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JPS5746966A - Pyridazinone derivative and its production - Google Patents

Pyridazinone derivative and its production

Info

Publication number
JPS5746966A
JPS5746966A JP12101980A JP12101980A JPS5746966A JP S5746966 A JPS5746966 A JP S5746966A JP 12101980 A JP12101980 A JP 12101980A JP 12101980 A JP12101980 A JP 12101980A JP S5746966 A JPS5746966 A JP S5746966A
Authority
JP
Japan
Prior art keywords
formula
compound
pyridazinone
solvent
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP12101980A
Other languages
Japanese (ja)
Other versions
JPS6326755B2 (en
Inventor
Isao Kataue
Keisuke Yagami
Nobuyuki Fukazawa
Makoto Odate
Hajime Iizuka
Takashi Nishina
Joji Kamiya
Yasuhito Tanaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsui Toatsu Chemicals Inc
Original Assignee
Mitsui Toatsu Chemicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsui Toatsu Chemicals Inc filed Critical Mitsui Toatsu Chemicals Inc
Priority to JP12101980A priority Critical patent/JPS5746966A/en
Publication of JPS5746966A publication Critical patent/JPS5746966A/en
Publication of JPS6326755B2 publication Critical patent/JPS6326755B2/ja
Granted legal-status Critical Current

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  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:Pyridazinone derivatives of formula I (R1, R2 are H, or incorporate to form a single bond; R3, R4 are H, lower alkyl; A is phenyl, pyridyl, furyl, thienyl, substituted phenyl).
EXAMPLE: 6-( 4-Benzylideneaminophenyl )-5-methyl-4,5-dihydro-3( 2H )-pyridazinone.
USE: They are used as a medicine such as hypotensor, antithrombotic or anti-inflammatory or as a synthetic intermediate of such medicines.
PREPARATION: The reaction between a compound of formula II or its reactive derivative such as benzaldehyde, acetophenone or acetal and another compound of formula III is conducted in no solvent or a solvent such as benzene in the absence or presence of a catalyst such as benzenesulfonic acid at room temperature W200°C to give the compound of formula I.
COPYRIGHT: (C)1982,JPO&Japio
JP12101980A 1980-09-03 1980-09-03 Pyridazinone derivative and its production Granted JPS5746966A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP12101980A JPS5746966A (en) 1980-09-03 1980-09-03 Pyridazinone derivative and its production

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12101980A JPS5746966A (en) 1980-09-03 1980-09-03 Pyridazinone derivative and its production

Publications (2)

Publication Number Publication Date
JPS5746966A true JPS5746966A (en) 1982-03-17
JPS6326755B2 JPS6326755B2 (en) 1988-05-31

Family

ID=14800786

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12101980A Granted JPS5746966A (en) 1980-09-03 1980-09-03 Pyridazinone derivative and its production

Country Status (1)

Country Link
JP (1) JPS5746966A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4521415A (en) * 1981-12-28 1985-06-04 Mitsui Toatsu Kagaku Kabushiki Kaisha 6-(Substituted phenyl)-4,5-dihydro-3(2H)-pyridazinone compounds
US4639451A (en) * 1981-10-20 1987-01-27 Mitsui Toatsu Kagaku-Kabushiki Kaisha Pyridazinone derivatives
US5110925A (en) * 1988-02-13 1992-05-05 Nippon Soda Co., Ltd. Pyridazinone derivatives
US5151420A (en) * 1988-10-19 1992-09-29 Orion Corporation/Orion Pharmaceutica Substituted pyridazinones
US8207168B2 (en) 2006-07-25 2012-06-26 Cephalon, Inc. Pyridazinone derivatives

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6382050U (en) * 1986-11-19 1988-05-30

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4639451A (en) * 1981-10-20 1987-01-27 Mitsui Toatsu Kagaku-Kabushiki Kaisha Pyridazinone derivatives
US4521415A (en) * 1981-12-28 1985-06-04 Mitsui Toatsu Kagaku Kabushiki Kaisha 6-(Substituted phenyl)-4,5-dihydro-3(2H)-pyridazinone compounds
US5110925A (en) * 1988-02-13 1992-05-05 Nippon Soda Co., Ltd. Pyridazinone derivatives
US5151420A (en) * 1988-10-19 1992-09-29 Orion Corporation/Orion Pharmaceutica Substituted pyridazinones
US8207168B2 (en) 2006-07-25 2012-06-26 Cephalon, Inc. Pyridazinone derivatives
US8247414B2 (en) 2006-07-25 2012-08-21 Cephalon, Inc. Pyridizinone derivatives and the use thereof as H3 inhibitors
US8586588B2 (en) 2006-07-25 2013-11-19 Cephalon, Inc. Aryl pyridazinone derivatives and their use as H3 receptor ligands
US8673916B2 (en) 2006-07-25 2014-03-18 Cephalon, Inc. Methods of treating disorders mediated by histamine H3 receptors using pyridazinone derivatives

Also Published As

Publication number Publication date
JPS6326755B2 (en) 1988-05-31

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