JPH06287105A - Cosmetic - Google Patents

Abstract

PURPOSE:To obtain a cosmetic extremely useful in preventing and improving dryness of skin due to irradiation of sunlight because of excellent light- protecting action and beutifying action. CONSTITUTION:The cosmetic contains 10 to 10wt.% sulfated trehalose or its salt and 0.01-10wt.% ultraviolet absorber.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a cosmetic, and more particularly to a summer cosmetic for preventing and improving dryness and bulkiness of the skin due to irradiation with sunlight.

[0002]

It is known that strong sunlight irradiation not only causes inflammation and pigmentation on the skin, but also reduces the barrier function of the stratum corneum, increases transepidermal water loss, and causes skin dryness. ing. When the dryness of the skin due to the irradiation of sunlight worsens, the gloss of the skin deteriorates, fine wrinkles become noticeable, and the adhesiveness of makeup deteriorates.

[0003] Conventionally, in order to prevent such effects of sunlight on the skin, the main cause of skin damage is to apply a cosmetic containing a powder that blocks ultraviolet rays such as an ultraviolet absorber and titanium oxide. The main focus is to prevent certain ultraviolet rays from reaching the skin, and no consideration has been given to the dryness of the skin due to the functional deterioration of the skin. Therefore, due to the deterioration of skin function due to infrared rays that these cosmetics cannot handle, in summer, the skin becomes oily due to the secretion of sebum, but the skin becomes bulky and the makeup becomes uncomfortable. The current situation is that many are asked.

[0004]

SUMMARY OF THE INVENTION Therefore, an object of the present invention is to provide a cosmetic having a beautiful skin effect that prevents and improves dryness of the skin due to deterioration of the skin function which cannot be prevented by merely blocking ultraviolet rays.

[0005]

[Means for Solving the Problems] As a result of intensive studies in view of the problem, the present inventors found that a cosmetic containing at least one or more of sulfated trehalose or a salt thereof and an ultraviolet absorber was applied to the skin. It was found that the above-mentioned application not only prevents damage due to ultraviolet rays but also prevents dryness due to deterioration of skin function caused by infrared rays and the like, and can maintain beautiful skin, thus completing the present invention.

Therefore, the present invention relates to a cosmetic composition comprising at least one or more of sulfated trehalose or a salt thereof in which a part or all of the hydroxyl group of trehalose is sulfated and an ultraviolet absorber.

The present invention will be described in detail below. The sulfated trehalose used in the present invention has a sulfate group (--OSO) on any or all of the hydroxyl groups of trehalose, which is a disaccharide in which two molecules of glucose are bound to each other through reducing groups.
It is a sulfate compound obtained by binding ₃ H).
The trehalose referred to here is a natural product α,
It may be an α-bonded substance (micose), an α-, β-bonded substance (neotrehalose), or a β-, β-bonded substance (isotrehalose).

The sulfated trehalose may be used in the form of its salt. When used in the form of a salt, the type of counter base includes alkali metals such as sodium and potassium, alkaline earth metals such as calcium and magnesium, amines such as monoethanolamine, diethanolamine and triethanolamine, lysine and arginine. The basic amino acids, ammonia, etc. can be exemplified, but an alkali metal can be advantageously used in consideration of solubility and the like.

As a method for obtaining such sulfated trehalose or a salt thereof, for example, the method of Schweiger RG et al. (Ca
rbohydrate Reserch 21 219-229, 1972) and the like. Hereinafter, an outline of this will be described. For example, trehalose was swollen with N, N-dimethylformamide (DMF) under a nitrogen gas stream, and a separately prepared anhydrous sulfuric acid-DMF complex was added dropwise thereto at room temperature for 4 hours.
React at 70 ° C. for about 30 minutes. After neutralizing with NaOH,
Precipitate the reaction with an organic solvent such as methanol and collect by suction filtration. The precipitate was dissolved in distilled water and then purified by ion chromatography. The degree of substitution of the sulfate group of the obtained sulfated trehalose was obtained by conducting an electric conductivity titration method with an aqueous solution of sodium hydroxide having an appropriate concentration, and the ratio of the number of moles of the sulfate group to the number of moles of the monosaccharide constituting trehalose was calculated. Express as. For example, the sulfate substitution degree of the sulfated trehalose obtained by the above method is 0.05 to 4.
It is about 0.

