JPH03505051A - Method and device for generating electrical pulses for biological stimulation - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

[Detailed description of the invention] Method and device for generating electrical pulses for biological stimulation Technical field TECHNICAL FIELD The present invention relates to electromedical devices, and more particularly, to electromedical devices intended to stimulate living organisms. The present invention relates to a method and apparatus for generating electrical pulses.

The invention can be used as a personal instrument in clinical and sports medicine, especially for impact prevention and treatment of diseases and pathological conditions, with coverage and coverage provided by It can be used medicinally.

Background technology Conventionally known methods for stimulating living organisms that generate electric pulses for stimulation are It is being

This method necessarily involves the following series of operations: A stimulation operation with a similar stimulus is performed, followed by a test to detect the response of the object. Stimuli are executed, triggered, amplified, and used. After this, test The stroke is repeated to evaluate the effectiveness of the treatment stimulus, and the results determine whether the treatment should be continued. (IIs-A-4505275).

The parameters of the electrical pulses generated by this method are determined during the stimulation treatment interval. The data remains unchanged and is not applicable to the current state of the object. Multiple treatment needles The sword prolongs the operating process, thereby making excessive treatment more likely. . All these factors reduce medical effectiveness.

Methods of generating electrical pulses for stimulation of nerve and muscular structures of transmission systems and organs is conventionally known, in which pulses with a specific repetition rate are not generated. each pulse is then modulated in duration to produce a specific duration. A pulse train is formed consisting of pulses with length and duty factor, in which case , the duration of the pulse with a preset repetition rate is varied (increased or ), and then the pulse train is amplified and applied to the living body, where: Depending on the individual sensitivity of the organism, an upper limit is placed on the pulse duration in the pulse train. (StJ-A-1169669).

The parameters of the stimulating pulse train should be adjusted to the maximum of the subject indulging in conditions of physiological comfort. Selected empirically by response. Individual treatment doses are not defined and therefore Surplus treatment doses are possible. Pulses do not match the current state of the object and all of these factors reduce overall medical effectiveness.

A device for generating pulses for electrical stimulation, comprising a pulse generator and a device connected to the pulse generator. It is known in the art ( Sυ-A-1069832).

A pulsed voltage with a rectangular waveform from the pulse generator is applied to one input of the modulator. and another input of the modulator receives pulses from a modulation frequency generator. the modulation At the output of the device, a pulse modulated voltage with a rectangular waveform carrier frequency is generated. and then to the amplifier and then to the living body.

In this device, pulses with highly tuned and preset parameters are be caused to occur. This is the ability to assess the state of an organism and dynamic changes in that state. Lacks a top, serially connected pulse generator, duration shaper, and power An amplitude shaper in the form of an amplifier, and an active electrode to be applied to the tissue section An electric stimulation device is known in the art (SLI-A-1011130).

In the device, a pulse generator generates pulses with a desired stimulation period. , each pulse activates the stimulus duration shaper, controls the amplitude shaper, and Generates a pulse of current that passes through.

The design of the device suffers from the same drawbacks of conventional devices discussed above. do.

Disclosure of invention The present invention provides a method for generating electric pulses for biological stimulation, and a method for generating electric pulses for biological stimulation. The purpose is to provide a device that generates electrical pulses that can be applied to the following conditions. .

This means that the method of generating electrical pulses for biological stimulation is generating pulses with a repetition rate of , modulating each pulse in duration, packets with a specific duration length and pause period between packets and a specific repetition rate. A pulse packet with a gradient change in pulse duration is set the maximum duration of a pulse with a specific repetition rate that The method is performed according to the individual sensitivity of the living body, and in the method, the present invention includes Therefore, the duration of the stimulation pulse applied to the living body is is varied according to the assessed electrophysiological parameters of the condition of the patient, and the assessment is This is achieved by stimulating the living body simultaneously.

What is the impedance of the section between the biological electrodes? f electrophysiological parameters It is convenient to use it as a , the output after the rising edge of each stimulation pulse to evaluate the impedance. The time characteristics of the electrical signal that appears are used.

Also, using a modified duration length of a packet of stimulation pulses with a specific repetition rate. It is possible to change the duration of the modified packet to a preset value. The next packet of stimulation pulses is directed to a predetermined section of the body. is allowed to be sent, and the qualified duration is greater than the preset limit. or equal to it, further stimulation is prohibited.

It also generates complementary inverted electrical pulses to affect biological sections. It is also convenient.

These and other purposes are accomplished in accordance with the present invention for generating electrical pulses for biological stimulation. A device (electrical pulse generator) that a duration modulator with one input connected to the output of the pulse generator; a stimulating pulse power amplifier having an input connected to the pulse duration modulator output; and the output is connected to an electrode that is applied to the biological section during stimulation. a first signal shaper, the input of which is connected to the output of the stimulation pulse power amplifier; The stimulation pulse is A variable duration pulse packet generator that controls the duration of pulse packets. and whose input is connected to the output of the first signal shaper, the second signal shaper generates a signal proportional to the duration of the stimulation pulse package, and The falling and falling edges are varied at a constant rate and the input is a pulse generator of variable duration. and a modulation control signal clipper with one input connected to the output. The other input is connected to the signal level presetter and the other input is connected to the output of the second signal shaper. A modulation control signal clipper output is connected to a second input of the pulse duration modulator. This is achieved by something that has something.

The electric pulse generator can further include a time discriminator, the time discriminator The device generates a stimulation complete signal at its output and one input to the time discriminator controller. and the input of the time discriminator controller is connected to the output of the stimulation pulse power amplifier. , the other input of the time discriminator is connected to the output of a variable duration pulse generator. .

