2280 tctgatgttc ttgtgaggca aggagattga gttcactatg gagaagtcag cagcaggagg 2340 cccatccctt actcagttgc cgggacatcc ccagtctcgg gggaagaaga tgccatgggc 2400 ttatacccag gctgtagcca actaccaacg tgcctgtttg tttgttgctc tttccttctc 2460 tccatcatag tctgggtgcc agcgccctga agctccgtgc tcaactgatt aaactttact 2520 gccctatggt gaccatctag gagaggggag ggcagagggg gtgagggtac tattctggat 2580 tgagaaaacc tatatccatt ctttatatca atgtatagtt ttagtctcct aaattgatct 2640 gttattttcc aaactattct cttgtagaaa attttccagt gggcacttaa tggtgccctt 2700 gaagaacttc ctaatccatg tacataaaat acatcatatg tacacttata aatgtatata 2760 gaatgctcaa aaataaaatt cttaataata gaactggcaa aatatttgag tgtccactag 2820 atgagtatca gacctagtcc ttacccttag ggggatgcag tcctggttgt tatccaggat 2880 acacacctgt cagtataagg cagaagatgc ctaagggcca agatggtttg cctcggagga 2940 gaatggaaga gagagattgc tgactggaca ttcagatgca agactgggtc ctgcttaaat 3000 cccaggattc tgctggaggg agctgatagt gatacttgtc ccttctgtac attgcttcat 3060 gtagccttct cagcatccct aggagaaact tactattgtg actctcatgt tggaggagga 3120 aacggacacc caaggtagag gaacttgcaa aagggcagcc ggcaaactgt caggggtggc 3180 ctgagcctgg caatctgcct ccagagtctg ctctcggcca ttgtgctatg tgctacctgg 3240 ataggtcata caggctcagc agtgggtgga gagcagtgct cagatttgtc catctccaca 3300 gaatgcagca cacacacaaa tgtacaagtt cttcccctaa cctcagagga ataggggaat 3360 taactttgct tgcaatttgg aacaatatta tagatgttga tccaagtagt tctgttactg 3420 gctggtcctg gatctctgcc agaacacccg tcatcattga ctggctaaat agagatcttg 3480 gatataggcc agaagcagtg aagtatataa ttggaaattg ctcctgataa taacttcctt 3540 cttagccaaa aaccacacaa aacaaaaata atcccctccc cacaggaata tgctttccaa 3600 attgtgtcca aaacattacc tgctctgtta tattgagaag gttagagact tcagagcatg 3660 cttagaaaaa gcagtggtgc cacaggtgag actccacact ctgtcttgct ggggctgaag 3720 cctccatcac tttcccaggc caggttagtg ctgggcttct tgctttcctt ctattcctga 3780 gagtagaact ggctaagccc attccttccc tcagtcagcc ccacttctct atagtgggtt 3840 ctgggggtgg ggggctgaat taccagtaaa actagaaaga ttgggaccaa gtgcagtggc 3900 ccacacctgt aaatcctagc gctttgaaag gaagaggcag gaggattgct tgaagtcagg 3960 agttcaagac cagcctgggc aaaatagaac cccatcttta aaaaaaaagt ttaaaaatta 4020 gccaggtacg gaggtgtgtg cctgtaatcc cagctactca gaaggctgag gtgggataat 4080 cacttgagcc caggagtttg aggctgcagt gagctgtgat cacactactg cattccagcc 4140 aggacaacag agtgagatcc tatctcttaa acaaaaaaaa aaactggcga gttcaatacc 4200 aacttctaca atgaaatccc cttcccccca caaccctgct tctcctaagt ttccctcatt 4260 acatggttgc tgtgggctat gtgtgctgtg gtctgaatgt ttgtgtctaa aattcacatg 4320 ttggtattaa gagatagggc ctttgggagg tgattaggtt atgagggcag atccctcgtg 4380 aatgggatta gtgctcttat aaaagaggcc tgaggaagct tgttcgttcc tcttgccctt 4440 ctgccatgta aggatgcaat gagaaggcac catctgtgag caaggagccc ctcac 4495 <210> 16 <211> 3749 <212> DNA <213> Homo sapiens budding uninhibited by benzimidazoles 1 homolog beta (yeast) (BUB1B) <400> 16 aggggcgtgg ccacgtcgac cgcgcgggac cgttaaattt gaaacttggc ggctaggggt 60 gtgggcttga ggtggccggt ttgttaggga gtcgtgtacg tgccttggtc gcttctgtag 120 ctccgagggc aggttgcgga agaaagccca ggcggtctgt ggcccagagg aaaggcctgc 180 agcaggacga ggacctgagc caggaatgca ggatggcggc ggtgaagaag gaagggggtg 240 ctctgagtga agccatgtcc ctggagggag atgaatggga actgagtaaa gaaaatgtac 300 aacctttaag gcaagggcgg atcatgtcca cgcttcaggg agcactggca caagaatctg 360 cctgtaacaa tactcttcag cagcagaaac gggcatttga atatgaaatt cgattttaca 420 ctggaaatga ccctctggat gtttgggata ggtatatcag ctggacagag cagaactatc 480 ctcaaggtgg gaaggagagt aatatgtcaa cgttattaga aagagctgta gaagcactac 540 aaggagaaaa acgatattat agtgatcctc gatttctcaa tctctggctt aaattagggc 600 gtttatgcaa tgagcctttg gatatgtaca gttacttgca caaccaaggg attggtgttt 660 cacttgctca gttctatatc tcatgggcag aagaatatga agctagagaa aactttagga 720 aagcagatgc gatatttcag gaagggattc aacagaaggc tgaaccacta gaaagactac 780 agtcccagca ccgacaattc caagctcgag tgtctcggca aactctgttg gcacttgaga 840 aagaagaaga ggaggaagtt tttgagtctt ctgtaccaca acgaagcaca ctagctgaac 900 taaagagcaa agggaaaaag acagcaagag ctccaatcat ccgtgtagga ggtgctctca 960 aggctccaag ccagaacaga ggactccaaa atccatttcc tcaacagatg caaaataata 1020 gtagaattac tgtttttgat gaaaatgctg atgaggcttc tacagcagag ttgtctaagc 1080 ctacagtcca gccatggata gcacccccca tgcccagggc caaagagaat gagctgcaag 1140 caggcccttg gaacacaggc aggtccttgg aacacaggcc tcgtggcaat acagcttcac 1200 tgatagctgt acccgctgtg cttcccagtt tcactccata tgtggaagag actgcacaac 1260 agccagttat gacaccatgt aaaattgaac ctagtataaa ccacatccta agcaccagaa 1320 agcctggaaa ggaagaagga gatcctctac aaagggttca gagccatcag caagcgtctg 1380 aggagaagaa agagaagatg atgtattgta aggagaagat ttatgcagga gtaggggaat 1440 tctcctttga agaaattcgg gctgaagttt tccggaagaa attaaaagag caaagggaag 1500 ccgagctatt gaccagtgca gagaagagag cagaaatgca gaaacagatt gaagagatgg 1560 agaagaagct aaaagaaatc caaactactc agcaagaaag aacaggtgat cagcaagaag 1620 agacgatgcc tacaaaggag acaactaaac tgcaaattgc ttccgagtct cagaaaatac 1680 caggaatgac tctatccagt tctgtttgtc aagtaaactg ttgtgccaga gaaacttcac 1740 ttgcggagaa catttggcag gaacaacctc attctaaagg tcccagtgta cctttctcca 1800 tttttgatga gtttcttctt tcagaaaaga agaataaaag tcctcctgca gatcccccac 1860 gagttttagc tcaacgaaga ccccttgcag ttctcaaaac ctcagaaagc atcacctcaa 1920 atgaagatgt gtctccagat gtttgtgatg aatttacagg aattgaaccc ttgagcgagg 1980 atgccattat cacaggcttc agaaatgtaa caatttgtcc taacccagaa gacacttgtg 2040 actttgccag agcagctcgt tttgtatcca ctccttttca tgagataatg tccttgaagg 2100 atctcccttc tgatcctgag agactgttac cggaagaaga tctagatgta aagacctctg 2160 aggaccagca gacagcttgt ggcactatct acagtcagac tctcagcatc aagaagctga 2220 gcccaattat tgaagacagt cgtgaagcca cacactcctc tggcttctct ggttcttctg 2280 cctcggttgc aagcacctcc tccatcaaat gtcttcaaat tcctgagaaa ctagaactta 2340 ctaatgagac ttcagaaaac cctactcagt caccatggtg ttcacagtat cgcagacagc 2400 tactgaagtc cctaccagag ttaagtgcct ctgcagagtt gtgtatagaa gacagaccaa 2460 tgcctaagtt ggaaattgag aaggaaattg aattaggtaa tgaggattac tgcattaaac 2520 gagaatacct aatatgtgaa gattacaagt tattctgggt ggcgccaaga aactctgcag 2580 aattaacagt aataaaggta tcttctcaac ctgtcccatg ggacttttat atcaacctca 2640 agttaaagga acgtttaaat gaagattttg atcatttttg cagctgttat caatatcaag 2700 atggctgtat tgtttggcac caatatataa actgcttcac ccttcaggat cttctccaac 2760 acagtgaata tattacccat gaaataacag tgttgattat ttataacctt ttgacaatag 2820 tggagatgct acacaaagca gaaatagtcc atggtgactt gagtccaagg tgtctgattc 2880 tcagaaacag aatccacgat ccctatgatt gtaacaagaa caatcaagct ttgaagatag 2940 tggacttttc ctacagtgtt gaccttaggg tgcagctgga tgtttttacc ctcagcggct 3000 ttcggactgt acagatcctg gaaggacaaa agatcctggc taactgttct tctccctacc 3060 aggtagacct gtttggtata gcagatttag cacatttact attgttcaag gaacacctac 3120 aggtcttctg ggatgggtcc ttctggaaac ttagccaaaa tatttctgag ctaaaagatg 3180 gtgaattgtg gaataaattc tttgtgcgga ttctgaatgc caatgatgag gccacagtgt 3240 ctgttcttgg ggagcttgca gcagaaatga atggggtttt tgacactaca ttccaaagtc 3300 acctgaacaa agccttatgg aaggtaggga agttaactag tcctggggct ttgctctttc 3360 agtgagctag gcaatcaagt ctcacagatt gctgcctcag agcaatggtt gtattgtgga 3420 acactgaaac tgtatgtgct gtaatttaat ttaggacaca tttagatgca ctaccattgc 3480 tgttctactt tttggtacag gtatattttg acgtcactga tattttttat acagtgatat 3540 acttactcat ggccttgtct aacttttgtg aagaactatt ttattctaaa cagactcatt 3600 acaaatggtt accttgttat ttaacccatt tgtctctact tttccctgta cttttcccat 3660 ttgtaatttg taaaatgttc tcttatgatc accatgtatt ttgtaaataa taaaatagta 3720 tctgttaaat ttgtgcttct aaaaaaaaa 3749 <210> 17 <211> 1431 <212> DNA <213> Homo sapiens centromere protein A (CENPA) <400> 17 ccgtgaagtg ggcggagcga gcgatttgaa cgcgagcggc gcggacttct gccaagcacc 60 ggctcatgtg aggctcgcgg cacagcgttc tctgggctcc ccagaagcca gcctttcgct 120 cccggacccg gcagcccgag caggagccgt gggaccgggc gccagcaccc tctgcggcgt 180 gtcatgggcc cgcgccgccg gagccgaaag cccgaggccc cgaggaggcg cagcccgagc 240 ccgaccccga cccccggccc ctcccggcgg ggcccctcct taggcgcttc ctcccatcaa 300 cacagtcggc ggagacaagg ttggctaaag gagatccgaa agcttcagaa gagcacacac 360 ctcttgataa ggaagctgcc cttcagccgc ctggcaagag aaatatgtgt taaattcact 420 cgtggtgtgg acttcaattg gcaagcccag gccctattgg ccctacaaga ggcagcagaa 480 gcatttctag ttcatctctt tgaggacgcc tatctcctca ccttacatgc aggccgagtt 540 actctcttcc caaaggatgt gcaactggcc cggaggatcc ggggccttga ggagggactc 600 ggctgagctc ctgcacccag tgtttctgtc agtctttcct gctcagccag gggggatgat 660 accggggact ctccagagcc atgactagat ccaatggatt ctgcgatgct gtctggactt 720 tgctgtctct gaacagtatg tgtgtgttgc tttaaatatt tttctttttt ttgagaagga 780 gaagactgca tgactttcct ctgtaacaga ggtaatatat gagacaatca acaccgttcc 840 aaaggcctga aaataatttt cagataaaga gactccaagg ttgactttag tttgtgagtt 900 actcatgtga ctatttgagg attttgaaaa catcagattt gctgtggtat gggagaaaag 960 gctatgtact tattatttta gctctttctg taatatttac attttttacc atatgtacat 1020 ttgtactttt attttacaca taagggaaaa aataagacca ctttgagcag ttgcctggaa 1080 ggctgggcat ttccatcata tagacctctg cccttcagag tagcctcacc attagtggca 1140 gcatcatgta actgagtgga ctgtgcttgt caacggatgt gtagcttttc agaaacttaa 1200 ttggggatga atagaaaacc tgtaagcttt gatgttctgg ttacttctag taaattcctg 1260 tcaaaatcaa ttcagaaatt ctaacttgga gaatttaaca ttttactctt gtaaatcata 1320 gaagatgtat cataacagtt cagaatttta aagtacattt tcgatgcttt tatgggtatt 1380 tttgtagttt ctttgtagag agataataaa aatcaaaata tttaatgaaa a 1431 <210> 18 <211> 2554 <212> DNA <213> Homo sapiens aurora kinase A (AURKA) <400> 18 acaaggcagc ctcgctcgag cgcaggccaa tcggctttct agctagaggg tttaactcct 60 atttaaaaag aagaaccttt gaattctaac ggctgagctc ttggaagact tgggtccttg 120 ggtcgcaggt gggagccgac gggtgggtag accgtggggg atatctcagt ggcggacgag 180 gacggcgggg acaaggggcg gctggtcgga gtggcggagc gtcaagtccc ctgtcggttc 240 ctccgtccct gagtgtcctt ggcgctgcct tgtgcccgcc cagcgccttt gcatccgctc 300 ctgggcaccg aggcgccctg taggatactg cttgttactt attacagcta gagggtctca 360 ctccattgcc caggccagag tgcggggata tttgataaga aacttcagtg aaggccgggc 420 gcggtggctc atgcccgtaa tcccagcatt ttcggaggcc gaggctggag tgcaatggtg 480 tgatctcagc tcactgcaac ctctgcttcc tgggtttaag tgattctcct gcctcagcct 540 cccgagtagc tgggattaca ggcatcatgg accgatctaa agaaaactgc atttcaggac 600 ctgttaaggc tacagctcca gttggaggtc caaaacgtgt tctcgtgact cagcaatttc 660 cttgtcagaa tccattacct gtaaatagtg gccaggctca gcgggtcttg tgtccttcaa 720 attcttccca gcgcattcct ttgcaagcac aaaagcttgt ctccagtcac aagccggttc 780 agaatcagaa gcagaagcaa ttgcaggcaa ccagtgtacc tcatcctgtc tccaggccac 840 tgaataacac ccaaaagagc aagcagcccc tgccatcggc acctgaaaat aatcctgagg 900 aggaactggc atcaaaacag aaaaatgaag aatcaaaaaa gaggcagtgg gctttggaag 960 actttgaaat tggtcgccct ctgggtaaag gaaagtttgg taatgtttat ttggcaagag 1020 aaaagcaaag caagtttatt ctggctctta aagtgttatt taaagctcag ctggagaaag 1080 ccggagtgga gcatcagctc agaagagaag tagaaataca gtcccacctt cggcatccta 1140 atattcttag actgtatggt tatttccatg atgctaccag agtctaccta attctggaat 1200 atgcaccact tggaacagtt tatagagaac ttcagaaact ttcaaagttt gatgagcaga 1260 gaactgctac ttatataaca gaattggcaa atgccctgtc ttactgtcat tcgaagagag 1320 ttattcatag agacattaag ccagagaact tacttcttgg atcagctgga gagcttaaaa 1380 ttgcagattt tgggtggtca gtacatgctc catcttccag gaggaccact ctctgtggca 1440 ccctggacta cctgccccct gaaatgattg aaggtcggat gcatgatgag aaggtggatc 1500 tctggagcct tggagttctt tgctatgaat ttttagttgg gaagcctcct tttgaggcaa 1560 acacatacca agagacctac aaaagaatat cacgggttga attcacattc cctgactttg 1620 taacagaggg agccagggac ctcatttcaa gactgttgaa gcataatccc agccagaggc 1680 caatgctcag agaagtactt gaacacccct ggatcacagc aaattcatca aaaccatcaa 1740 attgccaaaa caaagaatca gctagcaaac agtcttagga atcgtgcagg gggagaaatc 1800 cttgagccag ggctgccata taacctgaca ggaacatgct actgaagttt attttaccat 1860 tgactgctgc cctcaatcta gaacgctaca caagaaatat ttgttttact cagcaggtgt 1920 gccttaacct ccctattcag aaagctccac atcaataaac atgacactct gaagtgaaag 1980 tagccacgag aattgtgcta cttatactgg ttcataatct ggaggcaagg ttcgactgca 2040 gccgccccgt cagcctgtgc taggcatggt gtcttcacag gaggcaaatc cagagcctgg 2100 ctgtggggaa agtgaccact ctgccctgac cccgatcagt taaggagctg tgcaataacc 2160 ttcctagtac ctgagtgagt gtgtaactta ttgggttggc gaagcctggt aaagctgttg 2220 gaatgagtat gtgattcttt ttaagtatga aaataaagat atatgtacag acttgtattt 2280 tttctctggt ggcattcctt taggaatgct gtgtgtctgt ccggcacccc ggtaggcctg 2340 attgggtttc tagtcctcct taaccactta tctcccatat gagagtgtga aaaataggaa 2400 cacgtgctct acctccattt agggatttgc ttgggataca gaagaggcca tgtgtctcag 2460 agctgttaag ggcttatttt tttaaaacat tggagtcata gcatgtgtgt aaactttaaa 2520 tatgcaaata aataagtatc tatgtctaaa aaaa 2554 <210> 19 <211> 3950 <212> DNA <213> Homo sapiens non-SMC condensin II complex, subunit G2 (NCAPG2) <400> 19 gagagcggcg cctgatgacg accgggaggg cggggcccgt ctggggcgcc ggcgggtgcg 60 tttgaatctg gtccgagcgc gggaaacggc gggtccccga gcccagggtt acaaaataaa 120 tgccatttga acagtgccat ctgtcatgga aaaacgtgag acgtttgtac aagccgtgtc 180 taaggagctg gttggagagt ttttgcaatt tgttcaactt gataaagagg cctctgatcc 240 tttcagccta aatgaattac tagatgaatt atcaaggaaa cagaaagaag aattatggca 300 aaggctgaag aatttattga cagatgtgtt gttagaaagc ccagtggatg ggtggcaggt 360 agtggaagcc cagggtgaag acaatatgga aaccgaacat ggctcaaaaa tgagaaaaag 420 catagaaata atttatgcaa ttacatctgt gattcttgct tctgtgtctg taataaatga 480 aagtgagaac tacgaagccc tactggaatg tgttattata ttaaatggta ttttatatgc 540 attacctgag tctgaacgaa aactacagag ttctattcag gatttgtgtg ttacctggtg 600 ggagaaaggc ctgcctgcca aggaagacac aggaaagaca gcctttgtca tgttactaag 660 gaggagtctg gagactaaga caggtgcaga cgtatgtcgg ctttggcgta tccatcaagc 720 tttatattgc tttgattatg atttggagga aagtggagaa attaaagata tgttacttga 780 gtgcttcata aatattaatt atatcaagaa agaagaggga agaagatttc ttagttgtct 840 cttcaactgg aatatcaact tcatcaaaat gatccacggg accattaaaa accagttaca 900 gggattacaa aagtctttga tggtatacat tgcagaaatt tatttcagag cttggaaaaa 960 ggcttcaggg aaaatactgg aggcgattga aaatgattgc atccaggact tcatgttcca 1020 cgggatacac cttccgagga ggtctccagt gcattccaaa gtgcgggagg ttctgagtta 1080 ctttcaccat caaaagaaag ttcggcaggg agtggaagag atgctttata gattatataa 1140 gcccatcctt tggagaggat taaaggccag aaactctgaa gttcgatcaa atgctgcatt 1200 gttgtttgtt gaagcatttc ctattaggga tccaaacctt catgctattg aaatggatag 1260 tgaaatccag aaacagtttg aagagctcta tagcctttta gaagatcctt acccgatggt 1320 ccgttccaca gggatccttg gtgtttgtaa aataacttct aagtactggg aaatgatgcc 1380 cccgaccatt cttattgacc tcctgaagaa ggtgactggg gaactggcat ttgacacgag 1440 ctcagctgat gttcgttgtt ctgtctttaa gtgtctgcca atgattttgg acaacaaact 1500 gagccaccca ttgttagagc agctccttcc agctctcaga tacagtctcc acgacaattc 1560 ggagaaagtg agggtagctt ttgtggacat gctgttgaag atcaaagctg tgagggctgc 1620 taagttttgg aaaatatgtc ccatggagca cattctggtt cgtctggaaa ctgattctcg 1680 acctgtgtct cggcgcctgg tgagcctcat ctttaattct ttcctgcctg tgaatcagcc 1740 ggaggaggtc tggtgcgagc gctgtgtcac cctggtgcag atgaaccacg ccgctgccag 1800 gaggttctat cagtacgccc acgaacacac cgcctgcacc aacatagcaa agctgattca 1860 cgttattcgt cattgcttaa atgcctgtat ccagagggca gtgagagagc ctccagagga 1920 cgaggaggaa gaggacggaa gggagaagga gaatgtgact gttctggaca aaacactgtc 1980 agtaaacgat gttgcatgca tggcaggttt actagaaatc attgtgattc tctggaaaag 2040 tattgacaga agtatggaaa ataataaaga ggccaaactt tacacgatta acaagtttgc 2100 ctctgtgctt ccagagtatc tgaaagtatt taaggatgat cgctgcaaga tccctttatt 2160 catgctaatg tcctttatgc cggcctctgc tgtcccccca ttcagctgtg gtgtgatttc 2220 cacgctgaga agccgggagg agggcgctgt ggacaagagc tactgcactt tgttggattg 2280 cctctgctcc tgggggcagg tggggcacat tctggagctt gttgacaact ggctgcccac 2340 agagcatgcc caggccaaga gcaacacagc ttctaaaggt agggtgcaga tccatgacac 2400 acgcccagtc aaacctgaat tggcattggt ctacattgag tatctgctga ctcatccaaa 2460 gaaccgcgag tgcttgctct ctgctcctcg gaagaaactt aaccatcttt tgaaagccct 2520 tgaaacgtca aaggcagatc tggagtcact tctgcagaca ccgggtggga agcctcgtgg 2580 cttcagtgaa gcagctgccc cgcgagcctt tggtctccac tgtcgcctga gcatccatct 2640 tcagcacaag ttctgctcag aaggaaaggt gtatttgtcc atgttggaag acactggctt 2700 ttggttagaa agcaaaattt tatcttttat tcaagatcaa gaagaagact acctgaagct 2760 tcatagggtc atttatcagc aaattatcca gacctacctg actgtgtgta aagatgttgt 2820 tatggtaggc cttggtgacc atcagtttca gatgcaactc ttacagcgga gtcttggaat 2880 catgcaaaca gtgaagggat ttttttatgt ttcattactt cttgacattc tgaaagagat 2940 aactggaagt tccttgattc agaaaacaga ttcagatgaa gaagttgcaa tgctgttgga 3000 cacagtccag aaagtatttc agaaaatgtt ggaatgtatt gcacggagct tcaggaagca 3060 gccggaagaa ggcctgcggc tgctttattc tgttcagagg cctcttcatg agttcattac 3120 tgctgttcag tctcggcaca cagacacccc tgtgcaccgg ggtgtacttt ctactctgat 3180 cgctgggcct gtggttgaga taagtcacca gctacggaag gtttctgacg tagaagagct 3240 tacccctcca gagcatcttt ctgatcttcc accattttca aggtgtttaa taggaataat 3300 aataaagtct tcgaatgtgg tcaggtcatt tttggatgaa ttaaaggcat gtgtggcttc 3360 taatgatatt gaaggcattg tgtgcctcac ggctgctgtg catattatcc tggttattaa 3420 tgcaggtaaa cataaaagct caaaagtgag ggaggttgca gccactgttc acagaaaact 3480 aaagacattc atggaaatta ctttggaaga ggatagcatt gaaagatttc tctatgaatc 3540 atcatcaaga actctgggag aacttttgaa ttcataacca agccaacatc tccagacatg 3600 taaaaatagg gaaaagtgat tcaaattgaa atgcctgtgt attttcctat tgtttttaat 3660 gttaataacc catataatag ggaaagggtg ggattttttt gtgggaatgt gggaaggtgg 3720 gggttatgga ggagataact caaaacttct tcaattttgc ctagtgcctg cgtaaataat 3780 atatttaata taaaggactc caggtatgaa tggtgtagaa atccatgatt ccaagaaaaa 3840 acacttttct agcaaacctg gttgttttta aaatgacttt tatatatgta atattgcttg 3900 gaaactatga gtaataaagc aatgacaaca tcaaaaaaaa aaaaaaaaaa 3950 <210> 20 <211> 2161 <212> DNA <213> Homo sapiens NIMA (never in mitosis gene a)-related kinase 2 (NEK2) <400> 20 gcgacggtta aacggggccc aaggcagggg tggcgggtca gtgctgctcg ggggcttctc 60 catccaggtc cctggagttc ctggtccctg gagctccgca cttggcggcg caacctgcgt 120 gaggcagcgc gactctggcg actggccggc catgccttcc cgggctgagg actatgaagt 180 gttgtacacc attggcacag gctcctacgg ccgctgccag aagatccgga ggaagagtga 240 tggcaagata ttagtttgga aagaacttga ctatggctcc atgacagaag ctgagaaaca 300 gatgcttgtt tctgaagtga atttgcttcg tgaactgaaa catccaaaca tcgttcgtta 360 ctatgatcgg attattgacc ggaccaatac aacactgtac attgtaatgg aatattgtga 420 aggaggggat ctggctagtg taattacaaa gggaaccaag gaaaggcaat acttagatga 480 agagtttgtt cttcgagtga tgactcagtt gactctggcc ctgaaggaat gccacagacg 540 aagtgatggt ggtcataccg tattgcatcg ggatctgaaa ccagccaatg ttttcctgga 600 tggcaagcaa aacgtcaagc ttggagactt tgggctagct agaatattaa accatgacac 660 gagttttgca aaaacatttg ttggcacacc ttattacatg tctcctgaac aaatgaatcg 720 catgtcctac aatgagaaat cagatatctg gtcattgggc tgcttgctgt atgagttatg 780 tgcattaatg cctccattta cagcttttag ccagaaagaa ctcgctggga aaatcagaga 840 aggcaaattc aggcgaattc cataccgtta ctctgatgaa ttgaatgaaa ttattacgag 900 gatgttaaac ttaaaggatt accatcgacc ttctgttgaa gaaattcttg agaacccttt 960 aatagcagat ttggttgcag acgagcaaag aagaaatctt gagagaagag ggcgacaatt 1020 aggagagcca gaaaaatcgc aggattccag ccctgtattg agtgagctga aactgaagga 1080 aattcagtta caggagcgag agcgagctct caaagcaaga gaagaaagat tggagcagaa 1140 agaacaggag ctttgtgttc gtgagagact agcagaggac aaactggcta gagcagaaaa 1200 tctgttgaag aactacagct tgctaaagga acggaagttc ctgtctctgg caagtaatcc 1260 agaacttctt aatcttccat cctcagtaat taagaagaaa gttcatttca gtggggaaag 1320 taaagagaac atcatgagga gtgagaattc tgagagtcag ctcacatcta agtccaagtg 1380 caaggacctg aagaaaaggc ttcacgctgc ccagctgcgg gctcaagccc tgtcagatat 1440 tgagaaaaat taccaactga aaagcagaca gatcctgggc atgcgctagc caggtagaga 1500 gacacagagc tgtgtacagg atgtaatatt accaaccttt aaagactgat attcaaatgc 1560 tgtagtgttg aatacttggt tccatgagcc atgcctttct gtatagtaca catgatattt 1620 cggaattggt tttactgttc ttcagcaact attgtacaaa atgttcacat ttaatttttc 1680 tttcttcttt taagaacata ttataaaaag aatactttct tggttgggct tttaatcctg 1740 tgtgtgatta ctagtaggaa catgagatgt gacattctaa atcttgggag aaaaaataat 1800 gttaggaaaa aaatatttat gcaggaagag tagcactcac tgaatagttt taaatgactg 1860 agtggtatgc ttacaattgt catgtctaga tttaaatttt aagtctgaga ttttaaatgt 1920 ttttgagctt agaaaaccca gttagatgca atttggtcat taataccatg acatcttgct 1980 tataaatatt ccattgctct gtagttcaaa tctgttagct ttgtgaaaat tcatcactgt 2040 gatgtttgta ttcttttttt ttttctgttt aacagaatat gagctgtctg tcatttacct 2100 acttctttcc cactaaataa aagaattctt cagtttccct gtaaaaaaaa aaaaaaaaaa 2160 a 2161 <210> 21 <211> 2927 <212> DNA <213> Homo sapiens spindle and kinetochore associated complex subunit 3 (SKA3) <400> 21 gagaggactg cgcctgcgca gagccgagga cgcgtccggc gccgagattc aaactagtgg 60 cgggaggctg tgagctgagc ggtggggtct gcgtacgcct ggagtccttc cccgctgtgc 120 tcagcatgga ccctatccgg agcttctgcg ggaagctgcg gtctctggcc agcacgctgg 180 actgcgagac ggcccggctg cagcgagcgc tggacggaga ggaaagcgac tttgaagatt 240 atccaatgag aattttatat gaccttcatt cagaagttca gactctaaag gatgatgtta 300 atattcttct tgataaagca agattggaaa atcaagaagg cattgatttc ataaaggcaa 360 caaaagtact aatggaaaaa aattcaatgg atattatgaa aataagagag tatttccaga 420 agtatggata tagtccacgt gtcaagaaaa attcagtaca cgagcaagaa gccattaact 480 ctgacccaga gttgtctaat tgtgaaaatt ttcagaagac tgatgtgaaa gatgatctgt 540 ctgatcctcc tgttgcaagc agttgtattt ctgagaagtc tccacgtagt ccacaacttt 600 cagattttgg acttgagcgg tacatcgtat cccaagttct accaaaccct ccacaggcag 660 tgaacaacta taaggaagag cccgtaattg taaccccacc taccaaacaa tcactagtaa 720 aagtactaaa aactccaaaa tgtgcactaa aaatggatga ttttgagtgt gtaactccta 780 aattagaaca ctttggtatc tctgaatata ctatgtgttt aaatgaagat tacacaatgg 840 gacttaaaaa tgcgaggaat aataaaagtg aggaggccat agatacagaa tccaggctca 900 atgataatgt ttttgccact cccagcccca tcatccagca gttggaaaaa agtgatgccg 960 aatataccaa ctctcctttg gtacctacat tctgtactcc tggtttgaaa attccatcta 1020 caaagaacag catagctttg gtatccacaa attacccatt atcaaaaaca aatagttcat 1080 caaatgattt ggaagttgaa gatcgtactt cgttggtttt aaattcagac acatgctttg 1140 agaatttaac agatccctct tcacctacga tttcttctta tgagaatctg ctcagaacac 1200 ctacacctcc ggaagtaact aaaattccag aagatattct ccagctttta tcaaaataca 1260 actcaaacct agctactcca atagcaatta aagcagtgcc acccagtaaa aggttcctta 1320 aacatggaca gaacatccga gatgtcagca acaaagaaaa ctgaaattcc agtggatcta 1380 tccaacacag aaactgaaca aaatgagatg aaagccgagc tggaccgatt ttaacattca 1440 cattgccctg cctctgtccc cctttaaacg ttgacccatt ttaaagacaa acatgaacat 1500 taacatcata atatgctttt tatgaagttt caataaggtt taaccttagt cttgttgaca 1560 tgtagcccag tcattcactc tttaaggatt attagtgttt cattgatact aaattaccca 1620 gcttaatcaa cagaatggtt taagtagtac caggaagtag gacaagtaat ttcaaaaata 1680 taaaggtgtt tgctactcag atgaggccgc ccctgacctt ctggccagag agacattgct 1740 gccagccagc tctgccttcc catcatctcc tttcaggacc gtcccacacc ttttacttgc 1800 tcagtgctgt ctgaagatgc agttgctgtt tgcaaacaac aggaacacca gttaaactaa 1860 ttaggaaaag agggagattt ccaggcctgg gtaactatat actgtgacca ttggaggtag 1920 agacaggtct caacagttgg aaccaggaac tctgctgtca ggttgagagt tttgtttctc 1980 ttccagcttt tcactgtgtg ggggtctttt ctcttatgtc agctctttct atcacatggc 2040 agctgacctc tcacgctcca ctctgcagct tggacaccca gtagaccctg aatttcactc 2100 tctctaaaag gttctgaggg ctcatcctgg gccaggggcc ctcctgtgca ctgttagcta 2160 tggccacggg agcctccaga gctgcctggt agcttcaggt tgacctgctt atcaggccta 2220 cgatccttct gatttaagta cagctggaaa gtattatcta attaagttca tgatagtgct 2280 tttggagaac ttgtcaaatt acagccaatg agaaaataag gacctagcat actgtggaga 2340 accattaaaa atttgagaag aaacaacaag tattatgtca acttacttca aaggcgtagt 2400 tttgggaatt tgatgcagta aagattaccc tgttttatga ttgttccttg aaagtcaaat 2460 gggggacctg tccattgtgc tctattaatc ttgtcagaaa actgtcacca aaacaaaact 2520 tgagtttgtc cttgttctag gagttactgg gtagttgtaa gtattatttt tattaaatat 2580 aatgtaaaat aaaatgttaa gatacttagt tttgtttttc aaagtaaagc tgtagtcagc 2640 cttatgtatg ccattgactc tgaaatgtat accagccttt cactgtgtac cgtgtgtata 2700 taaatccaca gaaccggatg agctgcttag ggagggaata tattcaaagt gtaccaagga 2760 ccaaatcctg gagttctccc aactttagag gatggaaagg ggcagagtaa tctagcaaag 2820 gagactgagg ccagtgaagt aggaagaaag tatttcaagg agagtgatga ttctgtgaat 2880 attgctgaga attcaaataa aaagaggact gagaactgaa aaaaaaa 2927 <210> 22 <211> 3870 <212> DNA <213> Homo sapiens polo-like kinase 4 (PLK4) <400> 22 agcctatccg gagcgatcca tctcgttacg tcaccaccag cctagctcgg acggcaagcg 60 gcgggagatt ttcaaaatgg gagcccagag gcaccgccca ggcctcggaa ggtgtcaggg 120 agaactttcc gtggtttcag cgtcgtcgcc tggagcggcg gtttagagag ccgagcctga 180 tgggcgccaa ggccggctgg ctgcttggag cgctgcctcg aagggactgc gtgaaggaag 240 ctaatccgga gaacccaggc cagagcctgg aaatatggcg acctgcatcg gggagaagat 300 cgaggatttt aaagttggaa atctgcttgg taaaggatca tttgctggtg tctacagagc 360 tgagtccatt cacactggtt tggaagttgc aatcaaaatg atagataaga aagccatgta 420 caaagcagga atggtacaga gagtccaaaa tgaggtgaaa atacattgcc aattgaaaca 480 tccttctatc ttggagcttt ataactattt tgaagatagc aattatgtgt atctggtatt 540 agaaatgtgc cataatggag aaatgaacag gtatctaaag aatagagtga aacccttctc 600 agaaaatgaa gctcgacact tcatgcacca gatcatcaca gggatgttgt atcttcattc 660 tcatggtata ctacaccggg acctcacact ttctaacctc ctactgactc gtaatatgaa 720 catcaagatt gctgattttg ggctggcaac tcaactgaaa atgccacatg aaaagcacta 780 tacattatgt ggaactccta actacatttc accagaaatt gccactcgaa gtgcacatgg 840 ccttgaatct gatgtttggt ccctgggctg tatgttttat acattactta tcgggagacc 900 acccttcgac actgacacag tcaagaacac attaaataaa gtagtattgg cagattatga 960 aatgccatct tttttgtcaa tagaggccaa ggaccttatt caccagttac ttcgtagaaa 1020 tccagcagat cgtttaagtc tgtcttcagt attggaccat ccttttatgt cccgaaattc 1080 ttcaacaaaa agtaaagatt taggaactgt ggaagactca attgatagtg ggcatgccac 1140 aatttctact gcaattacag cttcttccag taccagtata agtggtagtt tatttgacaa 1200 aagaagactt ttgattggtc agccactccc aaataaaatg actgtatttc caaagaataa 1260 aagttcaact gatttttctt cttcaggaga tggaaacagt ttttatactc agtggggaaa 1320 tcaagaaacc agtaatagtg gaaggggaag agtaattcaa gatgcagaag aaaggccaca 1380 ttctcgatac cttcgtagag cttattcctc tgatagatct ggcacttcta atagtcagtc 1440 tcaagcaaaa acatatacaa tggaacgatg tcactcagca gaaatgcttt cagtgtccaa 1500 aagatcagga ggaggtgaaa atgaagagag gtactcaccc acagacaaca atgccaacat 1560 ttttaacttc tttaaagaaa agacatccag tagttctgga tcttttgaaa gacctgataa 1620 caatcaagca ctctccaatc atctttgtcc aggaaaaact ccttttccat ttgcagaccc 1680 gacacctcag actgaaaccg tacaacagtg gtttgggaat ctgcaaataa atgctcattt 1740 aagaaaaact actgaatatg acagcatcag cccaaaccgg gacttccagg gccatccaga 1800 tttgcagaag gacacatcaa aaaatgcctg gactgataca aaagtcaaaa agaactctga 1860 tgcttctgat aatgcacatt ctgtaaaaca gcaaaatacc atgaaatata tgactgcact 1920 tcacagtaaa cctgagataa tccaacaaga atgtgttttt ggctcagatc ctctttctga 1980 acagagcaag actaggggta tggagccacc atggggttat cagaatcgta cattaagaag 2040 cattacatct ccgttggttg ctcacaggtt aaaaccaatc agacagaaaa ccaaaaaggc 2100 tgtggtgagc atacttgatt cagaggaggt gtgtgtggag cttgtaaagg agtatgcatc 2160 tcaagaatat gtgaaagaag ttcttcagat atctagtgat ggaaatacga tcactattta 2220 ttatccaaat ggtggtagag gttttcctct tgctgataga ccaccctcac ctactgacaa 2280 catcagtagg tacagctttg acaatttacc agaaaaatac tggcgaaaat atcaatatgc 2340 ttccaggttt gtacagcttg taagatctaa atctcccaaa atcacttatt ttacaagata 2400 tgctaaatgc attttgatgg agaattctcc tggtgctgat tttgaggttt ggttttatga 2460 tggggtaaaa atacacaaaa cagaagattt cattcaggtg attgaaaaga cagggaagtc 2520 ttacacttta aaaagtgaaa gtgaagttaa tagcttgaaa gaggagataa aaatgtatat 2580 ggaccatgct aatgagggtc atcgtatttg tttagcactg gaatccataa tttcagaaga 2640 ggaaaggaaa actaggagtg ctcccttttt cccaataatc ataggaagaa aacctggtag 2700 tactagttca cctaaggcct tatcacctcc tccttctgtg gattcaaatt acccaacgag 2760 agagagagca tctttcaaca gaatggtcat gcatagtgct gcttctccaa cacaggcacc 2820 aatccttaat ccctctatgg ttacaaatga aggacttggt cttacaacta cagcttctgg 2880 aacagacatc tcttctaata gtctaaaaga ttgtcttcct aaatcagcac aacttttgaa 2940 atctgttttt gtgaaaaatg ttggttgggc tacacagtta actagtggag ctgtgtgggt 3000 tcagtttaat gatgggtccc agttggttgt gcaggcagga gtgtcttcta tcagttatac 3060 ctcaccaaat ggtcaaacaa ctaggtatgg agaaaatgaa aaattaccag actacatcaa 3120 acagaaatta cagtgtctgt cttccatcct tttgatgttt tctaatccga ctcctaattt 3180 tcattgatta aaactccttt cagacatata agtttaataa ataacttttt tgttgacttt 3240 caagtaaagt gatttttttt aatttaacat aaagtcttca gaaagccttt ctatgaaaga 3300 attttaacct ataatgtaaa ggatgtattc tgagagaaca aagcagaatg aaacttgagt 3360 cacttactaa atatagtgga tataaaatag aacacctgac tttgctctta gaccataacc 3420 cccgaactta ctatgttcat atatttgtat tgaacaatct tttaaaagca aaaatgtaaa 3480 tgatgtgtag tttatttgtg cttttattgt tttccctgcg tctcagacat gttgagaatc 3540 atggacaaaa cctgctggaa ttttggaatt tttgaagatg taaataatgt gtatttatgt 3600 tataagtaac atatgtaaac atgtatattt gttttatatt tatttttgta acaccagtgt 3660 ctgatgaaac atttttgcaa atgcatttta taaaaaaata aatatagtga taagttacat 3720 tatcttttga ttcatttaat taaatactta tttttaaata acttaccagt aaactcactt 3780 tttaaatttt gttgcctgtt gaggagccaa ttaaatttta aatattaatt ttgcaaatgt 3840 taaatacatt gtttctctat tatctgaaaa 3870 <210> 23 <211> 1644 <212> DNA <213> Homo sapiens origin recognition complex, subunit 6 (ORC6) <400> 23 gcgcgcgggt ttcgttgacc cgcggcgttc acgggaattg ttcgctttag tgccggcgcc 60 atggggtcgg agctgatcgg gcgcctagcc ccgcgcctgg gcctcgccga gcccgacatg 120 ctgaggaaag cagaggagta cttgcgcctg tcccgggtga agtgtgtcgg cctctccgca 180 cgcaccacgg agaccagcag tgcagtcatg tgcctggacc ttgcagcttc ctggatgaag 240 tgccccttgg acagggctta tttaattaaa ctttctggtt tgaacaagga gacatatcag 300 agctgtctta aatcttttga gtgtttactg ggcctgaatt caaatattgg aataagagac 360 ctagctgtac agtttagctg tatagaagca gtgaacatgg cttcaaagat actaaaaagc 420 tatgagtcca gtcttcccca gacacagcaa gtggatcttg acttatccag gccacttttc 480 acttctgctg cactgctttc agcatgcaag attctaaagc tgaaagtgga taaaaacaaa 540 atggtagcca catccggtgt aaaaaaagct atatttgatc gactgtgtaa acaactagag 600 aagattggac agcaggtcga cagagaacct ggagatgtag ctactccacc acggaagaga 660 aagaagatag tggttgaagc cccagcaaag gaaatggaga aggtagagga gatgccacat 720 aaaccacaga aagatgaaga tctgacacag gattatgaag aatggaaaag aaaaattttg 780 gaaaatgctg ccagtgctca aaaggctaca gcagagtgat ttcagcttcc aaactggtat 840 acattccaaa ctgatagtac attgccatct ccaggaagac ttgacggctt tgggattttg 900 tttaaacttt tataataagg atcctaagac tgttgccttt aaatagcaaa gcagcctacc 960 tggaggctaa gtctgggcag tgggctggcc cctggtgtga gcattagacc agccacagtg 1020 cctgattggt atagccttat gtgctttcct acaaaatgga attggaggcc gggcgcagtg 1080 gctcacgcct gtaatcccag cactttggga ggccaaggtg ggtggatcac ctgaggtcag 1140 gagctcgaga ccagcctggc caacatggtg aaaccccatc tctactaaaa atacaaaaat 1200 tagccaggtg tgatggtgca tgcctgtaat cccagctcct cagtaggctg agacaggagc 1260 atcacttgaa cgtgggaggc agaggttgca gtgagccgag attgcaccac cgcactccag 1320 cctgggtgac agagcgagac ttatctcata aataaataga tagatactcc agcctgggtg 1380 acagagcgag acttatagat agatagatag atagatggat agatagatag atagatagat 1440 agatagataa acggaattgg agccattttg ctttaagtga atggcagtcc cttgtcttat 1500 tcagaatata aaattcagtc tgaatggcat cttacagatt ttacttcaat ttttgtgtac 1560 ggtatttttt atttgactaa atcaatatat tgtacagcct aagttaataa atgttattta 1620 tatatgcaaa aaaaaaaaaa aaaa 1644 <210> 24 <211> 2319 <212> DNA <213> Homo sapiens cell division cycle associated 8 (CDCA8) <400> 24 gtggagtttg aattgggtgg cggttgactg tagagccgct ctctctcact ggcacagcga 60 ggttttgctc agcccttgtc tcgggaccgc agcctccgcc gagcgccatg gctcctagga 120 agggcagtag tcgggtggcc aagaccaact ccttacggag gcggaagctc gcctcctttc 180 tgaaagactt cgaccgtgaa gtggaaatac gaatcaagca aattgagtca gacaggcaga 240 acctcctcaa ggaggtggat aacctctaca acatcgagat cctgcggctc cccaaggctc 300 tgcgcgagat gaactggctt gactacttcg cccttggagg aaacaaacag gccctggaag 360 aggcggcaac agctgacctg gatatcaccg aaataaacaa actaacagca gaagctattc 420 agacacccct gaaatctgcc aaaacacgaa aggtaataca ggtagatgaa atgatagtgg 480 aagaggaaga agaagaagaa aatgaacgta agaatcttca aactgcaaga gtcaaaaggt 540 gtcctccatc caagaagaga actcagtcca tacaaggaaa aggaaaaggg aaaaggtcaa 600 gccgtgctaa cactgttacc ccagccgtgg gccgattgga ggtgtccatg gtcaaaccaa 660 ctccaggcct gacacccagg tttgactcaa gggtcttcaa gacccctggc ctgcgtactc 720 cagcagcagg agagcggatt tacaacatct cagggaatgg cagccctctt gctgacagca 780 aagagatctt cctcactgtg ccagtgggcg gcggagagag cctgcgatta ttggccagtg 840 acttgcagag gcacagtatt gcccagctgg atccagaggc cttgggaaac attaagaagc 900 tctccaaccg tctcgcccaa atctgcagca gcatacggac ccacaaatga gacaccaaag 960 ttgacaggat ggacttttaa tgggcacttc tgggaccctg aagagacttc ttcccttcag 1020 gcttattgtt tgagtgtgaa gttccagagc aaggagccat gttcctctaa gggaattcag 1080 gaattcagac gtgctagtcc cacaccagtt aggtagagct gtctgttcac cctcccatcc 1140 cagctgatcc cagtcactgc ttgctggggc catgccatgg aagcttccca tcagtctccc 1200 agctgaatcc tccctgctct ctgagctgct gccttttgcc tcctgcaact caacatcctc 1260 ttcaccctgc cctgcctgca gttgaggggg cgaagaagaa ccctgtgttc tcaggaagac 1320 tgcctccacc accgctaccc agagaacctc tgcatctggc atttctgctc tctatgcttg 1380 agaccgggag gtttaggctc agataagtga gctctgggcc atgagagggt aggtccagaa 1440 ggtgggggga actgtacaga tcagcagagc aggacagttg gcagcagtga cctcagtagg 1500 gaacatgtcc gtctaccctc tcgcactcat gacacctccc cctaccagcc ctcctcttcc 1560 tcctcctcct cctcctgtgg gaggtggtca gtgggactta gggatctttc acctgctgtg 1620 cccagtagtt ctgaagtctg cttgtggagc agtgttttat gtttatccct gtttactgaa 1680 gaccaaatac tggtttggag acaacttcca tgtcttgctc ttctacctcc ctagttagtg 1740 gaaatttgga taagggaact gtagggccca gattctggag gttttatgtc attggccaca 1800 gaataactgt ctctaagcta tccatggtcc agtggtccct gccaagtctg tagacttcag 1860 agagcacttc tctcttatgg ggttcatggg aacaggggtg ggtgtgactt gcttggtggc 1920 ctcattccat gtgtgcctgt gcctggggca tggactttgt taagcagagt cagcagtgag 1980 gtcctcattc tccagccagc ctctctgccc tggagaatca tgtgctatgt tctaagaatt 2040 tgagaactag agtcctcatc cccaggcttg aaggcacatg gctttctcat gtagggctct 2100 ctgtggtatt tgttattatt ttgcaacaag accattttag taaaacagtc ctgttcaagt 2160 tgtattcttt taagttcttt tattctcctt tccctgagat ttttgtatat attgttctga 2220 gtaatggtat ctttgagctg attgttctaa tcagagctgg tacctacttt caataaattc 2280 tggttttgtg ttttcttttg taaaaaaaaa aaaaaaaaa 2319 <210> 25 <211> 5356 <212> DNA <213> Homo sapiens DEP domain containing 1 (DEPDC1) <400> 25 tatgctattc aaatcggcgg cggggccaac ggttgtgccg agactcgcca ctgccgcggc 60 cgctgggcct gagtgtcgcc ttcgccgcca tggacgccac cgggcgctga cagacctatg 120 gagagtcagg gtgtgcctcc cgggccttat cgggccacca agctgtggaa tgaagttacc 180 acatcttttc gagcaggaat gcctctaaga aaacacagac aacactttaa aaaatatggc 240 aattgtttca cagcaggaga agcagtggat tggctttatg acctattaag aaataatagc 300 aattttggtc ctgaagttac aaggcaacag actatccaac tgttgaggaa atttcttaag 360 aatcatgtaa ttgaagatat caaagggagg tggggatcag aaaatgttga tgataacaac 420 cagctcttca gatttcctgc aacttcgcca cttaaaactc taccacgaag gtatccagaa 480 ttgagaaaaa acaacataga gaacttttcc aaagataaag atagcatttt taaattacga 540 aacttatctc gtagaactcc taaaaggcat ggattacatt tatctcagga aaatggcgag 600 aaaataaagc atgaaataat caatgaagat caagaaaatg caattgataa tagagaacta 660 agccaggaag atgttgaaga agtttggaga tatgttattc tgatctacct gcaaaccatt 720 ttaggtgtgc catccctaga agaagtcata aatccaaaac aagtaattcc ccaatatata 780 atgtacaaca tggccaatac aagtaaacgt ggagtagtta tactacaaaa caaatcagat 840 gacctccctc actgggtatt atctgccatg aagtgcctag caaattggcc aagaagcaat 900 gatatgaata atccaactta tgttggattt gaacgagatg tattcagaac aatcgcagat 960 tattttctag atctccctga acctctactt acttttgaat attacgaatt atttgtaaac 1020 attttggttg tttgtggcta catcacagtt tcagatagat ccagtgggat acataaaatt 1080 caagatgatc cacagtcttc aaaattcctt cacttaaaca atttgaattc cttcaaatca 1140 actgagtgcc ttcttctcag tctgcttcat agagaaaaaa acaaagaaga atcagattct 1200 actgagagac tacagataag caatccagga tttcaagaaa gatgtgctaa gaaaatgcag 1260 ctagttaatt taagaaacag aagagtgagt gctaatgaca taatgggagg aagttgtcat 1320 aatttaatag ggttaagtaa tatgcatgat ctatcctcta acagcaaacc aaggtgctgt 1380 tctttggaag gaattgtaga tgtgccaggg aattcaagta aagaggcatc cagtgtcttt 1440 catcaatctt ttccgaacat agaaggacaa aataataaac tgtttttaga gtctaagccc 1500 aaacaggaat tcctgttgaa tcttcattca gaggaaaata ttcaaaagcc attcagtgct 1560 ggttttaaga gaacctctac tttgactgtt caagaccaag aggagttgtg taatgggaaa 1620 tgcaagtcaa aacagctttg taggtctcag agtttgcttt taagaagtag tacaagaagg 1680 aatagttata tcaatacacc agtggctgaa attatcatga aaccaaatgt tggacaaggc 1740 agcacaagtg tgcaaacagc tatggaaagt gaactcggag agtctagtgc cacaatcaat 1800 aaaagactct gcaaaagtac aatagaactt tcagaaaatt ctttacttcc agcttcttct 1860 atgttgactg gcacacaaag cttgctgcaa cctcatttag agagggttgc catcgatgct 1920 ctacagttat gttgtttgtt acttccccca ccaaatcgta gaaagcttca acttttaatg 1980 cgtatgattt cccgaatgag tcaaaatgtt gatatgccca aacttcatga tgcaatgggt 2040 acgaggtcac tgatgataca taccttttct cgatgtgtgt tatgctgtgc tgaagaagtg 2100 gatcttgatg agcttcttgc tggaagatta gtttctttct taatggatca tcatcaggaa 2160 attcttcaag taccctctta cttacagact gcagtggaaa aacatcttga ctacttaaaa 2220 aagggacata ttgaaaatcc tggagatgga ctatttgctc ctttgccaac ttactcatac 2280 tgtaagcaga ttagtgctca ggagtttgat gagcaaaaag tttctacctc tcaagctgca 2340 attgcagaac ttttagaaaa tattattaaa aacaggagtt tacctctaaa ggagaaaaga 2400 aaaaaactaa aacagtttca gaaggaatat cctttgatat atcagaaaag atttccaacc 2460 acggagagtg aagcagcact ttttggtgac aaacctacaa tcaagcaacc aatgctgatt 2520 ttaagaaaac caaagttccg tagtctaaga taactaactg aattaaaaat tatgtaatac 2580 ttgtggaact ttgataaatg aagccatatc tgagaatgta gctactcaaa aggaagtctg 2640 tcattaataa ggtatttcta aataaacaca ttatgtaagg aagtgccaaa atagttatca 2700 atgtgagact cttaggaaac taactagatc tcaattgaga gcacataaca atagatgata 2760 ccaaatactt tttgttttta acacagctat ccagtaaggc tatcatgatg tgtgctaaaa 2820 ttttatttac ttgaattttg aaaactgagc tgtgttaggg attaaactat aattctgttc 2880 ttaaaagaaa atttatctgc aaatgtgcaa gttctgagat attagctaat gaattagttg 2940 tttggggtta cttctttgtt tctaagtata agaatgtgaa gaatatttga aaactcaatg 3000 aaataattct cagctgccaa atgttgcact cttttatata ttctttttcc acttttgatc 3060 tatttatata tatgtatgtg tttttaaaat atgtgtatat tttatcagat ttggttttgc 3120 cttaaatatt atccccaatt gcttcagtca ttcatttgtt cagtatatat attttgaatt 3180 ctagttttca taatctatta gaagatgggg atataaaaga agtataaggc aatcatatat 3240 tcattcaaaa gatatttatt tagcaactgc tatgtgcctt tcgttgttcc agatatgcag 3300 agacaatgat aaataaaaca tataatctct tccataaggt atttattttt taatcaaggg 3360 agatacacct atcagatgtt taaaataaca acactaccca ctgaaatcag ggcatataga 3420 atcattcagc taaagagtga cttctatgat gatggaacag gtctctaagc tagtggtttt 3480 caaactggta cacattagac tcacccgagg aattttaaaa cagcctatat gcccagggcc 3540 taacttacac taattaaatc tgaattttgg ggatgttgta tagggattag tatttttttt 3600 aatctaggtg attccaatat tcagccaact gtgagaatca atggcctaaa tgctttttat 3660 aaacattttt ataagtgtca agataatggc acattgactt tattttttca ttggaagaaa 3720 atgcctgcca agtataaatg actctcatct taaaacaagg ttcttcaggt ttctgcttga 3780 ttgacttggt acaaacttga agcaagttgc cttctaattt ttactccaag attgtttcat 3840 atctattcct taagtgtaaa gaaatatata atgcatggtt tgtaataaaa tcttaatgtt 3900 taatgactgt tctcatttct caatgtaatt tcatactgtt tctctataaa atgatagtat 3960 tccatttaac attactgatt tttattaaaa acctggacag aaaattataa attataaata 4020 tgactttatc ctggctataa aattattgaa ccaaaatgaa ttctttctaa ggcatttgaa 4080 tactaaaacg tttattgttt atagatatgt aaaatgtgga ttatgttgca aattgagatt 4140 aaaattattt ggggttttgt aacaatataa ttttgctttt gtattataga caaatatata 4200 aataataaag gcaggcaact ttcatttgca ctaatgtaca tgcaattgag attacaaaat 4260 acatggtaca atgctttaat aacaaactct gccagtcagg tttgaatcct actgtgctat 4320 taactagcta gtaaactcag acaagttact taacttctct aagccccagt tttgttatct 4380 ataaaatgaa tattataata gtacctcttt ttaggattgc gaggattaag caggataatg 4440 catgtaaagt gttagcacag tgtctcacat agaataagca ctctataaat attttactag 4500 aatcacctag gattatagca ctagaagaga tcttagcaaa aatgtggtcc tttctgttgc 4560 tttggacaga catgaaccaa aacaaaatta cggacaattg atgagcctta ttaactatct 4620 tttcattatg agacaaaggt tctgattatg cctactggtt gaaatttttt aatctagtca 4680 agaaggaaaa tttgatgagg aaggaaggaa tggatatctt cagaagggct tcgcctaagc 4740 tggaacatgg atagattcca ttctaacata aagatcttta agttcaaata tagatgagtt 4800 gactggtaga tttggtggta gttgctttct cgggatataa gaagcaaaat caactgctac 4860 aagtaaagag gggatgggga aggtgttgca catttaaaga gagaaagtgt gaaaaagcct 4920 aattgtggga atgcacaggt ttcaccagat cagatgatgt ctggttattc tgtaaattat 4980 agttcttatc ccagaaatta ctgcctccac catccctaat atcttctaat tggtatcata 5040 taatgaccca ctcttcttat gttatccaaa cagttatgtg gcatttagta atggaatgta 5100 catggaattt cccactgact tacctttctg tccttgggaa gcttaaactc tgaatcttct 5160 catctgtaaa atgtgaatta aagtatctac ctaactgagt tgtgattgta gtgaaagaaa 5220 ggcaatatat ttaaatcttg aatttagcaa gcccacgctt gatttttatg tcctttcctc 5280 ttgccttgta ttgagtttaa gatctctact gattaaaact cttttgctat caaaaaaaaa 5340 aaaaaaaaaa aaaaaa 5356 <210> 26 <211> 728 <212> DNA <213> Homo sapiens pituitary tumor-transforming 1 (PTTG1) <400> 26 gcggcctcag atgaatgcgg ctgttaagac ctgcaataat ccagaatggc tactctgatc 60 tatgttgata aggaaaatgg agaaccaggc acccgtgtgg ttgctaagga tgggctgaag 120 ctggggtctg gaccttcaat caaagcctta gatgggagat ctcaagtttc aacaccacgt 180 tttggcaaaa cgttcgatgc cccaccagcc ttacctaaag ctactagaaa ggctttggga 240 actgtcaaca gagctacaga aaagtctgta aagaccaagg gacccctcaa acaaaaacag 300 ccaagctttt ctgccaaaaa gatgactgag aagactgtta aagcaaaaag ctctgttcct 360 gcctcagatg atgcctatcc agaaatagaa aaattctttc ccttcaatcc tctagacttt 420 gagagttttg acctgcctga agagcaccag attgcgcacc tccccttgag tggagtgcct 480 ctcatgatcc ttgacgagga gagagagctt gaaaagctgt ttcagctggg ccccccttca 540 cctgtgaaga tgccctctcc accatgggaa tccaatctgt tgcagtctcc ttcaagcatt 600 ctgtcgaccc tggatgttga attgccacct gtttgctgtg acatagatat ttaaatttct 660 tagtgcttca gagtttgtgt gtatttgtat taataaagca ttcttcaaca gaaaaaaaaa 720 aaaaaaaa 728 <210> 27 <211> 3641 <212> DNA <213> Homo sapiens forkhead box M1 (FOXM1) <400> 27 actgaaagct ccggtgccag accccacccc cggccccggc ccgggacccc ctcccctccc 60 gggatccccc ggggttccca ccccgcccgc accgccgggg acccggccgg tccggcgcga 120 gcccccgtcc ggggccctgg ctcggccccc aggttggagg agcccggagc ccgccttcgg 180 agctacggcc taacggcggc ggcgactgca gtctggaggg tccacacttg tgattctcaa 240 tggagagtga aaacgcagat tcataatgaa aactagcccc cgtcggccac tgattctcaa 300 aagacggagg ctgccccttc ctgttcaaaa tgccccaagt gaaacatcag aggaggaacc 360 taagagatcc cctgcccaac aggagtctaa tcaagcagag gcctccaagg aagtggcaga 420 gtccaactct tgcaagtttc cagctgggat caagattatt aaccacccca ccatgcccaa 480 cacgcaagta gtggccatcc ccaacaatgc taatattcac agcatcatca cagcactgac 540 tgccaaggga aaagagagtg gcagtagtgg gcccaacaaa ttcatcctca tcagctgtgg 600 gggagcccca actcagcctc caggactccg gcctcaaacc caaaccagct atgatgccaa 660 aaggacagaa gtgaccctgg agaccttggg accaaaacct gcagctaggg atgtgaatct 720 tcctagacca cctggagccc tttgcgagca gaaacgggag acctgtgcag atggtgaggc 780 agcaggctgc actatcaaca atagcctatc caacatccag tggcttcgaa agatgagttc 840 tgatggactg ggctcccgca gcatcaagca agagatggag gaaaaggaga attgtcacct 900 ggagcagcga caggttaagg ttgaggagcc ttcgagacca tcagcgtcct ggcagaactc 960 tgtgtctgag cggccaccct actcttacat ggccatgata caattcgcca tcaacagcac 1020 tgagaggaag cgcatgactt tgaaagacat ctatacgtgg attgaggacc actttcccta 1080 ctttaagcac attgccaagc caggctggaa gaactccatc cgccacaacc tttccctgca 1140 cgacatgttt gtccgggaga cgtctgccaa tggcaaggtc tccttctgga ccattcaccc 1200 cagtgccaac cgctacttga cattggacca ggtgtttaag ccactggacc cagggtctcc 1260 acaattgccc gagcacttgg aatcacagca gaaacgaccg aatccagagc tccgccggaa 1320 catgaccatc aaaaccgaac tccccctggg cgcacggcgg aagatgaagc cactgctacc 1380 acgggtcagc tcatacctgg tacctatcca gttcccggtg aaccagtcac tggtgttgca 1440 gccctcggtg aaggtgccat tgcccctggc ggcttccctc atgagctcag agcttgcccg 1500 