The thus obtained sulfated trehalose or a salt thereof is a white powder which is almost hygroscopic and odorless although its properties are slightly different depending on the degree of substitution of sulfate group, and it is hardly soluble in various organic solvents such as ethanol and acetone. It has the advantage that it can be easily incorporated into various cosmetic bases. Further, it has been found that this substance has a remarkable skin water-retaining action as shown in Japanese Patent Application No. 3-81547, and exhibits a repairing action on damaged skin. Further, this product can be safely used in the form of various preparations without causing changes with time such as discoloration, odor, decomposition and inactivation, and without any concern about human toxicity or skin damage.

In the present invention, the content of sulfated trehalose or a salt thereof is usually 10 in total with respect to the whole cosmetic.
^-5 to 10% by weight, preferably 0.01 to 1% by weight. The amount of less than 10 ^-5, reduction preventing dry skin caused by the skin functions, improving allowed to skin softening effect can not be obtained sufficiently, also be used amount exceeds 10 wt% enhancement effect was not observed It is uneconomical. As a method for incorporating it, it is preferable to dissolve sulfated trehalose or a salt thereof in an aqueous phase component and then mix it with an oil phase component.

Next, the ultraviolet absorbent similarly used in the present invention will be described. The ultraviolet absorber used in the present invention may be any one that has been conventionally used in cosmetics, and the representative compounds of such an ultraviolet absorber are as follows.

(1) Benzoic acid type ultraviolet absorber paraaminobenzoic acid, paraaminobenzoic acid monoglycerin, N, N dipropoxyparaaminoethyl benzoate,
Ethyl N, N-diethoxyparaaminobenzoate, N, N
-Butyl dimethyl paraaminobenzoate, N, N-dimethyl paraamino amyl benzoate, N, N-dimethyl para amino octyl benzoate, etc.

(2) Anthranilic acid-based UV absorber homomenthyl-N-acetylanthranilate, etc.

(3) Salicylic acid type ultraviolet absorber Amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanolphenyl salicylate, dipropylene glycol salicylate, etc.

(4) Cinnamic Acid UV Absorber Isoferulic acid, ferulic acid, caffeic acid, ethyl-4
-Isopropylcinnamic acid, methyl-2,5-diisopropyl, propyl-p-methoxycinnamic acid, isopropyl-p
-Methoxycinnamic acid, Isoamyl p-methoxycinnamic acid,
Octyl-p-methoxycinnamic acid, 2-ethoxyethyl-p-methoxycinnamic acid, cyclohexyl-p-methoxycinnamic acid, ethyl-α-cyano-β-phenylcinnamic acid, 2-ethylhexyl α-cyano-β-phenylcinnamic acid, glycerylmono-2-ethylhexanoyl-diparamethoxy Cinnamic acid, etc.

(5) Benzophenone-based UV absorber 2,4-dihydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone sodium sulfonate, 2,
4-dihydroxybenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone, 2,2 ', 4,4'
-Tetrahydroxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone sodium sulfonate, 4-phenylbenzophenone, 4-hydroxy-3-carboxybenzophenone, etc.

(6) Other UV absorbers urocanic acid, ethyl urocanate, 3- (4'-methylbenzylidene) -d, 1-camphor, 2- (2-hydroxy-5-methylphenyl) benzotriazole,
2,2′-hydroxy-5-methylethylbenzoxazole, 2,2′-hydroxy-5-methylphenylbenztriazole, 2- (2′-hydroxy-5′-t-octylphenyl) benzotriazole, 4-methoxy-4′-t-butyl Luge benzoyl methane

The cosmetic of the present invention contains the above-mentioned ultraviolet absorber in an amount of 0.01 to 10% by weight, preferably 0.1 to 1% by weight, based on the total amount of the cosmetic. This compounded amount is 0.0
If it is less than 1% by weight, the protection from ultraviolet rays becomes insufficient, and the combined effect of the ultraviolet absorber of the present invention and sulfated trehalose cannot be obtained, and even if it exceeds 10% by weight, the obtained effect remains unchanged. It is an economy.