The second input of the time discriminator controller or the third input of the time discriminator is the output of the pulse generator. It is possible to be connected to power.

The electrical pulse generator is a timer whose input is connected to the output of the time discriminator controller. and a controllable power supply whose input is connected to the output of the timer and which supplies the power supply. Advantageously, the second input of the timer is provided with a disabling device, the second input of the timer being connected to the output of the generator.

Additionally, the output of the time discriminator can be modulated by a control signal clipper or a second controllable power supply. It is advantageous to connect to the input.

Additionally, an electrical pulse generator is located between the electrode and the stimulation pulse power amplifier. It has been found to be advantageous to accompany the switch.

A first signal shaper and variable duration pulse generator were designed with IGFBT It can be embodied as a multivibrator, and the IGPET p-channel with a resistor at the source of the first stage transistor. With a capacitor connected to the source of the transistor, it The capacitor leads constitute the input to the first signal shaper and the multivibrator The first stage of the circuit consists of a feedback loop consisting of a diode and a capacitor connected in series. The output of the second stage of the multivibrator is a pulse of variable duration. The output of the generator is configured and the second signal shaper is implemented as an IGPBT integrator. The IGFBT integrator can be integrated into a power supply circuit and a transistor solution. with a resistor between the ground and the ground.

Also, the pulse duration modulator is an IGFET amplifier with a differentiating network at the input. Advantageously, the time constant of the circuitry is a separate IGPHT. the gate of the separate IGFET is connected to the input of the modulator, and the gate of the separate IGFET is connected to the input of the modulator; The input of the differentiating network constitutes the other input of the modulator.

The signal level presetter can include an IGPBT integrator, and the IG A FET integrator has a resistor placed between the power bus and the source of the transistor. , the input of the integrator is connected to the power supply bus via a switch.

It is appropriate to embody the pulse generator with an IGFET multivibrator. It has been found that the IGFET multivibrator includes an IGPBT. with an internal resistor-capacitor circuit in the feedback loop. a supplementary I-channel network, and also provided between the voltage source bus and the sources of the transistors. GPET, and the interconnected gates of these complementary IGFBTs the output of the amplifier is the input of the first stage of the multivibrator. Configuring the output.

In addition, the time discriminator controller consists of a resistor and an inverter connected in series, A counter, wherein the data input is connected to the inverter output and the counter control input is connected to the inverter output. is connected to the output and the counter reset input constitutes the controller input, and a second pulse counter, the data input being a reset input of the first counter; connected, the control input is connected to the output, and the reset input is connected to the output of the first counter. It is advantageous to have:

It is desirable that the time discriminator is equipped with an OR gate and a pulse counter. Yes, configure the pulse counter's reset input and the control input is connected to the output. There is.

It is also desirable that the controllable power supply includes a voltage source and a flip-flop. This means that the set input of the flip-flop is connected to the output of the voltage source via a switch. The reset input constitutes the input of the controllable power supply and the output is connected to the electronic key. The electronic key input is connected to a control input and the input of the electronic key is connected to a voltage source.

Brief description of the drawing The invention will now be described in greater detail with reference to specific embodiments and the accompanying drawings. However, in the accompanying drawings, Figure 1 (a, b, c, d, e) shows the electrical Diagram showing the time characteristics of the pulse, FIG. 2 is a block diagram of an electric pulse generator according to the present invention; FIG. 3 shows a block diagram of an electric pulse generator with a time discriminator according to the invention. figure, FIG. 4 is a diagram showing another specific example of the electric pulse generator shown in FIG. 3; FIG. 5 is a diagram showing another specific example of the electric pulse generator according to the present invention; FIG. 6 is a block diagram of an electric pulse generator with a timer according to the present invention; FIG. 7 shows another specific example of an electric pulse generator having a timer according to the present invention. Figure, FIG. 8 shows an electrical pulse generator with an embodiment of stimulation energy limitation according to the present invention. FIG. 9 is a block diagram of the device shown in FIG. 8 with stimulation disabled according to the present invention. A diagram showing an electric pulse generator, a block diagram of the pulse generator, FIG. 11 is a diagram showing a first signal shaper according to the present invention, and FIG. 12 is a diagram showing a first signal shaper according to the present invention. FIGS. 1 and 3 show the second signal shaper according to the present invention. Figure 14 shows a signal level presetter according to the present invention; , FIG. 15 shows a pulse generator according to the invention, and FIG. 16 shows a pulse generator according to the invention. FIG. 17 is a diagram illustrating a time discriminator controller according to the present invention. , FIG. 18 is a diagram showing a power supply according to the present invention, and FIG. 19 is a diagram showing a power supply according to the present invention. FIG. 20 is a diagram showing a power amplifier according to the present invention, and FIG. 21 is a diagram showing a power amplifier according to the present invention. 1 is a diagram illustrating a timer according to the present invention; FIG.

BEST MODE FOR CARRYING OUT THE INVENTION The method of generating electric pulses for biological stimulation includes the following contents.

Generate a rectangular pulse train with a specific repetition rate, and these pulses are then time modulated. are arranged into packets of a specific duration, and identify the interruption time between packets. . The duration of a pulse of a particular repetition rate within a packet is according to the individual sensitivity of the biological subject. increases linearly towards a maximum value set by one experiences an electrical sting of pleasant character, and then the duration of said pulses. The duration decreases linearly to zero.

These packets of stimulation pulses 1 (FIG. 1a) are then amplified. living body The individual stimulation pulses without contact are shown in FIG. 1b.

The amplified stimulation pulse 1 in the packet is applied to the living body and Depending on the state of the electrophysiological parameters of the plane, the stimulating pulses are 1c, ld, , we obtain the waveforms shown in the Ic diagram, but these waveforms are not correct for the electrophysiological parameters. Indicating stimulating pulses at slight, moderate and significant deviations from normal conditions There is.

