JP4140127B2 - Blood coagulation analyzer - Google Patents

Description

[0001]
BACKGROUND OF THE INVENTION
The present invention relates to an analyzer for automatically analyzing a blood coagulation reaction in the field of clinical examination.
[0002]
[Prior art]
In order to measure the blood coagulation reaction, a specimen is placed in a cuvette, the cuvette is moved to a coagulation reaction measurement site (photometry port), and then a reagent is dispensed for measurement. In most blood coagulation reaction analyzers, the photometric port is equipped with a photometer that irradiates the cuvette with measurement light from a light source and detects scattered light or transmitted light from the sample reaction solution with a photodetector.
[0003]
In order to increase the processing capability of blood coagulation reaction analysis, there is also an analyzer in which a plurality of photometric ports are provided and the cells are sequentially transferred to the photometric port in units of the number of photometric ports to perform parallel processing.
Conventional blood coagulation analyzers usually have only one reagent dispensing mechanism, and in one cycle of operation, operations of cell supply, sample supply, one-time reagent dispensing and cell discharge are performed. A measurement program is created based on the included operation patterns.
[0004]
[Problems to be solved by the invention]
The measurement items for blood coagulation analysis include one that requires only one reagent dispensing (one reagent-based coagulation item) and one that requires twice (two-reagent-based coagulation item). For example, PT (prothrombin time), FIB (fibrinogen), and T · H (thrombotest hepaplastin test) may be dispensed with one reagent, while APTT (activated partial thromboplastin time) is dispensed with the first reagent in advance, After activating for a certain period of time, the triggering second reagent must be dispensed.
[0005]
Therefore, in a measurement program that includes two reagent coagulation items, in order to avoid the timing at which the reagent must be dispensed into two cells during one cycle, the second reagent coagulation item second reagent is dispensed at the timing. It was created by skipping the corresponding sample analysis, and the processing capacity was reduced.
Such a problem can be solved by providing two reagent dispensers, but since most measurement items of blood coagulation analysis are one reagent system, it is useless to provide two reagent dispensers.
[0006]
However, some blood coagulation analyzers are equipped with a scattering photometer that measures coagulation items and a colorimetric photometer that measures colorimetric items of the two-reagent system as photometric ports, depending on the selected measurement item. There are cases where there are many 1-reagent systems and cases where there are many 2-reagent systems.
Accordingly, an object of the present invention is to make it possible to select an operation pattern such as supply and disposal of cuvettes, sample dispensing, reagent dispensing, and the like, and to improve processing capability.
[0007]
[Means for Solving the Problems]
FIG. 1A is a block diagram showing the present invention, and FIG. 1B shows an analysis condition screen when selecting an analysis mode.
A standard mode storage unit 52 storing a standard mode operation pattern and a high speed mode storage unit 54 storing a high speed mode operation pattern are provided. The standard mode storage unit 52 and the high speed mode storage unit 54 are connected to the analysis mode selection unit 56, respectively. Connected to the analysis mode selection unit 56 are a control unit 58 for controlling the operation of the apparatus and an input unit 60 for selecting one of the analysis modes (A).
[0008]
That is, the present invention is a blood coagulation analyzer including a reaction unit that detachably holds a plurality of cells, a cell supply and discard mechanism, a sample dispenser, a reagent dispenser, and a control unit 58 that controls operations. The standard mode storage unit 52 in which an operation pattern including cell supply, sample supply, multiple reagent dispensing and cell discharge operations is stored in one cycle of the operation, and the cell A high-speed mode storage unit 54 in which an operation pattern including operations of supply, sample supply, one-time reagent dispensing and cell discharge is stored, and an input for selecting either the standard mode or the high-speed mode. Unit 60 and an analysis mode selection unit 56 that reads out an operation pattern from the standard mode storage unit 52 or the high-speed mode storage unit 54 based on the selection information of the input unit 60. Based on the operation pattern information from the part 56, to create a measurement program, a blood coagulation analyzer which is adapted to control the operation accordingly.
[0009]
When one of the standard mode and the high-speed mode is selected on the analysis condition screen shown in FIG. 1B, the selection information is sent to the analysis mode selection unit 56 by the input unit 60. Based on the selection information, the analysis mode selection unit 56 reads the operation pattern from the standard mode storage unit 52 or the high speed mode storage unit 54 and sends it to the control unit 58. The control unit 58 creates a measurement program according to the operation pattern and controls the operation.