Further, as the cosmetic base of the present invention, any base usually used in cosmetics can be used. Although not particularly specified, creams, emulsions, oils, lotions, packs, ointments and the like can be mentioned as specific examples, and creams, emulsions and oils are preferable from the viewpoint of transdermal absorbability. The main ingredients used are cream, emulsion,
In oil and ointment bases, beeswax, cetanol, olive oil, stearic acid, lanolin, petrolatum,
Liquid paraffin, glycerin, glyceryl monostearate, POE cetyl ether and the like can be mentioned. In the case of lotion base, oleyl alcohol, ethanol,
Examples of the pack agent such as glycerin, 1,3 butylene glycol, POE lauryl ether, sorbitan monolaurate, polyvinyl acetate emulsion, polyvinyl alcohol, ethanol and the like. From these raw materials, appropriate ones can be appropriately selected according to the intended dosage form, and cosmetics such as creams, emulsions, oils, lotions, packs and ointments can be prepared by a conventional method.

To describe the features of the present invention, as in the prior art, it is not limited to preventing the light from reaching the skin by the ultraviolet absorber or the light-scattering powder against the irradiation of sunlight. The UV absorber contained prevents the light from reaching the skin, and the damage to the skin caused by the light that reaches the skin without being completely prevented is quickly repaired by the highly moisturizing sulfated trehalose. It was found that they could overcome the above and applied to cosmetics.

Hereinafter, the present invention will be described in more detail with reference to examples, but it goes without saying that the present invention is not limited to the examples. The mixing ratios in the examples are all parts by weight.

Example 1. Oil-in-water cream (A) POE (30) Cetyl ether 2 Glyceryl monostearate 10 Liquid paraffin 10 Vaseline 4 Cetanol 5 2-Hydroxy-4-methoxybenzophenone 3 γ-tocopherol 0.05 BHT 0.01 Butylparaben 0.1 (B ) Propylene glycol 10 mucin 0.1 Collagen hydrolyzate 0.3 Water-soluble thoracic extract 0.2 Sulfated trehalose (sulfation degree 0.6) 0.5 Purified water 54.54 (C) Perfume 0.2 ( Manufacturing method) The respective components of (A) are combined and heated to 80 ° C. The components of (B) are combined and heated to 80 ° C. The formulation of (B) is added to the formulation of (A) and the mixture is stirred, and then (C) is added and cooled.

Example 2. Oil-in-water cream (A) POE (30) cetyl ether 2 glyceryl monostearate 10 liquid paraffin 10 vaseline 4 cetanol 5 2-hydroxy-4-methoxybenzophenone 0.02 γ-tocopherol 0.05 BHT 0.01 butylparaben 0.1 Glycosphingolipid 0.08 2-Ethylhexyl paradimethylaminobenzoate 2.5 Titanium oxide 0.4 (B) Propylene glycol 10 Mulberry peel extract 0.1 Toki extract 0.3 Pantothein-s-calcium sulfonate 0.2 Sulfation Trehalose (degree of sulfation 2.8) 0.01 Purified water 55.03 (C) Perfume 0.2 (Production method) The components of (A) are combined and heated to 80 ° C. The components of (B) are combined and heated to 80 ° C. The formulation of (B) is added to the formulation of (A) and the mixture is stirred, and then (C) is added and cooled.

Example 3. Emulsion (A) Synthetic Geiro 2.5 Cetanol 1 Squalane 4 Stearic acid 1 Polyethylene glycol monostearate (25EO) 2.2 Glycerin monostearate 0.5 Sterol glucoside 0.1 2-Ethylhexyl dimethylaminobenzazoate 2 Isoferula Acid 1 Allantoin 0.1 Zinc oxide 1 Butylparaben 0.1 α Tocopherol 0.05 Rosemary extract 0.01 Disodium edetate 0.2 (B) 1,3-Butylene glycol 3 Propylene glycol 7 Marronier extract 0. 1 Xanthan gum 0.1 Potassium hydroxide 0.2 Ascorbic acid magnesium phosphate salt 1 Arbutin 2 Chitin hydrolyzate 0.2 Sulfated trehalose (degree of sulfation 0.9) 3 Purified water 67.54 (C) Perfume 0. 1 (Production method ) Dissolve (A) and (B) at 70 ° C. with stirring. (B) is added to (A) and pre-emulsified. This is uniformly emulsified with a homomixer, and after emulsification (C) is added, the mixture is stirred and cooled to 30 ° C.