The impedance between the electrodes in the cross section of the living body is the electrophysiological parameter used to evaluate the state of the living body. used as a parameter.

Time characteristics 3, 4.5 of the electrical signal appearing after each stimulation pulse 1 (first The impedance is evaluated by the stimulation pulse packet (c, Id, Ic diagram). The duration of is then changed correspondingly and compared to the standard value.

If the pulse packet duration thus modified is smaller than the standard value, the next The stimulating pulse of the kit is delivered to the patient and the modified duration is not exceeded. If so, further application of stimulation pulse packets is stopped.

To improve the therapeutic effect, the above sequence is repeated using inverted stimulation pulses. It will be done.

Dynamics of changes in disorder induced by packets of stimulating pulses The source is used to select the location of the continuous stimulus, which allows external energy to be -reducing the application of It turns out.

The electric pulse generator implements the above method herein, and according to the invention: A pulse generator 6 (second pulse generator) with its output cuff driving an input 8 of a pulse duration modulator 9 2) and a stimulation pulse power amplifier 10, the amplifier being a pulse duration modulator. Amplifier power 11 connected to output 12 of 9 and applied to part 17 of the living body during stimulation. a stimulus having an output 13.14 of an amplifier connected to each electrode 1.5.16; A pulse power amplifier 10 is provided.

The output of the amplifier 10 drives the input 18 of the signal shaping circuit 19, in which the output is The response of the body to the stimulus is determined and at the output 20 of the shaping circuit a pulse packet of A signal is generated to control the duration. The output 20 of the signal shaping circuit 19 is variable period pulse packet generator 22 whose output 23 is sent to the input of the signal shaping circuit 2 5, where the pulse corresponding to the period of the pulse packet is is generated with a constant rate of change leading and trailing edges.

The electric pulse generator further includes a modulation control signal clipper 26, and the input of the clipper is The input 27 is connected to the output 28 of the signal shaping circuit 25 and the input 29 of the clipper is connected to the signal shaping circuit 25. The clipper output 31 is connected to the level presetter 30 and the clipper output 31 of the pulse period modulator 9. The second human power 32 is driven. The output 33 of the power amplifier 10 is connected to an indicator 34. ing.

The electrical pulse generator also comprises a time discriminator 35 (FIG. 3), which discriminator Generates a stimulation interrupt (limit) signal at the power end 36 and outputs the time discriminator controller 39. It has a discriminator power 37 connected from a power 38. Turning on the time discriminator controller 39 The power 40 is connected to the output 13 of the power amplifier 10 and the input 41 of the time discriminator 35 is connected to the output 13 of the power amplifier 10. It is driven from the output 23 of the variable period pulse generator 22.

The input terminal 42 (FIG. 4) of the time discriminator control section 39 and the input terminal 43 of the time discriminator 350 ( 5) is connected to the output cuff of the pulse generator 6 (FIGS. 4 and 5).

The electrical pulse generator also includes a timer 44 (FIG. 6) whose input 45 indicates the time. A controllable electric current connected to the output 38 of the inter-discriminator controller 39 and having its human power 47 The source 46 is connected to the output 48 of the timer 44, and the input 49 (FIG. 7) of the timer It is connected to the output cuff of the gas generator 6.

The output 36 (FIG. 8) of the time discriminator 35 is the input 50 of the modulator control signal clipper 26. It is connected to the.

In another embodiment (FIG. 9), the output 36 of the time discriminator 35 is connected to the input 5 of the power supply 46. Connected to 1.

In both embodiments, the electrical pulse generator is connected to the output 13.14 of the power amplifier 10. It is inserted between electrodes 15, 16 and has two states and therefore electrodes 15 (1 6) to enable connection to the respective outputs 13 (14).

In the electric pulse generator, a first signal shaping circuit 19 and a variable period pulse generator 2 2 is incorporated as an IGFBT multivibrator, and this multivibrator The data are transistors 53.54 and 55.56 (Fig. 11), the first stage transistor. Resistors 59, 60 and transistors at sources 57, 58 of stars 53, 54 The capacitor 61 is connected to the source 57 of the capacitor 53. The other conductor 1 constitutes the first signal shaping circuit 190 input (FIG. 2). 1st stage is the feedback loop of the series-connected diode 63 (Fig. 11 and resistor 64). The output 65 of the second stage of the multivibrator is the output of the variable period pulse generator 22. This constitutes the output 23 (FIG. 2).

The second signal shaping circuit 25 includes a power supply bus 68.69 and a transistor 66.67. Transistor with resistors 72 and 73 inserted between the sources 70, 71 respectively An IGFET integrator having stars 66 and 67 (FIG. 12) is incorporated.

Pulse period modulator 9 (FIG. 2) uses transistors 74 and 75 (FIG. 13) to Equipped with a designed IGFBT (Insulated Gate Field Effect Transistor) amplifier, this The IGFBT amplifier includes a capacitor 77 and a current limiting resistor 78, and a separate one It is characterized by making the time constant variable by controlling GPBT 79. Gate 80 constitutes input 32 (FIG. 2) of pulse period modulator 9 to input cuff 6. It has a differentiation circuit network at the input 81 of this differentiation network (Fig. 13). constitutes pulse period modulator 90 input 8 (FIG. 2).

The signal level presetter 30 includes transistors 82 and 83 (FIG. 14), A resistor 88 is provided between the source 86, 87 of the star and the power bus 84, 85, respectively. ．． 89, and connected to power supply bus 84.85 via switches 91.92, respectively. an integrated IGFBT integrator with an integrator input 90 There is.

