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JPS55130912A - Antiphlogistic agent - Google Patents

Antiphlogistic agent

Info

Publication number
JPS55130912A
JPS55130912A JP3879379A JP3879379A JPS55130912A JP S55130912 A JPS55130912 A JP S55130912A JP 3879379 A JP3879379 A JP 3879379A JP 3879379 A JP3879379 A JP 3879379A JP S55130912 A JPS55130912 A JP S55130912A
Authority
JP
Japan
Prior art keywords
formula
compound
antiphlogistic
agnet
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP3879379A
Other languages
Japanese (ja)
Other versions
JPS6350325B2 (en
Inventor
Hajime Fujimura
Yasuzo Hiramatsu
Takahiro Yabuuchi
Masakatsu Kuki
Katsuo Takigawa
Takatsugu Honna
Hidekazu Miyake
Akira Kajitani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Institute for Production Development
Zaidan Hojin Seisan Kaihatsu Kenkyusho
Original Assignee
Research Institute for Production Development
Zaidan Hojin Seisan Kaihatsu Kenkyusho
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Institute for Production Development, Zaidan Hojin Seisan Kaihatsu Kenkyusho filed Critical Research Institute for Production Development
Priority to JP3879379A priority Critical patent/JPS55130912A/en
Priority to US06/134,411 priority patent/US4287207A/en
Priority to DE3012190A priority patent/DE3012190C2/en
Priority to FR8007036A priority patent/FR2452925A1/en
Priority to GB8010753A priority patent/GB2055043B/en
Publication of JPS55130912A publication Critical patent/JPS55130912A/en
Priority to US06/257,583 priority patent/US4350700A/en
Publication of JPS6350325B2 publication Critical patent/JPS6350325B2/ja
Granted legal-status Critical Current

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  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To provide an antiphlogistic agnet containing a biuret compound as an effective component.
CONSTITUTION: An antiphlogistic agnet containing a biuret compound of formula 1 (R1 is lower alkyl, lower alkenyl, methoxy, etc.; R2 is H, lower alkyl or phenyl; R3 is phenyl, benzyl, pyridyl, thiazolyl, thienyl, etc.), as an effective component. Dose: 10W2,000mg, pref. 50W1,000mg of the compound 1 per day. Two or three times per day. Administered as an oral medicine, injection, suppository for rectal application, external preparation, etc. The compound of formula 1 can be prepared by reacting a urea derivative of formula 2 or 4 with an isocyanate derivative of formula 3 or 5 in the absence or presence of a solvent (e.g. ether, dioxane, etc.), at a temperature between room temp. and about the boiling point of the solvent. For example, 1-ethyl-5-phenylbiuret can be prepared at 55% yield.
COPYRIGHT: (C)1980,JPO&Japio
JP3879379A 1979-03-31 1979-03-31 Antiphlogistic agent Granted JPS55130912A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP3879379A JPS55130912A (en) 1979-03-31 1979-03-31 Antiphlogistic agent
US06/134,411 US4287207A (en) 1979-03-31 1980-03-27 Pharmaceutical composition containing 1,3,5-substituted biuret compound
DE3012190A DE3012190C2 (en) 1979-03-31 1980-03-28 Use of 1,3,5-substituted biuret compounds
FR8007036A FR2452925A1 (en) 1979-03-31 1980-03-28 PHARMACEUTICAL COMPOSITION CONTAINING A COMPOUND 1,3-5 SUBSTITUTED FROM BIURET
GB8010753A GB2055043B (en) 1979-03-31 1980-03-31 Pharmaceutical compositions containing substituted biuret compounds
US06/257,583 US4350700A (en) 1979-03-31 1981-04-27 Pharmaceutical composition containing 1,3,5-substituted biuret compound

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3879379A JPS55130912A (en) 1979-03-31 1979-03-31 Antiphlogistic agent

Publications (2)

Publication Number Publication Date
JPS55130912A true JPS55130912A (en) 1980-10-11
JPS6350325B2 JPS6350325B2 (en) 1988-10-07

Family

ID=12535177

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3879379A Granted JPS55130912A (en) 1979-03-31 1979-03-31 Antiphlogistic agent

Country Status (1)

Country Link
JP (1) JPS55130912A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58152859A (en) * 1982-03-05 1983-09-10 Taiho Yakuhin Kogyo Kk Biuret derivative

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58152859A (en) * 1982-03-05 1983-09-10 Taiho Yakuhin Kogyo Kk Biuret derivative

Also Published As

Publication number Publication date
JPS6350325B2 (en) 1988-10-07

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