JPH1179962A - Two phase liquid composition for oral cavity - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject liquid composition comprising two phases consisting of an oily liquid layer comprising a specific higher fatty acid ester and a silicone compound or a hydrocarbon compound and a water layer not containing a surfactant, and useful for mouth washes, liquid dentifrice and the like. SOLUTION: This two phase liquid composition for oral cavities comprises a water layer not containing a surfactant and an oily liquid layer comprising a higher fatty acid ester liquid at 25 deg.C (preferably isopropyl myristate or the like) and a silicone (preferably methylpolysiloxane having a viscosity of 10-100,000 cs or the like) or a liquid or solid hydrocarbon (preferably squalane or the like) in an amount of 1-99 wt.% based on the total amount of the oily liquid layer in a weight ratio of 5:95 to 50:50. Just before used, the liquid composition is shaken to form fine oily drops comprising the oily liquid layer and the water layer and subsequently applied to an oral cavity. Thus, the oily drops applied to the oral cavity are collapsed and coated on the surfaces of teeth to enhance the hydrophobicity of the surfaces. The liquid composition thereby has an action for preventing or controlling the adhesion of stains and bacteria to the surfaces of the teeth.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a method for producing fine oil droplets of an oil liquid layer and an aqueous layer by shaking immediately before use, and the oil droplets which have been broken down by application in the oral cavity coat the tooth surface, The surface is modified to increase the hydrophobicity and prevent the adhesion of dirt,
The present invention relates to a two-phase liquid composition for the oral cavity that has an enhanced effect of suppressing bacterial adhesion.

[0002]

2. Description of the Prior Art The use of silicones or hydrocarbons in oral compositions as tooth coating agents has been proposed. For example, JP-A-2-209805
It describes that an oral composition containing an aminoalkyl silicone and a sarcosinate surfactant forms a hydrophobic film on the tooth surface and is useful for coloring teeth and preventing caries. Japanese Patent Application Laid-Open No. 7-48237 describes an oral composition which has a synergistically enhanced protective effect on the tooth surface when phosphoric acid monoesters and silicones are used in combination. On the other hand, it has been conventionally proposed to use hydrocarbons as a coating substance in oral compositions for the purpose of suppressing plaque deposition. For example, JP-A-63-
190817 describes an oral composition containing a surfactant and a hydrocarbon as a coating substance. However, these oral compositions have problems in that the coating substance is incorporated into the emulsified system by the surfactant, and thus the coating power on the tooth surface and the effect of preventing adhesion of dirt are reduced.

[0003] Liquid compositions which are used by shaking immediately before use in a multilayered form comprising an oil component and a water soluble component have been proposed. For example, JP-A-1-305022 describes a mouthwash comprising two phases of an oily component and a water-soluble component and containing an amphoteric cation. Also, Japanese Patent Application Laid-Open No. 7-16 / 1994
No. 5531 describes a liquid three-layer composition comprising an upper layer comprising a liquid oil component, an intermediate layer comprising a nonionic surfactant, and a lower layer comprising a hydrotope solution. However, since these are emulsified after shaking with amphoteric cations or surfactants, the emulsion does not disintegrate effectively in the oral cavity, and the coating power on the tooth surface and the effect of preventing adhesion of dirt are reduced. There's a problem.

[0004]

SUMMARY OF THE INVENTION Accordingly, an object of the present invention is to form fine oil droplets of an oil liquid layer and an aqueous layer by shaking immediately before use, and to disintegrate the oil droplets broken down by application in the oral cavity. An object of the present invention is to provide a two-phase liquid composition in which a surface is coated and surface modification is performed to enhance hydrophobicity, prevent adhesion of dirt, and enhance the effect of suppressing bacterial adhesion.