The pulse generator 6 (Fig. 2) includes transistors 93, 94, 95°96, 9 7.98 (Fig. 15), and transistors 95 and 96 are connected to the feedback loop. The amplifier is designed using an inertial network of 99 resistors and 100 capacitors. the first stage, transistor sources 103 and 104, and power supply buses 101 and 102. An IGPET multilayer using complementary IGPETs 93 and 94 provided between A vibration vibrator is incorporated. Mutual connection of complementary IGPET 93.94 The connection gates 105, 106 constitute the input 107 of the first stage and the outputs of the amplifiers 95,96. Output 108 constitutes the output of the second stage of the multi-by-break.

The time discriminator controller 39 (Fig. 3) is connected in series with the resistor 109 (Fig. 16). Equipped with an inverter 110, J and a first pulse counter 111, the pulse counter The input of the counter is connected to the output 113 of the inverter 110, and the control human power 114 is connected to the counter 111 is connected to output 115 of 111.

The reset input 116 of the pulse counter 111 is input 4 of the time discriminator controller 39. 0 (FIG. 3), and this time discriminator controller is configured to reset the pulse counter 111. a second pulse counter 117 having a data input interconnected to the output input 116; (Fig. 16) is further provided. The control human power 119 of the pulse counter 117 is It is connected to the counter output 120, and the reset manual power 121 is connected to the output of the pulse counter 111. Driven by force 115.

The time discriminator 35 (Figure 3) is an OR game) 122 (Figure 17) and the pulse counter 1 23, and the pulse counter 123 is connected to the output 125 of the OR gate 122. It has reset manual power 124.

The data input 126 of the pulse counter 123 is input to the input 43 of the time discriminator 35 (Fig. ), and the control human power 127 of the pulse counter 123 (FIG. 17) is a pulse counter. is connected to the output 128 of the printer 123.

The power supply 46 (FIG. 6) has a voltage supply section 129 (FIG. 18) and a flip-flop 130. The set input 131 of the flip-flop is connected to the voltage via the switch 132. It is connected to the output 133 of the pressure supply 129. Input of flip-flop 130 134 and 134 constitute respective inputs 47 and 51 (FIG. 6) of power supply 46; Also, the output 136 (FIG. 18) of the flip-flop 130 controls the electronic key 138. The electronic key input 139 is connected to the voltage supply 129. There is.

One set of a battery and a solar cell can be used as a voltage supply section 129, and can be used as an electronic key. 130 may be designed using transistors.

The modulation control signal clippers 26 (Fig. 2) each have a resistor 140.14 connected in series. 1.142 and a diode 143.1.44.145 (Fig. 19). Equipped with a circuit network. The other conductors of the diode 143.144゜145 have a common point. and an output 31 (FIG. 2) of the clipper 26 for the modulation control signal; It is connected to a common bus 147 via a resistor 146 (FIG. 19).

The power amplifier 10 (Fig. 2) and the indicator 34 are connected to IGP[ET] 149.150 and Equipped with an amplifier 148 (FIG. 20) designed using a transistor 151, The base 152 of the transistor is connected to the output 153 of the amplifier i48, and the base 152 of the transistor The collector 154 of is connected to the inductance coil 157 via the diode 155. Connected to tap 156. First conductor 158 of inductance coil 157 is connected to the power supply bus 159, and the second conductor 160 is connected to the first output 1 of the power amplifier 1o. 3 (FIG. 2), and the second output 14 of the amplifier is connected to a power supply bus 159 (FIG. 20). )It is connected to the. The emitter 161 of the transistor 151 is connected to the emitter 161 of the power amplifier 10. A diode connected to the third output 33 (FIG. 2) and connected to the common bus 163. 162 (FIG. 20).

The timer 44 (FIG. 7) includes a pulse counter 164 (FIG. 21), and the pulse counter 164 (FIG. 21) The counter has data input 165 connected to input 49 of timer 44 (Figure 7). Data input 165 and reset input connected to input 45 of timer 44 (FIG. 7) force 166 (FIG. 21). Output of pulse counter 164 (Fig. 21) Power 167 is connected to control power 168 and to output 48 of timer 44 (FIG. 7). Ru.

In the description of the embodiment of the individual unit of the electric pulse generator, certain components are omitted. has been done. Therefore, for example, the signal shaping circuit 19 (FIG. 2) The signal shaping circuit 25 (second (Fig. 12) is equipped with a resistor 171 (Fig. 12) and a capacitor 172. The setter 30 (Fig. 2) includes a time setting resistor 173 (Fig. 14) and a capacitor 174. The pulse generator 6 (Fig. 2) has a time setting resistor 175 (Fig. 15). and a capacitor 176.

The electrical pulse generator of the present invention shown in FIG. 10 operates as follows.

The electrical pulse generator momentarily closes switch 132 in power supply 46. This causes the output from the output 136 of the flip-flop 130 to be turned on. signal to enable the electronic key 138 and thus reduce the supply voltage to the electrical power supply. Force all units of the Lux Generator to send it.

The pulse generator 6 is similar to that known in devices of the art for similar purposes. It is characterized by low power consumption. Rectangular pulse with specific repetition rate A sequence of signals is generated at the output cuff of pulse generator 6 and then at the input of modulator 9. Sent to 8th.

The modulator 9 modulates the pulse duration arriving at its input and changes the signal level at the input 32. The duration of the pulse proportional to bell is reduced to zero. Movement of modulator 9 The operation is similar to that known for devices of the art for similar purposes.

The period modulated stimulation pulse from the output 12 of the modulator 9 is applied to the input of the power amplifier lO. A force ll is applied.