[0010]
【Example】
FIG. 2 is a plan view showing a blood coagulation analyzer to which the present invention is applied.
In the cuvette reaction unit 1, a plurality of photometric ports 2 are arranged in a fan shape on an arc. The photometric port 2 is kept at 37 ° C., for example. As the photometric port 2, a scattering port for measuring the amount of scattered light and a colorimetric port for measuring the amount of transmitted light are provided. As shown in FIG. 3, the scattering port detachably holds a cuvette 34 into which a specimen and a reagent are dispensed one by one, and a light source 36 such as an LED that irradiates measurement light to the specimen in the cuvette 34. In order to detect the scattered light of the measurement light due to the sample liquid, a photodetector 38 such as a photodiode provided on the optical axis in a direction orthogonal to the incident direction of the measurement light is provided. The colorimetric port includes an optical fiber that guides light of a predetermined wavelength from a common light source to a cuvette in a plurality of colorimetric ports that measure the amount of transmitted light, a photodiode provided on the same optical axis as the incident direction of measurement light, etc. Photo detector.
[0011]
Returning to FIG. 2 and continuing the description, a cuvette transfer arm 4 and a reagent probe 6 that move along an arc in which the photometric ports 2 are arranged are provided. As shown in FIG. 4, the cuvette transfer arm 4 and the reagent probe 6 are arranged at a distance in the vertical direction, and rotate at different heights on the arc in which the photometric ports 2 are arranged with a common rotation center. It is provided as follows.
[0012]
The cuvette transfer arm 4 attaches a cuvette to each photometric port 2 of the cuvette reaction unit 1 and removes the cuvette from the photometric port 2. In addition to each photometric port 2, the cuvette transfer arm 4 includes a cuvette supply position A for receiving the cuvette from the cuvette supply unit 8, a cuvette disposal port 10 for discarding the cuvette, and an agitation port 12 for stirring the cuvette in which the sample and the reagent are dispensed. Each is driven so that it can move and stop. The cuvette transfer arm 4 takes out the cuvettes stored in the cuvette supply unit 8 one by one at the cuvette supply position A and transfers the cuvettes to any one of the photometric ports 2 for mounting, or the measurement of one of the photometric ports 2 is completed. The later cuvette is taken out and discarded in the cuvette disposal port 10.
[0013]
FIG. 5 is a schematic configuration diagram showing the cuvette supply unit, where (A) is a partially cutaway side view, (B) is a top view around the guide rail, and (C) is a cuvette arranged in the cuvette supply unit. The side view to represent, (D) is sectional drawing of the cuvette.
The cuvette 34 is a transparent plastic molded product, and the flange 34a at the opening of the cuvette 34 is formed with a size larger than that of the body portion 34b. A band-shaped crease (a portion where irregularities are formed on the surface and the transparency is lowered) 34c is formed around the body 34b on the side of the flange 34a. The wrinkle 34c is formed at a position that does not affect the measurement of the specimen.
The cuvette supply unit 8 is provided with a cuvette storage unit 40 that stores a plurality of such cuvettes 34 at random. Two cuvettes are arranged in the cuvette accommodating part 40 at a distance wider than the body part 34b of the cuvette 34 and narrower than the flange 34a. Due to the rotation of these rotating discs, the cuvettes 34 accommodated in the cuvette accommodating portion 40 are sequentially discharged from the cuvette outlet 42 with the opening portion facing upward.
[0014]
At the cuvette outlet 42, one end side of the two guide rails 44 is arranged at a distance wider than the body portion 34b of the cuvette 34 and narrower than the flange 34a. The guide rail 44 is disposed with an inclination in which one end side is high and the other end side is low, and the cuvette 34 supplied from the cuvette outlet 42 slides from one end side to the other end side. The cuvettes 34 are arranged in
[0015]
On the other end side of the guide rail 44, a cuvette slide 46 for receiving the cuvettes 34 that have slid the guide rails 44 and supplying the arranged cuvettes 34 to the cuvette supply position A one by one is provided.
On one end side of the guide rail 44, an LED 48 as a light source and a photodetector 50 that detects light from the LED 48 are disposed in a space where the cuvette 34 is arranged. The LED 48 and the light detector 50 are installed such that a crease 34 c of the cuvette 34 exists between the LED 48 and the light detector 50 when the cuvette 34 reaches one end of the guide rail 44.