ccatagcaag cgagtccgca ttgcccccaa ggtttttggg gaacaggtgg tgtttggtta 1560 catgagtaag ttctttagtg gcgatctgcg agattttggt acacccatca ccagcttgtt 1620 taattttatc tttctttgtt tatcagtgct gctagctgag gaggggatag ctcctctttc 1680 ttctgcagga ccagggaaag aggagaaact cctgtttgga gaagggtttt ctcctttgct 1740 tccagttcag actatcaagg aggaagaaat ccagcctggg gaggaaatgc cacacttagc 1800 gagacccatc aaagtggaga gccctccctt ggaagagtgg ccctccccgg ccccatcttt 1860 caaagaggaa tcatctcact cctgggagga ttcgtcccaa tctcccaccc caagacccaa 1920 gaagtcctac agtgggctta ggtccccaac ccggtgtgtc tcggaaatgc ttgtgattca 1980 acacagggag aggagggaga ggagccggtc tcggaggaaa cagcatctac tgcctccctg 2040 tgtggatgag ccggagctgc tcttctcaga ggggcccagt acttcccgct gggccgcaga 2100 gctcccgttc ccagcagact cctctgaccc tgcctcccag ctcagctact cccaggaagt 2160 gggaggacct tttaagacac ccattaagga aacgctgccc atctcctcca ccccgagcaa 2220 atctgtcctc cccagaaccc ctgaatcctg gaggctcacg cccccagcca aagtaggggg 2280 actggatttc agcccagtac aaacctccca gggtgcctct gaccccttgc ctgaccccct 2340 ggggctgatg gatctcagca ccactccctt gcaaagtgct cccccccttg aatcaccgca 2400 aaggctcctc agttcagaac ccttagacct catctccgtc ccctttggca actcttctcc 2460 ctcagatata gacgtcccca agccaggctc cccggagcca caggtttctg gccttgcagc 2520 caatcgttct ctgacagaag gcctggtcct ggacacaatg aatgacagcc tcagcaagat 2580 cctgctggac atcagctttc ctggcctgga cgaggaccca ctgggccctg acaacatcaa 2640 ctggtcccag tttattcctg agctacagta gagccctgcc cttgcccctg tgctcaagct 2700 gtccaccatc ccgggcactc caaggctcag tgcaccccaa gcctctgagt gaggacagca 2760 ggcagggact gttctgctcc tcatagctcc ctgctgcctg attatgcaaa agtagcagtc 2820 acaccctagc cactgctggg accttgtgtt ccccaagagt atctgattcc tctgctgtcc 2880 ctgccaggag ctgaagggtg ggaacaacaa aggcaatggt gaaaagagat taggaacccc 2940 ccagcctgtt tccattctct gcccagcagt ctcttacctt ccctgatctt tgcagggtgg 3000 tccgtgtaaa tagtataaat tctccaaatt atcctctaat tataaatgta agcttatttc 3060 cttagatcat tatccagaga ctgccagaag gtgggtagga tgacctgggg tttcaattga 3120 cttctgttcc ttgcttttag ttttgataga agggaagacc tgcagtgcac ggtttcttcc 3180 aggctgaggt acctggatct tgggttcttc actgcaggga cccagacaag tggatctgct 3240 tgccagagtc ctttttgccc ctccctgcca cctccccgtg tttccaagtc agctttcctg 3300 caagaagaaa tcctggttaa aaaagtcttt tgtattgggt caggagttga atttggggtg 3360 ggaggatgga tgcaactgaa gcagagtgtg ggtgcccaga tgtgcgctat tagatgtttc 3420 tctgataatg tccccaatca taccagggag actggcattg acgagaactc aggtggaggc 3480 ttgagaaggc cgaaagggcc cctgacctgc ctggcttcct tagcttgccc ctcagctttg 3540 caaagagcca ccctaggccc cagctgaccg catgggtgtg agccagcttg agaacactaa 3600 ctactcaata aaagcgaagg tggacaaaaa aaaaaaaaaa a 3641 <210> 28 <211> 2896 <212> DNA <213> Homo sapiens kinesin family member 2C (KIF2C) <400> 28 acgcttgcgc gcgggattta aactgcggcg gtttacgcgg cgttaagact tcgtagggtt 60 agcgaaattg aggtttcttg gtattgcgcg tttctcttcc ttgctgactc tccgaatggc 120 catggactcg tcgcttcagg cccgcctgtt tcccggtctc gctatcaaga tccaacgcag 180 taatggttta attcacagtg ccaatgtaag gactgtgaac ttggagaaat cctgtgtttc 240 agtggaatgg gcagaaggag gtgccacaaa gggcaaagag attgattttg atgatgtggc 300 tgcaataaac ccagaactct tacagcttct tcccttacat ccgaaggaca atctgccctt 360 gcaggaaaat gtaacaatcc agaaacaaaa acggagatcc gtcaactcca aaattcctgc 420 tccaaaagaa agtcttcgaa gccgctccac tcgcatgtcc actgtctcag agcttcgcat 480 cacggctcag gagaatgaca tggaggtgga gctgcctgca gctgcaaact cccgcaagca 540 gttttcagtt cctcctgccc ccactaggcc ttcctgccct gcagtggctg aaataccatt 600 gaggatggtc agcgaggaga tggaagagca agtccattcc atccgaggca gctcttctgc 660 aaaccctgtg aactcagttc ggaggaaatc atgtcttgtg aaggaagtgg aaaaaatgaa 720 gaacaagcga gaagagaaga aggcccagaa ctctgaaatg agaatgaaga gagctcagga 780 gtatgacagt agttttccaa actgggaatt tgcccgaatg attaaagaat ttcgggctac 840 tttggaatgt catccactta ctatgactga tcctatcgaa gagcacagaa tatgtgtctg 900 tgttaggaaa cgcccactga ataagcaaga attggccaag aaagaaattg atgtgatttc 960 cattcctagc aagtgtctcc tcttggtaca tgaacccaag ttgaaagtgg acttaacaaa 1020 gtatctggag aaccaagcat tctgctttga ctttgcattt gatgaaacag cttcgaatga 1080 agttgtctac aggttcacag caaggccact ggtacagaca atctttgaag gtggaaaagc 1140 aacttgtttt gcatatggcc agacaggaag tggcaagaca catactatgg gcggagacct 1200 ctctgggaaa gcccagaatg catccaaagg gatctatgcc atggcctccc gggacgtctt 1260 cctcctgaag aatcaaccct gctaccggaa gttgggcctg gaagtctatg tgacattctt 1320 cgagatctac aatgggaagc tgtttgacct gctcaacaag aaggccaagc tgcgcgtgct 1380 ggaggacggc aagcaacagg tgcaagtggt ggggctgcag gagcatctgg ttaactctgc 1440 tgatgatgtc atcaagatga tcgacatggg cagcgcctgc agaacctctg ggcagacatt 1500 tgccaactcc aattcctccc gctcccacgc gtgcttccaa attattcttc gagctaaagg 1560 gagaatgcat ggcaagttct ctttggtaga tctggcaggg aatgagcgag gcgcggacac 1620 ttccagtgct gaccggcaga cccgcatgga gggcgcagaa atcaacaaga gtctcttagc 1680 cctgaaggag tgcatcaggg ccctgggaca gaacaaggct cacaccccgt tccgtgagag 1740 caagctgaca caggtgctga gggactcctt cattggggag aactctagga cttgcatgat 1800 tgccacgatc tcaccaggca taagctcctg tgaatatact ttaaacaccc tgagatatgc 1860 agacagggtc aaggagctga gcccccacag tgggcccagt ggagagcagt tgattcaaat 1920 ggaaacagaa gagatggaag cctgctctaa cggggcgctg attccaggca atttatccaa 1980 ggaagaggag gaactgtctt cccagatgtc cagctttaac gaagccatga ctcagatcag 2040 ggagctggag gagaaggcta tggaagagct caaggagatc atacagcaag gaccagactg 2100 gcttgagctc tctgagatga ccgagcagcc agactatgac ctggagacct ttgtgaacaa 2160 agcggaatct gctctggccc agcaagccaa gcatttctca gccctgcgag atgtcatcaa 2220 ggccttgcgc ctggccatgc agctggaaga gcaggctagc agacaaataa gcagcaagaa 2280 acggccccag tgacgactgc aaataaaaat ctgtttggtt tgacacccag cctcttccct 2340 ggccctcccc agagaacttt gggtacctgg tgggtctagg cagggtctga gctgggacag 2400 gttctggtaa atgccaagta tgggggcatc tgggcccagg gcagctgggg agggggtcag 2460 agtgacatgg gacactcctt ttctgttcct cagttgtcgc cctcacgaga ggaaggagct 2520 cttagttacc cttttgtgtt gcccttcttt ccatcaaggg gaatgttctc agcatagagc 2580 tttctccgca gcatcctgcc tgcgtggact ggctgctaat ggagagctcc ctggggttgt 2640 cctggctctg gggagagaga cggagccttt agtacagcta tctgctggct ctaaaccttc 2700 tacgcctttg ggccgagcac tgaatgtctt gtactttaaa aaaatgtttc tgagacctct 2760 ttctacttta ctgtctccct agagatccta gaggatccct actgttttct gttttatgtg 2820 tttatacatt gtatgtaaca ataaagagaa aaaataaatc agctgtttaa gtgtgtggaa 2880 aaaaaaaaaa aaaaaa 2896 <210> 29 <211> 3010 <212> DNA <213> Homo sapiens TTK protein kinase (TTK), transcript variant 1 <400> 29 agcattgacc aataggagac cgtagtgata gcgacgggga aattcaaacg tgtttgcgga 60 aaggagtttg ggttccatct tttcatttcc ccagcgcagc tttctgtaga aatggaatcc 120 gaggatttaa gtggcagaga attgacaatt gattccataa tgaacaaagt gagagacatt 180 aaaaataagt ttaaaaatga agaccttact gatgaactaa gcttgaataa aatttctgct 240 gatactacag ataactcggg aactgttaac caaattatga tgatggcaaa caacccagag 300 gactggttga gtttgttgct caaactagag aaaaacagtg ttccgctaag tgatgctctt 360 ttaaataaat tgattggtcg ttacagtcaa gcaattgaag cgcttccccc agataaatat 420 ggccaaaatg agagttttgc tagaattcaa gtgagatttg ctgaattaaa agctattcaa 480 gagccagatg atgcacgtga ctactttcaa atggccagag caaactgcaa gaaatttgct 540 tttgttcata tatcttttgc acaatttgaa ctgtcacaag gtaatgtcaa aaaaagtaaa 600 caacttcttc aaaaagctgt agaacgtgga gcagtaccac tagaaatgct ggaaattgcc 660 ctgcggaatt taaacctcca aaaaaagcag ctgctttcag aggaggaaaa gaagaattta 720 tcagcatcta cggtattaac tgcccaagaa tcattttccg gttcacttgg gcatttacag 780 aataggaaca acagttgtga ttccagagga cagactacta aagccaggtt tttatatgga 840 gagaacatgc caccacaaga tgcagaaata ggttaccgga attcattgag acaaactaac 900 aaaactaaac agtcatgccc atttggaaga gtcccagtta accttctaaa tagcccagat 960 tgtgatgtga agacagatga ttcagttgta ccttgtttta tgaaaagaca aacctctaga 1020 tcagaatgcc gagatttggt tgtgcctgga tctaaaccaa gtggaaatga ttcctgtgaa 1080 ttaagaaatt taaagtctgt tcaaaatagt catttcaagg aacctctggt gtcagatgaa 1140 aagagttctg aacttattat tactgattca ataaccctga agaataaaac ggaatcaagt 1200 cttctagcta aattagaaga aactaaagag tatcaagaac cagaggttcc agagagtaac 1260 cagaaacagt ggcaatctaa gagaaagtca gagtgtatta accagaatcc tgctgcatct 1320 tcaaatcact ggcagattcc ggagttagcc cgaaaagtta atacagagca gaaacatacc 1380 acttttgagc aacctgtctt ttcagtttca aaacagtcac caccaatatc aacatctaaa 1440 tggtttgacc caaaatctat ttgtaagaca ccaagcagca ataccttgga tgattacatg 1500 agctgtttta gaactccagt tgtaaagaat gactttccac ctgcttgtca gttgtcaaca 1560 ccttatggcc aacctgcctg tttccagcag caacagcatc aaatacttgc cactccactt 1620 caaaatttac aggttttagc atcttcttca gcaaatgaat gcatttcggt taaaggaaga 1680 atttattcca tattaaagca gataggaagt ggaggttcaa gcaaggtatt tcaggtgtta 1740 aatgaaaaga aacagatata tgctataaaa tatgtgaact tagaagaagc agataaccaa 1800 actcttgata gttaccggaa cgaaatagct tatttgaata aactacaaca acacagtgat 1860 aagatcatcc gactttatga ttatgaaatc acggaccagt acatctacat ggtaatggag 1920 tgtggaaata ttgatcttaa tagttggctt aaaaagaaaa aatccattga tccatgggaa 1980 cgcaagagtt actggaaaaa tatgttagag gcagttcaca caatccatca acatggcatt 2040 gttcacagtg atcttaaacc agctaacttt ctgatagttg atggaatgct aaagctaatt 2100 gattttggga ttgcaaacca aatgcaacca gatacaacaa gtgttgttaa agattctcag 2160 gttggcacag ttaattatat gccaccagaa gcaatcaaag atatgtcttc ctccagagag 2220 aatgggaaat ctaagtcaaa gataagcccc aaaagtgatg tttggtcctt aggatgtatt 2280 ttgtactata tgacttacgg gaaaacacca tttcagcaga taattaatca gatttctaaa 2340 ttacatgcca taattgatcc taatcatgaa attgaatttc ccgatattcc agagaaagat 2400 cttcaagatg tgttaaagtg ttgtttaaaa agggacccaa aacagaggat atccattcct 2460 gagctcctgg ctcatccata tgttcaaatt caaactcatc cagttaacca aatggccaag 2520 ggaaccactg aagaaatgaa atatgttctg ggccaacttg ttggtctgaa ttctcctaac 2580 tccattttga aagctgctaa aactttatat gaacactata gtggtggtga aagtcataat 2640 tcttcatcct ccaagacttt tgaaaaaaaa aggggaaaaa aatgatttgc agttattcgt 2700 aatgtcagat accacctata aaatatattg gactgttata ctcttgaatc cctgtggaaa 2760 tctacatttg aagacaacat cactctgaag tgttatcagc aaaaaaaatt cagtagatta 2820 tctttaaaag aaaactgtaa aaatagcaac cacttatggc actgtatata ttgtagactt 2880 gttttctctg ttttatgctc ttgtgtaatc tacttgacat cattttactc ttggaatagt 2940 gggtggatag caagtatatt ctaaaaaact ttgtaaataa agttttgtgg ctaaaatgac 3000 actaacattt 3010 <210> 30 <211> 3284 <212> DNA <213> Homo sapiens ribonucleotide reductase M2 (RRM2) <400> 30 cccgtgcacc ctgtcccagc cgtcctgtcc tggctgctcg ctctgcttcg ctgcgcctcc 60 actatgctct ccctccgtgt cccgctcgcg cccatcacgg acccgcagca gctgcagctc 120 tcgccgctga aggggctcag cttggtcgac aaggagaaca cgccgccggc cctgagcggg 180 acccgcgtcc tggccagcaa gaccgcgagg aggatcttcc aggagcccac ggagccgaaa 240 actaaagcag ctgcccccgg cgtggaggat gagccgctgc tgagagaaaa cccccgccgc 300 tttgtcatct tccccatcga gtaccatgat atctggcaga tgtataagaa ggcagaggct 360 tccttttgga ccgccgagga ggtggacctc tccaaggaca ttcagcactg ggaatccctg 420 aaacccgagg agagatattt tatatcccat gttctggctt tctttgcagc aagcgatggc 480 atagtaaatg aaaacttggt ggagcgattt agccaagaag ttcagattac agaagcccgc 540 tgtttctatg gcttccaaat tgccatggaa aacatacatt ctgaaatgta tagtcttctt 600 attgacactt acataaaaga tcccaaagaa agggaatttc tcttcaatgc cattgaaacg 660 atgccttgtg tcaagaagaa ggcagactgg gccttgcgct ggattgggga caaagaggct 720 acctatggtg aacgtgttgt agcctttgct gcagtggaag gcattttctt ttccggttct 780 tttgcgtcga tattctggct caagaaacga ggactgatgc ctggcctcac attttctaat 840 gaacttatta gcagagatga gggtttacac tgtgattttg cttgcctgat gttcaaacac 900 ctggtacaca aaccatcgga ggagagagta agagaaataa ttatcaatgc tgttcggata 960 gaacaggagt tcctcactga ggccttgcct gtgaagctca ttgggatgaa ttgcactcta 1020 atgaagcaat acattgagtt tgtggcagac agacttatgc tggaactggg ttttagcaag 1080 gttttcagag tagagaaccc atttgacttt atggagaata tttcactgga aggaaagact 1140 aacttctttg agaagagagt aggcgagtat cagaggatgg gagtgatgtc aagtccaaca 1200 gagaattctt ttaccttgga tgctgacttc taaatgaact gaagatgtgc ccttacttgg 1260 ctgatttttt ttttccatct cataagaaaa atcagctgaa gtgttaccaa ctagccacac 1320 catgaattgt ccgtaatgtt cattaacagc atctttaaaa ctgtgtagct acctcacaac 1380 cagtcctgtc tgtttatagt gctggtagta tcaccttttg ccagaaggcc tggctggctg 1440 tgacttacca tagcagtgac aatggcagtc ttggctttaa agtgaggggt gaccctttag 1500 tgagcttagc acagcgggat taaacagtcc tttaaccagc acagccagtt aaaagatgca 1560 gcctcactgc ttcaacgcag attttaatgt ttacttaaat ataaacctgg cactttacaa 1620 acaaataaac attgtttgta ctcacaaggc gataatagct tgatttattt ggtttctaca 1680 ccaaatacat tctcctgacc actaatggga gccaattcac aattcactaa gtgactaaag 1740 taagttaaac ttgtgtagac taagcatgta atttttaagt tttattttaa tgaattaaaa 1800 tatttgttaa ccaactttaa agtcagtcct gtgtatacct agatattagt cagttggtgc 1860 cagatagaag acaggttgtg tttttatcct gtggcttgtg tagtgtcctg ggattctctg 1920 ccccctctga gtagagtgtt gtgggataaa ggaatctctc agggcaagga gcttcttaag 1980 ttaaatcact agaaatttag gggtgatctg ggccttcata tgtgtgagaa gccgtttcat 2040 tttatttctc actgtatttt cctcaacgtc tggttgatga gaaaaaattc ttgaagagtt 2100 ttcatatgtg ggagctaagg tagtattgta aaatttcaag tcatccttaa acaaaatgat 2160 ccacctaaga tcttgcccct gttaagtggt gaaatcaact agaggtggtt cctacaagtt 2220 gttcattcta gttttgtttg gtgtaagtag gttgtgtgag ttaattcatt tatatttact 2280 atgtctgtta aatcagaaat tttttattat ctatgttctt ctagatttta cctgtagttc 2340 atacttcagt cacccagtgt cttattctgg cattgtctaa atctgagcat tgtctagggg 2400 gatcttaaac tttagtagga aaccatgagc tgttaataca gtttccattc aaatattaat 2460 ttcagaatga aacataattt tttttttttt ttttgagatg gagtctcgct ctgttgccca 2520 ggctggagtg cagtggcgcg attttggctc actgtaacct ccatctcctg ggttcaagca 2580 attctcctgt ctcagcctcc ctagtagctg ggactgcagg tatgtgctac cacacctggc 2640 taatttttgt atttttagta gagatggagt ttcaccatat tggtcaggct ggtcttgaac 2700 tcctgacctc aggtgatcca cccacctcgg cctcccaaag tgctgggatt gcaggcgtga 2760 taaacaaata ttcttaatag ggctactttg aattaatctg cctttatgtt tgggagaaga 2820 aagctgagac attgcatgaa agatgatgag agataaatgt tgatcttttg gccccatttg 2880 ttaattgtat tcagtatttg aacgtcgtcc tgtttattgt tagttttctt catcatttat 2940 tgtatagaca atttttaaat ctctgtaata tgatacattt tcctatcttt taagttattg 3000 ttacctaaag ttaatccaga ttatatggtc cttatatgtg tacaacatta aaatgaaagg 3060 ctttgtcttg cattgtgagg tacaggcgga agttggaatc aggttttagg attctgtctc 3120 tcattagctg aataatgtga ggattaactt ctgccagctc agaccatttc ctaatcagtt 3180 gaaagggaaa caagtatttc agtctcaaaa ttgaataatg cacaagtctt aagtgattaa 3240 aataaaactg ttcttatgtc agtttcaaaa aaaaaaaaaa aaaa 3284 <210> 31 <211> 3128 <212> DNA <213> Homo sapiens G-2 and S-phase expressed 1 (GTSE1) <400> 31 attcgctgcg ctgaagcagt gcgcatgcgc actggacgct tcttaccagc gtcctgacta 60 caatacccag gacgcaccca gcccgccgcc tctcggagcc cttttcaaac cgaccaatcg 120 gcaacccgcg tctcccggcg ccgcgtttaa atccgtgccg gaggcgcgtc ctgcatcgtc 180 tgccgctttg gtgacttctg acagctctct ccatggaagg aggcggcggc cgcgatgagc 240 cttcagcctg ccgggcaggg gacgtgaaca tggatgaccc taagaaggaa gacattcttc 300 ttttggccga tgaaaaattt gacttcgatc tttcattgtc ttcttcgagt gcaaatgaag 360 atgatgaagt cttcttcgga ccctttggac ataaagaaag atgtattgct gccagcttgg 420 aattaaataa tccggttccc gaacagcctc cgttgcccac atctgagagt ccctttgcct 480 ggagccctct ggccggggag aagttcgtgg aggtgtacaa agaagctcac ttactggctt 540 tacacattga gagcagcagc cggaaccagg cagcccaagc tgccaagcct gaagaccctc 600 ggagccaggg cgtggaaaga ttcatacagg agtcaaaatt aaaaataaac ctctttgaga 660 aagaaaagga aatgaagaaa agccccacgt ctcttaaaag ggagacatac tacctgtcag 720 acagcccctt gctggggccc cctgtgggtg agcctcggct cttggcctcc tccccggccc 780 tgcccagctc tggtgcccag gcccgcctca cccgggcgcc ggggcctccg cactctgctc 840 atgctttgcc cagggaatca tgcactgctc atgctgcaag tcaggcagcg actcagagga 900 agcccgggac caaattgctg ctgcctcgag cggcctctgt tagaggaaga agcatccctg 960 gggctgcgga gaagcccaag aaagagattc cagctagtcc ttccaggaca aaaatcccag 1020 ctgagaagga atcccaccgg gatgttctcc ctgacaaacc tgccccgggt gctgtcaatg 1080 tgccggccgc cggaagccac ttgggccagg gcaagcgggc gatccctgtt ccaaacaagt 1140 tggggctgaa gaagaccctg ttaaaagcac ccggctctac cagcaatctc gcaaggaagt 1200 cctcctcggg gcctgtttgg agcggggcat ccagtgcgtg cacatcccca gcagtgggca 1260 aagctaaatc aagtgaattt gcaagtattc ctgcaaatag ctcccggcct ctgtcaaaca 1320 tcagcaagtc aggcagaatg ggacccgcca tgctgcggcc agctctgcct gcaggccctg 1380 tgggggcatc ctcctggcag gccaagcggg tcgatgtttc tgagctggca gcggagcagc 1440 tcacggcacc cccctcagca tcccccaccc aaccccagac tccggaaggt ggcggccagt 1500 ggctgaactc cagttgcgct tggtcagaat cttctcaatt gaataagact agaagtatca 1560 gacggcgaga ttcctgtcta aattccaaga caaaggttat gcctactcct acaaatcaat 1620 ttaaaattcc taagttttct attggtgact ccccggacag ctcaacacca aagctttcgc 1680 gggcacagcg gccgcagtcg tgcacgtcag ttggcagggt cactgtccac agcaccccgg 1740 ttagacgctc atctgggcca gcaccacaaa gcctgctgag cgcacggcgt gtgtcagcct 1800 tgcccacacc cgccagccgg cgctgctctg gccttccacc gatgaccccc aaaacgatgc 1860 ccagggccgt gggctctccc ctgtgtgtgc cagctcggag acgttcctct gagccccgca 1920 agaactctgc aatgagaact gaaccaacaa gggagagcaa cagaaagaca gattccaggc 1980 tggtggatgt gtcccctgac aggggttctc ctccttcccg tgtgcctcag gcacttaact 2040 tttctccaga ggaaagcgat tctactttct ccaaaagtac tgccacagaa gtagctcggg 2100 aggaagccaa gccgggtgga gatgcagccc ctagtgaggc tcttcttgta gatatcaaac 2160 tggaaccact cgcggtcact ccagatgctg caagccagcc cctcattgac cttcctctca 2220 tcgacttctg cgatacccca gaagcacacg tggctgtagg atctgaaagc aggcctctga 2280 tcgacctcat gacaaacact ccagacatga ataaaaatgt ggccaaacct tcaccggtgg 2340 tgggacagct catagacctg agctcccctc tgatccagct gagccctgag gctgacaagg 2400 agaacgtgga ttccccactc ctcaagttct aagccgaacc aaatcctttg ccttgaaaga 2460 acagccctaa agtggttttc aaccctcaga aacaagcttt aggctggtcg cagtggctta 2520 cacttgtaac cctagaactt gggaggctga ggtgggcgga ttacttgagc ccaggagttc 2580 gggaccagcc tgggaaatat agtgaaactc ctgtccctac aaaaaataca aaaattagcc 2640 gggtgtggta gtgcatgcct gtagtcccag ctacttggga ggctgaagtg ggaggatggc 2700 ctgagctcaa ggagatgcag gctgcagtgg gctgtgattg tgccactgca ctccagcctg 2760 ggcaccaatg tgagaacctg tcttggaaaa aaaaaaaaag aaacatgttt tagtagaagt 2820 tttatttgaa aaagaaaaat aagcataaat atattcccag tgctggagag ggtgggctga 2880 gggactgggg ccagcacgga ccacccaagg cctctgcttc ccgccgccac cctcctcgct 2940 gccattctct gggctggaat gtgaagcctc agtcactcta aatgaagaat tttcttttga 3000 atgttttgta tgtaaaatag caagtggcta tttttaaagt taagtttgta taaatagtta 3060 gatattctag atttacatta aattgtaaaa taaatggact tattgaagca taaaaaaaaa 3120 aaaaaaaa 3128 <210> 32 <211> 6069 <212> DNA <213> Homo sapiens IQ motif containing GTPase activating protein 3 (IQGAP3) <400> 32 gtcctgtctg gcggtgccga cggtgagggg cggtggccca acggcgggag attcaaacct 60 ggaagaagga ggaacatgga gaggagagca gcgggcccag gctgggcagc ctatgaacgc 120 ctcacagctg aggagatgga tgagcagagg cggcagaatg ttgcctatca gtacctgtgc 180 cggctggagg aggccaagcg ctggatggag gcctgcctga aggaggagct tccttccccg 240 gtggagctgg aggagagcct tcggaatgga gtgctgctgg ccaagctagg ccactgtttt 300 gcaccctccg tggttccctt gaagaagatc tacgatgtgg agcagctgcg gtaccaggca 360 actggcttac atttccgtca cacagacaac atcaactttt ggctatctgc aatagcccac 420 atcggtctgc cttcgacctt cttcccagag accacggaca tctatgacaa aaagaacatg 480 ccccgggtag tctactgcat ccatgctctc agtctcttcc tcttccggct gggattggcc 540 cctcagatac atgatctata cgggaaagtg aaattcacag ctgaggaact cagcaacatg 600 gcgtccgaac tggccaaata tggcctccag ctgcctgcct tcagcaagat cgggggcatc 660 ttggccaatg agctctcggt ggatgaggct gcagtccatg cagctgttct tgccatcaat 720 gaagcagtgg agcgaggggt ggtggaggac accctggctg ccttgcagaa tcccagtgct 780 cttctggaga atctccgaga gcctctggca gccgtctacc aagagatgct ggcccaggcc 840 aagatggaga aggcagccaa tgccaggaac catgatgaca gagaaagcca ggacatctat 900 gaccactacc taactcaggc tgaaatccag ggcaatatca accatgtcaa cgtccatggg 960 gctctagaag ttgttgatga tgccctggaa agacagagcc ctgaagcctt gctcaaggcc 1020 cttcaagacc ctgccctggc cctgcgaggg gtgaggagag actttgctga ctggtacctg 1080 gagcagctga actcagacag agagcagaag gcacaggagc tgggcctggt ggagcttctg 1140 gaaaaggagg aagtccaggc tggtgtggct gcagccaaca caaagggtga tcaggaacaa 1200 gccatgctcc acgctgtgca gcggatcaac aaagccatcc ggaggggagt ggcggctgac 1260 actgtgaagg agctgatgtg ccctgaggcc cagctgcctc cagtgtaccc tgttgcatcg 1320 tctatgtacc agctggagct ggcagtgctc cagcagcagc agggggagct tggccaggag 1380 gagctcttcg tggctgtgga gatgctctca gctgtggtcc tgattaaccg ggccctggag 1440 gcccgggatg ccagtggctt ctggagcagc ctggtgaacc ctgccacagg cctggctgag 1500 gtggaaggag aaaatgccca gcgttacttc gatgccctgc tgaaattgcg acaggagcgt 1560 gggatgggtg aggacttcct gagctggaat gacctgcagg ccaccgtgag ccaggtcaat 1620 gcacagaccc aggaagagac tgaccgggtc cttgcagtca gcctcatcaa tgaggctctg 1680 gacaaaggca gccctgagaa gactctgtct gccctactgc ttcctgcagc tggcctagat 1740 gatgtcagcc tccctgtcgc ccctcggtac catctcctcc ttgtggcagc caaaaggcag 1800 aaggcccagg tgacagggga tcctggagct gtgctgtggc ttgaggagat ccgccaggga 1860 gtggtcagag ccaaccagga cactaataca gctcagagaa tggctcttgg tgtggctgcc 1920 atcaatcaag ccatcaagga gggcaaggca gcccagactg agcgggtgtt gaggaacccc 1980 gcagtggccc ttcgaggggt agttcccgac tgtgccaacg gctaccagcg agccctggaa 2040 agtgccatgg caaagaaaca gcgtccagca gacacagctt tctgggttca acatgacatg 2100 aaggatggca ctgcctacta cttccatctg cagaccttcc aggggatctg ggagcaacct 2160 cctggctgcc ccctcaacac ctctcacctg acccgggagg agatccagtc agctgtcacc 2220 aaggtcactg ctgcctatga ccgccaacag ctctggaaag ccaacgtcgg ctttgttatc 2280 cagctccagg cccgcctccg tggcttccta gttcggcaga agtttgctga gcattcccac 2340 tttctgagga cctggctccc agcagtcatc aagatccagg ctcattggcg gggttatagg 2400 cagcggaaga tttacctgga gtggttgcag tattttaaag caaacctgga tgccataatc 2460 aagatccagg cctgggcccg gatgtgggca gctcggaggc aatacctgag gcgtctgcac 2520 tacttccaga agaatgttaa ctccattgtg aagatccagg catttttccg agccaggaaa 2580 gcccaagatg actacaggat attagtgcat gcaccccacc ctcctctcag tgtggtacgc 2640 agatttgccc atctcttgaa tcaaagccag caagacttct tggctgaggc agagctgctg 2700 aagctccagg aagaggtagt taggaagatc cgatccaatc agcagctgga gcaggacctc 2760 aacatcatgg acatcaagat tggcctgctg gtgaagaacc ggatcactct gcaggaagtg 2820 gtctcccact gcaagaagct gaccaagagg aataaggaac agctgtcaga tatgatggtt 2880 ctggacaagc agaagggttt aaagtcgctg agcaaagaga aacggcagaa actagaagca 2940 taccaacacc tcttctacct gctccagact cagcccatct acctggccaa gctgatcttt 3000 cagatgccac agaacaaaac caccaagttc atggaggcag tgattttcag cctgtacaac 3060 tatgcctcca gccgccgaga ggcctatctc ctgctccagc tgttcaagac agcactccag 3120 gaggaaatca agtcaaaggt ggagcagccc caggacgtgg tgacaggcaa cccaacagtg 3180 gtgaggctgg tggtgagatt ctaccgtaat gggcggggac agagtgccct gcaggagatt 3240 ctgggcaagg ttatccagga tgtgctagaa gacaaagtgc tcagcgtcca cacagaccct 3300 gtccacctct ataagaactg gatcaaccag actgaggccc agacagggca gcgcagccat 3360 ctcccatatg atgtcacccc ggagcaggcc ttgagccacc ccgaggtcca gagacgactg 3420 gacatcgccc tacgcaacct cctcgccatg actgataagt tccttttagc catcacctca 3480 tctgtggacc aaattccgta tgggatgcga tatgtggcca aagtcctgaa ggcaactctg 3540 gcagagaaat tccctgacgc cacagacagc gaggtctata aggtggtcgg gaacctcctg 3600 tactaccgct tcctgaaccc agctgtggtg gctcctgacg ccttcgacat tgtggccatg 3660 gcagctggtg gagccctggc tgccccccag cgccatgccc tgggggctgt ggctcagctc 3720 ctacagcacg ctgcggctgg caaggccttc tctgggcaga gccagcacct acgggtcctg 3780 aatgactatc tggaggaaac acacctcaag ttcaggaagt tcatccatag agcctgccag 3840 gtgccagagc cagaggagcg ttttgcagtg gacgagtact cagacatggt ggctgtggcc 3900 aaacccatgg tgtacatcac cgtgggggag ctggtcaaca cgcacaggct gttgctggag 3960 caccaggact gcattgcccc tgatcaccaa gaccccctgc atgagctcct ggaggatctt 4020 ggggagctgc ccaccatccc tgaccttatt ggtgagagca tcgctgcaga tgggcacacg 4080 gacctgagca agctagaagt gtccctgacg ctgaccaaca agtttgaagg actagaggca 4140 gatgctgatg actccaacac ccgtagcctg cttctgagca ccaagcagct gttggccgat 4200 atcatacagt tccatcctgg ggacaccctc aaggagatcc tgtccctctc ggcttccaga 4260 gagcaagaag cagcccacaa gcagctgatg agccgacgcc aggcctgtac agcccagaca 4320 ccggagccac tgcgacgaca ccgctcactg acagctcact ccctcctgcc actggcagag 4380 aagcagcggc gcgtcctgcg gaacctacgc cgacttgaag ccctggggtt ggtcagcgcc 4440 agaaatggct accaggggct agtggacgag ctggccaagg acatccgcaa ccagcacaga 4500 cacaggcaca ggcggaaggc agagctggtg aagctgcagg ccacattaca gggcctgagc 4560 actaagacca ccttctatga ggagcagggt gactactaca gccagtacat ccgggcctgc 4620 ctggaccacc tggcccccga ctccaagagt tctgggaagg ggaagaagca gccttctctt 4680 cattacactg ctgctcagct cctggaaaag ggtgtcttgg tggaaattga agatcttccc 4740 gcctctcact tcagaaacgt catctttgac atcacgccgg gagatgaggc aggaaagttt 4800 gaagtaaatg ccaagttcct gggtgtggac atggagcgat ttcagcttca ctatcaggat 4860 ctcctgcagc tccagtatga gggtgtggct gtcatgaaac tcttcaacaa ggccaaagtc 4920 aatgtcaacc ttctcatctt cctcctcaac aagaagtttt tgcggaagtg acagaggcaa 4980 agggtgctac ccaagcccct cttacctctc tggatgcttt ctttaacact aactcaccac 5040 tgtgcttccc tgcagacacc cagagctcag gactgggcaa ggcccaggga ttctcacccc 5100 ttccccagct gggaggagct tgcctgcctg gccacagaca gtgtatcttc taattggcta 5160 aagtgggcct tgcccagagt ccagctgtgt ggcttttatc atgcatgaca aacccctggc 5220 tttcctgcca gatggtagga catggacctt gacctgggaa agccattact cttgtgtctg 5280 ctactgccct cccacagtca ccccaatatt acaagcactg ccccagcggc ttgatttccc 5340 ctctgccttc cttctctctg cactcccaca aagccagggc caggctcccc atccctacct 5400 cccactgcat cagcagtggg tgttcctgcc cttcctgagt ctaggcagct ctgctgctgt 5460 gatctgcaca ccctccaacc tgggcaggga ctggggggat gcagtgtgtg ttagtgccca 5520 tgtggcattg tggcactgtt gccccccatg gcggcatggg caagatgacc ttccattagc 5580 ttcaagtctt gttctcttgt ctgtggtctg tttaatatgt gggtcactag ggtatttatt 5640 ctttctccca tccttacact ctggatcatt gtgcagactt aatcagggtt ttaacgcttt 5700 catttttttt tttttttttt tttttttgag ctcaaagaga gttctcattt tccctattca 5760 aactaatacc catgccgtgt tttttacctt ggatttaaag tcaccttagg ttggggcaac 5820 agattctcac tcatgtttaa gatcttgtta tttcagcttc ataagatcaa agaggagtct 5880 ttcccttttc tcttttaccc tcaggattct catcccttac agctgactct tccaggcaat 5940 ttccatagat ctgcagtcct gcctctgcca cagtctctct gttgtcccca catctaccca 6000 acttcctgta ctgttgccct tctgatgtta ataaaagcag ctgttactcc caaaaaaaaa 6060 aaaaaaaaa 6069 <210> 33 <211> 3478 <212> DNA <213> Homo sapiens exonuclease 1 (EXO1) <400> 33 aaattgaaag gtcagccttt cgcgcgctgt gtaggcaagt tacccgtgtt ctgcgttgcc 60 ggccgtgggt gctctggcca cagtgagtta ggggcgtcgg agcgggtttc tccaaccgca 120 atcggctccg ctcaagggga ggaggagagt cccttctcgg aaggcctaag gaaacgtgtc 180 gtctggaatg ggcttggggg ccacgcctgc acatctccgc gagacagagg gataaagtga 240 agatggtgct gttattgtta cctcgagtgc cacatgcgac ctctgagata tgtacacagt 300 cattcttact atcgcactca gccattctta ctacgctaaa gaagaaataa ttattcgagg 360 atatttgcct ggcccagaag aaacttatgt aaatttcatg aactattata tccgttttcc 420 tcggagtgag agaaaactct ttttagatat catctgagag aactagtgaa tcccagtcac 480 tgagtggagt tgagagtcta agaacctctg aaatttgaga actgctggac cagagccttt 540 agagctctga taaggtgtca acagggtagt taatttggca ccatggggat acagggattg 600 ctacaattta tcaaagaagc ttcagaaccc atccatgtga ggaagtataa agggcaggta 660 gtagctgtgg atacatattg ctggcttcac aaaggagcta ttgcttgtgc tgaaaaacta 720 gccaaaggtg aacctactga taggtatgta ggattttgta tgaaatttgt aaatatgtta 780 ctatctcatg ggatcaagcc tattctcgta tttgatggat gtactttacc ttctaaaaag 840 gaagtagaga gatctagaag agaaagacga caagccaatc ttcttaaggg aaagcaactt 900 cttcgtgagg ggaaagtctc ggaagctcga gagtgtttca cccggtctat caatatcaca 960 catgccatgg cccacaaagt aattaaagct gcccggtctc agggggtaga ttgcctcgtg 1020 gctccctatg aagctgatgc gcagttggcc tatcttaaca aagcgggaat tgtgcaagcc 1080 ataattacag aggactcgga tctcctagct tttggctgta aaaaggtaat tttaaagatg 1140 gaccagtttg gaaatggact tgaaattgat caagctcggc taggaatgtg cagacagctt 1200 ggggatgtat tcacggaaga gaagtttcgt tacatgtgta ttctttcagg ttgtgactac 1260 ctgtcatcac tgcgtgggat tggattagca aaggcatgca aagtcctaag actagccaat 1320 aatccagata tagtaaaggt tatcaagaaa attggacatt atctcaagat gaatatcacg 1380 gtaccagagg attacatcaa cgggtttatt cgggccaaca ataccttcct ctatcagcta 1440 gtttttgatc ccatcaaaag gaaacttatt cctctgaacg cctatgaaga tgatgttgat 1500 cctgaaacac taagctacgc tgggcaatat gttgatgatt ccatagctct tcaaatagca 1560 cttggaaata aagatataaa tacttttgaa cagatcgatg actacaatcc agacactgct 1620 atgcctgccc attcaagaag tcatagttgg gatgacaaaa catgtcaaaa gtcagctaat 1680 gttagcagca tttggcatag gaattactct cccagaccag agtcgggtac tgtttcagat 1740 gccccacaat tgaaggaaaa tccaagtact gtgggagtgg aacgagtgat tagtactaaa 1800 gggttaaatc tcccaaggaa atcatccatt gtgaaaagac caagaagtgc agagctgtca 1860 gaagatgacc tgttgagtca gtattctctt tcatttacga agaagaccaa gaaaaatagc 1920 tctgaaggca ataaatcatt gagcttttct gaagtgtttg tgcctgacct ggtaaatgga 1980 cctactaaca aaaagagtgt aagcactcca cctaggacga gaaataaatt tgcaacattt 2040 ttacaaagga aaaatgaaga aagtggtgca gttgtggttc cagggaccag aagcaggttt 2100 ttttgcagtt cagattctac tgactgtgta tcaaacaaag tgagcatcca gcctctggat 2160 gaaactgctg tcacagataa agagaacaat ctgcatgaat cagagtatgg agaccaagaa 2220 ggcaagagac tggttgacac agatgtagca cgtaattcaa gtgatgacat tccgaataat 2280 catattccag gtgatcatat tccagacaag gcaacagtgt ttacagatga agagtcctac 2340 tcttttgaga gcagcaaatt tacaaggacc atttcaccac ccactttggg aacactaaga 2400 agttgtttta gttggtctgg aggtcttgga gatttttcaa gaacgccgag cccctctcca 2460 agcacagcat tgcagcagtt ccgaagaaag agcgattccc ccacctcttt gcctgagaat 2520 aatatgtctg atgtgtcgca gttaaagagc gaggagtcca gtgacgatga gtctcatccc 2580 ttacgagaag aggcatgttc ttcacagtcc caggaaagtg gagaattctc actgcagagt 2640 tcaaatgcat caaagctttc tcagtgctct agtaaggact ctgattcaga ggaatctgat 2700 tgcaatatta agttacttga cagtcaaagt gaccagacct ccaagctacg tttatctcat 2760 ttctcaaaaa aagacacacc tctaaggaac aaggttcctg ggctatataa gtccagttct 2820 gcagactctc tttctacaac caagatcaaa cctctaggac ctgccagagc cagtgggctg 2880 agcaagaagc cggcaagcat ccagaagaga aagcatcata atgccgagaa caagccgggg 2940 ttacagatca aactcaatga gctctggaaa aactttggat ttaaaaaaga ttctgaaaag 3000 cttcctcctt gtaagaaacc cctgtcccca gtcagagata acatccaact aactccagaa 3060 gcggaagagg atatatttaa caaacctgaa tgtggccgtg ttcaaagagc aatattccag 3120 taaatgcaga ctgctgcaaa gcttttgcct gcaagagaat ctgatcaatt tgaagtccct 3180 gtttgggaat gaggcactta tcagcatgaa gaattttttc tcattctgtg ccattttaaa 3240 aatagaatac attttgtata ttaactttat aattgggttg tggttttttt gctcagcttt 3300 ttatattttt ataagaagct aaatagaaga ataattgtat ctctgacagg tttttggagg 3360 ttttagtgtt aattgggaaa atcctctgga gtttataaaa gtctactcta aatatttctg 3420 taatgttgtc aagtagaaag atagtaaatg gagaaactac aaaaaaaaaa aaaaaaaa 3478 <210> 34 <211> 1530 <212> DNA <213> Homo sapiens cyclin B2 (CCNB2) <400> 34 aatcctggaa caaggctaca gcgtcgaaga tccccagcgc tgcgggctcg gagagcagtc 60 ctaacggcgc ctcgtacgct agtgtcctcc cttttcagtc cgcgtccctc cctgggccgg 120 gctggcactc ttgccttccc cgtccctcat ggcgctgctc cgacgcccga cggtgtccag 180 tgatttggag aatattgaca caggagttaa ttctaaagtt aagagtcatg tgactattag 240 gcgaactgtt ttagaagaaa ttggaaatag agttacaacc agagcagcac aagtagctaa 300 gaaagctcag aacaccaaag ttccagttca acccaccaaa acaacaaatg tcaacaaaca 360 actgaaacct actgcttctg tcaaaccagt acagatggaa aagttggctc caaagggtcc 420 ttctcccaca cctgaggatg tctccatgaa ggaagagaat ctctgccaag ctttttctga 480 tgccttgctc tgcaaaatcg aggacattga taacgaagat tgggagaacc ctcagctctg 540 cagtgactac gttaaggata tctatcagta tctcaggcag ctggaggttt tgcagtccat 600 aaacccacat ttcttagatg gaagagatat aaatggacgc atgcgtgcca tcctagtgga 660 ttggctggta caagtccact ccaagtttag gcttctgcag gagactctgt acatgtgcgt 720 tggcattatg gatcgatttt tacaggttca gccagtttcc cggaagaagc ttcaattagt 780 tgggattact gctctgctct tggcttccaa gtatgaggag atgttttctc caaatattga 840 agactttgtt tacatcacag acaatgctta taccagttcc caaatccgag aaatggaaac 900 tctaattttg aaagaattga aatttgagtt gggtcgaccc ttgccactac acttcttaag 960 gcgagcatca aaagccgggg aggttgatgt tgaacagcac actttagcca agtatttgat 1020 ggagctgact ctcatcgact atgatatggt gcattatcat ccttctaagg tagcagcagc 1080 tgcttcctgc ttgtctcaga aggttctagg acaaggaaaa tggaacttaa agcagcagta 1140 ttacacagga tacacagaga atgaagtatt ggaagtcatg cagcacatgg ccaagaatgt 1200 ggtgaaagta aatgaaaact taactaaatt catcgccatc aagaataagt atgcaagcag 1260 caaactcctg aagatcagca tgatccctca gctgaactca aaagccgtca aagaccttgc 1320 ctccccactg ataggaaggt cctaggctgc cgtgggccct ggggatgtgt gcttcattgt 1380 gccctttttc ttattggttt agaactcttg attttgtaca tagtcctctg gtctatctca 1440 tgaaacctct tctcagacca gttttctaaa catatattga ggaaaaataa agcgattggt 1500 ttttcttaag gtaaaaaaaa aaaaaaaaaa 1530 <210> 35 <211> 3315 <212> DNA <213> Homo sapiens Rac GTPase activating protein 1 (RACGAP1) <400> 35 aataaatttc tctgtgattg gttggtgaag gttttcaaac cggagctgtg ggcgcggcgc 60 tgctctgccg ttgggtgagg cgcggagcga agtgaagggt ggcccaggtg gggccaggct 120 gactgaatgt atctcctagc tatggactaa ataatacatg gggggaaata aacaagtatt 180 catgagggtg aaaatgtgac ccagcaggaa aattacaact attttcaatt gacgttgaat 240 aggatgagtc atggaattta agtgatttac tgaagattat actactggta gatagaagag 300 ctaaagaaag atggatacta tgatgctgaa tgtgcggaat ctgtttgagc agcttgtgcg 360 ccgggtggag attctcagtg aaggaaatga agtccaattt atccagttgg cgaaggactt 420 tgaggatttc cgtaaaaagt ggcagaggac tgaccatgag ctggggaaat acaaggatct 480 tttgatgaaa gcagagactg agcgaagtgc tctggatgtt aagctgaagc atgcacgtaa 540 tcaggtggat gtagagatca aacggagaca gagagctgag gctgactgcg aaaagctgga 600 acgacagatt cagctgattc gagagatgct catgtgtgac acatctggca gcattcaact 660 aagcgaggag caaaaatcag ctctggcttt tctcaacaga ggccaaccat ccagcagcaa 720 tgctgggaac aaaagactat caaccattga tgaatctggt tccattttat cagatatcag 780 ctttgacaag actgatgaat cactggattg ggactcttct ttggtgaaga ctttcaaact 840 gaagaagaga gaaaagaggc gctctactag ccgacagttt gttgatggtc cccctggacc 900 tgtaaagaaa actcgttcca ttggctctgc agtagaccag gggaatgaat ccatagttgc 960 aaaaactaca gtgactgttc ccaatgatgg cgggcccatc gaagctgtgt ccactattga 1020 gactgtgcca tattggacca ggagccgaag gaaaacaggt actttacaac cttggaacag 1080 tgactccacc ctgaacagca ggcagctgga gccaagaact gagacagaca gtgtgggcac 1140 gccacagagt aatggaggga tgcgcctgca tgactttgtt tctaagacgg ttattaaacc 1200 tgaatcctgt gttccatgtg gaaagcggat aaaatttggc aaattatctc tgaagtgtcg 1260 agactgtcgt gtggtctctc atccagaatg tcgggaccgc tgtccccttc cctgcattcc 1320 taccctgata ggaacacctg tcaagattgg agagggaatg ctggcagact ttgtgtccca 1380 gacttctcca atgatcccct ccattgttgt gcattgtgta aatgagattg agcaaagagg 1440 tctgactgag acaggcctgt ataggatctc tggctgtgac cgcacagtaa aagagctgaa 1500 agagaaattc ctcagagtga aaactgtacc cctcctcagc aaagtggatg atatccatgc 1560 tatctgtagc cttctaaaag actttcttcg aaacctcaaa gaacctcttc tgacctttcg 1620 ccttaacaga gcctttatgg aagcagcaga aatcacagat gaagacaaca gcatagctgc 1680 catgtaccaa gctgttggtg aactgcccca ggccaacagg gacacattag ctttcctcat 1740 gattcacttg cagagagtgg ctcagagtcc acatactaaa atggatgttg ccaatctggc 1800 taaagtcttt ggccctacaa tagtggccca tgctgtgccc aatccagacc cagtgacaat 1860 gttacaggac atcaagcgtc aacccaaggt ggttgagcgc ctgctttcct tgcctctgga 1920 gtattggagt cagttcatga tggtggagca agagaacatt gaccccctac atgtcattga 1980 aaactcaaat gccttttcaa caccacagac accagatatt aaagtgagtt tactgggacc 2040 tgtgaccact cctgaacatc agcttctcaa gactccttca tctagttccc tgtcacagag 2100 agtccgttcc accctcacca agaacactcc tagatttggg agcaaaagca agtctgccac 2160 taacctagga cgacaaggca acttttttgc ttctccaatg ctcaagtgaa gtcacatctg 2220 cctgttactt cccagcattg actgactata agaaaggaca catctgtact ctgctctgca 2280 gcctcctgta ctcattacta cttttagcat tctccaggct tttactcaag tttaattgtg 2340 catgagggtt ttattaaaac tatatatatc tccccttcct tctcctcaag tcacataata 2400 tcagcacttt gtgctggtca ttgttgggag cttttagatg agacatcttt ccaggggtag 2460 aagggttagt atggaattgg ttgtgattct ttttggggaa gggggttatt gttcctttgg 2520 cttaaagcca aatgctgctc atagaatgat ctttctctag tttcatttag aactgatttc 2580 cgtgagacaa tgacagaaac cctacctatc tgataagatt agcttgtctc agggtgggaa 2640 gtgggagggc agggcaaaga aaggattaga ccagaggatt taggatgcct ccttctaaga 2700 accagaagtt ctcattcccc attatgaact gagctataat atggagcttt cataaaaatg 2760 ggatgcattg aggacagaac tagtgatggg agtatgcgta gctttgattt ggatgattag 2820 gtctttaata gtgttgagtg gcacaacctt gtaaatgtga aagtacaact cgtatttatc 2880 tctgatgtgc tgctggctga actttgggtt catttggggt caaagccagt ttttctttta 2940 aaattgaatt cattctgatg cttggccccc atacccccaa ccttgtccag tggagcccaa 3000 cttctaaagg tcaatatatc atcctttggc atcccaacta acaataaaga gtaggctata 3060 agggaagatt gtcaatattt tgtggtaaga aaagctacag tcattttttc tttgcacttt 3120 ggatgctgaa atttttccca tggaacatag ccacatctag atagatgtga gctttttctt 3180 ctgttaaaat tattcttaat gtctgtaaaa acgattttct tctgtagaat gtttgacttc 3240 gtattgaccc ttatctgtaa aacacctatt tgggataata tttggaaaaa aagtaaatag 3300 ctttttcaaa atgaa 3315 <210> 36 <211> 2035 <212> DNA <213> Homo sapiens CHK1 checkpoint homolog (S. pombe) (CHEK1) <400> 36 acccccacct ctccctcctc cttccccagt cgttcgccgg aaagcatttg tctcccacct 60 cttcataaca acaattaatt tcctctgggg cctgaggagg gcagaatttc aaccttcggt 120 gtgcttggga gtggcgattg tgatttacac gacaaaatgc cgaggtgctc ggtggagtca 180 tggcagtgcc ctttgtggaa gactgggact tggtgcaaac cctgggagaa ggtgcctatg 240 gagaagttca acttgctgtg aatagagtaa ctgaagaagc agtcgcagtg aagattgtag 300 atatgaagcg tgccgtagac tgtccagaaa atattaagaa agagatctgt atcaataaaa 360 tgctaaatca tgaaaatgta gtaaaattct atggtcacag gagagaaggc aatatccaat 420 atttatttct ggagtactgt agtggaggag agctttttga cagaatagag ccagacatag 480 gcatgcctga accagatgct cagagattct tccatcaact catggcaggg gtggtttatc 540 tgcatggtat tggaataact cacagggata ttaaaccaga aaatcttctg ttggatgaaa 600 gggataacct caaaatctca gactttggct tggcaacagt atttcggtat aataatcgtg 660 agcgtttgtt gaacaagatg tgtggtactt taccatatgt tgctccagaa cttctgaaga 720 gaagagaatt tcatgcagaa ccagttgatg tttggtcctg tggaatagta cttactgcaa 780 tgctcgctgg agaattgcca tgggaccaac ccagtgacag ctgtcaggag tattctgact 840 ggaaagaaaa aaaaacatac ctcaaccctt ggaaaaaaat cgattctgct cctctagctc 900 tgctgcataa aatcttagtt gagaatccat cagcaagaat taccattcca gacatcaaaa 960 aagatagatg gtacaacaaa cccctcaaga aaggggcaaa aaggccccga gtcacttcag 1020 gtggtgtgtc agagtctccc agtggatttt ctaagcacat tcaatccaat ttggacttct 1080 ctccagtaaa cagtgcttct agtgaagaaa atgtgaagta ctccagttct cagccagaac 1140 cccgcacagg tctttcctta tgggatacca gcccctcata cattgataaa ttggtacaag 1200 ggatcagctt ttcccagccc acatgtcctg atcatatgct tttgaatagt cagttacttg 1260 gcaccccagg atcctcacag aacccctggc agcggttggt caaaagaatg acacgattct 1320 ttaccaaatt ggatgcagac aaatcttatc aatgcctgaa agagacttgt gagaagttgg 1380 gctatcaatg gaagaaaagt tgtatgaatc aggttactat atcaacaact gataggagaa 1440 acaataaact cattttcaaa gtgaatttgt tagaaatgga tgataaaata ttggttgact 1500 tccggctttc taagggtgat ggattggagt tcaagagaca cttcctgaag attaaaggga 1560 agctgattga tattgtgagc agccagaaga tttggcttcc tgccacatga tcggaccatc 1620 ggctctgggg aatcctggtg aatatagtgc tgctatgttg acattattct tcctagagaa 1680 gattatcctg tcctgcaaac tgcaaatagt agttcctgaa gtgttcactt ccctgtttat 1740 ccaaacatct tccaatttat tttgtttgtt cggcatacaa ataataccta tatcttaatt 1800 gtaagcaaaa ctttggggaa aggatgaata gaattcattt gattatttct tcatgtgtgt 1860 ttagtatctg aatttgaaac tcatctggtg gaaaccaagt ttcaggggac atgagttttc 1920 cagcttttat acacacgtat ctcattttta tcaaaacatt ttgtttaatt caaaaagtac 1980 atattccatg ttgatttaat tctaagatga accaataaag acataattct tgtga 2035 <210> 37 <211> 5019 <212> DNA <213> Homo sapiens SCL/TAL1 interrupting locus (STIL) <400> 37 agttcccgcg accccaacgt cccagaggcg gggccggagt cggcggtggc gctccttgga 60 gccggctccc gctcctaccc tgcaaacaga cctcagctcc gcggaagttg cggatactga 120 ggatttggaa ttaaagaaat cattcaccag acatcatgga gcctatatat ccttttgcac 180 ggccccagat gaataccagg tttccttcaa gcaggatggt acctttccac tttcctccat 240 caaaatgtgc actttggaac ccaacgccaa ctggagattt catctactta catctcagtt 300 actacagaaa tccaaagctt gtggtgactg agaagaccat ccgacttgct tatcgtcatg 360 ctaagcagaa taaaaaaaat tcgtcatgct ttttacttgg ttctctgaca gcagacgaag 420 atgaagaagg tgtaacattg acagtagatc gctttgatcc tggtcgagaa gtacctgaat 480 gcctagaaat aacccctact gcttctcttc ctggggactt tttgattcca tgcaaagttc 540 atactcaaga actttgttca agagaaatga tagttcacag tgtagatgac ttcagttcag 600 ctttaaaggc tctacagtgc catatatgta gcaaagattc cttggactgt ggtaagctgc 660 tttccctaag agttcatatc acttccaggg agagtttgga cagtgtggaa tttgacttgc 720 attgggcagc agtaactcta gcaaataact ttaaatgcac acctgtgaag cccatcccca 780 ttattccaac agctctggca agaaacttga gcagtaatct gaatatttct caagttcaag 840 ggacttataa atatggatat cttaccatgg atgaaacacg caaattgtta cttttgttgg 900 aatctgatcc caaggtttat tctctaccat tggtgggaat ttggctgtct ggaattacac 960 atatctatag tcctcaggta tgggcttgct gtttgcgata catattcaat tcttctgttc 1020 aagaaagggt tttttcagaa tctggaaatt tcatcatagt tctctattct atgacacata 1080 aggaacctga gttttatgaa tgcttccctt gtgatggcaa gatacctgac tttcggtttc 1140 agttgctaac cagtaaggaa acattacatc ttttcaaaaa tgttgaacct cctgacaaaa 1200 atccaatccg ttgtgaactg agcgctgaaa gccaaaatgc agaaacagag tttttcagta 1260 aggcttccaa gaatttttca attaagaggt cttcccaaaa gttatcttct gggaagatgc 1320 caatacatga tcacgactct ggtgttgaag atgaagattt ttctccaaga ccaattccta 1380 gtcctcatcc agtgagtcag aagatttcta agatccaacc atcagttcct gaactttcac 1440 ttgtgttgga tggcaatttc atagaatcaa accctctgcc tactccattg gaaatggtga 1500 ataatgaaaa tcctcctttg attaaccact tggaacactt gaagccattg caaccccagc 1560 tttatgatga gaaacacagt ccagaagttg aagctggaga gccttccttg agaggaatac 1620 caaatcagtt aaaccaggat aaaccagctc ttttgagaca ctgcaaagta agacagccac 1680 ctgcctataa gaaagggaac ccccatacca ggaacagtat taaaccatct tctcataatg 1740 ggccatctca tgatatattt gaaaagctcc aaacagtttc tgctggaaat gtacaaaacg 1800 aagagtatcc tataagaccc tccacactta attctaggca gtcttctctt gccccgcagt 1860 cccaaccaca cgattttgtt ttttcacccc ataattcagg aagaccaatg gaacttcaga 1920 tacctactcc cccactgcca tcttactgtt ccacaaacgt ttgcaggtgt tgtcagcatc 1980 atagtcatat tcaatatagt ccgctaaatt cttggcaagg agcaaacaca gttggatcca 2040 ttcaagatgt ccagtctgaa gcccttcaaa agcattcatt atttcaccca agtggatgtc 2100 cagccctgta ctgtaatgca ttctgttctt caagtagtcc tatagccttg agacctcagg 2160 gagatatggg cagttgttct ccccacagca atattgaacc atcgcctgtg gcaagaccgc 2220 cttcacatat ggacttatgt aacccacagc cttgcacagt gtgcatgcac acacccaaga 2280 ctgagtcaga taatggaatg atgggactat ctccagatgc atatcggttc ctcacagaac 2340 aagacagaca gctaagacta cttcaggcac agattcagcg tttgttggaa gcacagtctc 2400 tgatgccctg ttcccctaag acaactgctg ttgaagacac agtgcaagct ggaagacaaa 2460 tggagttggt ttctgtggaa gcacagtctt cccctggctt gcacatgaga aaaggtgtaa 2520 gcattgctgt gagcacaggt gctagcttgt tttggaatgc agcaggtgag gatcaagagc 2580 ctgactctca aatgaagcaa gatgatacca aaatttccag tgaggacatg aatttttctg 2640 tcgatattaa taatgaagtc acaagtcttc caggtagtgc atcttcatta aaagcagttg 2700 atattcccag ttttgaagag agcaacattg ctgtggaaga agaatttaac cagccacttt 2760 ctgtatccaa cagctcttct ctagttgtga gaaaagaacc tgatgtacct gtgttctttc 2820 caagtggcca gctggcagaa agtgtaagca tgtgtttaca gactggacca acagggggtg 2880 ccagtaacaa ttctgaaaca tcagaggaac caaaaattga gcatgtaatg caacccttgc 2940 ttcatcaacc atcagataac cagaaaattt accaggattt attgggtcaa gtaaaccacc 3000 tattaaatag ttcctccaag gaaactgagc agccgtctac caaagcagta attatcagtc 3060 atgaatgcac cagaacccaa aacgtttacc atacaaagaa aaaaacacat cattcaagac 3120 tggtggacaa agattgtgtc cttaatgcaa ctcttaagca actaagaagc cttggagtaa 3180 aaattgattc tcccactaaa gtgaagaaaa atgcacataa cgtggatcac gccagtgtgt 3240 tggcatgcat cagcccagaa gcagtgatct ctggattaaa ctgcatgtca tttgctaatg 3300 ttggcatgag cggcttaagc cccaatggtg tggatttgag catggaggca aatgctatag 3360 ctctgaaata tttaaatgaa aatcagctgt cacaactgtc tgtcactcga tcgaaccaaa 3420 ataattgtga cccattcagc cttctccata ttaatacaga cagaagcaca gtggggctta 3480 gtttaatttc accaaacaac atgtcatttg caaccaaaaa atatatgaag agatatggac 3540 tcctacaaag cagtgacaat agtgaagatg aagaggaacc tcccgacaat gcagatagca 3600 agagtgaata tttattgaat cagaacctta ggtccatacc tgaacagctt ggtggtcaga 3660 aagagccttc taagaatgac catgaaataa ttaattgttc taactgtgaa