The inductance coil 157 of the power amplifier 10 is a step-up autotransformer. This autotransformer operates as a transformer at the output of the power amplifier 10. The high voltage pulse is then applied to the electrode 15. electrode】 Reference numeral 6 is a neutral (non-working) electrode, which supplies power via the output 14 of the power amplifier lO. source bus 159. The duration of the pulse on electrode 15 is determined by indicator 34. It is evaluated based on the intensity of glow discharge.

In the initial state, the pulse generator 22 emits pulses at the output 23 of a rectangular waveform. and its period sets the period of the pulse packet. The pulse generator 22 according to the signal at input 21 without affecting the duration of the stop between the to change the duration of its output pulse.

The pulses from the output 23 of the pulse generator 22 are sent to a signal shaping circuit 25 where A pulse with a leading edge that rises linearly and a trailing edge that decays linearly at It is generated at output 28.

These pulses are applied to the output 27 of the clipper 26, where the pulse amplitude is limited to the value set by the presetter 30 at the input 29 of the clipper 26. be done. The rise or fall of the signal level generated from the presetter 30 is This is generated by closing switch 92 or 91.

Thus, the clipper 26 has sloped leading and trailing edges at its output end 31. and a period corresponding to the pulse packet period. This pulse also causes a pause between pulses and a signal at the input 29 of the clipper 26. The level has a preset duration with a set minimum value.

The limited pulses are then sent to the input 32 of the modulator 9 and output at its output 12. A packet of square wave stimulation pulses is generated, and this square wave stimulation pulse is Linear increase of pulse duration within a packet up to the value set by presetter 30 and the presetter has a set period of pause between pulse packets. It is.

If there is no contact between the electrodes 15, 16 and the body part 17, the output of the power amplifier 10 will be Pulse 2 (Fig. 1b) is characterized by high frequency and relatively low attenuation, but The signal at the output of the shaping circuit 19 changes the operating mode of the pulse generator 22. It is not enough to

The time discriminator controller 39 discriminates the oscillation frequency of the signal at the input 40 and similarly Digital by the use of techniques and by the pulse sequence arriving from the output cuff of the pulse generator 6. It is characterized by high frequency discrimination accuracy due to synchronization.

At the input 40 of the controller 39, for example, the high oscillation frequency of pulse 2 (FIG. 1b) , a signal for inhibiting the time discriminator 35 and the timer 44 that can be activated is sent to the controller 3. 9 is generated at output 38 of 9.

To improve the accuracy for time interval setting, timer 44 is implemented using digital technology. is implemented and synchronized by a pulse sequence from the output cuff of the pulse generator 6.

High oscillations at the input 40 of the controller 39 during the time interval set by the timer 44 The existence of a frequency also corresponds to non-contact with the biological part 17, The timer 44 generates a signal sent to the input 47 of the power supply 46 to the output terminal 48. This causes the entire electrical pulse generator to turn off.

The contact between the electrodes 15, 16 and the body part 17 produces an electrode signal that depends on the state of the body. properties, i.e. property 3.4.5 (sections 1c, 1d).

10) and the signal at the output 20 of the signal shaping circuit 19. be sufficient to control the duration of the pulses generated by the pulse generator 22. Melt. The process at input 40 of controller 39 in this case is relatively low Since it is characterized by frequency, the timer 44 is reset and inhibited, and at the same time the timer 44 is A signal enabling the interval discriminator 35 is generated at the output 38 of the controller 39. It will be done.

A time discriminator 35 compares the duration of the pulse arriving from the pulse generator 22 with a standard value. and operate as is well known to devices of the art for similar purposes, but However, it is implemented using digital techniques to improve the accuracy of time interval generation. And it is synchronized by the pulse sequence from the output cuff of the pulse generator 6.

During stimulation, the state of the living body changes, which causes the power amplifier 10 to causes a change in the process characteristics (Fig. 1) at the output 13 of the At a certain moment, the signal at the output 20 of the signal shaping circuit 19 is Set the pulse period of the pulse from 22 to a value equal to or greater than the standard value. Set. As a result of this, the voltage applied to the control input of the modulator 9 via the clipper 26 is In the time discriminator 35 which generates the signal to be outputted at the output terminal The duration of the application will be reduced to a minimum value, and the possibility of over-granting will be reduced accordingly. decreases sexuality.

Steady state conditions are maintained while the electrodes 15, 16 are in contact with the biological part 17; In the absence of such contact, as described above, the initial conditions are automatically restored.

In order to improve the therapeutic effect, the outputs 13, 14 of the power amplifier 10 and the electrodes 15. A switch 52 is provided between 16 to interchange the activation and neutral electrodes.

The electric pulse generator of the present invention shown in FIGS. 9 and 11 to 21 is shown in FIG. The difference from what is described in the main text is that the signal from the output 36 of the time discriminator 35 is 6 is applied to input 51 of The point is to eliminate excessive application due to stimulation of a specific part 17 of the living body.

Therefore, the loss of contact between the electrodes 15 and 16 and the living body means that the electrical pulse generator By not resetting , there is therefore no need to restart.

The functional operation of the electrical pulse generators illustrated in FIGS. 2 to 8 is This example is similar to the above example because it merely represents various examples of grass.

The method and device of the present invention as described above were tested in a hospital, and the results were It is presented below.

This method deals with static and dynamic diseases of the peripheral nerves with roots and nerve dysfunction. diseases, diseases of the parts of the human body for walking due to various etiologies (inflammatory, metabolic, traumatic , hereditary, etc.), which involves a central dysfunction of the liquor dynamic. Diseases of the nervous system, dysfunction of cerebral blood circulation and its consequences, inflammation of the respiratory system, digestive system and diseases of the autonomic neutral system and diseases of other adaptive processes. It has been applied to a large group of patients with Qi status.