[0016]
When the cuvette 34 is accommodated in the cuvette accommodating portion 40 and the cuvette supply is started, the LED 48 is turned on. When the cuvette 34 is not present between the LED 48 and the photodetector 50, the light of the LED 48 is detected by the photodetector 50. In response to the detection signal, the turntable in the cuvette accommodating portion 40 is rotated, and the cuvette 34 is supplied to the cuvette outlet 42. The cuvette 34 slides from one end side to the other end side of the guide rail 44 and is received by the cuvette slide 46.
[0017]
When the light of the LED 48 is detected by the photodetector 50, the supply of the cuvette 34 from the cuvette accommodating portion 40 is repeated, and the cuvettes 34 are sequentially arranged on the guide rail 44 from the other end side.
When the cuvette 34 arranged on the guide rail 44 stops at a position between the LED 48 and the light detector 50, the light emitted from the LED 48 to the light detector 50 side is blocked by the crease 34c of the cuvette 34, and the light of the LED 48 is emitted. Since it is no longer detected by the detector 50 or falls below a predetermined threshold level, the cuvette supply from the cuvette accommodating portion 40 is stopped in response to the change in the detection signal.
[0018]
Thereafter, when the cuvette 34 is supplied to the cuvette supply position A by the cuvette slide 46, the cuvettes 34 arranged on the guide rail 44 slide to the cuvette slide 46 side by the size of the ridge 34a. Then, since the cuvette 34 does not exist between the LED 48 and the light detector 50, the light of the LED 48 is detected by the light detector 50, and the cuvette supply from the cuvette accommodating portion 40 is resumed.
Since the claw 34c is formed at a position corresponding to the LED 48 and the photodetector 50 of the cuvette 34, the detection of the photodetector 50 is performed when the cuvette 34 is present between the LED 48 and the photodetector 50. The output is greatly different, threshold setting is facilitated, and malfunction can be eliminated.
[0019]
Returning to FIG. 2, the description will be continued. A plurality of reagents are arranged on the circumference of the disk-shaped reagent table 14. The reagent table 14 is rotated in a reciprocating direction by a drive mechanism not shown in the figure, and can be stopped. On the back side of the reagent table 14, a magnetic stirrer (not shown) that rotates the magnetic bar member by magnetism is disposed at a position corresponding to the bottom surface of the reagent container at a predetermined position. By putting the magnetic rod member in the reagent container, when the reagent container is transferred to the magnetic stirrer position, the reagent is stirred and the precipitation of the reagent can be suppressed.
[0020]
In addition to each photometric port 2, the reagent probe 6 is moved to the reagent suction positions B and C on the reagent table 14 and the cleaning port 16 for cleaning the nozzle of the reagent probe 6, and is driven so that it can be stopped.
A disc-shaped sample table 18 is provided on the outer periphery of the reagent table 14, and a plurality of samples are arranged on the circumference of the sample table 18. The sample table 18 can be rotated and stopped in a reciprocating direction separately from the reagent table 14 by a drive mechanism not shown in the figure.
Since the reagent table 14 and the sample table 18 are arranged concentrically with each other, a compact arrangement can be achieved.
[0021]
A sample probe 20 is provided in the vicinity of the sample table 18. The sample probe 20 aspirates the sample transferred to the sample suction position D of the sample table 18 and dispenses the sample to the cuvette at the cuvette supply position A. To do. In addition to the cuvette supply position A and the sample suction position D, the sample probe 20 has a cleaning port 22 for cleaning the nozzle of the sample probe 20, an emergency sample port 24, a buffer port 26, a diluent port 28, a detergent port 30, and an external sample port 32. It is driven so that it can move and stop.
The reagent table 14 and the sample table 18 are cooled to a predetermined temperature by a cooling mechanism (not shown) in order to prevent deterioration of the arranged sample and reagent. Since the photometric port is kept at 37 ° C., hot water is circulated through the nozzle of the reagent probe 6 to prevent the temperature change when the reagent is dispensed. When the reagent is dispensed, the reagent is set to a predetermined temperature or higher.
[0022]
As shown in FIG. 1, a control unit 58 is provided to control the operation of each unit. As an operation by the control unit 58, the standard mode stored in the standard mode storage unit 52 performs reagent dispensing twice in one cycle, and the reagent dispensing in one cycle stored in the high speed mode storage unit 54 is 1 And a high-speed mode for performing the rotation.
First, the standard mode will be described.
FIG. 6 shows operations by the cuvette transfer arm 4, the reagent probe 6, the sample probe 20, and the like in the standard mode, and one cycle is composed of 20 seconds. Each cycle is assigned with cuvette supply, sample dispensing, cuvette discharge, first reagent dispensing, stirring after first reagent dispensing, second reagent dispensing, and stirring after second reagent dispensing. Even if these operations are included, one cycle is included only once.