tctgtgggga 3720 ccaacgcaga tacgccagta ttgagaaata ttacaaatga agttttgcag acaaaagcaa 3780 aacagcagtt gactgaaaag ccagctttct tagtaaagaa ccttaaacca agtcctgcag 3840 tgaaccttcg aaccgggaaa gcagagttca ctcaacatcc tgagaaagaa aatgaagggg 3900 acattacaat ttttcctgaa agtttgcaac cttctgaaac gctaaagcag atgaatagca 3960 tgaattcagt aggcaccttc ttagatgtaa aacgtctcag acagttacca aaattatttt 4020 aaccttttaa ctccctgccc ttttaataca gggacagggt gtctcctgaa gatacttagg 4080 gaaaacagga gcctaccaca aggctcctga tcattctgga gtcactgttt cttggtagca 4140 gccaattggg aagagtgact tctgtgagat ggctggctgg tgataggact aagttctcat 4200 tgttcaaata gagctgttca acatcactga aacctttaag aaaagccctg agatcagtta 4260 ttcctacaag tttaagtagt agacagatac tatccagctc taagtctcaa ctgctctttt 4320 atactgtact tttttttttg agacggagtt ttgctcttgt agcccaggct ggagtgcaat 4380 ggcaggatct cagatcactg caacctctgc ctcctgggtt caagcgattt tcctgcttca 4440 tcttcccagg tagctgggat tacaggcatg tgccacaacg cctggctaat tttgtatttt 4500 tagtagagac tggtttctcc atgttggtca ggctggtctc aaactcccga cctcaggtga 4560 tccgcccgcc tcggcctcct aaagtgctgg gattacaggc gtgagccact gcgcccagct 4620 atactgtata ttttaagaag ttccagcatg ttgcatctct gcatttatcc tatatcatta 4680 aaagaacata agttatcatg gtgttgggta aattagcgaa atcaaccctt cctaagttta 4740 agggaaaagt tatttttaaa aacaacttaa taaaaactta cactctttta tacaagagtg 4800 tatttcccct taattaggat gcatgttgat taaactcgag atacagcttt ttgcagtatg 4860 gtgggttggt tttggtgtaa catcttcaac atgtcacact ggctatcaaa gaataagaaa 4920 attattgagt atgagtgtgt tttataaact ttctgagttt ttcagatgtc ttaatatttt 4980 ttaatagaac ttaataaaat gtctagattg actattttc 5019 <210> 38 <211> 2011 <212> DNA <213> Homo sapiens karyopherin alpha 2 (RAG cohort 1, importin alpha 1) (KPNA2) <400> 38 gccacacggt ctttgagctg agtcgaggtg gaccctttga acgcagtcgc cctacagccg 60 ctgattcccc ccgcatcgcc tcccgtggaa gcccaggccc gcttcgcagc tttctccctt 120 tgtctcataa ccatgtccac caacgagaat gctaatacac cagctgcccg tcttcacaga 180 ttcaagaaca agggaaaaga cagtacagaa atgaggcgtc gcagaataga ggtcaatgtg 240 gagctgagga aagctaagaa ggatgaccag atgctgaaga ggagaaatgt aagctcattt 300 cctgatgatg ctacttctcc gctgcaggaa aaccgcaaca accagggcac tgtaaattgg 360 tctgttgatg acattgtcaa aggcataaat agcagcaatg tggaaaatca gctccaagct 420 actcaagctg ccaggaaact actttccaga gaaaaacagc cccccataga caacataatc 480 cgggctggtt tgattccgaa atttgtgtcc ttcttgggca gaactgattg tagtcccatt 540 cagtttgaat ctgcttgggc actcactaac attgcttctg ggacatcaga acaaaccaag 600 gctgtggtag atggaggtgc catcccagca ttcatttctc tgttggcatc tccccatgct 660 cacatcagtg aacaagctgt ctgggctcta ggaaacattg caggtgatgg ctcagtgttc 720 cgagacttgg ttattaagta cggtgcagtt gacccactgt tggctctcct tgcagttcct 780 gatatgtcat ctttagcatg tggctactta cgtaatctta cctggacact ttctaatctt 840 tgccgcaaca agaatcctgc acccccgata gatgctgttg agcagattct tcctacctta 900 gttcggctcc tgcatcatga tgatccagaa gtattagcag atacctgctg ggctatttcc 960 taccttactg atggtccaaa tgaacgaatt ggcatggtgg tgaaaacagg agttgtgccc 1020 caacttgtga agcttctagg agcttctgaa ttgccaattg tgactcctgc cctaagagcc 1080 atagggaata ttgtcactgg tacagatgaa cagactcagg ttgtgattga tgcaggagca 1140 ctcgccgtct ttcccagcct gctcaccaac cccaaaacta acattcagaa ggaagctacg 1200 tggacaatgt caaacatcac agccggccgc caggaccaga tacagcaagt tgtgaatcat 1260 ggattagtcc cattccttgt cagtgttctc tctaaggcag attttaagac acaaaaggaa 1320 gctgtgtggg ccgtgaccaa ctataccagt ggtggaacag ttgaacagat tgtgtacctt 1380 gttcactgtg gcataataga accgttgatg aacctcttaa ctgcaaaaga taccaagatt 1440 attctggtta tcctggatgc catttcaaat atctttcagg ctgctgagaa actaggtgaa 1500 actgagaaac ttagtataat gattgaagaa tgtggaggct tagacaaaat tgaagctcta 1560 caaaaccatg aaaatgagtc tgtgtataag gcttcgttaa gcttaattga gaagtatttc 1620 tctgtagagg aagaggaaga tcaaaacgtt gtaccagaaa ctacctctga aggctacact 1680 ttccaagttc aggatggggc tcctgggacc tttaactttt agatcatgta gctgagacat 1740 aaatttgttg tgtactacgt ttggtatttt gtcttattgt ttctctacta agaactcttt 1800 cttaaatgtg gtttgttact gtagcacttt ttacactgaa actatacttg aacagttcca 1860 actgtacata catactgtat gaagcttgtc ctctgactag gtttctaatt tctatgtgga 1920 atttcctatc ttgcagcatc ctgtaaataa acattcaagt ccaccctttt cttgacttca 1980 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a 2011 <210> 39 <211> 1923 <212> DNA <213> Homo sapiens cyclin-dependent kinase 1 (CDK1) <400> 39 agcgcggtga gtttgaaact gctcgcactt ggcttcaaag ctggctcttg gaaattgagc 60 ggagagcgac gcggttgttg tagctgccgc tgcggccgcc gcggaataat aagccgggat 120 ctaccatacc cattgactaa ctatggaaga ttataccaaa atagagaaaa ttggagaagg 180 tacctatgga gttgtgtata agggtagaca caaaactaca ggtcaagtgg tagccatgaa 240 aaaaatcaga ctagaaagtg aagaggaagg ggttcctagt actgcaattc gggaaatttc 300 tctattaaag gaacttcgtc atccaaatat agtcagtctt caggatgtgc ttatgcagga 360 ttccaggtta tatctcatct ttgagtttct ttccatggat ctgaagaaat acttggattc 420 tatccctcct ggtcagtaca tggattcttc acttgttaag agttatttat accaaatcct 480 acaggggatt gtgttttgtc actctagaag agttcttcac agagacttaa aacctcaaaa 540 tctcttgatt gatgacaaag gaacaattaa actggctgat tttggccttg ccagagcttt 600 tggaatacct atcagagtat atacacatga ggtagtaaca ctctggtaca gatctccaga 660 agtattgctg gggtcagctc gttactcaac tccagttgac atttggagta taggcaccat 720 atttgctgaa ctagcaacta agaaaccact tttccatggg gattcagaaa ttgatcaact 780 cttcaggatt ttcagagctt tgggcactcc caataatgaa gtgtggccag aagtggaatc 840 tttacaggac tataagaata catttcccaa atggaaacca ggaagcctag catcccatgt 900 caaaaacttg gatgaaaatg gcttggattt gctctcgaaa atgttaatct atgatccagc 960 caaacgaatt tctggcaaaa tggcactgaa tcatccatat tttaatgatt tggacaatca 1020 gattaagaag atgtagcttt ctgacaaaaa gtttccatat gttatatcaa cagatagttg 1080 tgtttttatt gttaactctt gtctattttt gtcttatata tatttctttg ttatcaaact 1140 tcagctgtac ttcgtcttct aatttcaaaa atataactta aaaatgtaaa tattctatat 1200 gaatttaaat ataattctgt aaatgtgtgt aggtctcact gtaacaacta tttgttacta 1260 taataaaact ataatattga tgtcaggaat caggaaaaaa tttgagttgg cttaaatcat 1320 ctcagtcctt atggcagttt tattttcctg tagttggaac tactaaaatt taggaaaatg 1380 ctaagttcaa gtttcgtaat gctttgaagt atttttatgc tctgaatgtt taaatgttct 1440 catcagtttc ttgccatgtt gttaactata caacctggct aaagatgaat atttttctac 1500 tggtatttta atttttgacc taaatgttta agcattcgga atgagaaaac tatacagatt 1560 tgagaaatga tgctaaattt ataggagttt tcagtaactt aaaaagctaa catgagagca 1620 tgccaaaatt tgctaagtct tacaaagatc aagggctgtc cgcaacaggg aagaacagtt 1680 ttgaaaattt atgaactatc ttatttttag gtaggttttg aaagcttttt gtctaagtga 1740 attcttatgc cttggtcaga gtaataactg aaggagttgc ttatcttggc tttcgagtct 1800 gagtttaaaa ctacacattt tgacatagtg tttattagca gccatctaaa aaggctctaa 1860 tgtatattta actaaaatta ctagctttgg gaattaaact gtttaacaaa taaaaaaaaa 1920 aaa 1923 <210> 40 <211> 2993 <212> DNA <213> Homo sapiens discs, large (Drosophila) homolog-associated protein 5 (DLGAP5) <400> 40 agcaaaccaa tcgcaagcct cgttgagtgg aaggggtggg atcttccccg gaagtgttgg 60 ttaaagcccc tccaatcagc ggctcggtgc ggcaagtttg aatttcgtgg aggctcgggt 120 tgtgagggtt cctgcttcgg agtcggcggt ggtcgtccag accgagtgtt ctttactttt 180 tgtttggttg aggtttcacg ctagaaggtg gctcaggatg tcttcatcac attttgccag 240 tcgacacagg aaggatataa gtactgaaat gattagaact aaaattgctc ataggaaatc 300 actgtctcag aaagaaaata gacataagga atacgaacga aatagacact ttggtttgaa 360 agatgtaaac attccaacct tggaaggtag aattcttgtt gaattagatg agacatctca 420 agggcttgtt ccagaaaaga ccaatgttaa gccaagggca atgaaaacta ttctaggtga 480 tcaacgaaaa cagatgctcc aaaaatacaa agaagaaaag caacttcaaa aattgaaaga 540 gcagagagag aaagctaaac gaggaatatt taaagtgggt cgttatagac ctgatatgcc 600 ttgttttctt ttatcaaacc agaatgctgt gaaagctgag ccaaaaaagg ctattccatc 660 ttctgtacgg attacaaggt caaaggccaa agaccaaatg gagcagacta agattgataa 720 cgagagtgat gttcgagcaa tccgacctgg tccaagacaa acttctgaaa agaaagtgtc 780 agacaaagag aaaaaagttg tgcagcctgt aatgcccacg tcgttgagaa tgactcgatc 840 agctactcaa gcagcaaagc aggttcccag aacagtctca tctaccacag caagaaagcc 900 agtcacaaga gctgctaatg aaaacgaacc agaaggaaag gtgccaagta aaggaagacc 960 tgccaaaaat gtagaaacaa aacccgacaa gggtatttct tgtaaagtcg atagtgaaga 1020 aaatactttg aattcacaaa ctaatgcaac aagtggaatg aatccagatg gagtcttatc 1080 aaaaatggaa aacttacctg agataaatac tgcaaaaata aaagggaaga attcctttgc 1140 acctaaggat tttatgtttc agccactgga tggtctgaag acctatcaag taacacctat 1200 gactcccaga agtgccaatg cttttttgac acccagttac acctggactc ctttaaaaac 1260 agaagttgat gagtctcaag caacaaaaga aattttggca caaaaatgta aaacttactc 1320 taccaagaca atacagcaag attcaaataa attgccatgt cctttgggtc ctctaactgt 1380 ttggcatgaa gaacatgttt taaataaaaa tgaagctact actaaaaatt taaatggcct 1440 tccaataaaa gaagtcccat cacttgaaag aaatgaaggt cgaattgctc agccccacca 1500 tggtgtgcca tatttcagaa atatcctcca gtcagaaact gagaaattaa cttcacattg 1560 cttcgagtgg gacaggaaac ttgaattgga cattccagat gatgctaaag atcttattcg 1620 cacagcagtt ggtcaaacaa gactccttat gaaggaaagg tttaaacagt ttgaaggact 1680 ggttgatgat tgtgaatata aacgaggtat aaaggagact acctgtacag atctggatgg 1740 attttgggat atggttagtt ttcagataga agatgtaatc cacaaattca acaatctgat 1800 caaacttgag gaatctgggt ggcaagtcaa taataatatg aatcataata tgaacaaaaa 1860 tgtctttagg aaaaaagttg tctcaggtat agcaagtaaa ccaaaacagg atgatgctgg 1920 aagaattgca gcgagaaatc gcctagctgc cataaaaaat gcaatgagag agagaattag 1980 gcaggaagaa tgtgctgaaa cagcagtttc tgtgatacca aaggaagttg ataaaatagt 2040 gttcgatgct ggatttttca gagttgaaag tcctgttaaa ttattctcag gactttctgt 2100 ctcttctgaa ggcccttctc aaagacttgg aacacctaag tctgtcaaca aagctgtatc 2160 tcagagtaga aatgagatgg gcattccaca acaaactaca tcaccagaaa atgccggtcc 2220 tcagaatacg aaaagtgaac atgtgaagaa gactttgttt ttgagtattc ctgaaagcag 2280 gagcagcata gaagatgctc agtgtcctgg attaccagat ttaattgaag aaaatcatgt 2340 tgtaaataag acagacttga aggtggattg tttatccagt gagagaatga gtttgcctct 2400 tcttgctggt ggagtagcag atgatattaa tactaacaaa aaagaaggaa tttcagatgt 2460 tgtggaagga atggaactga attcttcaat tacatcacag gatgttttga tgagtagccc 2520 tgaaaaaaat acagcttcac aaaatagcat cttagaagaa ggggaaacta aaatttctca 2580 gtcagaacta tttgataata aaagtctcac tactgaatgc caccttcttg attcaccagg 2640 tctaaactgc agtaatccat ttactcagct ggagaggaga catcaagaac atgccagaca 2700 catttctttt ggtggtaacc tgattacttt ttcacctcta caaccaggag aattttgaat 2760 ttaaaaataa atccaaacat tttccttcat attatcaatg cttatatatt ccttagacta 2820 ttgaaatttt ggagaaaatg tatttgtgtt cacttctata gcatataatg ttttaatatt 2880 ctgtgttcat caaagtgtat tttagatata ctctttctca agggaagtgg ggatattttg 2940 tacattttca acacagaata aaaaatgtac tgtgccttgc ctctcttgtt taa 2993 <210> 41 <211> 3217 <212> DNA <213> Homo sapiens CTP synthase (CTPS) <400> 41 tccctcgccc ggaggcagag atgcgctggc gcatcaccgc caggagccca cagtgaaaga 60 ccatcggatg gaaggcgacg cccagaactc caggagaccg ctgtgggagg acgcgaggcc 120 aggtgacgaa taggccaggc gtgagttccc aaacagcctc ctccccttca agagagtaag 180 cttgggccac aggctgggac ggaagcagag gggcagacac gccaccaccc gcccggcctc 240 gaacctacgg cggcacagtt cagcggaggc ggcccagcgg tcctgtcccg cgcctgcgca 300 ctccaggccc cgccccgccc cgcgccctcc aggcccggcc cgccctccaa cctctgcgtg 360 cgcacagcct agagcccgcc tccgtgaaag actgccgggc gcatgcggtc ggggttgttc 420 actggctgtc cggggctccg cgcgcgtcgc cggcccagct ctgtcgctga cgggaggatc 480 tgaagccggc cgcaggtcaa agagtaaaat gaagtacatt ctggttactg gtggtgttat 540 atcaggaatt ggaaaaggaa tcattgccag cagtgtgggc acaatactca agtcatgtgg 600 tttacatgta acttcaatca aaattgaccc ctacattaac attgatgcag gaacattctc 660 tccttatgag catggtgagg tttttgtgct ggatgatggt ggggaagtag accttgacct 720 gggtaactat gagcggttcc ttgacatccg cctcaccaag gacaataatc tgaccactgg 780 aaagatatac cagtatgtca ttaacaagga acggaaagga gattacttgg ggaaaactgt 840 ccaagttgtc cctcatatca cagatgcaat ccaggagtgg gtgatgagac aggcgttaat 900 acctgtagat gaagatggcc tggaacctca agtgtgtgtt attgagcttg gtggaaccgt 960 gggggacata gaaagcatgc cctttattga ggccttccgt cagttccaat tcaaggtcaa 1020 aagagagaac ttttgtaaca tccacgtcag tctagttccc cagccaagtt caacagggga 1080 acagaagact aaacctaccc agaatagtgt tcgggaactt agaggacttg ggctttcccc 1140 agatctggtt gtatgcaggt gctcaaatcc acttgacaca tcagtgaagg agaaaatatc 1200 aatgttctgc catgttgagc ctgaacaagt gatctgtgtc cacgatgtct catccatcta 1260 ccgagtcccc ttgttgttag aggagcaagg ggttgtagat tattttcttc gaagacttga 1320 ccttcctatt gagaggcagc caagaaaaat gctgatgaaa tggaaagaga tggctgacag 1380 atatgatcgc ttgctggaga cctgctctat tgcccttgtg ggcaaataca cgaagttctc 1440 agactcctat gcctctgtca ttaaggctct ggagcattct gcactggcca tcaaccacaa 1500 attggaaatc aagtacatag attctgcgga cttggagccc atcacctcgc aagaagagcc 1560 cgtgcgctac cacgaagctt ggcagaagct ctgtagtgct catggagtgc tggttccagg 1620 aggatttggt gttcgaggaa cagaaggaaa aatccaagca attgcctggg ctcggaatca 1680 gaaaaagcct tttttgggcg tgtgcttagg gatgcagttg gcagtggttg aattctcaag 1740 aaacgtgctg ggatggcaag atgccaattc tacagagttt gaccctacga ccagtcatcc 1800 cgtggtcgta gacatgccag aacacaaccc agggcagatg ggcggaacca tgaggctggg 1860 caagaggaga accctgttcc agaccaagaa ctcagtcatg aggaaactct atggagacgc 1920 agactacttg gaagagaggc accgccaccg atttgaggtg aatccagtct ggaaaaagtg 1980 tttggaagaa caaggcttga agtttgttgg ccaagatgtt gaaggagaga gaatggaaat 2040 tgtggagtta gaagatcatc ccttttttgt tggggttcag taccaccctg agttcctgtc 2100 caggcctatc aagccctccc caccatactt tggcctcctc ctggcctctg tggggcggct 2160 ctcacattac ctccagaaag gctgcaggct ctcacccagg gacacctata gtgacaggag 2220 tggaagcagc tcccctgact ctgaaatcac cgaactgaag tttccatcaa taaatcatga 2280 ctgatcttgt agcggatgat tcttcaagag acccttcaaa cttgggtaga gtttacagct 2340 ctgactttac actcggcttt ggagactttc tttaaattat gtttttatta agattatttt 2400 attatgcgga aaggtatttg ggaaacttgt cacttgcatg tcccatcacg tgtactggct 2460 cctctgtggt gtctgcctgt tgcgtgacac tctccttgca gttcttgagt tgcggcagaa 2520 catcgcgatg ggaaccgatg gtgggtgggg ctgcagagtg ccccatcggt caccttgttt 2580 ctcaactacc tcgcatcatt gcagatgcta gcgcgttgcc tgtcgctttc ccttggatac 2640 ctagaccgtt ataaagtgtg ccacatggac ttaccgagca tggagagagg attttagcta 2700 ggatttgaac acttggtgct gggaacctca gggtattgct tgccactaag ccatgaaacc 2760 agagacaaaa tctctatact gccctgagtt ggggggaatt ctcagtgcca actgtggctg 2820 gtcctcattc aaagggacgg tcagtttggt gtcaacatga aacaccaaga tgtctgtctc 2880 tgaagcgtga ttttaaaatc cccatgcctg tggctgcgct tcctatttct agggctggga 2940 aacactcctt gcatcaaggg gtcacttaca gaacaaagaa tcttttgggg gaaacttcct 3000 ctaaaaccct ctcatatata gacagctttg actggagggt ccatttttct tccaggatgg 3060 tgttactgca gttgaaaggg caatatgaag ttactttctt aatgtgacct agcaataggc 3120 atagctacgt ggcactatat tctggccaga ctcgatgtgt actctaactt aagaaataaa 3180 tcagtaaggc agaacaagaa aaaaaaaaaa aaaaaaa 3217 <210> 42 <211> 4840 <212> DNA <213> Homo sapiens transmembrane protein 48 (TMEM48) <400> 42 ctgcttctgg cgccccgctg gaccctgctt cgaagggacc gtttggtcgc cagagggcgg 60 ttcctggagt tacagccgcg tttgcgggac gtgtctgcgc ggcagtcctg gcctgttgag 120 cttgtccaga cgaagcctcg cagggatggg ttggagcctg ggccgggctt cgctcaggca 180 gcgtttgagg cagacccagc agggtcctcc tggggccttc ctgcctttga actgcggtgg 240 cgggcgggcg cacggtctcc tgtacgccct agactagggg ccgccatctc catggccacg 300 gccgtgagcc ggccctgcgc cggcaggtcg cgggacatac tgtggcgcgt tttgggctgg 360 aggatagttg caagtattgt ttggtcagtg ctatttctac ccatctgcac cacagtattt 420 ataattttca gcaggattga tttgtttcat cctatacagt ggctgtctga ttctttcagt 480 gacctgtata gttcctatgt aatcttttac ttcctgctgc tgtcagtggt aataataata 540 ataagtattt tcaatgtgga gttctatgca gttgtgcctt ctattccttg ctccagacta 600 gctctgatag ggaagatcat tcatcctcag caactcatgc actcatttat tcatgctgca 660 atgggaatgg tgatggcctg gtgtgctgca gtgataaccc agggccagta cagctttctt 720 gtggttccct gcactggtac taacagcttt ggtagccctg ctgcgcaaac ctgcttaaat 780 gaatatcatc tttttttcct actgactgga gcatttatgg gctatagcta tagcctcctg 840 tattttgtta acaacatgaa ctatcttcca tttcccatca tacagcaata caagttcttg 900 cgttttagga gatctctgct cttattagtt aaacacagtt gtgtggaatc actgttcctg 960 gttagaaatt tctgcatttt atattatttt cttggctata ttcccaaagc ttggattagc 1020 actgctatga accttcacat agatgagcag gttcataggc cacttgacac agtgagtggc 1080 ctcttaaatc tctcgttact ctaccatgtc tggctgtgtg gtgtctttct cctgacgact 1140 tggtatgtct catggatact cttcaaaatc tatgccacag aggctcatgt gtttcctgtt 1200 caaccaccat ttgcagaagg gtcagatgag tgccttccaa aagtgttaaa tagcaatcct 1260 ccccccatca taaagtattt agccttgcag gacctgatgt tgctttctca atattctcct 1320 tcacgaagac aagaagtttt cagcctcagc caaccaggtg gacatcccca caattggaca 1380 gccatttcaa gggagtgttt gaatctttta aatggtatga ctcagaaact gattctctat 1440 caagaagctg ctgctacgaa tgggagagtg tcttcatctt acccagtgga acctaagaaa 1500 ttaaattctc cagaagaaac tgcttttcag acaccaaaat ctagccagat gcctcggcct 1560 tcagtgccac cattagttaa aacatcactg ttttcttcaa aattatctac acctgatgtt 1620 gtgagcccat ttgggacccc atttggctct agtgtaatga atcggatggc tggaattttt 1680 gatgtaaaca cctgctatgg gtcaccgcaa agtcctcagc taataagaag ggggccaaga 1740 ttgtggacat cagcttctga tcagcaaatg actgaatttt ctaatccttc tccatctacc 1800 tctattagtg ctgagggtaa gacaatgaga caacccagtg tgatttattc atggattcag 1860 aataaacgtg aacagattaa gaatttcttg tcaaaacggg tgctgataat gtattttttc 1920 agtaagcacc cagaggcctc cattcaggct gttttttcag atgcccaaat gcatatttgg 1980 gcattagaag gtctgtcgca cttagtagca gcatcattta cagaggatag atttggagtt 2040 gtccagacga cactaccagc tatccttaat actttgttga cactgcaaga ggcagtcgac 2100 aagtacttta agcttcctca tgcttccagt aaaccacccc ggatttcagg aagccttgtg 2160 gacacttcat ataaaacatt aagatttgca ttcagagcat cactgaaaac tgccatctat 2220 cgaataacta ctacatttgg tgaacatctg aatgctgtgc aagcatctgc agaacatcag 2280 aaaagacttc aacagttctt ggagttcaaa gaatagttaa gtaatataaa ctgtgttcat 2340 tacactgctg atacaactac agatgggaca gtaaatgttc agcattcttg gatcagaaga 2400 aaacggacta attagatgct tcctttgtcg tggtggttgc tttgaaaact atactttaat 2460 gggagaaatc atggaaagaa attctcaaca gaataactga aaactgcctt ttctgtaccg 2520 attgcttttt gtgtgtgtgg tataataaaa tctttattca attttacaga agcattgatg 2580 gcagtcgaaa tgtctctagc tcatataact taatagtaat aactaaaaaa cttttagaat 2640 ttacttttga aaggagggaa gccagttctg aaatgagtat aggttgattt catagtcttc 2700 ttaattaaga gtttagctct ttgtaaactc aaaatacata aactttttaa gtgtagtttc 2760 atttactgaa ggataaaaat ggtaacagtg cagcaatatt cacaaaaaat attgtctaac 2820 ggacatattt tgttaatctg ttaggttggg tttttgtttc cagggacaaa ttaaatttgt 2880 atgattaccc aaaaaagggt ctcagtttac agatgctaac tctatataaa ggaatgtgga 2940 aaaactcagt tcttaagtta caagattaaa aattcacatt tggtctttaa gaaacaattg 3000 actgacatct atgaatttat tttgtatcat gctagtaaac acgaagtatt aatgtatggg 3060 tattttccca gctagttttg ctttcttttt ctggagcaaa acattaagtg attgcagagt 3120 ttttcaagca agagaaaaag gtttgcaaaa aaacccagga aatgttccct tttttcccca 3180 ccattcatct tcattagatc aaattctgtg aaacttgtct ggtctctcaa agggagcagc 3240 ctctgtagtg ttaaatggct aattaaaata ggaagatctt tatagccaga aacaacttag 3300 tcatcaaata gcaagtgaaa ccaaaacgtc agagggatta ctgtacttgg aagtatgttg 3360 tgtgtcccaa atgtgaacga agtattgtta gaatttatta gatcagcttc tttggagatc 3420 aaagattgga aatcctagtc atagatattc actggactgg ctttggactg aaatgctcct 3480 ttgtaattct tttcctattg tcttttcctt ctagtgtccc aaaatatttt ctttaaagtc 3540 agcacagtac tgtatatgaa tctttaatgt ggtatcatat atgtctactt ttgtctgatt 3600 catcgatgta ttatatcttt ataattgaat attttagctc cgggtcctgt tgccccttca 3660 agcagtacat gccaaattat aaataggtgc tactggcctt gagcatatca ctgtgggaca 3720 gttccccaat tgtcaagtgt ttagatatgt agactattgc catttgtttt tttgttttgg 3780 ttttgctttg tgtctgaagc tgaattgatt tctttttttt gaatgtgaaa gttgaatttc 3840 aaacgtagtc atttcttaca gatggccaag acagaaaatt gtggctaggt tgactgagaa 3900 ctgttgtctt ccatgtatta acacaattaa gctttttata ttccactctc tgtgctgacc 3960 ctggctgagg cattttggga gacaaggact ctgaatcttc tgcttccatt aaagaagaac 4020 tgtgatattc aacattggat ttctgagaat aaagatagga tgattccttt gaactttgac 4080 ttacttgtat aaaatgtcca gctaggttag gtttttgcca tttcctatat actttgggta 4140 aagctacatt tgatgagcaa tgtgaatgtt tctgagaatg ttcattcctg ttttctctta 4200 agagaatgtg ctgtgtacta aatacaggcc acatagtgtc tgcctgttga agatctggaa 4260 actgcctccc cagatctgta ttgtatttgg taggtaaggg ggtcagtttc tttttctcat 4320 tgtgtgttga taatctacac accatctgtt ggaaccaggg tgttattatg gggaactcct 4380 cctgtgtact aggaggagga ccttagggag accaagagga gagaagcatt tcctttgatg 4440 aagtcacatc ctgtctatga gcccactaat gctgtaacat tggcctgaaa gagagtgttc 4500 tttaaaagcc tttctcggct gttagtataa aaacatgatg gtatcagctc ttagcatgtt 4560 tgcttgaccc ttatggaagg tataaatcca cagaacttcc ttcccagaga actgggaaat 4620 tgtcctagaa ataaaccttg tacagttgag tggacatgga taagcaacaa tttgttactt 4680 tgcaggattt gttccttggt aattgtttgg tgtgtcatcc tgtaaatatt catgatagtc 4740 tgtttatatc cttttgtata tcgttgatac tggattgggt agaaaaataa attggcaatt 4800 taaaaaaatg gaacagttaa ttgaaaaaaa aaaaaaaaaa 4840 <210> 43 <211> 2811 <212> DNA <213> Homo sapiens cyclin A2 (CCNA2) <400> 43 ccatttcaat agtcgcggga tacttgaact gcaagaacag ccgccgctcc ggcgggctgc 60 tcgctgcatc tctgggcgtc tttggctcgc cacgctgggc agtgcctgcc tgcgcctttc 120 gcaacctcct cggccctgcg tggtctcgag ctgggtgagc gagcgggcgg gctggtaggc 180 tggcctgggc tgcgaccggc ggctacgact attctttggc cgggtcggtg cgagtggtcg 240 gctgggcaga gtgcacgctg cttggcgccg caggctgatc ccgccgtcca ctcccgggag 300 cagtgatgtt gggcaactct gcgccggggc ctgcgacccg cgaggcgggc tcggcgctgc 360 tagcattgca gcagacggcg ctccaagagg accaggagaa tatcaacccg gaaaaggcag 420 cgcccgtcca acaaccgcgg acccgggccg cgctggcggt actgaagtcc gggaacccgc 480 ggggtctagc gcagcagcag aggccgaaga cgagacgggt tgcacccctt aaggatcttc 540 ctgtaaatga tgagcatgtc accgttcctc cttggaaagc aaacagtaaa cagcctgcgt 600 tcaccattca tgtggatgaa gcagaaaaag aagctcagaa gaagccagct gaatctcaaa 660 aaatagagcg tgaagatgcc ctggctttta attcagccat tagtttacct ggacccagaa 720 aaccattggt ccctcttgat tatccaatgg atggtagttt tgagtcacca catactatgg 780 acatgtcaat tgtattagaa gatgaaaagc cagtgagtgt taatgaagta ccagactacc 840 atgaggatat tcacacatac cttagggaaa tggaggttaa atgtaaacct aaagtgggtt 900 acatgaagaa acagccagac atcactaaca gtatgagagc tatcctcgtg gactggttag 960 ttgaagtagg agaagaatat aaactacaga atgagaccct gcatttggct gtgaactaca 1020 ttgataggtt cctgtcttcc atgtcagtgc tgagaggaaa acttcagctt gtgggcactg 1080 ctgctatgct gttagcctca aagtttgaag aaatataccc cccagaagta gcagagtttg 1140 tgtacattac agatgatacc tacaccaaga aacaagttct gagaatggag catctagttt 1200 tgaaagtcct tacttttgac ttagctgctc caacagtaaa tcagtttctt acccaatact 1260 ttctgcatca gcagcctgca aactgcaaag ttgaaagttt agcaatgttt ttgggagaat 1320 taagtttgat agatgctgac ccatacctca agtatttgcc atcagttatt gctggagctg 1380 cctttcattt agcactctac acagtcacgg gacaaagctg gcctgaatca ttaatacgaa 1440 agactggata taccctggaa agtcttaagc cttgtctcat ggaccttcac cagacctacc 1500 tcaaagcacc acagcatgca caacagtcaa taagagaaaa gtacaaaaat tcaaagtatc 1560 atggtgtttc tctcctcaac ccaccagaga cactaaatct gtaacaatga aagactgcct 1620 ttgttttcta agatgtaaat cactcaaagt atatggtgta cagtttttaa cttaggtttt 1680 aattttacaa tcatttctga atacagaagt tgtggccaag tacaaattat ggtatctatt 1740 actttttaaa tggttttaat ttgtatatct tttgtatatg tatctgtctt agatatttgg 1800 ctaattttaa gtggttttgt taaagtatta atgatgccag ctgtcaggat aataaattga 1860 tttggaaaac tttgcaagtc aaatttaact tcttcaggat tttgcttagt aaagaagttt 1920 acttggttta ctatataatg ggaagtgaaa agccttcctc taaaattaaa gtaggtttag 1980 gaaaacagac cctcaaattc tgacattcat tttcctaagc aactggatca atttgctgac 2040 ttgggcataa tctaatctaa gcatatctga atacagtatt cagagataga tacagtagag 2100 attccccaga ctttttcgct ctttgtaaaa cctgtttgtt taggttttgc gaggtaaact 2160 caacagaggt tgggagtgga agagggtggg aagcttatat gcaaattaac agacgagaaa 2220 tgctccagaa ggtttattat tttaaagcac attaaaaaca aaaaactatt tttaaaatcc 2280 tgctagattt tataatggat ttgtgaataa aaaataccca gggttctcag aatggaataa 2340 atatcccttt taatagttat atatacagat atacaactgt tagctttaat tggcagctct 2400 cttctttttt cttcttttca ctggcttttt acttggtgct ttttcttgtt ttgcactggt 2460 ggtctgtgtt ctgtgaataa agcaaagtaa gaatttacta agagtatgtt aagttttgga 2520 ttattgaaat aagaggcatt tcttagtttt ccagtaggat ctaaaatgtg tcagctatga 2580 gtaagactgg catccaagaa gtttatatta tagatttagg tcctaatttt tataaatcac 2640 aaggtaaaaa aatcacagaa cagatggatc tctaatgaaa aagggatgtc tttttgttta 2700 tagtcatgtg gcaagatgag agtaaaacca gagagcaaac ctctataagt gttgagtata 2760 tgtatacatt tgaaataaac cagaaatttg ttaccttaaa aaaaaaaaaa a 2811 <210> 44 <211> 2265 <212> DNA <213> Homo sapiens flap structure-specific endonuclease 1 (FEN1) <400> 44 agtcctgcga tttcgggtgt agagggagca ggggcctgcg gggacctggt gtgggtggag 60 tggggacaag cggtggagaa gggtacgcca gggtcgctga gagactctgt tctccctgga 120 gggactggtt gccatgagag cagccgtctg aggggacgca gcctgcacta cgcgccccaa 180 gaggctgtgc gtggcgagca ggtcacgtga cgggagcgcg ggctttggaa ggcggctgaa 240 cgtcaggcca cccgccgcta agctgagaag ggagagcgag cttaggaccg cctgcccggg 300 gcaaccccga accaagcttt agccgccgag gccgcgtgtc ccaaaggcca gtcatccctc 360 ctctgtgttg ccatgggaat tcaaggcctg gccaaactaa ttgctgatgt ggcccccagt 420 gccatccggg agaatgacat caagagctac tttggccgta aggtggccat tgatgcctct 480 atgagcattt atcagttcct gattgctgtt cgccagggtg gggatgtgct gcagaatgag 540 gagggtgaga ccaccagcca cctgatgggc atgttctacc gcaccattcg catgatggag 600 aacggcatca agcccgtgta tgtctttgat ggcaagccgc cacagctcaa gtcaggcgag 660 ctggccaaac gcagtgagcg gcgggctgag gcagagaagc agctgcagca ggctcaggct 720 gctggggccg agcaggaggt ggaaaaattc actaagcggc tggtgaaggt cactaagcag 780 cacaatgatg agtgcaaaca tctgctgagc ctcatgggca tcccttatct tgatgcaccc 840 agtgaggcag aggccagctg tgctgccctg gtgaaggctg gcaaagtcta tgctgcggct 900 accgaggaca tggactgcct caccttcggc agccctgtgc taatgcgaca cctgactgcc 960 agtgaagcca aaaagctgcc aatccaggaa ttccacctga gccggattct gcaggagctg 1020 ggcctgaacc aggaacagtt tgtggatctg tgcatcctgc taggcagtga ctactgtgag 1080 agtatccggg gtattgggcc caagcgggct gtggacctca tccagaagca caagagcatc 1140 gaggagatcg tgcggcgact tgaccccaac aagtaccctg tgccagaaaa ttggctccac 1200 aaggaggctc accagctctt cttggaacct gaggtgctgg acccagagtc tgtggagctg 1260 aagtggagcg agccaaatga agaagagctg atcaagttca tgtgtggtga aaagcagttc 1320 tctgaggagc gaatccgcag tggggtcaag aggctgagta agagccgcca aggcagcacc 1380 cagggccgcc tggatgattt cttcaaggtg accggctcac tctcttcagc taagcgcaag 1440 gagccagaac ccaagggatc cactaagaag aaggcaaaga ctggggcagc agggaagttt 1500 aaaaggggaa aataaatgtg tttccccatt atacctcctt caccccagaa tatttgccgt 1560 cttgtaccct taagagctac agctagagaa accttcacgg ggtggagaga ggattctaag 1620 gcttttctag cgtgaccctt ttcagtagtg ctagtccctt ttttacttga tcttaatggc 1680 aagaaggcca cagaggtact tttccttttt tagctcagga aaatatgtca ggctcaaacc 1740 acttctcagg cagtttaatg gacactaagt ccattgttac atgaaagtga tagatagcaa 1800 caagttttgg agaagagaga gggagataaa agggggagac aaaagatgta cagaaatgat 1860 ttcctggctg gccaactggt ggccagtggg aggtgatggt ggacctagac tgtgcttttc 1920 tgtcttgttc agccttgacc caccttgaga gagagccacc aggaaggcgc atcttagcag 1980 atgggaggaa ctgctgagag aagatgggca gaaagctgga gcccctggag ttggctgtgt 2040 ctgtgtttgt gactgattac tggctgtgtc ttgggtgggc agaaactcga acttgctatg 2100 taatttgtgt ctagttattc agaggagtaa gatggtgatg ttcacctggc aatcagctga 2160 gttgagactt tggaataaga cactggtttt catgcgctgt ttttgtttta aagttatgaa 2220 gaaaaaagtc aataaaattc taaaagtaaa aaaaaaaaaa aaaaa 2265 <210> 45 <211> 627 <212> DNA <213> Homo sapiens CDC28 protein kinase regulatory subunit 2 (CKS2) <400> 45 agtctccggc gagttgttgc ctgggctgga cgtggttttg tctgctgcgc ccgctcttcg 60 cgctctcgtt tcattttctg cagcgcgcca cgaggatggc ccacaagcag atctactact 120 cggacaagta cttcgacgaa cactacgagt accggcatgt tatgttaccc agagaacttt 180 ccaaacaagt acctaaaact catctgatgt ctgaagagga gtggaggaga cttggtgtcc 240 aacagagtct aggctgggtt cattacatga ttcatgagcc agaaccacat attcttctct 300 ttagacgacc tcttccaaaa gatcaacaaa aatgaagttt atctggggat cgtcaaatct 360 ttttcaaatt taatgtatat gtgtatataa ggtagtattc agtgaatact tgagaaatgt 420 acaaatcttt catccatacc tgtgcatgag ctgtattctt cacagcaaca gagctcagtt 480 aaatgcaact gcaagtaggt tactgtaaga tgtttaagat aaaagttctt ccagtcagtt 540 tttctcttaa gtgcctgttt gagtttactg aaacagttta cttttgttca ataaagtttg 600 tatgttgcat ttaaaaaaaa aaaaaaa 627 <210> 46 <211> 3094 <212> DNA <213> Homo sapiens X-ray repair complementing defective repair in Chinese hamster cells2 (XRCC2) <400> 46 tttgactggc cgtagagtct gcgcagttgg tgaatggcgt tggtggcggg aaagttgagt 60 ctctcctgcg ccgagccttc ggggcgatgt gtagtgcctt ccatagggct gagtctggga 120 ccgagctcct tgcccgactt gaaggtagaa gttccttgaa agaaatagaa ccaaatctgt 180 ttgctgatga agattcacct gtgcatggtg atattcttga atttcatggc ccagaaggaa 240 caggaaaaac agaaatgctt tatcacctaa cagcacgatg tatacttccc aaatcagaag 300 gtggcctgga agtagaagtc ttatttattg atacagatta ccactttgat atgctccggc 360 tagttacaat tcttgagcac agactatccc aaagctctga agaaataatc aaatactgcc 420 tgggaagatt ttttttggtg tactgcagta gtagcaccca cttacttctt acactttact 480 cactagaaag tatgttttgt agtcacccat ctctctgcct tttgattttg gatagcctgt 540 cagcttttta ctggatagac cgcgtcaatg gaggagaaag tgtgaactta caggagtcta 600 ctctgaggaa atgttctcag tgcttagaga agcttgtaaa tgactatcgc ctggttcttt 660 ttgcaacgac acaaactata atgcagaaag cctcgagctc atcagaagaa ccttctcatg 720 cctctcgacg actgtgtgat gtggacatag actacagacc ttatctctgt aaggcatggc 780 agcaactggt gaagcacagg atgtttttct ccaaacaaga tgattctcaa agcagcaacc 840 aattttcatt agtttcacgt tgtttaaaaa gtaacagttt aaaaaaacat ttttttatta 900 ttggagaaag tggggttgaa ttttgttgat atacatcata aaatagtctt ttgcagggta 960 ctacgcaagc cttaaaattt ttcttaagac agagtcttgc tctgtctccc aggctggagt 1020 gcagtggcac aatcatggct cactgcagcc ttgaactcct ggcctcaagg gatcctccta 1080 tgtgtgcctc ctagagtgca gggattacag gcgtgagcca ctgctcgtgg ccaaaagttt 1140 tctttttttt tttttttctt tttgaaacag tcttactctg tctcccaggc tgctggagtg 1200 cagtggcaca atctcggccc gctgcagcct ctgcctcttg ggttcaagtg attcttccac 1260 ctcagcctcc caggtagctg ggattacagg cacccaccac cacgcctggc taatttttgt 1320 atttttaata gagacggggt ttcaccatgt tggccaggct ggtctcgaac tcctgacctc 1380 aagtgatcca cccacctcgg cctcccaaag tgctaggatt acaggcccgt gcccagccct 1440 aaagttttaa actctagggg aattaacagt atttctttac agaatggatt tgttaaacta 1500 gcacagtaaa agtaaagact attctgtttc taggctgttg aatcaaagtg attttagcaa 1560 ttaaactttg tattaattta ccaccaatat ttcttcacaa aggaactttt aaaagattat 1620 ctcagaaagt aaatctgaga ggtaagaagt aataatgagt aaatggtaag tacttgagta 1680 aatctaaaga aatattgata gtaaggcaat cctaagcaaa aagaacaaag ctggaggcat 1740 cacgctaccc agcttcaaac tatactacaa ggctacagta accaaaacag catagtactg 1800 gcacaaaaac acacgtagac tgatggaaca gaatagagaa tttagaaatg agaccacaca 1860 cctataattt ttttgatctt cgatgaacct gacaaaaaca agcaatgggc aatggattct 1920 ctattcaata aatcgtgctg ggataactgg ccagccatat ggaaaagatt gaaaatggac 1980 gccttcctta tgccatatac aaaaattaac tcaagatgga ttaaagactt aatgtaaaac 2040 ccaaaacagt aaaaatcctg gaagacaacc caggcagtac cattcaggac ataggcacag 2100 gcaaagattt catgacgaag acgccaaaaa caattgcaac agaagcaaaa attcacaaat 2160 gggatctaat taaactaaag agctgcacag caaaagaaac tatcaagaga gtaaacagac 2220 agcttacaga atgggagaaa attgttgcaa actatgcatc tgagaaaggt ctgaaatcca 2280 gcatctatac gtaatttaaa caaatttaga agaaaaaacc accccattaa aaagtgggca 2340 aaggacatga acagacactt ttcaaaagaa gacatctgtg gccaacaatc ctatggaaaa 2400 aagcccagca tcactgatca ttagagaaat gcaaatcgaa acaacaacga gataccatct 2460 cacaccagtc caaatggcta ttataaaaat gtcagaaaat aacagatgct ggtgaggttg 2520 tggagaaaaa gatatgctta tacactgttg gtggaaatgt aaattaaatt agttcagcca 2580 ttgtggaaga cagtgtgggg ataaagacag agataccatt caacccagca atctcattac 2640 tgggtatata cccaaaggaa tagaaatcat tgttataaag acacatgcac gcgtatgttc 2700 gttgcagcac tgcccatcag tgacagactg gattaaaaaa atgtggtaca tacacaccag 2760 ggaatactat acagccataa aaaggaacaa gactgactgg gcgtggtggc tcatgcctgt 2820 gatcctagca ctttgcgagg ccgaggtggg tggattgccc gcgctcagga ggtcaagacc 2880 agcctgggca acacggtgaa accccatctc tattaaaata caaaaaatta gctgggcatg 2940 gtggtgcgtg cctgtagtgc cagctactca ggaggccgag gcaggagaat tgctggaacc 3000 caggaggtgg aggttgcagt gagctgagat cgcgccattg cactcccgcc tgggcgactc 3060 catctctaaa aaaaaaaaaa aaaaaaaaaa aaaa 3094 <210> 47 <211> 3509 <212> DNA <213> Homo sapiens budding uninhibited by benzimidazoles 1 homolog (yeast) (BUB1) <400> 47 ggcgccctga aacgttcggc gagccgactg cggctgcgcg gggtattcga atcggcggcg 60 gcttctagtt tgcggttcag gtttggccgc tgccggccag cgtcctctgg ccatggacac 120 cccggaaaat gtccttcaga tgcttgaagc ccacatgcag agctacaagg gcaatgaccc 180 tcttggtgaa tgggaaagat acatacagtg ggtagaagag aattttcctg agaataaaga 240 atacttgata actttactag aacatttaat gaaggaattt ttagataaga agaaatacca 300 caatgaccca agattcatca gttattgttt aaaatttgct gagtacaaca gtgacctcca 360 tcaatttttt gagtttctgt acaaccatgg gattggaacc ctgtcatccc ctctgtacat 420 tgcctgggcg gggcatctgg aagcccaagg agagctgcag catgccagtg ctgtccttca 480 gagaggaatt caaaaccagg ctgaacccag agagttcctg caacaacaat acaggttatt 540 tcagacacgc ctcactgaaa cccatttgcc agctcaagct agaacctcag aacctctgca 600 taatgttcag gttttaaatc aaatgataac atcaaaatca aatccaggaa ataacatggc 660 ctgcatttct aagaatcagg gttcagagct ttctggagtg atatcttcag cttgtgataa 720 agagtcaaat atggaacgaa gagtgatcac gatttctaaa tcagaatatt ctgtgcactc 780 atctttggca tccaaagttg atgttgagca ggttgttatg tattgcaagg agaagcttat 840 tcgtggggaa tcagaatttt cctttgaaga attgagagcc cagaaataca atcaacggag 900 aaagcatgag caatgggtaa atgaagacag acattatatg aaaaggaaag aagcaaatgc 960 ttttgaagaa cagctattaa aacagaaaat ggatgaactt cataagaagt tgcatcaggt 1020 ggtggagaca tcccatgagg atctgcccgc ttcccaggaa aggtccgagg ttaatccagc 1080 acgtatgggg ccaagtgtag gctcccagca ggaactgaga gcgccatgtc ttccagtaac 1140 ctatcagcag acaccagtga acatggaaaa gaacccaaga gaggcacctc ctgttgttcc 1200 tcctttggca aatgctattt ctgcagcttt ggtgtcccca gccaccagcc agagcattgc 1260 tcctcctgtt cctttgaaag cccagacagt aacagactcc atgtttgcag tggccagcaa 1320 agatgctgga tgtgtgaata agagtactca tgaattcaag ccacagagtg gagcagagat 1380 caaagaaggg tgtgaaacac ataaggttgc caacacaagt tcttttcaca caactccaaa 1440 cacatcactg ggaatggttc aggcaacgcc atccaaagtg cagccatcac ccaccgtgca 1500 cacaaaagaa gcattaggtt tcatcatgaa tatgtttcag gctcctacac ttcctgatat 1560 ttctgatgac aaagatgaat ggcaatctct agatcaaaat gaagatgcat ttgaagccca 1620 gtttcaaaaa aatgtaaggt catctggggc ttggggagtc aataagatca tctcttcttt 1680 gtcatctgct tttcatgtgt ttgaagatgg aaacaaagaa aattatggat taccacagcc 1740 taaaaataaa cccacaggag ccaggacctt tggagaacgc tctgtcagca gacttccttc 1800 aaaaccaaag gaggaagtgc ctcatgctga agagtttttg gatgactcaa ctgtatgggg 1860 tattcgctgc aacaaaaccc tggcacccag tcctaagagc ccaggagact tcacatctgc 1920 tgcacaactt gcgtctacac cattccacaa gcttccagtg gagtcagtgc acattttaga 1980 agataaagaa aatgtggtag caaaacagtg tacccaggcg actttggatt cttgtgagga 2040 aaacatggtg gtgccttcaa gggatggaaa attcagtcca attcaagaga aaagcccaaa 2100 acaggccttg tcgtctcaca tgtattcagc atccttactt cgtctgagcc agcctgctgc 2160 aggtggggta cttacctgtg aggcagagtt gggcgttgag gcttgcagac tcacagacac 2220 tgacgctgcc attgcagaag atccaccaga tgctattgct gggctccaag cagaatggat 2280 gcagatgagt tcacttggga ctgttgatgc tccaaacttc attgttggga acccatggga 2340 tgataagctg attttcaaac ttttatctgg gctttctaaa ccagtgagtt cctatccaaa 2400 tacttttgaa tggcaatgta aacttccagc catcaagccc aagactgaat ttcaattggg 2460 ttctaagctg gtctatgtcc atcaccttct tggagaagga gcctttgccc aggtgtacga 2520 agctacccag ggagatctga atgatgctaa aaataaacag aaatttgttt taaaggtcca 2580 aaagcctgcc aacccctggg aattctacat tgggacccag ttgatggaaa gactaaagcc 2640 atctatgcag cacatgttta tgaagttcta ttctgcccac ttattccaga atggcagtgt 2700 attagtagga gagctctaca gctatggaac attattaaat gccattaacc tctataaaaa 2760 tacccctgaa aaagtgatgc ctcaaggtct tgtcatctct tttgctatga gaatgcttta 2820 catgattgag caagtgcatg actgtgaaat cattcatgga gacattaaac cagacaattt 2880 catacttgga aacggatttt tggaacagga tgatgaagat gatttatctg ctggcttggc 2940 actgattgac ctgggtcaga gtatagatat gaaacttttt ccaaaaggaa ctatattcac 3000 agcaaagtgt gaaacatctg gttttcagtg tgttgagatg ctcagcaaca aaccatggaa 3060 ctaccagatc gattactttg gggttgctgc aacagtatat tgcatgctct ttggcactta 3120 catgaaagtg aaaaatgaag gaggagagtg taagcctgaa ggtcttttta gaaggcttcc 3180 tcatttggat atgtggaatg aattttttca tgttatgttg aatattccag attgtcatca 3240 tcttccatct ttggatttgt taaggcaaaa gctgaagaaa gtatttcaac aacactatac 3300 taacaagatt agggccctac gtaataggct aattgtactg ctcttagaat gtaagcgttc 3360 acgaaaataa aatttggata tagacagtcc ttaaaaatca cactgtaaat atgaatctgc 3420 tcactttaaa cctgtttttt tttcatttat tgtttatgta aatgtttgtt aaaaataaat 3480 cccatggaat atttccatgt aaaaaaaaa 3509 <210> 48 <211> 4562 <212> DNA <213> Homo sapiens minichromosome maintenance complex component 10 (MCM10) <400> 48 ggttggaatt ttggcgggtt cagctgtgaa cgaagaaggc gtcccggcat cggccaagat 60 tctacattgc tcatctgggc atctgagcct ccttcgaagt ttcctgtcac aactgtcctc 120 ttgacagcat ggatgaggag gaagacaatc tgtctctgct gaccgcactg ctggaagaaa 180 atgagtcagc cttggattgt aattcagaag aaaataactt cttgacgcgg gaaaatggcg 240 agcccgacgc atttgatgag ctctttgatg ccgacggcga cggtgaatct tatacagaag 300 aggctgatga tggagaaaca ggagagacaa gagacgaaaa ggaaaatctg gccactctct 360 ttggagatat ggaggactta acagatgaag aagaagttcc cgcatcacag tcaactgaaa 420 atagggtcct ccctgctcct gcccccaggc gagagaaaac gaatgaagag ttgcaagagg 480 aattaaggaa tttgcaagag caaatgaagg ccttacaaga gcagctaaaa gtaacaacaa 540 ttaaacagac agcaagccca gcccgtctgc aaaaatcccc tgtagagaag tctccccggc 600 cacctcttaa ggagaggaga gttcagagaa ttcaggagtc aacatgcttt tctgcggagc 660 ttgatgtccc tgcgctacca agaaccaaga gggtggctcg aacaccaaag gcttcacctc 720 cagatcccaa aagctcatct tcaaggatga caagtgcacc ctcccaaccc ctacagacga 780 tttctcggaa caaacctagt gggataacta gaggtcaaat tgtggggacc ccaggaagtt 840 ctggggaaac gactcaaccc atctgtgtgg aagccttctc tggtctgcgg ctcaggcggc 900 ctcgagtatc ctccacagaa atgaacaaga aaatgaccgg ccgaaaactg atcagactgt 960 ctcagatcaa ggaaaagatg gccagagaga agctggaaga aatagattgg gtgacatttg 1020 gggttatatt gaagaaggtt acgccacaga gtgtgaatag tggaaaaacc ttcagcatat 1080 ggaaactgaa tgatcttcgt gacctgacac aatgtgtgtc cttgttctta tttggagaag 1140 ttcacaaagc gctctggaag acggagcagg ggactgtcgt agggatcctc aatgccaacc 1200 ccatgaagcc caaggatggt tcagaggagg tgtgtttatc tatcgatcat cctcagaagg 1260 tcttaattat gggtgaagct cttgacctgg gaacctgtaa agccaagaag aagaatggag 1320 agccgtgcac gcagactgtg aatttgcgtg actgtgagta ctgtcagtac catgtccagg 1380 ctcagtacaa gaagctcagc gcaaagcgtg cggatctgca gtccaccttc tctggaggac 1440 gaattccaaa gaagtttgcc cgcagaggca ccagcctcaa agaacggctg tgccaagatg 1500 gcttttacta cggaggggtt tcttctgcct cgtatgcagc ttcaattgca gcagctgtgg 1560 ctcctaagaa gaagattcaa accactctga gtaatctggt tgttaagggc acaaacttga 1620 tcatccagga aacacggcaa aaactcggaa taccccagaa gagcctgtct tgctctgagg 1680 agttcaagga actgatggac ctgccgacgt gtggagccag gaacttaaaa caacatttag 1740 ccaaagccac agcttcaggg attatgggga gcccaaaacc agccatcaag tccatctcgg 1800 cctcagcact cttgaagcaa cagaagcagc ggatgttgga gatgaggaga aggaaatcag 1860 aagaaataca gaagcgattt ctgcagagct caagtgaagt tgagagccca gctgtgccat 1920 cttcatcaag acagccccct gctcagcctc cacggacagg atccgagttc cccaggctgg 1980 agggagcccc ggccacaatg acgcccaagc tggggcgagg tgtcttggaa ggagatgatg 2040 ttctctttta tgatgagtca ccaccaccaa gaccaaaact gagtgcttta gcagaagcca 2100 aaaagttagc tgctatcacc aaattaaggg caaaaggcca ggttcttaca aaaacaaacc 2160 caaacagcat taagaagaaa caaaaggacc ctcaggacat cctggaggtg aaggaacgtg 2220 tagaaaaaaa caccatgttt tcttctcaag ctgaggatga attggagcct gccaggaaaa 2280 aaaggagaga acaacttgcc tatctggaat ctgaggaatt tcagaaaatc ctaaaagcaa 2340 aatcaaaaca cacaggcatc ctgaaagagg ccgaggctga gatgcaggag cgctactttg 2400 agccactggt gaaaaaagaa caaatggaag aaaagatgag aaacatcaga gaagtgaagt 2460 gccgtgtcgt gacatgcaag acgtgcgcct atacccactt caagctgctg gagacctgcg 2520 tcagtgagca gcatgaatac cactggcatg atggtgtgaa gaggtttttc aaatgtccct 2580 gtggaaacag aagcatctcc ttggacagac tcccgaacaa gcactgcagt aactgtggcc 2640 tctacaaatg ggaacgggac ggaatgctaa aggaaaagac tggtccaaag ataggaggag 2700 aaactctgtt accaagagga gaagaacatg ctaaatttct gaacagcctt aaataacccg 2760 aacttcagac attttcccac agacttcctg gcctcctgtg actctggaaa gcaaaggatt 2820 ggctgtgtat tgtccattga ttcctgattg acgccgtcaa aaacaaatgc ttgttaagcc 2880 cataagcttt gcctgcttac tttctgccat tgggttggtt tgataccaca tttaacattg 2940 acatttaagt ggaaaaccaa gttatcattg tcttttctaa gctcagtgtg gatgattgca 3000 ttacttcatt cactgaagtt tttgcccaaa aattggaagg taaacagaga gctatgtttc 3060 tgtatctttt ggttatagag tgttcacttc tttatcataa caaaattcta gtgtttatac 3120 gaacacccag aggcaaaaga atttggctta attctcactc caggtaagta gcttaacttc 3180 tgggcttcag ttttctcatc tgtaaaatca ggaagattgg actaagtgat cctgaaatgt 3240 attttttagc actggatttc tacaaataat aaaactttcc catctagata atgatgatca 3300 catagtcttg atgtacggac attaaaagcc agatttcttc attcaattct gttatctctg 3360 ttttactctt tgaaattgat caagccactg aatcactttg catttcagtt tatatatata 3420 gagagaaaga aggtgtctgc tcttacatta ttgtggagcc ctgtgataga aatatgtaaa 3480 atctcatatt attttttttt taattttttt attttttatg acagggtctc actatgtcac 3540 cctggctgga gtgcagtagt gcgatcgcgg cacactgcag ccttggcttc cctgggctca 3600 agcagtcctc ccacctcagt ctcccaaata gctaggacta caggcgtgcg tgaccaagcc 3660 cagctaattt ttgcattttt tgtagagatg gggttttgcc atgttgctca ggctggtctc 3720 aaactcctga gcactagcaa tccacccacc tctgtttcca aaaaaaaaaa aaaaatgaaa 3780 ggtcaacccc tatgcaaatt accacagcaa aggtttcatt caggagattc ttccatctgg 3840 gcaacctggt tttccaaata tcatttgacc taagtgaatg ttgatactag ctaaagattg 3900 ggtaaattgg ttgaattatt gtattgaagc ttgagctgta gctaaaagta atttaggttt 3960 cccctaagat gttattatgt tagggacata acacttttgg gaggttgttg tgggagatgg 4020 ttgatttagg ttttcaaaag ctagaaataa aatttacatg ccttagattt cataaaattc 4080 tgctctaatt gggtggaagg tgctgtatct aacttgtgtt cctcctaagg ttatgtccta 4140 ataactattc ttttaggagt atacttctac tttatagaag gttgcttttc tttttaattt 4200 tttctaacaa agaaaagaat aaagtattta ttaataagaa ccagaaagca cttgaaactg 4260 atgtttttaa tggctcattt agggtagatt tatttatctc attaacttaa aacagctatg 4320 tgtatgaaat aggtcacaac agaacttgaa caccaggttg gtgtctgagc aatccctttc 4380 ttatgggaaa aacaatgttc ttgtttgaac agagggtatc attgcagtca gtattcacgt 4440 gtatattgtt atataagttg tataatatgc ttgtaaaggc tgagggtgag ctgtatctgg 4500 atgccttttt acaatttgat tttaactttt aaaataaatt taaaacataa aaaaaaaaaa 4560 aa 4562 <210> 49 <211> 2204 <212> DNA <213> Homo sapiens polo-like kinase 1 (PLK1) <400> 49 gagcggtgcg gaggctctgc tcggatcgag gtctgcagcg cagcttcggg agcatgagtg 60 ctgcagtgac tgcagggaag ctggcacggg caccggccga ccctgggaaa gccggggtcc 120 ccggagttgc agctcccgga gctccggcgg cggctccacc ggcgaaagag atcccggagg 180 tcctagtgga cccacgcagc cggcggcgct atgtgcgggg ccgctttttg ggcaagggcg 240 gctttgccaa gtgcttcgag atctcggacg cggacaccaa ggaggtgttc gcgggcaaga 300 ttgtgcctaa gtctctgctg ctcaagccgc accagaggga gaagatgtcc atggaaatat 360 ccattcaccg cagcctcgcc caccagcacg tcgtaggatt ccacggcttt ttcgaggaca 420 acgacttcgt gttcgtggtg ttggagctct gccgccggag gtctctcctg gagctgcaca 480 agaggaggaa agccctgact gagcctgagg cccgatacta cctacggcaa attgtgcttg 540 gctgccagta cctgcaccga aaccgagtta ttcatcgaga cctcaagctg ggcaaccttt 600 tcctgaatga agatctggag gtgaaaatag gggattttgg actggcaacc aaagtcgaat 660 atgacgggga gaggaagaag accctgtgtg ggactcctaa ttacatagct cccgaggtgc 720 tgagcaagaa agggcacagt ttcgaggtgg atgtgtggtc cattgggtgt atcatgtata 780 ccttgttagt gggcaaacca ccttttgaga cttcttgcct aaaagagacc tacctccgga 840 tcaagaagaa tgaatacagt attcccaagc acatcaaccc cgtggccgcc tccctcatcc 900 agaagatgct tcagacagat cccactgccc gcccaaccat taacgagctg cttaatgacg 960 agttctttac ttctggctat atccctgccc gtctccccat cacctgcctg accattccac 1020 caaggttttc gattgctccc agcagcctgg accccagcaa ccggaagccc ctcacagtcc 1080 tcaataaagg cttggagaac cccctgcctg agcgtccccg ggaaaaagaa gaaccagtgg 1140 ttcgagagac aggtgaggtg gtcgactgcc acctcagtga catgctgcag