Osteochondrosis and static-dynamic dysfunction of the neck and lumbar spine with blood vessels and roots are peripheral nerves. It was the most common neutral system disease. Before treatment, from 3 to 5 days to 2.5 to The duration of the acute phase, which has been modified to three months, is the duration of various diseases. To the present invention The content included is as follows: stimulation time is a strictly individual element; A short acute phase is a phase that is even shorter and has the potential for good compensation of the patient's organs. It is also short-term, but can be prolonged in the case of prolonged acute stages and long-term diseases. Must be.

The check group consisted of 10 people who underwent combined therapy including reflex therapy using acupuncture. configured. Positive results after treatment include reduction of organ changes and changes in functional focal points It also encompasses psychological and emotional changes as well. Stimulation is local and partial Three to 15 treatments were applied daily, once every two days or twice a week.

Patients treated included outpatients and patients admitted to the neurology department.

The method of the invention can be used both as a sole treatment and in combination with other treatments. It reduces treatment time for both outpatient and inpatient treatment in cases of . Care was taken to ensure that the treatment was easily tolerated and no side effects were detected.

Positive results were also obtained when treating other types of pathological conditions.

In six cases, the "Blasibo" effect was verified and compared to other known similar devices. With help, electric stimulation was performed.

In all cases, a ``brassibo'' effect was detected due to the characteristics and effects of the stimulation.

The following clinical trials have been conducted to establish standards for dose suitability for individual stimuli. It was.

Twenty patients had peripheral neuroneutral dysfunction, root manifestation, and similar static-dynamic symptoms. patients with neurological symptoms, with recurrent inflammation of up to 3 days and disease duration of up to 5 years; There were 12 male and 8 female patients, including the cheerful type and the tantrum type. divided into groups.

The first group consisted of 5 males and 3 females with epithelial affected vertebrae. Treatment is performed on the affected area of the paradorsal vertebrae, and the tissue is impregnated until the resulting stable state is achieved. - Dance is calculated using only the polarity of the electrode signal (individually applied stimulation (using the Geki methodology).

The second group, consisting of two men and four women, received similar stimulation but with no electrodes. The signal polarity has changed.

The third group consisted of 5 men and 1 woman who received forced treatment after individual stimulation. (two exposures at a given polarity).

Changes in static-dynamic complaints and underlying complaints were observed pre-stimulation, post-stimulation, and with each treatment. Validated for post-period testing.

Positive treatment effects as evidenced by improved static and dynamic modulus of the vertebrae. obtained in all groups, and root escape was reduced (this was after the process (maintained at 10%, but increased again in the next period). As a result of the treatment effect, the emotional background and the patient's This was accompanied by changes in people's general satisfaction. The greatest treatment effect is in the second group of patients. It was noticeable. This includes 4 to 6 periods for the first group of patients and Compared to the 6 to IO period of patients in group 3, it was requiring a smaller number of treatment periods (3 or 4) to reach Met.

In the third group, the forced stimulation was up to 5-7% of the clinical was found to reduce achievement.

Dynamic examination of all patients after 6 to 7 months showed no recurrence. third The group noted periodic discomfort paresthesia patients with limited vertebral mobility. It was accompanied by a lot of movement.

The method of the invention allows for application with individually administered electrical stimulation; By applying reduced external energy, individualized exposure, and selection of application sites. The result is a reduction in the duration of subsequent treatment. Electric pulse of the invention The generator implements the method of the invention automatically and is therefore characterized by low power consumption.

The action of electrical pulse generators influences compensatory and reactive adaptation processes in organs. give.

Overall treatment time is reduced and hospital stay time is reduced by 5 to 10 days and more. Ru.

Electric pulse generators can be used by operators without special training and are It can also be used by the patient himself without additional instructions.

It is permissible to combine treatment with monitoring of the patient's condition through the use of electrical pulse generators be done.

Industrial applicability The invention can be used in clinical medicine and sports medicine, and As a personal device, it is especially suitable for diseases involving disorders of compensatory and adaptive processes. and for the prevention and treatment of medical conditions.

f/U, 7fi Procedural amendment (formality) August 8, 1991 Wataru Fukasawa, Commissioner of the Patent Office 1. Display of incident PCT/SU89100113 1999 Patent Application No. 509125 2. Name of the invention Method and device for generating electrical pulses for biological stimulation 3. Person who makes corrections Relationship to the case Patent applicant Address: 8-10-6 Toranomon-chome, Minato-ku, Tokyo 105, subject to amendment Translation of the description and claims 7. Contents of correction Translation of the specification and claims (no changes to the content) 8. List of attached documents Translations of the description and claims, one copy each, international search report m, mountain pass --- π/SO89100113

Claims (1)

