JPH07178149A - Packing bag for chemicals filling bag and method for manufacturing packing bag and packing bag product - Google Patents

Abstract

PURPOSE:To provide a highly shock resistant and cushion packing bag packs a chemicals filling bag, by using a laminated sheet product having a non- adhesive part and produced by applying a remover in order to form a void between an internal layer sheet and an external layer sheet except for the marginal part. CONSTITUTION:A packing bag D has a laminated sheet product 5 produced by bonding a pair of external layer sheet 1 and a pair of internal layer sheet 2 having a similar shape to the external layer sheet 1, through an adhesive layer 4 made by applying an adhesive 4' to a inner face 3 of the external layer sheet l. The body of the packing bag is formed by laminating each inner face 6 of the internal layer sheet 2 each other and heat-sealing a marginal part 14 except for an opening 7. The adhesive layer 4 has a non-adhesive belt part 9 at the center thereof in the vertical direction, thereby enabling an outer air to go to left or right direction. A remover is applied to the outer side of the internal layer sheet 2 except for some part of a marginal part 6 and the opening 7 and enabling a void 12 to be formed between the sheet l and the sheet 2.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a packaging bag for packaging a drug solution filling bag such as a blood bag for blood transfusion or infusion, an infusion bag, a manufacturing method thereof, and a package.

[0002]

2. Description of the Related Art As a container containing a drug solution such as blood or an infusion solution for transfusion, a drug solution filling bag made of polyethylene, polypropylene or the like is used. It is distributed.

The above chemical liquid is discolored by oxygen in the air,
Alternatively, since there are many things that deteriorate, in order to prevent this, it is necessary to hermetically package the drug solution-filled bag with a packaging bag having a gas barrier property.

Conventionally, as the packaging bag, for example,
As described in 3-78258, a film made of ethylene-vinyl alcohol copolymer or the like having gas barrier properties is used as an intermediate layer, and a biaxially stretched nylon film or the like having heat resistance is formed on the outer surface thereof. There is a packaging bag made of a laminated sheet body having a three-layer structure in which a surface layer is provided and an inner surface layer made of low density polyethylene or the like having heat sealability is provided on the inner surface thereof.

However, in the case where the liquid medicine-filled bag is packed in the packaging bag, pin holes may be generated due to impacts during transportation such as distribution and various handling, and piercing accidents due to projections. There is a problem that it is not suitable as a package for a bag for filling a liquid medicine in which holes are never allowed.

Further, in order to increase the impact strength, the thickness of each layer (inner surface layer, intermediate layer, outer surface layer) of the packaging bag is made thicker, or a synthetic resin film is further laminated to make it 4
A layered structure to a 5-layered structure was also devised, but by doing so, the bending fatigue resistance deteriorates and the entire packaging bag is hardened, which makes it extremely weak against impact at low temperatures, On the contrary, the problem that pinholes and the like are likely to occur occurs, and the problem cannot be solved.

Therefore, the applicant of the present application discloses in Japanese Patent Application No. 4-89120 between the inner layer and the outer layer of the packaging bag D'where the peripheral edge 114 is adhered by a three-sided seal wrapping, etc. Except for a part, a non-adhesive portion (this portion becomes an air layer) 112 is provided (see FIG. 7) so that air can flow in from the vicinity of the storage port. It has been devised to form a packaging bag having excellent pinhole resistance by providing an air layer 112 by inserting it.

In order to form the non-bonded portion 112,
The inner layer side is provided with a release agent application section 111 in which a release agent is applied in a range corresponding to the non-adhesive section 112, and the outer layer side is provided with an adhesive application section 104 in which an adhesive is applied.
The peeling agent application section 111 is formed by bonding 1,104 to each other.
Could be the non-bonded portion 112.

After that, the drug solution filling bag C'is stored through the storage port of the packaging bag D ', and the inner layers of the lower portion 115 are heat-sealed to form a package A'. .

[0010]

However, the above-mentioned actual application
In the package A ′ described in No. 4-89120, the heat of the heat seal causes the release agent application section 111 and the adhesive application section 104 to adhere to each other. When forming the non-adhesive portion 112 between the inner layer and the outer layer, it could not be performed smoothly.