Example 4. Emulsion (A) Synthetic gallows 1.5 Cetanol 0.5 Liquid paraffin 5 Polyethylene glycol monostearate (25EO) 2 Glycerin monostearate 0.4 p-Methoxycinnamic acid-2-ethylhexyl ester 4 Titanium oxide 0.5 Butylparaben 0 .1 Vitamin A acid 0.05 BHT 0.1 (B) Malvitol 3 Propylene glycol 5 Carboxyvinyl polymer 0.3 Sodium hyaluronate 0.1 Royal jelly 0.3 Ougon extract 0.2 Sulfated trehalose (degree of sulfation 1. 7) 0.5 Purified water 76.44 (C) Perfume 0.1 (Production method) (A) and (B) are dissolved at 70 ° C. with stirring. (B) is added to (A) and pre-emulsified. This is uniformly emulsified with a homomixer, and after emulsification (C) is added, the mixture is stirred and cooled to 30 ° C.

Example 5. Lotion (A) POE (20) sorbitan monolaurate 1.5 POE (20) lauryl ether 0.5 ethanol 10 p-methoxycinnamic acid-2-ethylhexyl 3 sodium isoferurate 0.2 stearyl glycyrrhetinate 0.5 α- Tocopherol 0.02 Perfume 0.1 (B) Glycerin 5 Propylene glycol 4 Citric acid 0.15 Sodium citrate 0.1 Ascorbic acid magnesium phosphate 3 Placenta extract 0.1 Bovine blood deproteinization extract 0.1 Sulfation Trehalose (Sulfation degree: 0.6) 3 Purified water 68.63 (Production method) The components of (A) are combined and dissolved at room temperature. on the other hand,
Each component of (B) is also dissolved at room temperature and added to the formulation of (A) to be solubilized.

Example 6. Lotion (A) POE (20) sorbitan monolauric acid ester 1.5 POE (20) lauryl ester 0.5 ethanol 8 2-ethylhexyl paradimethylaminobenzoate 2 4-methoxy-4'-t-butyl-dibenzoylmethane 3 γ-oryzanol 0 .3 γ Tocopherol 0.02 (B) Glycerin 5 1,3-butylene glycol 4 Citric acid 0.15 Sodium citrate 0.1 Ethinyl estradiol 0.001 Genoshoco extract 0.1 Serine 0.1 Sulfated trehalose (sulfate) Degree of conversion 0.7) 0.5 Dye 0.1 Purified water 74.629 (Production method) The components of (A) are combined and dissolved at room temperature. on the other hand,
Each component of (B) is also dissolved at room temperature and added to the formulation of (A) to be solubilized.

Example 7. Packing material (A) Polyvinyl alcohol 15 Purified water 40 Bisapol 0.5 Vitamin A acid 0.2 γ-tocopherol 0.02 Sodium isoferurate 0.1 Titanium oxide 10 (B) Ethanol 41,3-butylene glycol 4 POE ( 8) Polyoxypropylene glycol (55) 3 Peony extract 0.3 Aloe extract 0.4 Tonin extract 0.3 Ginkgo extract 0.4 Sulfated trehalose (Sulfation degree 3.5) 0.5 Purified water 21.28 (Production method ) (A) is dispersed and dissolved at room temperature. (B) is added to this and it melt | dissolves uniformly.

Example 8. Lotion POE (80) Hydrogenated castor oil 2 Sulfated trehalose sodium salt (degree of sulfation 0.8) 1 Sodium oxybenzone sulfonate 0.5 Methylparaben 0.2 Ethanol 10 Perfume 0.1 Purified water 86.2 (Production method) Above The ingredients are dissolved by stirring at room temperature.

