JP4854830B2 - Skin external preparation with moist feeling - Google Patents
Skin external preparation with moist feeling Download PDFInfo
- Publication number
- JP4854830B2 JP4854830B2 JP34734499A JP34734499A JP4854830B2 JP 4854830 B2 JP4854830 B2 JP 4854830B2 JP 34734499 A JP34734499 A JP 34734499A JP 34734499 A JP34734499 A JP 34734499A JP 4854830 B2 JP4854830 B2 JP 4854830B2
- Authority
- JP
- Japan
- Prior art keywords
- skin
- weight
- external preparation
- salts
- acrylic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000002360 preparation method Methods 0.000 title claims description 48
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 34
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 32
- 150000003839 salts Chemical class 0.000 claims description 31
- 229920002125 Sokalan® Polymers 0.000 claims description 21
- 229920001577 copolymer Polymers 0.000 claims description 13
- 239000006097 ultraviolet radiation absorber Substances 0.000 claims description 6
- 239000006096 absorbing agent Substances 0.000 claims description 5
- 230000000699 topical effect Effects 0.000 claims description 5
- QURCVMIEKCOAJU-UHFFFAOYSA-N trans-isoferulic acid Natural products COC1=CC=C(C=CC(O)=O)C=C1O QURCVMIEKCOAJU-UHFFFAOYSA-N 0.000 claims description 4
- QBLFZIBJXUQVRF-UHFFFAOYSA-N (4-bromophenyl)boronic acid Chemical compound OB(O)C1=CC=C(Br)C=C1 QBLFZIBJXUQVRF-UHFFFAOYSA-N 0.000 claims description 2
- KSEBMYQBYZTDHS-HWKANZROSA-M (E)-Ferulic acid Natural products COC1=CC(\C=C\C([O-])=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-M 0.000 claims description 2
- QURCVMIEKCOAJU-HWKANZROSA-N Isoferulic acid Natural products COC1=CC=C(\C=C\C(O)=O)C=C1O QURCVMIEKCOAJU-HWKANZROSA-N 0.000 claims description 2
- 125000004432 carbon atom Chemical group C* 0.000 claims description 2
- KSEBMYQBYZTDHS-HWKANZROSA-N ferulic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-N 0.000 claims description 2
- 229940114124 ferulic acid Drugs 0.000 claims description 2
- KSEBMYQBYZTDHS-UHFFFAOYSA-N ferulic acid Natural products COC1=CC(C=CC(O)=O)=CC=C1O KSEBMYQBYZTDHS-UHFFFAOYSA-N 0.000 claims description 2
- 235000001785 ferulic acid Nutrition 0.000 claims description 2
- 125000001183 hydrocarbyl group Chemical group 0.000 claims description 2
- -1 alkali metal salts Chemical class 0.000 description 28
- 239000002537 cosmetic Substances 0.000 description 27
- 239000000686 essence Substances 0.000 description 21
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 18
- ATMLPEJAVWINOF-UHFFFAOYSA-N acrylic acid acrylic acid Chemical compound OC(=O)C=C.OC(=O)C=C ATMLPEJAVWINOF-UHFFFAOYSA-N 0.000 description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 13
- 239000000047 product Substances 0.000 description 8
- 230000037307 sensitive skin Effects 0.000 description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 7
- 239000000203 mixture Substances 0.000 description 7
- 239000002562 thickening agent Substances 0.000 description 7
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 6
- 206010012438 Dermatitis atopic Diseases 0.000 description 6
- 201000008937 atopic dermatitis Diseases 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 238000009472 formulation Methods 0.000 description 5
- 239000003921 oil Substances 0.000 description 5
- 150000005846 sugar alcohols Polymers 0.000 description 5
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 4
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 4
- 229910052783 alkali metal Inorganic materials 0.000 description 4
- 125000000217 alkyl group Chemical group 0.000 description 4
- 235000014113 dietary fatty acids Nutrition 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 239000000839 emulsion Substances 0.000 description 4
- 239000003925 fat Substances 0.000 description 4
- 239000000194 fatty acid Substances 0.000 description 4
- 229930195729 fatty acid Natural products 0.000 description 4
- 229910052700 potassium Inorganic materials 0.000 description 4
- 239000011591 potassium Substances 0.000 description 4
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 4
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 4
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical class NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 3
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical class OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical class CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 3
- 150000003863 ammonium salts Chemical class 0.000 description 3