The present invention has been made in view of the above situation, and has not only pinhole resistance, impact resistance and frictional strength but also bending fatigue resistance and cushioning property, and can be manufactured at low cost. A bag and package for a drug solution filling bag that is very easy to handle, and that can always maintain the pinhole resistance and impact resistance by a simple method for blood transfusion and drip infusion, and an infusion bag. It is an object of the present invention to provide a packaging bag for packaging a drug solution filled bag such as the above, a method for producing the same, and a package.

[0012]

The present invention takes the following technical means in order to achieve the above object.

That is, as a first technical means thereof, in a packaging bag D for packaging a synthetic resin bag C filled with a drug solution B such as blood or infusion, the packaging bag body 8 has heat resistance in order from the outside. The outer layer sheet 1 has an adhesive layer 4 to which an adhesive 4'is applied, and a laminated sheet body 5 in which an inner layer sheet 2 having a gas barrier property is laminated, and the outside air flows into the adhesive layer 4. And an outer layer sheet 1 and an inner layer sheet 2 are provided.
The peeling agent 11 is applied so as to form the void 12 except for the peripheral edge portion 14 therebetween.

As a second technical means, a method for producing a packaging bag D in which a peripheral portion 14 for packaging a synthetic resin bag C filled with a liquid medicine B such as blood or infusion is heat-sealed is Inner surface 3 of heat-resistant outer layer sheet 1
An adhesive layer 4'applied side of the film 5a coated with the adhesive 4 ', and an inner layer having a gas barrier property except for at least the adhesive non-applied portion 9 intersecting the heat-sealed peripheral portion 14 at least. A predetermined portion of the outer surface side 10 of the sheet 2 is brought into contact with the release agent 11 coated side of the film 5b coated with the adhesion preventing release agent 11 to form a laminated sheet body 5, and then the laminated sheet 5 is formed. It is to manufacture by stacking the inner surface sides 6 of the inner layer sheet 2 facing each other of the body 5 and heat-sealing a predetermined portion corresponding to the peripheral edge portion 14.

A third technical means is a packaging bag D in which a peripheral portion 14 is heat-sealed except a storage portion 7 for packaging a synthetic resin bag C filled with a liquid medicine B such as blood or infusion. In the manufacturing method of 1., a predetermined portion of the inner surface side 3 of the heat-resistant outer layer sheet 1 is coated with a release agent 11 for adhesion prevention, the release agent 11 coated side of the film 5a, and the inner layer sheet 2 having gas barrier properties. The entire outer surface side 10 of the film is contacted with the adhesive 4 ′ coated side of the film 5 b coated with the adhesive 4 ′, except at least the adhesive non-coated portion 9 intersecting the heat-sealed peripheral edge portion 14. To form the laminated sheet body 5, and then the inner surface sides 6 of the inner sheet 2 facing each other of the laminated sheet body 5 are polymerized and the peripheral edge portion 1 excluding the storage portion 7
It is to manufacture by heat-sealing a predetermined part corresponding to 4.

Further, as a fourth technical means thereof, there is provided a packaging body in which the entire circumference of a synthetic resin bag C filled with a liquid medicine B such as blood or infusion is covered with a packaging bag D. The packaging bag D is an outer layer sheet 1 having heat resistance in order from the outside,
An adhesive layer 4 to which an adhesive 4'is applied, a packaging bag body 8 composed of a laminated sheet body 5 in which an inner layer sheet 2 having a gas barrier layer is laminated, and the outside air flows into the adhesive layer 4. A non-adhesive coating portion 9 is provided, and a peripheral portion 14 between the outer layer sheet 1 and the inner layer sheet 2 is provided.
The release agent 11 is applied so that the voids 12 are formed except for the above, and the inner layer sheets 2 facing each other at the peripheral edges 14 and 15 of the packaging bag body 8 are heat-sealed.

[0017]

[Operation] Main body of packaging bag D for drug solution filling bag according to the present invention
8 is composed of a laminated sheet body 5 of an outer layer sheet 1 having heat resistance and an inner layer sheet 2 having a gas barrier layer,
Since it has a sufficient wall thickness, it has excellent piercing strength, impact resistance, frictional strength, etc. due to its multi-layered structure.

