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JPS5649361A - Carbostyril derivative - Google Patents

Carbostyril derivative

Info

Publication number
JPS5649361A
JPS5649361A JP12556879A JP12556879A JPS5649361A JP S5649361 A JPS5649361 A JP S5649361A JP 12556879 A JP12556879 A JP 12556879A JP 12556879 A JP12556879 A JP 12556879A JP S5649361 A JPS5649361 A JP S5649361A
Authority
JP
Japan
Prior art keywords
formula
halogen
compound
derivative
carbostyril
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP12556879A
Other languages
Japanese (ja)
Other versions
JPS6320226B2 (en
Inventor
Kazuhisa Sakano
Takafumi Fujioka
Yasuo Oshiro
Kazuyuki Nakagawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP12556879A priority Critical patent/JPS5649361A/en
Publication of JPS5649361A publication Critical patent/JPS5649361A/en
Publication of JPS6320226B2 publication Critical patent/JPS6320226B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Quinoline Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A carbostyril derivative of formula I (R1 is H, lower alkyl, lower alkenyl or lower alkynyl; R2 is H or lower alkyl; R3 is naphthyl or group of formula II; R4 is nitro, amino, carboxy, lower alkoxycarbonyl, hydroxy, etc.; Y is lower alkylene; X is halogen; n is 0W2; the bond between the 3- and the 4-carbon atoms in the carbostyril skeleton is single or double bond) and its salt.
EXAMPLE: 5-[3-[ 4-( 2-Hydroxyphenyl )-1-piperazinyl ]propoxy]-3, 4-dihydrocarbostyril.
USE: Antihistaminic agent for the remedy of acute uriticaria, and a diagnotic agent for the determination of gastric juice secretion function. Also useful as a central nervous system depressant having transquillizing activity, etc.
PROCESS: The compound of formula I is prepared by reacting a compound of formula III (X1 is halogen) with a piperizine derivative of formula IV.
COPYRIGHT: (C)1981,JPO&Japio
JP12556879A 1979-09-28 1979-09-28 Carbostyril derivative Granted JPS5649361A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP12556879A JPS5649361A (en) 1979-09-28 1979-09-28 Carbostyril derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12556879A JPS5649361A (en) 1979-09-28 1979-09-28 Carbostyril derivative

Publications (2)

Publication Number Publication Date
JPS5649361A true JPS5649361A (en) 1981-05-02
JPS6320226B2 JPS6320226B2 (en) 1988-04-26

Family

ID=14913404

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12556879A Granted JPS5649361A (en) 1979-09-28 1979-09-28 Carbostyril derivative

Country Status (1)

Country Link
JP (1) JPS5649361A (en)

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62135423A (en) * 1985-12-09 1987-06-18 Otsuka Pharmaceut Co Ltd Improver for hypoxia
EP0226441A2 (en) * 1985-12-09 1987-06-24 Otsuka Pharmaceutical Co., Ltd. Preparation of pharmaceutical compositions for the treatment of hypoxia
JPS62209283A (en) * 1986-03-10 1987-09-14 Taiyo Tekko Kk Normal closed type solenoid valve
JPS63290821A (en) * 1987-05-25 1988-11-28 Otsuka Pharmaceut Co Ltd Antiarrhythmic
JPH02191256A (en) * 1988-10-31 1990-07-27 Otsuka Pharmaceut Co Ltd Carbostyryl derivative and remedy for schizophrenia containing the same
JPH04352723A (en) * 1991-05-31 1992-12-07 Otsuka Pharmaceut Co Ltd Akathisia therapeutic agent
JPH07165720A (en) * 1988-10-31 1995-06-27 Otsuka Pharmaceut Co Ltd Carbostyril derivative and therapeutic agent for schizophrenia containing the same derivative
JPH07252153A (en) * 1995-01-25 1995-10-03 Otsuka Pharmaceut Co Ltd Antiarrhythmic agent
JPH07304740A (en) * 1995-03-16 1995-11-21 Otsuka Pharmaceut Co Ltd Carbostyril derivative
JPH07304741A (en) * 1995-03-16 1995-11-21 Otsuka Pharmaceut Co Ltd Carbostyril derivative and therapeutic agent for schizophrenia containing the same derivative
US7160888B2 (en) 2003-08-22 2007-01-09 Warner Lambert Company Llc [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia
JP2010528042A (en) * 2007-05-21 2010-08-19 レビバ ファーマシューティカルズ，インコーポレーテッド Composition, synthesis and method of use of quinolinone atypical antipsychotic drugs
US7888362B2 (en) 2005-04-14 2011-02-15 Otsuka Pharmaceutical Co., Ltd. Piperazine-substituted benzothiophenes for treatment of mental disorders
JP2011520815A (en) * 2008-05-09 2011-07-21 エモリー・ユニバーシテイ NMDA receptor antagonist for the treatment of neuropsychiatric disorders
US8071600B2 (en) 2005-08-31 2011-12-06 Otsuka Pharmaceutical Co., Ltd. Derivatives of 4-piperazin-1-yl-4-benzo[B]thiophene suitable for the treatment of CNS disorders

Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62135423A (en) * 1985-12-09 1987-06-18 Otsuka Pharmaceut Co Ltd Improver for hypoxia
EP0226441A2 (en) * 1985-12-09 1987-06-24 Otsuka Pharmaceutical Co., Ltd. Preparation of pharmaceutical compositions for the treatment of hypoxia
US4914094A (en) * 1985-12-09 1990-04-03 Otsuka Pharmaceutical Co., Ltd. Method for treating hypoxia
EP0226441A3 (en) * 1985-12-09 1990-04-04 Otsuka Pharmaceutical Co., Ltd. Preparation of pharmaceutical compositions for the treatment of hypoxia
JPS62209283A (en) * 1986-03-10 1987-09-14 Taiyo Tekko Kk Normal closed type solenoid valve
JPH0368270B2 (en) * 1986-03-10 1991-10-25 Taiyo Tekko Kk
JPS63290821A (en) * 1987-05-25 1988-11-28 Otsuka Pharmaceut Co Ltd Antiarrhythmic
JPH02191256A (en) * 1988-10-31 1990-07-27 Otsuka Pharmaceut Co Ltd Carbostyryl derivative and remedy for schizophrenia containing the same
JPH07165720A (en) * 1988-10-31 1995-06-27 Otsuka Pharmaceut Co Ltd Carbostyril derivative and therapeutic agent for schizophrenia containing the same derivative
JPH04352723A (en) * 1991-05-31 1992-12-07 Otsuka Pharmaceut Co Ltd Akathisia therapeutic agent
JPH07252153A (en) * 1995-01-25 1995-10-03 Otsuka Pharmaceut Co Ltd Antiarrhythmic agent
JPH07304741A (en) * 1995-03-16 1995-11-21 Otsuka Pharmaceut Co Ltd Carbostyril derivative and therapeutic agent for schizophrenia containing the same derivative
JPH07304740A (en) * 1995-03-16 1995-11-21 Otsuka Pharmaceut Co Ltd Carbostyril derivative
JP2987484B2 (en) * 1995-03-16 1999-12-06 大塚製薬 株式会社 Method for producing carbostyril derivative
US7160888B2 (en) 2003-08-22 2007-01-09 Warner Lambert Company Llc [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia
US7888362B2 (en) 2005-04-14 2011-02-15 Otsuka Pharmaceutical Co., Ltd. Piperazine-substituted benzothiophenes for treatment of mental disorders
US8349840B2 (en) 2005-04-14 2013-01-08 Otsuka Pharmaceutical Co., Ltd. Piperazine-substituted benzothiophenes for treatment of mental disorders
US9480686B2 (en) 2005-04-14 2016-11-01 Otsuka Pharmaceutical Co., Ltd. Piperazine-substituted benzothiophenes for treatment of mental disorders
US9839637B1 (en) 2005-04-14 2017-12-12 Otsuka Pharmaceutical Co., Ltd. Piperazine-substituted benzothiophenes for treatment of mental disorders
USRE48059E1 (en) 2005-04-14 2020-06-23 Otsuka Pharmaceutical Co., Ltd. Piperazine-substituted benzothiophenes for treatment of mental disorders
US8071600B2 (en) 2005-08-31 2011-12-06 Otsuka Pharmaceutical Co., Ltd. Derivatives of 4-piperazin-1-yl-4-benzo[B]thiophene suitable for the treatment of CNS disorders
US8598162B2 (en) 2005-08-31 2013-12-03 Otsuka Pharmaceutical Co., Ltd. Derivatives of 4-piperazin-1-yl-4-benzo[B]thiophene suitable for the treatment of CNS disorders
JP2010528042A (en) * 2007-05-21 2010-08-19 レビバ ファーマシューティカルズ，インコーポレーテッド Composition, synthesis and method of use of quinolinone atypical antipsychotic drugs
JP2011520815A (en) * 2008-05-09 2011-07-21 エモリー・ユニバーシテイ NMDA receptor antagonist for the treatment of neuropsychiatric disorders

Also Published As

Publication number Publication date
JPS6320226B2 (en) 1988-04-26

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