- 125000000637 arginyl group Chemical class N[C@@H](CCCNC(N)=N)C(=O)* 0.000 description 3
- 229910052791 calcium Inorganic materials 0.000 description 3
- 239000011575 calcium Substances 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 150000002169 ethanolamines Chemical class 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- 230000001771 impaired effect Effects 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 229910052749 magnesium Inorganic materials 0.000 description 3
- 239000011777 magnesium Substances 0.000 description 3
- 230000003020 moisturizing effect Effects 0.000 description 3
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 3
- 235000019799 monosodium phosphate Nutrition 0.000 description 3
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 230000003750 conditioning effect Effects 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 239000000645 desinfectant Substances 0.000 description 2
- 229940105990 diglycerin Drugs 0.000 description 2
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 150000002780 morpholines Chemical class 0.000 description 2
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
- 150000002978 peroxides Chemical class 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- NCTHNHPAQAVBEB-WGCWOXMQSA-M sodium ferulate Chemical compound [Na+].COC1=CC(\C=C\C([O-])=O)=CC=C1O NCTHNHPAQAVBEB-WGCWOXMQSA-M 0.000 description 2
- DSGXMEGLIMXDNB-WGCWOXMQSA-M sodium;(e)-3-(3-hydroxy-4-methoxyphenyl)prop-2-enoate Chemical compound [Na+].COC1=CC=C(\C=C\C([O-])=O)C=C1O DSGXMEGLIMXDNB-WGCWOXMQSA-M 0.000 description 2
- 229940032094 squalane Drugs 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 description 1
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 description 1
- GECRRQVLQHRVNH-MRCUWXFGSA-N 2-octyldodecyl (z)-octadec-9-enoate Chemical compound CCCCCCCCCCC(CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC GECRRQVLQHRVNH-MRCUWXFGSA-N 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- ULUAUXLGCMPNKK-UHFFFAOYSA-N Sulfobutanedioic acid Chemical compound OC(=O)CC(C(O)=O)S(O)(=O)=O ULUAUXLGCMPNKK-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 150000005215 alkyl ethers Chemical class 0.000 description 1
- 239000002280 amphoteric surfactant Substances 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- BTFJIXJJCSYFAL-UHFFFAOYSA-N arachidyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 description 1
- 239000003849 aromatic solvent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 239000000337 buffer salt Substances 0.000 description 1
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 1
- 239000004203 carnauba wax Substances 0.000 description 1
- 235000013869 carnauba wax Nutrition 0.000 description 1
- 239000003093 cationic surfactant Substances 0.000 description 1
- 229960000541 cetyl alcohol Drugs 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000002826 coolant Substances 0.000 description 1
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 description 1
- 229960003957 dexamethasone Drugs 0.000 description 1
- 125000005131 dialkylammonium group Chemical group 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 238000005562 fading Methods 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000003349 gelling agent Substances 0.000 description 1
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 229940119170 jojoba wax Drugs 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000008099 melanin synthesis Effects 0.000 description 1
- 239000004200 microcrystalline wax Substances 0.000 description 1
- 235000019808 microcrystalline wax Nutrition 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 230000037311 normal skin Effects 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 235000014593 oils and fats Nutrition 0.000 description 1
- 229940049964 oleate Drugs 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 229940055577 oleyl alcohol Drugs 0.000 description 1
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 150000003017 phosphorus Chemical class 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000004800 psychological effect Effects 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 229940114926 stearate Drugs 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
Landscapes
- Cosmetics (AREA)
Description
【０００１】
【発明の属する技術分野】
本発明は、化粧料などの皮膚外用剤に関し、更に詳細には、敏感肌及び／又はアトピー性皮膚炎の人に好適な皮膚外用剤に関する。
【０００２】
【従来の技術】