Further, the release agent 11 applied to the inner layer sheet 2 of the packaging bag body 8 prevents the adhesive 4'applied to the outer layer sheet 1 from functioning, and thus the outer layer sheet 1 and the inner layer sheet 1
Since a void 12 is formed between the laminated sheet body 2 and the bag 2, even if the bag is made of the laminated sheet body 5 having a sufficient thickness, bending resistance, cushioning property, resistance to cushioning, etc. It also has excellent pinhole properties.

Further, an adhesive non-applied portion in which the adhesive 4'is not applied to the outer layer sheet 1 inner surface side 3 of the packaging bag body 8
Since 9 is provided, the space between the portion 9 and the inner layer sheet 2 also becomes a void state, and when forming the package A from the packaging bag D of the present invention, the outside air is circulated from the adhesive non-application part 9. As a result, the inflowability of air into the voids 12 is improved, the releasability by the release agent 11 is very good, and the outer layer sheet 1 in that portion is easily peeled off.
It may be possible to smoothly form an air layer between the inner layer sheet 2 and the inner layer sheet 2.

[0020]

Embodiments of the present invention will be described below in detail with reference to the drawings.

As shown in FIG. 1 and FIG. 2, the package A according to the present invention is a synthetic resin bag C filled with a drug solution B, such as a blood bag for infusion or drip, an infusion bag, and the like. It is encapsulated in D and sealed.

As shown in FIGS. 3 and 4, the packaging bag D includes a pair of outer layer sheets 1, 1 having a tapered lower portion.
And a pair of inner layer sheets 2 and 2 having substantially the same shape are laminated via adhesive layers 4 and 4 coated with an adhesive 4 ′ provided on the inner surface sides 3 and 3 of the outer layer sheets 1 and 1, respectively. A packaging bag body 8 constituted by superposing the inner surface sides 6 and 6 of the inner layer sheets 2 and 2 of the joined laminated sheet bodies 5 and 5 and heat-sealing the peripheral edge portion 14 except the storage port 7. It consists of

The adhesive layer 4 is the inner surface side 3 of the outer layer sheet 1.
Instead of being provided on the entire surface, in the present invention, a band-shaped continuous adhesive non-applying portion 9 is provided at the center in the height direction, so that the outside air can be circulated in the left-right direction of the packaging bag D. There is.

On the outer surface side 10 of the inner layer sheet 2,
The outer layer sheet 1 and the inner layer sheet 2 are coated with a release agent 11 such as silicon except for the peripheral portion 6 and a part of the storage port 7.
Will be prevented from adhering to each other, and voids 12 will be provided between them.

By applying the release agent 11 provided in the storage port 7, the portions are also applied to the outer layer sheet 1 and the inner layer sheet 2
Since they are not adhered to each other, they serve as an air circulation port 13 with respect to the outside air so that air is always flown into the void portion 12.

Storage port for the packaging bag D configured as described above
The synthetic resin bag C filled with the chemical solution B is inserted into the container 7, and the lower part 15 of the storage port 7 is heat-sealed in the same manner as described above to form the package A having the void 12 as shown in FIG. ing.

Although the peeling property of the release agent 11 is deteriorated by the heat at the time of the heat sealing, the adhesive non-application part 9 provided in the central portion in the height direction causes the non-application part 9 to be removed.
Is the starting point of peeling, and the outer layer sheet 1 and the inner layer sheet
Make sure to peel off with 2.

As the material constituting the outer layer sheet 1, biaxially stretched polyamide film, biaxially stretched polyester film, biaxially stretched polypropylene film and the like, and various films having these films laminated on the surface are used. The film improves not only heat resistance, but also puncture strength and abrasion resistance.

The inner layer sheet 2 has a structure in which a gas barrier film having a polyamide film or the like is laminated on the surface thereof. As the gas barrier film, polyvinylidene chloride, ethylene-vinyl alcohol copolymer (EVOH) or the like is used. Is used, and it is particularly preferable to use a biaxially stretched film made of an ethylene-vinyl alcohol copolymer having an excellent gas barrier property.

