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JPS54160327A - Preparation of coenzyme q - Google Patents

Preparation of coenzyme q

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Publication number
JPS54160327A
JPS54160327A JP6857978A JP6857978A JPS54160327A JP S54160327 A JPS54160327 A JP S54160327A JP 6857978 A JP6857978 A JP 6857978A JP 6857978 A JP6857978 A JP 6857978A JP S54160327 A JPS54160327 A JP S54160327A
Authority
JP
Japan
Prior art keywords
derivative
formula
coenzyme
halogenohydroquinone
reacted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP6857978A
Other languages
Japanese (ja)
Inventor
Yoshiji Fujita
Takashi Onishi
Takuji Nishida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kuraray Co Ltd
Original Assignee
Kuraray Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kuraray Co Ltd filed Critical Kuraray Co Ltd
Priority to JP6857978A priority Critical patent/JPS54160327A/en
Publication of JPS54160327A publication Critical patent/JPS54160327A/en
Pending legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To obtain coenzyme Q, which is important pharmaceutically and takes part in electron transfer system in vivo in high yield, by the Grignard reaction of a halogenohydroquinone derinative with a prenyl derivative to form a hydroquinone derivative in one step.
CONSTITUTION: A halogenohydroquinone derivative of formula I or II: (R is methyl, methoxymethyl, α-alkoxyalkyl, or benzyl group; X is Cl or Br; m is an integer 1W9) is reacted with a metallic magnesium to give a Grignard reagent, which is then reacted with a prenyl derivative of formula III: (Y is Cl, Br, acyloxy, or tosyl group; m is the same as n) in the presence of dichlorobis (triphenyl phosphine) nickel or palladium chloride catalyst to give a hydroquinone derivative of formula IV. The derivative is, directly without purification, or purified by silica gel chromatography, if necessary hydrolyzed, and oxidized with silver oxide to form a coenzyme Q of formula V.
COPYRIGHT: (C)1979,JPO&Japio
JP6857978A 1978-06-06 1978-06-06 Preparation of coenzyme q Pending JPS54160327A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP6857978A JPS54160327A (en) 1978-06-06 1978-06-06 Preparation of coenzyme q

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6857978A JPS54160327A (en) 1978-06-06 1978-06-06 Preparation of coenzyme q

Publications (1)

Publication Number Publication Date
JPS54160327A true JPS54160327A (en) 1979-12-19

Family

ID=13377817

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6857978A Pending JPS54160327A (en) 1978-06-06 1978-06-06 Preparation of coenzyme q

Country Status (1)

Country Link
JP (1) JPS54160327A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996017626A3 (en) * 1994-12-06 1996-08-29 Ryan Pharmaceuticals Inc Water soluble ubiquinone compositions, prodrugs, and methods relating thereto

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996017626A3 (en) * 1994-12-06 1996-08-29 Ryan Pharmaceuticals Inc Water soluble ubiquinone compositions, prodrugs, and methods relating thereto

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