化粧料などの皮膚外用剤は、肌を正常に保ち、みずみずしく手入れするために必要不可欠なものであるが、ストレスなどの負荷量が急激に増大してきた近年に於いては、これに起因して敏感肌の人が増えてきている。この様な人に於いては、例えば油脂などに由来する少量の過酸化物などが通常の人に比べて大きな影響を与えるため、正常肌の人にとっては有益な化粧料も、ごく少量存在する油脂由来の過酸化物のために刺激を感じて使用が出来ない場合が多く、この様な化粧料の開発が望まれている。現在のところこの様な人に好適な化粧料としては、本発明者らは保湿成分に注目し、油脂成分を含まない形態の、所謂、オイルフリー皮膚外用剤が有用であることを見出している。しかしながら、この様なオイルフリー形態の化粧料の課題としては、使用実感において、化粧料による手入れを行った印象が薄く、これによる化粧料の心理的効果に由来する整肌効果の低減の抑制が残っている。即ち、オイルフリー形態であり、使用実感に優れる化粧料などの皮膚外用剤の開発が望まれていた。
【０００３】
一方、アクリル酸・アクリル酸（Ｃ１０〜３０）アルキル及びその塩は、界面活性作用を有する増粘剤として、化粧料に使用されているし、カルボキシビニルポリマーの塩も増粘剤として化粧料などの皮膚外用剤に使用されているが、これらを組み合わせて皮膚外用剤に含有させることは行われていなかったし、この様な組合せをオイルフリー形態の化粧料等の皮膚外用剤に適用することも、それによってオイルフリー形態の皮膚外用剤の使用実感を著しく改善しうることも全く知られていなかった。更に、アクリル酸・アクリル酸（Ｃ１０〜３０）アルキル及びその塩のみを増粘剤として使用した場合には、安定性に問題が残る場合があり、カルボキシビニルポリマー及び／又は塩と組み合わせると安定性が向上しこの様な問題も解決しうることも全く知られていなかった。
【０００４】
【発明が解決しようとする課題】
本発明はこの様な状況下為されたものであり、使用実感に優れる、敏感肌の人やアトピー性皮膚炎の人にも使用可能な化粧料などの皮膚外用剤を提供することを課題とする。
【０００５】
【課題の解決手段】
本発明者らは、この様な状況に鑑みて、使用実感に優れる、敏感肌の人やアトピー性皮膚炎の人にも使用可能な化粧料などの皮膚外用剤を求めて鋭意研究を重ねた結果、アクリル酸・アクリル酸（Ｃ１０〜３０）アルキルコポリマー及び／又はその塩とカルボキシビニルポリマー及び／又はその塩とを含有することを特徴とする、皮膚外用剤が、オイルフリーの形態に於いても、使用実感にも、安定性にも優れる皮膚外用剤となることを見出し、発明を完成させるに至った。即ち、本発明は、アクリル酸・アクリル酸（Ｃ１０〜３０）アルキルコポリマー及び／又はその塩とカルボキシビニルポリマー及び／又はその塩とを含有することを特徴とする、皮膚外用剤を提供するものである。
【０００６】
【発明の実施の形態】
（１）本発明の必須の成分であるアクリル酸・アクリル酸（Ｃ１０〜３０）アルキルコポリマー及び／又はその塩
本発明の皮膚外用剤はアクリル酸・アクリル酸（Ｃ１０〜３０）アルキルコポリマー及び／又はその塩を必須成分として含有することを特徴とする。アクリル酸・アクリル酸（Ｃ１０〜３０）アルキルコポリマーは乳化作用を有する増粘剤として既に知られており、化粧料などの皮膚外用剤で既に使用されている。このアクリル酸・アクリル酸（Ｃ１０〜３０）アルキルコポリマーは既に市販されており、本発明の皮膚外用剤を作成する場合にはこの様な市販のものを利用することが出来る。この様な市販品としては、例えばグッドリッチ社から販売されているカーボポール１３８２等が好ましく例示できる。又、生理的に許容されるその塩としては、例えば、ナトリウム、カリウムなどのアルカリ金属塩、カルシウム、マグネシウムなどのアルカリ土類金属塩、アンモニウム塩、トリエタノールアミン塩やモノエタノールアミン塩、トリエチルアミン塩、モルフォリン塩等の有機アミン塩、リジン塩、アルギニン塩等の塩基性アミノ酸塩などが好ましく例示できる。これらの内、特に好ましい塩はアルカリ金属塩であり、中でもカリウム塩がその使用時の感触から特に好ましい。これらのアクリル酸・アクリル酸（Ｃ１０〜３０）アルキルコポリマー及び／又はその塩は唯１種を含有させることも出来るし、２種以上を組み合わせて含有させることも可能である。これらアクリル酸・アクリル酸（Ｃ１０〜３０）アルキルコポリマー及び／又はその塩は皮膚外用剤全量に対して０．０５〜５重量％、更に好ましくは、０．１〜１重量％の含有量が好ましい。これは、少なすぎると本発明の皮膚外用剤の特徴である使用実感が得られず、多すぎるとべたつくなどの好ましくない感触に感じる人が増えるためである。又、この含有量は後述するカルボキシビニルポリマー及び／又は塩の量とも関係しており、アクリル酸・アクリル酸（Ｃ１０〜３０）アルキルコポリマー及び／又はその塩とカルボキシビニルポリマー及び／又はその塩の重量比は２：１〜１５：１が好ましく、更に好ましくは３：１〜１０：１である。これは、アクリル酸・アクリル酸（Ｃ１０〜３０）アルキルコポリマー及び／又はその塩が多すぎると経時的な安定性が損なわれる場合があり、カルボキシビニルポリマー及び／又は塩が多すぎると使用実感が損なわれる場合があるからである。
【０００７】
（２）本発明の皮膚外用剤の必須成分であるカルボキシビニルポリマー及び／又はその塩本発明の皮膚外用剤は、カルボキシビニルポリマー及び／又はその塩を必須成分として含有することを特徴とする。カルボキシビニルポリマーは通常、化粧料や皮膚外用医薬の皮膚外用剤分野で使用されているものであれば特段の限定無く使用することが出来る。この様な原料としては市販品も多く適宜それらを選択すればよいが、これらの中で特に好ましいものは、製造工程において芳香族系溶剤を使用しないグッドリッチ社のカーボポールＵｌｔｒｅｚ１０である。これは製造工程上環境に好ましいからである。又、これらカルボキシビニルポリマーの塩としては、例えば、ナトリウム、カリウムなどのアルカリ金属塩、カルシウム、マグネシウムなどのアルカリ土類金属塩、アンモニウム塩、トリエタノールアミン塩やモノエタノールアミン塩、トリエチルアミン塩、モルフォリン塩等の有機アミン塩、リジン塩、アルギニン塩等の塩基性アミノ酸塩などが好ましく例示できる。本発明では、これらカルボキシビニルポリマー及び／又はその塩を唯１種用いることも出来るし、２種以上組み合わせて用いることも出来る。これらのカルボキシビニルポリマー及び／又はその塩の好ましい含有量は、上記のアクリル酸・アクリル酸（Ｃ１０〜３０）アルキルとの量比を維持する範囲に於いて、０．０１〜１重量％が好ましく、更に、０．０５〜０．５重量％が更に好ましい。これは、カルボキシビニルポリマー及び／又はその塩が多すぎると使用実感を損なうことがあり、少なすぎると安定性に寄与しなくなる場合があるからである。
【０００８】
（３）本発明の皮膚外用剤
本発明の皮膚外用剤は上記２種の必須成分を含有することを特徴とする。尚、本発明で言う皮膚外用剤とは、皮膚上に外用で適用する組成物の総称であり、例えば、皮膚外用医薬、化粧料、外用消毒剤、外用殺菌剤、外用冷却剤などが例示でき、これらの中では、皮膚外用医薬と化粧料に適用するのが特に好ましい。又、この様な皮膚外用剤の適用範囲に於いては、安全性が高く、保湿成分を補え、しっかりした使用実感を提供できる本発明の皮膚外用剤の特質から、アトピー性皮膚炎の人や敏感肌の人向けの皮膚外用剤とすることが特に好ましい。本発明の皮膚外用剤に於いては、上記必須の成分以外に、本発明の効果を損なわない範囲に於いて、通常皮膚外用医薬や化粧料で使用されている任意成分を含有することが出来る。この様な任意成分としては、例えば、スクワラン、ワセリン、マイクロクリスタリンワックス等の炭化水素類、ホホバ油、カルナウバワックス、オレイン酸オクチルドデシル等のエステル類、ステアリン酸、オレイン酸、リチノレイン酸等の脂肪酸、オレイルアルコール、ステアリルアルコール、オクチルドデカノール等の高級アルコール、スルホコハク酸エステルやポリオキシエチレンアルキル硫酸ナトリウム等のアニオン界面活性剤類、アルキルベタイン塩等の両性界面活性剤類、ジアルキルアンモニウム塩等のカチオン界面活性剤類、ソルビタン脂肪酸エステル、脂肪酸モノグリセライド、これらのポリオキシエチレン付加物、ポリオキシエチレンアルキルエーテル、ポリオキシエチレン脂肪酸エステル等の非イオン界面活性剤類、ポリエチレングリコール、グリセリン、１，３−ブタンジオール等の多価アルコール類、増粘・ゲル化剤、酸化防止剤、紫外線吸収剤、色剤、防腐剤、粉体等を含有することができる。これらの内、特に好ましいものは、多価アルコール類である。これは、優れた保湿作用を有し、安全性が高く過酸化脂質を産生しないからである。又、多価アルコールとしては、１，３−ブタンジオール、１，２−ペンタンジオール、グリセリン、ジグリセリンが特に好ましい。これら多価アルコールの好ましい含有量は、皮膚外用剤全量に対し、３〜２０重量％であり、更に好ましくは５〜１５重量％である。又、本発明の過酸化脂質を産生させない目的から、油脂類、即ち、炭素数８以上の炭化水素基を側鎖として有する油溶性成分は含有しないオイルフリー形態の製剤が特に好ましい。又、緩衝塩を用いる場合には、クエン酸塩系を用いるよりも燐酸塩系を用いる方が好ましい。これは減粘や退色等に影響が少ないからである。更に、系の安定性を著しく高める効果があることから紫外線吸収剤、取り分け水溶性の紫外線吸収剤を含有することも特に好ましい。かかる水溶性紫外線吸収剤としては、例えば、フェルラ酸、イソフェルラ酸、スリソベンゾン及び生理的に許容されるその塩から選ばれる１種乃至は２種以上が好ましく例示でき、その塩としては、例えば、ナトリウム、カリウムなどのアルカリ金属塩、カルシウム、マグネシウムなどのアルカリ土類金属塩、アンモニウム塩、トリエタノールアミン塩やモノエタノールアミン塩、トリエチルアミン塩、モルフォリン塩等の有機アミン塩、リジン塩、アルギニン塩等の塩基性アミノ酸塩などが好ましく例示できる。これらの中で最も好ましいものはイソフェルラ酸ナトリウムである。これら紫外線吸収剤の好ましい含有量は、０．０１〜３重量％であり、更に好ましくは０．０５〜１重量％である。これら紫外線吸収剤は紫外線吸収作用以外の効果を有することがあり、その様な目的で前記紫外線吸収剤を含有させる場合があるが、この様な場合に於いても、アクリル酸・アクリル酸（Ｃ１０〜３０）アルキルコポリマー及び／又はその塩並びにカルボキシビニルポリマー及び／又はその塩の共存下で使用する場合には、本発明の皮膚外用剤の要件を構成し、本発明の技術的範囲に属する。かかる紫外線吸収剤の二次的な用途しては、例えば、メラニン産生抑制剤、抗酸化剤、保湿剤などが例示できる。本発明の皮膚外用剤は、上記成分を常法に従って処理することによって製造することが出来、かくして得られた本発明の皮膚外用剤は、例えば、化粧水或いはエッセンスのようなオイルフリーの形態であっても、その使用感に於いては、乳液のようなしっとりとした感触を有し、使用することによってその使用感を実感し、以て皮膚外用剤の持っている効果を効果的に作用させることが出来る。この為、脂質過酸化物に対して敏感な敏感肌の人或いはアトピー性皮膚炎の人であっても、刺激を感じる可能性が極めて低く、従来の化粧に比べて好適に用いることが出来る。又、安定性についても、アクリル酸・アクリル酸（Ｃ１０〜３０）アルキルコポリマー単独使用に比べて著しく向上している。
