JPH01283212A - Hair producing and hair growing promoter - Google Patents

Abstract

PURPOSE:To obtain a hair producing and hair growing promoter having both effects and safety, containing essence extracted from Alternanthera philoxeroides, Cassiope selaginoides or Cynomorium songaricum as an active ingredient. CONSTITUTION:Alternanthera philoxeroides, Cassiope selaginoides or Cynomorium songaricum is extracted with a water-soluble organic solvent such as ethanol or a hydrous organic solvent thereof to give essence. A base is mixed with 0.1-10.0wt.%, preferably 0.5-5.0wt.% of the essence to give the aimed substance.

Description

[Detailed Description of the Invention] (Industrial Application Field) The present invention relates to a novel hair growth/blue hair promoting agent,
Specifically, it is an object of the present invention to provide a hair growth/green hair promoting agent containing an extract extracted from the herbal medicine of Lotus root grass, Reishi grass, or Chain Yang herbal medicine as an active ingredient.

(Prior Art and Problems to be Solved by the Invention) Conventionally, various compounds and extracts of live bacteria, etc. have been used as hair growth/green hair promoters, but most of them have shown remarkable effects. In addition, those that are effective to some extent have the disadvantage that they are so irritating that they cause dermatitis, making continuous use difficult.

The present invention aims to solve this problem.

(Means for Solving the Problems) Therefore, the present inventors conducted various experimental studies in view of the current state of the art, and found that the extracts extracted from the herbal medicine of Lotus grass, Reishi grass, or Chain Yang do not solve the above problems. The present invention was completed by discovering that the present invention satisfies both effectiveness and safety.

In other words, the present invention provides a pharmaceutical composition containing, as an active ingredient, an extract extracted from a crude drug selected from lotus root grass, grass reishi, and chain yang using either a water-soluble organic solvent alone or a water-containing organic solvent thereof. This is related to paddy that promotes hair and green hair.

The present invention will be explained in detail below.

As a method for obtaining the extract applied to the present invention, the herbal medicine IOOG of Lotus grass, Reishi grass, or Chain Yang is mixed with a water-soluble organic solvent such as methanol, ethanol, propatool,
Digestion extraction is carried out three times for 2 hours each using 1 p of a water-containing organic solvent containing 50% by weight or more of a primary alcohol such as butanol, or acetone, tetrahydrofuran, dioxane, etc. alone, or the above-mentioned lower alcohol, or acetone, tetrahydrofuran, dioxane, etc. These extracts are combined, passed through a suction port, and concentrated to dryness under reduced pressure to remove the solvent to obtain a viscous extract.

One or more of the extracted extracts obtained as described above are blended as they are, or dissolved and dispersed in a suitable solvent, diluted, and blended into a base to obtain the hair growth/blue hair promoter of the present invention.

Here, the content (in terms of dry matter) of the extracted extract contained as an active ingredient in the hair growth/blue hair promoter of the present invention is o, i ~ 1
0.0% by weight, preferably 0.5-5.0% by weight.

(Effects of the Invention) The hair growth/blue hair promoting agent containing extracts from Lotus grass, Reishi grass, and Chain Yang applied to the present invention can be used to measure the density of hair growth in mice as shown in Table 1 below. In tests, it was shown to have a remarkable effect compared to other substances that are said to promote hair growth and green hair. This is because the components of the extract from the herbal medicine stimulate the hair roots, increase blood circulation around the hair roots, and improve metabolism.

[Brief explanation of the drawing]

Using 9-week-old C3 To1 mice, 4 groups were made with 10 mice per group, and 2. Ocm x 2.
The next day, apply 0.02 f of the sample (ethanol solution of the extract according to the present invention) to the area from which the hair was removed to a size of 0 cm.
On the 91st, 11th, and 14th day after application, the density of hair growth in the relevant area was measured as the degree of black increase using a colorimeter, and a conventional ethanol solution of vitamin E as a comparison substance and a control as a control were used. compared with ethanol solution. (Margins below) In addition, each sample applied in Table 1 is 99.5% containing 2% by weight of vitamin E as a comparative substance.
Ethanol solutions, B, C, and D are extracts obtained by methanol extraction of Lotus grass, Reishi mushroom, and Chain Yang, respectively.
E is a 99.5% ethanol solution as a control. Next, an example of a clinical trial is shown. Example 1 99 containing 2% by weight of lotus root extract as a sample
．． A 5% ethanol solution was used. A 44-year-old female alopecia areata patient with a hair loss area of 3 ctn in diameter on the back of her head was given a sample once a day, 3 to 3 times a day.
When 5g of the product was applied, short downy hairs appeared at the bald area after about 3 months, and after 6 months, the bald hair turned into terminal hair and disappeared from the bald area. Example 2 Samples were Chinyo extract and Reishi extract at 1:1.
99.5 containing 2% by weight of a mixture of
% ethanol solution was used. -6 = A 36-year-old male alopecia areata patient with 2.5 cm of hair loss on the top and side of his head was given one sample per day.
When 3 to 59 coats were applied at one time, vellus hairs appeared on the hair loss sites on the parietal and temporal regions after 3 months, and terminal hairs appeared after 6 months, but complete recovery was not achieved. In both Examples 1 and 2, no skin damage was observed after continuous application for 6 months. (Example) Next, a prescription example will be shown. The blending ratio is in parts by weight. Example 1 Hair tonic lotus root extract 2. (＞Menthol 0.299.5% Ethanol 60.0 Purified Water
37.8 Manufacturing method It was manufactured by dissolving Lotus root extract and menthol in 99.5% ethanol and then adding purified water. Example 2 Hair cream Reishi extract 1.0 Vaseline
7.0 Honey Low
8.0 Krystal 3
7.0 emulsifier
5.5 Purified water
41.5 Recipe Herb Reishi Extract, Vaseline, Beeswax, Crystol,
Mix emulsifier and dissolve at 80'C, then at 80'C
of purified water was gradually added to the oil phase to form a cream. Example 3 Soft Blue Lotus Herb Extract 0.5 Herb Reishi Extract 1.0 Chain Yang Extract
0.5 isopropyl myristate
10.0 Cetanol 2
．． 0 Paraffin wax 6.0 Microcrystalline wax 10.0- 7 = Emulsifier
11.0 Purified water
59.0 Manufacturing method Heat and melt the lotus root extract, Reishi mushroom extract, isopropyl myristate, cetanol, paraffin wax, microcrystalline wax, and emulsifier at 70'C.
Purified water heated above was added and stirred, and cooled to 40'C with stirring.

Claims (1)

[Claims] 1) Alternathera Philox
eroides (Mert.) Griseb. ], CassiopeSelaginoidesHo-
OK. f. etc. Thoms], and Cyno
moriumSonga-ricumRupr. 1. A hair growth promoting agent characterized by containing as an active ingredient an extract extracted from a crude drug selected from the fleshy stems of a herbal medicine using a water-soluble organic solvent alone or using these water-containing organic solvents.