JP7227978B2 - Sample pretreatment machine and analysis system - Google Patents

Description

TECHNICAL FIELD The present invention relates to a sample pretreatment device for filtering a sample liquid and filtering out a predetermined component through a filter.

For example, when measuring the amount of ATP or the amount of microorganisms present, pretreatment is performed to increase the concentration of predetermined components in the sample liquid by filtering the sample liquid with a filter.

For such pretreatment, a sample container having a filter inside, in which a sample liquid is stored, is connected to the sample container, and suction is performed so that the sample liquid in the sample container passes through the filter and is filtered. A sample preprocessor that performs This filtration concentrates the sample liquid in the sample container.

By the way, in the measurement for the purpose of detecting ATP or microorganisms, even if the error in the amount of the sample liquid is minute, there is a possibility that a large measurement error occurs.

In addition, since a sample container containing a different sample liquid is connected to the suction terminal for each filtration, ATP and microorganisms adhering to the suction terminal during the previous filtration may contaminate the currently attached sample container. have a nature. In order to achieve more accurate ATP measurement and microorganism detection, it is becoming necessary to prevent such contamination.

JP-A-2006-133232

SUMMARY OF THE INVENTION The present invention has been made in view of the problems described above, and provides a sample pretreatment apparatus that can accurately measure the amount of sample liquid after filtration and improve the accuracy of subsequent measurements. intended to

That is, the sample pretreatment device according to the present invention, which filters a sample liquid and filters a predetermined component through a filter, includes a bottle in which the sample liquid is stored, and a proximal end attached to the bottle, and the filter provided therein. A connection mechanism for connecting between a sample container having a cylindrical cartridge mounted thereon and a suction source is provided, wherein the connection mechanism connects between the distal end side of the cartridge and the suction source, and the sample container includes and a mounting surface on which the bottle is attached and the cartridge is arranged at a predetermined position with respect to the suction terminal.

With such a configuration, the cartridge can always be arranged at the same position with respect to the suction terminal simply by attaching the bottle to the attachment surface. Therefore, it is possible to improve the positional accuracy of the cartridge when the sample liquid is aspirated only by a simple mounting work, and to accurately measure the amount of the sample liquid in the cartridge simply by detecting the liquid level height in the cartridge. It becomes possible to

As a specific configuration for facilitating the enhancement of the positional accuracy of the cartridge during suction and for simplifying the labor for attaching the sample container to the connection mechanism, the connection mechanism may be connected to the suction terminal. and a positioning base fixed at a position spaced apart from the terminal plate by a predetermined distance and having the mounting surface formed thereon, the positioning base facing the suction terminal to the cartridge is formed with an insertion hole into which is inserted.

The suction terminal, which is in direct contact with the cartridge and causes contamination, can be easily sterilized, and the positional relationship between the mounting surface and the suction terminal does not change even if the sterilization process is performed. In order to make it difficult, it is sufficient that a main body having the suction source and a mounting surface on which the connection mechanism is mounted is provided, and the connection mechanism is detachably attached to the mounting surface.

For example, if only the suction terminal is detachable from the main body, there is a possibility that it will be attached at a position different from the initial position when it is reattached to the main body after sterilization or the like. Such mounting errors cause variation in the positional relationship between the cartridge and the suction terminal. On the other hand, if the entire connection mechanism is made detachable as described above, the positional relationship between the mounting surface and the connection terminal can be maintained. can be kept.

In order to easily connect the suction terminal to the suction source after the connection mechanism is sterilized, a suction port opened in the mounting surface and connected to the suction source by a suction pipe; a positioning structure provided between the connection mechanism and the main body for positioning the suction terminal so that the suction terminal is connected to the suction port in a state where the connection mechanism is mounted on the mounting surface. If it is

In order to decompose the ATP remaining in the connection mechanism by autoclaving and prevent measurement errors from occurring, the connection mechanism should be made of a material having a heat-resistant temperature that can be treated with an autoclave. .

In order to be able to accurately detect the liquid level of the sample liquid in the cartridge, to reduce the manufacturing cost compared to the conventional one, and to realize miniaturization, a reflective type sensor that detects the liquid level of the sample liquid in the cartridge is required. and a sensor holder that fixes the liquid level sensor to the main body so that the liquid level detection position of the liquid level sensor corresponds to the target liquid level. Just do it.