cagctgcaca 1200 gtgtcaatgc ctccaagccc tcggagcgtg ggctggtcag gcaagaggag gctgaggatc 1260 ctgcctgcat ccccatcttc tgggtcagca agtgggtgga ctattcggac aagtacggcc 1320 ttgggtatca gctctgtgat aacagcgtgg gggtgctctt caatgactca acacgcctca 1380 tcctctacaa tgatggtgac agcctgcagt acatagagcg tgacggcact gagtcctacc 1440 tcaccgtgag ttcccatccc aactccttga tgaagaagat caccctcctt aaatatttcc 1500 gcaattacat gagcgagcac ttgctgaagg caggtgccaa catcacgccg cgcgaaggtg 1560 atgagctcgc ccggctgccc tacctacgga cctggttccg cacccgcagc gccatcatcc 1620 tgcacctcag caacggcagc gtgcagatca acttcttcca ggatcacacc aagctcatct 1680 tgtgcccact gatggcagcc gtgacctaca tcgacgagaa gcgggacttc cgcacatacc 1740 gcctgagtct cctggaggag tacggctgct gcaaggagct ggccagccgg ctccgctacg 1800 cccgcactat ggtggacaag ctgctgagct cacgctcggc cagcaaccgt ctcaaggcct 1860 cctaatagct gccctcccct ccggactggt gccctcctca ctcccacctg catctggggc 1920 ccatactggt tggctcccgc ggtgccatgt ctgcagtgtg ccccccagcc ccggtggctg 1980 ggcagagctg catcatcctt gcaggtgggg gttgctgtgt aagttatttt tgtacatgtt 2040 cgggtgtggg ttctacagcc ttgtccccct ccccctcaac cccaccatat gaattgtaca 2100 gaatatttct attgaattcg gaactgtcct ttccttggct ttatgcacat taaacagatg 2160 tgaatattca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa 2204 <210> 50 <211> 3685 <212> DNA <213> Homo sapiens TPX2, microtubule-associated, homolog (Xenopus laevis) (TPX2) <400> 50 agtggactca cgcaggcgca ggagactaca cttcccagga actccgggcc gcgttgttcg 60 ctggtacctc cttctgactt ccggtattgc tgcggtctgt agggccaatc gggagcctgg 120 aattgctttc ccggcgctct gattggtgca ttcgactagg ctgcctgggt tcaaaatttc 180 aacgatactg aatgagtccc gcggcgggtt ggctcgcgct tcgttgtcag atctgaggcg 240 aggctaggtg agccgtggga agaaaagagg gagcagctag ggcgcgggtc tccctcctcc 300 cggagtttgg aacggctgaa gttcaccttc cagcccctag cgccgttcgc gccgctaggc 360 ctggcttctg aggcggttgc ggtgctcggt cgccgcctag gcggggcagg gtgcgagcag 420 gggcttcggg ccacgcttct cttggcgaca ggattttgct gtgaagtccg tccgggaaac 480 ggaggaaaaa aagagttgcg ggaggctgtc ggctaataac ggttcttgat acatatttgc 540 cagacttcaa gatttcagaa aaggggtgaa agagaagatt gcaactttga gtcagacctg 600 taggcctgat agactgatta aaccacagaa ggtgacctgc tgagaaaagt ggtacaaata 660 ctgggaaaaa cctgctcttc tgcgttaagt gggagacaat gtcacaagtt aaaagctctt 720 attcctatga tgccccctcg gatttcatca atttttcatc cttggatgat gaaggagata 780 ctcaaaacat agattcatgg tttgaggaga aggccaattt ggagaataag ttactgggga 840 agaatggaac tggagggctt tttcagggca aaactccttt gagaaaggct aatcttcagc 900 aagctattgt cacacctttg aaaccagttg acaacactta ctacaaagag gcagaaaaag 960 aaaatcttgt ggaacaatcc attccgtcaa atgcttgttc ttccctggaa gttgaggcag 1020 ccatatcaag aaaaactcca gcccagcctc agagaagatc tcttaggctt tctgctcaga 1080 aggatttgga acagaaagaa aagcatcatg taaaaatgaa agccaagaga tgtgccactc 1140 ctgtaatcat cgatgaaatt ctaccctcta agaaaatgaa agtttctaac aacaaaaaga 1200 agccagagga agaaggcagt gctcatcaag atactgctga aaagaatgca tcttccccag 1260 agaaagccaa gggtagacat actgtgcctt gtatgccacc tgcaaagcag aagtttctaa 1320 aaagtactga ggagcaagag ctggagaaga gtatgaaaat gcagcaagag gtggtggaga 1380 tgcggaaaaa gaatgaagaa ttcaagaaac ttgctctggc tggaataggg caacctgtga 1440 agaaatcagt gagccaggtc accaaatcag ttgacttcca cttccgcaca gatgagcgaa 1500 tcaaacaaca tcctaagaac caggaggaat ataaggaagt gaactttaca tctgaactac 1560 gaaagcatcc ttcatctcct gcccgagtga ctaagggatg taccattgtt aagcctttca 1620 acctgtccca aggaaagaaa agaacatttg atgaaacagt ttctacatat gtgccccttg 1680 cacagcaagt tgaagacttc cataaacgaa cccctaacag atatcatttg aggagcaaga 1740 aggatgatat taacctgtta ccctccaaat cttctgtgac caagatttgc agagacccac 1800 agactcctgt actgcaaacc aaacaccgtg cacgggctgt gacctgcaaa agtacagcag 1860 agctggaggc tgaggagctc gagaaattgc aacaatacaa attcaaagca cgtgaacttg 1920 atcccagaat acttgaaggt gggcccatct tgcccaagaa accacctgtg aaaccaccca 1980 ccgagcctat tggctttgat ttggaaattg agaaaagaat ccaggagcga gaatcaaaga 2040 agaaaacaga ggatgaacac tttgaatttc attccagacc ttgccctact aagattttgg 2100 aagatgttgt gggtgttcct gaaaagaagg tacttccaat caccgtcccc aagtcaccag 2160 cctttgcatt gaagaacaga attcgaatgc ccaccaaaga agatgaggaa gaggacgaac 2220 cggtagtgat aaaagctcaa cctgtgccac attatggggt gccttttaag ccccaaatcc 2280 cagaggcaag aactgtggaa atatgccctt tctcgtttga ttctcgagac aaagaacgtc 2340 agttacagaa ggagaagaaa ataaaagaac tgcagaaagg ggaggtgccc aagttcaagg 2400 cacttccctt gcctcatttt gacaccatta acctgccaga gaagaaggta aagaatgtga 2460 cccagattga acctttctgc ttggagactg acagaagagg tgctctgaag gcacagactt 2520 ggaagcacca gctggaagaa gaactgagac agcagaaaga agcagcttgt ttcaaggctc 2580 gtccaaacac cgtcatctct caggagccct ttgttcccaa gaaagagaag aaatcagttg 2640 ctgagggcct ttctggttct ctagttcagg aaccttttca gctggctact gagaagagag 2700 ccaaagagcg gcaggagctg gagaagagaa tggctgaggt agaagcccag aaagcccagc 2760 agttggagga ggccagacta caggaggaag agcagaaaaa agaggagctg gccaggctac 2820 ggagagaact ggtgcataag gcaaatccaa tacgcaagta ccagggtctg gagataaagt 2880 caagtgacca gcctctgact gtgcctgtat ctcccaaatt ctccactcga ttccactgct 2940 aaactcagct gtgagctgcg gataccgccc ggcaatggga cctgctctta acctcaaacc 3000 taggaccgtc ttgctttgtc attgggcatg gagagaaccc atttctccag acttttacct 3060 acccgtgcct gagaaagcat acttgacaac tgtggactcc agttttgttg agaattgttt 3120 tcttacatta ctaaggctaa taatgagatg taactcatga atgtctcgat tagactccat 3180 gtagttactt cctttaaacc atcagccggc cttttatatg ggtcttcact ctgactagaa 3240 tttagtctct gtgtcagcac agtgtaatct ctattgctat tgccccttac gactctcacc 3300 ctctccccac tttttttaaa aattttaacc agaaaataaa gatagttaaa tcctaagata 3360 gagattaagt catggtttaa atgaggaaca atcagtaaat cagattctgt cctcttctct 3420 gcataccgtg aatttatagt taaggatccc tttgctgtga gggtagaaaa cctcaccaac 3480 tgcaccagtg aggaagaaga ctgcgtggat tcatggggag cctcacagca gccacgcagc 3540 aggctctggg tggggctgcc gttaaggcac gttctttcct tactggtgct gataacaaca 3600 gggaaccgtg cagtgtgcat tttaagacct ggcctggaat aaatacgttt tgtctttccc 3660 tcaaaaaaaa aaaaaaaaaa aaaaa 3685 <210> 51 <211> 5787 <212> DNA <213> Homo sapiens toll-like receptor 4 (TLR4) <400> 51 ctcttgctgt ttctttagcc actggtctgc aggcgttttc ttcttctaac ttcctctcct 60 gtgacaaaag agataactat tagagaaaca aaagtccaga atgctaaggt tgccgctttc 120 acttcctctc accctttagc ccagaactgc tttgaataca ccaattgctg tggggcggct 180 cgaggaagag aagacaccag tgcctcagaa actgctcggt cagacggtga tagcgagcca 240 cgcattcaca gggccactgc tgctcacaga agcagtgagg atgatgccag gatgatgtct 300 gcctcgcgcc tggctgggac tctgatccca gccatggcct tcctctcctg cgtgagacca 360 gaaagctggg agccctgcgt ggagacttgg ccctaaacca cacagaagag ctggcatgaa 420 acccagagct ttcagactcc ggagcctcag cccttcaccc cgattccatt gcttcttgct 480 aaatgctgcc gttttatcac ggaggtggtt cctaatatta cttatcaatg catggagctg 540 aatttctaca aaatccccga caacctcccc ttctcaacca agaacctgga cctgagcttt 600 aatcccctga ggcatttagg cagctatagc ttcttcagtt tcccagaact gcaggtgctg 660 gatttatcca ggtgtgaaat ccagacaatt gaagatgggg catatcagag cctaagccac 720 ctctctacct taatattgac aggaaacccc atccagagtt tagccctggg agccttttct 780 ggactatcaa gtttacagaa gctggtggct gtggagacaa atctagcatc tctagagaac 840 ttccccattg gacatctcaa aactttgaaa gaacttaatg tggctcacaa tcttatccaa 900 tctttcaaat tacctgagta tttttctaat ctgaccaatc tagagcactt ggacctttcc 960 agcaacaaga ttcaaagtat ttattgcaca gacttgcggg ttctacatca aatgccccta 1020 ctcaatctct ctttagacct gtccctgaac cctatgaact ttatccaacc aggtgcattt 1080 aaagaaatta ggcttcataa gctgacttta agaaataatt ttgatagttt aaatgtaatg 1140 aaaacttgta ttcaaggtct ggctggttta gaagtccatc gtttggttct gggagaattt 1200 agaaatgaag gaaacttgga aaagtttgac aaatctgctc tagagggcct gtgcaatttg 1260 accattgaag aattccgatt agcatactta gactactacc tcgatgatat tattgactta 1320 tttaattgtt tgacaaatgt ttcttcattt tccctggtga gtgtgactat tgaaagggta 1380 aaagactttt cttataattt cggatggcaa catttagaat tagttaactg taaatttgga 1440 cagtttccca cattgaaact caaatctctc aaaaggctta ctttcacttc caacaaaggt 1500 gggaatgctt tttcagaagt tgatctacca agccttgagt ttctagatct cagtagaaat 1560 ggcttgagtt tcaaaggttg ctgttctcaa agtgattttg ggacaaccag cctaaagtat 1620 ttagatctga gcttcaatgg tgttattacc atgagttcaa acttcttggg cttagaacaa 1680 ctagaacatc tggatttcca gcattccaat ttgaaacaaa tgagtgagtt ttcagtattc 1740 ctatcactca gaaacctcat ttaccttgac atttctcata ctcacaccag agttgctttc 1800 aatggcatct tcaatggctt gtccagtctc gaagtcttga aaatggctgg caattctttc 1860 caggaaaact tccttccaga tatcttcaca gagctgagaa acttgacctt cctggacctc 1920 tctcagtgtc aactggagca gttgtctcca acagcattta actcactctc cagtcttcag 1980 gtactaaata tgagccacaa caacttcttt tcattggata cgtttcctta taagtgtctg 2040 aactccctcc aggttcttga ttacagtctc aatcacataa tgacttccaa aaaacaggaa 2100 ctacagcatt ttccaagtag tctagctttc ttaaatctta ctcagaatga ctttgcttgt 2160 acttgtgaac accagagttt cctgcaatgg atcaaggacc agaggcagct cttggtggaa 2220 gttgaacgaa tggaatgtgc aacaccttca gataagcagg gcatgcctgt gctgagtttg 2280 aatatcacct gtcagatgaa taagaccatc attggtgtgt cggtcctcag tgtgcttgta 2340 gtatctgttg tagcagttct ggtctataag ttctattttc acctgatgct tcttgctggc 2400 tgcataaagt atggtagagg tgaaaacatc tatgatgcct ttgttatcta ctcaagccag 2460 gatgaggact gggtaaggaa tgagctagta aagaatttag aagaaggggt gcctccattt 2520 cagctctgcc ttcactacag agactttatt cccggtgtgg ccattgctgc caacatcatc 2580 catgaaggtt tccataaaag ccgaaaggtg attgttgtgg tgtcccagca cttcatccag 2640 agccgctggt gtatctttga atatgagatt gctcagacct ggcagtttct gagcagtcgt 2700 gctggtatca tcttcattgt cctgcagaag gtggagaaga ccctgctcag gcagcaggtg 2760 gagctgtacc gccttctcag caggaacact tacctggagt gggaggacag tgtcctgggg 2820 cggcacatct tctggagacg actcagaaaa gccctgctgg atggtaaatc atggaatcca 2880 gaaggaacag tgggtacagg atgcaattgg caggaagcaa catctatctg aagaggaaaa 2940 ataaaaacct cctgaggcat ttcttgccca gctgggtcca acacttgttc agttaataag 3000 tattaaatgc tgccacatgt caggccttat gctaagggtg agtaattcca tggtgcacta 3060 gatatgcagg gctgctaatc tcaaggagct tccagtgcag agggaataaa tgctagacta 3120 aaatacagag tcttccaggt gggcatttca accaactcag tcaaggaacc catgacaaag 3180 aaagtcattt caactcttac ctcatcaagt tgaataaaga cagagaaaac agaaagagac 3240 attgttcttt tcctgagtct tttgaatgga aattgtatta tgttatagcc atcataaaac 3300 cattttggta gttttgactg aactgggtgt tcactttttc ctttttgatt gaatacaatt 3360 taaattctac ttgatgactg cagtcgtcaa ggggctcctg atgcaagatg ccccttccat 3420 tttaagtctg tctccttaca gaggttaaag tctagtggct aattcctaag gaaacctgat 3480 taacacatgc tcacaaccat cctggtcatt ctcgagcatg ttctattttt taactaatca 3540 cccctgatat atttttattt ttatatatcc agttttcatt tttttacgtc ttgcctataa 3600 gctaatatca taaataaggt tgtttaagac gtgcttcaaa tatccatatt aaccactatt 3660 tttcaaggaa gtatggaaaa gtacactctg tcactttgtc actcgatgtc attccaaagt 3720 tattgcctac taagtaatga ctgtcatgaa agcagcattg aaataatttg tttaaagggg 3780 gcactctttt aaacgggaag aaaatttccg cttcctggtc ttatcatgga caatttgggc 3840 tagaggcagg aaggaagtgg gatgacctca ggaggtcacc ttttcttgat tccagaaaca 3900 tatgggctga taaacccggg gtgacctcat gaaatgagtt gcagcagaag tttatttttt 3960 tcagaacaag tgatgtttga tggacctctg aatctcttta gggagacaca gatggctggg 4020 atccctcccc tgtacccttc tcactgccag gagaactacg tgtgaaggta ttcaaggcag 4080 ggagtataca ttgctgtttc ctgttgggca atgctccttg accacatttt gggaagagtg 4140 gatgttatca ttgagaaaac aatgtgtctg gaattaatgg ggttcttata aagaaggttc 4200 ccagaaaaga atgttcatcc agcctcctca gaaacagaac attcaagaaa aggacaatca 4260 ggatgtcatc agggaaatga aaataaaaac cacaatgaga tatcacctta taccaggtag 4320 aatggctact ataaaaaaat gaagtgtcat caaggatata gagaaattgg aacccttctt 4380 cactgctgga gggaatggaa aatggtgtag ccgttatgaa aaacagtacg gaggtttctc 4440 aaaaattaaa aatagaactg ctatatgatc cagcaatctc acttctgtat atatacccaa 4500 aataattgaa atcagaattt caagaaaata tttacactcc catgttcatt gtggcactct 4560 tcacaatcac tgtttccaaa gttatggaaa caacccaaat ttccattgaa aaataaatgg 4620 acaaagaaaa tgtgcatata cgtacaatgg gatattattc agcctaaaaa aagggggaat 4680 cctgttattt atgacaacat gaataaaccc ggaggccatt atgctatgta aaatgagcaa 4740 gtaacagaaa gacaaatact gcctgatttc atttatatga ggttctaaaa tagtcaaact 4800 catagaagca gagaatagaa cagtggttcc tagggaaaag gaggaaggga gaaatgagga 4860 aatagggagt tgtctaattg gtataaaatt atagtatgca agatgaatta gctctaaaga 4920 tcagctgtat agcagagttc gtataatgaa caatactgta ttatgcactt aacattttgt 4980 taagagggta cctctcatgt taagtgttct taccatatac atatacacaa ggaagctttt 5040 ggaggtgatg gatatattta ttaccttgat tgtggtgatg gtttgacagg tatgtgacta 5100 tgtctaaact catcaaattg tatacattaa atatatgcag ttttataata tcaattatgt 5160 ctgaatgaag ctataaaaaa gaaaagacaa caaaattcag ttgtcaaaac tggaaatatg 5220 accacagtca gaagtgtttg ttactgagtg tttcagagtg tgtttggttt gagcaggtct 5280 agggtgattg aacatccctg ggtgtgtttc catgtctcat gtactagtga aagtagatgt 5340 gtgcatttgt gcacatatcc ctatgtatcc ctatcagggc tgtgtgtatt tgaaagtgtg 5400 tgtgtccgca tgatcatatc tgtatagaag agagtgtgat tatatttctt gaagaataca 5460 tccatttgaa atggatgtct atggctgttt gagatgagtt ctctactctt gtgcttgtac 5520 agtagtctcc ccttatccct tatgcttggt ggatacgttc ttagacccca agtggatctc 5580 tgagaccgca gatggtacca aacctcatat atgcaatatt ttttcctata cataaatacc 5640 taagataaag ttcatcttct gaattaggca cagtaagaga ttaacaataa ctaacaataa 5700 aattgaatag ttataataat atattgtaat aaaagttatg tgaatgtgat ctctttcttt 5760 ctctctctca aaaaaaaaaa aaaaaaa 5787 <210> 52 <211> 4527 <212> DNA <213> Homo sapiens macrophage expressed 1 (MPEG1) <400> 52 attttgtcat taaattagct taaagaggaa cttgtagctt ttagagaact catgagtttt 60 ccgcttcatc atctgcttct gttttctcca tcttagtttg cccaaagctt gctggccgct 120 gtgtagggct ggtgagtggc tggggctgtc tgagccatga acaacttcag ggccaccatc 180 ctcttctggg cagcggcagc atgggctaaa tcaggcaagc cttcgggaga gatggacgaa 240 gttggagttc aaaaatgcaa gaatgccttg aaactacctg tcctggaagt cctacctgga 300 gggggctggg acaatctgcg gaatgtggac atgggacgag ttatggaatt gacttactcc 360 aactgcagga caacagagga tggacagtat atcatccctg atgaaatctt caccattccc 420 cagaaacaga gcaacctgga gatgaactca gaaatcctgg aatcctgggc aaattaccag 480 agtagcacct cctactccat caacacagaa ctctctcttt tttccaaagt caatggcaag 540 ttttccactg agttccagag gatgaagacc ctccaagtga aggaccaagc tataactacc 600 cgagttcagg taagaaacct cgtctacaca gtcaaaatca acccaacttt agagctaagc 660 tcaggtttta ggaaggaact ccttgacatc tctgaccgtc tagagaacaa ccagacgagg 720 atggccacct acctggcaga actcctggtg ctcaactatg gcacccacgt caccaccagt 780 gtcgacgctg gggctgctct tattcaggag gaccacctca gggcctcctt cctccaagac 840 agccagagca gtcgtagtgc cgtgaccgcc tctgctggac ttgcctttca aaacaccgtg 900 aacttcaaat ttgaggaaaa ctatacctcg cagaatgtcc tcaccaagag ctacctctca 960 aaccgaacca actccagggt gcagagcatt ggaggggttc ctttttaccc aggcatcacc 1020 ctccaggcct ggcagcaggg tatcaccaac cacctggtgg ccatcgaccg ctctggcctg 1080 ccgctgcatt tcttcatcaa ccccaacatg ctacctgact tgccaggccc cctggtgaag 1140 aaggtgtcaa agacagtgga aactgctgtg aagcgctatt atacattcaa cacctaccct 1200 ggctgcacag atctcaattc tcccaacttc aattttcagg ccaacacgga tgatggctcc 1260 tgcgagggga aaatgaccaa cttctctttc ggtggggttt atcaggaatg cactcagctc 1320 tcagggaata gggatgtcct cctctgccaa aagttggagc agaagaatcc actcactggt 1380 gatttctcct gcccctctgg ctactccccg gtgcacctgt tatcccagat ccacgaggag 1440 ggttacaacc acctggagtg tcatcgaaag tgcactctcc tcgtcttctg caagaccgtg 1500 tgtgaagatg tgttccaggt ggcaaaagct gaatttaggg ctttttggtg tgtggccagc 1560 agccaagtac ctgaaaactc aggactgctt tttgggggcc tcttcagcag caagagcata 1620 aaccccatga caaatgcaca gtcatgccca gccggctact ttccactgag actctttgaa 1680 aacctcaagg tatgtgtttc tcaggactat gagttgggaa gcaggtttgc ggtccccttt 1740 ggcgggttct ttagctgcac agttgggaac cccctggtag atcctgctat atccagagat 1800 ttaggggcac cgtctctgaa aaagtgcccc gggggcttca gccagcaccc agccctcatc 1860 agcgatggat gccaagtgtc ctattgcgtc aaatccgggc tcttcacagg agggtccctg 1920 ccccctgcca ggctcccacc tttcacccgg ccacccctca tgagtcaggc tgccaccaat 1980 actgtcatag tgaccaattc tgagaatgcg agatcctgga ttaaagactc ccagacccac 2040 cagtggaggc tgggagaacc gatagagctg cggagggcca tgaatgtcat ccatggggat 2100 ggtggtggtc tgtcaggagg ggctgcagct ggggtcacag tgggggtcac caccattctg 2160 gctgttgtta tcaccttggc catctacggc acccggaagt tcaagaagaa agcatatcag 2220 gcaattgagg aaaggcagag tttggttcca ggcactgcag caactggaga caccacttac 2280 caagagcagg ggcagagtcc agcttaaatc tctccccgaa aatggtttct ctcatctcca 2340 gtgtggtcat tgctgaccac tctgttttcc taagcattga aatggcaagt gcaaccaaaa 2400 gtaggtatat tcgtgacttc ttgtttaggt ctctgggcca ggaaattcat actgttacat 2460 ggataaggtt gggattgggg agagggaaca gttgggacta gaagcaaaag tgattctggg 2520 actaaaatag gaagcagatg tcctttccca atgtgtgttg ctgtcttcac ctgaatgcat 2580 ttgtgtaaaa atagcggagg gacaatgtga acatttgtat ttggaagcta tgaatttact 2640 ctgaagtttg cagttgtttc caatttgtga gctctaagag tttctgcctg taagaactac 2700 tctcctttta ttttgatttt taaaaacctg tctgaatttc acactcttag agcctggaag 2760 agccctgaaa agacacaagt cttgcctggc tactgctttt taactttgag ggctctatgt 2820 tgacagactg ttatctcctc tgggtgacct caaacatctg aaaagaaaga tgttgcctgt 2880 gccaattcca ctttttccag ctgccccttg atgaacactc ccttatacca gaccactctt 2940 ggacttctga ctggtgtcat caagtcctca gaaaatattt taagttattt taagttatta 3000 aggaagggat gatttggaga caaggagtaa tgaaagatgg gtaaaaactg gaaaagattc 3060 tggtgctaag tactacccct tcatcttcca tggatggtca ttacctttcc tgtcctcctg 3120 ttatatgaac acacacacac acacacacac acacacacac acacacgcac acacatacca 3180 catttcaata agtcttcatt gttctgggtc cttacctttc ctgtcctcct gttatatgaa 3240 cacacacaca cacacacaca cacacacaca cgcacaccac atttcaatgt ctgcatggtt 3300 ctgggggtaa caaaggcaag aagttaaagt aagaccacat ttgagtatta cttactctgt 3360 agaatcaaaa cagagtagtt aacaccaatt atgcaaacta cttttttttc cagcagaaag 3420 ggagctgaca tgatcaaatc catgttttca aatgaactga aaaaggcatc cagcaccact 3480 tataacacat ttatttcagt tccaggctga cagccctggg gcatctagca ggatgcataa 3540 ttgtcatctg gtgagagttg ggactttgct caattttaat accaatctct cctgattgta 3600 attacctcca ctactttcat gatcccccta caatattttt ttaaatgata tatttattca 3660 ctgaatcaaa tgtcattaat gagttatctt ctgtggagga tgactgttct ctttgttaat 3720 gttcacaatc aagatcttgg gctgagaaga ggcccttcac ccaaggagtt tgaagtatca 3780 cagtgtgtgg gaaggtggga accaggatac ccattcattt ccaaccgaga cacagagaag 3840 tgagtcacag aatttgagcc cgctctcttg actgcccagc cagagacact gatttctgta 3900 acctcttcac ttgatcctgc ctcttaagca ttaaaacatt ctcctaaacc tctgagtgtt 3960 ttgtgggttc tgggtgtttt gtacatttta gccaagctaa ccacttgtct gcaagtactg 4020 actttcctat gaattctttg aagattattg agtcagaaag gaaaaatata gccccaaatt 4080 cccaggcttt taatgcatta cattaactgc ctattgaaat gagaagttct tcacaaactt 4140 gtatacccac taacaagatt gcacataaac atgcattaaa gtatatacta agaaaccctc 4200 tgtccaacgg ctcatgcata tgaagtccga acatgggagt ttgccaattg cattcatcaa 4260 gtcgttttgc ggagtcagat ccctgatgga agagctcaca ggctctgcct tccaagtcct 4320 gggttcctaa ctggtgacct tagcctgggg tctgtgggga gaccaaccct ggcttccaag 4380 aaaaccacat tccatggact atcagaaata gacacagatt tgggtgacaa agctggctct 4440 gtatttgcat tttatttttg tgttcttgtc agtttgggaa tgattaatat taaacattta 4500 tttgagaaac aaaaaaaaaa aaaaaaa 4527 <210> 53 <211> 2885 <212> DNA <213> Homo sapiens lymphoid-restricted membrane protein (LRMP) <400> 53 agaagccatt aaacaactac aggaagatgc tgtcaaccag gaaggcatcc ttaggaagag 60 gctccaagaa accagccaac ggctggagga tgtggaggag caggtagggt ggctcatggc 120 tacattagat tcaggggaca tctcctcaga tgccctgcaa accatgaaat aaaaatggag 180 gaggaacaac aacaacaaac aaaaaaaaaa agcaaagagg aactgcaagt tcagtcccta 240 gcgactaaca gtgagcagag gaagtaaagg gggagttgta agagaggcgg tatcaacagc 300 ctgctgatga aagaggcgac tctgcagaaa gaggcaactt gacatatcag gactttaacc 360 gctgtagaaa tagctcaggc ataccaagcc catgcaaaca cagaattgca gaagttcagg 420 agaggcttat cacttccctg agaagaaaaa cacattttca gttttgcctg catcataaga 480 gtgagcactc cattgctttc tttcctggcc acactgctac aatccagcac taactatcca 540 tgtccagggt aaggatcgag atcgagaagc ccacactgcc agtgaaaaag ctacgtcttt 600 actgcataaa ttagaggaag caatttcgga acaacggaac cttcaaacta taaatactga 660 attatcgaac acttgccagg cacttcagca gaagacaagg aaactgaaga agctttttag 720 atgaggaatt tcctcactat gattccctgt cctgcgcaga tgcaattcaa caacctcttc 780 aagaaaaatt gaagcagtgt tgccacaaac tatatggtgg tcaagaagca agaatacatc 840 agacacccct gaccttgaaa catacgtgct ggtacacacc tctgctggat gccttatctc 900 tggatagttt tacagcagtt ccaaccctgg aatcaacacc tttctcaggt gtagccaacc 960 aaatccacac tctgtgtgaa aggcccacat atggagaagt aaaggatggt gctttggatg 1020 taaaaagaca acacaagtgc ccaggcccca caagtggccc cagcccagga acgaatctct 1080 caggctgcat caggatgaat gatgacccaa gtatggaaga gaatggtgtt gaacgcgtgt 1140 gtcctgagag cctgctgcag tccagggaat attcctcact accattaccc agacacactt 1200 catcgacaga cggtactata acttcaagtg atcctggatt agaaattctg aatatggctt 1260 cttgtgacct tgacagaaac tcgctctgta agaaagagga ggatacaaga tcagcttctc 1320 ccacgataga ggcccaaggc acaagtccag ctcatgataa tattgcattc caagactcta 1380 cgagtaagga taaaaccata ttaaatctgg aagccaaaga ggaaccagaa acaatagaag 1440 aacataaaaa agaacatgct tcaggagact ctgtggtttc ccctcttcct gtaaccactg 1500 tgaaatcggt taaccttaga caaagtgaga acacttctgc taatgagaag gaggtggagg 1560 cagaatttct cagattatct ttgggattta agtgtgactg gtttaccttg gagaagagag 1620 tgaagcttga agagaggtcc cgtgacttgg cagaagaaaa tttgaagaaa gaaatcacta 1680 actgtttaaa actattagag tctttaacac ctctgtgtga agatgacaac caggcacagg 1740 aaatcattaa gaagctggag aagagtataa agtttcttag ccagtgtgca gcacgagtgg 1800 ccagtagggc tgagatgttg ggagccatca atcaggaaag ccgggttagt aaagcagttg 1860 aagtgatgat tcagcacgta gaaaacttga agaggatgta tgccaaagag cacgctgaat 1920 tagaagaact gaaacaggtt cttctgcaga atgaaaggtc tttcaatcct cttgaagatg 1980 atgatgactg ccaaattaaa aaacgttcag cttctctaaa ctccaagcca tcttctctac 2040 gaagagtgac tattgcctct ttacccagaa atattggaaa tgcaggaatg gtggctggga 2100 tggaaaataa tgatcgattc agtagaaggt caagcagttg gcgtattttg gggtcaaagc 2160 agagtgaaca ccgtccctca ttacctcgat ttattagcac ctattcctgg gcagatgctg 2220 aagaagaaaa atgtgaacta aaaactaaag atgactcaga gccatctgga gaagaaacag 2280 tagaaaggac aaggaagcca agtctttctg aaaagaaaaa taatccatca aagtgggatg 2340 tctcttcagt ttatgacaca atagcttcct gggcaacaaa tctcaagtcc tccatcagaa 2400 aggctaataa ggccctctgg ctctctattg cattcattgt actgtttgca gctttgatga 2460 gcttcctcac aggccaatta ttccagaagt ctgtggatgc cgctcccaca cagcaagagg 2520 actcatggac gtctctagaa catatcttgt ggccatttac cagactccga cacaatgggc 2580 caccaccagt gtgacagcag gacatcctaa tatatggatc ttgattttta agtttcagta 2640 tctgaacttc gtaaattagt aacttttagc tgggaaagta tagcatgaaa ccagaggttc 2700 tcagaatgac tgtaagatag cttacatttc ctctttttgc ctttatctcc ccaactaaaa 2760 tacaatgggg aagaagtctg cctatgatct ttgaatgagc tttttaagga agaaatatta 2820 tatattgttt gttaaagttt attgaaataa agaatcattt aaatcttcaa aaaaaaaaaa 2880 aaaaa 2885 <210> 54 <211> 1564 <212> DNA <213> Homo sapiens membrane-spanning 4-domains, subfamily A, member 6A (MS4A6A) <400> 54 ttttactgaa gttgctagaa gtttacagaa aaggaagtgc aggaacattt cacaaatcta 60 caatctgtga gtatcacatc ctgtatagct gtaaacactg gaataaggaa gggctgatga 120 ctttcagaag atgaaggtaa gtagaaaccg ttgatgggac tgagaaacca gagttaaaac 180 ctctttggag cttctgagga ctcagctgga accaacgggc acagttggca acaccatcat 240 gacatcacaa cctgttccca atgagaccat catagtgctc ccatcaaatg tcatcaactt 300 ctcccaagca gagaaacccg aacccaccaa ccaggggcag gatagcctga agaaacatct 360 acacgcagaa atcaaagtta ttgggactat ccagatcttg tgtggcatga tggtattgag 420 cttggggatc attttggcat ctgcttcctt ctctccaaat tttacccaag tgacttctac 480 actgttgaac tctgcttacc cattcatagg accctttttt tttatcatct ctggctctct 540 atcaatcgcc acagagaaaa ggttaaccaa gcttttggtg catagcagcc tggttggaag 600 cattctgagt gctctgtctg ccctggtggg tttcattatc ctgtctgtca aacaggccac 660 cttaaatcct gcctcactgc agtgtgagtt ggacaaaaat aatataccaa caagaagtta 720 tgtttcttac ttttatcatg attcacttta taccacggac tgctatacag ccaaagccag 780 tctggctgga actctctctc tgatgctgat ttgcactctg ctggaattct gcctagctgt 840 gctcactgct gtgctgcggt ggaaacaggc ttactctgac ttccctggga gtgtactttt 900 cctgcctcac agttacattg gtaattctgg catgtcctca aaaatgactc atgactgtgg 960 atatgaagaa ctattgactt cttaagaaaa aagggagaaa tattaatcag aaagttgatt 1020 cttatgataa tatggaaaag ttaaccatta tagaaaagca aagcttgagt ttcctaaatg 1080 taagctttta aagtaatgaa cattaaaaaa aaccattatt tcactgtcat ttaagatatg 1140 tgttcattgg ggatctcttg atttgcctga cattgacttc agcaaaagca cggggctgta 1200 aattaccatt tactagatta gccaaatagt ctgaatttcc agaaaacaag gcagaatgat 1260 cattcccaga aacatttccc agaaaatgtt tcccagaaaa ctagacagca tgatcattca 1320 atggatcaca gtgaagcaaa ggacacaact ttttattgta ccccttaatt gtcaacagga 1380 gttaactgat ttgttgtggt gctcagactt ttttatacag gtgctagtgt tttatcctat 1440 gtattttaac tcattagtgc ataaaggcaa gccccatata atgaagtctc agggtatatg 1500 aaagtagctg gcttcaaaat aaaatttttg agtgcaaaaa aaaaaaaaaa aaaaaaaaaa 1560 aaaa 1564 <210> 55 <211> 1983 <212> DNA <213> Homo sapiens GTPase, IMAP family member 4 (GIMAP4) <400> 55 gtttctcaac atcctggctt agtattgtgt gcaaaatcag agaggggtgc aagatcctga 60 tttttcagga gttcaagcga caatggcagc ccaatacggc agtatgagct tcaaccccag 120 cacaccaggg gccagttatg ggcctggaag gcaagagccc agaaattccc aattgagaat 180 tgtgttagtg ggtaaaaccg gagcaggaaa aagtgcaaca ggaaacagca tccttggccg 240 gaaagtgttt cattctggca ctgcagcaaa atccattacc aagaagtgtg agaaacgcag 300 cagctcatgg aaggaaacag aacttgtcgt agttgacaca ccaggcattt tcgacacaga 360 ggtgcccaat gctgaaacgt ccaaggagat tattcgctgc attcttctga cctccccagg 420 gcctcatgct ctgcttctgg tggttccact gggccgttac actgaggaag agcacaaagc 480 cacagagaag atcctgaaaa tgtttggaga gagggctaga agtttcatga ttctcatatt 540 cacccggaaa gatgacttag gtgacaccaa tttgcatgac tacttaaggg aagctccaga 600 agacattcaa gacttgatgg acattttcgg tgaccgctac tgtgcgttaa acaacaaggc 660 aacaggcgct gagcaggagg cccagagggc acagttgctg ggcctgatcc agcgcgtggt 720 gagggagaac aaggaaggct gctacactaa taggatgtac caaagggcgg aggaggagat 780 ccagaagcaa acacaagcaa tgcaagaact ccacagagtg gagctggaga gagagaaagc 840 gcggataaga gaggagtatg aagagaaaat cagaaagctg gaagataaag tggagcagga 900 aaagagaaag aagcaaatgg agaagaaact agcagaacag gaggctcact atgctgtaag 960 gcagcaaagg gcaagaacgg aagtggagag taaggatggg atacttgaat taatcatgac 1020 agcgttacag attgcttcct ttattttgtt acgtctgttc gcggaagatt aaacttaatg 1080 aaaatctgtt tgtattttct gcatattctc tggcaacctt gccccatact tacttattta 1140 gcatagtcga gtgctctagt ttctgtctct caggcactcg taactaagga ccaccattgg 1200 ccattggtag atgtttgatt gacttaacaa gagagggaca aattttcaat ttgtgaaact 1260 ccaaagcaga aagtattggt gcttgctacc ttgtgaattc ttccttagac atgcagagaa 1320 aatgtatgca agagaccaaa aagatggctc caagctatgt catgttacct gtaataaaat 1380 cttttcttct agattctttc tatgttggca gataatctcc ccttgtagct tccactcact 1440 tattcttgca ttcagagtca caatgatcat cttacccatg tggtttttga gaaagaaaga 1500 tcaattcttt gtttgcagta ggtaatctta gagatggaga tgattgtaga attattccta 1560 gatgagtgtc aatttattta attccattgt catataagga gtcaaattgt ttcttatcat 1620 ttgttcattg aagaacagag acctgtctgg aaaatcgatc tctacaaatt caattaaata 1680 atgatcccca aatgctgaaa aagtgaaata cagcaattca acagataata gagcaatgtt 1740 tagtatattc agctgtatct gtagaaactc tttgacgaac ctcaatttaa ccaatttgat 1800 gaatacccag ttctcttctt ttctagagaa agatagttgc aacctcacct ccctcactca 1860 acactttgaa tacttattgt ttggcaggtc atccacacac ttctgccccc actgcattga 1920 attttttgct tatgttgttt ataataaaac ttttcaatta tctcaaaaaa aaaaaaaaaa 1980 aaa 1983 <210> 56 <211> 6117 <212> DNA <213> Homo sapiens dedicator of cytokinesis 2 (DOCK2) <400> 56 aggaaggaag tggggccctg cggcgcccag ccaccccctg acggcttccc cacgggagga 60 cgcgaggccc cggcccagcc atggccccct ggcgcaaagc tgacaaggag cggcacggcg 120 tggccatata caacttccaa ggcagcggag ccccccagct ctccctgcag atcggcgatg 180 tggtgcgaat acaggagacg tgtggagact ggtatagggg atacctcata aagcacaaaa 240 tgttacaggg catttttcct aagtcattta tccacatcaa ggaagtgaca gttgagaaaa 300 gaagaaatac tgagaacatc attcctgcag aaattcctct ggcacaagaa gtgacaacga 360 cactttggga atggggaagc atctggaaac aactctatgt ggccagcaaa aaggagcgtt 420 ttctccaggt gcagtccatg atgtacgatc tgatggagtg gaggtcccag cttctctcag 480 gaaccttacc caaggatgag ctgaaggaac tgaagcagaa agtcacgtcc aaaattgact 540 atggcaacaa aatccttgag cttgatttga ttgtcagaga tgaagacgga aatatcttgg 600 accctgataa taccagtgtc atcagcttgt tccatgcaca tgaggaagca actgataaaa 660 tcacagagcg tatcaaagaa gaaatgtcaa aagaccagcc agattatgca atgtattccc 720 ggatctcctc atcccccacc catagcctct atgtgtttgt gagaaacttt gtgtgcagaa 780 ttggggaaga tgctgagctc ttcatgtctc tctacgaccc caacaagcaa acggtcataa 840 gtgagaacta cctagtgcga tggggcagcc ggggcttccc taaggagatt gagatgctca 900 acaatctgaa ggtggtcttc acggatcttg gaaacaaaga cctcaacagg gataaaattt 960 acttgatttg tcaaatagtc cgggtcggca agatggatct taaggatact ggtgcaaaga 1020 agtgcacgca gggactgagg aggccctttg gggtggcagt tatggatata acagacatca 1080 tcaaggggaa agcagagagt gatgaagaaa agcagcactt cattcctttt cacccggtta 1140 cagctgagaa tgacttccta cacagcctgc tgggcaaagt catagcctcc aagggggaca 1200 gtggagggca aggcctctgg gtgaccatga agatgctggt gggtgacatc attcagattc 1260 gcaaggacta tccacacctg gtggacagga ccaccgtggt ggccaggaag ctgggattcc 1320 cagagatcat catgccaggg gatgtcagga acgacatcta cattactctc ttacaaggtg 1380 actttgacaa gtacaacaag accacacaga ggaatgtgga agtcatcatg tgtgtgtgcg 1440 cggaggatgg caaaacgctg cctaatgcaa tttgcgtggg agcaggggac aagcccatga 1500 atgagtatcg ctccgttgtg tactatcaag tcaaacagcc acgctggatg gaaacagtca 1560 aggtggctgt ccctattgaa gacatgcaga ggatccatct gcgattcatg tttcgacatc 1620 ggtcatctct ggaatctaaa gataaaggag aaaagaactt tgccatgtcc tatgtgaagc 1680 tgatgaaaga agatgggact actctacacg atggattcca tgacttagtt gtcctcaagg 1740 gggacagcaa gaagatggag gatgccagcg catacctgac ccttccttct tatcgacacc 1800 atgtggaaaa caagggggcc acgctgagca ggagctccag cagtgttggg gggctttctg 1860 tcagctcccg ggatgtgttc tccatttcca ccctggtgtg ctccacaaag ctcactcaga 1920 atgtgggctt gctgggtttg ctgaagtggc gtatgaagcc tcaactgcta caggagaatt 1980 tagaaaagtt gaagattgtg gatggagagg aagtggtgaa gtttctccag gatactctgg 2040 atgccctctt caacatcatg atggagcatt ctcaaagtga tgaatatgac atcctcgtct 2100 ttgatgcctt gatttacata ataggactca ttgcagaccg gaaatttcag catttcaaca 2160 ccgttctgga ggcttacatc caacagcatt tcagtgcgac cttggcttac aagaaattga 2220 tgacagtgct gaagacttac ttggatacct ccagcagagg ggagcaatgt gagccaatcc 2280 taagaacgct gaaggctttg gaatatgtgt tcaagttcat tgttcggtcg aggacattat 2340 tttcacagct ttatgaaggc aaagaacaga tggagtttga agaatccatg agacggctct 2400 ttgaatccat caacaatctg atgaaaagtc aatacaaaac taccatcctt ttgcaggtgg 2460 cggctttgaa atacatccca tctgtcctgc atgatgtaga aatggtcttt gatgcgaagt 2520 tactcagcca actcctgtat gagttctaca cctgcatccc tcctgtgaaa ctccagaagc 2580 agaaagtaca gtctatgaat gagatagtcc agagcaacct ctttaaaaag caagaatgcc 2640 gggacattct gcttcctgtc atcaccaaag agctgaagga gctgctggag cagaaggatg 2700 acatgcaaca ccaggtcctg gagaggaagt actgcgttga attgctcaac agcatcttgg 2760 aagtccttag ctaccaggat gcggccttca cctaccacca tatccaggag atcatggtcc 2820 agctgctgcg gacagtgaac cggacagtca tcaccatggg ccgggatcac attctgatta 2880 gtcactttgt ggcatgtatg acagccatct taaaccagat gggtgaccag cactactcct 2940 tctacattga gaccttccag accagctctg aacttgtgga cttcttgatg gagaccttca 3000 tcatgttcaa ggacctcatt ggaaagaacg tgtaccctgg agactggatg gccatgagca 3060 tggttcaaaa cagggtcttc ctgagagcta tcaacaagtt tgcagaaacc atgaaccaga 3120 agttcctaga acacacgaac tttgagttcc agctgtggaa caactatttt catctggcag 3180 tggcttttat cacccaggat tctctgcagc tggagcagtt ctcacacgcc aaatacaaca 3240 aaatcctgaa taagtatggg gacatgagac ggctaattgg cttctccatc cgtgatatgt 3300 ggtacaagct tggtcagaac aaaatctgct tcatcccagg catggtagga cctatattag 3360 agatgacact tatccctgag gctgagctcc ggaaagccac cataccaatc ttcttcgaca 3420 tgatgctgtg tgaatatcaa agaagtgggg atttcaaaaa gtttgaaaac gaaatcatcc 3480 tgaagctgga ccacgaggta gaagggggcc gaggcgacga gcagtacatg cagctcctgg 3540 agtcaatcct gatggaatgt gctgcagagc acccaaccat tgccaagtcg gtggagaact 3600 tcgtgaacct ggtcaaaggc ctcctggaga agctgctgga ttaccggggt gtgatgacag 3660 atgagagcaa agacaaccgc atgagctgca ccgtgaacct gctgaatttc tacaaagata 3720 acaacaggga ggagatgtac ataaggtacc tgtacaaact ccgcgatctt cacctggact 3780 gtgacaatta cacagaggct gcctacacgc tccttctcca cacctggctt ctcaagtggt 3840 cggatgagca gtgtgcatca caggtcatgc agacaggcca gcagcacccc cagacacacc 3900 ggcagctgaa ggagacgctc tacgagacca tcataggcta ctttgacaaa ggaaagatgt 3960 gggaagaggc cataagtctg tgcaaggagc tggcggaaca gtacgagatg gagatctttg 4020 actatgagct gctcagccag aacctgatcc agcaggcaaa attctatgaa agcatcatga 4080 aaatcctcag gcccaaacca gactactttg ctgttggata ctacggccag ggattcccct 4140 ccttcctgcg gaacaaagtg ttcatctacc gcgggaagga atatgagcga agagaagatt 4200 tccagatgca gctgatgacc cagttcccca atgcagagaa gatgaacacc acctctgccc 4260 cgggagatga tgtgaagaat gccccaggcc agtatatcca gtgcttcact gtccagcctg 4320 tcttggatga acatcccagg ttcaagaata agccagtgcc tgaccagatt ataaacttct 4380 acaaatccaa ctacgtgcaa aggttccact actcccggcc cgtgcgcagg gggaccgtag 4440 acccagagaa tgagtttgct tccatgtgga ttgagagaac ctccttcgtg actgcataca 4500 agctgccggg gatcctgcgc tggtttgagg tggtgcacat gtcgcagacc acaattagtc 4560 ctctggagaa tgccatagaa accatgtcca cggccaatga gaagatcctg atgatgataa 4620 accagtacca gagtgatgag accctcccca tcaacccact ctccatgctc ctgaacggga 4680 ttgtggaccc tgctgtcatg ggaggcttcg ccaagtatga gaaggccttc ttcactgaag 4740 agtatgtcag ggaccaccct gaggaccagg acaagctgac ccacctcaag gacctgattg 4800 catggcagat ccccttcttg ggagctggga ttaagatcca tgagaaaagg gtgtcagata 4860 acttgcgacc cttccatgac cggatggagg aatgtttcaa gaacctgaaa atgaaggtgg 4920 agaaggagta cggtgtccga gagatgcctg actttgacga caggagagtg ggccgtccca 4980 ggtctatgct gcgctcatac agacagatgt ccatcatctc tctggcttcc atgaattctg 5040 actgcagcac ccccagcaag cctacctcag agagctttga cctggaatta gcatcaccca 5100 agacgccgag agtggagcag gaggaaccga tctccccggg gagcaccctg cctgaggtca 5160 agctgcggag gtccaagaag aggacaaaga gaagcagcgt agtttttgcg gatgagaaag 5220 cagctgcaga gtcggacctg aagcggcttt ccaggaagca tgagttcatg agtgacacca 5280 acctctcgga gcatgcggcc atccccctca aggcgtctgt cctctctcaa atgagctttg 5340 ccagccagtc catgcctacc atcccagccc tggcgctctc agtggcaggc atccctgggt 5400 tggatgaggc caacacatct ccccgcctca gccagacctt cctccaactc tcagatggtg 5460 acaagaagac actcacacgg aagaaggtca atcagttctt caagacaatg ctggccagca 5520 aatcggctga agaaggcaaa cagatcccag actcgctgtc cacggacctg tgagctgctg 5580 ctgactaggg ctgcatggga gagccaggga ggggagtttc tggaagagga aagccatgcg 5640 tggaacatcg aagcctcaga gagtgggaga ctgtccccat cagttgtcct tacttagagg 5700 agacagagag gccaatcagg tcccagagct tgaatgctaa caagcccagc atcccctggg 5760 gctgtgatca tggtggatga ggaagcctca acgtagattc ctgaactcaa ggtaccagca 5820 agaatgcctt ctcccagtgt gctctcccca acatcctagg cacagctttc ataacccagt 5880 ttcttaggtg taagaaactg tttttatctc atttattaag tctcagaact taacagaaaa 5940 ggaagccttt taaatattct ttttaatttt attttagatt aacagttttg tactttacat 6000 ttttttatac aaccaaccag tttcttttct agccaatcat ctctgaagag ttgctgtttc 6060 ttactgacaa taaaaaatgt tctcttggtt cgaataaaaa aaaaaaaaaa aaaaaaa 6117 <210> 57 <211> 1957 <212> DNA <213> Homo sapiens adhesion molecule, interacts with CXADR antigen 1 (AMICA1) <400> 57 ctgtttgcat ctctgcaacc acttcagaag gcacgtgttt ggtttgctct gagcctaacc 60 tagagtgctc gcagcagtct ttcagttgag cttggggact gcagctgtgg ggagatttca 120 gtgcattgcc tcccctgggt gctcttcatc ttggatttga aagttgagag cagcatgttt 180 tgcccactga aactcatcct gctgccagtg ttactggatt attccttggg cctgaatgac 240 ttgaatgttt ccccgcctga gctaacagtc catgtgggtg attcagctct gatgggatgt 300 gttttccaga gcacagaaga caaatgtata ttcaagatag actggactct gtcaccagga 360 gagcacgcca aggacgaata tgtgctatac tattactcca atctcagtgt gcctattggg 420 cgcttccaga accgcgtaca cttgatgggg gacatcttat gcaatgatgg ctctctcctg 480 ctccaagatg tgcaagaggc tgaccaggga acctatatct gtgaaatccg cctcaaaggg 540 gagagccagg tgttcaagaa ggcggtggta ctgcatgtgc ttccagagga gcccaaagag 600 ctcatggtcc atgtgggtgg attgattcag atgggatgtg ttttccagag cacagaagtg 660 aaacacgtga ccaaggtaga atggatattt tcaggacggc gcgcaaagga ggagattgta 720 tttcgttact accacaaact caggatgtct gtggagtact cccagagctg gggccacttc 780 cagaatcgtg tgaacctggt gggggacatt ttccgcaatg acggttccat catgcttcaa 840 ggagtgaggg agtcagatgg aggaaactac acctgcagta tccacctagg gaacctggtg 900 ttcaagaaaa ccattgtgct gcatgtcagc ccggaagagc ctcgaacact ggtgaccccg 960 gcagccctga ggcctctggt cttgggtggt aatcagttgg tgatcattgt gggaattgtc 1020 tgtgccacaa tcctgctgct ccctgttctg atattgatcg tgaagaagac ctgtggaaat 1080 aagagttcag tgaattctac agtcttggtg aagaacacga agaagactaa tccagagata 1140 aaagaaaaac cctgccattt tgaaagatgt gaaggggaga aacacattta ctccccaata 1200 attgtacggg aggtgatcga ggaagaagaa ccaagtgaaa aatcagaggc cacctacatg 1260 accatgcacc cagtttggcc ttctctgagg tcagatcgga acaactcact tgaaaaaaag 1320 tcaggtgggg gaatgccaaa aacacagcaa gccttttgag aagaatggag agtcccttca 1380 tctcagcagc ggtggagact ctctcctgtg tgtgtcctgg gccactctac cagtgatttc 1440 agactcccgc tctcccagct gtcctcctgt ctcattgttt ggtcaataca ctgaagatgg 1500 agaatttgga gcctggcaga gagactggac agctctggag gaacaggcct gctgagggga 1560 ggggagcatg gacttggcct ctggagtggg acactggccc tgggaaccag gctgagctga 1620 gtggcctcaa accccccgtt ggatcagacc ctcctgtggg cagggttctt agtggatgag 1680 ttactgggaa gaatcagaga taaaaaccaa cccaaatcat tcctctggca cattatttct 1740 aaataagtgt tgtttgtgga aatcgtccta tttttatgcc tcggttgagg gggcaagtaa 1800 agtcctggtg aggaatttac agttagaaac ttttggaaaa actgaagttc ctggaggaaa 1860 gccaaaccgt gctaacacac tagaggctgg ttttggtcct gggaaaggtt tggggtgaat 1920 gggttggaag tagggtatga atacagtttt gggattt 1957 <210> 58 <211> 1774 <212> DNA <213> Homo sapiens Rho GTPase activating protein 15 (ARHGAP15) <400> 58 agtactgaaa ttaagcagca tccaacacag gcctactctt acgacatgtg actttactgt 60 tttccgtttt tgttgaaaga gtcattaaca gttaggagtt gatggcagtt tcaataacag 120 gtcattgccg agaaaaggat agcactataa tatgcagaaa tctacaaatt ctgatacttc 180 cgtggaaaca ctgaattcta cccgccaagg cacaggagct gtgcaaatga gaatcaaaaa 240 tgccaacagc caccatgaca ggctcagcca aagtaaatcc atgatcctca ccgatgtcgg 300 gaaggtcact gaacctatat ccagacacag aaggaatcat tcacagcata tcttgaaaga 360 tgtcattcct ccattggaac aactgatggt tgaaaaagaa ggttatctgc aaaaagctaa 420 aattgcagat ggaggaaaga aactaaggaa aaactggtct acttcctgga ttgttctttc 480 tagtcgaaga attgaatttt acaaagaatc caagcaacag gctctgtcca atatgaaaac 540 tgggcacaaa ccagaaagtg tggatttgtg tggagcacac attgaatggg ccaaggaaaa 600 atcgagcaga aagaatgtct ttcagatcac aacagtatca ggaaatgagt tccttctaca 660 gtcagatatt gacttcatca tattggattg gttccacgct atcaaaaatg caattgacag 720 attgccaaag gattcaagtt gtccatcaag aaacctggaa ttattcaaaa tccaaagatc 780 ctctagcact gaattgctaa gtcactacga cagtgatata aaagaacaga aaccagagca 840 cagaaaatct ttaatgttca gactgcatca cagtgcttcc gatacaagcg acaaaaatcg 900 agttaaaagc agattaaaga agtttattac ccgaagacct tccctgaaaa ctctgcaaga 960 aaaaggactt attaaagatc aaatttttgg ctctcatctg cacaaagtgt gtgaacgtga 1020 aaattccaca gttccgtggt ttgtaaagca atgcattgaa gctgttgaga aaagaggtct 1080 agatgttgat ggaatatatc gagttagtgg caatctggca acaatacaga agttaagatt 1140 tattgtcaac caagaagaga agctgaattt ggacgacagc cagtgggagg acatccacgt 1200 tgtcaccgga gcactgaaga tgtttttccg ggagctgcct gagccgctct tcccttacag 1260 tttctttgag cagtttgtgg aagcgatcaa aaagcaagac aacaacacaa gaattgaagc 1320 tgtaaaatct cttgtacaaa aactccctcc gccaaatcgt gacaccatga aagtcctctt 1380 tggacatcta actaagatag tggccaaagc ctccaagaac ctcatgtcca cgcaaagctt 1440 ggggattgta tttggaccta cccttctgcg agctgaaaat gaaacaggaa acatggcgat 1500 ccacatggtc taccagaacc agatagctga gctcatgctg agtgagtaca gtaagatctt 1560 cggctcagag gaagactgac agacaagaca agctactgaa tacgttcaca tctgtcttga 1620 tgcctaatat ttttacattt ctgtaaacat atttctgaaa tattttttgc ctttcaagcg 1680 acagatgcct cattttgtga aaacttaatg atgattttgt gtttaagttc caaacatttg 1740 aataaaataa ttgacaataa aaaaaaaaaa aaaa 1774 <210> 59 <211> 6082 <212> DNA <213> Homo sapiens integrin, alpha 4 (ITGA4) <400> 59 ataacgtctt tgtcactaaa atgttcccca ggggccttcg gcgagtcttt ttgtttggtt 60 ttttgttttt aatctgtggc tcttgataat ttatctagtg gttgcctaca cctgaaaaac 120 aagacacagt gtttaactat caacgaaaga actggacggc tccccgccgc agtcccactc 180 cccgagtttg tggctggcat ttgggccacg ccgggctggg cggtcacagc gaggggcgcg 240 cagtttgggg tcacacagct ccgcttctag gccccaacca ccgttaaaag gggaagcccg 300 tgccccatca ggtccgctct tgctgagccc agagccatcc cgcgctctgc gggctgggag 360 gcccgggcca ggacgcgagt cctgcgcagc cgaggttccc cagcgccccc tgcagccgcg 420 cgtaggcaga gacggagccc ggccctgcgc ctccgcacca cgcccgggac cccacccagc 480 ggcccgtacc cggagaagca gcgcgagcac ccgaagctcc cggctggcgg cagaaaccgg 540 gagtggggcc gggcgagtgc gcggcatccc aggccggccc gaacgctccg cccgcggtgg 600 gccgacttcc cctcctcttc cctctctcct tcctttagcc cgctggcgcc ggacacgctg 660 cgcctcatct cttggggcgt tcttccccgt tggccaaccg tcgcatcccg tgcaactttg 720 gggtagtggc cgtttagtgt tgaatgttcc ccaccgagag cgcatggctt gggaagcgag 780 gcgcgaaccc ggcccccgaa gggccgccgt ccgggagacg gtgatgctgt tgctgtgcct 840 gggggtcccg accggccgcc cctacaacgt ggacactgag agcgcgctgc tttaccaggg 900 cccccacaac acgctgttcg gctactcggt cgtgctgcac agccacgggg cgaaccgatg 960 gctcctagtg ggtgcgccca ctgccaactg gctcgccaac gcttcagtga tcaatcccgg 1020 ggcgatttac agatgcagga tcggaaagaa tcccggccag acgtgcgaac agctccagct 1080 gggtagccct aatggagaac cttgtggaaa gacttgtttg gaagagagag acaatcagtg 1140 gttgggggtc acactttcca gacagccagg agaaaatgga tccatcgtga cttgtgggca 1200 tagatggaaa aatatatttt acataaagaa tgaaaataag ctccccactg gtggttgcta 1260 tggagtgccc cctgatttac gaacagaact gagtaaaaga atagctccgt gttatcaaga 1320 ttatgtgaaa aaatttggag aaaattttgc atcatgtcaa gctggaatat ccagttttta 1380 cacaaaggat ttaattgtga tgggggcccc aggatcatct tactggactg gctctctttt 1440 tgtctacaat ataactacaa ataaatacaa ggctttttta gacaaacaaa atcaagtaaa 1500 atttggaagt tatttaggat attcagtcgg agctggtcat tttcggagcc agcatactac 1560 cgaagtagtc ggaggagctc ctcaacatga gcagattggt aaggcatata tattcagcat 1620 tgatgaaaaa gaactaaata tcttacatga aatgaaaggt aaaaagcttg gatcgtactt 1680 tggagcttct gtctgtgctg tggacctcaa tgcagatggc ttctcagatc tgctcgtggg 1740 agcacccatg cagagcacca tcagagagga aggaagagtg tttgtgtaca tcaactctgg 1800 ctcgggagca gtaatgaatg caatggaaac aaacctcgtt ggaagtgaca aatatgctgc 1860 aagatttggg gaatctatag ttaatcttgg cgacattgac aatgatggct ttgaagatgt 1920 tgctatcgga gctccacaag aagatgactt gcaaggtgct atttatattt acaatggccg 1980 tgcagatggg atctcgtcaa ccttctcaca gagaattgaa ggacttcaga tcagcaaatc 2040 gttaagtatg tttggacagt ctatatcagg acaaattgat gcagataata atggctatgt 2100 agatgtagca gttggtgctt ttcggtctga ttctgctgtc ttgctaagga caagacctgt 2160 agtaattgtt gacgcttctt taagccaccc tgagtcagta aatagaacga aatttgactg 2220 tgttgaaaat ggatggcctt ctgtgtgcat agatctaaca ctttgtttct catataaggg 2280 caaggaagtt ccaggttaca ttgttttgtt ttataacatg agtttggatg tgaacagaaa 2340 ggcagagtct ccaccaagat tctatttctc ttctaatgga acttctgacg tgattacagg 2400 aagcatacag gtgtccagca gagaagctaa ctgtagaaca catcaagcat ttatgcggaa 2460 agatgtgcgg gacatcctca ccccaattca gattgaagct gcttaccacc ttggtcctca 2520 tgtcatcagt aaacgaagta cagaggaatt cccaccactt cagccaattc ttcagcagaa 2580 gaaagaaaaa gacataatga aaaaaacaat aaactttgca aggttttgtg cccatgaaaa 2640 ttgttctgct gatttacagg tttctgcaaa gattgggttt ttgaagcccc atgaaaataa 2700 aacatatctt gctgttggga gtatgaagac attgatgttg aatgtgtcct tgtttaatgc 2760 tggagatgat gcatatgaaa cgactctaca tgtcaaacta cccgtgggtc tttatttcat 2820 taagatttta gagctggaag agaagcaaat aaactgtgaa gtcacagata actctggcgt 2880 ggtacaactt gactgcagta ttggctatat atatgtagat catctctcaa ggatagatat 2940 tagctttctc ctggatgtga gctcactcag cagagcggaa gaggacctca gtatcacagt 3000 gcatgctacc tgtgaaaatg aagaggaaat ggacaatcta aagcacagca gagtgactgt 3060 agcaatacct ttaaaatatg aggttaagct gactgttcat gggtttgtaa acccaacttc 3120 atttgtgtat ggatcaaatg atgaaaatga gcctgaaacg tgcatggtgg agaaaatgaa 3180 cttaactttc catgttatca acactggcaa tagtatggct cccaatgtta