Further, in order to overlap the inner surface sides 6 of the inner layer sheet 2 with each other and heat seal a predetermined part easily, the inner surface side 6 is made of a known material such as polyethylene, polypropylene, ethylene-vinyl acetate copolymer and the like. It is preferable to use a linear low-density polyethylene (LLDPE) resin film having excellent heat-sealing property and strength by laminating the heat-fusible resin.

Further, as the adhesive 4'used for the adhesive layer 4, vinyl acetate type, urethane type, acrylic type, water-based urethane emulsion type or the like for dry lamination, solvent-free type urethane type adhesive or the like is used. Can be used. In particular, a urethane polyol-based two-component curable adhesive is preferable because it has excellent heat resistance.

In the above embodiment, the inner surface side of the outer layer sheet 1
Although the adhesive layer 4 is shown in 3 and the release agent 11 is provided on the outer surface side 10 of the inner layer sheet 2 respectively, those provided on the contrary are
That is, as shown in FIG. 5, the release agent 11 is applied to the inner surface side 3 of the outer layer sheet 1, and the adhesive layer 4 having the adhesive non-application portion 9 is provided on the outer surface side 10 of the inner layer sheet 2. It may be.

Further, since the adhesive non-applied portion 9 may be a starting point of peeling, it may be provided at least at a position intersecting with the peripheral edge portion 14 to be heat-sealed. The outside air may be circulated in the direction, or even if the outside air does not pass through, the non-coating portion 9 is partially provided at the intersecting position as a starting point of peeling. Of course it does not matter.

Next, an embodiment of a method of manufacturing the laminated sheet body 5 and the packaging bag body 8 which constitute the packaging bag D will be described.

FIG. 6 is an explanatory view showing a laminating step of the laminated sheet body 5 of the present invention, in which a belt-shaped biaxially stretched polyamide film 5a having a thickness of about 25 μ constituting the outer layer sheet 1 is wound around a roll 17a. Has been taken.

The film 5a has a pair of strip-shaped non-adhesive portions 9 and 9 having a constant width, which is provided inside the outer surface 3 by a width of about 1/4 of the width. An adhesive is applied to the entire surface by using a gravure roll 18 or the like, and while the adhesive layer 4 is provided, the film 5a is sent out by a roller,
While drying the solvent in the drying chamber 19, the solvent is further sent to the laminating roll 20a.

On the other hand, the biaxially stretched polyamide film having a thickness of about 25 μ constituting the inner layer sheet 2, the EVOH film having a thickness of about 15 μ, and the LL having a thickness of about 50 μ.
A strip-shaped film 5b laminated with a DPE film is wound around a roll 17b.

In a separate step, the film 5b is made smaller than the inner layer sheet 2 at a widthwise central portion on the outer surface side 6 thereof, and is smaller than the inner layer sheet 2 and has a notch 16 at one end. 11 is gravure printed.

Next, the film 5b is unwound from a roll 17b and pressure-bonded to the film 5a constituting the outer layer sheet 1 and the laminating rolls 20a and 20b.

As a result, the film 5a having the adhesive layer 4 on the surface and the film 5b having the release agent 11 applied on the surface
Since the laminated sheet body 5 in which and are attached is formed,
The sheet body 5 is wound on a roll 21.

As described above, the laminated sheet body 5 is provided with the pair of adhesive layers 4 and the release agent 11 coated portion symmetrically at the widthwise central portions of the films 5a and 5b.
The LLDPE films constituting the inner layer sheet 2 are folded in two from the center so that the LLDPE films are polymerized,
The peripheral portion 14 of the film is heat-sealed and cut at a predetermined interval to complete the packaging bag D as shown in FIG.

In the embodiment of the method for manufacturing the packaging bag D, the adhesive layer 4 is provided on the inner surface side 3 of the outer layer sheet 1 and the release agent 11 is provided on the outer surface side 10 of the inner layer sheet 2. , The film that constitutes the outer layer sheet 1 is not particularly limited.
The release agent 11 is applied to the inner surface side 3 of 5a, while the adhesive layer 4 is laminated on the outer surface side 10 of the film 5b constituting the inner layer sheet 2 except the adhesive non-applied portion 9. The laminated sheet body 5 may be manufactured.

Further, the packaging bag D may be manufactured by forming one film on each of the films 5a and 5b, one row at a time, and finally sealing on three sides.