[0005]

Means for Solving the Problems In view of such circumstances, the present inventors have conducted intensive studies and as a result, they have found that they contain liquid higher fatty acid esters and silicones or liquid or solid hydrocarbons at 25 ° C. The present inventors have found that an oral liquid composition comprising two phases, an oil liquid layer and a water layer containing no surfactant, can achieve the above object, and completed the present invention. Hereinafter, the present invention will be described in more detail.The liquid composition of the present invention is prepared as a mouthwash, a liquid dentifrice, and the like. It contains solid hydrocarbons. The aqueous layer, on the other hand, relates to a two-layer oral composition containing no surfactant.

[0006]

DESCRIPTION OF THE PREFERRED EMBODIMENTS The silicones used in the present invention are long-chain methylpolysiloxane, long-chain methylphenylpolysiloxane, decamethyltetrasiloxane, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexene. One or more kinds of cyclic silicones of sasiloxane can be appropriately selected. Particularly preferably, the viscosity is from 10 to 10,000.
0 cs methylpolysiloxane, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane,
And dodecamethylcyclohexasiloxane, most preferred is octamethylcyclotetrasiloxane,
Decamethylcyclopentasiloxane and dodecamethylcyclohexasiloxane. The liquid or solid hydrocarbon may be one or two or more selected from squalane, ceresin, paraffin, microcrystalline wax, liquid isoparaffin, liquid paraffin, and petrolatum.
More than one species can be appropriately selected. Preferably, squalane, ceresin and paraffin are used. These silicones and liquid or solid hydrocarbons can be combined and compounded. The blending amount of silicones and hydrocarbons is 1 to 99% by weight based on the total amount of the oil liquid layer, preferably,
It is 10 to 90% by weight.

[0007] The higher fatty acid ester used in the oily liquid layer of the present invention is not particularly limited as long as it is liquid at 25 ° C. Isopropyl myristate, octyldodecyl myristate, isopropyl palmitate, octyldodecyl oleate are used. , Decyl oleate and the like, particularly preferably isopropyl myristate and isopropyl palmitate. The oral liquid composition of the present invention is a two-layer liquid preparation comprising an oil liquid layer and an aqueous layer, wherein the weight ratio of the oil liquid layer to the aqueous layer is preferably 5:95 to 50:50, more preferably 10:50. : 90 to 20:80, and can be produced by a conventional method.

The oil liquid layer component of the present invention may contain any oil-soluble component. For example, a fragrance, an oil-soluble coloring agent, an oil-soluble medicinal component and the like can be blended. As the flavor, menthol, carboxylic acid, anethole, eugenol, methyl salicylate, limonene, ocimene, n-decyl alcohol, citronellol, α-terbineol, methyl acetate, citronellyl acetate, methyl eugenol, cineole, linalool, ethyl linalool, vanillin, Thymol, spearmint oil, peppermint oil, lemon oil, orange oil, sage oil, rosemary oil, cinnamon oil, pimento oil, diatom oil, perilla oil, winter green oil, clove oil, eucalyptus oil and the like. These fragrances may be used alone or in combination of two or more. However, the amount of the fragrance in a range that does not impair the effect of the present invention is usually 0.01 to 30% by weight based on the oil liquid layer component. , Preferably 0.1 to 15% by weight
It is. As the oil-soluble colorant, one of red 225, yellow 204, green 202, purple 201 and the like can be used.
The species or two or more species can be appropriately selected. Oil-soluble medicinal components include bactericides such as triclosan and hinokitiol,
Examples include blood flow promoters such as tocopherol acetate and tocopherol nicotinate, and anti-inflammatory agents such as ibuprofen. These medicinal components may be used alone or in combination of two or more. However, the compounding amount in a range that does not impair the effects of the present invention is usually 0.001 to 10% by weight based on the oil liquid layer component. %, Preferably 0.01 to 1.0% by weight.

On the other hand, the aqueous layer is composed of a base material containing no surfactant, and may contain a sweetener, a pH adjuster, a binder, a thickener, a medicinal component and the like. Sweetening agents include saccharin sodium, acesulfame potassium, stevioside, and the like. In addition, these sweeteners may be used alone or in combination of two or more, but may be blended as long as the effects of the invention are not impaired. Examples of the pH adjusting agent include citric acid, phosphoric acid, malic acid, pyrophosphoric acid, lactic acid, tartaric acid, glycerophosphoric acid, acetic acid, nitric acid, or a chemically possible salt or sodium hydroxide thereof.
They may be used alone or in combination of two or more.
Sodium carboxymethylcellulose as a binder,
Cellulose derivatives such as hydroxyethyl cellulose,
Gums such as alkali metal alginate such as sodium alginate, propylene glycol alginate, xanthan gum, tragacanth gum, karaya gum, arabia gum, and karachipanan; and synthetic binders such as polyvinyl alcohol, sodium polyacrylate, carboxyvinyl polymer, and polyvinylpyrrolidone. Species or two or more species may be blended. The amount of these compounds is usually 0.001 to 1.0% by weight. In addition, sorbitol, glycerin, ethylene glycol,
Propylene glycol, 1,3-butylene glycol,
Polyethylene glycol, polypropylene glycol,
One or more of xylit, maltit, lactite and the like may be blended. The amount of these components is 1 to 60% by weight based on the aqueous layer components.

[0010]

EXAMPLES Hereinafter, the present invention will be described specifically with reference to Examples, but the present invention is not limited to the following Examples. [%] Shown below indicates [wt%] unless otherwise specified. <Preparation of Examples and Comparative Examples> In Formula 1 (two-phase mouthwash) and Formula 2 (two-phase emulsified mouthwash) shown below, higher fatty acid esters, silicones and hydrocarbons were prepared as shown in Table 1. It was blended as in Comparative Examples and prepared by a conventional method.

Formulation Example 1 Two-phase mouthwash (prepared to 10% oil liquid layer, 90% aqueous layer) Oil liquid layer Higher fatty acid ester (shown in Table 1) 4% Fragrance 1% Silicon or hydrocarbon (Table 1) 5% Water layer Glycerin 10% Saccharin sodium 0.4% Water 79.6% Total 100.0%

Formulation Example 2 Two-phase emulsifying mouthwash Oil liquid layer Higher fatty acid ester (shown in Table 1) 4% Fragrance 1% Silicon or hydrocarbon (shown in Table 1) 5% Water layer Sodium lauryl sulfate 1% Glycerin 10% Sodium saccharin 0.4% pH adjuster 0.8% Water 77.8% Total 100.0% They were used to evaluate surface modification and inhibition of bacterial adsorption. The evaluation method is described below.

<Evaluation of Surface Modification Effect by Tooth Surface Coat> Saliva preparation: Unstimulated whole saliva was collected while keeping it at −5 ° C. Collect saliva at 17,000 rpm for 10 minutes
The supernatant was obtained by centrifugation, and sterilized by ultraviolet rays. Preparation of hydroxyapatite disc: Apatite pellet (13 mmΦ) manufactured by Asahi Optical Co., Ltd. (hereinafter H
(A disk) was reacted for 17 hours at 37 ° C. while shaking in 2 ml of saliva. The HA disk was washed with water and dewatered with filter paper. Surface modification test: An HA disk was placed in 5 ml of a test solution shown in Tables 3 and 4, reacted at 37 ° C. for 30 seconds with stirring, washed with water, and air-dried. The surface free energy was measured by measuring the contact angles of three types of droplets of water, α-bromonaphthalene, and methylene iodide, and calculating by FACE surface free energy analysis software EG2 (manufactured by Kyowa Interface Science Co., Ltd.). . A smaller SFE value indicates a higher surface modifying property.

<Evaluation of bacterial adhesion inhibitory effect> Preparation of saliva: Unstimulated whole saliva was collected while keeping it at -5 ° C. Collect saliva at 17,000 rpm for 10 minutes
The supernatant was obtained by centrifugation, and sterilized by ultraviolet rays. Preparation of hydroxyapatite particles (HA particles): 96
10 mg HA particles and 100 μl in a well titer plate
KCl buffer was added and equilibrated for 6 hours. After washing the HA particles with a KCl buffer, 100 μl of saliva was added, and the mixture was reacted at 37 ° C. for 17 hours. After washing the HA particles with a KCl buffer solution, 100 μl of the test preparation was added to the HA particles after stirring, reacted at 37 ° C. for 1 minute, and air-dried. A control was prepared in the same manner using a KCl buffer as a control. Bacterial solution preparation: S. oralis ATCC cultured in BHI liquid medium
10557 was washed with KCl buffer, and the absorbance at a wavelength of 550 nm was adjusted to 0.2. Adsorption test: 120 μl of bacterial solution diluted 10-fold into HA particles
The mixture was reacted at 37 ° C. for 1 hour. 20 μl of the supernatant was serially diluted 10 times with distilled water, and 100 μl of each was spread on a BHI agar medium and anaerobically cultured. After the cultivation, the colonies were measured, and the adhesion inhibition rate was determined from the ratio of the number of added bacteria to the measured number of bacteria. Table 1 shows the results.

[0015]

[Table 1]

All of the samples shown in the test examples had higher surface modifying properties than the samples shown in the comparative examples, and inhibited the adhesion of bacteria to the tooth surface. Furthermore, the two-phase liquid compositions prepared by the usual methods with the component amounts shown in Examples 9 to 12 were evaluated by the same method. As a result, the surface modification property was higher than that of the sample shown in Comparative Example, and the tooth surface was higher. Bacterial adhesion to bacteria was suppressed.

Example 9 Mouthwashing agent Component Content (%) Oil liquid layer) Decamethylcyclopentasiloxane 5.0 Isopropyl myristate 15.0 Fragrance 0.5 Water layer) Glycerin 5.0 Saccharin sodium 0.4 Water Remainder Total 100.0

Example 10 Mouthwash Ingredient Component Amount (%) Oil Liquid Layer) Liquid Paraffin 10.0 Isopropyl Palmitate 5.0 Perfume 0.2 Water Layer) Sorvit 20.0 Water Remainder Total 100.0

Example 11 Liquid Dentifrice Component Component (%) Oil Liquid Layer) Methylphenyl Polysiloxane 7.0 Isopropyl Palmitate 13.0 Fragrance 0.5 Water Layer) Glycerin 5.0 Carboxymethylcellulose Sodium 0.05 Saccharin Sodium 0.0 4 Water balance Total 100.0

Example 12 Liquid Dentifrice Component Content (%) Oil Liquid Layer) Methyl Polysiloxane (100cs) 10.0 Isopropyl Myristate 5.0 Perfume 0.5 Water Layer) Sorvit 20.0 Xanthan Gum 0.02 Stevioside 0.0 80 Water balance Total 100.0

[0021]

According to the present invention, fine oil droplets of an oil liquid layer and an aqueous layer are formed by shaking immediately before use, and the oil droplets that have collapsed by application in the oral cavity coat the tooth surface, By performing the surface modification, it is possible to provide a two-phase liquid composition that has enhanced hydrophobicity, prevents adhesion of dirt, and has an enhanced effect of suppressing bacterial adhesion.

Claims (4)

[Claims] An oral liquid comprising two phases: an oil liquid layer containing a higher fatty acid ester liquid at 25 ° C and silicones or liquid or solid hydrocarbons, and an aqueous layer containing no surfactant. Composition. 2. The silicone is a linear dimethylpolysiloxane, a linear methylphenylpolysiloxane, a cyclic silicone, and the hydrocarbons are squalane, ceresin,
Paraffin, microcrystalline wax, liquid isoparaffin, liquid paraffin, vaseline
A liquid composition for oral cavity as described in the above. 3. The oral cavity according to claim 1, wherein the higher fatty acid ester liquid at 25 ° C. is selected from at least one of isopropyl myristate, octyldodecyl myristate, isopropyl palmitate, octyldodecyl oleate, and decyl oleate. Liquid composition. 4. The weight ratio of an oil liquid layer to an aqueous layer is from 5:95.
The liquid composition for oral cavity according to any one of claims 1, 2 and 3, wherein the ratio is 50:50.