gtgtggaaat 3240 aatggtacca aattctttta gcccccaaac tgataagctg ttcaacattt tggatgtcca 3300 gactactact ggagaatgcc actttgaaaa ttatcaaaga gtgtgtgcat tagagcagca 3360 aaagagtgca atgcagacct tgaaaggcat agtccggttc ttgtccaaga ctgataagag 3420 gctattgtac tgcataaaag ctgatccaca ttgtttaaat ttcttgtgta attttgggaa 3480 aatggaaagt ggaaaagaag ccagtgttca tatccaactg gaaggccggc catccatttt 3540 agaaatggat gagacttcag cactcaagtt tgaaataaga gcaacaggtt ttccagagcc 3600 aaatccaaga gtaattgaac taaacaagga tgagaatgtt gcgcatgttc tactggaagg 3660 actacatcat caaagaccca aacgttattt caccatagtg attatttcaa gtagcttgct 3720 acttggactt attgtacttc tgttgatctc atatgttatg tggaaggctg gcttctttaa 3780 aagacaatac aaatctatcc tacaagaaga aaacagaaga gacagttgga gttatatcaa 3840 cagtaaaagc aatgatgatt aaggacttct ttcaaattga gagaatggaa aacagactca 3900 ggttgtagta aagaaattta aaagacactg tttacaagaa aaaatgaatt ttgtttggac 3960 ttcttttact catgatcttg tgacatatta tgtcttcatg caaggggaaa atctcagcaa 4020 tgattactct ttgagataga agaactgcaa aggtaataat acagccaaag ataatctctc 4080 agcttttaaa tgggtagaga aacactaaag cattcaattt attcaagaaa agtaagccct 4140 tgaagatatc ttgaaatgaa agtataactg agttaaatta tactggagaa gtcttagact 4200 tgaaatacta cttaccatat gtgcttgcct cagtaaaatg aaccccactg ggtgggcaga 4260 ggttcatttc aaatacatct ttgatacttg ttcaaaatat gttctttaaa aatataattt 4320 tttagagagc tgttcccaaa ttttctaacg agtggaccat tatcacttta aagcccttta 4380 tttataatac atttcctacg ggctgtgttc caacaaccat tttttttcag cagactatga 4440 atattatagt attataggcc aaactggcaa acttcagact gaacatgtac actggtttga 4500 gcttagtgaa attacttctg gataattatt tttttataat tatggatttc accatctttc 4560 tttctgtata tatacatgtg tttttatgta ggtatatatt taccattctt cctatctatt 4620 cttcctataa cacaccttta tcaagcatac ccaggagtaa tcttcaaatc ttttgttata 4680 ttctgaaaca aaagattgtg agtgttgcac tttacctgat acacgctgat ttagaaaata 4740 cagaaaccat acctcactaa taactttaaa atcaaagctg tgcaaagact agggggccta 4800 tacttcatat gtattatgta ctatgtaaaa tattgactat cacacaacta tttccttgga 4860 tgtaattctt tgttaccctt tacaagtata agtgttacct tacatggaaa cgaagaaaca 4920 aaattcataa atttaaattc ataaatttag ctgaaagata ctgattcaat ttgtatacag 4980 tgaatataaa tgagacgaca gcaaaatttt catgaaatgt aaaatatttt tatagtttgt 5040 tcatactata tgaggttcta ttttaaatga ctttctggat tttaaaaaat ttctttaaat 5100 acaatcattt ttgtaatatt tattttatgc ttatgatcta gataattgca gaatatcatt 5160 ttatctgact ctgccttcat aagagagctg tggccgaatt ttgaacatct gttataggga 5220 gtgatcaaat tagaaggcaa tgtggaaaaa caattctggg aaagatttct ttatatgaag 5280 tccctgccac tagccagcca tcctaattga tgaaagttat ctgttcacag gcctgcagtg 5340 atggtgagga atgttctgag atttgcgaag gcatttgagt agtgaaatgt aagcacaaaa 5400 cctcctgaac ccagagtgtg tatacacagg aataaacttt atgacattta tgtattttta 5460 aaaaactttg tatcgttata aaaaggctag tcattctttc aggagaacat ctaggatcat 5520 agatgaaaaa tcaagccccg atttagaact gtcttctcca ggatggtctc taaggaaatt 5580 tacatttggt tctttcctac tcagaactac tcagaaacaa ctatatattt caggttatct 5640 gagcacagtg aaagcagagt actatggttg tccaacacag gcctctcaga tacaagggga 5700 acacaattac atattgggct agattttgcc cagttcaaaa tagtatttgt tatcaactta 5760 ctttgttact tgtatcatga attttaaaac cctaccactt taagaagaca gggatgggtt 5820 attctttttt ggcaggtagg ctatataact atgtgatttt gaaatttaac tgctctggat 5880 tagggagcag tgaatcaagg cagacttatg aaatctgtat tatatttgta acagaatata 5940 ggaaatttaa cataattgat gagctcaaat cctgaaaaat gaaagaatcc aaattatttc 6000 agaattatct aggttaaata ttgatgtatt atgatggttg caaagttttt ttgtgtgtcc 6060 aataaacaca ttgtaaaaaa aa 6082 <210> 60 <211> 5379 <212> DNA <213> Homo sapiens phosphoinositide-3-kinase, catalytic, gamma polypeptide (PIK3CG) <400> 60 gcacttcctt ctcggctaga ttatctgaaa ctgttgtcgg ttcttgagat gatactacca 60 ccgaatgtct gtgtttcatt gtctagtcca acctgtattg tggatatcta caacgttccg 120 gcaatagttt tgcaggtgca tcacattttt gtttttgttt tgggaggaaa agggagggca 180 cggcagccag gcttcatatt cctacaagtg catgcttcaa gattactgta cttacagtgt 240 ttccaacatc ttctcataaa aggggaaagc ttcatagcct caaccatgaa ggaaaccagt 300 cgcatagggc atggagctgg agaactataa acagcccgtg gtgctgagag aggacaactg 360 ccgaaggcgc cggaggatga agccgcgcag tgctgcggcc agcctgtcct ccatggagct 420 catccccatc gagttcgtgc tgcccaccag ccagcgcaaa tgcaagagcc ccgaaacggc 480 gctgctgcac gtggccggcc acggcaacgt ggagcagatg aaggcccagg tgtggctgcg 540 agcgctggag accagcgtgg cggcggactt ctaccaccgg ctgggaccgc atcacttcct 600 cctgctctat cagaagaagg ggcagtggta cgagatctac gacaagtacc aggtggtgca 660 gactctggac tgcctgcgct actggaaggc cacgcaccgg agcccgggcc agatccacct 720 ggtgcagcgg cacccgccct ccgaggagtc ccaagccttc cagcggcagc tcacggcgct 780 gattggctat gacgtcactg acgtcagcaa cgtgcacgac gatgagctgg agttcacgcg 840 ccgtggcttg gtgaccccgc gcatggcgga ggtggccagc cgcgacccca agctctacgc 900 catgcacccg tgggtgacgt ccaagcccct cccggagtac ctgtggaaga agattgccaa 960 caactgcatc ttcatcgtca ttcaccgcag caccaccagc cagaccatta aggtctcacc 1020 cgacgacacc cccggcgcca tcctgcagag cttcttcacc aagatggcca agaagaaatc 1080 tctgatggat attcccgaaa gccaaagcga acaggatttt gtgctgcgcg tctgtggccg 1140 ggatgagtac ctggtgggcg aaacgcccat caaaaacttc cagtgggtga ggcactgcct 1200 caagaacgga gaagagattc acgtggtact ggacacgcct ccagacccgg ccctagacga 1260 ggtgaggaag gaagagtggc cgctggtgga tgactgcacg ggagtcaccg gctaccatga 1320 gcagcttacc atccacggca aggaccacga gagtgtgttc accgtgtccc tgtgggactg 1380 cgaccgcaag ttcagggtca agatcagagg cattgatatc cccgtcctgc ctcggaacac 1440 cgacctcaca gtttttgtag aggcaaacat ccagcatggg caacaagtcc tttgccaaag 1500 gagaaccagc cccaaaccct tcacagagga ggtgctgtgg aatgtgtggc ttgagttcag 1560 tatcaaaatc aaagacttgc ccaaaggggc tctactgaac ctccagatct actgcggtaa 1620 agctccagca ctgtccagca aggcctctgc agagtccccc agttctgagt ccaagggcaa 1680 agttcagctt ctctattatg tgaacctgct gctgatagac caccgtttcc tcctgcgccg 1740 tggagaatac gtcctccaca tgtggcagat atctgggaag ggagaagacc aaggaagctt 1800 caatgctgac aaactcacgt ctgcaactaa cccagacaag gagaactcaa tgtccatctc 1860 cattcttctg gacaattact gccacccgat agccctgcct aagcatcagc ccacccctga 1920 cccggaaggg gaccgggttc gagcagaaat gcccaaccag cttcgcaagc aattggaggc 1980 gatcatagcc actgatccac ttaaccctct cacagcagag gacaaagaat tgctctggca 2040 ttttagatac gaaagcctta agcacccaaa agcatatcct aagctattta gttcagtgaa 2100 atggggacag caagaaattg tggccaaaac ataccaattg ttggccagaa gggaagtctg 2160 ggatcaaagt gctttggatg ttgggttaac aatgcagctc ctggactgca acttctcaga 2220 tgaaaatgta agagccattg cagttcagaa actggagagc ttggaggacg atgatgttct 2280 gcattacctt ctacaattgg tccaggctgt gaaatttgaa ccataccatg atagcgccct 2340 tgccagattt ctgctgaagc gtggtttaag aaacaaaaga attggtcact ttttgttttg 2400 gttcttgaga agtgagatag cccagtccag acactatcag cagaggttcg ctgtgattct 2460 ggaagcctat ctgaggggct gtggcacagc catgctgcac gactttaccc aacaagtcca 2520 agtaatcgag atgttacaaa aagtcaccct tgatattaaa tcgctctctg ctgaaaagta 2580 tgacgtcagt tcccaagtta tttcacaact taaacaaaag cttgaaaacc tgcagaattc 2640 tcaactcccc gaaagcttta gagttccata tgatcctgga ctgaaagcag gagcgctggc 2700 aattgaaaaa tgtaaagtaa tggcctccaa gaaaaaacca ctatggcttg agtttaaatg 2760 tgccgatcct acagccctat caaatgaaac aattggaatt atctttaaac atggtgatga 2820 tctgcgccaa gacatgctta ttttacagat tctacgaatc atggagtcta tttgggagac 2880 tgaatctttg gatctatgcc tcctgccata tggttgcatt tcaactggtg acaaaatagg 2940 aatgatcgag attgtgaaag acgccacgac aattgccaaa attcagcaaa gcacagtggg 3000 caacacggga gcatttaaag atgaagtcct gaatcactgg ctcaaagaaa aatcccctac 3060 tgaagaaaag tttcaggcag cagtggagag atttgtttat tcctgtgcag gctactgtgt 3120 ggcaaccttt gttcttggaa taggcgacag acacaatgac aatattatga tcaccgagac 3180 aggaaaccta tttcatattg acttcgggca cattcttggg aattacaaaa gtttcctggg 3240 cattaataaa gagagagtgc catttgtgct aacccctgac ttcctctttg tgatgggaac 3300 ttctggaaag aagacaagcc cacacttcca gaaatttcag gacatctgtg ttaaggctta 3360 tctagccctt cgtcatcaca caaacctact gatcatcctg ttctccatga tgctgatgac 3420 aggaatgccc cagttaacaa gcaaagaaga cattgaatat atccgggatg ccctcacagt 3480 ggggaaaaat gaggaggatg ctaaaaagta ttttcttgat cagatcgaag tttgcagaga 3540 caaaggatgg actgtgcagt ttaattggtt tctacatctt gttcttggca tcaaacaagg 3600 agagaaacat tcagcctaat actttaggct agaatcaaaa acaagttagt gttctatggt 3660 ttaaattagc atagcaatca tcgaacttgg atttcaaatg caatagacat tgtgaaagct 3720 ggcatttcag aagtatagct cttttcctac ctgaactctt ccctggagaa aagatgttgg 3780 cattgctgat tgtttggtta agcaatgtcc agtgctagga ttatttgcag gtttggtttt 3840 ttctcatttg tctgtggcat tggagaatat tctcggttta aacagactaa tgacttcctt 3900 attgtccctg atattttgac tatcttacta ttgagtgctt ctggaaattc tttggaataa 3960 ttgatgacat ctattttcat ctgggtttag tctcaatttt ggttatcttt gtgttcctca 4020 agctctttaa agaaaaagat gtaatcgttg taacctttgt ctcattcctt aaatgatgct 4080 tccaaacatc tccttagtgt ctgcaggtgt tagtggtgtg ctaaaagcaa ggaaagcgag 4140 ttagtctttt cagtgtcttt tgcaattcaa ttcttttgtc atgtataact gagacacaca 4200 aacacagcag gagaaatcta aaccgttgtg ccttgacctt cctctgctgg tcttgttcca 4260 gggttatgaa tatgaaaaaa tagagatgag actttttgtg tcaactctgt ccacaagagt 4320 gagttatcta gtatgattag tatagctttc tccagcatgg cagcaggaag taactacagg 4380 gcctctttta tgcctgacat ttcttccctt cctttttccc tgcctccctt tttcatcaat 4440 tgcaatgctc ccacaactct ttacagactt gtgaaatctt caagaacacc tttactctat 4500 aactcaaaaa ttagttgaaa aataattact tctcaaggat tattagaatc ttaggtactt 4560 atttgtaaag atgtttagtg actttttttt caagtatctt attaaaggag gcattctaga 4620 aaatatgaat tagtttccaa atgccttaat tttaaacttt ggcctgaaca gttttttctt 4680 tttcttaatg gaagaagata tttaatatct taaaaatatt ccaagttagg aagaacacta 4740 cttgccttat ccatttccca tttaaaggac ttttaaactt tgacacatcc ttcagatttc 4800 ctgaaaataa ttgaaatatc ttactttaaa aatattttca tctctgaaat atctcgttat 4860 ttattggagg tattgtttaa ccttagagag accattaaat tatttataaa atattttgta 4920 attacctgta gctaatacat tacatagaaa aaaactatgt taacagtgtc tctgtttaag 4980 tataatcaga tataaatata tacttaattt tttaatttta aaaatagata cctgtttgac 5040 tttgaggtag tccagacctt ttcttttttt tttttttttt aatgtgtgca aaagcccaaa 5100 ggttcctaag cctggctgca aagaagaatc aacagggaca ctttttaaaa acactcttat 5160 cagcctgggc aacacagtga gactccatct cttaaaaaaa aaattagctg ggtatagtgg 5220 tatgtgcctg tagtcccagg tactcaggag gctgaggcag gaggattgcc tgagcccagg 5280 aggtggaaac tgcagagagt catgatcatg tccttacact ccagcctgga taacagagcg 5340 agaccctgtc tcaaaaaaat aaaataaaaa ataaaaaca 5379 <210> 61 <211> 2440 <212> DNA <213> Homo sapiens acyloxyacyl hydrolase (neutrophil) (AOAH) <400> 61 aacagatcag ttccggcaag cctcgaggct cacggggttt atgcacacta acttcactga 60 gccagggagc acggaagttg tgccactgtg caacttgggt tttctttatc ctgcagtctt 120 tacctcagca gaaccgcaca ccacagactc cctccagctc tttgtgtgtg gctctctcag 180 ggtccaacaa gagcaagctg tgggtctgtg agtgtttatg tgtgctttta ttcacttcac 240 acttattgaa aagtgtgtat gtgagagggt ggggtgtgtg tgtcaaagag agtgaggaag 300 agaaggagag agagatcaat tgattctgca gcctcagctc cagcatccct cagttgggag 360 cttccaaagc cgggtgatca cttggggtgc atagctcgga gatgcagtcc ccctggaaaa 420 tccttacggt ggcgcctcta ttcttgctcc tgtctcttca gtcctcggcc tctccagcca 480 acgatgacca gtccaggccc agcctctcga atgggcacac ctgtgtaggg tgtgtgctgg 540 tggtgtctgt aatagaacag cttgctcaag ttcacaactc gacggtccag gcctcgatgg 600 agagactgtg cagctacctg cctgaaaaac tgttcttgaa aaccacctgc tatttagtca 660 ttgacaagtt tggatcagac atcataaaac tgcttagcgc agatatgaat gctgatgtgg 720 tatgtcacac tctggagttt tgtaaacaga acactggcca accattgtgt catctctacc 780 ctcttcccaa ggagacatgg aaatttacac tacagaaggc aagacaaatt gtcaagaagt 840 ccccgattct gaaatattct agaagtggtt ctgacatttg ttcactcccg gttttggcca 900 agatctgcca gaaaattaaa ttagctatgg aacagtctgt gccattcaaa gatgtggatt 960 cagacaaata cagcgttttc ccaacactgc ggggctatca ctggcggggg agagactgta 1020 atgacagcga cgagtcagtg tacccaggta gaaggccgaa caactgggat gtccatcagg 1080 attcaaactg taatggcatt tggggtgtcg atccaaaaga tggagttcca tatgagaaga 1140 aattctgtga aggttcacag cccaggggaa tcattttgct gggagactca gctggggctc 1200 attttcacat ctctcctgaa tggatcacag cgtcgcagat gtctttgaac tctttcatca 1260 atctaccaac agcccttacc aacgagcttg actggcccca actctctggt gctacaggat 1320 ttctggactc cactgttgga attaaagaaa aatctattta ccttcgctta tggaaaagaa 1380 accactgtaa tcacagggac taccagaata tttcaagaaa tggtgcatct tcccgaaacc 1440 tgaagaaatt tatagaaagc ttgtctagaa acaaggtgtt ggactatccc gccatcgtta 1500 tatatgccat gattggaaat gatgtctgca gtgggaagag tgacccagtc ccagccatga 1560 ccactcctga gaaactctac tccaacgtca tgcagactct gaagcatcta aattcccacc 1620 tgcccaatgg cagccatgtt attttgtatg gcttaccaga tggaaccttt ctctgggata 1680 atttgcacaa cagatatcat cctctcggcc agctaaataa agacatgacc tatgcgcagt 1740 tgtactcctt cctgaactgc ctccaggtca gcccctgcca cggctggatg tcttccaaca 1800 agacgttgcg gactctcact tcagagagag cagagcaact ctccaacaca ctgaaaaaaa 1860 ttgcagccag tgagaaattt acaaacttca atcttttcta catggatttt gccttccatg 1920 aaatcataca ggagtggcag aagagaggcg gacagccctg gcagctcatc gagcccgtgg 1980 atggattcca ccccaacgag gtggctttgc tgttgttggc ggatcatttc tggaaaaagg 2040 tgcagctcca gtggccccaa atcctgggaa aggagaatcc gttcaacccc cagattaaac 2100 aggtgtttgg agaccaaggc gggcactgag cctctcagga gcatgcaccc ctggggagca 2160 cagggaggca gaggcttggg taaactcatt ccacaaaccc tatgggggct gccacgtcac 2220 aggcccaaag gactcttctt cagcagcatc tttgcaaaat gtctttctct caatgaagag 2280 catatctgga cgactgtgca atgctgtgtg ctcccgggat cagtaaccct tccgctgttc 2340 ctgaaataac ctttcataaa gtgctttggg tgccattcca aacaagagag tatctgtgcc 2400 ctttacagct aattgttcta aaaggagttt ctaaaaacac 2440 <210> 62 <211> 925 <212> DNA <213> Homo sapiens clone DNA144844 DTFT5783 (UNQ5783) <400> 62 tgaaggcctg tgagtgagga atgcctctca ccagctgtgc ctgagctgca gcactccagc 60 cactgctgtc tccttagctg ctcacatatg gatactttca cagttcagga ttccactgca 120 atgagctggt ggaggaataa tttctggatc atcttagctg tggccatcat tgttgtctct 180 gtgggcctgg gcctcatcct gtactgtgtc tgtaagtggc agcttagacg aggcaagaaa 240 tgggaaattg ccaagcccct gaaacacaag caagtagatg aagaaaagat gtatgagaat 300 gttcttaatg agtcgccagt tcaattaccg cctctgccac cgaggaattg gccttctcta 360 gaagactctt ccccacagga agccccaagt cagccgcccg ctacatactc actggtaaat 420 aaagttaaaa ataagaagac tgtttccatc ccaagctaca ttgagcctga agatgactat 480 gacgatgttg aaatccctgc aaatactgaa aaagcatcat tttgaaacag ccatttcttc 540 tttttggcaa aactgaagag ggttcacaca acttatttta aaacaatcaa gaatggttga 600 acttcagtag gtctctgggc cctgaaagcc agtggtgatt ttatgaagct ctataagata 660 aagcacttcc caaaccttag atgaagacac ccctgcgatc ggatgactgc agccagagga 720 gacacatggg tgctcggctc tgaggactta gaggggtcag ccttgtgctg ttgaggaaac 780 tttccatggg aaggaccacg gggctccatg gctcccacct gtgggaaact actcatttct 840 tggcattctt tcccccttca ttccctttgg tttgcatggt tctgagtgat attaaatctc 900 agcatttggt tgtgcaaaaa aaaaa 925 <210> 63 <211> 5471 <212> DNA <213> Homo sapiens family with sequence similarity 65, member B (FAM65B) <400> 63 ccggggtccc cttcacccaa gtgagccagc tcaggctgtc tgcaaagccg gaggtgcggg 60 cagctccggg cattgcattg gtgcggaggc ttttatatgc cagagaaccc tgagtgtgcc 120 cctgacatga caaggagccg tcgtcgttag gactaccgac cagactcccg gaaatcatgt 180 tggtaggatc ccagtctttt tcgcctggag ggcccaatgg gatcattaga agccagtcct 240 ttgcgggttt cagcggcctc caggaaaggc gatccaggtg taactccttc attgaaaatt 300 cctccgctct caagaagcct caggccaaac tgaagaaaat gcacaattta ggccacaaaa 360 acaacaatcc ccccaaagag cctcagccta aaagggtgga agaagtctac agggccttga 420 aaaatggact tgatgaatat ctggaggttc accagacgga gctggacaag ttgacagctc 480 agttaaaaga tatgaaaaga aactctcgcc tgggtgtact gtatgaccta gacaagcaaa 540 ttaaaacaat tgaaagatac atgagacgcc tggagtttca tataagtaag gtagatgaac 600 tctatgaagc ttattgtatc cagcgacgcc tccaggatgg tgccagcaaa atgaagcaag 660 ccttcgcaac atcccctgcc agcaaagctg cccgggagag tctgacagag atcaatcgga 720 gcttcaagga gtacacagag aatatgtgca ccattgaagt ggagctagag aatctgctgg 780 gagaattctc catcaagatg aaaggtctgg ctggctttgc acgcctctgt cctggagatc 840 aatatgaaat tttcatgaag tatggccggc agcggtggaa actgaaaggc aaaatagaag 900 taaatggcaa gcagagctgg gatggagaag aaacagtttt tctgcccctg atagttgggt 960 tcatctccat caaggtcacg gagctcaaag ggctagcaac tcacatcctg gtaggtagcg 1020 tgacctgtga gaccaaagag ctgtttgcag cccgacctca ggtagtggct gtcgacatca 1080 atgaccttgg taccatcaaa ctgaacctgg aaatcacctg gtatccattt gacgtggagg 1140 acatgaccgc atcctcaggc gctgggaaca aggcagcagc ccttcagagg agaatgtcca 1200 tgtacagcca gggtaccccg gaaacgccca ccttcaaaga ccactccttc tttaggtggc 1260 tgcatccttc cccagacaag cccaggcggc tgtctgtctt gagtgccttg caagacactt 1320 tctttgccaa gctgcaccgc agccgctcct tcagtgacct gccctccctc aggccgagtc 1380 ccaaggccgt gctagagctc tattcaaatc tacctgatga catctttgaa aatggaaagg 1440 cagccgagga gaaaatgcca ctgtcgctca gcttcagtga cctgcccaac ggggactgcg 1500 ccctcacctc ccactcaaca ggctcccctt ccaactcaac aaatccagaa attaccatca 1560 cccctgcgga gtttaacctc agcagcttgg cctcccagaa tgagggtatg gatgacacca 1620 gctcagcatc ttccaggaac tccctgggag aaggccaaga gccaaagtca cacctgaagg 1680 aggaagaccc agaggagccc agaaaacctg cctcggcccc atctgaggct tgccgccgac 1740 agtcctcagg tgctggggct gagcacctgt tccttgagaa tgatgttgca gaagcacttc 1800 tgcaagagtc tgaggaggcc tctgagctca agcctgtgga actggacact tcggaaggaa 1860 acatcacaaa gcagctggtc aagaggctca catctgcaga ggtgccaatg gccacagaca 1920 ggctgctctc tgagggttct gttggtggag aatctgaagg ctgcagatcc tttctagatg 1980 gaagcttaga ggatgctttt aatgggcttt tacttgcatt agaaccacat aaagagcagt 2040 ataaagagtt tcaggatctg aaccaagaag tcatgaattt ggatgatatt ctaaaatgca 2100 agccagcagt aagccgcagc aggtcttcca gtttaagtct cacagttgaa agtgctttag 2160 aaagctttga tttcctgaac acctctgatt ttgacgagga ggaggatggt gatgaggttt 2220 gtaatgttgg cggaggtgct gactcagtat tttcagacac tgagactgag aaacacagtt 2280 acaggtcggt tcacccagaa gccagggggc atctcagtga agcgctcact gaagacacag 2340 gagttgggac cagtgtggca ggaagtcctc tcccactgac cacaggcaac gagagcctgg 2400 acatcaccat cgtcaggcac ctccagtact gcacccaact cgtgcagcaa attgttttct 2460 caagcaaaac cccatttgtg gcaagaagtc tcttagagaa gctttctagg cagatccaag 2520 tgatggagaa actcgcagct gtcagtgatg agaacatagg aaatatcagt tctgttgtgg 2580 aagccatacc agaatttcac aaaaagctgt ctttgctgtc attctggacc aagtgctgca 2640 gccctgttgg tgtctaccac agcccagcgg acagagtgat gaagcagctg gaggccagct 2700 ttgccagaac tgtcaacaaa gaatatccag gacttgcaga cccagtgttt cgaaccctgg 2760 tgtcccaaat tctggaccgg gctgagcctc tgctttcctc cagcctgtcc tcggaagtcg 2820 tcactgtttt ccagtattac agttacttca ccagccacgg cgtcagtgac ctggagagtt 2880 acctgagcca gctggccagg caagtttcca tggttcagac tctgcaatca ctaagagatg 2940 aaaaactgct acaaaccatg agtgaccttg ctcccagcaa cctcctggcc cagcaggaag 3000 tactcaggac tctggctctg ctattaacca gagaggacaa cgaagttagt gaggctgtga 3060 cgctttactt ggcagcagcc tccaaaaatc agcatttcag ggaaaaggcc ttgctctatt 3120 actgtgaagc actaacaaag acaaacctcc agctccagaa agcagcttgc ctggctctga 3180 aaatccttga ggctactgaa agcattaaaa tgctggtgac attgtgtcaa tctgatactg 3240 aagaaatcag aaatgtggcc tcagaaaccc tcttgtctct gggagaagat gggcggctgg 3300 catatgaaca attggacaaa tttcctcgag actgtgttaa agtcggaggt cgtcatggaa 3360 ctgaagttgc cacagccttt taattacagg ttaactgcct aacagctgtc ttaatatctg 3420 gcccttttca tcaggatggt gctgtggttt gggctggaaa ttgtttagag cctgagagac 3480 acgacaactg aaataaaaat gtaggccagg tgcagtggct catgcctgta atcccagtac 3540 tttgggaggc caacgcagga gaattgctta agcccaggag gttcaagacc aacctgggca 3600 acatagcaag gccctgtctc tacaaaaaaa atagtttaat tagtcaggcg tggtggcatg 3660 cacctgtagt cccagctact tgggaggcta aggtgggagg attgcttgag cccagaagat 3720 tcaggctgca gtgagccata attgccccac tgcactccag actgggtgac agagcaaaac 3780 cctgtctcaa aaaacaaaac aacaacaaca actaaaaaaa catgttatag aaagaattca 3840 gagtctcgtt tcacagtacc tatctacttt tcctttggcc aatatagaat agggctatgg 3900 tataattcaa atatattaca tcgtcgattg tgtctaataa tactcagtga aagagtccat 3960 cttatcttaa tatgtatgaa atttaaaaat agccatcttt gtactttttt gcaagtttct 4020 ctataagctt gaaatagtca tgtgatactt cgacaaacat catatgcctt gcagtttttc 4080 tcggtcgtgt tctcagggtt gagtagtccc cttagctacc taactttact ttcaatacaa 4140 agcacaaaaa agaatatctt caaataaaag tttgcctgca gaacctggca aaatgaccca 4200 ttaggagagt ttagatgttt taattttatg tgctcccagc tactctggag tctgaggtgg 4260 gaggatcact tgaggcagag gttgcagtaa gctgagatta cactactgca ctccagccca 4320 tgtgacagag gaatgagagc cagtctcaaa aaaaaaaaca aaaaactccc ataatttatt 4380 ttgtttcttt tccccatcct gaaaattccc aaatcatgtt tccattatgg aaaaatgata 4440 agtaaatgac taagaactac attaagatta tgcctataca cttaaacaaa aaactcaaag 4500 cttatgcttt ttttttttta attaatgaga gctatttttt atgatattct taccataggg 4560 gtgttttgct gctaagacaa atcaaaacca aaagctgtag attcacaaac ctgtgatgct 4620 ctttgaggtg gaggaaccta gaagtcagag aaatcctaat ggagtaggag tggaggaaca 4680 tttaaagtgg tccctccttc tgtaaaaatg accgtgggat tagaaagaag gacatcctga 4740 ggggtggtta ctgcccccag ggaaatcact cactggtagg attccctggc caaatagttc 4800 aaacatcagg tcccattatt gcttcagtat cagagatgca agttcattaa gcaaagtaca 4860 agaccattca gtagctctta ttaaaatatc ttttcttcct ctaaagagtg tacaaggtgg 4920 ggtatgccaa ggtatcaaaa caatatatgt gagtgtaatt taaactgtgg aatatcaact 4980 gtactatgga cgtgtttgta tcatttagat gtcattttaa atatttacat tttagcaaga 5040 cttttaaaaa ggactcattt catttcaaag tgcaaattgt ttgccaggct tctggcaaat 5100 ggttctttca actgtgaact tatcgtgtac atatctgtat atttataaat attatatata 5160 ttcatacatc cttcacttta aaggtacatt gtacagtctg tagttaggag gtatagccta 5220 tagcttatgt taaatggttg aaatggttct ttttatagaa agtcaaacac agatgttaca 5280 ggattttgtg tttggtttgt cattttttta ttttttattt tgactattgc atgagtaatt 5340 aattccagat cttttgtatt cacttctgta ttttatgttt ggttgagggg tgcttttagt 5400 tgtgtggcat ttgtattcat tgatctttca gtcatgtaag ttaaaataaa aattattttt 5460 gaattactag c 5471 <210> 64 <211> 5226 <212> DNA <213> Homo sapiens integrin, alpha L (ITGAL) <400> 64 acacctccct ccccgcctgc cagtgtcacc agcctgttgc ctctgtgaga aagtaccact 60 gtaagaggcc aaagggcatg atcattttcc tctttcaccc tgtctaggtt gccagcaaat 120 cccacgggcc tcctgacgct gcccctgggg ccacaggtcc ctcgagtgct ggaaggatga 180 aggattcctg catcactgtg atggccatgg cgctgctgtc tgggttcttt ttcttcgcgc 240 cggcctcgag ctacaacctg gacgtgcggg gcgcgcggag cttctcccca ccgcgcgccg 300 ggaggcactt tggataccgc gtcctgcagg tcggaaacgg ggtcatcgtg ggagctccag 360 gggaggggaa cagcacagga agcctctatc agtgccagtc gggcacagga cactgcctgc 420 cagtcaccct gagaggttcc aactatacct ccaagtactt gggaatgacc ttggcaacag 480 accccacaga tggaagcatt ttggcctgtg accctgggct gtctcgaacg tgtgaccaga 540 acacctatct gagtggcctg tgttacctct tccgccagaa tctgcagggt cccatgctgc 600 aggggcgccc tggttttcag gaatgtatca agggcaacgt agacctggta tttctgtttg 660 atggttcgat gagcttgcag ccagatgaat ttcagaaaat tctggacttc atgaaggatg 720 tgatgaagaa actcagcaac acttcgtacc agtttgctgc tgttcagttt tccacaagct 780 acaaaacaga atttgatttc tcagattatg ttaaacggaa ggaccctgat gctctgctga 840 agcatgtaaa gcacatgttg ctgttgacca atacctttgg tgccatcaat tatgtcgcga 900 cagaggtgtt ccgggaggag ctgggggccc ggccagatgc caccaaagtg cttatcatca 960 tcacggatgg ggaggccact gacagtggca acatcgatgc ggccaaagac atcatccgct 1020 acatcatcgg gattggaaag cattttcaga ccaaggagag tcaggagacc ctccacaaat 1080 ttgcatcaaa acccgcgagc gagtttgtga aaattctgga cacatttgag aagctgaaag 1140 atctattcac tgagctgcag aagaagatct atgtcattga gggcacaagc aaacaggacc 1200 tgacttcctt caacatggag ctgtcctcca gcggcatcag tgctgacctc agcaggggcc 1260 atgcagtcgt gggggcagta ggagccaagg actgggctgg gggctttctt gacctgaagg 1320 cagacctgca ggatgacaca tttattggga atgaaccatt gacaccagaa gtgagagcag 1380 gctatttggg ttacaccgtg acctggctgc cctcccggca aaagacttcg ttgctggcct 1440 cgggagcccc tcgataccag cacatgggcc gagtgctgct gttccaagag ccacagggcg 1500 gaggacactg gagccaggtc cagacaatcc atgggaccca gattggctct tatttcggtg 1560 gggagctgtg tggcgtcgac gtggaccaag atggggagac agagctgctg ctgattggtg 1620 ccccactgtt ctatggggag cagagaggag gccgggtgtt tatctaccag agaagacagt 1680 tggggtttga agaagtctca gagctgcagg gggaccccgg ctacccactc gggcggtttg 1740 gagaagccat cactgctctg acagacatca acggcgatgg gctggtagac gtggctgtgg 1800 gggcccctct ggaggagcag ggggctgtgt acatcttcaa tgggaggcac ggggggctta 1860 gtccccagcc aagtcagcgg atagaaggga cccaagtgct ctcaggaatt cagtggtttg 1920 gacgctccat ccatggggtg aaggaccttg aaggggatgg cttggcagat gtggctgtgg 1980 gggctgagag ccagatgatc gtgctgagct cccggcccgt ggtggatatg gtcaccctga 2040 tgtccttctc tccagctgag atcccagtgc atgaagtgga gtgctcctat tcaaccagta 2100 acaagatgaa agaaggagtt aatatcacaa tctgtttcca gatcaagtct ctcatccccc 2160 agttccaagg ccgcctggtt gccaatctca cttacactct gcagctggat ggccaccgga 2220 ccagaagacg ggggttgttc ccaggaggga gacatgaact cagaaggaat atagctgtca 2280 ccaccagcat gtcatgcact gacttctcat ttcatttccc ggtatgtgtt caagacctca 2340 tctcccccat caatgtttcc ctgaatttct ctctttggga ggaggaaggg acaccgaggg 2400 accaaagggc gcagggcaag gacataccgc ccatcctgag accctccctg cactcggaaa 2460 cctgggagat cccttttgag aagaactgtg gggaggacaa gaagtgtgag gcaaacttga 2520 gagtgtcctt ctctcctgca agatccagag ccctgcgtct aactgctttt gccagcctct 2580 ctgtggagct gagcctgagt aacttggaag aagatgctta ctgggtccag ctggacctgc 2640 acttcccccc gggactctcc ttccgcaagg tggagatgct gaagccccat agccagatac 2700 ctgtgagctg cgaggagctt cctgaagagt ccaggcttct gtccagggca ttatcttgca 2760 atgtgagctc tcccatcttc aaagcaggcc actcggttgc tctgcagatg atgtttaata 2820 cactggtaaa cagctcctgg ggggactcgg ttgaattgca cgccaatgtg acctgtaaca 2880 atgaggactc agacctcctg gaggacaact cagccactac catcatcccc atcctgtacc 2940 ccatcaacat cctcatccag gaccaagaag actccacact ctatgtcagt ttcaccccca 3000 aaggccccaa gatccaccaa gtcaagcaca tgtaccaggt gaggatccag ccttccatcc 3060 acgaccacaa catacccacc ctggaggctg tggttggggt gccacagcct cccagcgagg 3120 ggcccatcac acaccagtgg agcgtgcaga tggagcctcc cgtgccctgc cactatgagg 3180 atctggagag gctcccggat gcagctgagc cttgtctccc cggagccctg ttccgctgcc 3240 ctgttgtctt caggcaggag atcctcgtcc aagtgatcgg gactctggag ctggtgggag 3300 agatcgaggc ctcttccatg ttcagcctct gcagctccct ctccatctcc ttcaacagca 3360 gcaagcattt ccacctctat ggcagcaacg cctccctggc ccaggttgtc atgaaggttg 3420 acgtggtgta tgagaagcag atgctctacc tctacgtgct gagcggcatc ggggggctgc 3480 tgctgctgct gctcattttc atagtgctgt acaaggttgg tttcttcaaa cggaacctga 3540 aggagaagat ggaggctggc agaggtgtcc cgaatggaat ccctgcagaa gactctgagc 3600 agctggcatc tgggcaagag gctggggatc ccggctgcct gaagcccctc catgagaagg 3660 actctgagag tggtggtggc aaggactgag tccaggcctg tgaggtgcag agtgcccaga 3720 actggactca ggatgcccag ggccactctg cctctgcctg cattctgccg tgtgccctcg 3780 ggcgagtcac tgcctctccc tggccctcag tttccctatc tcgaacatgg aactcattcc 3840 tgcctgtctc ctttgcaggc tcatagggaa gacctgctga gggaccagcc aagagggctg 3900 caaaagtgag ggcttgtcat taccagacgg ttcaccagcc tctcttggtt tccttccttg 3960 gaagagaatg tctgatctaa atgtggagaa actgtagtct caggacctag ggatgttctg 4020 gccctcaccc ctgccctggg atgtccacag atgcctccac cccccagaac ctgtccttgc 4080 acactcccct gcactggagt ccagtctctt ctgctggcag aaagcaaatg tgacctgtgt 4140 cactacgtga ctgtggcaca cgccttgttc ttggccaaag accaaattcc ttggcatgcc 4200 ttccagcacc ctgcaaaatg agaccctcgt ggccttcccc agcctcttct agagccgtga 4260 tgcctccctg ttgaagctct ggtgacacca gcctttctcc caggccaggc tccttcctgt 4320 cttcctgcat tcacccagac agctccctct gcctgaacct tccatctcgc cacccctcct 4380 tccttgacca gcagatccca gctcacgtca cacttggttg ggtcctcaca tctttcacac 4440 ttccaccagc ctgcactact ccctcaaagc acacgtcatg tttcttcatc cggcagcctg 4500 gatgtttttt ccctgtttaa tgattgacgt acttagcagc tatctctcag tgaactgtga 4560 gggtaaaggc tatacttgtc ttgttcacct tgggatgatg cctcatgata tgtcagggcg 4620 tgggacatct agtaggtgct tgacataatt tcactgaatt aatgacagag ccagtgggaa 4680 gatacagaaa aagaggggct gggctgggcg cggtggttca cgcctgtaat cccagcactt 4740 tgggaggcca aggagggtgg atcacctgag gtcaggagtt agaggccagc ctggcgaaac 4800 cccatctcta ctaaaaatac aaaatccagg cgtggtggca cacacctgta gtcccagcta 4860 ctcaggaggt tgaggtagga gaattgcttg aacctgggag gtggaggttg cagtgagcca 4920 agattgcgcc attgcactcc agcctgggca acacagcgag actccgtctc aaggaaaaaa 4980 taaaaataaa aagcgggcac gggcccgtga catccccacc cttggaggct gtcttctcag 5040 gctctgccct gccctagctc cacaccctct cccaggaccc atcacgcctg tgcagtggcc 5100 cccacagaaa gactgagctc aaggtgggaa ccacgtctgc taacttggag ccccagtgcc 5160 aagcacagtg cctgcatgta tttatccaat aaatgtgaaa ttctgtccaa aaaaaaaaaa 5220 aaaaaa 5226 <210> 65 <211> 2009 <212> DNA <213> Homo sapiens ecotropic viral integration site 2B (EVI2B) <400> 65 agaaactatt tcagtttgct agaggaacat tttaaatctg aattgaacca cccattttcc 60 tttcttagcc aaatcaccaa aatgtccagt tagaacaaga atttagcatt ctgcaaaaga 120 agttaacagc tgagataacg aggaaatatt ctgaaatgga tcccaaatat ttcatcttaa 180 ttttgttttg tggacacctg aacaatacat ttttttcaaa gacagagaca attacaacag 240 agaagcagtc acagcctacc ttattcacat catcaatgtc acaggtattg gctaattctc 300 aaaacacaac agggaatcct ttgggtcaac caacacaatt cagcgacact ttttctggac 360 aatcaatatc acctgccaaa gtcactgctg gacaaccaac accagctgtc tatacctctt 420 ctgaaaaacc agaagcacat acttctgctg gacaaccact tgcctacaac accaaacaac 480 caacaccaat agccaacacc tcctcccagc aagccgtgtt cacctctgcc agacaactac 540 catctgcccg tacttctacc acacaaccac caaagtcatt tgtctatact tttactcaac 600 aatcatcatc tgtccagatc ccttctagaa aacaaataac tgttcataat ccatccacac 660 aaccaacatc aactgtcaaa aattcaccta ggagtacacc aggatttatc ttagatacta 720 ccagtaacaa acaaacccca caaaaaaaca attataattc aatagctgcc atactaattg 780 gtgtacttct gacttctatg ttggtagcta taatcatcat tgtactttgg aaatgcttaa 840 ggaaaccagt tttaaatgat caaaattggg caggtagatc tccatttgct gatggagaaa 900 cccctgacat ttgtatggat aacatcagag aaaatgaaat atccacaaaa cgtacatcaa 960 tcatttcact tacaccctgg aaaccaagca aaagcacact tttagcagat gacttagaaa 1020 ttaagttgtt tgaatcaagt gaaaacattg aagactccaa caaccccaaa acagagaaaa 1080 taaaagatca agtaaatggt acatcagaag atagtgctga tggttcaaca gttggaactg 1140 ctgtttcttc ttcagatgat gcagatctgc ctccaccacc tccccttctg gatttggaag 1200 gacaggaaag taaccaatct gacaaaccca caatgacaat tgtatctcct cttccaaatg 1260 attctactag tctccctcca tctctggact gtctcaatca agactgtgga gatcataaat 1320 ctgagataat acaatcattt ccaccgcttg actcacttaa cttgcccctg ccaccagtag 1380 attttatgaa aaaccaagaa gattccaacc ttgagatcca gtgtcaggag ttctctattc 1440 ctcccaactc tgatcaagat cttaatgaat ccctgccacc tccacctgca gaactgttat 1500 aaatattaca acttgctttt tagctgatct tccatcctca aatgactctt ttttctttat 1560 atgttaacat atataaaatg gcaactgata gtcaattttg atttttattc aggaactatc 1620 tgaaatctgc tcagagccta tgtgcataga tgaaactttt ttttaaaaaa agttatttaa 1680 cagtaatcta tttactaatt atagtaccta tctttaaagt atagtacatt ttacatatgt 1740 aaatggtatg tttcaataat ttaagaactc tgaaacaatc tacatatact tattacccag 1800 tacagttttt tttcccctga aaagctgtgt ataaaattat ggtgaataaa cttttatgtt 1860 tccatttcaa agaccagggt ggagaggaat aagagactaa gtatatgctt caagttttaa 1920 attaatacct caagtattaa ataaatattc caagtttgtg ggaatgggag attaaaatgc 1980 atgtttgaga atagaaaaaa aaaaaaaaa 2009 <210> 66 <211> 2050 <212> DNA <213> Homo sapiens hematopoietic cell-specific Lyn substrate 1 (HCLS1) <400> 66 gaaaacctga atacggaact gaagcagcag ctcagtttct cactccgaag tggcagcagc 60 cagagaggga gtcggtgtgg acgcgaggag ccgggcgctt agaacagagg cttgcacagg 120 tggagatgtg gaagtctgta gtgggccatg atgtgtctgt ttccgtggag acccagggtg 180 atgattggga cacagatcct gactttgtga atgacatctc tgaaaaggag caacgatggg 240 gagccaagac catcgagggg tctggacgca cagaacacat caacatccac cagctgagga 300 acaaagtatc agaggagcat gatgttctca ggaagaaaga gatggagtca gggcccaaag 360 catcccatgg ctatggaggt cggtttggag tagaaagaga ccgaatggac aagagtgcag 420 tgggccatga gtatgttgcc gaggtggaga agcactcttc tcagacggat gctgccaaag 480 gctttggggg caagtacgga gttgagaggg acagggcaga caagtcagca gtcggctttg 540 attataaagg agaagtggag aagcacacat ctcagaaaga ttactctcgt ggctttggtg 600 gccggtacgg ggtggagaag gataaatggg acaaagcagc tctgggatat gactacaagg 660 gagagacgga gaaacacgag tcccagagag attatgccaa gggctttggt ggccagtatg 720 gaatccagaa ggaccgagtg gataagagcg ctgtcggctt caatgaaatg gaggccccga 780 ccacagctta taagaagacg acgcccatag aagccgcttc tagtggtacc cgtgggctga 840 aggcgaaatt tgagtccatg gctgaggaga agaggaagcg agaggaagag gagaaggcac 900 agcaggtggc caggaggcaa caggagcgaa aggctgtgac aaagaggagc cctgaggctc 960 cacagccagt gatagctatg gaagagccag cagtaccggc cccactgccc aagaaaatct 1020 cctcagaggc ctggcctcca gttgggactc ctccatcatc agagtctgag cctgtgagaa 1080 ccagcaggga acacccagtg cccttgctgc ccattaggca gactctcccg gaggacaatg 1140 aggagccccc agctctgccc cctaggactc tggaaggcct ccaggtggag gaagagccag 1200 tgtacgaagc agagcctgag cctgagcccg agcctgagcc cgagcctgag aatgactatg 1260 aggacgttga ggagatggac aggcatgagc aggaggatga accagagggg gactatgagg 1320 aggtgctcga gcctgaagat tcttcttttt cttctgctct ggctggatca tcaggctgcc 1380 cggctggggc tggggctggg gctgtggctc tggggatctc agctgtggct ctatatgatt 1440 accaaggaga gggaagtgat gagctttcct ttgatccgga cgacgtaatc actgacattg 1500 agatggtgga cgagggctgg tggcggggac gttgccatgg ccactttgga ctcttccctg 1560 caaattatgt caagcttctg gagtgactag agctcactgt ctactgcaac tgtgatttcc 1620 catgtccaaa gtggctctgc ctccaccccc tccctattcc tgctgcaaat gtctaaccag 1680 atgaggttct ggacagactt ccctctcctg cttcattaag ggcttggggc agagacagca 1740 tggggaagga ggtccccttc cccaagagtc ctctctatcc tggatgagct catgaacatt 1800 tctcttgtgt tcctgactcc ttcccaatga acacctctct gccaccccaa gctctgctct 1860 cctcctctgt gagctctggg cttcccagtt tgtttacccg ggaaagtacg tctagattgt 1920 gtggtttgcc tcattgtgct atttgcccac tttccttccc tgaagaaata tctgaacctt 1980 ctttctgttc agtcctaaaa ttcgaaataa agtgagacta tggttcacct gtaaaaaaaa 2040 aaaaaaaaaa 2050 <210> 67 <211> 5330 <212> DNA <213> Homo sapiens protein tyrosine phosphatase, receptor type, C (PTPRC) <400> 67 agtatttttg gagaagttag taaaaccgaa tctgacatca tcacctagca gttcatgcag 60 ctagcaagtg gtttgttctt agggtaacag aggaggaaat tgttcctcgt ctgataagac 120 aacagtggag aaaggacgca tgctgtttct tagggacacg gctgacttcc agatatgacc 180 atgtatttgt ggcttaaact cttggcattt ggctttgcct ttctggacac agaagtattt 240 gtgacagggc aaagcccaac accttccccc actggattga ctacagcaaa gatgcccagt 300 gttccacttt caagtgaccc cttacctact cacaccactg cattctcacc cgcaagcacc 360 tttgaaagag aaaatgactt ctcagagacc acaacttctc ttagtccaga caatacttcc 420 acccaagtat ccccggactc tttggataat gctagtgctt ttaataccac aggtgtttca 480 tcagtacaga cgcctcacct tcccacgcac gcagactcgc agacgccctc tgctggaact 540 gacacgcaga cattcagcgg ctccgccgcc aatgcaaaac tcaaccctac cccaggcagc 600 aatgctatct cagatgtccc aggagagagg agtacagcca gcacctttcc tacagaccca 660 gtttccccat tgacaaccac cctcagcctt gcacaccaca gctctgctgc cttacctgca 720 cgcacctcca acaccaccat cacagcgaac acctcagatg cctaccttaa tgcctctgaa 780 acaaccactc tgagcccttc tggaagcgct gtcatttcaa ccacaacaat agctactact 840 ccatctaagc caacatgtga tgaaaaatat gcaaacatca ctgtggatta cttatataac 900 aaggaaacta aattatttac agcaaagcta aatgttaatg agaatgtgga atgtggaaac 960 aatacttgca caaacaatga ggtgcataac cttacagaat gtaaaaatgc gtctgtttcc 1020 atatctcata attcatgtac tgctcctgat aagacattaa tattagatgt gccaccaggg 1080 gttgaaaagt ttcagttaca tgattgtaca caagttgaaa aagcagatac tactatttgt 1140 ttaaaatgga aaaatattga aacctttact tgtgatacac agaatattac ctacagattt 1200 cagtgtggta atatgatatt tgataataaa gaaattaaat tagaaaacct tgaacccgaa 1260 catgagtata agtgtgactc agaaatactc tataataacc acaagtttac taacgcaagt 1320 aaaattatta aaacagattt tgggagtcca ggagagcctc agattatttt ttgtagaagt 1380 gaagctgcac atcaaggagt aattacctgg aatccccctc aaagatcatt tcataatttt 1440 accctctgtt atataaaaga gacagaaaaa gattgcctca atctggataa aaacctgatc 1500 aaatatgatt tgcaaaattt aaaaccttat acgaaatatg ttttatcatt acatgcctac 1560 atcattgcaa aagtgcaacg taatggaagt gctgcaatgt gtcatttcac aactaaaagt 1620 gctcctccaa gccaggtctg gaacatgact gtctccatga catcagataa tagtatgcat 1680 gtcaagtgta ggcctcccag ggaccgtaat ggcccccatg aacgttacca tttggaagtt 1740 gaagctggaa atactctggt tagaaatgag tcgcataaga attgcgattt ccgtgtaaaa 1800 gatcttcaat attcaacaga ctacactttt aaggcctatt ttcacaatgg agactatcct 1860 ggagaaccct ttattttaca tcattcaaca tcttataatt ctaaggcact gatagcattt 1920 ctggcatttc tgattattgt gacatcaata gccctgcttg ttgttctcta caaaatctat 1980 gatctacata agaaaagatc ctgcaattta gatgaacagc aggagcttgt tgaaagggat 2040 gatgaaaaac aactgatgaa tgtggagcca atccatgcag atattttgtt ggaaacttat 2100 aagaggaaga ttgctgatga aggaagactt tttctggctg aatttcagag catcccgcgg 2160 gtgttcagca agtttcctat aaaggaagct cgaaagccct ttaaccagaa taaaaaccgt 2220 tatgttgaca ttcttcctta tgattataac cgtgttgaac tctctgagat aaacggagat 2280 gcagggtcaa actacataaa tgccagctat attgatggtt tcaaagaacc caggaaatac 2340 attgctgcac aaggtcccag ggatgaaact gttgatgatt tctggaggat gatttgggaa 2400 cagaaagcca cagttattgt catggtcact cgatgtgaag aaggaaacag gaacaagtgt 2460 gcagaatact ggccgtcaat ggaagagggc actcgggctt ttggagatgt tgttgtaaag 2520 atcaaccagc acaaaagatg tccagattac atcattcaga aattgaacat tgtaaataaa 2580 aaagaaaaag caactggaag agaggtgact cacattcagt tcaccagctg gccagaccac 2640 ggggtgcctg aggatcctca cttgctcctc aaactgagaa ggagagtgaa tgccttcagc 2700 aatttcttca gtggtcccat tgtggtgcac tgcagtgctg gtgttgggcg cacaggaacc 2760 tatatcggaa ttgatgccat gctagaaggc ctggaagccg agaacaaagt ggatgtttat 2820 ggttatgttg tcaagctaag gcgacagaga tgcctgatgg ttcaagtaga ggcccagtac 2880 atcttgatcc atcaggcttt ggtggaatac aatcagtttg gagaaacaga agtgaatttg 2940 tctgaattac atccatatct acataacatg aagaaaaggg atccacccag tgagccgtct 3000 ccactagagg ctgaattcca gagacttcct tcatatagga gctggaggac acagcacatt 3060 ggaaatcaag aagaaaataa aagtaaaaac aggaattcta atgtcatccc atatgactat 3120 aacagagtgc cacttaaaca tgagctggaa atgagtaaag agagtgagca tgattcagat 3180 gaatcctctg atgatgacag tgattcagag gaaccaagca aatacatcaa tgcatctttt 3240 ataatgagct actggaaacc tgaagtgatg attgctgctc agggaccact gaaggagacc 3300 attggtgact tttggcagat gatcttccaa agaaaagtca aagttattgt tatgctgaca 3360 gaactgaaac atggagacca ggaaatctgt gctcagtact ggggagaagg aaagcaaaca 3420 tatggagata ttgaagttga cctgaaagac acagacaaat cttcaactta tacccttcgt 3480 gtctttgaac tgagacattc caagaggaaa gactctcgaa ctgtgtacca gtaccaatat 3540 acaaactgga gtgtggagca gcttcctgca gaacccaagg aattaatctc tatgattcag 3600 gtcgtcaaac aaaaacttcc ccagaagaat tcctctgaag ggaacaagca tcacaagagt 3660 acacctctac tcattcactg cagggatgga tctcagcaaa cgggaatatt ttgtgctttg 3720 ttaaatctct tagaaagtgc ggaaacagaa gaggtagtgg atatttttca agtggtaaaa 3780 gctctacgca aagctaggcc aggcatggtt tccacattcg agcaatatca attcctatat 3840 gacgtcattg ccagcaccta ccctgctcag aatggacaag taaagaaaaa caaccatcaa 3900 gaagataaaa ttgaatttga taatgaagtg gacaaagtaa agcaggatgc taattgtgtt 3960 aatccacttg gtgccccaga aaagctccct gaagcaaagg aacaggctga aggttctgaa 4020 cccacgagtg gcactgaggg gccagaacat tctgtcaatg gtcctgcaag tccagcttta 4080 aatcaaggtt cataggaaaa gacataaatg aggaaactcc aaacctcctg ttagctgtta 4140 tttctatttt tgtagaagta ggaagtgaaa ataggtatac agtggattaa ttaaatgcag 4200 cgaaccaata tttgtagaag ggttatattt tactactgtg gaaaaatatt taagatagtt 4260 ttgccagaac agtttgtaca gacgtatgct tattttaaaa ttttatctct tattcagtaa 4320 aaaacaactt ctttgtaatc gttatgtgtg tatatgtatg tgtgtatggg tgtgtgtttg 4380 tgtgagagac agagaaagag agagaattct ttcaagtgaa tctaaaagct tttgcttttc 4440 ctttgttttt atgaagaaaa aatacatttt atattagaag tgttaactta gcttgaagga 4500 tctgttttta aaaatcataa actgtgtgca gactcaataa aatcatgtac atttctgaaa 4560 tgacctcaag atgtcctcct tgttctactc atatatatct atcttatata gtttactatt 4620 ttacttctag agatagtaca taaaggtggt atgtgtgtgt atgctactac aaaaaagttg 4680 ttaactaaat taacattggg aaatcttata ttccatatat tagcatttag tccaatgtct 4740 ttttaagctt atttaattaa aaaatttcca gtgagcttat catgctgtct ttacatgggg 4800 ttttcaattt tgcatgctcg attattccct gtacaatatt taaaatttat tgcttgatac 4860 ttttgacaac aaattaggtt ttgtacaatt gaacttaaat aaatgtcatt aaaataaata 4920 aatgcaatat gtattaatat tcattgtata aaaatagaag aatacaaaca tatttgttaa 4980 atatttacat atgaaattta atatagctat ttttatggaa tttttcattg atatgaaaaa 5040 tatgatattg catatgcata gttcccatgt taaatcccat tcataacttt cattaaagca 5100 tttactttga atttctccaa tgcttagaat gtttttacca ggaatggatg tcgctaatca 5160 taataaaatt caaccattat ttttttcttg tttataatac attgtgttat atgttcaaat 5220 atgaaatgtg tatgcaccta ttgaaatatg tttaatgcat ttattaacat ttgcaggaca 5280 cttttacagg ccccaattat ccaatagtct aataattgtt taagatctag 5330 <210> 68 <211> 1534 <212> DNA <213> Homo sapiens CD3e molecule, epsilon (CD3-TCR complex) (CD3E) <400> 68 tattgtcaga gtcctcttgt ttggccttct aggaaggctg tgggacccag ctttcttcaa 60 ccagtccagg tggaggcctc tgccttgaac gtttccaagt gaggtaaaac ccgcaggccc 120 agaggcctct ctacttcctg tgtggggttc agaaaccctc ctcccctccc agcctcaggt 180 gcctgcttca gaaaatgaag tagtaagtct gctggcctcc gccatcttag taaagtaaca 240 gtcccatgaa acaaagatgc agtcgggcac tcactggaga gttctgggcc tctgcctctt 300 atcagttggc gtttgggggc aagatggtaa tgaagaaatg ggtggtatta cacagacacc 360 atataaagtc tccatctctg gaaccacagt aatattgaca tgccctcagt atcctggatc 420 tgaaatacta tggcaacaca atgataaaaa cataggcggt gatgaggatg ataaaaacat 480 aggcagtgat gaggatcacc tgtcactgaa ggaattttca gaattggagc aaagtggtta 540 ttatgtctgc taccccagag gaagcaaacc agaagatgcg aacttttatc tctacctgag 600 ggcaagagtg tgtgagaact gcatggagat ggatgtgatg tcggtggcca caattgtcat 660 agtggacatc tgcatcactg ggggcttgct gctgctggtt tactactgga gcaagaatag 720 aaaggccaag gccaagcctg tgacacgagg agcgggtgct ggcggcaggc aaaggggaca 780 aaacaaggag aggccaccac ctgttcccaa cccagactat gagcccatcc ggaaaggcca 840 gcgggacctg tattctggcc tgaatcagag acgcatctga ccctctggag aacactgcct 900 cccgctggcc caggtctcct ctccagtccc cctgcgactc cctgtttcct gggctagtct 960 tggaccccac gagagagaat cgttcctcag cctcatggtg aactcgcgcc ctccagcctg 1020 atcccccgct ccctcctccc tgccttctct gctggtaccc agtcctaaaa tattgctgct 1080 tcctcttcct ttgaagcatc atcagtagtc acaccctcac agctggcctg ccctcttgcc 1140 aggatattta tttgtgctat tcactccctt ccctttggat gtaacttctc cgttcagttc 1200 cctccttttc ttgcatgtaa gttgtccccc atcccaaagt attccatcta cttttctatc 1260 gccgtcccct tttgcagccc tctctgggga tggactgggt aaatgttgac agaggccctg 1320 ccccgttcac agatcctggc cctgagccag ccctgtgctc ctccctcccc caacactccc 1380 taccaacccc ctaatcccct actccctcca ccccccctcc actgtaggcc actggatggt 1440 catttgcatc tccgtaaatg tgctctgctc ctcagctgag agagaaaaaa ataaactgta 1500 tttggctgca agaaaaaaaa aaaaaaaaaa aaaa 1534 <210> 69 <211> 4992 <212> DNA <213> Homo sapiens toll-like receptor 7 (TLR7) <400> 69 gaagactcca gatataggat cactccatgc catcaagaaa gttgatgcta ttgggcccat 60 ctcaagctga tcttggcacc tctcatgctc tgctctcttc aaccagacct ctacattcca 120 ttttggaaga agactaaaaa tggtgtttcc aatgtggaca ctgaagagac aaattcttat 180 cctttttaac ataatcctaa tttccaaact ccttggggct agatggtttc ctaaaactct 240 gccctgtgat gtcactctgg atgttccaaa gaaccatgtg atcgtggact gcacagacaa 300 gcatttgaca gaaattcctg gaggtattcc cacgaacacc acgaacctca ccctcaccat 360 taaccacata ccagacatct ccccagcgtc ctttcacaga ctggaccatc tggtagagat 420 cgatttcaga tgcaactgtg tacctattcc actggggtca aaaaacaaca tgtgcatcaa 480 gaggctgcag attaaaccca gaagctttag tggactcact tatttaaaat ccctttacct 540 ggatggaaac cagctactag agataccgca gggcctcccg cctagcttac agcttctcag 600 ccttgaggcc aacaacatct tttccatcag aaaagagaat ctaacagaac tggccaacat 660 agaaatactc tacctgggcc aaaactgtta ttatcgaaat ccttgttatg tttcatattc 720 aatagagaaa gatgccttcc taaacttgac aaagttaaaa gtgctctccc tgaaagataa 780 caatgtcaca gccgtcccta ctgttttgcc atctacttta acagaactat atctctacaa 840 caacatgatt gcaaaaatcc aagaagatga ttttaataac ctcaaccaat tacaaattct 900 tgacctaagt ggaaattgcc ctcgttgtta taatgcccca tttccttgtg cgccgtgtaa 960 aaataattct cccctacaga tccctgtaaa tgcttttgat gcgctgacag aattaaaagt 1020 tttacgtcta cacagtaact ctcttcagca tgtgccccca agatggttta agaacatcaa 1080 caaactccag gaactggatc tgtcccaaaa cttcttggcc aaagaaattg gggatgctaa 1140 atttctgcat tttctcccca gcctcatcca attggatctg tctttcaatt ttgaacttca 1200 ggtctatcgt gcatctatga atctatcaca agcattttct tcactgaaaa gcctgaaaat 1260 tctgcggatc agaggatatg tctttaaaga gttgaaaagc tttaacctct