Next, the steps until the package A is formed using the packaging bag D formed as described above will be described with reference to an embodiment.

The synthetic resin bag C filled with the chemical solution B is stored in the packaging bag D through the storage port 7, and finally the lower portion 15 of the storage port 7 is heat-sealed to be in a sealed state. At this time, since the surface of the outer layer sheet 1 is composed of a heat resistant film, the heat sealability is good.

When the bag C is stored, since the outer layer sheet 1 and the inner layer sheet 2 of the storage port 7 of the packaging bag D are bonded at the storage port central bonding portion 23, the central bonding portion By disposing a pair of adsorbents (not shown) that can be brought into contact with and separated from each other in 23, and adsorbing the adsorbents from both by vacuum or the like, it is possible to surely open the bag C and facilitate the storage of the bag C.

After that, since the adhesive non-applied portion 9 is provided between the outer layer sheet 1 and the inner layer sheet 2, when air is flowed in from the adhesive non-applied portion 9, the portion becomes a start. A void 12 is reliably formed between the outer layer sheet 1 and the inner layer sheet 2, and the package A is transported from the air inlet 13 provided in the storage port 7 to various spaces during the handling and various handling. Since air successively flows into the portion 12 naturally, the packaging bag D having a cushioning effect can be obtained. Therefore, the packaging bag D can sufficiently withstand the impact during the transportation and various handling.

Further, since the outer layer sheet 1 and the inner layer sheet 2 can be freely folded due to the provision of the voids 12, even if the total thickness of the packaging bag D is considerably large. The packaging bag D is extremely flexible and not only has excellent flex fatigue resistance, but also has excellent pinhole resistance.

Further, as described above, the packaging bag D which constitutes the packaging body A is made of the laminated sheet body 5, and because of its multi-layered structure, it has excellent piercing strength, impact resistance and frictional strength. Become.

Also, in the production, the packaging bag D for the drug solution filling bag of the present invention can be produced very easily by the three-side seal packaging or the pillow packaging, and it is considerably costly. It can be manufactured at low cost.

Since the packaging bag D for the drug solution filling bag according to the present invention corresponds to the shape, size, etc. of the synthetic resin bag C filled with the drug solution B, which is the content, as appropriate. There is no particular limitation on the shape or size.

[0052]

The packaging body in which the drug solution-filled bag according to the present invention is packaged is a packaging bag composed of a laminated sheet body composed of an outer layer sheet having heat resistance and an inner layer sheet having a gas barrier layer. Since the entire circumference of the filling bag is wrapped and hermetically sealed, the filling bag has a sufficient total thickness due to its multi-layer property, and has excellent puncture strength, impact resistance, and friction strength.

Further, since the void formed by the release agent for preventing adhesion provided between the outer layer sheet and the inner layer sheet is hollow, even if the laminated sheet body constituting the packaging bag is used. Even if the total thickness of the
It also has excellent pinhole resistance and bending fatigue resistance.

Therefore, not only the drug solution-filled bag (contents) covered with the packaging bag can be completely hermetically packaged,
It can be manufactured easily and inexpensively, can be handled easily without being bulky during transportation and various handlings, and can be very convenient and highly profitable.

Further, in the package of the present invention, the adhesive-uncoated portion to which the adhesive is not applied is provided on the inner surface side of the outer layer sheet including at least the portion intersecting with the peripheral edge portion to be heat-sealed. Therefore, there is a gap between the portion and the inner layer sheet. Therefore, when forming a package from the packaging bag of the present invention, outside air is introduced from the adhesive non-application portion, and air is inserted into the gap. The rate is improved, the peeling at the non-adhesive coated portion becomes a problem, a very easy and smooth formation of an air layer between the outer layer sheet and the inner layer sheet, and excellent retention of the state. Can be a package.

[Brief description of drawings]

FIG. 1 is a cross-sectional explanatory view showing an embodiment of a package of the present invention.

FIG. 2 is a front explanatory view of the same.

FIG. 3 is a development explanatory view showing an embodiment of the packaging bag of the present invention.

FIG. 4 is a perspective explanatory view of the same.

FIG. 5 is an explanatory sectional view showing another embodiment of the packaging body of the present invention.