In order to complete filtration in separate cartridges for a large number of sample liquids in a short period of time, the connection mechanism is provided with a plurality of suction terminals, and the sample container is connected to each suction terminal. It is configured to be able to perform a suction operation at the same time.

In order to detect that there is a leak in the connection between the suction terminal and the suction source and to stop the suction operation, for example, a The apparatus further includes a tray for receiving filtrate of the sample liquid leaked from the suction pipe, and a filtrate detection sensor for detecting whether or not the filtrate is present in the tray. As the filtrate detection sensor, various types such as an optical type, a capacitance type, or a resistance detection type can be used.

An analysis system comprising a sample pretreatment device according to the present invention and a sample analysis device for measuring a sample liquid concentrated by the sample pretreatment device can achieve measurement accuracy such as ATP measurement and microorganism detection. can be improved than before.

As described above, with the sample pretreatment apparatus according to the present invention, it is possible to always maintain the same positional relationship between the suction terminal and the cartridge simply by attaching the bottle of the sample container to the attachment surface. Become. Therefore, it is possible to reduce the time and effort for connection, and improve the accuracy of the amount of sample liquid measured in the cartridge. For this reason, it is possible to further improve the accuracy of subsequent measurements, such as ATP measurement and microorganism detection, as compared to conventional techniques.

1 is a schematic diagram showing a sample pretreatment device and an analysis system according to a first embodiment of the present invention; FIG. 1 is a schematic perspective view showing a sample pretreatment device according to a first embodiment of the present invention; FIG. 4 is a schematic perspective view showing a state in which a sample container is connected to the sample pretreatment device according to the first embodiment; FIG. FIG. 4 is a schematic perspective view showing a state in which the connection mechanism is removed from the sample pretreatment device according to the first embodiment; FIG. 2 is a schematic perspective view showing the connection mechanism of the sample pretreatment device according to the first embodiment in a detached state; 1 is a schematic cross-sectional view of a sample pretreatment device according to a first embodiment; FIG. FIG. 4 is a schematic partial cross-sectional view enlarging the periphery of the connection mechanism of the sample pretreatment device according to the first embodiment; FIG. 5 is a schematic cross-sectional view enlarging the periphery of the cartridge and the suction terminal in a modification of the sample pretreatment device according to the first embodiment;

DESCRIPTION OF SYMBOLS 100... Sample pretreatment apparatus 1... Main body 11... Mounting surface 12... Suction port 13... Receptacle 14... Filtrate detection sensor 2... Connection mechanism 22... Suction terminal 26 ...Mounting surface 31 ...Liquid level sensor 4 ...Engaging structure 41 ...Engaging hole 42 ...Positioning pin S ...Sample container S1 ...Bottle S2 ...Cartridge F ··filter

An analysis system and a sample pretreatment device 100 according to a first embodiment of the present invention will be described with reference to FIGS. 1 to 7. FIG. The analysis system of the first embodiment concentrates a sample liquid by filtration, and analyzes the amount of predetermined components such as ATP and microorganisms in the concentrated sample liquid.

As shown in FIG. 1, this analysis system includes a sample container S containing a sample liquid, a sample preprocessor 100 for filtering and concentrating the sample liquid, and a sample liquid for measurement of the concentrated sample liquid. and an analysis device 101 .

As shown in FIGS. 1 and 6, the sample container S includes a bottle S1 in which a sample liquid is stored and a cartridge S2 in which a filter F is formed. Here, the cartridge S2 is detachably attached to the bottle S1 in the sample container S, and is removed from the bottle S1 after filtering and concentrating the sample liquid, and is also used in subsequent measurements by the sample analyzer 101. It is the part that can be As shown in FIG. 1, the sample container S including the bottle S1 and the cartridge S2 is placed in the sample pretreatment apparatus in a state where the top opening of the bottle S1 is closed with the lid S12 to prevent contamination of the sample liquid from the outside. 100 , the sample liquid stored in the bottle S<b>1 of the sample container S is sucked by the sample pretreatment device 100 . By this suction operation, most of the sample liquid in the bottle S1 is filtered by the filter F in the cartridge S2. The lid S12 has an air hole S13 formed in the side surface of the bottle S1 for allowing air to flow from the outside into the bottle S1. can create the pressure differential required for Predetermined components in the sample liquid are filtered onto the filter F, and most of the liquid components are discarded as filtrate. On the other hand, part of the liquid component of the sample liquid that has not passed through the filter F remains in the cartridge S2 in a predetermined amount.

After the filtration by the sample pretreatment device 100 is completed, the cartridge S2 is removed from the bottle S1, and a cap S21 is attached to the tip of the cartridge S2 so as to prevent contamination of the filter F from the outside of the cartridge S2. be done. The cartridge S2 itself with the cap S21 is housed in the sample analyzer 101 and used. Then, the concentrated sample liquid in the cartridge S2 is dispensed in the sample analyzer 101, and the amount of ATP and microorganisms is measured by adding a reagent or the like.

Details of the sample pretreatment device 100 will be mainly described below. As shown in FIGS. 2 to 4 and 6, the sample pretreatment device 100 is mounted on a main body 1 having a touch panel display M on the front surface thereof for indicating the control state and the like, and a mounting surface 11 on the front side of the main body 1. , a connection mechanism 2 for connecting between a sample container S consisting of a bottle S1 and a cartridge S2 in which a sample liquid is stored and a pump in the main body 1 .

A mounting surface 11 extending in a horizontal plane is formed on the use end side of the main body 1, and as shown in FIGS. . As shown in FIGS. 4 and 5, a suction port 12 connected to a pump (not shown), which is a suction source, by a connecting pipe L1 is opened in the mounting surface 11. The connection mechanism 2 is provided with the suction port 12. The suction terminal 22 is connected.

As shown in the cross-sectional view of FIG. 5, the filtrate filtered in the cartridge S2 passes through the connection pipe L1 in the main body 1 to reach the fluid control mechanism FC, and from the fluid control mechanism FC through the filtrate discharge pipe L2. Ultimately, the filtrate is discharged to the outside from the filtrate discharge terminal 15 projecting from the use end side of the main body 1 . A waste liquid tank and a pump (not shown) are connected to the filtrate discharge terminal 15 . Here, the fluid control mechanism FC is composed of a plurality of valves and the like, and switches which suction port 12 to perform the suction operation.

A tray 13 is provided below the connection pipe L1 and the filtrate discharge pipe L2, and is configured to receive the leaked filtrate. For example, an optical filtrate detection sensor 14 is mounted on the receiving tray 13 so that the sensor surface faces the bottom side. When the filtrate detection sensor 14 detects the filtrate, a control mechanism (not shown) stops the operation of the pump and enters a locked state.

As shown in FIGS. 2 to 7, not only the connection mechanism 2 but also a sensor holding a liquid level sensor 31 for detecting the liquid level in the cartridge S2 of the sample container S attached to the connection mechanism 2 is mounted on the mounting surface 11. As shown in FIGS. The holder 3 is also fixed.

Detailed structures of the sample container S, the connection mechanism 2, and the sensor holder 3 will be described below.

As shown in FIGS. 1, 6, and 7, the sample container S includes a substantially cylindrical bottle S1 in which the sample liquid is stored, and a narrow cylindrical bottle S1 having a smaller diameter and smaller volume than the bottle S1. None, and a cartridge S2 in which a filter F is provided in the central portion thereof. In this sample container S, the center of the bottom surface of the bottle S1 and the base end side of the cartridge S2 are screwed together, and a part of the base end side of the cartridge S2 penetrates into the bottom surface of the bottle S1. fixed in the state. The positional relationship between the bottle S1 and the cartridge S2 is not limited to this example. For example, the cartridge S2 may be screwed to the outer peripheral side of the bottom surface of the bottle S1. As shown in FIG. 7, the bottom surface of the bottle S1 is formed with an abutment surface S11 with which the base end surface of the cartridge S2 abuts to prevent the cartridge S2 from further entering the bottle S1. Therefore, when the cartridge S2 is sufficiently screwed into the bottle S1, the length of the cartridge S2 protruding from the bottom surface of the bottle S1 is substantially constant. In other words, the cartridge S2 is positioned with respect to the bottle S1 by the contact surface S11 formed on the bottom surface of the bottle S1. Further, when the cartridge S2 is screwed to the bottle S1, the bottom surface of the bottle S1 protrudes outward from the cartridge S2 and forms a shoulder portion of the sample container S. As shown in FIG.

The connection mechanism 2 is configured so that a plurality of sample containers S can be arranged in a line and attached as shown in FIG. As shown in FIG. 5, the connection mechanism 2 includes a terminal plate 21 provided with a plurality of suction terminals 22 to which the tip of the cartridge S2 is attached, and a terminal plate 21 at a predetermined distance from the terminal plate 21 on the bottom of the bottle S1. and a positioning table 25 forming a mounting surface 26 .

The terminal plate 21 has a long plate shape, and in the first embodiment, six suction terminals 22 are arranged in a line. As shown in the cross-sectional views of FIGS. 6 and 7, the suction terminal 22 has a thick cylindrical portion 23 connected to the suction port 12 opening on the mounting surface 11, protruding from the thick cylindrical portion 23, and fitted to the tip of the cartridge S2. and a narrow cylindrical portion 24 to be joined. A portion of thick cylindrical portion 23 is embedded in terminal plate 21 , and thin cylindrical portion 24 is configured to protrude outside terminal plate 21 . Further, as shown in FIG. 7, a linear groove 2S extending in the generatrix direction is formed in the outer surface of the tip portion of the thin cylindrical portion 24 that is inserted into the cartridge S2. After the suction operation for the sample container S is completed, external air flows into the suction terminal 22 and the suction port 12 through the gap between the groove 2S and the inner peripheral surface of the cartridge S2. Therefore, the filtrate remaining in the suction terminal 22 and the suction port 12 can flow toward the connecting pipe L1. Therefore, it is possible to prevent the sucked filtrate from returning to the cartridge S2 side when the tip of the cartridge S2 is pulled out from the suction terminal 22 .

Further, a positioning structure 4 is formed between the terminal plate 21 and the mounting surface 11 to determine the position of the connection mechanism 2 on the mounting surface 11 in the direction of the surface plate. In the first embodiment, the positioning structure 4 is composed of two engaging holes 41 provided in the terminal plate 21 and two positioning pins 42 protruding from the mounting surface 11 . By engaging the positioning pin 42 with the engagement hole 41 and fixing the connection mechanism 2 to the mounting surface 11 with a fixing screw, the suction terminals 22 are communicated with the suction ports 12 and the suction ports 12 are connected. A surrounding O-ring can be crushed to seal. Moreover, the positioning structure 4 allows the connection mechanism 2 to be arranged not only in the arrangement direction of the suction ports 12 but also in the depth direction orthogonal thereto. Therefore, the distance from a plurality of liquid level sensors 31, which will be described later, arranged in the center of the mounting surface 11 can also be kept constant.

As shown in FIG. 5, the positioning table 25 includes a plurality of posts 2A erected with respect to the terminal board 21, and a mounting plate 2B provided on the posts 2A. The top side of the mounting plate 2B forms a mounting surface 26 on which the shoulder portion of the sample container S, that is, the bottom surface of the bottle S1 is placed, as shown in FIGS. The mounting surface 26 is configured to be parallel to a virtual plane formed by the face plate portion of the terminal plate 21 and the tip ends of the thin cylindrical portion 24 of the suction terminal 22 . The mounting plate 2B is formed with insertion holes 27 for inserting only the cartridge S2 portion of the sample container S toward the terminal plate 21 at positions corresponding to the respective suction terminals 22. As shown in FIG. The inner diameter of the insertion hole 27 is substantially the same as the outer diameter of the cartridge S2, so that the cartridge S2 can be inserted straight. Therefore, the leading end of the cartridge S2 can be easily inserted into the thin cylindrical portion 24 of the suction terminal 22 simply by placing the sample container S on the positioning table 25 . Therefore, as shown in FIGS. 3, 6, and 7, simply by placing the shoulder portion of the sample container S on the mounting surface 26 of the positioning table 25, the thin suction terminal 22 can be attached to the tip portion of the cartridge S2. As the cylindrical portion 24 is inserted, the inserted length becomes constant. In this manner, simply by attaching the sample container S to the attachment surface 26, the positional relationship between the suction terminal 22 and the cartridge S2 is always kept constant.

Further, since the column 2A of the positioning base 25 is fixed to the terminal plate 21 by screws, as shown in FIGS. can be removed from Therefore, even if the connection mechanism 2 is attached to or detached from the main body 1, the positional relationship between the suction terminal 22 and the attachment surface 26 does not change. Furthermore, the terminal block, the suction terminal 22, and the positioning block 25, which constitute the connection mechanism 2, are each made of, for example, only a metal material, and are unlikely to be deformed even if the temperature is raised by autoclaving. For this reason, the positional relationship between the suction terminal 22 and the mounting surface 26 is unlikely to change even if the suction terminal 22, which is in direct contact with the cartridge S2, is autoclaved to eliminate residual ATP or to sterilize microorganisms. The connection mechanism 2 is not limited to being made of only metal materials, and may be made of a resin material such as PEEK that can withstand autoclaving.

The sensor holder 3 fixes and holds the liquid level sensor 31 at a position corresponding to each suction terminal 22 as shown in FIGS. In the first embodiment, the sensor holder 3 is fixed to the mounting surface 11 and is basically not removed. As shown in FIG. 7, the liquid level sensor 31 is a reflective sensor that detects the presence or absence of the liquid level by allowing light to enter from the side surface of the cartridge S2 and detecting the reflected light. The sensor holder 3 is arranged such that the sensor surface is in contact with the side surface of the cartridge S2 or a very small gap is formed. Since the liquid level sensor 31 is arranged in this manner, the liquid level in the cartridge S2 can be detected with high accuracy even if it is of a reflective type. The reason why the liquid level sensor 31 can be brought into contact with the side surface of the cartridge S2 is that the connection mechanism 2 is accurately positioned in the lateral direction by the positioning structure 4 . In this way, the position of the liquid level sensor 31 is fixed by the sensor holder 3, and the position of the cartridge S2 and the suction terminal 22 and the position of the side surface of the cartridge S2 and the liquid level sensor 13 are substantially fixed by the connection mechanism 2. Therefore, the height of the liquid level detected by the liquid level sensor 31 can also be kept at a substantially constant point from the tip of the cartridge S2. Until the liquid level is detected by the liquid level sensor 31, the pump continues to suck the sample liquid from the bottle S1 into the cartridge S2. Therefore, when the suction by the pump is finished, a predetermined amount of the sample liquid remains on the filter F in the cartridge S2.

The height of the sensor holder 3 or the liquid level sensor 31 with respect to the mounting surface 11 may be changed so that the amount of the sample liquid left in the cartridge S2 when the filtration is completed can be adjusted appropriately. . For example, the sensor holder 3 may be configured such that the height of the liquid level sensor 31 can be changed stepwise to a plurality of predetermined heights.

According to the sample pretreatment apparatus 100 according to the first embodiment configured as described above, as shown in FIGS. Since it is attachable to and detachable from the main body 1 having the pump, the suction terminals 22 can be simultaneously subjected to ATP erasure treatment and sterilization treatment by autoclave treatment or the like. Therefore, it is possible to eliminate the possibility of contamination occurring when filtering the sample liquid during filtration.

In addition, since the connection mechanism 2 is attached and detached while the positioning table 25 is fixed to the terminal plate 21, the positional relationship between each attraction terminal 22 and the mounting surface 26 can be changed even by attachment and detachment work for autoclaving or the like. Hard to change. For this reason, errors are less likely to occur in the amount of the sample liquid weighed in the cartridge S2 after filtration, and the accuracy of the subsequent ATP measurement, rapid detection of microorganisms, etc. can be improved more than before. In addition, since a predetermined amount of liquid can be accurately left in the cartridge S2 only by the suction operation of the sample pretreatment device 100, the liquid amount is adjusted by adding a separate liquid for the subsequent measurement as in the conventional art. No need to. Therefore, the time required for pretreatment for measurement can be shortened, and the possibility of contamination due to the addition of liquid can be eliminated.

Furthermore, the suction terminal 22 and the cartridge S2 can be connected simply by inserting the cartridge S2 into the insertion hole 27 of the sample container S and placing the bottom surface of the bottle S1 on the mounting surface . Therefore, the positional accuracy of the suction terminal 22 and the cartridge S2 can be made high while the connecting work is simpler than the conventional one.

In addition, since the connection mechanism 2 is provided with a plurality of suction terminals 22, the suction operation can be performed simultaneously on multiple sample containers S, and the operation time can be shortened.

Another embodiment of the present invention will be described.

In the first embodiment, the connection mechanism is provided with a plurality of suction terminals, and is configured so that sample liquids contained in a plurality of sample containers can be filtered simultaneously. only the suction terminal may be provided.