cgccattaca 1320 taatcttcaa aatcttgaag ttcttgatct tggcactaac tttataaaaa ttgctaacct 1380 cagcatgttt aaacaattta aaagactgaa agtcatagat ctttcagtga ataaaatatc 1440 accttcagga gattcaagtg aagttggctt ctgctcaaat gccagaactt ctgtagaaag 1500 ttatgaaccc caggtcctgg aacaattaca ttatttcaga tatgataagt atgcaaggag 1560 ttgcagattc aaaaacaaag aggcttcttt catgtctgtt aatgaaagct gctacaagta 1620 tgggcagacc ttggatctaa gtaaaaatag tatatttttt gtcaagtcct ctgattttca 1680 gcatctttct ttcctcaaat gcctgaatct gtcaggaaat ctcattagcc aaactcttaa 1740 tggcagtgaa ttccaacctt tagcagagct gagatatttg gacttctcca acaaccggct 1800 tgatttactc cattcaacag catttgaaga gcttcacaaa ctggaagttc tggatataag 1860 cagtaatagc cattattttc aatcagaagg aattactcat atgctaaact ttaccaagaa 1920 cctaaaggtt ctgcagaaac tgatgatgaa cgacaatgac atctcttcct ccaccagcag 1980 gaccatggag agtgagtctc ttagaactct ggaattcaga ggaaatcact tagatgtttt 2040 atggagagaa ggtgataaca gatacttaca attattcaag aatctgctaa aattagagga 2100 attagacatc tctaaaaatt ccctaagttt cttgccttct ggagtttttg atggtatgcc 2160 tccaaatcta aagaatctct ctttggccaa aaatgggctc aaatctttca gttggaagaa 2220 actccagtgt ctaaagaacc tggaaacttt ggacctcagc cacaaccaac tgaccactgt 2280 ccctgagaga ttatccaact gttccagaag cctcaagaat ctgattctta agaataatca 2340 aatcaggagt ctgacgaagt attttctaca agatgccttc cagttgcgat atctggatct 2400 cagctcaaat aaaatccaga tgatccaaaa gaccagcttc ccagaaaatg tcctcaacaa 2460 tctgaagatg ttgcttttgc atcataatcg gtttctgtgc acctgtgatg ctgtgtggtt 2520 tgtctggtgg gttaaccata cggaggtgac tattccttac ctggccacag atgtgacttg 2580 tgtggggcca ggagcacaca agggccaaag tgtgatctcc ctggatctgt acacctgtga 2640 gttagatctg actaacctga ttctgttctc actttccata tctgtatctc tctttctcat 2700 ggtgatgatg acagcaagtc acctctattt ctgggatgtg tggtatattt accatttctg 2760 taaggccaag ataaaggggt atcagcgtct aatatcacca gactgttgct atgatgcttt 2820 tattgtgtat gacactaaag acccagctgt gaccgagtgg gttttggctg agctggtggc 2880 caaactggaa gacccaagag agaaacattt taatttatgt ctcgaggaaa gggactggtt 2940 accagggcag ccagttctgg aaaacctttc ccagagcata cagcttagca aaaagacagt 3000 gtttgtgatg acagacaagt atgcaaagac tgaaaatttt aagatagcat tttacttgtc 3060 ccatcagagg ctcatggatg aaaaagttga tgtgattatc ttgatatttc ttgagaagcc 3120 ctttcagaag tccaagttcc tccagctccg gaaaaggctc tgtgggagtt ctgtccttga 3180 gtggccaaca aacccgcaag ctcacccata cttctggcag tgtctaaaga acgccctggc 3240 cacagacaat catgtggcct atagtcaggt gttcaaggaa acggtctagc ccttctttgc 3300 aaaacacaac tgcctagttt accaaggaga ggcctggctg tttaaattgt tttcatatat 3360 atcacaccaa aagcgtgttt tgaaattctt caagaaatga gattgcccat atttcagggg 3420 agccaccaac gtctgtcaca ggagttggaa agatggggtt tatataatgc atcaagtctt 3480 ctttcttatc tctctgtgtc tctatttgca cttgagtctc tcacctcagc tcctgtaaaa 3540 gagtggcaag taaaaaacat ggggctctga ttctcctgta attgtgataa ttaaatatac 3600 acacaatcat gacattgaga agaactgcat ttctaccctt aaaaagtact ggtatataca 3660 gaaatagggt taaaaaaaac tcaagctctc tctatatgag accaaaatgt actagagtta 3720 gtttagtgaa ataaaaaacc agtcagctgg ccgggcatgg tggctcatgc ttgtaatccc 3780 agcactttgg gaggccgagg caggtggatc acgaggtcag gagtttgaga ccagtctggc 3840 caacatggtg aaaccccgtc tgtactaaaa atacaaaaat tagctgggcg tggtggtggg 3900 tgcctgtaat cccagctact tgggaggctg aggcaggaga atcgcttgaa cccgggaggt 3960 ggaggtggca gtgagccgag atcacgccac tgcaatgcag cccgggcaac agagctagac 4020 tgtctcaaaa gaacaaaaaa aaaaaaacac aaaaaaactc agtcagcttc ttaaccaatt 4080 gcttccgtgt catccagggc cccattctgt gcagattgag tgtgggcacc acacaggtgg 4140 ttgctgcttc agtgcttcct gctctttttc cttgggcctg cttctgggtt ccatagggaa 4200 acagtaagaa agaaagacac atccttacca taaatgcata tggtccacct acaaatagaa 4260 aaatatttaa atgatctgcc tttatacaaa gtgatattct ctacctttga taatttacct 4320 gcttaaatgt ttttatctgc actgcaaagt actgtatcca aagtaaaatt tcctcatcca 4380 atatctttca aactgttttg ttaactaatg ccatatattt gtaagtatct gcacacttga 4440 tacagcaacg ttagatggtt ttgatggtaa accctaaagg aggactccaa gagtgtgtat 4500 ttatttatag ttttatcaga gatgacaatt atttgaatgc caattatatg gattcctttc 4560 attttttgct ggaggatggg agaagaaacc aaagtttata gaccttcaca ttgagaaagc 4620 ttcagttttg aacttcagct atcagattca aaaacaacag aaagaaccaa gacattctta 4680 agatgcctgt actttcagct gggtataaat tcatgagttc aaagattgaa acctgaccaa 4740 tttgctttat ttcatggaag aagtgatcta caaaggtgtt tgtgccattt ggaaaacagc 4800 gtgcatgtgt tcaagcctta gattggcgat gtcgtatttt cctcacgtgt ggcaatgcca 4860 aaggctttac tttacctgtg agtacacact atatgaatta tttccaacgt acatttaatc 4920 aataagggtc acaaattccc aaatcaatct ctggaataaa tagagaggta attaaattgc 4980 tggagccaac ta 4992 <210> 70 <211> 3134 <212> DNA <213> Homo sapiens CD4 molecule (CD4), transcript variant 1 <400> 70 gtttggggcc ggcccaggcc tagggtgtgg aggagccttg ccatcgggct tcctgtctct 60 cttcatttaa gcacgactct gcagaaggaa caaagcaccc tccccactgg gctcctggtt 120 gcagagctcc aagtcctcac acagatacgc ctgtttgaga agcagcgggc aagaaagacg 180 caagcccaga ggccctgcca tttctgtggg ctcaggtccc tactggctca ggcccctgcc 240 tccctcggca aggccacaat gaaccgggga gtccctttta ggcacttgct tctggtgctg 300 caactggcgc tcctcccagc agccactcag ggaaagaaag tggtgctggg caaaaaaggg 360 gatacagtgg aactgacctg tacagcttcc cagaagaaga gcatacaatt ccactggaaa 420 aactccaacc agataaagat tctgggaaat cagggctcct tcttaactaa aggtccatcc 480 aagctgaatg atcgcgctga ctcaagaaga agcctttggg accaaggaaa ctttcccctg 540 atcatcaaga atcttaagat agaagactca gatacttaca tctgtgaagt ggaggaccag 600 aaggaggagg tgcaattgct agtgttcgga ttgactgcca actctgacac ccacctgctt 660 caggggcaga gcctgaccct gaccttggag agcccccctg gtagtagccc ctcagtgcaa 720 tgtaggagtc caaggggtaa aaacatacag ggggggaaga ccctctccgt gtctcagctg 780 gagctccagg atagtggcac ctggacatgc actgtcttgc agaaccagaa gaaggtggag 840 ttcaaaatag acatcgtggt gctagctttc cagaaggcct ccagcatagt ctataagaaa 900 gagggggaac aggtggagtt ctccttccca ctcgccttta cagttgaaaa gctgacgggc 960 agtggcgagc tgtggtggca ggcggagagg gcttcctcct ccaagtcttg gatcaccttt 1020 gacctgaaga acaaggaagt gtctgtaaaa cgggttaccc aggaccctaa gctccagatg 1080 ggcaagaagc tcccgctcca cctcaccctg ccccaggcct tgcctcagta tgctggctct 1140 ggaaacctca ccctggccct tgaagcgaaa acaggaaagt tgcatcagga agtgaacctg 1200 gtggtgatga gagccactca gctccagaaa aatttgacct gtgaggtgtg gggacccacc 1260 tcccctaagc tgatgctgag tttgaaactg gagaacaagg aggcaaaggt ctcgaagcgg 1320 gagaaggcgg tgtgggtgct gaaccctgag gcggggatgt ggcagtgtct gctgagtgac 1380 tcgggacagg tcctgctgga atccaacatc aaggttctgc ccacatggtc caccccggtg 1440 cagccaatgg ccctgattgt gctggggggc gtcgccggcc tcctgctttt cattgggcta 1500 ggcatcttct tctgtgtcag gtgccggcac cgaaggcgcc aagcagagcg gatgtctcag 1560 atcaagagac tcctcagtga gaagaagacc tgccagtgtc ctcaccggtt tcagaagaca 1620 tgtagcccca tttgaggcac gaggccaggc agatcccact tgcagcctcc ccaggtgtct 1680 gccccgcgtt tcctgcctgc ggaccagatg aatgtagcag atcccaggcc tctggcctcc 1740 tgttcgcctc ctctacaatt tgccattgtt tctcctgggt taggccccgg cttcactggt 1800 tgagtgttgc tctctagttt ccagaggctt aatcacaccg tcctccacgc catttccttt 1860 tccttcaagc ctagcccttc tctcattatt tctctctgac cctctcccca ctgctcattt 1920 ggatcccagg ggagtgttca gggccagccc tggctggcat ggagggtgag gctgggtgtc 1980 tggaagcatg gagcatggga ctgttctttt acaagacagg accctgggac cacagagggc 2040 aggaacttgc acaaaatcac acagccaagc cagtcaagga tggatgcaga tccagaggtt 2100 tctggcagcc agtacctcct gccccatgct gcccgcttct caccctatgt gggtgggacc 2160 acagactcac atcctgacct tgcacaaaca gcccctctgg acacagcccc atgtacacgg 2220 cctcaaggga tgtctcacat cctctgtcta tttgagactt agaaaaatcc tacaaggctg 2280 gcagtgacag aactaagatg atcatctcca gtttatagac cagaaccaga gctcagagag 2340 gctagatgat tgattaccaa gtgccggact agcaagtgct ggagtcggga ctaacccagg 2400 tcccttgtcc caagttccac tgctgcctct tgaatgcagg gacaaatgcc acacggctct 2460 caccagtggc tagtggtggg tactcaatgt gtacttttgg gttcacagaa gcacagcacc 2520 catgggaagg gtccatctca gagaatttac gagcagggat gaaggcctcc ctgtctaaaa 2580 tccctccttc atcccccgct ggtggcagaa tctgttacca gaggacaaag cctttggctc 2640 ttctaatcag agcgcaagct gggagcacag gcactgcagg agagaatgcc cagtgaccag 2700 tcactgaccc tgtgcagaac ctcctggaag cgagctttgc tgggagaggg ggtagctagc 2760 ctgagaggga accctctaag ggacctcaaa ggtgattgtg ccaggctctg cgcctgcccc 2820 acaccctccc ttaccctcct ccagaccatt caggacacag ggaaatcagg gttacaaatc 2880 ttcttgatcc acttctctca ggatcccctc tcttcctacc cttcctcacc acttccctca 2940 gtcccaactc cttttcccta tttccttctc ctcctgtctt taaagcctgc ctcttccagg 3000 aagacccccc tattgctgct ggggctcccc atttgcttac tttgcatttg tgcccactct 3060 ccacccctgc tcccctgagc tgaaataaaa atacaataaa cttactataa agatgcaaaa 3120 aaaaaaaaaa aaaa 3134 <210> 71 <211> 1567 <212> DNA <213> Homo sapiens CD53 molecule (CD53) <400> 71 gtcgtcacag catgatcata ttttttcacc cttcacttct ccttttacac aaatagcccc 60 ggatatctgt gttaccagcc ttgtctcggc cacctcaagg ataatcacta aattctgccg 120 aaaggactga ggaacggtgc ctggaaaagg gcaagaatat cacggcatgg gcatgagtag 180 cttgaaactg ctgaagtatg tcctgttttt cttcaacttg ctcttttgga tctgtggctg 240 ctgcattttg ggctttggga tctacctgct gatccacaac aacttcggag tgctcttcca 300 taacctcccc tccctcacgc tgggcaatgt gtttgtcatc gtgggctcta ttatcatggt 360 agttgccttc ctgggctgca tgggctctat caaggaaaac aagtgtctgc ttatgtcgtt 420 cttcatcctg ctgctgatta tcctccttgc tgaggtgacc ttggccatcc tgctctttgt 480 atatgaacag aagctgaatg agtatgtggc taagggtctg accgacagca tccaccgtta 540 ccactcagac aatagcacca aggcagcgtg ggactccatc cagtcatttc tgcagtgttg 600 tggtataaat ggcacgagtg attggaccag tggcccacca gcatcttgcc cctcagatcg 660 aaaagtggag ggttgctatg cgaaagcaag actgtggttt cattccaatt tcctgtatat 720 cggaatcatc accatctgtg tatgtgtgat tgaggtgttg gggatgtcct ttgcactgac 780 cctgaactgc cagattgaca aaaccagcca gaccataggg ctatgatctg cagtagtcct 840 gtggtgaaga gacttgtttc atctccggaa atgcaaaacc atttatagca tgaagcccta 900 catgatcact gcaggatgat cctcctccca tcctttccct ttttaggtcc ctgtcttata 960 caaccagaga agtgggtgtt ggccaggcac atcccatctc aggcagcaag acaatctttc 1020 actcactgac ggcagcagcc atgtctctca aagtggtgaa actaatatct gagcatcttt 1080 tagacaagag aggcaaagac aaactggatt taatggccca acatcaaagg gtgaacccag 1140 gatatgaatt tttgcatctt cccattgtcg aattagtctc cagcctctaa ataatgccca 1200 gtcttctccc caaagtcaag caagagacta gttgaaggga gttctggggc caggctcact 1260 ggaccattgt cacaaccctc tgtttctctt tgactaagtg ccctggctac aggaattaca 1320 cagttctctt tctccaaagg gcaagatctc atttcaattt ctttattaga gggccttatt 1380 gatgtgttct aagtctttcc agaaaaaaac tatccagtga tttatatcct gatttcaacc 1440 agtcacttag ctgataatca cagtaagaag acttctggta ttatctctct atcagataag 1500 attttgttaa tgtactattt tactcttcaa taaataaaag tttattatct caatcacaac 1560 attgcta 1567 <210> 72 <211> 2472 <212> DNA <213> Homo sapiens lymphocyte cytosolic protein 2 (LCP2) <400> 72 gaagagacca tatttgttcg cagaggaagc cgttgctttc tgggatctgg ctacgccaga 60 aaagacatcg gctccaacag gggtgttcca cagggtagct gggagttgga agagccaaga 120 acgcctccga gctctggatt tgagcttctc tgcccatggg tgaagcgccc atgctcagct 180 tgtgagcttc ttcccgggag agcagccatg gcactgagga atgtgccctt tcgctcagag 240 gtcctgggct gggaccccga cagccttgct gactatttca agaagctcaa ctataaggac 300 tgtgagaagg cagtgaagaa gtaccacatc gatggggctc gcttcttgaa cctgacagaa 360 aatgacatcc agaagttccc caagctccgg gtgccgattc tcagtaagtt aagtcaggaa 420 atcaacaaga acgaagagag gaggagcatc ttcacacgca aaccccaagt cccgcggttt 480 cctgaagaga cagaaagcca cgaagaggac aatgggggct ggtcgtcctt tgaagaagac 540 gattatgaaa gtcccaatga tgaccaggat ggggaggatg atggagacta tgagtccccc 600 aatgaggagg aagaggcacc cgtggaagat gacgcggatt atgagccgcc accctccaat 660 gacgaggaag ctctgcagaa ctccatcctg cctgccaagc ctttccccaa ctccaactcc 720 atgtacatcg accggccccc ctctgggaaa accccccagc agcctcctgt gcccccccag 780 agaccgatgg ccgccctccc gcccccacca gccggccgga atcactcgcc actgccccca 840 ccccagacca accacgaaga acccagcaga agcagaaacc acaaaacggc aaagctccct 900 gctccttcaa tagacagaag cacgaaacct cccctagatc gttcattagc tccgtttgat 960 agagaaccct tcacactagg aaagaaacca ccattttctg acaagccctc gattccagcg 1020 ggaaggtcac tcggggagca tttacccaag attcaaaagc ctcctttacc accgaccacg 1080 gaaagacatg aaaggagcag ccccctgcca gggaagaagc cacctgtgcc aaagcatgga 1140 tggggaccag acagaagaga gaatgatgaa gatgatgtgc atcagagacc tttgccccag 1200 ccagcactac ttcctatgag ctccaacact ttcccttcaa gatctactaa gccaagtccc 1260 atgaaccctc tcccatcctc tcacatgcct ggagcattct cagaaagtaa cagcagtttt 1320 ccacagagtg cctccctgcc accatacttc tctcaaggcc ctagcaacag accacctatc 1380 agagccgaag gcagaaactt ccccttgcca cttccaaaca aacctcggcc cccatccccc 1440 gcggaggaag agaattcatt aaatgaagag tggtacgttt cttatattac ccgaccagag 1500 gcagaagctg ctcttagaaa gataaaccag gatggcacat ttctggtcag agacagctct 1560 aaaaaaacaa caaccaatcc atatgtcctc atggtgttgt acaaagataa agtttacaac 1620 atccagatcc gttatcagaa ggaaagtcaa gtttacttgt tgggaactgg actccgaggg 1680 aaagaggact ttctgtctgt gtcagatatt attgactact tcaggaaaat gccacttctg 1740 ctcattgatg ggaaaaaccg aggttccaga taccagtgca cattaacgca tgctgcaggg 1800 tacccatagc aagttatagc cgagcaaatg aaccgtcctc ctgcctctgt tgccaacacg 1860 agatcaatca gccttggtca atggacaaac acttaggact gaactgaacc cctccccatg 1920 aacacaaggg ttttatcctt tcctttaaaa acagtgtttg aaatgaagac tgtcaactat 1980 cccataattt atttattctt cttcaatgtt tgtaaagtgc atgagtcatg ttcacacttg 2040 aagtctagta gtgcactgta ataattcatt ttttaaaaga ttatttaatg cccatttcaa 2100 aatacagtag tttacacagc tacagaaaca atttggggca agttttaaaa cactgaaaca 2160 gtaatagtta ttggtgtcac ataaaactga tttgtttttt acagccaaac ctctgtcagt 2220 cagaggcatt cattagtttt atacatgtaa tttgaaaatc actaaacctc gttttctcag 2280 cagcaataat ttaagaggct tcaaaaatat aatttcactc ttatttagta ttttttcctg 2340 ggggcatttt tacgtaattt ttttatgaaa agacaaatgc atgttgagat aacttctggg 2400 attaaaatag tcttttgctt taaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 2460 aaaaaaaaaa aa 2472 <210> 73 <211> 1058 <212> DNA <213> Homo sapiens immunoglobulin superfamily, member 6 (IGSF6) <400> 73 aagccaactt tcctttcaaa tacacacccc aacccgcccc ggcatacaca gaaatgggga 60 ctgcgagcag aagcaacatc gctcgccatc tgcaaaccaa tctcattcta ttttgtgtcg 120 gtgctgtggg cgcctgtact ctctctgtca cacaaccgtg gtacctagaa gtggactaca 180 ctcatgaggc cgtcaccata aagtgtacct tctccgcaac cggatgccct tctgagcaac 240 caacatgcct gtggtttcgc tacggtgctc accagcctga gaacctgtgc ttggacgggt 300 gcaaaagtga ggcagacaag ttcacagtga gggaggccct caaagaaaac caagtttccc 360 tcactgtaaa cagagtgact tcaaatgaca gtgcaattta catctgtgga atagcattcc 420 ccagtgtgcc ggaagcgaga gctaaacaga caggaggagg gaccacactg gtggtaagag 480 aaattaagct gctcagcaag gaactgcgga gcttcctgac agctcttgta tcactgctct 540 ctgtctatgt gaccggtgtg tgcgtggcct tcatactcct ctccaaatca aaatccaacc 600 ctctaagaaa caaagaaata aaagaagact cacaaaagaa gaagagtgct cggcgtattt 660 ttcaggaaat tgctcaagaa ctataccata agagacatgt ggaaacaaat cagcaatctg 720 agaaagataa caacacttat gaaaacagaa gagtactttc caactatgaa aggccataga 780 aacgttttaa ttttcaatga agtcactgaa aatccaactc caggagctat ggcagtgtta 840 atgaacatat atcatcaggt cttaaaaaaa aataaaggta aactgaaaag acaactggct 900 acaaagaagg atgtcagaat gtaaggaaac tataactaat agtcattacc aaaatactaa 960 aacccaacaa aatgcaactg aaaaatacct tccaaatttg ccaagaaaaa aaattctatt 1020 ttaaacttaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa 1058 <210> 74 <211> 2775 <212> DNA <213> Homo sapiens glycoprotein (transmembrane) nmb (GPNMB) <400> 74 tgccgcttaa taccatcaca tgatcctccc cgaggccctg tatttaatta aaatagagag 60 ggaggcacca cagatgccag aagaacactg ttgctcttgg tggacgggcc cagaggaatt 120 cagagttaaa ccttgagtgc ctgcgtccgt gagaattcag catggaatgt ctctactatt 180 tcctgggatt tctgctcctg gctgcaagat tgccacttga tgccgccaaa cgatttcatg 240 atgtgctggg caatgaaaga ccttctgctt acatgaggga gcacaatcaa ttaaatggct 300 ggtcttctga tgaaaatgac tggaatgaaa aactctaccc agtgtggaag cggggagaca 360 tgaggtggaa aaactcctgg aagggaggcc gtgtgcaggc ggtcctgacc agtgactcac 420 cagccctcgt gggctcaaat ataacatttg cggtgaacct gatattccct agatgccaaa 480 aggaagatgc caatggcaac atagtctatg agaagaactg cagaaatgag gctggtttat 540 ctgctgatcc gtatgtttac aactggacag catggtcaga ggacagtgac ggggaaaatg 600 gcaccggcca aagccatcat aacgtcttcc ctgatgggaa accttttcct caccaccccg 660 gatggagaag atggaatttc atctacgtct tccacacact tggtcagtat ttccagaaat 720 tgggacgatg ttcagtgaga gtttctgtga acacagccaa tgtgacactt gggcctcaac 780 tcatggaagt gactgtctac agaagacatg gacgggcata tgttcccatc gcacaagtga 840 aagatgtgta cgtggtaaca gatcagattc ctgtgtttgt gactatgttc cagaagaacg 900 atcgaaattc atccgacgaa accttcctca aagatctccc cattatgttt gatgtcctga 960 ttcatgatcc tagccacttc ctcaattatt ctaccattaa ctacaagtgg agcttcgggg 1020 ataatactgg cctgtttgtt tccaccaatc atactgtgaa tcacacgtat gtgctcaatg 1080 gaaccttcag ccttaacctc actgtgaaag ctgcagcacc aggaccttgt ccgccaccgc 1140 caccaccacc cagaccttca aaacccaccc cttctttagc aactactcta aaatcttatg 1200 attcaaacac cccaggacct gctggtgaca accccctgga gctgagtagg attcctgatg 1260 aaaactgcca gattaacaga tatggccact ttcaagccac catcacaatt gtagagggaa 1320 tcttagaggt taacatcatc cagatgacag acgtcctgat gccggtgcca tggcctgaaa 1380 gctccctaat agactttgtc gtgacctgcc aagggagcat tcccacggag gtctgtacca 1440 tcatttctga ccccacctgc gagatcaccc agaacacagt ctgcagccct gtggatgtgg 1500 atgagatgtg tctgctgact gtgagacgaa ccttcaatgg gtctgggacg tactgtgtga 1560 acctcaccct gggggatgac acaagcctgg ctctcacgag caccctgatt tctgttcctg 1620 acagagaccc agcctcgcct ttaaggatgg caaacagtgc cctgatctcc gttggctgct 1680 tggccatatt tgtcactgtg atctccctct tggtgtacaa aaaacacaag gaatacaacc 1740 caatagaaaa tagtcctggg aatgtggtca gaagcaaagg cctgagtgtc tttctcaacc 1800 gtgcaaaagc cgtgttcttc ccgggaaacc aggaaaagga tccgctactc aaaaaccaag 1860 aatttaaagg agtttcttaa atttcgacct tgtttctgaa gctcactttt cagtgccatt 1920 gatgtgagat gtgctggagt ggctattaac ctttttttcc taaagattat tgttaaatag 1980 atattgtggt ttggggaagt tgaatttttt ataggttaaa tgtcatttta gagatgggga 2040 gagggattat actgcaggca gcttcagcca tgttgtgaaa ctgataaaag caacttagca 2100 aggcttcttt tcattatttt ttatgtttca cttataaagt cttaggtaac tagtaggata 2160 gaaacactgt gtcccgagag taaggagaga agctactatt gattagagcc taacccaggt 2220 taactgcaag aagaggcggg atactttcag ctttccatgt aactgtatgc ataaagccaa 2280 tgtagtccag tttctaagat catgttccaa gctaactgaa tcccacttca atacacactc 2340 atgaactcct gatggaacaa taacaggccc aagcctgtgg tatgatgtgc acacttgcta 2400 gactcagaaa aaatactact ctcataaatg ggtgggagta ttttggtgac aacctacttt 2460 gcttggctga gtgaaggaat gatattcata tattcattta ttccatggac atttagttag 2520 tgctttttat ataccaggca tgatgctgag tgacactctt gtgtatattt ccaaattttt 2580 gtacagtcgc tgcacatatt tgaaatcata tattaagact ttccaaagat gaggtccctg 2640 gtttttcatg gcaacttgat cagtaaggat ttcacctctg tttgtaacta aaaccatcta 2700 ctatatgtta gacatgacat tctttttctc tccttcctga aaaataaagt gtgggaagag 2760 acaagaaaaa aaaaa 2775 <210> 75 <211> 4353 <212> DNA <213> Homo sapiens cytochrome b-245, beta polypeptide (CYBB) <400> 75 attggaagaa gaagcatagt atagaagaaa ggcaaacaca acacattcaa cctctgccac 60 catggggaac tgggctgtga atgaggggct ctccattttt gtcattctgg tttggctggg 120 gttgaacgtc ttcctctttg tctggtatta ccgggtttat gatattccac ctaagttctt 180 ttacacaaga aaacttcttg ggtcagcact ggcactggcc agggcccctg cagcctgcct 240 gaatttcaac tgcatgctga ttctcttgcc agtctgtcga aatctgctgt ccttcctcag 300 gggttccagt gcgtgctgct caacaagagt tcgaagacaa ctggacagga atctcacctt 360 tcataaaatg gtggcatgga tgattgcact tcactctgcg attcacacca ttgcacatct 420 atttaatgtg gaatggtgtg tgaatgcccg agtcaataat tctgatcctt attcagtagc 480 actctctgaa cttggagaca ggcaaaatga aagttatctc aattttgctc gaaagagaat 540 aaagaaccct gaaggaggcc tgtacctggc tgtgaccctg ttggcaggca tcactggagt 600 tgtcatcacg ctgtgcctca tattaattat cacttcctcc accaaaacca tccggaggtc 660 ttactttgaa gtcttttggt acacacatca tctctttgtg atcttcttca ttggccttgc 720 catccatgga gctgaacgaa ttgtacgtgg gcagaccgca gagagtttgg ctgtgcataa 780 tataacagtt tgtgaacaaa aaatctcaga atggggaaaa ataaaggaat gcccaatccc 840 tcagtttgct ggaaaccctc ctatgacttg gaaatggata gtgggtccca tgtttctgta 900 tctctgtgag aggttggtgc ggttttggcg atctcaacag aaggtggtca tcaccaaggt 960 ggtcactcac cctttcaaaa ccatcgagct acagatgaag aagaaggggt tcaaaatgga 1020 agtgggacaa tacatttttg tcaagtgccc aaaggtgtcc aagctggagt ggcacccttt 1080 tacactgaca tccgcccctg aggaagactt ctttagtatc catatccgca tcgttgggga 1140 ctggacagag gggctgttca atgcttgtgg ctgtgataag caggagtttc aagatgcgtg 1200 gaaactacct aagatagcgg ttgatgggcc ctttggcact gccagtgaag atgtgttcag 1260 ctatgaggtg gtgatgttag tgggagcagg gattggggtc acacccttcg catccattct 1320 caagtcagtc tggtacaaat attgcaataa cgccaccaat ctgaagctca aaaagatcta 1380 cttctactgg ctgtgccggg acacacatgc ctttgagtgg tttgcagatc tgctgcaact 1440 gctggagagc cagatgcagg aaaggaacaa tgccggcttc ctcagctaca acatctacct 1500 cactggctgg gatgagtctc aggccaatca ctttgctgtg caccatgatg aggagaaaga 1560 tgtgatcaca ggcctgaaac aaaagacttt gtatggacgg cccaactggg ataatgaatt 1620 caagacaatt gcaagtcaac accctaatac cagaatagga gttttcctct gtggacctga 1680 agccttggct gaaaccctga gtaaacaaag catctccaac tctgagtctg gccctcgggg 1740 agtgcatttc attttcaaca aggaaaactt ctaacttgtc tcttccatga ggaaataaat 1800 gtgggttgtg ctgccaaatg ctcaaataat gctaattgat aatataaata ccccctgctt 1860 aaaaatggac aaaaagaaac tataatgtaa tggttttccc ttaaaggaat gtcaaagatt 1920 gtttgatagt gataagttac atttatgtgg agctctatgg ttttgagagc acttttacaa 1980 acattatttc atttttttcc tctcagtaat gtcagtggaa gttagggaaa agattcttgg 2040 actcaatttt agaatcaaaa gggaaaggat caaaaggttc agtaacttcc ctaagattat 2100 gaaactgtga ccagatctag cccatcttac tccaggtttg atactctttc cacaatactg 2160 agctgcctca gaatcctcaa aatcagtttt tatattcccc aaaagaagaa ggaaaccaag 2220 gagtagctat atatttctac tttgtgtcat ttttgccatc attattatca tactgaagga 2280 aattttccag atcattagga cataatacat gttgagagtg tctcaacact tattagtgac 2340 agtattgaca tctgagcata ctccagttta ctaatacagc agggtaactg ggccagatgt 2400 tctttctaca gaagaatatt ggattgattg gagttaatgt aatactcatc atttaccact 2460 gtgcttggca gagagcggat actcaagtaa gttttgttaa atgaatgaat gaatttagaa 2520 ccacacaatg ccaagataga attaatttaa agccttaaac aaaatttatc taaagaaata 2580 acttctatta ctgtcataga ccaaaggaat ctgattctcc ctagggtcaa gaacaggcta 2640 aggatactaa ccaataggat tgcctgaagg gttctgcaca ttcttatttg aagcatgaaa 2700 aaagagggtt ggaggtggag aattaacctc ctgccatgac tctggctcat ctagtcctgc 2760 tccttgtgct ataaaataaa tgcagactaa tttcctgccc aaagtggtct tctccagcta 2820 gcccttatga atattgaact taggaattgt gacaaatatg tatctgatat ggtcatttgt 2880 tttaaataac acccacccct tattttccgt aaatacacac acaaaatgga tcgcatctgt 2940 gtgactaatg gtttatttgt attatatcat catcatcatc ctaaaattaa caacccagaa 3000 acaaaaatct ctatacagag atcaaattca cactcaatag tatgttctga atatatgttc 3060 aagagagagt ctctaaatca ctgttagtgt ggccaagagc agggttttct ttttgttctt 3120 agaactgctc ccatttctgg gaactaaaac cagttttatt tgccccaccc cttggagcca 3180 caaatgttta gaactcttca acttcggtaa tgaggaagaa ggagaaagag ctgggggaag 3240 ggcagaagac tggtttagga ggaaaaggaa ataaggagaa aagagaatgg gagagtgaga 3300 gaaaataaaa aaggcaaaag ggagagagag gggaaggggg tctcatattg gtcattccct 3360 gccccagatt tcttaaagtt tgatatgtat agaatataat tgaaggaggt atacacatat 3420 tgatgttgtt ttgattatct atggtattga atcttttaaa atctggtcac aaattttgat 3480 gctgaggggg attattcaag ggactaggat gaactaaata agaactcagt tgttctttgt 3540 catactacta ttcctttcgt ctcccagaat cctcagggca ctgagggtag gtctgacaaa 3600 taaggcctgc tgtgcgaata tagcctttct gaaatgtacc aggatggttt ctgcttagag 3660 acacttaggt ccagcctgtt cacactgcac ctcaggtatc aattcatcta ttcaacagat 3720 atttattgtg ttattactat gagtcaggct ctgtttattg tttcaattct ttacaccaaa 3780 gtatgaactg gagagggtac ctcagttata aggagtctga gaatattggc cctttctaac 3840 ctatgtgcat aattaaaacc agcttcattt gttgctccga gagtgtttct ccaaggtttt 3900 ctatcttcaa aaccaactaa gttatgaaag tagagagatc tgccctgtgt tatccagtta 3960 tgagataaaa aatgaatata agagtgcttg tcattataaa agtttccttt tttattctct 4020 caagccacca gctgccagcc accagcagcc agctgccagc ctagcttttt tttttttttt 4080 ttttttttag cacttagtat ttagcattta ttaacaggta ctctaagaat gatgaagcat 4140 tgtttttaat cttaagacta tgaaggtttt tcttagttct tctgcttttg caattgtgtt 4200 tgtgaaattt gaatacttgc aggctttgta tgtgaataat tctagcgggg gacctgggag 4260 ataattccta cggggaattc ttaaaactgt gctcaactat taaaatgaat gagctttcaa 4320 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa 4353 <210> 76 <211> 4481 <212> DNA <213> Homo sapiens CD96 molecule (CD96) <400> 76 ttcctgtcta cgtttcattt cctgggggct tgccaagtga taaacagacc caggcgtgtg 60 tggtagagtt cgggtttttt agcacgaagt gggtggctgg agtttgcttg aaaacatcaa 120 ttgactttgt gatcattaca gaaatgctgg tgtaaggtgt tcagaagaca atggagaaaa 180 aatggaaata ctgtgctgtc tattacatca tccagataca ttttgtcaag ggagtttggg 240 aaaaaacagt caacacagaa gaaaatgttt atgctacact tggctctgat gtcaacctga 300 cctgccaaac acagacagta ggcttcttcg tgcagatgca atggtccaag gtcaccaata 360 agatagacct gattgctgtc tatcatcccc aatacggctt ctactgtgcc tatgggagac 420 cctgtgagtc acttgtgact ttcacagaaa ctcctgagaa tgggtcaaaa tggactctgc 480 acttaaggaa tatgtcttgt tcagtcagtg gaaggtacga gtgtatgctt gttctgtatc 540 cagagggcat tcagactaaa atctacaacc ttctcattca gacacacgtt acagcagatg 600 aatggaacag caaccatacg atagaaatag agataaatca gactctggaa ataccatgct 660 ttcaaaatag ctcctcaaaa atttcatctg agttcaccta tgcatggtcg gtggaaaaca 720 gcagcacgga ttcttgggtc cttctttcta agggtataaa ggaggataat ggaactcagg 780 aaacacttat ctcccaaaat cacctcatca gcaattccac attacttaaa gatagagtca 840 agcttggtac agactacaga ctccacctct ctccagtcca aatcttcgat gatgggcgga 900 agttctcttg ccacattaga gtcggtccta acaaaatctt gaggagctcc accacagtca 960 aggtttttgc taaaccagaa atccctgtga ttgtggaaaa taactccacg gatgtcttgg 1020 tagagagaag atttacctgc ttactaaaga atgtatttcc caaagcaaat atcacatggt 1080 ttatagatgg aagttttctt catgatgaaa aagaaggaat atatattact aatgaagaga 1140 gaaaaggcaa agatggattt ttggaactga agtctgtttt aacaagggta catagtaata 1200 aaccagccca atcagacaac ttgaccattt ggtgtatggc tctgtctcca gtcccaggaa 1260 ataaagtgtg gaacatctca tcagaaaaga tcacttttct cttaggttct gaaatttcct 1320 caacagaccc tccactgagt gttacagaat ctacccttga cacccaacct tctccagcca 1380 gcagtgtatc tcctgcaaga tatccagcta catcttcagt gacccttgta gatgtgagtg 1440 ccttgaggcc aaacaccact cctcaaccca gcaattccag tatgactacc cgaggcttca 1500 actatccctg gacctccagt gggacagata ccaaaaaatc agtttcacgg atacctagtg 1560 aaacatacag ttcatccccg tcaggtgcag gctcaacact tcatgacaat gtctttacca 1620 gcacagccag agcattttca gaagtcccca caactgccaa tggatctacg aaaactaatc 1680 acgtccatat cactggtatt gtggtcaata agcccaaaga tggaatgtcc tggccagtga 1740 ttgtagcagc tttactcttt tgctgcatga tattgtttgg tcttggagtg agaaaatggt 1800 gtcagtacca aaaagaaata atggaaagac ctccaccttt caagccacca ccacctccca 1860 tcaagtacac ttgcattcaa gagcccaacg aaagtgatct gccttatcat gagatggaga 1920 ccctctagtc tcgtgagact ttgccccatg gcagaactct gctggaatcc tattgagaag 1980 gtagacattg tgctttatta atatagtcgc tcttcagcca tgcctttgct gcagctgaaa 2040 tggaagtcag aagtgagtga cctgttttcc cagcaactca ccctcttcca tctccaaacg 2100 cctgaagctt aaccaagagt gagaggatat gtcatgttca cactcaatgc aattcgtagt 2160 ggttttcttg cttatgtaag aagtacatat tagtctgcca tctttaaaaa aaaatacagt 2220 attttcattt aaattctctg atggagggac aacaatggtt tcaactgtat gcccatgcct 2280 gatcctctta tttgaacatc tatcaacatt gtaaactctt tgccaaaatc ctggggcttt 2340 gctgcattcc ctaagataat tacaggaaaa agaaaatgta aaagtgctaa caaggctgcc 2400 aagtaatgga gaagtatggt tagtcttcat attgaaattc tgttgcttat tttcatggaa 2460 ggaaacagaa tactttgcac aggaaccaca ttttcaatcc tccttcactg tcttcctacc 2520 atgttcagcc cagactcctg ccacatggac caggatgaag agggatcaaa gagataatta 2580 gccaaaaacc cagtagccta gaagatacaa aactccactg gcctctaaaa ttatattagc 2640 caagagtggt ttcatttgag tgccttcgtg tgtatgtcca tcaaactgga accaaactgt 2700 tttgtaagta aacaggcagc ctaagcccaa ccctactttc taattccagt tattctcttt 2760 ttcatctggg gatttacctg ttcatttaat ctgcctgttt tgatctgttt tgaaaaagat 2820 aaagagcctc aaatcagacc agcactgatt aattaaccct gctcctacca atctttttta 2880 aagcagttga agcagaatgt ataggtgtca gagaagaaac ctagtcagcc agacgtgctc 2940 tgtattcagc aatagtttgt gaatgaataa attactaatc ctccttgtcg cttgaaacct 3000 tcccacactc cctgctccag gagggaaaaa cagatgttgt tgacagatag agtgataggc 3060 aaattctgtg tggactttag tcccaaaagg aaactttagt tcacttgcag tatgcttatc 3120 cttgactgca catgagaatg ccttgtgcag agttatttgg agattatgtc tttttcttaa 3180 acaccatggc tgtcacactt cagttcaatt aaatcagaat gtctgaggag tgagacacag 3240 gcatcaacac tctcaaatga ttcacatgtt cagccaaagt tgagaaccat cgagcctgtg 3300 gaagttcttt ctcatggctc agaatcttag gtaggtgctt aactcttgtg gtggccagcc 3360 tccaagatga gccccagtgt tcttgcctcc tactattcac atctttatgt ggtcccctcc 3420 aatgctgaat acagatgatt tgtgtaacct gaggccagga ttaaggggag gcaatcaatg 3480 cacctaggga aaaaatttaa ggaggtattc acactcaggg tcatgcactt gcacaatgtt 3540 gagaatgagt accactctca ccattggtat agccaaaaaa gcttggaagt gaccaaggct 3600 aggtcacaaa atacactgtg gcttcttctt tgatctctct ttgaccatac tgacactggg 3660 aaaagcccat tcccatgcca tgaagacacc aaggcagccc tattgagaaa tctacctgtc 3720 gtggccgggc gcagtggctc acgcctgtaa tcccagcact ttgggaggcc gaggtgggtg 3780 gatcacgagg tcaggagatc gagaccatcc tggctaacac agtgaaaccc cgtctctact 3840 aaaaatacaa aaaattagcc gggtgtggtg tcgggcacct gtagtcccag ctactcagga 3900 ggctgaggca ggagaagggt gggaacccgg gaggcagagc ttgcagtgag ccgagattgt 3960 gccactgcac actccaatct gggtgaaaga ccgagactcc gcctcaaaaa aaaaaaaaaa 4020 agaaagaaag aaagaaagaa agaaatctac ctgtcaagga actaaggtat tttgctaaca 4080 agcaccaact tgccagccat gtaagggagc catcttggaa gcagatcctc cagcctccag 4140 tcaagtcttc agataattgc aacttcagtt gatcttttga ccaagacctc aagagagcca 4200 gaactaccca gctaagcctt ttactaaatt tctgaacttc taacactatt agataataag 4260 tgcttattgt ttaacaccat taattttgag tataatttgt tacatagcga cagataacta 4320 tacagctcaa caactagaaa aataaactgt ttacctgcct taattattta tctttagttc 4380 cttattagtt ctcaagaaac aaatgctagc ttcatatgta tggctgttgc tttgcttcat 4440 gtgtatggct atttgtattt aacaagactt aatcatcagt a 4481 <210> 77 <211> 3672 <212> DNA <213> Homo sapiens interleukin 10 receptor, alpha (IL10RA) <400> 77 gtcagtccca gcccaagggt agctggaggc gcgcaggccg gctccgctcc ggccccggac 60 gatgcggcgc gcccaggatg ctgccgtgcc tcgtagtgct gctggcggcg ctcctcagcc 120 tccgtcttgg ctcagacgct catgggacag agctgcccag ccctccgtct gtgtggtttg 180 aagcagaatt tttccaccac atcctccact ggacacccat cccaaatcag tctgaaagta 240 cctgctatga agtggcgctc ctgaggtatg gaatagagtc ctggaactcc atctccaact 300 gtagccagac cctgtcctat gaccttaccg cagtgacctt ggacctgtac cacagcaatg 360 gctaccgggc cagagtgcgg gctgtggacg gcagccggca ctccaactgg accgtcacca 420 acacccgctt ctctgtggat gaagtgactc tgacagttgg cagtgtgaac ctagagatcc 480 acaatggctt catcctcggg aagattcagc tacccaggcc caagatggcc cccgcaaatg 540 acacatatga aagcatcttc agtcacttcc gagagtatga gattgccatt cgcaaggtgc 600 cgggaaactt cacgttcaca cacaagaaag taaaacatga aaacttcagc ctcctaacct 660 ctggagaagt gggagagttc tgtgtccagg tgaaaccatc tgtcgcttcc cgaagtaaca 720 aggggatgtg gtctaaagag gagtgcatct ccctcaccag gcagtatttc accgtgacca 780 acgtcatcat cttctttgcc tttgtcctgc tgctctccgg agccctcgcc tactgcctgg 840 ccctccagct gtatgtgcgg cgccgaaaga agctacccag tgtcctgctc ttcaagaagc 900 ccagcccctt catcttcatc agccagcgtc cctccccaga gacccaagac accatccacc 960 cgcttgatga ggaggccttt ttgaaggtgt ccccagagct gaagaacttg gacctgcacg 1020 gcagcacaga cagtggcttt ggcagcacca agccatccct gcagactgaa gagccccagt 1080 tcctcctccc tgaccctcac ccccaggctg acagaacgct gggaaacagg gagccccctg 1140 tgctggggga cagctgcagt agtggcagca gcaatagcac agacagcggg atctgcctgc 1200 aggagcccag cctgagcccc agcacagggc ccacctggga gcaacaggtg gggagcaaca 1260 gcaggggcca ggatgacagt ggcattgact tagttcaaaa ctctgagggc cgggctgggg 1320 acacacaggg tggctcggcc ttgggccacc acagtccccc ggagcctgag gtgcctgggg 1380 aagaagaccc agctgctgtg gcattccagg gttacctgag gcagaccaga tgtgctgaag 1440 agaaggcaac caagacaggc tgcctggagg aagaatcgcc cttgacagat ggccttggcc 1500 ccaaattcgg gagatgcctg gttgatgagg caggcttgca tccaccagcc ctggccaagg 1560 gctatttgaa acaggatcct ctagaaatga ctctggcttc ctcaggggcc ccaacgggac 1620 agtggaacca gcccactgag gaatggtcac tcctggcctt gagcagctgc agtgacctgg 1680 gaatatctga ctggagcttt gcccatgacc ttgcccctct aggctgtgtg gcagccccag 1740 gtggtctcct gggcagcttt aactcagacc tggtcaccct gcccctcatc tctagcctgc 1800 agtcaagtga gtgactcggg ctgagaggct gcttttgatt ttagccatgc ctgctcctct 1860 gcctggacca ggaggagggc ccctggggca gaagttaggc acgaggcagt ctgggcactt 1920 ttctgcaagt ccactggggc tggccccagc caggccctgc agggctggtc agggtgtctg 1980 gggcaggagg aggccaactc actgaactag tgcagggtat gtgggtggca ctgacctgtt 2040 ctgttgactg gggccctgca gactctggca gagctgagaa gggcagggac cttctccctc 2100 ctaggaactc tttcctgtat cataaaggat tatttgctca ggggaaccat ggggctttct 2160 ggagttgtgg tgaggccacc aggctgaagt cagctcagac ccagacctcc ctgcttaggc 2220 cactcgagca tcagagcttc cagcaggagg aagggctgta ggaatggaag cttcagggcc 2280 ttgctgctgg ggtcattttt aggggaaaaa ggaggatatg atggtcacat ggggaacctc 2340 ccctcatcgg gcctctgggg caggaagctt gtcactggaa gatcttaagg tatatatttt 2400 ctggacactc aaacacatca taatggattc actgagggga gacaaaggga gccgagaccc 2460 tggatggggc ttccagctca gaacccatcc ctctggtggg tacctctggc acccatctgc 2520 aaatatctcc ctctctccaa caaatggagt agcatccccc tggggcactt gctgaggcca 2580 agccactcac atcctcactt tgctgcccca ccatcttgct gacaacttcc agagaagcca 2640 tggttttttg tattggtcat aactcagccc tttgggcggc ctctgggctt gggcaccagc 2700 tcatgccagc cccagagggt cagggttgga ggcctgtgct tgtgtttgct gctaatgtcc 2760 agctacagac ccagaggata agccactggg cactgggctg gggtccctgc cttgttggtg 2820 ttcagctgtg tgattttgga ctagccactt gtcagagggc ctcaatctcc catctgtgaa 2880 ataaggactc cacctttagg ggaccctcca tgtttgctgg gtattagcca agctggtcct 2940 gggagaatgc agatactgtc cgtggactac caagctggct tgtttcttat gccagaggct 3000 aacagatcca atgggagtcc atggtgtcat gccaagacag tatcagacac agccccagaa 3060 gggggcatta tgggccctgc ctccccatag gccatttgga ctctgccttc aaacaaaggc 3120 agttcagtcc acaggcatgg aagctgtgag gggacaggcc tgtgcgtgcc atccagagtc 3180 atctcagccc tgcctttctc tggagcattc tgaaaacaga tattctggcc cagggaatcc 3240 agccatgacc cccacccctc tgccaaagta ctcttaggtg ccagtctggt aactgaactc 3300 cctctggagg caggcttgag ggaggattcc tcagggttcc cttgaaagct ttatttattt 3360 attttgttca tttatttatt ggagaggcag cattgcacag tgaaagaatt ctggatatct 3420 caggagcccc gaaattctag ctctgacttt gctgtttcca gtggtatgac cttggagaag 3480 tcacttatcc tcttggagcc tcagtttcct catctgcaga ataatgactg acttgtctaa 3540 ttcgtaggga tgtgaggttc tgctgaggaa atgggtatga atgtgccttg aacacaaagc 3600 tctgtcaata agtgatacat gttttttatt ccaataaatt gtcaagacca caggaaaaaa 3660 aaaaaaaaaa aa 3672 <210> 78 <211> 2568 <212> DNA <213> Homo sapiens arachidonate 5-lipoxygenase (ALOX5) <400> 78 gccagggacc agtggtggga ggaggctgcg gcgctagatg cggacacctg gaccgccgcg 60 ccgaggctcc cggcgctcgc tgctcccgcg gcccgcgcca tgccctccta cacggtcacc 120 gtggccactg gcagccagtg gttcgccggc actgacgact acatctacct cagcctcgtg 180 ggctcggcgg gctgcagcga gaagcacctg ctggacaagc ccttctacaa cgacttcgag 240 cgtggcgcgg tggattcata cgacgtgact gtggacgagg aactgggcga gatccagctg 300 gtcagaatcg agaagcgcaa gtactggctg aatgacgact ggtacctgaa gtacatcacg 360 ctgaagacgc cccacgggga ctacatcgag ttcccctgct accgctggat caccggcgat 420 gtcgaggttg tcctgaggga tggacgcgca aagttggccc gagatgacca aattcacatt 480 ctcaagcaac accgacgtaa agaactggaa acacggcaaa aacaatatcg atggatggag 540 tggaaccctg gcttcccctt gagcatcgat gccaaatgcc acaaggattt accccgtgat 600 atccagtttg atagtgaaaa aggagtggac tttgttctga attactccaa agcgatggag 660 aacctgttca tcaaccgctt catgcacatg ttccagtctt cttggaatga cttcgccgac 720 tttgagaaaa tctttgtcaa gatcagcaac actatttctg agcgggtcat gaatcactgg 780 caggaagacc tgatgtttgg ctaccagttc ctgaatggct gcaaccctgt gttgatccgg 840 cgctgcacag agctgcccga gaagctcccg gtgaccacgg agatggtaga gtgcagcctg 900 gagcggcagc tcagcttgga gcaggaggtc cagcaaggga acattttcat cgtggacttt 960 gagctgctgg atggcatcga tgccaacaaa acagacccct gcacactcca gttcctggcc 1020 gctcccatct gcttgctgta taagaacctg gccaacaaga ttgtccccat tgccatccag 1080 ctcaaccaaa tcccgggaga tgagaaccct attttcctcc cttcggatgc aaaatacgac 1140 tggcttttgg ccaaaatctg ggtgcgttcc agtgacttcc acgtccacca gaccatcacc 1200 caccttctgc gaacacatct ggtgtctgag gtttttggca ttgcaatgta ccgccagctg 1260 cctgctgtgc accccatttt caagctgctg gtggcacacg tgagattcac cattgcaatc 1320 aacaccaagg cccgtgagca gctcatctgc gagtgtggcc tctttgacaa ggccaacgcc 1380 acagggggcg gtgggcacgt gcagatggtg cagagggcca tgaaggacct gacctatgcc 1440 tccctgtgct ttcccgaggc catcaaggcc cggggcatgg agagcaaaga agacatcccc 1500 tactacttct accgggacga cgggctcctg gtgtgggaag ccatcaggac gttcacggcc 1560 gaggtggtag acatctacta cgagggcgac caggtggtgg aggaggaccc ggagctgcag 1620 gacttcgtga acgatgtcta cgtgtacggc atgcggggcc gcaagtcctc aggcttcccc 1680 aagtcggtca agagccggga gcagctgtcg gagtacctga ccgtggtgat cttcaccgcc 1740 tccgcccagc acgccgcggt caacttcggc cagtacgact ggtgctcctg gatccccaat 1800 gcgcccccaa ccatgcgagc cccgccaccg actgccaagg gcgtggtgac cattgagcag 1860 atcgtggaca cgctgcccga ccgcggccgc tcctgctggc atctgggtgc agtgtgggcg 1920 ctgagccagt tccaggaaaa cgagctgttc ctgggcatgt acccagaaga gcattttatc 1980 gagaagcctg tgaaggaagc catggcccga ttccgcaaga acctcgaggc cattgtcagc 2040 gtgattgctg agcgcaacaa gaagaagcag ctgccatatt actacttgtc cccagaccgg 2100 attccgaaca gtgtggccat ctgagcacac tgccagtctc actgtgggaa ggccagctgc 2160 cccagccaga tggactccag cctgcctggc aggctgtctg gccaggcctc ttggcagtca 2220 catctcttcc tccgaggcca gtacctttcc atttattctt tgatcttcag ggaactgcat 2280 agattgatca aagtgtaaac accataggga cccattctac acagagcagg actgcacagc 2340 gtcctgtcca cacccagctc agcatttcca caccaagcag caacagcaaa tcacgaccac 2400 tgatagatgt ctattcttgt tggagacatg ggatgattat tttctgttct atttgtgctt 2460 agtccaattc cttgcacata gtaggtaccc aattcaatta ctattgaatg aattaagaat 2520 tggttgccat aaaaataaat cagttcattt aaaaaaaaaa aaaaaaaa 2568 <210> 79 <211> 2957 <212> DNA <213> Homo sapiens Rho GTPase activating protein 25 (ARHGAP25) <400> 79 ccgagccttc agagtgaggc attattttct cctctctctt gtcagatact gactcccacg 60 caggaaaaag gaagcacctt ttgtcagatg ctgtggccac ttcctcttca gaaggctcca 120 gccaaccttt cggtttgcag aatgacgggg cccgccgcgg tgccggactg cctgtgcacg 180 gggccaccga ctgcagcctg ggttttattc ttggcctggc cctgaccggg agctggcccc 240 tcggctgctt ctctggctcg ggggggactt tctctggctc agatccggac ccctgaactg 300 gacctggttg tcgtcccccc gcttctcagc cccctctggg gttcctctct cctctccgcc 360 cactctttgc tcactgcccc atgtccctcg gtcagtcggc ctgtctgttc ctctctatag 420 ctcggtcaag gagtgtgatg actggcgagc agatggctgc cttccatcca tcgtccaccc 480 ccaacccgct ggagaggccc atcaagatgg gctggctgaa gaagcagagg tccatcgtga 540 agaactggca gcagaggtac tttgtgctga gggcgcagca gctctactac tacaaggatg 600 aagaggacac gaagccccag ggctgcatgt atctaccagg atgtacaatc aaggagatcg 660 ccacaaaccc agaagaagct gggaagtttg tctttgaaat cattccagcc tcatgggacc 720 agaatcgcat gggacaggac tcctatgtcc tcatggccag ctctcaggcg gagatggagg 780 agtgggttaa attcctcagg agagttgctg gcacaccctg tggagtgttt ggccagcgct 840 tggatgagac tgtggcctat gaacagaaat tcggccccca tctggtgccc atcctggtgg 900 agaaatgtgc agagttcatc ctggagcacg gccggaatga agagggcatc ttccgtctgc 960 ctgggcagga caacctggtg aagcagctga gagacgcttt tgatgctggg gagcggccct 1020 cctttgacag agacacagat gtgcacactg tggcttccct gttaaagctc tacctccgag 1080 acctcccaga gcccgtggtt ccctggagcc agtacgaagg gttcctgctc tgtgggcagc 1140 tcacgaatgc ggatgaggca aaggctcagc aggagttgat gaagcagctc tccatccttc 1200 ctcgtgacaa ctatagtctc ctgagctaca tctgcaggtt cctacatgaa atacagctga 1260 actgtgctgt taacaagatg agtgtggaca acctggctac tgtgattggt gtgaatctca 1320 tcaggtcgaa ggtcgaagac cctgccgtga tcatgagagg gactcctcag atccaaagag 1380 tgatgactat gatgatcaga gaccatgaag tcctcttccc caagtccaag gatatacccc 1440 tgtcaccccc tgcccagaaa aatgacccca agaaagctcc agtggcccga agctctgtag 1500 gctgggatgc cactgaagac ctccgaattt ctaggacaga cagcttcagt agcatgacaa 1560 gcgactctga tacaaccagc cccaccggac agcagccgag cgatgcgttt ccggaggaca 1620 gcagcaaagt acccagggaa aagccaggag actggaaaat gcaatctcgt aaaaggactc 1680 aaacactccc taaccggaaa tgtttcttga catcagcttt tcagggtgcc aacagcagca 1740 aaatggagat ctttaaaaat gaattctggt cgccttcctc agaggctaag gcaggggaag 1800 ggcacaggag aacgatgtct caagacttgc gccaactttc tgactcccaa cggacttcca 1860 cctacgataa cgtcccttcc ctgccagggt cccctgggga ggaagccagt gcactctctt 1920 cccaagcctg tgactccaag ggagatactc ttgccagtcc aaactctgaa actgggcctg 1980 gaaaaaagaa ctctggagaa gaggaaattg attctttgca gaggatggtc caagagctac 2040 gaaaggaaat agaaacacag aagcaaatgt atgaggaaca gattaaaaac cttgagaagg 2100 aaaattatga cgtttgggct aaagtggtga ggctcaatga agaactggag aaggaaaaga 2160 agaagtctgc agccctagag atcagcctcc gcaacatgga gcgctcccgg gaggatgttg 2220 agaagaggaa caaggccttg gaagaagaag tcaaggaatt tgtcaaatcc atgaaggaac 2280 ccaagaccga ggcttaaggg tcccaggagt actgcaggga cagccccaga gaggcccaac 2340 tctggcccct ttctcagtgc tatctgatga cggggaaaca aaattattct ctgagaggga 2400 aaggacattt gagggaaaca tcaaatttcc ccataaataa atgaatggag tttgcaggaa 2460 ggtgagggtg agcagagatg tgtgtggaca tctctgacca tccatcgctg tattcaaatg 2520 gattgtttta ttccattctg gtctcaggca tgaccacgtc cagtgaagac atttgaggca 2580 gcacatctca ggacccaggc aatagactgg ccccaactca ggctggacta aggtgtgatt 2640 aattctttgt tttttgtgtg gaacagctca ccttgtcaga cagcctcagg gcatctctga 2700 gacacagggg cagaaaatga cattcatctt ttgagtcctc atccatggag tgctgtgttt 2760 ggggggctgc atctgctgaa gcgagaaccc cattctgcca ccccaccagg atgcccattc 2820 tccaggactt ctccaactta ctattagact aaaccagaac aagcaacaaa ctgtatttat 2880 gcaagcaaaa ttgatgagaa aattatattc aaataaagca aaaattaaaa aaaaaaaaaa 2940 aaaaaaaaaa aaaaaaa 2957 <210> 80 <211> 1258 <212> DNA <213> Homo sapiens G protein-coupled receptor 174 (GPR174) <400> 80 caccattagg caaagatagt ttctctagag agaatcatgc ctgctaatta cacgtgtacc 60 aggccagatg gagacaatac agattttcga tactttattt atgcagtgac atacactgtc 120 attcttgtgc caggtctcat agggaatata ttagccctgt gggtattcta tggttatatg 180 aaagaaacaa aacgagctgt gatatttatg ataaacttag ccattgctga cttactacaa 240 gttctttcct tgccactgag gatcttctac tacttgaatc atgactggcc atttgggcct 300 ggtctctgca tgttctgttt ctacctgaag tatgtcaaca tgtatgcaag catctacttc 360 ttggtctgca tcagtgtgcg acgattttgg tttctcatgt acccctttcg cttccatgac 420 tgcaaacaga aatatgacct gtacatcagc attgctggct ggctgatcat ctgccttgcc 480 tgtgtactct ttccactcct cagaaccagt gatgatacct ctggcaatag gaccaaatgc 540 tttgtggatc ttcctaccag gaatgtcaac ctggcccagt ccgttgttat gatgaccatt 600 ggcgagttga ttgggtttgt aactccgctt ctgattgtcc tatattgtac ctggaagacg 660 gttttatcac tgcaagataa atatcccatg gcccaagatc ttggagagaa acagaaagcc 720 ttgaagatga ttctaacctg tgcaggggta ttcctaattt gctttgcacc ttatcatttc 780 agttttcctt tagatttcct ggtgaagtcc aatgaaatta aaagctgcct agccagaagg 840 gtgattctaa tatttcattc tgtggcattg tgtcttgcta gtctgaattc atgtcttgac 900 ccagtcatat actacttttc cactaatgag ttccgaagac ggctttcaag acaagatttg 960 catgacagca tccaactcca tgcaaaatcc tttgtgagta accatacagc ttccaccatg 1020 acacctgaat tatgctaaaa caaaaaacca aactgaatgt gacctgaaat gcaagtacat 1080 cagaacatat ctgcaatacc caagccacag ggaagaactt gcaaaacaac acagcttttc 1140 agttctgctc tatcttactg ctatggggaa ttcacttctt caaagcagga cctatttgga 1200 gcattacgat ccacgattat tgatgttgac atgtccatgt agtaattttt cttcaagt 1258 <210> 81 <211> 4876 <212> DNA <213> Homo sapiens FYN binding protein (FYB) <400> 81 ccgcagttct tgagttccac atgcagagca gatgcgacag ctagaagtga gtagggccca 60 gaccctggcc caggaagatc cactaaagga ggccatcctt ccgccttctt ctgcaggagt 120 caggatggaa aggcagatgt aaagtccctc atggcgaaat ataacacggg gggcaacccg 180 acagaggatg tctcagtcaa tagccgaccc ttcagagtca cagggccaaa ctcatcttca 240 ggaatacaag caagaaagaa cttattcaac aaccaaggaa atgccagccc tcctgcagga 300 cccagcaatg tacctaagtt tgggtcccca aagccacctg tggcagtcaa accttcttct 360 gaggaaaagc ctgacaagga acccaagccc ccgtttctaa agcccactgg agcaggccaa 420 agattcggaa