FIG. 6 is an explanatory view showing an embodiment of the method of manufacturing the packaging bag of the present invention.

FIG. 7 is a front explanatory view showing a conventional example.

[Explanation of symbols] 1 outer layer sheet 2 inner layer sheet 4 adhesive layer 5 laminated sheet body 9 adhesive non-applied portion 11 release agent 12 void portion 13 air flow port 14 heat seal portion 15 heat seal portion A packaging body B chemical liquid C chemical liquid filling Bag D Packaging bag

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Takehiko Morimoto 2-7 Kitakyuhoji, Chuo-ku, Osaka-shi, Osaka Kaken Kogyo Co., Ltd. Osaka Office

Claims (4)

[Claims] 1. A packaging bag (D) for packaging a synthetic resin bag (C) filled with a liquid medicine (B) such as blood or infusion, wherein the packaging bag body (8) has a heat-resistant outer layer in order from the outside. Sheet
A laminated sheet body in which (1), an adhesive layer (4) coated with an adhesive (4 ′), and an inner layer sheet (2) having gas barrier properties are laminated.
(5), and the adhesive layer (4),
An adhesive non-applied portion (9) into which outside air flows is provided, and a space (12) is provided between the outer layer sheet (1) and the inner layer sheet (2) except for the peripheral edge portion (14). ) Is formed by applying a release agent (11) to the chemical solution filling bag. 2. A method for producing a packaging bag (D), in which a peripheral portion (14) for packaging a synthetic resin bag (C) filled with a liquid medicine (B) such as blood or infusion is heat-sealed, The adhesive layer (4 ') is applied to the entire inner surface side (3) of the outer layer sheet (1) having at least the adhesive non-application section (9) intersecting at least the heat-sealed peripheral edge section (14). A release agent (11) for adhesion prevention was applied to the adhesive (4 ') application side of the film (5a) and a predetermined portion on the outer surface side (10) of the inner layer sheet (2) having gas barrier properties. The laminated sheet body (5) is formed by bringing the release agent (11) coated side of the film (5b) into contact, and then the inner surface side of the inner layer sheet (2) facing the laminated sheet body (5). (6) A method for producing a packaging bag for a drug solution filling bag, which is produced by polymerizing each other and heat-sealing a predetermined portion corresponding to the peripheral portion (14). 3. A peripheral portion excluding a storage portion (7) for packaging a synthetic resin bag (C) filled with a liquid medicine (B) such as blood or infusion.
In the manufacturing method of the packaging bag (D) heat-sealed (14), a release agent (11) for adhesion prevention was applied to a predetermined portion of the inner surface side (3) of the heat-resistant outer layer sheet (1). Film (5
Non-adhesive coating that intersects at least the heat-sealed peripheral edge portion (14) on the release agent (11) coated side of a) and the outer surface side (10) of the inner layer sheet (2) having gas barrier properties. Department
Except for (9), the laminated sheet (5) is formed by bringing the adhesive (4 ′)-coated side of the adhesive-coated film (5 ′) into contact with the adhesive (4 ′)-coated side. Opposing inner layer sheet of laminated sheet body (5)
A package for a liquid-filled bag, which is manufactured by polymerizing the inner surface sides (6) of (2) and heat-sealing a predetermined part corresponding to the peripheral part (14) excluding the storage part (7). Bag manufacturing method. 4. A packaging body in which the entire circumference of a synthetic resin bag (C) filled with a liquid medicine (B) such as blood or infusion is wrapped with a packaging bag (D). ) Is a laminated sheet body (5) in which an outer layer sheet (1) having heat resistance, an adhesive layer (4) coated with an adhesive (4 '), and an inner layer sheet (2) having a gas barrier layer are laminated in this order from the outside. ) Is formed from a packaging bag body (8), and the adhesive layer (4) is provided with an adhesive non-applied portion (9) into which the outside air flows, and the outer layer sheet (1) and the inner layer. The release agent (11) is applied to the sheet (2) so that a void (12) is formed except for the peripheral edge (14), and the peripheral edge of the packaging bag body (8) ( A packaging body, characterized in that the inner layer sheets (2) facing each other in (14) and (15) are heat-sealed.