【０００９】
【実施例】
以下に実施例を挙げて、本発明について更に詳細に説明を加えるが、本発明が、これら実施例にのみ限定を受けないことは言うまでもない。
【００１０】
＜対照例３及び実施例２〜３＞下記に示す処方に従って、オイルフリー形態のエッセンス（化粧料）を作成した。即ち、イ、ロを７０℃に加熱し、減圧下攪拌可溶化してイに徐々にロを加え攪拌冷却し、ゲル状エッセンスを得た。尚、カルボキシビニルポリマーとしては、カーボポールULTREZ10（Ｕ１０）をアクリル酸・アクリル酸（Ｃ１０〜３０）アルキルとしてはカーボポール１３８２（１３８２）を用いた。又、この本発明の皮膚外用剤であるエッセンスについて、日光照射３０分に於ける粘度変化（粘度の単位は１００ｍＰａ・ｓ）を測定した。対照例１としては増粘剤をＵ１０のみとしたもの、対照例２としては、増粘剤を１３８２のみとしたものを用いた。結果を表１に示す。これより、本発明の皮膚外用剤は安定性に優れることがわかる。又、任意成分として紫外線吸収剤を含有することが好ましいこともわかる。
（表１中ＩＦＮはイソフェルラ酸ナトリウムを表す。）
イ
増粘剤＊ ０．５ 重量部
成分１＊ ０．０１重量部
水 ５０ 重量部
ロ
水酸化カリウム ０．２ 重量部
水 ４９．２９重量部
＊詳細は表１に示す。
【００１１】
【表１】
＜実施例４＞
実施例１〜３のエッセンス、対照例１，２及び下記に処方を示す比較例１の乳液について、専門パネラー５名を用いて目隠しテストを行った。即ち、各パネラーに目隠しをし、これらの化粧料を使用してもらい、クリームか乳液かジェル状のエッセンスかを判定してもらった。結果を表２に示す。本発明の皮膚外用剤であるエッセンスはクリーム乃至は乳液のような油分を含有する剤形の使用感を有していることがわかる。即ち、本発明の化粧料を使用することによって使用時に於ける化粧実感を味わうことが出来ることがわかる。
（比較例１）
スクワラン ５ 重量部
セタノール ３ 重量部
バチルワックス １ 重量部
ポリオキシエチレンステアリン酸エステル １ 重量部
Ｕ１０ ０．３重量部
水酸化カリウム ０．１重量部
１，３−ブタンジオール ５ 重量部
水 ８４．６重量部
【００１３】
【表２】
＜実施例５＞
下記に示す処方に従って、本発明の皮膚外用剤であるエッセンス（化粧料）を作成した。即ち、イ、ロの成分を７０℃に加温し、減圧下混合、攪拌冷却し、エッセンスを得た。このものを実施例３のエッセンスを対照に使用感を専門パネラーに評価してもらったところ、実施例３よりもしっとり感があり、優れた使用実感を有していると判定された。このものを敏感肌の人７名に２週間、発疹や炎症などの肌トラブルが起こらない範囲に於いて、３週間連日使用してもらったが、７名とも肌トラブルは認められず、優れた整肌効果が観察された。これは、オイルフリー形態であることと使用実感に優れるためであると推測された。又、本発明の皮膚外用剤には多価アルコールを含有させることが好ましいこともわかる。
イ
１３８２ ０．４重量部
Ｕ１０ ０．１重量部
ＩＦＮ ０．０１重量部
１，３−ブタンジオール １０ 重量部
水 ４０ 重量部
ロ
水酸化カリウム ０．２重量部
水 ４９．２９重量部
【００１５】
＜実施例６＞
下記に示す処方に従って、本発明の皮膚外用剤であるエッセンス（化粧料）を作成した。即ち、イ、ロの成分を７０℃に加温し、減圧下混合、攪拌冷却し、エッセンスを得た。このものを実施例３のエッセンスを対照に使用感を専門パネラーに評価してもらったところ、実施例３よりもしっとり感があり、優れた使用実感を有していると判定された。
イ
１３８２ ０．４重量部
Ｕ１０ ０．１重量部
フェルラ酸ナトリウム ０．０１重量部
１，２−ペンタンジオール １０ 重量部
燐酸２水素１ナトリウム ０．０１重量部
水 ４０ 重量部
ロ
水酸化カリウム ０．２重量部
水 ４９．２８重量部
【００１６】
＜実施例７＞
下記に示す処方に従って、本発明の皮膚外用剤であるエッセンス（化粧料）を作成した。即ち、イ、ロの成分を７０℃に加温し、減圧下混合、攪拌冷却し、エッセンスを得た。このものを実施例３のエッセンスを対照に使用感を専門パネラーに評価してもらったところ、実施例３よりもしっとり感があり、優れた使用実感を有していると判定された。
イ
１３８２ ０．４重量部
Ｕ１０ ０．１重量部
スリソベンゾンナトリウム ０．０１重量部
グリセリン １０ 重量部
燐酸２水素１ナトリウム ０．０１重量部
水 ４０ 重量部
ロ
水酸化カリウム ０．２重量部
水 ４９．２８重量部
【００１７】
＜実施例８＞
下記に示す処方に従って、本発明の皮膚外用剤であるエッセンス（化粧料）を作成した。即ち、イ、ロの成分を７０℃に加温し、減圧下混合、攪拌冷却し、エッセンスを得た。このものを実施例３のエッセンスを対照に使用感を専門パネラーに評価してもらったところ、実施例３よりもしっとり感があり、優れた使用実感を有していると判定された。
イ
１３８２ ０．４重量部
Ｕ１０ ０．１重量部
ジグリセリン ０．０１重量部
１，２−ペンタンジオール １０ 重量部
燐酸２水素１ナトリウム ０．０１重量部
水 ４０ 重量部
ロ
水酸化カリウム ０．２重量部
水 ４９．２８重量部
【００１８】
＜実施例９＞
下記に示す処方に従って、本発明の皮膚外用剤であるエッセンス（皮膚外用医薬）を作成した。即ち、イ、ロの成分を７０℃に加温し、減圧下混合、攪拌冷却し、エッセンスを得た。このものは有効成分以外に油脂類を含んでいなかったので、アトピー性皮膚炎の人の炎症を抑えるのに極めて好適であった。
イ
１３８２ ０．４重量部
Ｕ１０ ０．１重量部
フェルラ酸ナトリウム ０．０１重量部
プロピレングリコール １０ 重量部
デキサメタゾン １ 重量部
燐酸２水素１ナトリウム ０．０１重量部
水 ４０ 重量部
ロ
水酸化カリウム ０．２重量部
水 ４８．２８重量部
【００１９】
【発明の効果】
本発明によれば、使用実感に優れる、敏感肌の人やアトピー性皮膚炎の人にも使用可能な化粧料などの皮膚外用剤を提供することが出来る。[0001]
BACKGROUND OF THE INVENTION
The present invention relates to a skin external preparation such as cosmetics, and more particularly to a skin external preparation suitable for a person with sensitive skin and / or atopic dermatitis.
[0002]
[Prior art]
External preparations for skin such as cosmetics are indispensable for keeping the skin healthy and fresh, but in recent years when the amount of stress and other loads has increased rapidly, The number of people with sensitive skin is increasing. In such people, for example, small amounts of peroxides derived from oils and fats have a greater effect than normal people, so there are very small amounts of cosmetics that are beneficial for people with normal skin. In many cases, it cannot be used due to irritation due to the peroxide derived from fats and oils, and development of such cosmetics is desired. At present, as cosmetics suitable for such people, the present inventors have focused on moisturizing ingredients and found that so-called oil-free skin external preparations that do not contain oil and fat ingredients are useful. . However, the problem of such oil-free cosmetics is that the impression of having been cared for with cosmetics is thin in terms of actual use, and this suppresses the reduction of the skin conditioning effect derived from the psychological effects of cosmetics. Remaining. That is, it has been desired to develop a skin external preparation such as a cosmetic that is oil-free and excellent in use feeling.
[0003]