[Claims] 1. A method of generating electrical pulses for stimulation of living organisms, the method comprising generating pulses with a specified repetition rate, each pulse being modulated by a subsequent arrangement of stimulating pulses, to produce pulse packets having a specified duration. linear increase and decrease in the duration of the pulse with a specific length of pause between pulse packets and a specific repetition rate. amplifying the stimulating pulses making up the pulse packet and setting the maximum duration of the pulses with a specific repetition rate within the pulse bucket depending on the individual sensitivity of the organism; , applying buckets of stimulating pulses to the living body through the electrodes, wherein the duration of the pulse packets applied to the living body is dependent on an evaluation of electrophysiological parameters of the condition of the interelectrode section of the living body. a method for generating electrical pulses for stimulation of a living body, characterized in that the evaluation is performed simultaneously with the stimulation of the living body; Law. 2. Method according to claim 1, characterized in that the impedance of the section between the electrodes of the living body is used as an electrophysiological parameter to evaluate the state of the living body. 3. The impedance of the section between the biological electrodes is generated after each stimulation pulse. The method according to claim 1 or 2, characterized in that the evaluation is performed based on the temporal characteristics of the electrical signal generated. 4. The modified duration of the packet of stimulation pulses is compared to the standard duration, and if the modified duration is less than the standard duration, the stimulation packet is The next packet of the pulse is applied to the organism being processed, and the modified duration is the target. If the duration is equal to or greater than the duration of the target, further processing of the organism is stopped. 3. The method according to claim 1 or 2, characterized in that: 5. The modified duration of a packet of stimulation pulses with a particular repetition rate is compared to the standard duration, and if the modified duration is less than the standard duration, the stimulation pulse is The next bucket of pulses is the predetermined set of the organism being processed. further processing of the predetermined section of the biological body is stopped when the modified duration length is equal to or greater than the standard duration length. 4. The method according to claim 3. 6. 3. Method according to claim 1, characterized in that an inverted electrical pulse is additionally generated to stimulate a section of the living body. 7. 6. Method according to claim 5, characterized in that an additional inverted electrical pulse is generated to stimulate one section of the living body. 8. An electrical pulse generator that generates pulses for stimulating living organisms. a pulse generator (6), a pulse duration modulator (9) with one input connected to the output of the pulse generator (6), and a stimulation pulse power amplifier (10). an input connected to the output of the pulse duration modulator (9) and an output connected to an electrode (15, 16), the electrode being applied to a section of biological tissue for stimulation; In the electric pulse generator provided with the electric pulse generator, the electric pulse generator The biological device is a first signal shaper (19) and detects the response of the biological body to the stimulation pulse. a variable pulse packet duration generator (22), the input of which is connected to the output of the stimulation pulse power amplifier (10), and a control signal for controlling the duration of the stimulation pulse packet is generated at the output; ), the input of which is connected to the output of a first signal shaper (19), the first signal shaper generating a signal for detecting the biological response to the stimulation pulse; A signal shaper (25) in which the signal to be shaped is a stimulation pulse pattern. The input of the second signal shaper is the output of the variable pulse packet duration generator (22), with rising and falling edges varying at a constant rate and having a duration equal to the duration of the packet packet. and a modulation control signal clipper (26) with one input connected to the signal level presetter (30) and the other input connected to the output of the second signal shaper (25). An electrical pulse generator for generating pulses for biological stimulation, characterized in that the outputs are respectively connected to second inputs of a pulse duration modulator (9). Place. 9. The electrical pulse generator comprises a time discriminator (35), the time discriminator having an output One input is connected to the third input of the force modulating control signal clipper (26) with a variable pulse pattern. The output of the packet duration generator (22) and other inputs are connected to a time discriminator (35) and a controller (39), respectively, and the inputs of the time discriminator (35) and controller (39) are connected to a stimulus pulse power amplifier. (10) and the output of the pulse generator (6). 10. 10. Electrical pulse generator according to claim 9, characterized in that the second input of the time discriminator (35) controller (39) is connected to the output of the pulse generator (6). 11. Electrical pulse generator according to claim 9 or 10, characterized in that the third input of the time discriminator (35) controller (39) is connected to the output of the pulse generator (6). 12. The electrical pulse generator comprises a timer (44) whose input is connected to the output of the time discriminator (35) and the controller (39), and a controllable power supply (46) whose input is connected to the output of the controller (39). The electric pulse generator according to claim 9 or 10, characterized in that: is connected to the output of the timer (44) to stop the power supply. 13. The electrical pulse generator is a timer (44) whose input is connected to the output of the time discriminator (35) and the controller (39), and a controllable power source (46) whose input is connected to the timer. The electric pulse generator according to claim 11, further comprising: a device connected to (44) to stop power supply. 14. The second input of the timer (44) is connected to the output of the pulse generator (6). The electric pulse generator according to claim 12, characterized in that: 15. The second input of the timer (44) is connected to the output of the pulse generator (6). The electric pulse generator according to claim 13, characterized in that: 16. Electrical pulse generator according to claim 9 or 10, characterized in that the output of the time discriminator (35) is connected to a third input of the modulation control signal clipper (26). 17. 14. Electric pulse generator according to claim 13, characterized in that the output of the time discriminator (35) is connected to a third input of the modulation control signal clipper (26). 18. 16. Electric pulse generator according to claim 15, characterized in that the output of the time discriminator (35) is connected to a third input of the modulation control signal clipper (26). 19. 13. Electric pulse generator according to claim 12, characterized in that the output of the time discriminator (35) is connected to a second input of a controllable power supply (46). 20. 14. Electrical pulse generator according to claim 13, characterized in that the output of the time discriminator (35) is connected to a second input of a controllable power supply (46). 21. 16. Electrical pulse generator according to claim 15, characterized in that the output of the time discriminator (35) is connected to a second input of a controllable power supply (46). 22. 