caccagccag cttgaccacc agagaccccg aggcgaaagt gggatttctg 480 aaacctgtag gccccaagcc catcaacttg cccaaagaag attccaaacc tacatttccc 540 tggcctcctg gaaacaagcc atctcttcac agtgtaaacc aagaccatga cttaaagcca 600 ctaggcccga aatctgggcc tactcctcca acctcagaaa atgaacagaa gcaagcgttt 660 cccaaattga ctggggttaa agggaaattt atgtcagcat cacaagatct tgaacccaag 720 cccctcttcc ccaaacccgc ctttggccag aagccgcccc taagtaccga gaactcccat 780 gaagacgaaa gccccatgaa gaatgtgtct tcatcaaaag ggtccccagc tcccctggga 840 gtcaggtcca aaagcggccc tttaaaacca gcaagggaag actcagaaaa taaagaccat 900 gcaggggaga tttcaagttt gccctttcct ggagtggttt tgaaacctgc tgcgagcagg 960 ggaggcccag gtctctccaa aaatggtgaa gaaaaaaagg aagataggaa gatagatgct 1020 gctaagaaca ccttccagag caaaataaat caggaagagt tggcctcagg gactcctcct 1080 gccaggttcc ctaaggcccc ttctaagctg acagtggggg ggccatgggg ccaaagtcag 1140 gaaaaggaaa agggagacaa gaattcagcc accccgaaac agaagccatt gcctcccttg 1200 tttaccttgg gtccacctcc accaaaaccc aacagaccac caaatgttga cctgacgaaa 1260 ttccacaaaa cctcttctgg aaacagtact agcaaaggcc agacgtctta ctcaacaact 1320 tccctgccac cacctccacc atcccatccg gccagccaac caccattgcc agcatctcac 1380 ccatcacaac caccagtccc aagcctacct cccagaaaca ttaaacctcc gtttgaccta 1440 aaaagccctg tcaatgaaga caatcaagat ggtgtcacgc actctgatgg tgctggaaat 1500 ctagatgagg aacaagacag tgaaggagaa acatatgaag acatagaagc atccaaagaa 1560 agagagaaga aaagggaaaa ggaagaaaag aagaggttag agctggagaa aaaggaacag 1620 aaagagaaag aaaagaaaga acaagaaata aagaagaaat ttaaactaac aggccctatt 1680 caagtcatcc atcttgcaaa agcttgttgt gatgtcaaag gaggaaagaa tgaactgagc 1740 ttcaagcaag gagagcaaat tgaaatcatc cgcatcacag acaacccaga aggaaaatgg 1800 ttgggcagaa cagcaagggg ttcatatggc tatattaaaa caactgctgt agagattgac 1860 tatgattctt tgaaactgaa aaaagactct cttggtgccc cttcaagacc tattgaagat 1920 gaccaagaag tatatgatga tgttgcagag caggatgata ttagcagcca cagtcagagt 1980 ggaagtggag ggatattccc tccaccacca gatgatgaca tttatgatgg gattgaagag 2040 gaagatgctg atgatggctc cacactacag gttcaagaga agagtaatac gtggtcctgg 2100 gggattttga agatgttaaa gggaaaagat gacagaaaga aaagtatacg agagaaacct 2160 aaagtctctg actcagacaa taatgaaggt tcatctttcc ctgctcctcc taaacaattg 2220 gacatgggag atgaagttta cgatgatgtg gatacctctg atttccctgt ttcatcagca 2280 gagatgagtc aaggaactaa tgttggaaaa gctaagacag aagaaaagga ccttaagaag 2340 ctaaaaaagc aggaaaaaga agaaaaagac ttcaggaaaa aatttaaata tgatggtgaa 2400 attagagtcc tatattcaac taaagttaca acttccataa cttctaaaaa gtggggaacc 2460 agagatctac aggtaaaacc tggtgaatct ctagaagtta tacaaaccac agatgacaca 2520 aaagttctct gcagaaatga agaagggaaa tatggttatg tccttcggag ttacctagcg 2580 gacaatgatg gagagatcta tgatgatatt gctgatggct gcatctatga caatgactag 2640 cactcaactt tggtcattct gctgtgttca ttaggtgcca atgtgaagtc tggattttaa 2700 ttggcatgtt attgggtatc aagaaaatta atgcacaaaa ccacttatta tcatttgtta 2760 tgaaatccca attatcttta caaagtgttt aaagtttgaa catagaaaat aatctctctg 2820 cttaattgtt aactcagaag actacattag tgagatgtaa gaattattaa atattccatt 2880 tccgctttgg ctacaattat gaagaagttg aaggtacttc ttttagacca ccagtaaata 2940 atcctccttc aaaaaataaa aataaaagaa aaaggaaaat cattcaggaa gaaatgacct 3000 gtctaaaaaa acctaaggaa gaataataat ataagaaagg aaatttaaaa acattccaca 3060 agaagaaaaa ttattgttta tacttctact tatggttata tcttatattc tctattcaag 3120 tgacctgtct tttaaaaagg cagtgctgtc ttacctcttg ctagtgggtt aaatgttttc 3180 aaaaattata gcagtagtag aagttttgta taaaatttgt ccttatttgt taattgtata 3240 taaatgttaa ttatttgata cgaatgttat gcatttagta tgcacattga agtctaaact 3300 gtagaagagt ctaaaacaag ttctcttttt gcagattcac atactaatgg tttaattctg 3360 tgctctgttt aaagtactat tataactaga gtagatctga atgaggataa ccctaaaatc 3420 atgaggaatg gaagaatgga ccttgaaact acctaggctt ttatgcatgg cacctcttta 3480 taatgaagac actttttaaa gtttttgttt ttgtttcaat taccgctaga tttttttttc 3540 tcttttttta aaatccattt tactggaaag ttggccagca gagggagtag aaattattaa 3600 aattctagtg tttggattgg gcccttctct aacagtacat actcattccc aaagcaatcc 3660 aaaaacaaaa tgtgaaccat ttgggtttca aatgttaaga acactaaata gcatgattta 3720 aaaaatgaaa aatgctaaca cccaagaaaa gaagatatta agtgcttttt aacaactcct 3780 agagtacaaa atgagtacat cataatgctg gctcttctac taatgaacca tcgagtgata 3840 ttgaataaat tatttatctt ctcagtttcc ttatctgtaa attacaatat tagactaagt 3900 aagtttttcc aactcttcac taccaattac cttaggcttt tataatgctc cgcctacttc 3960 agtcccatgt ttcagaagct tttgtctatt ttttaaactc attgattaaa taatgattaa 4020 tgcattctcc acattttaat attgcaaagg cccattggag tttctgaagt ggctccacag 4080 aattgaaata atttcaaata actgtaaagg aactgaaaat cttcacagag atgaagtggg 4140 gtttccatta ggtgctttga aatttgataa caaatcatca acttccactg gtcaatatat 4200 agattttggg tgtctgaggc cccaagatta gatgccacta atctccaaag attccctcca 4260 attatgaaat attttaatgt ctacttttag agagcactag ccagtatatg accatgtgat 4320 taatttcttt tcacactaga taaaattacc tggttcaaaa gtggtttttg tttattaaat 4380 ttggtaataa atatatataa tacacagaca ggatagtttt tatgctgaag tttttggcca 4440 gctttagttt gaggactcct tgataagctt gctaaacttt cagagtgccc tgagacactt 4500 ccagccatcc ctcctcctgc cttcattggg gcagacttgc attgcagtct gacagtaatt 4560 ttttttctga ttgagaatta tgtaaattca atacaatgtc agtttttaaa agtcaaagtt 4620 agatcaagag aatatttcag agttttggtt tacacatcaa gaaacagaca cacataccta 4680 ggaaagattt acacaataga taatcatctt aatgtgaaag atatttgaag tattaatttt 4740 aatatattaa atatgatttc tgttatagtc ttctgtatgg aattttgtca cttaagatga 4800 gctgcaaata aataatacct tcaatggaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 4860 aaaaaaaaaa aaaaaa 4876 <210> 82 <211> 2282 <212> DNA <213> Homo sapiens cytohesin 1 interacting protein (CYTIP) <400> 82 gttgtacttt tagcttcccc catcctgcaa ggccactcaa ccatgtgcta gctggagtga 60 tctttattca caatgtcttt acaaaggctc ctgcaacaca gcagcaatgg caatttggcg 120 gacttctgcg ctgggccagc gtatagctct tactccacac tcaccggcag ccttacgatg 180 gacgataata gaaggattca aatgctagca gacacggtgg ctactctgcc tcggggacga 240 aagcagcttg ctttgaccag atcaagttct ttaagtgact tttcctggtc tcaaagaaag 300 cttgttactg tggagaagca ggataatgaa acatttggat ttgaaattca gtcttacagg 360 ccccagaatc agaatgcctg ctcctcggaa atgttcactt tgatatgcaa aatacaggag 420 gacagcccag ctcactgtgc tggcctgcaa gctggtgatg tccttgcaaa tatcaatggt 480 gtgagcacag aaggttttac ctacaaacaa gtcgttgacc tgatcagatc gtccggaaac 540 ctgctaacga tagagactct taatggaaca atgattctga aaagaacgga gcttgaagca 600 aagctgcagg ttttaaagca aactttgaaa caaaaatggg tggagtacag atctctgcag 660 ttacaggaac atcgtctgct tcatggtgat gcagctaatt gccccagttt ggaaaacatg 720 gacttggatg aattgtcttt gtttggaccc ctgcctgggc caggcccagc ccttgtggac 780 cggaatcgat tatccagtga gagcagctgt aagagctggc tgagctccat gacgatggac 840 agtgaagatg gctaccagac gtgtgtgtct gaggactcca gcaggggtgc cttcagtcgg 900 cagacgagta cagatgatga gtgctttatc cccaaggagg gggatgattt tctgaggagg 960 tcatcttcaa ggaggaaccg gagcatcagt aacaccagca gcggatccat gtctcccttg 1020 tgggagggca acttatcaag catgtttggg accctgcccc ggaagagcag aaagggaagt 1080 gtccgaaagc aactcttgaa atttatccct ggccttcatc gtgctgtgga agaggaagaa 1140 agtcgctttt gacggattgt ggtgtccttt caaattagct tatttcacaa atatctctag 1200 actcacccag atcccagctt ggtgggaaag tgcagaagaa ttgcaaaact gacatcccat 1260 ttcacagcaa tagtgacctt tatttaaatt gttgtgttat agtttatgct tcttaaatca 1320 tttttcaacc taaacagcca atttctaagc agacaggaaa actaaataat aagttaatta 1380 atataacaaa gatgcaggtt cctgctcatt ccagtaatgt ctttgaaagc aaaactaata 1440 tttattttct agattatccc tgtgaataat tgagaacttt ttggagtcaa gtatgaataa 1500 aggtgtggca gaatataata atctggacta ttttctatag gataattgct gggttataaa 1560 atcttaggtt tgcttatgcc cagtagctcc tgcggaggct taataatagg caattttgaa 1620 tttgttcaaa cctgtaatgg cttgtaaaca aagatgacca tcagctgttt ctcacatcta 1680 tagtgacaat aaagcgggaa gtataagatt taataggagg ggttaaggtt catgagaacc 1740 atggaaagat gtggtctgag atgggtgctg caaagatcat aataaagtca tttttataga 1800 cagtctaaac aaaatgggtg gggatgtcgt gttttttgcc caattcagct tttgttctgc 1860 ctgaacatta atggcaagtc tagaactctc cgaatcctac agctttgtaa ttttttttct 1920 acaaatgtct aacatccaaa actgagggtt gggaaaagga cttccctcct gtagtttttt 1980 tcatattact tctcacttta tatcttatat tctaaatagc tatcacctca gcagtctttt 2040 gcctattggt tatgttagta tcacattact tctagccttt caattactcc atgttttatt 2100 taatatccat tgaagtctat gaattctctg ttctggtggc acagctattc ataacctata 2160 ttctagagta gacaatctgg actatgtaat aaatagtctg ctgattttaa aaaaaaaaaa 2220 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 2280 aa 2282 <210> 83 <211> 5420 <212> DNA <213> Homo sapiens chemokine-like receptor 1 (CMKLR1) <400> 83 agtcccattc agggaagcag ccccggcggc cagcagggag ctcaggacag agcaggctcc 60 ctgggaagcc tccgggtgat aggggtgttc cagctgcggc gctctggggg ttcagagggg 120 gatcttgaat gaacaaatga atgaactgct ttctgggcaa acagccacag ccagaggagc 180 ctgtgattgg cagaaagaag ccagggtgtg caagtctccc caacagcctc gagtggcctg 240 cagtcacagg gaaccctcag gaagaccttc cgggcagaga ccagagggaa gcccatctct 300 ccagcagaac tgcttggatt tttctaccag gaggctcagg gctctgcaac aatgatagca 360 gaagctgatg gcatctagag atctaggctg ggactagcac agcatcactt ctaccacttt 420 ctgttggtca cagcaactca ccatgccagt gcagattcaa ggggaggaga aatagagtcc 480 acttcttgat gggaggcgtg acatagaatg gaggatgaag attacaacac ttccatcagt 540 tacggtgatg aataccctga ttatttagac tccattgtgg ttttggagga cttatccccc 600 ttggaagcca gggtgaccag gatcttcctg gtggtggtct acagcatcgt ctgcttcctc 660 gggattctgg gcaatggtct ggtgatcatc attgccacct tcaagatgaa gaagacagtg 720 aacatggtct ggttcctcaa cctggcagtg gcagatttcc tgttcaacgt cttcctccca 780 atccatatca cctatgccgc catggactac cactgggttt tcgggacagc catgtgcaag 840 atcagcaact tccttctcat ccacaacatg ttcaccagcg tcttcctgct gaccatcatc 900 agctctgacc gctgcatctc tgtgctcctc cctgtctggt cccagaacca ccgcagcgtt 960 cgcctggctt acatggcctg catggtcatc tgggtcctgg ctttcttctt gagttcccca 1020 tctctcgtct tccgggacac agccaacctg catgggaaaa tatcctgctt caacaacttc 1080 agcctgtcca cacctgggtc ttcctcgtgg cccactcact cccaaatgga ccctgtgggg 1140 tatagccggc acatggtggt gactgtcacc cgcttcctct gtggcttcct ggtcccagtc 1200 ctcatcatca cagcttgcta cctcaccatc gtgtgcaaac tgcagcgcaa ccgcctggcc 1260 aagaccaaga agcccttcaa gattattgtg accatcatca ttaccttctt cctctgctgg 1320 tgcccctacc acacactcaa cctcctagag ctccaccaca ctgccatgcc tggctctgtc 1380 ttcagcctgg gtttgcccct ggccactgcc cttgccattg ccaacagctg catgaacccc 1440 attctgtatg ttttcatggg tcaggacttc aagaagttca aggtggccct cttctctcgc 1500 ctggtcaatg ctctaagtga agatacaggc cactcttcct accccagcca tagaagcttt 1560 accaagatgt catcaatgaa tgagaggact tctatgaatg agagggagac cggcatgctt 1620 tgatcctcac tgtggaaccc ctcaatggac tctctcaacc cagggacacc caaggatatg 1680 tcttctgaag atcaaggcaa gaacctcttt agcatccacc aattttcact gcattttgca 1740 tgggatgaac agtgttttat gctgggaatc tagggcctgg aacccctttc ttctagtgga 1800 cagaacatgc tgtgttccat acagccttgg actagcaatt tatgcttctt gggaggccag 1860 ccttgactga ctcaaagcaa aaaaggaaga attctcaaaa gcattgccat gaactgggat 1920 tggcataggg cggtgggatt aagctgccta ttgtgtgtgc cccagaaatg acactctcca 1980 aggtccattc ctggtgtgag cagtgagggg gtcagagcaa acccagtgtg atgcagatca 2040 cacttggccc ttgtatatat attatcagta gctggccaga aaaccctacc ttcaagtcac 2100 tgctctgtgt taaagtatgt ggaaatgcat aggtgatctg ggagaggaag gtgacatatc 2160 agcccatgaa ctccataggc catgaatttg gctttcggat cagctaggaa gacagagaac 2220 tggtcctgag aggtcctgtg ggctctttgc aagggcaaga caagtgaggg atgcaacgag 2280 gacttgagat ttggcaaaga aatgagaaag gagaaaagaa cctttaaagg atgcaggcat 2340 ggagcagctc accctagaac atcgcaggct gatggtgctt taggctggag ctatttgggg 2400 cgtcagggtg gtgccagccc ctgatctcac cttgcccctc ttacctgggg gtggggttgt 2460 ggcaggcatc ttcaccagca gccctcaccc catcacaggg atttttttct gcctttccta 2520 atccactcag ctctggctgg aggtgcttag aataaaacac tggtggtggg gcttctcatt 2580 ctggttaatt tcctcaacgc ctttggagac aggtccaaaa tgcagctttg ggaagcaact 2640 ccggagagtc ccctgggaag aagagtatgt ccgaggactc agtcacttga gacagagtct 2700 ggagctggac tccttgaact gtgtttctga gctgcagaca ccaaatacct cctggataca 2760 ggtgcctggc atggcttttc tcatctaata ctgacacgtc cctgtggcca cagagtgtca 2820 tagccccatt tacaaatgac atagctgagg cccagatggg gaaagtaact tgcccagcat 2880 cacacagcta atcagtggca gagttaagat ctgaacctgg ctccgtctgg ctccagaaac 2940 tctgttcttc tatttggaat ttatctgtgg agattattct agtatattga tagcctacat 3000 ttatttagca ctttttatat tatgcacttt acatatgttt tctcatttaa tcattacagc 3060 aaccctgagt taggtatggt tataacttcc cttttacata ggaggaatct gaggcttaga 3120 gaggttaagt aacttgccca aaggtaccca gctagtctct gccggagctt ggatttgaac 3180 ttcagtttgc ctggctcaaa tgaggctgca gagttgggaa ggacttaaaa agtttggaga 3240 tttttgccat aaatattgat ttttctgcaa atgaggatga acatcttaat ggcctttaag 3300 aaactttgca aatagttttc aaaaatgatg caacatggca gagaaaatgc acttggcttc 3360 cagctccctc aacagccatt aacagcctcc taccgtggct cccacctcct atgtctccag 3420 agatcaaggc aatggggagg gaaagctggc aggaggcagt cccttgtggg cctgaggccc 3480 tttggctcct aagtgtccac attctgttct cttccaagtc ccttcattgt taagctgatt 3540 ctccaacaag atgcaatgaa cagatgcaat gtctaccccg cgctgggcga gttcccgagg 3600 ccatgggctg tttggaatca cacttcatta agagacaaac tgttccttcc cttattgtgc 3660 cttaatgctt atgacaaggc agctctgaat tgatcccaag ctggagcctc tgaatgcttt 3720 aaagagtttg aatatagacg gtttgagagc aaaaagggag ctttaaatat tgctcagtgg 3780 cccccatctc ccctcttccc acatttactg aggcacgaga tgggatggga cctgtcccgg 3840 gtcacagcag cagtcgtcag cgccttggcc ctcctggctt gtaggatgct gcttttcctg 3900 ggcttctggc agtccaggcc aggatggggg agccaggaat tcatgttgtc attggaaaag 3960 ctgataaaca ggagcacaat tcaaaccggc tgttttcctc cttagagtct ggcctccctc 4020 tttctggctg ctctgtgggt cttcctgttc tgacttaggt tcctgtcaag tacttaaatg 4080 cagccttaac atcccataca gtcttgtccc cacagcttca tgtgaacatc tccatgggtc 4140 atgcatatat cgtccctgca gtgtgcaaag tgtgctcacc tgcactgctg cacaggcaac 4200 caacatactt agtgcccaga gccttctctc tgggcccagg actcagtgat ggggccttac 4260 ttagccctgc ctcctgggtg gggtggggga gctgagggat cgtgaggaca agaggtagag 4320 ggaaaagaaa agaagatggt gtttgaggat aggggaggga caggagaggg gacagaaagg 4380 tcccagagca tgatgatgaa ggaaagggat ctggcattca tgaagcacct acgatggttc 4440 aggcacaaac actgaaacct caaattggcc ctggcagaag gggaccatca tagcaaggtg 4500 gggggggggt gcagaaagtg agtttctgtt tcaagaacag acttcactag ttcagagttg 4560 cacagctagt gaggtatgga gctgggcttt gaatcaggtc agctgcctga atgcccaact 4620 tcttcagccc ttggaaggag agggtgggga gaagaagaag gaaaagacaa ggaagaaaga 4680 aagaagagag aaggggagag gaatggaagt ccaaagagtg ggaggaattt gatttcagaa 4740 ccatctccag ctgacccttg agccagcaag gacagggaga agggaagagc aagaacacga 4800 agggcctcaa gcaccgggat gcctttgcca gccttagata attcccagag cgcacagagc 4860 cctgcaggtt cctgggtcct tctccagaga agaggcacag agattctggc agcaaggttc 4920 agaaggggtg aggaaactgg gcactgacaa agggagggga ttggctcaaa ttcgacccca 4980 gagtcagctc tggtggggtt gggagcctgg atgggtggga gaagatagaa tccaatcgtg 5040 aaaaccataa gggaccttca aactcatctt gcccagatgt ctcccatttc acagatgagg 5100 gaactgaggt tttgagagct tcccctgagg actctgcaaa acgaggtggt gtctggtttg 5160 gatgaaagtg gtcggtgatt cctcaactcc tgccctgcct ccctctctcg ttcctcccta 5220 acatgttatg ctcttgttgg ggctgggatg ccctaggccc aaggttacca aatcctgggt 5280 ttggaaaatt gctgctgggg gtggtatcta ggaccagaga ggaatctact atttctactg 5340 tgaaataatt cagcaggggg tcttcttact tcttcccttt gaggacaaag tttctctcga 5400 ataaagagac tgaagcaaga 5420 <210> 84 <211> 3909 <212> DNA <213> Homo sapiens NCK-associated protein 1-like (NCKAP1L) <400> 84 agagggtgtc accatctaag ctgaaagtgt ttggggagat cagacattgc tgtctggtgc 60 tcctctctca gtggccatca tgtctttgac atctgcttac cagcataaat tagcagagaa 120 gctcactatc ctgaatgatc gcggtcaggg ggttctcatc cgtatgtata acatcaagaa 180 gacttgttca gaccccaaat ctaagccacc tttcttactg gaaaagtcca tggaaccatc 240 tctcaagtat atcaacaaga aatttcccaa catagatgtc cgaaacagca cgcaacattt 300 aggaccagta catcgtgaaa aagccgagat aattagattc ctcaccaact actaccagtc 360 atttgtggat gtcatggaat ttcgggatca tgtatatgaa cttctcaaca ccattgatgc 420 ctgccagtgc cattttgata tcaatctcaa ctttgatttc actcggagtt acctggactt 480 gattgtaact tacacctcag tcattttact tctgtcacgg attgaagatc ggcggatact 540 cattggcatg tacaattgtg cccatgagat gctgcatggg catggtgacc ccagttttgc 600 ccgtctgggt cagatggtct tggagtatga ccaccctctg aagaagctga cagaagagtt 660 tgggcctcac acaaaggctg tgagtggagc cctcctctct ttgcatttcc tctttgtccg 720 aagaaaccag ggggctgagc agtggcgcag tgcccaactt ctaagcctca tcagcaaccc 780 cccagccatg attaaccctg ctaattcaga tacaatggcc tgtgagtatc tgtctgtgga 840 agtaatggag cgctggatta tcattgggtt tcttctttgt catgggtgcc tcaactccaa 900 tagccagtgc cagaagctgt ggaagctgtg tctgcagggc tccctctaca tcacccttat 960 ccgtgaggat gtgctgcagg tgcacaaagt caccgaggac ctgtttagca gtttgaaagg 1020 gtatggcaag agagtggcag acataaagga gagcaaggaa catgtaattg caaacagtgg 1080 ccagtttcat tgtcaacggc ggcaatttct gcggatggca gtgaaggagc tggagactgt 1140 gttggctgat gaaccgggac tactgggtcc taaggctctt tttgctttca tggccctgtc 1200 cttcattcgt gatgaggtca cctggctggt tcgccacaca gagaatgtca ccaagacaaa 1260 gacacctgag gactatgctg actcgagcat tgcagagcta cttttcttgt tggaggggat 1320 taggtctctg gtccgaagac acatcaaagt gatacagcaa taccaccttc agtacttggc 1380 aagatttgat gctcttgtgc tcagtgacat cattcagaac ttgtctgtgt gtccagagga 1440 ggagtccatc atcatgtcct cattcgtcag tatcctctcc tctctgaatc tcaaacaagt 1500 tgataatgga gaaaaatttg aattctcagg attgaggctg gactggttcc gcctacaggc 1560 atacactagc gtggctaagg cccctctgca cctgcatgag aaccctgact tagccaaggt 1620 gatgaacctc attgtcttcc actcccgaat gctggactcc gtagaaaaat tgctggtgga 1680 aacttctgat ctgtctactt tctgctttca tcttcgtatc tttgagaaga tgtttgccat 1740 gaccttggag gaatctgcca tgttgcgtta tgccattgct ttccccctga tttgtgctca 1800 ctttgtccac tgcactcatg agatgtgccc agaggagtac ccccacctca agaaccatgg 1860 tcttcaccac tgcaactcct tcctggaaga gttggccaag cagaccagca attgcgtcct 1920 ggagatctgt gctgagcagc gaaacctgag cgagcagctt ctacctaagc actgtgccac 1980 tacaatcagc aaagccaaga acaagaaaac caggaagcag aggcagactc ccagaaaagg 2040 agagcccgag agggacaagc caggagctga gagtcaccgg aagaaccgca gcattgtcac 2100 caacatggac aagctacacc taaacttgac agaactggca ctgacaatga atcatgtata 2160 cagtttctcc gtgtttgaac atactatctt cccttctgag tacctcagca gccacctgga 2220 ggccagactc aacagagcca ttgtgtggct ggctggctac aatgccacga cccaggagat 2280 cgtacggcct tctgagctgt tggcaggagt caaagcatac attggtttca tacagtcact 2340 ggcccagttt ttgggtgcag atgcttccag agtcatccgc aacgccctcc tgcagcagac 2400 acaaccactg gattcctgtg gggaacagac aatcaccaca ctctacacaa actggtacct 2460 ggaaagtctg cttagacagg caagcagtgg gaccatcatc ctctccccag ccatgcaggc 2520 cttcgtcagc ctgcccagag aaggggagca gaacttcagt gcagaggagt tctctgacat 2580 ctctgagatg cgggccttgg cagaactcct gggcccctat ggcatgaagt tcctgagtga 2640 aaacctgatg tggcatgtga cctctcagat tgtggagctg aagaagctgg tggtggaaaa 2700 catggacata cttgttcaga tcagatccaa ctttagcaag ccggacttga tggcttccct 2760 gctgccccag ctgacagggg ctgaaaatgt gctaaagcgc atgaccatca ttggggttat 2820 cctcagtttc agggccatgg cccaagaggg acttcgggag gttttctcct cccactgccc 2880 atttcttatg ggtcccattg agtgcttgaa ggagtttgtc actccagaca cagacatcaa 2940 ggtgaccttg agtatctttg agctggcatc tgctgcaggt gtgggctgtg acattgaccc 3000 agccttggtg gctgccattg ctaatctgaa agctgatact tcatctcctg aggaggaata 3060 taaggtggcc tgcctgctct tgatctttct ggcagtttcc ctcccactcc ttgccactga 3120 cccttcttcc ttttatagca ttgagaagga tggttacaac aacaatattc attgcttgac 3180 caaagccatc atccaggtgt ctgctgccct cttcacgctc tacaacaaga acattgaaac 3240 tcacctcaag gaatttctgg tggtggcctc tgtcagcctc ttgcagctgg gccaggagac 3300 tgacaagctt aaaaccagaa atcgagaatc catttctctg ctcatgcgct tggtggtgga 3360 ggagtcatcc ttcctgaccc tggacatgct ggagtcctgt ttcccttatg tcctgcttcg 3420 aaatgcctat cgggaggtgt ctcgggcctt ccacctaaac tgaatgcctg ccagtaccca 3480 ctgaagagcc ctttggacct tcctaaaccc ttgccatagt ggaagctgtg gtcactttcg 3540 cagggggtgg gaatggggtg gggtcactaa ggagagaggg tcaggagcca gagttgatga 3600 gcagatctgt ggaagaacaa tccagggctg agaaatcgta gagcagtgag gcaggctggg 3660 agcatggagg acagcttatg gaaaaagtta gggcgtgggg ccacatgtgt gaattttaca 3720 atgaaaaaag gagtaacgta caagtatatt ttctatcttc tggtgacttg agcttgagct 3780 ctgacaggca tgggcctctc cgaccttcat cactattctt aggataatgc tggcgggcag 3840 agatgatcaa tcatcatatt aaatcataat gagcttataa tcctcccact ggaaaaaaaa 3900 aaaaaaaaa 3909 <210> 85 <211> 8245 <212> DNA <213> Homo sapiens CD84 molecule (CD84) <400> 85 ggaggaagaa aactcaagtg aaactgactc tgctagaaca gtgccgtgct tttccacaga 60 aggttagacc ctgaaagaga tggctcagca ccacctatgg atcttgctcc tttgcctgca 120 aacctggccg gaagcagctg gaaaagactc agaaatcttc acagtgaatg ggattctggg 180 agagtcagtc actttccctg taaatatcca agaaccacgg caagttaaaa tcattgcttg 240 gacttctaaa acatctgttg cttatgtaac accaggagac tcagaaacag cacccgtagt 300 tactgtgacc cacagaaatt attatgaacg gatacatgcc ttaggtccga actacaatct 360 ggtcattagc gatctgagga tggaagacgc aggagactac aaagcagaca taaatacaca 420 ggctgatccc tacaccacca ccaagcgcta caacctgcaa atctatcgtc ggcttgggaa 480 accaaaaatt acacagagtt taatggcatc tgtgaacagc acctgtaatg tcacactgac 540 atgctctgta gagaaagaag aaaagaatgt gacatacaat tggagtcccc tgggagaaga 600 gggtaatgtc cttcaaatct tccagactcc tgaggaccaa gagctgactt acacgtgtac 660 agcccagaac cctgtcagca acaattctga ctccatctct gcccggcagc tctgtgcaga 720 catcgcaatg ggcttccgta ctcaccacac cgggttgctg agcgtgctgg ctatgttctt 780 tctgcttgtt ctcattctgt cttcagtgtt tttgttccgt ttgttcaaga gaagacaaga 840 tgctgcctca aagaaaacca tatacacata tatcatggct tcaaggaaca cccagccagc 900 agagtccaga atctatgatg aaatcctgca gtccaaggtg cttccctcca aggaagagcc 960 agtgaacaca gtttattccg aagtgcagtt tgctgataag atggggaaag ccagcacaca 1020 ggacagtaaa cctcctggga cttcaagcta tgaaattgtg atctaggctg ctgggctgaa 1080 ttctccctct ggaaactgag ttacaaccac caatactggc aggttccctg gatccagatc 1140 ttctctgccc aactcttact gggagattgc aaactgccac atctcagcct gtaagcaaag 1200 caggaaacct tctgctgggc atagcttgtg cctaaatgga caaatggatg catacccttc 1260 ctgaaatgac tcccttctga atgaatgaca aagcaggtta cctagtatag ttttcccaaa 1320 cttcttccca tcatagcaca tgtagaaaat aatattttta tggcacactg ggataaacaa 1380 gcaagattgc tcacttctgg aagctgcata tgactagagg cctcttgtga ctggaggtaa 1440 caaccctgcc cagtaactgt gggagaaggg gatcaatatt ttgcacacct gtaataggcc 1500 atggcacacc agccaagatg ctctgctcac agtcagtatg tgtgaagatc cctggtgcgt 1560 ggccttcacc acgcatcttg agcaaattag gaaaatgtac ccttcgcttg aggcagatgc 1620 agcccttccc ccgagtgcat ggcttggaga gcagaatgtg ggctgcatat aagcacactc 1680 atccctttgt ctgggaatct ttgtgcaggg cataacaggc ttagtaagtc caaacacaga 1740 tgacagtgct gtgtgggtct ctgtcagagt tgtggctctc agccatgtag acacactctc 1800 caaatggagt gttggaaaat gttctttctg cagggtctag agactgctgg gacacttttc 1860 ttggagtgct acttcagaag ccttatagga ttttctttct ggccaagatt tccttctgta 1920 tcactccaag cagcctcagc agaagaagca gccatgccca gtattcccac tctccaaaag 1980 gaactgacca gcttatattt ctcacacttc tggggaactg ggtataatcc aaccatcaaa 2040 atagaagacc ttgcaagaag cagagtcatt ctccagaagg aacttgggag atgatggtgc 2100 agatgatgaa actgggttca tcccagttcc aaagactcag agaactagag tttaagctga 2160 ggcagagtgc cgccaccctg gcatgcccca caaacagatc accagccagc ttacacaggc 2220 attaactctc ctcaatgagg aagaatcatt cacaactgag caagacattc atatgatcat 2280 ttaaggaagt gtttccctta tgtgttagca agtataatcg gctaactcct aaatcccaat 2340 gaatagtcct aggctggaca gcaatgggct gcaattaggc agataaagac atcagtccca 2400 gtaaatgaat ccatagactc atctagcacc aactaccatt agcactatgt taggagctgc 2460 aaggccccaa agtagaagat gtgcataatg tctgctcttg tgtagctcag gagacaattc 2520 cagcacagac actacagtta acgctgaact gcagctgcaa gtaatagcat gaacagtcag 2580 aaaaatacct tatgaggggg cagggctgaa gctgggcctt gaaggatgga tgaaatttgg 2640 atagagaatg aggaagacag agggcctcca agtgagagaa gcatgaaaaa tgagcagggg 2700 cctggatcag tggggtgtat tcagagcacc tctccagatg caccatgcat gctcacagtc 2760 ccttgcctat gtgtggcaga gtgtcccagc cagatgtgtg ccctcacccc atgtccattt 2820 acatgtcctt caatgcccac ctcaaaaggt acctcttctg taaagctttc cctggtatca 2880 ggaatcaaaa ttaatcaggg atcttttcac actgctgttt tttcctcttt ggtccttcta 2940 tcactaaaac tcatctcatt cagccttaca gcataactaa ttatttgttt tcctcactac 3000 attgtacatg tgggaattac agataaacgg aagccggctg gggtggtggc tcacgcctgt 3060 aatcccaaca ctttgggagg ccaaggcagg cggatcacct gaggtcagga gttcgagatt 3120 agtctggcca acatggtgaa accccatctc tactaaaaat acgaaattag ccaggtgtgg 3180 tggcacacat ctgtagtccc agctactctg gaggctgaga caggagaatc gcttgaaccc 3240 aggaagtgga ggttgcagtg agctgagatc acaccactgc actccagcct gggagagaca 3300 gagtgagact ccatctcgaa aaaaaaaaaa agatagaagc caataagcat ggtgcaatca 3360 aattctggca agcattaaat atcaggatgc agctgggcac ggtggctcac gcctgtaatc 3420 ccagcacttt gggaggccaa ggtgggcgga tcacttgagg tcaggaattt gagaggatcc 3480 tggccagcat ggcaaaaccc catctgtact taaaatacaa aaaaattagc tgggcgtggt 3540 ggtgcacacc tgtaatccca gctacttggg aggctgaggt gggagaattg cttgaacctg 3600 ggaggtggag gttgcagtga gctgagatcc tgccactgca ctccaggctg ggcaacagag 3660 tgagaccatg tctcaaaaaa taaaaataaa ataaaataat atcaggatgc atacatcaga 3720 ggctgttcct agtgtaaagg cactttggag ggagaagact ttcagagtta ggcagaccaa 3780 ctaagaggtc agctgaagca cctaaccagt tgtaaggagg tgaaagacag caccccaaga 3840 agagacgtgc aggaaggagg aaagaggctt ggtcataaag gatggaggaa ttccaaagtg 3900 acactgaaca ggctgcgttt atcctaaaat aaaaccactc ctcactctgt ggatgcgttg 3960 aagactcatt cccaaacatc tttattctct aacttgccct cttcctcttc ctaatatgct 4020 cactcaagta aaattactag tgtcctaatg cccctatgca tattgtcaaa aataaaaatc 4080 agaagcaggt tagatctgtt aggtcttcca gaagagcaaa cctgggatga agccagagcc 4140 caggaattct gaaggtagcc tttggactca ggacacccta ctcttgtctc tcctctcagt 4200 ttctctgcta tgaatctcct gattcatgaa cacgttatct gttcaccctt ctctctaggt 4260 cttagttctt agattttcct tctgtaaaat gcatgtgatc ttattttccc ctccacaact 4320 ttccagatga actagactgt gaccaagagg tctataaaat caaagcatca tggaacagga 4380 tcttgtatca gaccaaagtg tgccagtttt taaaaatgtg catcaaaatg gaagtctcag 4440 agacagagcc ctctggtgga aagttctagt aggttaggac agtcctgcct gcagacacct 4500 tgggctttac tgagggactc aactgagaaa atgaggaatg ttgcagctca tgattcttag 4560 aagaagaaag tgaagcttgt ttaaaatatg atttaaaaaa tctgtagaac actgtaaact 4620 acacaggcta tgagggaata gcctggttgg gccagcttgg aaatcgggca caggcaggaa 4680 ggggcctgtc tggtttgggc cgtgtccaca gagagcactt cttaggtcct gcctggagag 4740 aaggaatggc tgggctatat tttcttccag actcattatt tttcttctgt ttgacttttc 4800 tctgaatttc ccttgatttg tataaatttt ctcaataatt agtgacagtg tctactgatt 4860 gtaaaatgaa gcttgaaggc caggcgcagt ggctcatgcc tgtaatccta gaattttggg 4920 aggccaaggt gggtggatca caaggagttc gagaccagcc tggccaaggt tgtgaaaccg 4980 cgtctctact aaaaatacaa aaaaattagc cgggcatggt ggcacgtgcc tgtagtccca 5040 gctactcagg aagctgaggc aacagaatca cttgaacctg ggaggtggag gttgcagtga 5100 gccgagatca cgccactgca ctccagcctg ggcgagagag tgagactccg tctcaaaaaa 5160 aaaaaaaaaa aaaaaagttt gaagaacaaa gacaataaga ggaaatataa tgagtggtca 5220 taaatgtggg ctctgacagt agagtgcctg ggtctgcatc ctggtttctt agtcatgtga 5280 ccttaggcaa gttactttaa cctcgctgta cctcaggttg tccatctgta aaatggggat 5340 aataatagtg cctacctttt aaggttgatg tggggattaa atgaggtgtt gctcatacag 5400 gaatgtgcct gtgcatggca aagttcggga aattttttat aagctgttct aggcctgaaa 5460 tcttcagaag atgctaatct aaattcatga aataagcttc ttacaacaga aatgctgcta 5520 gtattatgca aaattaatgt tgtatatcaa acttttaact ctcatccctc cttattcaga 5580 tatattttgt tataagcaat gtttgttccc ctcgttatta taccacagtc tacttacctg 5640 atgctatatc tgcctcccca gttagactga gagaacaggg gatataccta aataataata 5700 ataataataa taataataaa taataatgga gagctccttg aagataggga gcctgtaaga 5760 atcattgagg gcttattttg tataccaact gctaaactag atgcttcata cattgttgtc 5820 aatactcatg acagccttgt aaagtagaaa ttaattcttc cagttaacac taaggctgac 5880 atatgaatac cttggcaaat ctggaaagct gggaagacag tatttgaatt caagacttct 5940 tgtcaccaag ggccatgcac ttgtactctg ccatgtggcc cttttttacc tcctgtggat 6000 tctccctacc tggtacttgg ccttaggtgt acacacacct ggcactttgc ttgacacata 6060 ataggtggac cacaaatatc tactaaatga atatttgcat atagtaatat tttaaggtac 6120 taaaagcagc tcaaagtaaa tatattaata tattaattcc attgctatct ggataaccac 6180 tcaactttcc tgctgaaaat gcccatttaa ttaaagaagg ttggatagag ctctctatat 6240 gcattttgga caggcagggg tttcaggtca taaacattct gatgagttaa tataaaataa 6300 gagaaactgt aaatttccac tactaaaaat cacaaaaata acagaaacaa aagaagagat 6360 aagaatttgg ggaattgtgc tgaacaattt agtggttaaa aaaaacaact gtgcatgttt 6420 agacttaaat aagcccccat ccaagtgtga ggggtccagt aatttttcaa aacatatgaa 6480 agtgttaata catttcgaca aaggaccatt aaaaaagtcc tgaattctga cttgagggag 6540 gaaagtaatg actaatacat tctctagaga cttgcagact ttgggaattc ataaaggaat 6600 ggatgataat tattaactgt tgctggctga ttgcccagac agttctcaac agccctgtac 6660 aagtctctgg gtttgggatg gatcaattct gagactggaa aatggccaaa tctttgcaaa 6720 tgagaaatat ttttcttata agttcttatt gtaggcaaat aattacatag attattcatc 6780 agagaatttt taaatgctca taatctcaac tctttcattt acaacttgta tttccaatag 6840 tttatgggtc atctctgcat agatgtcaga agtcacctca agtttagcgt gtccaaaatc 6900 taactcacag gtctgtttct gacctcccaa cttgctttcc ttgtgttttt cctatgctaa 6960 tgatccacca taatcaaaat aattaacatt tatccagtgc ctactatgta ctattccctg 7020 tcctgtttta catttactca tttaaagtcc ataagaaaca ttaaatctca tctgccttct 7080 gaagaagata caaccatgct ctcttttaca aagtaggaaa ctgggtcaca gaaaggtgaa 7140 gtctttaagg ctgaatcaca gtagctcatc ctagtaaata gaaaagccag gattcaactc 7200 caggggctgg gtgcagaact gctattcttc actgcttcac caatcagcag ctacccaagg 7260 cagaaaactt tttcatcctt ggctccttca ttctccctgt caccccagat cccctctaca 7320 tctagtcaga gaataggtcc tgtcaattcc aacttctcta tatggctcct ctcaggcatg 7380 tgcccttaat tggcctaatt ctctaataca ccttccctct acatgctcac tccctcagat 7440 cattgcttta tcacgtgtta cctgggttgc tattacataa agagcaatct ttctaaaatg 7500 aggatcttat cacttcactt ccacactaaa atgtttttcc tggggaacca cactccttag 7560 caatctgacc catcagacct tccaggctgt ctcctgcctg ctccctaagg ctccagccac 7620 acagaattat catgggccca cacacccacc aaatcctccc atgcctttgc ccatgttgtc 7680 tgggatgccc ttctctccct tctgtctaca tcaagcatca gactgaatat ccctcttgtg 7740 cggccttcta aaacctcccg tccaaagcga aatatattgc cctctattta tacttttaca 7800 gcatttggca cacaagtaca gagtagtagc tttttatcac attctctgat aattatatag 7860 atatggtatt tcttagctct ctctccaact ggctaataag ttgctttttg tctgagtgcc 7920 taattttgtg ttttgtgtct gagtgcctca gttcctcaaa aaaaggtttt ttgattagtt 7980 cattattcat ttgaacatgg aaattatgct cactagtggc aaatgccact aaccgtattc 8040 cagaagctag gtgtcatgtt tgcaataaga tatattatcc cttctacaag tcacctttta 8100 tttcaggcat ttgtaaatgc ccattaataa agtatggttc ataaatttta ccttgtaagt 8160 gcctaagaaa tgagactaca agctccattt cagcaggaca caataaatat tattttataa 8220 tgcatctaaa aaaaaaaaaa aaaaa 8245 <210> 86 <211> 1809 <212> DNA <213> Homo sapiens interleukin 7 receptor (IL7R) <400> 86 gtcttcctcc ctccctccct tcctcttact ctcattcatt tcatacacac tggctcacac 60 atctactctc tctctctatc tctctcagaa tgacaattct aggtacaact tttggcatgg 120 ttttttcttt acttcaagtc gtttctggag aaagtggcta tgctcaaaat ggagacttgg 180 aagatgcaga actggatgac tactcattct catgctatag ccagttggaa gtgaatggat 240 cgcagcactc actgacctgt gcttttgagg acccagatgt caacatcacc aatctggaat 300 ttgaaatatg tggggccctc gtggaggtaa agtgcctgaa tttcaggaaa ctacaagaga 360 tatatttcat cgagacaaag aaattcttac tgattggaaa gagcaatata tgtgtgaagg 420 ttggagaaaa gagtctaacc tgcaaaaaaa tagacctaac cactatagtt aaacctgagg 480 ctccttttga cctgagtgtc gtctatcggg aaggagccaa tgactttgtg gtgacattta 540 atacatcaca cttgcaaaag aagtatgtaa aagttttaat gcacgatgta gcttaccgcc 600 aggaaaagga tgaaaacaaa tggacgcatg tgaatttatc cagcacaaag ctgacactcc 660 tgcagagaaa gctccaaccg gcagcaatgt atgagattaa agttcgatcc atccctgatc 720 actattttaa aggcttctgg agtgaatgga gtccaagtta ttacttcaga actccagaga 780 tcaataatag ctcaggggag atggatccta tcttactaac catcagcatt ttgagttttt 840 tctctgtcgc tctgttggtc atcttggcct gtgtgttatg gaaaaaaagg attaagccta 900 tcgtatggcc cagtctcccc gatcataaga agactctgga acatctttgt aagaaaccaa 960 gaaaaaattt aaatgtgagt ttcaatcctg aaagtttcct ggactgccag attcataggg 1020 tggatgacat tcaagctaga gatgaagtgg aaggttttct gcaagatacg tttcctcagc 1080 aactagaaga atctgagaag cagaggcttg gaggggatgt gcagagcccc aactgcccat 1140 ctgaggatgt agtcatcact ccagaaagct ttggaagaga ttcatccctc acatgcctgg 1200 ctgggaatgt cagtgcatgt gacgccccta ttctctcctc ttccaggtcc ctagactgca 1260 gggagagtgg caagaatggg cctcatgtgt accaggacct cctgcttagc cttgggacta 1320 caaacagcac gctgccccct ccattttctc tccaatctgg aatcctgaca ttgaacccag 1380 ttgctcaggg tcagcccatt cttacttccc tgggatcaaa tcaagaagaa gcatatgtca 1440 ccatgtccag cttctaccaa aaccagtgaa gtgtaagaaa cccagactga acttaccgtg 1500 agcgacaaag atgatttaaa agggaagtct agagttccta gtctccctca cagcacagag 1560 aagacaaaat tagcaaaacc ccactacaca gtctgcaaga ttctgaaaca ttgctttgac 1620 cactcttcct gagttcagtg gcactcaaca tgagtcaaga gcatcctgct tctaccatgt 1680 ggatttggtc acaaggttta aggtgaccca atgattcagc tatttaaaaa aaaaagagga 1740 aagaatgaaa gagtaaagga aatgattgag gagtgaggaa ggcaggaaga gagcatgaga 1800 ggaaaaaaa 1809 <210> 87 <211> 2418 <212> DNA <213> Homo sapiens programmed cell death 1 ligand 2 (PDCD1LG2) <400> 87 gcaaacctta agctgaatga acaacttttc ttctcttgaa tatatcttaa cgccaaattt 60 tgagtgcttt tttgttaccc atcctcatat gtcccagcta gaaagaatcc tgggttggag 120 ctactgcatg ttgattgttt tgtttttcct tttggctgtt cattttggtg gctactataa 180 ggaaatctaa cacaaacagc aactgttttt tgttgtttac ttttgcatct ttacttgtgg 240 agctgtggca agtcctcata tcaaatacag aacatgatct tcctcctgct aatgttgagc 300 ctggaattgc agcttcacca gatagcagct ttattcacag tgacagtccc taaggaactg 360 tacataatag agcatggcag caatgtgacc ctggaatgca actttgacac tggaagtcat 420 gtgaaccttg gagcaataac agccagtttg caaaaggtgg aaaatgatac atccccacac 480 cgtgaaagag ccactttgct ggaggagcag ctgcccctag ggaaggcctc gttccacata 540 cctcaagtcc aagtgaggga cgaaggacag taccaatgca taatcatcta tggggtcgcc 600 tgggactaca agtacctgac tctgaaagtc aaagcttcct acaggaaaat aaacactcac 660 atcctaaagg ttccagaaac agatgaggta gagctcacct gccaggctac aggttatcct 720 ctggcagaag tatcctggcc aaacgtcagc gttcctgcca acaccagcca ctccaggacc 780 cctgaaggcc tctaccaggt caccagtgtt ctgcgcctaa agccaccccc tggcagaaac 840 ttcagctgtg tgttctggaa tactcacgtg agggaactta ctttggccag cattgacctt 900 caaagtcaga tggaacccag gacccatcca acttggctgc ttcacatttt catccccttc 960 tgcatcattg ctttcatttt catagccaca gtgatagccc taagaaaaca actctgtcaa 1020 aagctgtatt cttcaaaaga cacaacaaaa agacctgtca ccacaacaaa gagggaagtg 1080 aacagtgcta tctgaacctg tggtcttggg agccagggtg acctgatatg acatctaaag 1140 aagcttctgg actctgaaca agaattcggt ggcctgcaga gcttgccatt tgcacttttc 1200 aaatgccttt ggatgaccca gcactttaat ctgaaacctg caacaagact agccaacacc 1260 tggccatgaa acttgcccct tcactgatct ggactcacct ctggagccta tggctttaag 1320 caagcactac tgcactttac agaattaccc cactggatcc tggacccaca gaattccttc 1380 aggatccttc ttgctgccag actgaaagca aaaggaatta tttcccctca agttttctaa 1440 gtgatttcca aaagcagagg tgtgtggaaa tttccagtaa cagaaacaga tgggttgcca 1500 atagagttat tttttatcta tagcttcctc tgggtactag aagaggctat tgagactatg 1560 agctcacaga cagggcttcg cacaaactca aatcataatt gacatgtttt atggattact 1620 ggaatcttga tagcataatg aagttgttct aattaacaga gagcatttaa atatacacta 1680 agtgcacaaa ttgtggagta aagtcatcaa gctctgtttt tgaggtctaa gtcacaaagc 1740 atttgtttta acctgtaatg gcaccatgtt taatggtggt tttttttttg aactacatct 1800 ttcctttaaa aattattggt ttctttttat ttgtttttac cttagaaatc aattatatac 1860 agtcaaaaat atttgatatg ctcatacgtt gtatctgcag caatttcaga taagtagcta 1920 aaatggccaa agccccaaac taagcctcct tttctggccc tcaatatgac tttaaatttg 1980 acttttcagt gcctcagttt gcacatctgt aatacagcaa tgctaagtag tcaaggcctt 2040 tgataattgg cactatggaa atcctgcaag atcccactac atatgtgtgg agcagaaggg 2100 taactcggct acagtaacag cttaattttg ttaaatttgt tctttatact ggagccatga 2160 agctcagagc attagctgac ccttgaacta ttcaaatggg cacattagct agtataacag 2220 acttacatag gtgggcctaa agcaagctcc ttaactgagc aaaatttggg gcttatgaga 2280 atgaaagggt gtgaaattga ctaacagaca aatcatacat ctcagtttct caattctcat 2340 gtaaatcaga gaatgccttt aaagaataaa actcaattgt tattcttcaa cgttctttat 2400 atattctact tttgggta 2418 <210> 88 <211> 2611 <212> DNA <213> Homo sapiens Bruton agammaglobulinemia tyrosine kinase (BTK) <400> 88 aactgagtgg ctgtgaaagg gtggggtttg ctcagactgt ccttcctctc tggactgtaa 60 gaatatgtct ccagggccag tgtctgctgc gatcgagtcc caccttccaa gtcctggcat 120 ctcaatgcat ctgggaagct acctgcatta agtcaggact gagcacacag gtgaactcca 180 gaaagaagaa gctatggccg cagtgattct ggagagcatc tttctgaagc gatcccaaca 240 gaaaaagaaa acatcacctc taaacttcaa gaagcgcctg tttctcttga ccgtgcacaa 300 actctcctac tatgagtatg actttgaacg tgggagaaga ggcagtaaga agggttcaat 360 agatgttgag aagatcactt gtgttgaaac agtggttcct gaaaaaaatc ctcctccaga 420 aagacagatt ccgagaagag gtgaagagtc cagtgaaatg gagcaaattt caatcattga 480 aaggttccct tatcccttcc aggttgtata tgatgaaggg cctctctacg tcttctcccc 540 aactgaagaa ctaaggaagc ggtggattca ccagctcaaa aacgtaatcc ggtacaacag 600 tgatctggtt cagaaatatc acccttgctt ctggatcgat gggcagtatc tctgctgctc 660 tcagacagcc aaaaatgcta tgggctgcca aattttggag aacaggaatg gaagcttaaa 720 acctgggagt tctcaccgga agacaaaaaa gcctcttccc ccaacgcctg aggaggacca 780 gatcttgaaa aagccactac cgcctgagcc agcagcagca ccagtctcca caagtgagct 840 gaaaaaggtt gtggcccttt atgattacat gccaatgaat gcaaatgatc tacagctgcg 900 gaagggtgat gaatatttta tcttggagga aagcaactta ccatggtgga gagcacgaga 960 taaaaatggg caggaaggct acattcctag taactatgtc actgaagcag aagactccat 1020 agaaatgtat gagtggtatt ccaaacacat gactcggagt caggctgagc aactgctaaa 1080 gcaagagggg aaagaaggag gtttcattgt cagagactcc agcaaagctg gcaaatatac 1140 agtgtctgtg tttgctaaat ccacagggga ccctcaaggg gtgatacgtc attatgttgt 1200 gtgttccaca cctcagagcc agtattacct ggctgagaag caccttttca gcaccatccc 1260 tgagctcatt aactaccatc agcacaactc tgcaggactc atatccaggc tcaaatatcc 1320 agtgtctcaa caaaacaaga atgcaccttc cactgcaggc ctgggatacg gatcatggga 1380 aattgatcca aaggacctga ccttcttgaa ggagctgggg actggacaat ttggggtagt 1440 gaagtatggg aaatggagag gccagtacga cgtggccatc aagatgatca aagaaggctc 1500 catgtctgaa gatgaattca ttgaagaagc caaagtcatg atgaatcttt cccatgagaa 1560 gctggtgcag ttgtatggcg tctgcaccaa gcagcgcccc atcttcatca tcactgagta 1620 catggccaat ggctgcctcc tgaactacct gagggagatg cgccaccgct tccagactca 1680 gcagctgcta gagatgtgca aggatgtctg tgaagccatg gaatacctgg agtcaaagca 1740 gttccttcac cgagacctgg cagctcgaaa ctgtttggta aacgatcaag gagttgttaa 1800 agtatctgat ttcggcctgt ccaggtatgt cctggatgat gaatacacaa gctcagtagg 1860 ctccaaattt ccagtccggt ggtccccacc ggaagtcctg atgtatagca agttcagcag 1920 caaatctgac atttgggctt ttggggtttt gatgtgggaa atttactccc tggggaagat 1980 gccatatgag agatttacta acagtgagac tgctgaacac attgcccaag gcctacgtct 2040 ctacaggcct catctggctt cagagaaggt atataccatc atgtacagtt gctggcatga 2100 gaaagcagat gagcgtccca ctttcaaaat tcttctgagc aatattctag atgtcatgga 2160 tgaagaatcc tgagctcgcc aataagcttc ttggttctac ttctcttctc cacaagcccc 2220 aatttcactt tctcagagga aatcccaagc ttaggagccc tggagccttt gtgctcccac 2280 tcaatacaaa aaggcccctc tctacatctg ggaatgcacc tcttctttga ttccctggga 2340 tagtggcttc tgagcaaagg ccaagaaatt attgtgcctg aaatttcccg agagaattaa 2400 gacagactga atttgcgatg aaaatatttt ttaggaggga ggatgtaaat agccgcacaa 2460 aggggtccaa cagctctttg agtaggcatt tggtagagct tgggggtgtg tgtgtggggg 2520 tggaccgaat ttggcaagaa tgaaatggtg tcataaagat gggaggggag ggtgttttga 2580 taaaataaaa ttactagaaa gcttgaaagt c 2611 <210> 89 <211> 8014 <212> DNA <213> Homo sapiens protein kinase C, beta (PRKCB) <400> 89 agctggacga gcggcagcag ctgggcgagt gacagccccg gctccgcgcg ccgcggccgc 60 cagagccggc gcaggggaag cgcccgcggc cccgggtgca gcagcggccg ccgcctcccg 120 cgcctccccg gcccgcagcc cgcggtcccg cggccccggg gccggcacct ctcgggctcc 180 ggctccccgc gcgcaagatg gctgacccgg ctgcggggcc gccgccgagc gagggcgagg 240 agagcaccgt gcgcttcgcc cgcaaaggcg ccctccggca gaagaacgtg catgaggtca 300 agaaccacaa attcaccgcc cgcttcttca agcagcccac cttctgcagc cactgcaccg 360 acttcatctg gggcttcggg aagcagggat tccagtgcca agtttgctgc tttgtggtgc 420 acaagcggtg ccatgaattt gtcacattct cctgccctgg cgctgacaag ggtccagcct 480 ccgatgaccc ccgcagcaaa cacaagttta agatccacac gtactccagc cccacgtttt 540 gtgaccactg tgggtcactg ctgtatggac tcatccacca ggggatgaaa tgtgacacct 600 gcatgatgaa tgtgcacaag cgctgcgtga tgaatgttcc cagcctgtgt ggcacggacc 660 acacggagcg ccgcggccgc atctacatcc aggcccacat cgacagggac gtcctcattg 720 tcctcgtaag agatgctaaa aaccttgtac ctatggaccc caatggcctg tcagatccct 780 acgtaaaact gaaactgatt cccgatccca aaagtgagag caaacagaag accaaaacca 840 tcaaatgctc cctcaaccct gagtggaatg agacatttag atttcagctg aaagaatcgg 900 acaaagacag aagactgtca gtagagattt gggattggga tttgaccagc aggaatgact 960 tcatgggatc tttgtccttt gggatttctg aacttcagaa agccagtgtt gatggctggt 1020 ttaagttact gagccaggag gaaggcgagt acttcaatgt gcctgtgcca ccagaaggaa 1080 gtgaggccaa tgaagaactg cggcagaaat ttgagagggc caagatcagt cagggaacca 1140 aggtcccgga agaaaagacg accaacactg tctccaaatt tgacaacaat ggcaacagag 1200 accggatgaa actgaccgat tttaacttcc taatggtgct ggggaaaggc agctttggca 1260 aggtcatgct ttcagaacga aaaggcacag atgagctcta tgctgtgaag atcctgaaga 1320 aggacgttgt gatccaagat gatgacgtgg agtgcactat ggtggagaag cgggtgttgg 1380 ccctgcctgg gaagccgccc ttcctgaccc agctccactc ctgcttccag accatggacc 1440 gcctgtactt tgtgatggag tacgtgaatg ggggcgacct catgtatcac atccagcaag 1500 tcggccggtt caaggagccc catgctgtat tttacgctgc agaaattgcc atcggtctgt 1560 tcttcttaca gagtaagggc atcatttacc gtgacctaaa acttgacaac gtgatgctcg 1620 attctgaggg acacatcaag attgccgatt ttggcatgtg taaggaaaac atctgggatg 1680 gggtgacaac caagacattc tgtggcactc cagactacat cgcccccgag ataattgctt 1740 atcagcccta tgggaagtcc gtggattggt gggcatttgg agtcctgctg tatgaaatgt 1800 tggctgggca ggcacccttt gaaggggagg atgaagatga actcttccaa tccatcatgg 1860 aacacaacgt agcctatccc aagtctatgt ccaaggaagc tgtggccatc tgcaaagggc 1920 tgatgaccaa acacccaggc aaacgtctgg gttgtggacc tgaaggcgaa cgtgatatca 1980 aagagcatgc atttttccgg tatattgatt gggagaaact tgaacgcaaa gagatccagc 2040 ccccttataa gccaaaagct tgtgggcgaa atgctgaaaa cttcgaccga tttttcaccc 2100 gccatccacc agtcctaaca cctcccgacc aggaagtcat caggaatatt gaccaatcag 2160 aattcgaagg attttccttt gttaactctg aatttttaaa acccgaagtc aagagctaag 2220 tagatgtgta gatctccgtc cttcatttct gtcattcaag ctcaacggct attgtggtga 2280 catttttatg tttttcattg ccaagttgca tccatgtttg attttctgat gagactagag 2340 tgacagtgtt tcagaaccca aatgtcctca ggtagtttgg agcatctcta tgagatggga 2400 ttatgcagat ggcctatgga aaatgcagct gcataattaa cacattatca aagtcctctt 2460 acaatttatt ttccgcagca tgtcagctaa gtagacccaa tggggagaga aaatgcctgc 2520 tttctttccc tctttttctg cactgccata ttcaccccca accatccaat ctgtggataa 2580 ttggatgtta gcggtactct tccacttccg ggcctggagc ttggcttgta tccaagtgta 2640 tggttgcttt gcctaagagg aatccctcta tttcacctgt tctggaggca ccagaccttg 2700 aaaagaacat gctcaaaata aaatgttatc tgttattttt gtaaactcaa agttaagatg 2760 atcaaagttc taaaattcca agaatgtgct tttagacggt ctcaatctaa aagcacttca 2820 aggggtcaaa gggcaaccag cttgggtgct acctcagtgt tgtagtttct gatactttat 2880 gtctttgctc accctcatcc ccaaactact tgaaaagggc atttggcacc actctctgaa 2940 acaacacagt cactctagca aggcccccaa agggccctgg ttttacatta catttcaaac 3000 tttatttgct ttggggtttt gtttctgttg ttgttcaaat gcaaaaaaaa gaaaaaaaaa 3060 gaaaaaaaaa ggtgactcac attgttacac atgctttaaa atatgtattc aaatgttatt 3120 aaccacaatg acgacctgct ttgatttaac caagaagacg gctgcggagc ctagcagact 3180 caggcctgtg ggaatgggat ttgttacaaa tctaggtttg ttactggctt cagaaagcta 3240 attaagtgct ctgaaaaaga caccgtttct tgaaacaaag atggttgtat tcctcacttt 3300 gatgttgttt tgcaagatgt ttgtggaaat gttcatttgt atctggatct ctgttatgtg 3360 ccatttttct tctagcatcg agatacaata aaaaaaaaaa aaaagaaaag aagaagaaat 3420 actatttcaa ggaaaactgc tctttttgag aaacgtggac ctaaactaca aagtgggaac 3480 tgaggaggga actcaggaga aaggaactaa ctgcggagct ttaatcttgg ccccagtgtt 3540 cagccactcg gaggggcggg ggctgtggcc cattcagggg ctgctggtgg