On the other hand, acrylic acid / acrylic acid (C10-30) alkyl and its salt are used in cosmetics as a thickener having a surface active action, and salts of carboxyvinyl polymer are also used as a thickener in cosmetics, etc. However, the combination of these has not been included in the topical skin preparation, and such a combination should be applied to a topical skin preparation such as oil-free cosmetics. However, it has not been known at all that the use feeling of the oil-free external preparation for the skin can be remarkably improved. Furthermore, when only acrylic acid / acrylic acid (C10-30) alkyl and salts thereof are used as thickeners, there may be problems with stability, and stability when combined with carboxyvinyl polymer and / or salt. It has not been known at all that this problem can be improved and such problems can be solved.
[0004]
[Problems to be solved by the invention]
The present invention has been made under such circumstances, and it is an object of the present invention to provide a skin external preparation such as cosmetics that is excellent in use feeling and can be used for people with sensitive skin and atopic dermatitis. To do.
[0005]
[Means for solving problems]
In view of such a situation, the present inventors have intensively researched for external preparations for skin such as cosmetics that are excellent in use feeling and can be used for people with sensitive skin and atopic dermatitis. As a result, an external preparation for skin comprising an acrylic acid / acrylic acid (C10-30) alkyl copolymer and / or a salt thereof and a carboxyvinyl polymer and / or a salt thereof in an oil-free form. In addition, the present inventors have found that it is a skin external preparation excellent in use feeling and stability, and has completed the invention. That is, the present invention provides a skin external preparation characterized by containing an acrylic acid / acrylic acid (C10-30) alkyl copolymer and / or a salt thereof and a carboxyvinyl polymer and / or a salt thereof. is there.
[0006]
DETAILED DESCRIPTION OF THE INVENTION
(1) Acrylic acid / acrylic acid (C10-30) alkyl copolymer and / or salt thereof which is an essential component of the present invention The skin external preparation of the present invention is acrylic acid / acrylic acid (C10-30) alkyl copolymer and / or The salt is contained as an essential component. Acrylic acid / acrylic acid (C10-30) alkyl copolymers are already known as thickeners having an emulsifying action, and are already used in skin preparations such as cosmetics. This acrylic acid / acrylic acid (C10-30) alkyl copolymer is already on the market, and such a commercially available product can be used in preparing the skin external preparation of the present invention. As such a commercially available product, for example, Carbopol 1382 sold by Goodrich, etc. can be preferably exemplified. Examples of physiologically acceptable salts thereof include alkali metal salts such as sodium and potassium, alkaline earth metal salts such as calcium and magnesium, ammonium salts, triethanolamine salts, monoethanolamine salts, and triethylamine salts. Preferred examples include organic amine salts such as morpholine salts, and basic amino acid salts such as lysine salts and arginine salts. Among these, a particularly preferable salt is an alkali metal salt, and among them, a potassium salt is particularly preferable in terms of the feeling during use. These acrylic acid / acrylic acid (C10-30) alkyl copolymers and / or salts thereof may contain only one kind, or may contain two or more kinds in combination. These acrylic acid / acrylic acid (C10-30) alkyl copolymers and / or salts thereof have a content of 0.05 to 5% by weight, more preferably 0.1 to 1% by weight, based on the total amount of the external preparation for skin. . This is because if the amount is too small, the feeling of use that is a feature of the external preparation for skin of the present invention cannot be obtained, and if it is too large, the number of people who feel an unpleasant feeling such as stickiness increases. This content is also related to the amount of carboxyvinyl polymer and / or salt described later, and is an acrylic acid / acrylic acid (C10-30) alkyl copolymer and / or salt thereof and carboxyvinyl polymer and / or salt thereof. The weight ratio is preferably 2: 1 to 15: 1, more preferably 3: 1 to 10: 1. This is because if the amount of acrylic acid / acrylic acid (C10-30) alkyl copolymer and / or salt thereof is too much, the stability over time may be impaired, and if there is too much carboxyvinyl polymer and / or salt, the actual feeling of use may be. This is because it may be damaged.