11. The electrical pulse generator according to claim 8, 9 or 10, characterized in that the electrical pulse generator further comprises a switch (52) connected between the electrode (1546) and the stimulation pulse power amplifier (10). Electric pulse generator. 23. 16. Electric pulse generator according to claim 15, characterized in that the electric pulse generator comprises a switch (52) connected between the electrodes (15, 16) and the stimulation pulse power amplifier (10). 24. 22. Electric pulse generator according to claim 21, characterized in that the electric pulse generator comprises a switch (52) connected between the electrodes (15, 16) and the stimulation pulse power amplifier. 25. A first signal shaper (19) and a variable duration pulse generator (22) are designed as a multivibrator with IG FETs (53 to 56) and the source circuit of the first stage transistors (53, 54). A resistor (59, 60) is provided, the source of the p-channel transistor being connected to one lead terminal of a capacitor (61), the other lead terminal of which is connected to a first signal shaper (19). The first stage of the multivibrator is connected in series. the output of the second stage of the multivibrator is connected to the output of the variable duration pulse generator (22). The electric pulse generator according to claim 8, 9, or 10, characterized in that the electric pulse generator constitutes a force. 26. The second signal shaper (25) is an integrator with an IGFET transistor. 11. The electrical device according to claim 8, 9 or 10, characterized in that a resistor (72, 73) is provided, which is designed to be connected between the power supply bus (68, 69) and the source of the transistor. Pulse generator. 27. The second signal shaper (25) is an integrator with an IGFET transistor. 11. The electrical device according to claim 8, 9 or 10, characterized in that a resistor (72, 73) is provided, which is designed to be connected between the power supply bus (68, 69) and the source of the transistor. Pulse generator. 28. A pulse duration modulator (9) is designed with IGFETs (74, 75). A differentiating network is provided at the input of the amplifier, the time constant of the network being controlled by an independent FET (79), the gate of the FET being pulsed. connected to the input of the pulse duration modulator (9), the input of the differentiating network being connected to the input of the pulse duration modulator (9); Claims 8 and 9, characterized in that it constitutes a second input of the regulator (9), and is the electric pulse generator according to 10. 29. A pulse duration modulator (9) is designed with IGFETs (74, 75). an amplifier and a differentiating network at the input of the amplifier, the time determination of the network being The number is controlled by an independent FET (79), the gate of which is connected to the input of the pulse duration modulator (9), and the input of the differentiating network is connected to the second pulse duration modulator (9). 28. The electrical pulse generator of claim 27, further comprising an input. 30. A signal presetter (30) comprises an integrator designed with IGFETs (82, 83) and is connected between the power bus (84, 85) and the source of said 1GFET. Claim 8, characterized in that a resistor (88, 89) is provided, and the input of the integrator is connected to a power supply bus (84, 85) via a switch (91, 92). 9 or 10. The electric pulse generator according to 9 or 10. 31. A signal presetter (30) comprises an integrator designed with an IGFET (82, 83) and is connected between the power bus (84, 85) and the source of the IGFET. 30. The integrator input is connected to the power supply bus (84, 85) via a switch (91, 92). electric pulse generator. 32. The pulse generator (6) is a multi-byte device with IGFETs (93 to 98). The first stage of the multivibrator comprises an amplifier designed with IGFETs (95, 96), the amplifier having a feedback feedback with an internal link comprising a resistor (99) and a capacitor (100). A supplementary FET (93,94) is provided having a loop and connected between the first stage bus (95196), the gates of the supplemental FET (93,94) being interconnected to the first stage bus (95196). The output of the amplifier constitutes the input of the first stage of the multivibrator. 11. The power source according to claim 8, 9, or 10, wherein the power source comprises an output of a power source. Qi pulse generator. 33. The pulse generator (6) is a multi-byte device with IGFETs (93 to 98). The first stage of the multivibrator comprises an amplifier designed with IGFETs (95, 96), and the feedback loop of the amplifier is designed as a resistor. containing an internal network of resistors (99) and capacitors (100), with supplementary FETs (93, 94) connected between the power bus (101, 102) and the sources of the IGFETs (95, 96); The interconnected gates of FETs (93, 94) are multi-vibrated. 32. The electronic device of claim 31, wherein the amplifier constitutes an input of a first stage of the multivibrator and the output of the amplifier constitutes an output of the first stage of the multivibrator. Qi pulse generator. 34. A time discriminator (35) controller (39) comprises a resistor (109) and an inverter (110) connected in series, the data input of the first pulse counter (111) being connected to the output of the inverter (110). The control input of the first pulse counter (111) is connected to the output of the first pulse counter, and the control input of the first pulse counter (111) is connected to the output of the first pulse counter. The set input constitutes the input of the controller (39), the data input of the second pulse counter (117) is connected to the reset input of the first pulse counter (111), and the data input of the second pulse counter (117) is connected to the reset input of the second pulse counter (117). 11. The control input according to claim 9 or 10, characterized in that the control input is connected to the output of the second pulse counter and the reset input of the second pulse counter is connected to the output of the first pulse counter (111). electric pulse generator. 35. A time discriminator (35) comprises an OR gate (122) and a pulse counter (123), the reset input of the pulse counter is connected to the output of the OR gate (122), and the data input of the pulse counter is connected to the output of the OR gate (122). Configure the input and The control output of the pulse counter is connected to the output of the pulse counter. 11. The electric pulse generator according to claim 9 or 10, characterized in that: 36. A time discriminator (35) comprises an OR gate (122) and a pulse counter (123), the reset input of the pulse counter is connected to the output of the OR gate (122), and the data input of the pulse counter is connected to the time discriminator (123). 35) The electrical pulse generator according to claim 34, wherein the control output of the pulse counter is connected to the output of the pulse counter. 37. A controllable power supply (46) comprises a voltage source (129) and a flip-flop (130), the set input of which is connected to the output of the power supply (129) via a switch (132); The reset input of the flip-flop constitutes an input of a controllable power supply (46), the output of the flip-flop is connected to the control input of an electronic key (138), and the input of the electronic key is connected to a power supply (129). difference The electric pulse generator according to claim 12, characterized in that: 38. A controllable power supply (46) comprises a voltage source (129) and a flip-flop (130), the set input of which is connected to the power supply (129) via a switch (132); The reset input constitutes a control input of a controllable power supply (46), the output of said flip-flop being connected to the control input of an electronic key (138), the input of said electronic key being connected to a power supply (129). The electrical pulse generator according to claim 36, characterized in that: