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JPS5671084A - 5,8,11,14,17-eicosapentaenoic acid alpha-tocopherol ester and its preparation - Google Patents

5,8,11,14,17-eicosapentaenoic acid alpha-tocopherol ester and its preparation

Info

Publication number
JPS5671084A
JPS5671084A JP14774179A JP14774179A JPS5671084A JP S5671084 A JPS5671084 A JP S5671084A JP 14774179 A JP14774179 A JP 14774179A JP 14774179 A JP14774179 A JP 14774179A JP S5671084 A JPS5671084 A JP S5671084A
Authority
JP
Japan
Prior art keywords
eicosapentaenoic acid
preparation
tocopherol ester
acid
tocopherol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP14774179A
Other languages
Japanese (ja)
Other versions
JPS6332071B2 (en
Inventor
Mitsuo Mazaki
Takayuki Hara
Masatoshi Hayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Chemiphar Co Ltd
Original Assignee
Nippon Chemiphar Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Chemiphar Co Ltd filed Critical Nippon Chemiphar Co Ltd
Priority to JP14774179A priority Critical patent/JPS5671084A/en
Publication of JPS5671084A publication Critical patent/JPS5671084A/en
Publication of JPS6332071B2 publication Critical patent/JPS6332071B2/ja
Granted legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

NEW MATERIAL:5,8,11,14,17-Eicosapentaenoic acid α-tocopherol ester.
USE: Blood platelet coagulation inhibitor: it is more stable and absorbable than 5,8, 11,14,17-eicosapentaenoic acid.
PREPARATION: 5,8,11,14,17-Eicosapentaenoic acid or its reactive derivative such as its acid halide or acid anhydride and α-tocopherol are made to react in an inert solvent such as water or dichloromethane at room temperature to refluxing one of the solvent for 1W20hr to give 5,8,11,14,17-eicosapentaenoic acid α-tocopherol ester. When 5,8,11,14,17-eicosapentaenoic acid is used directly, the reaction preferably is effected in the presence of N,N-dicyclohexylcarbodiimide or 2-substituted pyridinium salt and a base.
COPYRIGHT: (C)1981,JPO&Japio
JP14774179A 1979-11-16 1979-11-16 5,8,11,14,17-eicosapentaenoic acid alpha-tocopherol ester and its preparation Granted JPS5671084A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP14774179A JPS5671084A (en) 1979-11-16 1979-11-16 5,8,11,14,17-eicosapentaenoic acid alpha-tocopherol ester and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14774179A JPS5671084A (en) 1979-11-16 1979-11-16 5,8,11,14,17-eicosapentaenoic acid alpha-tocopherol ester and its preparation

Publications (2)

Publication Number Publication Date
JPS5671084A true JPS5671084A (en) 1981-06-13
JPS6332071B2 JPS6332071B2 (en) 1988-06-28

Family

ID=15437087

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14774179A Granted JPS5671084A (en) 1979-11-16 1979-11-16 5,8,11,14,17-eicosapentaenoic acid alpha-tocopherol ester and its preparation

Country Status (1)

Country Link
JP (1) JPS5671084A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59222487A (en) * 1983-06-02 1984-12-14 Terumo Corp Unsaturated fatty acid derivative
FR2825088A1 (en) * 2001-05-25 2002-11-29 Derma Dev NOVEL TOCOPHEROL ESTERS, PROCESSES FOR OBTAINING SAME AND USES THEREOF

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59222487A (en) * 1983-06-02 1984-12-14 Terumo Corp Unsaturated fatty acid derivative
FR2825088A1 (en) * 2001-05-25 2002-11-29 Derma Dev NOVEL TOCOPHEROL ESTERS, PROCESSES FOR OBTAINING SAME AND USES THEREOF

Also Published As

Publication number Publication date
JPS6332071B2 (en) 1988-06-28

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