[0007]
(2) a carboxyvinyl polymer and / or skin external preparation of the Shiohon invention is an essential component of the skin external preparation of the present invention is characterized in that it contains as carboxyvinyl polymer and / or an essential component a salt thereof. The carboxyvinyl polymer can be used without particular limitation as long as it is used in the field of skin external preparations of cosmetics and skin external medicines. As such a raw material, there are many commercially available products, and these may be selected as appropriate. Among them, a particularly preferable one is Carbopol Ultrez 10 manufactured by Goodrich which does not use an aromatic solvent in the production process. This is because it is preferable for the environment in the manufacturing process. Examples of salts of these carboxyvinyl polymers include alkali metal salts such as sodium and potassium, alkaline earth metal salts such as calcium and magnesium, ammonium salts, triethanolamine salts, monoethanolamine salts, triethylamine salts, Preferred examples include organic amine salts such as phosphorus salts, and basic amino acid salts such as lysine salts and arginine salts. In the present invention, it is possible to use these carboxyvinyl polymers and / or only one of its salts, can also be used in combination of two or more. The preferred content of these carboxyvinyl polymers and / or a salt thereof, in the range of maintaining the quantity ratio between the acrylic acid-acrylic acid (C10-30) alkyl, preferably 0.01 to 1 wt% Furthermore, 0.05 to 0.5% by weight is more preferable. This is because if the carboxyvinyl polymer and / or its salt is too much, the actual feeling of use may be impaired, and if it is too little, it may not contribute to the stability.
[0008]
(3) External preparation for skin of the present invention The external preparation for skin of the present invention is characterized by containing the above-mentioned two essential components. The skin external preparation referred to in the present invention is a general term for a composition to be applied externally on the skin, and examples thereof include skin external medicine, cosmetics, external disinfectant, external disinfectant, and external coolant. Among these, it is particularly preferable to apply the medicine to external skin medicine and cosmetics. In addition, in the application range of such external preparations for skin, the characteristics of the external preparation for skin according to the present invention, which is high in safety, supplements moisturizing ingredients, and can provide a firm feeling of use. It is particularly preferable to prepare a topical skin preparation for people with sensitive skin. The external preparation for skin of the present invention can contain, in addition to the above essential components, optional components that are usually used in external preparations for skin and cosmetics, as long as the effects of the present invention are not impaired. . Examples of such optional components, for example, squalane, vaseline, hydrocarbons such as microcrystalline wax, jojoba oil, carnauba wax, esters such as octyldodecyl oleate, stearate, oleate, etc. Richinorein acid Fatty acids, oleyl alcohol, stearyl alcohol, higher alcohols such as octyldodecanol, anionic surfactants such as sulfosuccinate and polyoxyethylene alkyl sodium sulfate, amphoteric surfactants such as alkylbetaine salts, dialkylammonium salts, etc. Nonionic surfactants such as cationic surfactants, sorbitan fatty acid esters, fatty acid monoglycerides, polyoxyethylene adducts thereof, polyoxyethylene alkyl ethers, polyoxyethylene fatty acid esters, Ethylene glycol, glycerol, 1,3 polyhydric alcohols such as butanediol, thickening-gelling agents, antioxidants, ultraviolet absorbers, may contain coloring material, preservatives, powders and the like. Of these, polyhydric alcohols are particularly preferred. This is because it has an excellent moisturizing action, is highly safe and does not produce lipid peroxide. As the polyhydric alcohol, 1,3-butanediol, 1,2-pentanediol, glycerin, and diglycerin are particularly preferable. The preferred content of these polyhydric alcohols is 3 to 20% by weight, more preferably 5 to 15% by weight, based on the total amount of the external preparation for skin. In addition, for the purpose of not producing the lipid peroxide of the present invention, an oil-free preparation containing no oil or fat, that is, an oil-soluble component having a hydrocarbon group having 8 or more carbon atoms as a side chain is particularly preferred. When using a buffer salt, it is preferable to use a phosphate system rather than a citrate system. This is because there is little influence on viscosity reduction or fading. Furthermore, it is particularly preferable to contain an ultraviolet absorber, particularly, a water-soluble ultraviolet absorber because it has the effect of significantly improving the stability of the system. As such a water-soluble ultraviolet absorber, for example, one or two or more kinds selected from ferulic acid, isoferulic acid, soribenzone and physiologically acceptable salts thereof can be preferably exemplified. Alkali metal salts such as potassium, alkaline earth metal salts such as calcium and magnesium, ammonium salts, organic amine salts such as triethanolamine salts, monoethanolamine salts, triethylamine salts, morpholine salts, lysine salts, arginine salts, etc. Preferred examples include basic amino acid salts of Of these, sodium isoferulate is most preferred. The preferable content of these ultraviolet absorbers is 0.01 to 3% by weight, and more preferably 0.05 to 1% by weight. These ultraviolet absorbers may have an effect other than the ultraviolet absorbing action, and the ultraviolet absorber may be contained for such purpose. In such a case, acrylic acid / acrylic acid (C10 -30) When used in the presence of an alkyl copolymer and / or a salt thereof and a carboxyvinyl polymer and / or a salt thereof, it constitutes a requirement for the external preparation for skin of the present invention and belongs to the technical scope of the present invention. Examples of secondary uses of such ultraviolet absorbers include melanin production inhibitors, antioxidants, and moisturizers. The skin external preparation of the present invention can be produced by treating the above components according to a conventional method, and the skin external preparation of the present invention thus obtained is in an oil-free form such as lotion or essence. Even if it is used, it has a moist feel like an emulsion, and when used, it feels the feeling of use and thus effectively exerts the effect of the external preparation for skin. It can be made. For this reason, even a person with sensitive skin or atopic dermatitis who is sensitive to lipid peroxide has a very low possibility of feeling irritation, and can be used suitably compared to conventional makeup. Further, the stability is remarkably improved as compared with the use of acrylic acid / acrylic acid (C10-30) alkyl copolymer alone.