Example 9. Examination of light protection effect in guinea pigs 6 Hartley white guinea pigs (male, weight 300 g)
Before and after), the light protection effect of the cosmetic composition of the present invention was examined.
That is, UV irradiation of 3 MED was performed using a guinea pig whose MED (minimum erythema dose) was previously measured under the conditions of UV irradiation with an SE lamp. The UV-irradiated site was divided into 4 parts in advance, each was untreated, 0.03 ml of the lotion of Example 8 was applied, and the lotion of Example 8 in which sodium oxybenzone sulfonate was replaced with purified water (Comparative Example 1) was 0. 0.03 ml was applied to the cosmetic lotion of Example 8 in which the sulfated trehalose of Example 8 was replaced with purified water (Comparative Example 2). The erythema was observed 24 hours after the irradiation. As an observation standard, remarkable red flesh:
2, obvious erythema: 1, suspicious erythema: 0.5, normal:
A score of 0 was given, and the average of the scores was taken for evaluation. Furthermore,
The skin condition was observed 72 hours after the irradiation, and the number of individuals showing an abnormal condition due to dryness such as desquamation was counted and evaluated. The results are shown in Table 1. It is clear that the lotion of the present invention has an excellent light protection effect.

[0031]

[Table 1]

Example 10. Use test Twenty healthy men (aged 20 to 48) were subjected to a light protection use test under actual use conditions under the sunlight on the coast in August. That is, the outer side of the right upper arm is divided into four, and no treatment is performed.
The treatments of application of the lotion of Example 8, application of the lotion of Comparative Example 1 and application of the lotion of Comparative Example 2 were performed, and free movement was performed for 1 hour under the irradiation of sunlight, and after 1 week, the skin condition was observed. A score of 2 points was given to those who showed significant improvement, 1 point to those that showed improvement, and a score of 0.5 point to those that showed slight improvement compared to the untreated site. The results are shown in Table 2. As can be seen from these results, the cosmetic of the present invention has an excellent light protection effect.

[0033]

[Table 2]

[0034]

EFFECT OF THE INVENTION The cosmetic composition of the present invention has excellent light-protecting effect and skin-beautifying effect, and thus is very useful as a summer cosmetic composition.

Continuation of the front page (51) Int.Cl. ⁵ Identification number Reference number within the agency FI Technical indication location A61K 7/48 9051-4C (72) Inventor Ohira Hamasaki 27 Takashimadai, Kanagawa-ku, Yokohama, Kanagawa Prefecture 1 Pola Chemical Industry Co., Ltd. Inside Yokohama Institute Co., Ltd. (72) Inventor Toru Sakai 27-1 Takashimadai, Kanagawa-ku, Yokohama, Kanagawa Prefecture Pola Kasei Co., Ltd. Inside Yokohama Laboratory (72) Hideo Gootome 27-1 Takashimadai, Kanagawa-ku, Yokohama, Kanagawa Prefecture Pola Chemical Industry Co., Ltd. Yokohama Research Laboratory (72) Inventor Hideo Matsuura 27 Takashimadai, Kanagawa-ku, Kanagawa City, Kanagawa Prefecture 1 Pola Chemical Industry Co., Ltd. Yokohama Research Laboratory (72) Inventor, Kuri 27 Takashimadai, Kanagawa-ku, Yokohama, Kanagawa Prefecture Address 1 POLA CHEMICAL INDUSTRIAL CO., LTD. Yokohama Research Institute (72) Inventor Mitsuko Sasakawa Takashimadai, Kanagawa-ku, Yokohama, Kanagawa 27 Address 1 POLA CHEMICAL INDUSTRIAL CO., LTD. Yokohama Research Center (72) Inventor Hideo Kurita, Kanagawa-ku Yokohama, Kanagawa 27 Takashimadai 1 Pola Chemical Industry Co., Ltd. Yokohama Research Center

Claims (3)

[Claims] 1. A cosmetic comprising at least one of sulfated trehalose or a salt thereof in which a part or all of hydroxyl groups of trehalose is sulfated, and an ultraviolet absorber. 2. The cosmetic according to claim 1, wherein the content of sulfated trehalose or a salt thereof is 10 ⁻⁵ to 10% by weight based on the total amount of the cosmetic. 3. The cosmetic according to claim 1, wherein the total content of the ultraviolet absorber is 0.01 to 10% by weight with respect to the total amount of the cosmetic.