The mounting surface on which the connection mechanism is attached is not limited to a horizontal surface, and may be configured as a vertical surface, for example. That is, the sample container may be attached along the horizontal direction instead of along the vertical direction.

In the first embodiment, the narrow cylindrical portion of the suction terminal is inserted into the tip of the cartridge, but this relationship may be reversed. That is, the tip of the cartridge may be inserted into the thin cylindrical portion. Further, as shown in the partially enlarged view of FIG. 8, the tip of the thin cylindrical portion 24 of the suction terminal 2 is fitted into the tip of the cartridge S2, and the tip of the thin cylindrical portion 24 is provided inside the cartridge S2. Filtration may be performed in a state of being in close contact with the filter F that is present. With such a structure, it is possible to prevent liquid pools from forming between the cartridge S2 and the thin cylindrical portion 24 . Since the filtration accuracy can be improved in this way, for example, if a puddle exists, ATP molecules are diffused through the filter F into the puddle after ATP is taken out from the microorganisms on the filter F during measurement, and the ATP concentration changes to the actual value. You can prevent it from becoming smaller than The structure for attaching the cartridge to the bottle is not limited to the screw structure described in the embodiment. For example, the cartridge may be fitted into a hole formed in the bottom surface of the bottle, or the bottle and the cartridge may be integrally molded with resin, and a breaking structure may be formed so that the boundary between them can be separated. may

In addition, parts of the various embodiments may be combined or modified without departing from the gist of the present invention.

According to the present invention, it is possible to provide a sample pretreatment apparatus capable of reducing the trouble of connection and improving the accuracy of the amount of sample liquid measured in the cartridge. In addition, by using such a sample pretreatment device, it is possible to further improve the accuracy of subsequent measurements such as ATP measurement and microorganism detection.

Claims (10)

A sample pretreatment device for filtering a sample liquid to filter and concentrate predetermined components through a filter,
A connecting mechanism for connecting between a sample container having a bottle in which a sample liquid is stored, a cylindrical cartridge having a base end attached to the bottle and having the filter inside, and a suction source. ,
The cartridge leaves a concentrated sample liquid on the filter after filtration,
The connection mechanism
a suction terminal that connects between the tip side of the cartridge and a suction source and that suctions the sample liquid in the sample container;
a mounting surface to which the bottle is mounted and which positions the cartridge in a predetermined position with respect to the suction terminal. 2. The sample preprocessor according to claim 1, further comprising a liquid level sensor that detects the liquid level of the sample liquid in said cartridge. The connection mechanism
a terminal plate provided with the suction terminal;
a positioning base fixed at a position spaced apart from the terminal plate by a predetermined distance and having the mounting surface formed thereon;
3. The sample pretreatment apparatus according to claim 1 , wherein said positioning base has an insertion hole for inserting said cartridge at a position facing said suction terminal. A body comprising the suction source and a mounting surface on which the connection mechanism is mounted;
4. The sample pretreatment apparatus according to any one of claims 1 to 3, wherein said connection mechanism is configured to be detachable from said mounting surface. a suction port that opens to the mounting surface and is connected to the suction source by a suction pipe;
a positioning structure provided between the connection mechanism and the main body for positioning the suction terminal so as to be connected to the suction port in a state where the connection mechanism is mounted on the mounting surface. The sample pretreatment device according to claim 4 . 6. The sample pretreatment apparatus according to any one of claims 1 to 5 , wherein the connection mechanism is made of a material having a heat resistant temperature that allows autoclaving. a reflective liquid level sensor that detects the liquid level of the sample liquid in the cartridge;
5. The sample pretreatment apparatus according to claim 4 , further comprising a sensor holder for fixing the liquid level sensor to the main body so that the liquid level sensor detects the liquid level at a position corresponding to a target liquid level. . wherein the connection mechanism comprises a plurality of suction terminals;
8. The sample pretreatment apparatus according to any one of claims 1 to 7 , wherein said sample container is connected to each of said suction terminals and said suction operation can be performed simultaneously. a saucer provided below the suction pipe for receiving a filtrate of the sample liquid leaking from the suction pipe;
6. The sample preprocessor according to claim 5 , further comprising a filtrate detection sensor for detecting whether or not filtrate is present in said receiving tray. a sample pretreatment device according to any one of claims 1 to 9 ;
and a sample analyzer for measuring the sample liquid concentrated by the sample pretreatment device.

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