[0009]
【Example】
Hereinafter, the present invention will be described in more detail with reference to examples, but it is needless to say that the present invention is not limited to these examples.
[0010]
< Control Example 3 and Examples 2 to 3 > Oil-free essences (cosmetics) were prepared according to the formulation shown below. That is, (a) and (b) were heated to 70 ° C., solubilized with stirring under reduced pressure, gradually added to (a) and cooled with stirring to obtain a gel essence. Carbopol ULPREZ10 (U10) was used as the carboxyvinyl polymer, and Carbopol 1382 (1382) was used as the acrylic acid / acrylic acid (C10-30) alkyl. Further, with respect to the essence as the external preparation for skin of the present invention, the change in viscosity (viscosity unit is 100 mPa · s) after 30 minutes of sunlight irradiation was measured. As the control example 1, the thickener was only U10, and as the control example 2, the thickener was only 1382. The results are shown in Table 1. This shows that the skin external preparation of this invention is excellent in stability. It can also be seen that it is preferable to contain an ultraviolet absorber as an optional component.
(In Table 1, IFN represents sodium isoferulate.)
A thickener * 0.5 parts by weight Component 1 * 0.01 parts by weight Water 50 parts by weight Potassium hydroxide 0.2 parts by weight Water 49.29 parts by weight * Details are shown in Table 1.
[0011]
[Table 1]
<Example 4>
About the essence of Examples 1-3, the comparative examples 1 and 2, and the emulsion of the comparative example 1 which shows a prescription below, the blind test was done using five expert panelists. That is, each panelist was blindfolded and asked to use these cosmetics to determine whether it was a cream, emulsion, or gel-like essence. The results are shown in Table 2. It turns out that the essence which is an external preparation for skin of this invention has the usability | use_condition of the dosage form containing oils like cream thru | or an emulsion. That is, it can be seen that the use of the cosmetic composition of the present invention allows the user to experience a feeling of makeup during use.
(Comparative Example 1)
Squalane 5 parts by weight cetanol 3 parts by weight batyl wax 1 part by weight polyoxyethylene stearate 1 part by weight U10 0.3 part by weight potassium hydroxide 0.1 part by weight 1,3-butanediol 5 parts by weight water 84.6 parts by weight Department [0013]
[Table 2]
<Example 5>
In accordance with the formulation shown below, an essence (cosmetic) that is an external preparation for skin of the present invention was prepared. That is, the components (a) and (b) were heated to 70 ° C., mixed under reduced pressure, and stirred and cooled to obtain an essence. When this product was evaluated by a specialized panelist using the essence of Example 3 as a contrast, it was determined that it had a moist feeling and a superior feeling of use than Example 3. 7 people with sensitive skin were used for 2 weeks for 3 weeks in a range where skin troubles such as rashes and inflammation did not occur. A skin conditioning effect was observed. This was presumed to be an oil-free form and excellent use feeling. It can also be seen that the topical skin preparation of the present invention preferably contains a polyhydric alcohol.
1382 0.4 parts by weight U10 0.1 parts by weight IFN 0.01 parts by weight 1,3-butanediol 10 parts by weight Water 40 parts by weight Potassium hydroxide 0.2 parts by weight Water 49.29 parts by weight
<Example 6>
In accordance with the formulation shown below, an essence (cosmetic) that is an external preparation for skin of the present invention was prepared. That is, the components (a) and (b) were heated to 70 ° C., mixed under reduced pressure, and stirred and cooled to obtain an essence. When this product was evaluated by a specialized panelist using the essence of Example 3 as a contrast, it was determined that it had a moist feeling and a superior feeling of use than Example 3.
1382 0.4 parts by weight U10 0.1 part by weight sodium ferulate 0.01 part by weight 1,2-pentanediol 10 parts by weight 1 sodium dihydrogen phosphate 0.01 part by weight water 40 parts by weight potassium hydroxide 0. 2 parts by weight water 49.28 parts by weight
<Example 7>
In accordance with the formulation shown below, an essence (cosmetic) that is an external preparation for skin of the present invention was prepared. That is, the components (a) and (b) were heated to 70 ° C., mixed under reduced pressure, and stirred and cooled to obtain an essence. When this product was evaluated by a specialized panelist using the essence of Example 3 as a contrast, it was determined that it had a moist feeling and a superior feeling of use than Example 3.
1382 0.4 part by weight U10 0.1 part by weight sodium soribenzone 0.01 part by weight glycerin 10 part by weight monosodium dihydrogen phosphate 0.01 part by weight water 40 part by weight potassium hydroxide 0.2 part by weight 49.28 parts by weight of water
<Example 8>
In accordance with the formulation shown below, an essence (cosmetic) that is an external preparation for skin of the present invention was prepared. That is, the components (a) and (b) were heated to 70 ° C., mixed under reduced pressure, and stirred and cooled to obtain an essence. When this product was evaluated by a specialized panelist using the essence of Example 3 as a contrast, it was determined that it had a moist feeling and a superior feeling of use than Example 3.
1382 0.4 parts by weight U10 0.1 part by weight diglycerin 0.01 part by weight 1,2-pentanediol 10 parts by weight dihydrogen monosodium phosphate 0.01 part by weight water 40 parts by weight potassium hydroxide 0.2 Parts by weight water 49.28 parts by weight
<Example 9>
In accordance with the prescription shown below, an essence (skin external preparation) of the present invention was prepared. That is, the components (a) and (b) were heated to 70 ° C., mixed under reduced pressure, and stirred and cooled to obtain an essence. Since this product did not contain fats and oils other than the active ingredient, it was extremely suitable for suppressing inflammation of a person with atopic dermatitis.
1382 0.4 parts by weight U10 0.1 part by weight sodium ferulate 0.01 part by weight propylene glycol 10 parts by weight dexamethasone 1 part by weight 1 sodium dihydrogen phosphate 0.01 part by weight water 40 parts by weight potassium borohydride 0. 2 parts by weight water 48.28 parts by weight
【The invention's effect】
ADVANTAGE OF THE INVENTION According to this invention, skin external preparations, such as cosmetics which are excellent also in use feeling and can be used also for the person of sensitive skin and the person of atopic dermatitis, can be provided.