gctgtagtgg 3600 ggtgggatga cctggccaga gccaacgagg atactggagc ccaaagtcaa gtttagagac 3660 cagctgggaa cgtgaatggg gctcttgatt ttcttatcaa aatcaccact cctcccagct 3720 tggactaaat attctttcta gcaagcagct ttgtgagctc cctgaagccc aaggaaaccc 3780 ttcggtggga gaaatttcat ttctgtctga gaggattaag gcagcaggtg actccccctc 3840 ctcgcctgcc gtgtcctgct attctcaggc agctctaagg agaattctta tcacagttca 3900 agtgatttcc agaagttcca gggcttctga gagaccatca agggaacttt aacaacttga 3960 caaatgtcct tgaagtaaga tgcctcatct ttagggaaaa atggggtttg gatttctgct 4020 taggcaaagt ctcctgcagt tcatccttct ctgtcctctt cttgcttcag gcttggggac 4080 cgtccctgct gtccccactg tggtggcaat caggacctaa ggtgaagcaa acttgaagtt 4140 ctatctgaca agtttaggca gtaagagaag gagggaaatc ggagcaaagc tccctcactt 4200 tattgttgag aaactggcat ctggaaagag gaaggaattt gcccaaagtc agtcagctgg 4260 gataaaaacc tgggtgtcct gtccagaaag tgcagggtgc tttctgctct gtagcaaggc 4320 agcagacatc tctgagccag gcccaccaac aggcccttat ctggtggttg gatcatgatc 4380 ccattttgct tggacatgct ctcaggaaga taaaaaccat ggagaaacac taggccattg 4440 acaaatgatc tgagacaact ttagaaaaca atgtaggatg aatggaaaga gaaagaaagg 4500 aaagaaagaa gaaaaagaaa gaaggaaaga aagaaagaga aaggaaggaa ggaaagaagg 4560 aaggaaaaga aggaaggaag gaaggaatat agtgttataa atactgcact caacattttc 4620 caaattcttg ccattatttt tcaaaagttt aatagtttgc agaaatagat actcaagcca 4680 aagtctgttt tagagaaact ttccatggaa agtcagaatt tctaccactt ccttttctat 4740 ccacatttcc agtgcagaag aaactgagaa acagagcttt ttgaagagag gacagggcca 4800 tagcaacaag gaccttcttg ggggattaat gggaggtcag tagaattaat aaccctcctt 4860 ggatgagtgc tactgttttc acatggcttc agatgctatc aacctcaaag aaatgatctc 4920 aacagagaag cttattctct cccaacttct acggtaaaat ccaggagtat tttctctggg 4980 gatctgccca caggacaaag tccataaaag caagtcctgt ctggaccatg tggttatctg 5040 aagcattagc catcaccagc acaacaaacg gggcagggct ttccaaggtg gggctggtca 5100 gaagggaatc tttgataaga ggcccacagg cagggaaagc gaaatagggt tgatgagacc 5160 aggggagacc taaaaaaaag gcagctttgt gtcttctagc tccaaatata cctgcctttt 5220 agctcacaca ctgtcctgga gttctcagac ctttaggggc cctaacacag ttcagttcat 5280 acaggggttc aaaagggaca gtggcccatt tgggagacct ttaggatcaa tgggaatcaa 5340 ttccattgtt ttgcctcaga gtaaagtttc tggctcgggg acaattataa gttgcaaaaa 5400 ggatagaggc atatcccaag tcttccttca ttccacaaat aattacaaac aacctactgt 5460 gtgccaggca ctattcttag cactggaaat acactagtga agaagcagat gaggaccctg 5520 tttattgttt ctctccaaga aattctccaa gaatattgtt tcttggagag aaataataaa 5580 taaacaagac aatttctgaa agcaataagt gcaatcaaga taattaaagg atgctaaagt 5640 gtgacttgtg gggattggga gagagatgca cagacaatat taaagaggag gcattcgagc 5700 tttgttgtga acaccggaag taacatgccg agcgcctggg ggatggaaac tcctatagca 5760 ccccacaggc taacagcaag caggacaaga caaaaagggc aggtgggaca tggtagagat 5820 ggaccctacc caggaaacag ctccatcagc atcttagcct gccccactct agccacacat 5880 acccacgtgt gctcctgagt tcagtgtgcc cacctcactc ccacaccctc acatagactt 5940 ggcaagagta aggagggaac tccatagaga cattttacct atctcagggg agcagccaca 6000 aagaagcaag tcttgtaaaa ggtcttttgc aaaggagagt gaacccagca atgagagatc 6060 cttaacagct agtgcccatt agggggctaa acctaaagcc tgggtggtga tggctcaaac 6120 gctaatgagt cagtgaatcc ttaccgaccc cctggccttt ataatctgag gcaactttgg 6180 ctgcagcccg ggaatgtgca gggcactagg gaatacaagg ccttcttccc tggttgtctt 6240 gtaataaaac agccatgggg ttgtccctcc agtccgagag actgtgatga ggcctacata 6300 gcagcgatgt ggtcaggtaa aaatcaggaa cccactgaaa tcttgggcaa gccaccctgc 6360 ctgcttgtgc ctcggttctc tcatatgtca tatataggag gtgaggactc cagctccacc 6420 tgccccaggt gggtgtggtg atgatgagga aagacaagag gcttgcaagg accctgaaga 6480 ggtcggagca tcatacagat tcctttatta gcccacattc tgatgttccc tggtgagact 6540 tgccccaagc aattgctagt aaatgggggt taatttcttc tccacctccc tactgaacaa 6600 aaaaagaaat gccagactta ctaggagaat cgagttgctt tgagtttctt ttgttttgtt 6660 ttgttttgtt ttgttttaag gctcccctta cacaccctcc tttaagcttt gggttttctc 6720 tcttatagtt tgttgacaca tgctaaaaat gtctttggag agaacttctg cctgataaac 6780 acccaattct agactgtggg tggattttcg agctgacggt ggtcaattcc tttcattaag 6840 cagtgatctg atttctccac atggccattc tgccttcttg ggggcagagt agatgggcag 6900 cagttcacct tttcagagaa agaggtcttc tagccacctg ggctgctact gaatggtttt 6960 ctccaggacg ctctacctaa tgattatttc tataacatta agcatggtaa taagtagctt 7020 ccaattcaat tcatcctaaa gccaaagaaa atacagcaac acacacacac acacacacac 7080 acacacacac acacacacac acacaccact ttatggcaat tcttaactga cattcaatga 7140 cttacttctt ttcttagaaa atttccacca catttctatc cccaagccaa catacaatgt 7200 gaaatgaaag ccagtgcgtg gagtgcagct gctaaaaatt ttcagcacag ggctctttct 7260 gactctgctc atgagatggt atcagccacc caatgactgg cgtatcttgg tcctgtgtct 7320 ttcttcttac gctgtgttaa tgtgtttact ttccatttgg cagagagaca agagagacac 7380 ctccaacttc gacaaagagt tcaccagaca gcctgtggaa ctgaccccca ctgataaact 7440 cttcatcatg aacttggacc aaaatgaatt tgctggcttc tcttatacta acccagagtt 7500 tgtcattaat gtgtaggtga atgcaaactc catcgttgag cctggggtgt aagacttcaa 7560 gccaagcgta tgtatcaatt ctagtcttcc aggattcacg gtgcacatgc tggcattcaa 7620 catgtggaaa gcttgtctta gagggctttt ctttgtatgt gtagcttgct agtttgtttt 7680 ctacatttga aaatgtttag tttagaataa gcgcattatc caattataga ggtacaattt 7740 tccaaacttc cagaaactca tcaaatgaac agacaatgtc aaaactactg tgtctgatac 7800 caaaatgctt cagtatttgt aatttttcaa gtcagaagct gatgttcctg gtaaaagttt 7860 ttacagttat tctataatat cttctttgaa tgctaagcat gagcgatatt tttaaaaatt 7920 gtgagtaagc tttgcagtta ctgtgaacta ttgtctcttg gaggaagttt tttgtttaag 7980 aattgatatg attaaactga attaatatat gcaa 8014 <210> 90 <211> 2228 <212> DNA <213> Homo sapiens bridging integrator 2 (BIN2) <400> 90 agaaaaccac agggcgcggg gccagggcgg cggcccccag ggagttggca ggatggcaga 60 gggcaaggca ggcggcgcgg ccggcctctt cgccaagcag gtgcagaaga agtttagcag 120 ggcccaggag aaggtgctgc agaaattggg gaaagctgta gaaaccaaag atgaacgatt 180 tgaacaaagc gctagcaact tctaccaaca acaggcagaa ggccacaagc tgtacaagga 240 cctgaagaac ttccttagtg cagtcaaagt gatgcatgaa agttcaaaaa gagtgtcaga 300 aaccctgcag gagatctaca gcagcgagtg ggacggtcat gaggagctga aggccatcgt 360 atggaataat gatctccttt gggaagacta cgaggagaaa ctggctgacc aggctgtaag 420 gaccatggaa atctatgttg cccagttcag tgaaattaag gagagaattg ccaagcgggg 480 tcggaaactc gtggactatg acagtgcccg acaccacctg gaggcagtgc agaatgccaa 540 gaagaaagat gaggccaaga ctgccaaggc agaggaagag ttcaacaaag cccagactgt 600 gtttgaagat ctgaaccaag aactactaga ggagctgcct attctttata atagtcgtat 660 tggctgctat gtgaccatct tccaaaacat ttccaacttg agggatgtct tctacaggga 720 aatgagcaag ctgaaccaca atctctacga ggtgatgagc aaactggaga agcaacattc 780 caataaagtc tttgtggtga agggactgtc aagcagcagc aggcgctctt tagtcatttc 840 tcccccagtt cgaacagcta cagtctccag tcctcttacc tcacctacta gtccctctac 900 actttccttg aagagtgaga gtgaatctgt ctcagcaact gaagatctgg cacctgatgc 960 agcccaaggg gaagacaatt ctgagatcaa ggagctctta gaagaggagg aaatagagaa 1020 ggaaggatct gaagcaagct cctctgagga agatgagcct ctaccagcct gcaatggccc 1080 cgcccaggcc cagccctctc ctaccactga aagggccaag tcccaggagg aagttctccc 1140 cagctccaca actccatcac caggcggagc cctgagccct tcagggcagc cttcatcatc 1200 tgccacagaa gtagtcctcc gaacccgcac cgcaagtgaa ggatctgaac aaccaaagaa 1260 gagagcctct atccagagga cctcagcacc ccctagtagg cctcctccac ccagagccac 1320 tgcaagcccc aggccctcct cagggaacat accttccagc cctacagcct ctggaggggg 1380 ttcacccacc agccctaggg cctccttggg gactgggact gcaagtccta ggacctccct 1440 agaggtctct cctaatccag aaccaccaga gaagccagta agaactcctg aggccaaaga 1500 aaatgaaaac atccacaatc agaaccctga agaactttgt acttccccca ccttaatgac 1560 atctcaggtt gcttcagagc ctggagaggc aaagaagatg gaagacaagg aaaaggataa 1620 taagcttatc tcagctaact cctcggaggg ccaagaccag cttcaagtct ccatggtacc 1680 agaaaacaac aacctcacag cacctgaacc tcaagaagag gtatccacaa gtgaaaatcc 1740 acaactctga agagaaacta ccaagactcc tcctgcccca aacctcgcca gagaagctct 1800 tcaaccagag ggtataggtc agagggatat aagagccagc atccatccct gggttctcag 1860 taggaatgct ggtgctgtct aaagacctgg cattaatgga ggcggaggag cagccttacg 1920 ggagggatgg agggaggcag gctggggaga agagaacatt agactcaggg aatatttaat 1980 tctggtttta gcattattag aataagactt tatacattaa ctaaagtgga gctttaatca 2040 ctataaaaag caaaagtatc tatagacaca gacacttgcc tatacagaga cataaccaca 2100 cacactcaga ggatagtgaa caaatctgtc tttgacttac gacccatttt gcaagactta 2160 aagccggaag aacacatttt cagattgtta aataaagtct gattctgact aaaaaaaaaa 2220 aaaaaaaa 2228 <210> 91 <211> 1779 <212> DNA <213> Homo sapiens carboxypeptidase, vitellogenic-like (CPVL) <400> 91 gtgactgggt ggggctgcct cacttctgcc tgatttggga agcgctgcaa ggacaaccgg 60 ctggggtcct tgcgcgccgc ggctcaggga ggagcaccga ctgcgccgcg taagtgccgc 120 ctgccctgcg tgggtcgtgc cagctcagcg ggacaggtcc tcgcctcggt ccctcggact 180 tagggagcgc ggggcagacc ctgagagatg gttggtgcca tgtggaaggt gattgtttcg 240 ctggtcctgt tgatgcctgg cccctgtgat gggctgtttc gctccctata cagaagtgtt 300 tccatgccac ctaagggaga ctcaggacag ccattatttc tcacccctta cattgaagct 360 gggaagatcc aaaaaggaag agaattgagt ttggtcggcc ctttcccagg actgaacatg 420 aagagttatg ccggcttcct caccgtgaat aagacttaca acagcaacct cttcttctgg 480 ttcttcccag ctcagataca gccagaagat gccccagtag ttctctggct acagggtggg 540 ccgggaggtt catccatgtt tggactcttt gtggaacatg ggccttatgt tgtcacaagt 600 aacatgacct tgcgtgacag agacttcccc tggaccacaa cgctctccat gctttacatt 660 gacaatccag tgggcacagg cttcagtttt actgatgata cccacggata tgcagtcaat 720 gaggacgatg tagcacggga tttatacagt gcactaattc agtttttcca gatatttcct 780 gaatataaaa ataatgactt ttatgtcact ggggagtctt atgcagggaa atatgtgcca 840 gccattgcac acctcatcca ttccctcaac cctgtgagag aggtgaagat caacctgaac 900 ggaattgcta ttggagatgg atattctgat cccgaatcaa ttataggggg ctatgcagaa 960 ttcctgtacc aaattggctt gttggatgag aagcaaaaaa agtacttcca gaagcagtgc 1020 catgaatgca tagaacacat caggaagcag aactggtttg aggcctttga aatactggat 1080 aaactactag atggcgactt aacaagtgat ccttcttact tccagaatgt tacaggatgt 1140 agtaattact ataacttttt gcggtgcacg gaacctgagg atcagcttta ctatgtgaaa 1200 tttttgtcac tcccagaggt gagacaagcc atccacgtgg ggaatcagac ttttaatgat 1260 ggaactatag ttgaaaagta cttgcgagaa gatacagtac agtcagttaa gccatggtta 1320 actgaaatca tgaataatta taaggttctg atctacaatg gccaactgga catcatcgtg 1380 gcagctgccc tgacagagcg ctccttgatg ggcatggact ggaaaggatc ccaggaatac 1440 aagaaggcag aaaaaaaagt ttggaagatc tttaaatctg acagtgaagt ggctggttac 1500 atccggcaag cgggtgactt ccatcaggta attattcgag gtggaggaca tattttaccc 1560 tatgaccagc ctctgagagc ttttgacatg attaatcgat tcatttatgg aaaaggatgg 1620 gatccttatg ttggataaac taccttccca aaagagaaca tcagaggttt tcattgctga 1680 aaagaaaatc gtaaaaacag aaaatgtcat aggaataaaa aaattatctt ttcatatctg 1740 caagattttt ttcatcaata aaaattatcc ttgaaacaa 1779 <210> 92 <211> 4366 <212> DNA <213> Homo sapiens IL2-inducible T-cell kinase (ITK) <400> 92 tgcattcttt gccccaaaac tctttccttt ggttgtgcta agaggtgatg cccaaggtgc 60 accacctttc aagaactgga tcatgaacaa ctttatcctc ctggaagaac agctcatcaa 120 gaaatcccaa caaaagagaa gaacttctcc ctcgaacttt aaagtccgct tctttgtgtt 180 aaccaaagcc agcctggcat actttgaaga tcgtcatggg aagaagcgca cgctgaaggg 240 gtccattgag ctctcccgaa tcaaatgtgt tgagattgtg aaaagtgaca tcagcatccc 300 atgccactat aaatacccgt ttcaggtggt gcatgacaac tacctcctat atgtgtttgc 360 tccagatcgt gagagccggc agcgctgggt gctggccctt aaagaagaaa cgaggaataa 420 taacagtttg gtgcctaaat atcatcctaa tttctggatg gatgggaagt ggaggtgctg 480 ttctcagctg gagaagcttg caacaggctg tgcccaatat gatccaacca agaatgcttc 540 aaagaagcct cttcctccta ctcctgaaga caacaggcga ccactttggg aacctgaaga 600 aactgtggtc attgccttat atgactacca aaccaatgat cctcaggaac tcgcactgcg 660 gcgcaacgaa gagtactgcc tgctggacag ttctgagatt cactggtgga gagtccagga 720 caggaatggg catgaaggat atgtaccaag cagttatctg gtggaaaaat ctccaaataa 780 tctggaaacc tatgagtggt acaataagag tatcagccga gacaaagctg aaaaacttct 840 tttggacaca ggcaaagaag gagccttcat ggtaagggat tccaggactg caggaacata 900 caccgtgtct gttttcacca aggctgttgt aagtgagaac aatccctgta taaagcatta 960 tcacatcaag gaaacaaatg acaatcctaa gcgatactat gtggctgaaa agtatgtgtt 1020 cgattccatc cctcttctca tcaactatca ccaacataat ggaggaggcc tggtgactcg 1080 actccggtat ccagtttgtt ttgggaggca gaaagcccca gttacagcag ggctgagata 1140 cgggaaatgg gtgatcgacc cctcagagct cacttttgtg caagagattg gcagtgggca 1200 atttgggttg gtgcatctgg gctactggct caacaaggac aaggtggcta tcaaaaccat 1260 tcgggaaggg gctatgtcag aagaggactt catagaggag gctgaagtaa tgatgaaact 1320 ctctcatccc aaactggtgc agctgtatgg ggtgtgcctg gagcaggccc ccatctgcct 1380 ggtgtttgag ttcatggagc acggctgcct gtcagattat ctacgcaccc agcggggact 1440 ttttgctgca gagaccctgc tgggcatgtg tctggatgtg tgtgagggca tggcctacct 1500 ggaagaggca tgtgtcatcc acagagactt ggctgccaga aattgtttgg tgggagaaaa 1560 ccaagtcatc aaggtgtctg actttgggat gacaaggttc gttctggatg atcagtacac 1620 cagttccaca ggcaccaaat tcccggtgaa gtgggcatcc ccagaggttt tctctttcag 1680 tcgctatagc agcaagtccg atgtgtggtc atttggtgtg ctgatgtggg aagttttcag 1740 tgaaggcaaa atcccgtatg aaaaccgaag caactcagag gtggtggaag acatcagtac 1800 cggatttcgg ttgtacaagc cccggctggc ctccacacac gtctaccaga ttatgaatca 1860 ctgctggaaa gagagaccag aagatcggcc agccttctcc agactgctgc gtcaactggc 1920 tgaaattgca gaatcaggac tttagtagag actgagtacc aggccacggg ctgcagatcc 1980 tgaatggagg aaggatatgt cctcattcca tagagcatta gaagctgcca ccagcccagg 2040 accctccaga ggcagcctgg cctgtggcat cagtccctga gtcaccatgg aagcagcatc 2100 ctgaccacag ctggcagtca agccacagct ggagggtcag ccaccaagct gggagctgag 2160 ccagaacagg agtgatgtct ctgcccttcc tctagcctct tgtcacatgt ggtgcacaaa 2220 cctcaacctg acagctttca gacagcattc ttgcacttct tagcaacaga gagagacatg 2280 agtaagaccc agattgctat ttttattgtt atttttaaca tgaatctaaa gtttatggtt 2340 ccagggactt tttatttgac ccaacaacac agtatcccag gatatggagg caaggggaac 2400 aaagagcatg agtctttttc caagaaaact ggtgagttaa gtaagattag agtgagtgtg 2460 ctctgttgct gtgatgctgt cagccacagc ttcctgccgt agagaatgat agagcagctg 2520 ctcacacagg aggccggata ttctgagaag cagctttatg aggttttaca gagtatgctg 2580 ctacctctct ccttgaaggg agcatggcga gacccattgg atggattggg gtgaacagtt 2640 caggtcccat gcttggagca ttgggtatct gatgtctgca ccagaacaag agaacctctg 2700 acggtggaga accatgtggt gcaagaagag atcttaggtc tcttctttta taccaagctc 2760 atcttttata ccaagctgtg caggtgacta tgcctcctct tctgcacaga atgcttccac 2820 cagcatcctg agaagaaatg attacttctg aaaaacatcc ttttttccag cctctgggaa 2880 tcagcccccc ctctctgcac tatccgatcc tcatcaacag agggcagcat tgtgttggtc 2940 aatgttccct tggcgagcaa ttgaaacttg tttaggccct agggttgagc aattttaagg 3000 ttgagactcc aagtctccta aaattctagg agagaaataa agagtctgtt tttgctcaaa 3060 ccatcaggat ggaaacagtc aggcactgac tggggtgctt ccaagaggca tgagagtgcc 3120 tactctggct tgagcacttc tatatgcaag gtgaatatgt actgagctag gagacttccc 3180 tgcaaaatct ctgttcaccc tgggttcaca tccccatgag gtaatattat tattcccatt 3240 ttacaaataa tgtaactgag gctttaaaaa gccaagacat ctgcccaaag tgatggaact 3300 agaaagtcta gagctggtat tctagcccaa atctgtctga ccgcaataca cagattcttt 3360 attcctattc gacactggct tctactgaaa atgaaacgga ttgcagaggg aataaataca 3420 aagatggaaa gccagtaaag aagtcagtat agaaccacta gcgaatagtg ttgctctggc 3480 acagaccact gtggttgatg gcatggccct ccaacttgga ataggatttt ccttttccta 3540 ttctgtatcc ttaccttggt catgttaatg actttggagt tattcagtta atgacccttt 3600 aattctcaca accaaccagt catgttgctt gaagccattt atagacgagc ttcaaagcaa 3660 ctttaaaaga ttcttctgta gaagtatgag ttcttccttt aattatcatt ccaactttca 3720 gctgtagtct tcttgaacac ttcatgagga gggacattcc ctgatataag agaggatggt 3780 gttgcaattg gctctttcta aatcatgtga cgttttgact ggcttgagat tcagatgcat 3840 aatttttaat tataattatt gtgaagtgga gagcctcaag ataaaactct gtcattcaga 3900 agatgatttt actcagctta tccaaaatta tctctgttta ctttttagaa ttttgtacat 3960 tatcttttgg gatccttaat tagagatgat ttctggaaca ttcagtctag aaagaaaaca 4020 ttggaattga ctgatctctg tggtttggtt tagaaaattc ccctgtgcat ggtattacct 4080 ttttcaagct cagattcatc taatcctcaa ctgtacatgt gtacattctt cacctcctgg 4140 tgccctatcc cgcaaaatgg gcttcctgcc tggtttttct cttctcacat tttttaaatg 4200 gtcccctgtg tttgtagaga actcccttat acagagtttt ggttctagtt ttatttcgta 4260 gattttgcat tttgtacctt ttgagactat gtatttatat ttggatcaga tgcatattta 4320 ttaatgtaca gtcactgcta gtgttcaaaa taaaaatgtt acaaat 4366 <210> 93 <211> 2784 <212> DNA <213> Homo sapiens CD86 molecule (CD86) <400> 93 ggaaggcttg cacagggtga aagctttgct tctctgctgc tgtaacaggg actagcacag 60 acacacggat gagtggggtc atttccagat attaggtcac agcagaagca gccaaaatgg 120 atccccagtg cactatggga ctgagtaaca ttctctttgt gatggccttc ctgctctctg 180 gtgctgctcc tctgaagatt caagcttatt tcaatgagac tgcagacctg ccatgccaat 240 ttgcaaactc tcaaaaccaa agcctgagtg agctagtagt attttggcag gaccaggaaa 300 acttggttct gaatgaggta tacttaggca aagagaaatt tgacagtgtt cattccaagt 360 atatgggccg cacaagtttt gattcggaca gttggaccct gagacttcac aatcttcaga 420 tcaaggacaa gggcttgtat caatgtatca tccatcacaa aaagcccaca ggaatgattc 480 gcatccacca gatgaattct gaactgtcag tgcttgctaa cttcagtcaa cctgaaatag 540 taccaatttc taatataaca gaaaatgtgt acataaattt gacctgctca tctatacacg 600 gttacccaga acctaagaag atgagtgttt tgctaagaac caagaattca actatcgagt 660 atgatggtgt tatgcagaaa tctcaagata atgtcacaga actgtacgac gtttccatca 720 gcttgtctgt ttcattccct gatgttacga gcaatatgac catcttctgt attctggaaa 780 ctgacaagac gcggctttta tcttcacctt tctctataga gcttgaggac cctcagcctc 840 ccccagacca cattccttgg attacagctg tacttccaac agttattata tgtgtgatgg 900 ttttctgtct aattctatgg aaatggaaga agaagaagcg gcctcgcaac tcttataaat 960 gtggaaccaa cacaatggag agggaagaga gtgaacagac caagaaaaga gaaaaaatcc 1020 atatacctga aagatctgat gaagcccagc gtgtttttaa aagttcgaag acatcttcat 1080 gcgacaaaag tgatacatgt ttttaattaa agagtaaagc ccatacaagt attcattttt 1140 tctacccttt cctttgtaag ttcctgggca acctttttga tttcttccag aaggcaaaaa 1200 gacattacca tgagtaataa gggggctcca ggactccctc taagtggaat agcctccctg 1260 taactccagc tctgctccgt atgccaagag gagactttaa ttctcttact gcttcttttc 1320 acttcagagc acacttatgg gccaagccca gcttaatggc tcatgacctg gaaataaaat 1380 ttaggaccaa tacctcctcc agatcagatt cttctcttaa tttcatagat tgtgtttttt 1440 ttttaaatag acctctcaat ttctggaaaa ctgcctttta tctgcccaga attctaagct 1500 ggtgccccac tgaattttgt gtgtacctgt gactaaacaa ctacctcctc agtctgggtg 1560 ggacttatgt atttatgacc ttatagtgtt aatatcttga aacatagaga tctatgtact 1620 gtaatagtgt gattactatg ctctagagaa aagtctaccc ctgctaagga gttctcatcc 1680 ctctgtcagg gtcagtaagg aaaacggtgg cctagggtac aggcaacaat gagcagacca 1740 acctaaattt ggggaaatta ggagaggcag agatagaacc tggagccact tctatctggg 1800 ctgttgctaa tattgaggag gcttgcccca cccaacaagc catagtggag agaactgaat 1860 aaacaggaaa atgccagagc ttgtgaaccc tgtttctctt gaagaactga ctagtgagat 1920 ggcctgggga agctgtgaaa gaaccaaaag agatcacaat actcaaaaga gagagagaga 1980 gaaaaaagag agatcttgat ccacagaaat acatgaaatg tctggtctgt ccaccccatc 2040 aacaagtctt gaaacaagca acagatggat agtctgtcca aatggacata agacagacag 2100 cagtttccct ggtggtcagg gaggggtttt ggtgataccc aagttattgg gatgtcatct 2160 tcctggaagc agagctgggg agggagagcc atcaccttga taatgggatg aatggaagga 2220 ggcttaggac tttccactcc tggctgagag aggaagagct gcaacggaat taggaagacc 2280 aagacacaga tcacccgggg cttacttagc ctacagatgt cctacgggaa cgtgggctgg 2340 cccagcatag ggctagcaaa tttgagttgg atgattgttt ttgctcaagg caaccagagg 2400 aaacttgcat acagagacag atatactggg agaaatgact ttgaaaacct ggctctaagg 2460 tgggatcact aagggatggg gcagtctctg cccaaacata aagagaactc tggggagcct 2520 gagccacaaa aatgttcctt tattttatgt aaaccctcaa gggttataga ctgccatgct 2580 agacaagctt gtccatgtaa tattcccatg tttttaccct gcccctgcct tgattagact 2640 cctagcacct ggctagtttc taacatgttt tgtgcagcac agtttttaat aaatgcttgt 2700 tacattcaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 2760 aaaaaaaaaa aaaaaaaaaa aaaa 2784 <210> 94 <211> 1676 <212> DNA <213> Homo sapiens CD69 molecule (CD69) <400> 94 agactcaaca agagctccag caaagacttt cactgtagct tgacttgacc tgagattaac 60 tagggaatct tgagaataaa gatgagctct gaaaattgtt tcgtagcaga gaacagctct 120 ttgcatccgg agagtggaca agaaaatgat gccaccagtc cccatttctc aacacgtcat 180 gaagggtcct tccaagttcc tgtcctgtgt gctgtaatga atgtggtctt catcaccatt 240 ttaatcatag ctctcattgc cttatcagtg ggccaataca attgtccagg ccaatacaca 300 ttctcaatgc catcagacag ccatgtttct tcatgctctg aggactgggt tggctaccag 360 aggaaatgct actttatttc tactgtgaag aggagctgga cttcagccca aaatgcttgt 420 tctgaacatg gtgctactct tgctgtcatt gattctgaaa aggacatgaa ctttctaaaa 480 cgatacgcag gtagagagga acactgggtt ggactgaaaa aggaacctgg tcacccatgg 540 aagtggtcaa atggcaaaga atttaacaac tggttcaacg ttacagggtc tgacaagtgt 600 gtttttctga aaaacacaga ggtcagcagc atggaatgtg agaagaattt atactggata 660 tgtaacaaac cttacaaata ataaggaaac atgttcactt attgactatt atagaatgga 720 actcaaggaa atctgtgtca gtggatgctg ctctgtggtc cgaagtcttc catagagact 780 ttgtgaaaaa aaattttata gtgtcttggg aattttcttc caaacagaac tatggaaaaa 840 aaggaagaaa ttccaggaaa atctgcactg tgggctttta ttgccatgag ctagaagcat 900 cacaggttga ccaataacca tgcccaagaa tgagaagaat gactatgcaa cctttggatg 960 cactttatat tattttgaat ccagaaataa tgaaataact aggcgtggac ttactattta 1020 ttgctgaatg actaccaaca gtgagagccc ttcatgcatt tgcactattg gaaggagtta 1080 gatgttggta ctagatactg aatgtaaaca aaggaattat ggctggtaac ataggttttt 1140 agtctaattg aatcccttaa actcagggag catttataaa tggacaaatg cttatgaaac 1200 taagatttgt aatatttctc tctttttaga gaaatttgcc aatttacttt gttatttttc 1260 cccaaaaaga atgggatgat catgtattta tttttttact tcctcagctg tagacaggtc 1320 cttttcgatg gtacatattt ctttgccttt ataatctttt atacagtgtc ttacagagaa 1380 aagacataag caaagactat gaggaatatt tgcaagacat agaatagtgt tggaaaatgt 1440 gcaatatgtg atgtggcaaa tctctattag gaaatattct gtaatcttca gacctagaat 1500 aatactagtc ttataatagg tttgtgactt tcctaaatca attctattac gtgcaatact 1560 tcaatacttc atttaaaata tttttatgtg caataaaatg tatttgtttg tattttgtgt 1620 tcagtacaat tataagctgt ttttatatat gtgaaataaa agtagaataa acacaa 1676 <210> 95 <211> 1074 <212> DNA <213> Homo sapiens granzyme K (granzyme 3; tryptase II) (GZMK) <400> 95 gatcaacaca tttcatctgg gcttcttaaa tctaaatctt taaaatgact aagttttctt 60 ccttttctct gtttttccta atagttgggg cttatatgac tcatgtgtgt ttcaatatgg 120 aaattattgg agggaaagaa gtgtcacctc attccaggcc atttatggcc tccatccagt 180 atggcggaca tcacgtttgt ggaggtgttc tgattgatcc acagtgggtg ctgacagcag 240 cccactgcca atatcggttt accaaaggcc agtctcccac tgtggtttta ggcgcacact 300 ctctctcaaa gaatgaggcc tccaaacaaa cactggagat caaaaaattt ataccattct 360 caagagttac atcagatcct caatcaaatg atatcatgct ggttaagctt caaacagccg 420 caaaactcaa taaacatgtc aagatgctcc acataagatc caaaacctct cttagatctg 480 gaaccaaatg caaggttact ggctggggag ccaccgatcc agattcatta agaccttctg 540 acaccctgcg agaagtcact gttactgtcc taagtcgaaa actttgcaac agccaaagtt 600 actacaacgg cgaccctttt atcaccaaag acatggtctg tgcaggagat gccaaaggcc 660 agaaggattc ctgtaagggt gactcagggg gccccttgat ctgtaaaggt gtcttccacg 720 ctatagtctc tggaggtcat gaatgtggtg ttgccacaaa gcctggaatc tacaccctgt 780 taaccaagaa ataccagact tggatcaaaa gcaaccttgt cccgcctcat acaaattaag 840 ttacaaataa ttttattgga tgcacttgct tcttttttcc taatatgctc gcaggttaga 900 gttgggtgta agtaaagcag agcacatatg gggtccattt ttgcacttgt aagtcatttt 960 attaaggaat caagttcttt ttcacttgta tcactgatgt atttctacca tgctggtttt 1020 attctaaata aaatttagaa gactcaaaaa aaaaaaaaaa aaaaaaaaaa aaaa 1074 <210> 96 <211> 2523 <212> DNA <213> Homo sapiens SH2 domain containing 1A (SH2D1A) <400> 96 attactaagc atccccgtct gagtgcaagg gtgtgtgttg gcagtacagc cccaatcttg 60 caaaatcctt cttccaatgt tcctcccctc tctgtatgaa ccctgtgttg gggggcagaa 120 gatggaagcc cttggcaagc tcgatcgaac caagctacta aattgctgag ctcgttttaa 180 ctgaagtgtg agaaggaggt ttaaggcaag tagacaacat cctgttgttg gggtgcttct 240 ctcttttttg cacatctggc tgaactggga gtcaggtggt tgacttgtgc ctggctgcag 300 tagcagcggc atctcccttg cacagttctc ctcctcggcc tgcccaagag tccaccaggc 360 catggacgca gtggctgtgt atcatggcaa aatcagcagg gaaaccggcg agaagctcct 420 gcttgccact gggctggatg gcagctattt gctgagggac agcgagagcg tgccaggcgt 480 gtactgccta tgtgtgctgt atcacggtta catttataca taccgagtgt cccagacaga 540 aacaggttct tggagtgctg agacagcacc tggggtacat aaaagatatt tccggaaaat 600 aaaaaatctc atttcagcat ttcagaagcc agatcaaggc attgtaatac ctctgcagta 660 tccagttgag aagaagtcct cagctagaag tacacaaggt actacaggga taagagaaga 720 tcctgatgtc tgcctgaaag ccccatgaag aaaaataaaa caccttgtac tttattttct 780 ataatttaaa tatatgctaa gtcttatata ttgtagataa tacagttcgg tgagctacaa 840 atgcatttct aaagccattg tagtcctgta atggaagcat ctagcatgtc gtcaaagctg 900 aaatggactt ttgtacatag tgaggagctt tgaaacgagg attgggaaaa agtaattccg 960 taggttattt tcagttatta tatttacaaa tgggaaacaa aaggataatg aatactttat 1020 aaaggattaa tgtcaattct tgccaaatat aaataaaaat aatcctcagt ttttgtgaaa 1080 agctccattt ttagtgaaat attattttat agctactaat tttaaaatgt cttgcttgat 1140 tgtatggtgg gaagttggct ggtgtccctt gtctttgcca agttctccac tagctatggt 1200 gtcataggct cttttgggat ttttgaagct gtatactgtg tgctaaaaca agcactaaac 1260 aaagagtgaa ggatttatgt ttaattctga aagcaacctt cttgcctagt gttctgatat 1320 tggacagtaa aatccacaga ccaacctgga gttgaaaatc ttataattta aaatatgctc 1380 taaacatgtt tatcgtattt gatgctacag gatttgaaat tgtattacaa atccaatgaa 1440 atgagttttt cttttcattt acctctgccc cagttgtttc tactacatgg aagacctcat 1500 tttgaaggga aatttcagca gctgcagctc atgagtaact gatttgtaac aagcctcctt 1560 ttaaagtaac cctacaaaac cactggaaag tttatggttg tattattttt taaaaaaatt 1620 ccaagtgatt gaaacctaca cgagatacag aattttatgc ggcattttct tctcacattt 1680 atatttttgt gattttgtga ttgattatat gtcactttgc tacagggctc acagaattca 1740 ttcactcaac aaacataata gggcgctgag ggcatagaag taaaaacacc tggtccctgc 1800 tctcagttca ctgtcttgtt ggacgagaaa acaataacga taaaagacag tgaaagaaaa 1860 taacgataaa agacagtgaa agaaaataac aataaaagac aaggaaaaaa taacaatgaa 1920 agttgataag tacatgataa gcgaggttcc ccgtgtgtag gtagatctgg tctttagagg 1980 cagatagata ggtcagtgca aatactctgg tccatgggcc atatgaaaag gctaagcttc 2040 actgtaaaat aataactggg aattctggat tgtgtatggg tgttggtgaa cttggtttta 2100 attagtgaac tgctgagaga cagagctatt ctccatgtac tggcaagacc tgatttctga 2160 gcatttaata tggatgccgt gggagtacaa aagtggagtg tggcctgagt aatgcattat 2220 gggtggttta ccatttcttg aggtaaaagc atcacatgaa cttgtaaagg aatttaaaaa 2280 tcctactttc ataataagtt gcataggttt aataattttt aattatatgg cttgagttta 2340 aattgtaata ggcgtaacta attttaactc tataatgtgt tcattctgga ataatcctaa 2400 acatatgaat tatgtttgca tgttcacttc caagagcctt tttttgaaaa aaagcttttt 2460 ttgaatcatc aagtctttca catttaaata aagtgtttga aagctttatt tacctaaaaa 2520 aaa 2523 <210> 97 <211> 2669 <212> DNA <213> Homo sapiens lipase A, lysosomal acid, cholesterol esterase (LIPA) <400> 97 ttcccggtgg ctggctgctc tgattggctg aacaaatagt ccgagggtgg tgggcatccg 60 ccctcccgac aaggcagacc aggccccctg caggtcccct atccgcaccc cggcccctga 120 gagctggcac tgcgactcga gacagcggcc cggcaggaca gctccaggtg agagtgccgg 180 cgccgcggcg ctgccagaat gaaaatgcgg ttcttggggt tggtggtctg tttggttctc 240 tggaccctgc attctgaggg gtctggaggg aaactgacag ctgtggatcc tgaaacaaac 300 atgaatgtga gtgaaattat ctcttactgg ggattcccta gtgaggaata cctagttgag 360 acagaagatg gatatattct gtgccttaac cgaattcctc atgggaggaa gaaccattct 420 gacaaaggtc ccaaaccagt tgtcttcctg caacatggct tgctggcaga ttctagtaac 480 tgggtcacaa accttgccaa cagcagcctg ggcttcattc ttgctgatgc tggttttgac 540 gtgtggatgg gcaacagcag aggaaatacc tggtctcgga aacataagac actctcagtt 600 tctcaggatg aattctgggc tttcagttat gatgagatgg caaaatatga cctaccagct 660 tccattaact tcattctgaa taaaactggc caagaacaag tgtattatgt gggtcattct 720 caaggcacca ctataggttt tatagcattt tcacagatcc ctgagctggc taaaaggatt 780 aaaatgtttt ttgccctggg tcctgtggct tccgtcgcct tctgtactag ccctatggcc 840 aaattaggac gattaccaga tcatctcatt aaggacttat ttggagacaa agaatttctt 900 ccccagagtg cgtttttgaa gtggctgggt acccacgttt gcactcatgt catactgaag 960 gagctctgtg gaaatctctg ttttcttctg tgtggattta atgagagaaa tttaaatatg 1020 tctagagtgg atgtatatac aacacattct cctgctggaa cttctgtgca aaacatgtta 1080 cactggagcc aggctgttaa attccaaaag tttcaagcct ttgactgggg aagcagtgcc 1140 aagaattatt ttcattacaa ccagagttat cctcccacat acaatgtgaa ggacatgctt 1200 gtgccgactg cagtctggag cgggggtcac gactggcttg cagatgtcta cgacgtcaat 1260 atcttactga ctcagatcac caacttggtg ttccatgaga gcattccgga atgggagcat 1320 cttgacttca tttggggcct ggatgcccct tggaggcttt ataataaaat tattaatcta 1380 atgaggaaat atcagtgaaa gctggacttg agctgtgtac caccaagtca atgattatgt 1440 catgtgaaaa tgtgtttgct tcatttctgt aaaacacttg tttttctttc ccaggtcttt 1500 tgttttttta tatccaagaa aatgataact ttgaagatgc ccagttcact ctagtttcaa 1560 ttagaaacat actagctatt ttttctttaa ttagggctgg aataggaagc cagtgtctca 1620 accatagtat tgtctcttta agtcttttaa atatcactga tgtgtaaaaa ggtcattata 1680 tccattctgt ttttaaaatt taaaatatat tgactttttg cccttcatag gacaaagtaa 1740 tatatgtgtt ggaattttaa aattgtgttg tcattggtaa atctgtcact gacttaagcg 1800 aggtataaaa gtacgcagtt ttcatgtcct tgccttaaag agctctctag tctaacggtc 1860 ttgtagttag agatctaaat gacattttat catgttttcc tgcagcaggt gcatagtcaa 1920 atccagaaat atcacagctg tgccagtaat aaggatgcta acaattaatt ttatcaaacc 1980 taactgtgac agctgtgatt tgacacgttt taattgctca ggttaaatga aatagttttc 2040 cggcgtcttc aaaaacaaat tgcactgata aaacaaaaac aaaagtatgt tttaaatgct 2100 ttgaagactg atacactcaa ccatctatat tcatgagctc tcaatttcat ggcaggccat 2160 agttctactt atctgagaag caaatccctg tggagactat accactattt tttctgagat 2220 taatgtactc ttggagcccg ctactgtcgt tattgatcac atctgtgtga agccaaagcc 2280 ccgtggttgc ccatgagaag tgtccttgtt cattttcacc caaatgaagt gtgaacgtga 2340 tgttttcgga tgcaaactca gctcagggat tcattttgtg tcttagtttt atatgcatcc 2400 ttatttttaa tacacctgct tcacgtccct atgttgggaa gtccatattt gtctgctttt 2460 cttgcagcat catttcctta caatactgtc cggtggacaa aatgacaatt gatatgtttt 2520 tctgatataa ttactttagc tgcactaaca gtacaatgct tgttaatggt taatataggc 2580 agggcgaata ctactttgta acttttaaag tcttaaactt ttcaataaaa ttgagtgaga 2640 cttataggcc caaagaaaaa aaaaaaaaa 2669 <210> 98 <211> 1663 <212> DNA <213> Homo sapiens acid phosphatase 5, tartrate resistant (ACP5) <400> 98 cgccggggct cacctgggtc agccctgagc cctcgagcag ggcggatcgg ccgctgcctg 60 cttaaagctg gggccgccag gagtgcgatc gcctgcggat ctgcagctgg gcaccggccg 120 caacgcccgc cccgcgacgg cagggactga agggactcct gaatgtccgc gggacgtgtc 180 gcggcggcgc ccagcacgga ggaggcaggc agggagggaa taaaggctca gggaccggca 240 gttctactct agagcccacc agcctctcag agcctccggt gactggcctg tgtctccccc 300 tggatggaca tgtggacggc gctgctcatc ctgcaagcct tgttgctacc ctccctggct 360 gatggtgcca cccctgccct gcgctttgta gccgtgggtg actggggagg ggtccccaat 420 gccccattcc acacggcccg ggaaatggcc aatgccaagg agatcgctcg gactgtgcag 480 atcctgggtg cagacttcat cctgtctcta ggggacaatt tttacttcac tggtgtgcaa 540 gacatcaatg acaagaggtt ccaggagacc tttgaggacg tattctctga ccgctccctt 600 cgcaaagtgc cctggtacgt gctagccgga aaccatgacc accttggcaa tgtctctgcc 660 cagattgcat actctaagat ctccaagcgc tggaacttcc ccagcccttt ctaccgcctg 720 cacttcaaga tcccacagac caatgtgtct gtggccattt ttatgctgga cacagtgaca 780 ctatgtggca actcagatga cttcctcagc cagcagcctg agaggccccg agacgtgaag 840 ctggcccgca cacagctgtc ctggctcaag aaacagctgg cggcggccag ggaggactac 900 gtgctggtgg ctggccacta ccccgtgtgg tccatagccg agcacgggcc tacccactgc 960 ctggtcaagc agctacggcc actgctggcc acatacgggg tcactgccta cctgtgcggc 1020 cacgatcaca atctgcagta cctgcaagat gagaatggcg tgggctacgt gctgagtggg 1080 gctgggaatt tcatggaccc ctcaaagcgg caccagcgca aggtccccaa cggctatctg 1140 cgcttccact atgggactga agactcactg ggtggctttg cctatgtgga gatcagctcc 1200 aaagagatga ctgtcactta catcgaggcc tcgggcaagt ccctctttaa gaccaggctg 1260 ccgaggcgag ccaggccctg aactcccatg actgcccagc tctgaggccc gatctccact 1320 gttgggtggg tgggccctgc cgggaccctg ctcacaggca ggcttttcct ccaacctgtg 1380 gcgctgcagc agggcaggaa ggggaaacac agctgatgaa ctgtggtgcc acatgaccct 1440 tgtggcacag atgcccacgt atgtgaaaca cacatggaca tgtgtcccag ccacagtgtt 1500 atgctctgtg gctggctcac ctttgctgag ttccggggtg caatggggga gggagggagg 1560 gaaagcttcc tcctaaatca agcatctttc tgttactgat gttcaataaa agaatagttg 1620 ccaaggctga aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa 1663 <210> 99 <211> 4107 <212> DNA <213> Homo sapiens cathepsin S (CTSS) <400> 99 gacaagggct cttcttgatg gcttactgta tccactttgt ccccaagacc atagggaaat 60 gactagaggt gactgtacta gctagatttt aaatgaaact gaaatgaaag ttcacttcct 120 cattttgagt acctcatgtg acaagttcca atttcttttc aagtcaattg aactgaaatc 180 tccttgttgc tttgaaatct tagaagagag cccactaatt caaggactct tactgtggga 240 gcaactgctg gttctatcac aatgaaacgg ctggtttgtg tgctcttggt gtgctcctct 300 gcagtggcac agttgcataa agatcctacc ctggatcacc actggcatct ctggaagaaa 360 acctatggca aacaatacaa ggaaaagaat gaagaagcag tacgacgtct catctgggaa 420 aagaatctaa agtttgtgat gcttcacaac ctggagcatt caatgggaat gcactcatac 480 gatctgggca tgaaccacct gggagacatg accagtgaag aagtgatgtc tttgatgagt 540 tccctgagag ttcccagcca gtggcagaga aatatcacat ataagtcaaa ccctaatcgg 600 atattgcctg attctgtgga ctggagagag aaagggtgtg ttactgaagt gaaatatcaa 660 ggttcttgtg gtgcttgctg ggctttcagt gctgtggggg ccctggaagc acagctgaag 720 ctgaaaacag gaaagctggt gtctctcagt gcccagaacc tggtggattg ctcaactgaa 780 aaatatggaa acaaaggctg caatggtggc ttcatgacaa cggctttcca gtacatcatt 840 gataacaagg gcatcgactc agacgcttcc tatccctaca aagccatgga tcagaaatgt 900 caatatgact caaaatatcg tgctgccaca tgttcaaagt acactgaact tccttatggc 960 agagaagatg tcctgaaaga agctgtggcc aataaaggcc cagtgtctgt tggtgtagat 1020 gcgcgtcatc cttctttctt cctctacaga agtggtgtct actatgaacc atcctgtact 1080 cagaatgtga atcatggtgt acttgtggtt ggctatggtg atcttaatgg gaaagaatac 1140 tggcttgtga aaaacagctg gggccacaac tttggtgaag aaggatatat tcggatggca 1200 agaaataaag gaaatcattg tgggattgct agctttccct cttacccaga aatctagagg 1260 atctctcctt tttataacaa atcaagaaat atgaagcact ttctcttaac ttaatttttc 1320 ctgctgtatc cagaagaaat aattgtgtca tgattaatgt gtatttactg tactaattag 1380 aaaatatagt ttgaggccgg gcacggtggc tcacgcctgt aatcccagta cttgggaggc 1440 caaggcaggc atatcaactt gaggccagga gttaaagagc agcctggcta acatggtgaa 1500 accccatctc tactaaaaat acaaaaaatt agccgagcac ggtggtgcat gcctgtaatc 1560 ccagctactt gggaggctga ggcacgagat tccttgaacc caagaggttg aggctatgtt 1620 gagctgagat cacaccactg tactccagcc tggatgacag agtggagact ctgtttcaaa 1680 aaaacagaaa agaaaatata gtttgattct tcattttttt aaatttgcaa atctcaggat 1740 aaagtttgct aagtaaatta gtaatgtact atagatataa ctgtacaaaa attgttcaac 1800 ctaaaacaat ctgtaattgc ttattgtttt attgtatact ctttgtcttt ttaagacccc 1860 taatagcctt ttgtaacttg atggcttaaa aatacttaat aaatctgcca tttcaaattt 1920 ctatcattgc cacataccat tcttattcct aggcaactat taataatcta tcctgagaat 1980 attaattgtg gtattctggt gatggggttt agcaactttg atggaagaaa atattaggct 2040 ataaatgtcc taaggactca gattgtatct ttgtacagaa gaggattcaa aacgccacgt 2100 gtagtggctc atgcctgtaa tcccaacact ttgggaggct gaagtaggag gatcgtcttg 2160 agcccaggag ttcaagacca gcctggacaa catagtgaga ccttgtctcc acaaaaataa 2220 aaaagaaact atccaggagt ggtggtgtgt gcctgtggtc cctgctatgc agatgtctaa 2280 gacaggagga tcacaagagc ccaggaggtt gagaatgcag tgagcttgta attgcaccac 2340 tgcactccag cctgggtgac agagcaagac cctgtcttaa aaaaagagga ttcaacacat 2400 atttttatat tatgttaaag taaagaaatg cataaaagac aagcactttg gaagaattat 2460 tttaatgatc aacaatttaa tgtattagtc caaattattt ttacgtagtc atcaacaatt 2520 tgaccagggc ctttatttgg caaataactg agccaaccag aataaaataa ccaatactcc 2580 actgctcata tttttatcta attcagatgg atcttcctta caactgctct agattagtag 2640 atgcatctaa gcaggcagca ggaactttaa attttttaag ttcatgtcta tgacatgaac 2700 aatgtgtggg ataatgtcat taatatatcc taaattaacc taaacgtatt tcactaactc 2760 tggctccttc tccataaagc acattttaag gaacaagaat tgctaaatat aaaaacataa 2820 ataataccat aatacatggc tatcatcaaa agtgtataga atattatagt ttaaaagtat 2880 ttagttgatt acttttcagt tttgttttgt tttttgagac ggagtctcac tctgttgccc 2940 aggctggagt gcagtggcac catctcagtt cactgcaact tctgcctccc gagttcaagc 3000 gattctcctg cctcagcctc ccgagtagct ggaattatag gcgtgcacca ccacgcccag 3060 ctaatttttg tatttttagt aaagacaggg ttttgccaca ttagccaggc tggtctcaaa 3120 ctcctgacct caggtgatcc acccacccca gcctcccaaa gtgctaagat tacaggcgtg 3180 agccactgag cccagcctac ttttcagttt ttaacataat ttttgtttta tccacaactt 3240 ttcaagtatt gaaagtagaa taaaaacatg ggttcttagt ctttagctat ctgttaaagc 3300 ctatgaatgc cttcttaaaa tcatgttttt aaatgcataa aatatatagg attacaaagg 3360 aatctaatta tatcgaaata cagttattaa aatgttaaaa gataagtttg ttatatatta 3420 atatgcatgc ttctttataa atgcattaaa taagagttaa tagctatcct aaatttgaaa 3480 tagtgataag cataatgaaa atagatgcaa aaaactaatg tgatatgaaa atatctgggt 3540 ttttcttttg atgatgaagt attgctaata ttaccgtggt ttatgaacta tgttcagaat 3600 tgaagaaaat cctaactttc agttagaggt tagtgacggg gttcaggaca ccctacacaa 3660 aatacagcac tttgacatat tgaatatttt aagctgaagg catttgagga aattgcagaa 3720 gcaggaaggt gactctgacc ttctgcctgc tgttctcccc agaagcagcc ataaaacctg 3780 ggaaggattt tctgaccttc ccctgaagta gatcataaga ctgtcatgta agaggtgctc 3840 tcctggcacc cagagaaaag gagcatcctt acctccaaaa gcacagggac acaaagagga 3900 atctaaacaa acaggcctct cagtttcccc cagtttatta catttagctt gttcacactt 3960 tgccctatga catttctaca tcactggctg ctcttcatca aacctactat aaaaaacatt 4020 caagttcaac tgtttctttg ggcctttatt tccttatgga gcccctcgtg tcgtgtaaaa 4080 cttatattaa ataaatgtgc atgcttt 4107 <210> 100 <211> 1311 <212> DNA <213> Homo sapiens CD3g molecule, gamma (CD3-TCR complex) (CD3G) <400> 100 agtctagctg ctgcacaggc tggctggctg gctggctgct aagggctgct ccacgctttt 60 gccggaggac agagactgac atggaacagg ggaagggcct ggctgtcctc atcctggcta 120 tcattcttct tcaaggtact ttggcccagt caatcaaagg aaaccacttg gttaaggtgt 180 atgactatca agaagatggt tcggtacttc tgacttgtga tgcagaagcc aaaaatatca 240 catggtttaa agatgggaag atgatcggct tcctaactga agataaaaaa aaatggaatc 300 tgggaagtaa tgccaaggac cctcgaggga tgtatcagtg taaaggatca cagaacaagt 360 caaaaccact ccaagtgtat tacagaatgt gtcagaactg cattgaacta aatgcagcca 420 ccatatctgg ctttctcttt gctgaaatcg tcagcatttt cgtccttgct gttggggtct 480 acttcattgc tggacaggat ggagttcgcc agtcgagagc ttcagacaag cagactctgt 540 tgcccaatga ccagctctac cagcccctca aggatcgaga agatgaccag tacagccacc 600 ttcaaggaaa ccagttgagg aggaattgaa ctcaggactc agagtagtcc aggtgttctc 660 ctcctattca gttcccagaa tcaaagcaat gcattttgga aagctcctag cagagagact 720 ttcagcccta aatctagact caaggttccc agagatgaca aatggagaag aaaggccatc 780 agagcaaatt tgggggtttc tcaaataaaa taaaaataaa aacaaatact gtgtttcaga 840 agcgccacct attggggaaa attgtaaaag aaaaatgaaa agatcaaata accccctgga 900 tttgaatata attttttgtg ttgtaatttt tatttcgttt ttgtataggt tataattcac 960 atggctcaaa tattcagtga aagctctccc tccaccgcca tcccctgcta cccagtgacc 1020 ctgttgccct cttcagagac aaattagttt ctcttttttt tttttttttt tttttttttg 1080 agacagtctg gctctgtcac ccaggctgaa atgcagtggc accatctcgg ctcactgcaa 1140 cctctgcctc ctgggttcaa gcgattctcc tgcctcagcc tcccgggcag ctgggattac 1200 aggcacacac taccacacct ggctaatttt tgtattttta gtagagacag ggttttgctc 1260 tgttggccaa gctggtctcg aactcctgac ctcaagtgat ccgcccgcct c 1311

Claims (22)

  1. 서열번호: 1 내지 50의 염기서열로 이루어진 유전자 및 서열번호: 51 내지 100의 염기서열로 이루어진 유전자의 mRNA 또는 이들의 유전자에 의해 코딩되는 단백질의 발현수준을 측정하는 제제를 포함하는, 유방암의 예후 예측용 조성물.
  2. 제1항에 있어서, 서열번호: 1 내지 50의 염기서열로 이루어진 유전자들이 정상 대조군에 비해 유방암 재발군에서 차등적으로 발현이 증가된 유전자들인 것인, 유방암의 예후 예측용 조성물.
  3. 제1항에 있어서, 서열번호: 51 내지 100의 염기서열로 이루어진 유전자들이 정상 대조군에 비해 유방암 비재발군에서 차등적으로 발현이 증가된 유전자들인 것인, 유방암의 예후 예측용 조성물.
  4. 제1항에 있어서, mRNA의 발현수준을 측정하는 제제가 상기 유전자에 특이적으로 결합하는 안티센스 올리고뉴클레오티드, 프라이머 쌍 또는 프로브인 것인, 유방암의 예후 예측용 조성물.
  5. 제1항에 있어서, 단백질의 발현수준을 측정하는 제제가 상기 유전자로부터 코딩되는 단백질에 특이적인 항체인 것인, 유방암의 예후 예측용 조성물.
  6. 제1항에 있어서, 상기 조성물이 유방암 치료 후 2년 이내에 유방암이 재발할 가능성을 예측하기 위한 것인, 유방암의 예후 예측용 조성물.
  7. 제1항 내지 제6항 중 어느 한 항의 조성물을 포함하는, 유방암의 예후 예측용 키트.
  8. 제7항에 있어서, 상기 키트가 RT-PCR 키트, 마이크로어레이 칩 키트 또는 단백질 칩 키트인 것인, 유방암의 예후 예측용 키트.
  9. 제8항에 있어서, 상기 RT-PCR 키트가 서열번호: 1 내지 50의 염기서열로 이루어진 유전자 및 서열번호: 51 내지 100의 염기서열로 이루어진 유전자에 특이적인 프라이머 쌍을 포함하는 것인, 유방암의 예후 예측용 키트.
  10. 제8항에 있어서, 상기 마이크로어레이 칩 키트가 서열번호: 1 내지 50의 염기서열로 이루어진 유전자 및 서열번호: 51 내지 100의 염기서열로 이루어진 유전자에 특이적인 프로브를 포함하는 것인, 유방암의 예후 예측용 키트.
  11. 제8항에 있어서, 상기 단백질 칩 키트가 서열번호: 1 내지 50의 염기서열로 이루어진 유전자 및 서열번호: 51 내지 100의 염기서열로 이루어진 유전자로부터 코딩되는 단백질에 특이적인 항체를 포함하는 것인, 유방암의 예후 예측용 키트.
  12. 1) 분리된 개체의 시료로부터 서열번호: 1 내지 50의 염기서열로 이루어진 유전자의 mRNA 발현수준 또는 상기 유전자에 의해 코딩되는 단백질의 발현수준을 측정하는 단계;
    2) 상기 유전자의 mRNA 발현수준 또는 단백질의 발현수준을 정상 대조군 시료의 발현수준과 비교하는 단계;
    3) 정상 대조군 시료보다 증가된 발현수준을 나타내는 개체의 시료로부터 서열번호: 51 내지 100의 염기서열로 이루어진 유전자의 mRNA 발현수준 또는 상기 유전자에 의해 코딩되는 단백질의 발현수준을 측정하는 단계;
    4) 상기 유전자의 mRNA 발현수준 또는 단백질의 발현수준을 정상 대조군 시료의 발현수준과 비교하는 단계; 및
    5) 정상 대조군 시료보다 감소된 발현수준을 나타내는 개체의 시료를 정상 대조군 시료보다 유방암의 재발 가능성이 높은 것으로 판정하는 단계를 포함하는, 유방암의 예후를 예측하는데 필요한 정보를 제공하는 방법.
  13. 제12항에 있어서, 상기 방법에서 단계 1) 내지 단계 4)를 순서대로 수행하거나, 단계 1) 및 3)을 동시에 수행한 후 이어서 단계 2) 및 4)를 동시에 수행하는 것인 방법.
  14. 제12항에 있어서, 상기 단계 2)에서 mRNA의 발현수준을 측정하는 제제가 상기 유전자에 특이적으로 결합하는 안티센스 올리고뉴클레오티드, 프라이머 쌍 또는 프로브인 것인 방법.
  15. 제12항에 있어서, 상기 단계 2)에서 mRNA 발현수준이 역전사효소 중합효소반응, 경쟁적 역전사효소 중합효소반응, 실시간 역전사효소 중합효소반응, RNase 보호 분석법, 노던 블랏팅 및 DNA 마이크로어레이 칩으로 구성된 군으로부터 선택되는 분석법에 의해 측정되는 것인 방법.
  16. 제12항에 있어서, 상기 단계 4)에서 단백질의 발현수준을 측정하는 제제가 상기 유전자로부터 코딩되는 단백질에 특이적인 항체인 것인 방법.
  17. 제12항에 있어서, 상기 단계 4)에서 단백질 발현수준이 웨스턴 블랏팅, ELISA, 방사선면역분석법, 방사면역확산법, 오우크레로니(Ouchterlony) 면역확산법, 로케트 면역전기영동, 면역조직화학염색, 면역침전분석, 보체고정분석, FACS 및 단백질 칩으로 구성된 군으로부터 선택되는 분석법에 의해 측정되는 것인 방법.
  18. 1) 서열번호: 1 내지 50의 염기서열로 이루어진 유전자의 발현이 증가하고 서열번호: 51 내지 100의 염기서열로 이루어진 유전자의 발현이 감소된 세포와 시험물질을 접촉시키는 단계;
    2) 상기 유전자의 mRNA 발현수준 또는 상기 유전자로부터 코딩되는 단백질의 발현수준을 측정하는 단계; 및
    3) 시험물질 처리 세포의 발현수준을 미처리 세포의 발현수준과 비교하여 서열번호: 1 내지 50의 염기서열로 이루어진 유전자의 발현은 억제하면서 서열번호: 51 내지 100의 염기서열로 이루어진 유전자의 발현을 활성화시키는 시험물질을 스크리닝하는 단계를 포함하는, 유방암의 재발 억제제를 스크리닝하는 방법.
  19. 제18항에 있어서, 상기 단계 2)에서 mRNA의 발현수준을 측정하는 제제가 상기 유전자에 특이적으로 결합하는 안티센스 올리고뉴클레오티드, 프라이머 쌍 또는 프로브인 것인 방법.
  20. 제18에 있어서, 상기 단계 2)에서 mRNA 발현수준이 역전사효소 중합효소반응, 경쟁적 역전사효소 중합효소반응, 실시간 역전사효소 중합효소반응, RNase 보호 분석법, 노던 블랏팅 및 DNA 마이크로어레이 칩으로 구성된 군으로부터 선택되는 분석법에 의해 측정되는 것인 방법.
  21. 제18항에 있어서, 상기 단계 2)에서 단백질의 발현수준을 측정하는 제제가 상기 유전자로부터 코딩되는 단백질에 특이적인 항체인 것인 방법.
  22. 제18항에 있어서, 상기 단계 4)에서 단백질 발현수준이 웨스턴 블랏팅, ELISA, 방사선면역분석법, 방사면역확산법, 오우크레로니(Ouchterlony) 면역확산법, 로케트 면역전기영동, 면역조직화학염색, 면역침전분석, 보체고정분석, FACS 및 단백질 칩으로 구성된 군으로부터 선택되는 분석법에 의해 측정되는 것인 방법.
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WO2018074865A3 (ko) * 2016-10-21 2018-08-09 서울대학교병원 유방암 예후 예측용 조성물 및 방법
WO2018155948A1 (ko) * 2017-02-24 2018-08-30 사회복지법인 삼성생명공익재단 폐암 환자의 생존 예후 예측용 마커
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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100035240A1 (en) * 2004-08-10 2010-02-11 Cardiff Biologicals Limited Methods and kit for the prognosis of breast cancer

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040018525A1 (en) * 2002-05-21 2004-01-29 Bayer Aktiengesellschaft Methods and compositions for the prediction, diagnosis, prognosis, prevention and treatment of malignant neoplasma
US7306910B2 (en) * 2003-04-24 2007-12-11 Veridex, Llc Breast cancer prognostics
JP2006526415A (ja) * 2003-05-30 2006-11-24 テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション 乳癌の診断、予後診断及び治療方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100035240A1 (en) * 2004-08-10 2010-02-11 Cardiff Biologicals Limited Methods and kit for the prognosis of breast cancer

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WO2018074865A3 (ko) * 2016-10-21 2018-08-09 서울대학교병원 유방암 예후 예측용 조성물 및 방법
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WO2018155948A1 (ko) * 2017-02-24 2018-08-30 사회복지법인 삼성생명공익재단 폐암 환자의 생존 예후 예측용 마커
KR20180098155A (ko) * 2017-02-24 2018-09-03 사회복지법인 삼성생명공익재단 폐암 환자의 생존 예후 예측용 마커
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