Claims (2)
下記１）〜３）を満たすことを特徴とする皮膚外用剤。
１） a）とb）とが重量比が２：１〜１５：１である。
２） 炭素数８以上の炭化水素基を側鎖として有する油溶性成分を含有しない。
３） 水溶性の紫外線吸収剤を含有する。 a) an acrylic acid / acrylic acid (C10-30) alkyl copolymer and / or salt thereof, and b) a carboxyvinyl polymer and / or salt thereof,
A skin external preparation characterized by satisfying the following 1) to 3) .
1) The weight ratio of a) and b) is 2: 1 to 15: 1 .
2) Does not contain an oil-soluble component having a hydrocarbon group having 8 or more carbon atoms as a side chain.
3) Contains a water-soluble UV absorber.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP34734499A JP4854830B2 (en) | 1999-12-07 | 1999-12-07 | Skin external preparation with moist feeling |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP34734499A JP4854830B2 (en) | 1999-12-07 | 1999-12-07 | Skin external preparation with moist feeling |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2001163756A JP2001163756A (en) | 2001-06-19 |
| JP2001163756A5 JP2001163756A5 (en) | 2006-10-26 |
| JP4854830B2 true JP4854830B2 (en) | 2012-01-18 |
Family
ID=18389600
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP34734499A Expired - Lifetime JP4854830B2 (en) | 1999-12-07 | 1999-12-07 | Skin external preparation with moist feeling |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP4854830B2 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2898808B1 (en) * | 2006-03-27 | 2008-05-02 | Biotechmarine Soc Par Actions | "COSMETIC ACTIVE INGREDIENT COMPOSED OF ARGININE FERRULATE AND A MICROALGUE EXTRACT AND USES THEREOF". |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2533775B2 (en) * | 1987-05-14 | 1996-09-11 | ポーラ化成工業株式会社 | Topical skin |
| JP3661706B2 (en) * | 1993-10-28 | 2005-06-22 | 三省製薬株式会社 | Topical skin preparation |
| DE4426952C1 (en) * | 1994-07-29 | 1995-10-12 | Goldwell Gmbh | Anti-sun compsn. comprising separate oil and water phases |
| JP3493536B2 (en) * | 1995-09-12 | 2004-02-03 | 株式会社コーセー | Fluorinated oil-containing composition and oil-based cosmetic containing same |
| JP3437698B2 (en) * | 1995-12-26 | 2003-08-18 | 株式会社コーセー | Oily cosmetics |
| JP3853868B2 (en) * | 1996-03-23 | 2006-12-06 | 株式会社資生堂 | Oil-in-water emulsion composition |
| JPH10120521A (en) * | 1996-10-18 | 1998-05-12 | Shiseido Co Ltd | Translucent cosmetic |
| JP3940209B2 (en) * | 1996-11-14 | 2007-07-04 | 株式会社資生堂 | Solubilized cosmetics |
| JPH10265332A (en) * | 1997-03-26 | 1998-10-06 | Shiseido Co Ltd | Oil-in-water type emulsion composition |
| JPH10287524A (en) * | 1997-04-09 | 1998-10-27 | Shiseido Co Ltd | Solubilized cosmetic |
| JPH10298029A (en) * | 1997-04-28 | 1998-11-10 | Shiseido Co Ltd | Solubilized cosmetic |
| JP2000143479A (en) * | 1998-11-05 | 2000-05-23 | Kao Corp | Skin-bleaching cosmetic |
| JP2001031555A (en) * | 1999-07-23 | 2001-02-06 | Lion Corp | Preparation for external use for skin |
-
1999
- 1999-12-07 JP JP34734499A patent/JP4854830B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP2001163756A (en) | 2001-06-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR101420599B1 (en) | Compositions containing anti-acne agents and the use thereof | |
| JP5093998B2 (en) | Pigmentation preventing or improving agent | |
| HU230156B1 (en) | Agent containing fat oil, which contains onion extract, the production and use thereof for caring, preventing or treating damaged skin tissue, especially scarred tissue | |
| KR101508168B1 (en) | Keratotic plug regrowth inhibition agent, keratotic plug regrowth inhibition method, and keratotic plug regrowth inhibition kit | |
| JP2000119131A (en) | Emulsion containing hydrophilic thickening compound and thickening copolymer and composition containing the same emulsion and its use | |
| KR20160141297A (en) | Cosmetic composition for skin regeneration containing horse fat having an effect on skin elasticity and method for the manufacture thereof | |
| US7547434B2 (en) | Compositions and methods for mitigating skin irritation | |
| US20090023628A1 (en) | Cosmetic Composition and a Process for Preparing This Cosmetic Composition and a Cosmetic Product | |
| JP2007523137A (en) | Skin care composition containing salicylic acid | |
| US20030095991A1 (en) | Treatment for skin | |
| WO2002078651A1 (en) | Cosmetic composition with improved skin moisturizing properties | |
| JP2002161027A (en) | Method for suppressing inflammation and erythema and composition therefor | |
| JP2017193506A (en) | Skin Cosmetic | |
| JP2021088523A (en) | Skin cosmetics | |
| JP4854830B2 (en) | Skin external preparation with moist feeling | |
| TW202308591A (en) | Cosmetic | |
| JP2000109417A (en) | Cosmetic for improving somber color | |
| KR20220034071A (en) | Cosmetic composition for anti-aging | |
| JP3479048B2 (en) | Cosmetics and non-woven fabric impregnated cosmetics | |
| JPH07324027A (en) | Skin-beautifying cosmetic | |
| JP2019006693A (en) | Beautification method | |
| AU2019460289A1 (en) | Topical cosmetic composition, use of the cosmetic composition and mask for facial application | |
| JP2001019611A (en) | Skin composition for external use | |
| JPH11302147A (en) | Cosmetic | |
| JP3853773B2 (en) | Hair nourishing |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Written amendment |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20060907 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20060907 |
|
| RD03 | Notification of appointment of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7423 Effective date: 20060907 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20080218 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20090818 |
|
| A521 | Written amendment |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20091016 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20101026 |
|
| A521 | Written amendment |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20101217 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20111004 |
|
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20111026 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20171104 Year of fee payment: 6 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 4854830 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| EXPY | Cancellation because of completion of term |