[0023]
A new cuvette is placed at the cuvette supply position A by the cuvette supply unit 8. In the sample table 18, the identification information of the sample is attached to the sample container by a barcode or the like, and the identification information of the sample container to be dispensed next is read by a barcode reader or the like to recognize the measurement item. Thereafter, the sample is transferred to the sample aspirating position D. After the sample probe 20 sucks a predetermined amount of buffer from the buffer port 26 or a predetermined amount of physiological saline from the diluent port 28, a predetermined amount of the sample at the sample suction position D is sucked, and the sample is buffered or physiological. It is dispensed into the cuvette at the cuvette supply position A together with the saline solution (inspection).
[0024]
The cuvette with the sample dispensed is transferred from the cuvette supply position A to the vacant photometric port 2 by the cuvette transfer arm 4. The cuvette is transferred to the agitation port 12 by the cuvette transfer arm 4 after a heat retention time of two cycles at the photometric port 2.
In the reagent table 14, the first reagent is transferred to the reagent suction position B or C. A predetermined amount of the first reagent at the reagent aspirating position B or C is aspirated by the reagent probe 6, and the first reagent is dispensed into the cuvette in which the specimen is dispensed, which is attached to the stirring port 12 (R1 minute). . Then, the sample and the first reagent are stirred by the stirring port 12. When the nozzle of the reagent probe 6 is lowered to dispense the first reagent, the operation of the cuvette transfer arm 4 is prohibited in order to prevent contact between the nozzle and the cuvette transfer arm 4.
After stirring, the cuvette dispensed with the first reagent is transferred from the stirring port 12 to the photometry port 2 by the cuvette transfer arm 4. The cuvette is transferred to the agitation port 12 by the cuvette transfer arm 4 after a first reaction time of 9 cycles at the photometric port 2 for reacting the specimen and the first reagent.
[0025]
In the reagent table 14, the second reagent is transferred to the reagent suction position B or C. A predetermined amount of the second reagent at the reagent aspirating position B or C is aspirated by the reagent probe 6, and the second reagent is dispensed into the cuvette attached to the stirring port 12 and dispensed with the sample and the first reagent. (R2 minutes). Then, the liquid stored in the cuvette is stirred by the stirring port 12. Even when the nozzle of the reagent probe 6 is lowered to dispense the second reagent, the operation of the cuvette transfer arm 4 is prohibited in order to prevent contact between the nozzle and the cuvette transfer arm 4.
After stirring, the cuvette in which the second reagent is dispensed is transferred from the stirring port 12 to the photometric port (colorimetric port) 2 by the cuvette transfer arm 4. The amount of transmitted light is measured after a second reaction time of about 14 cycles for reacting the product produced by the reaction between the specimen and the first reagent with the second reagent. The cuvette of the sample that has been measured is discarded to the cuvette disposal port 10 by the cuvette transfer arm 4 (discard).
[0026]
This operation is an operation in the case of measuring a colorimetric item that requires two types of reagents. For example, in the case of a two-reagent coagulation item that requires two types of reagents, such as APTT measurement, the second reagent is dispensed with the cuvette attached to the photometric port (scattering port) 2 and simultaneously with the second reagent dispensing. Start measurement of coagulation reaction process. In addition, in one-reagent coagulation items performed by dispensing only one type of reagent, such as PT measurement and Fib measurement, the reagent is dispensed with the cuvette attached to the photometric port (scattering port) 2, and reagent dispensing is performed. Coagulation reaction process measurement starts simultaneously with injection.
As described above, since the necessity of the stirring operation differs depending on the measurement item, when measuring a plurality of items for one specimen, it relates to the first reagent dispensing, the second reagent dispensing, or both shown in FIG. There is a cycle in which the cuvette transfer operation and the stirring operation are omitted.
[0027]
FIG. 7 shows a basic pattern (operation pattern) for each item in the standard mode. Here, a case where four items of colorimetric, APTT, PT, and Fib are measured for one specimen is shown.
The symbol “S” in FIG. 7 represents cuvette supply and sample dispensing, “R1” represents first reagent dispensing, “R2” represents second reagent dispensing, and “drain” represents cuvette dispensing.
PT and Fib perform the same operation. In PT and Fib, the sample is dispensed and the cuvette is supplied in the first cycle, and after keeping the temperature for two cycles, the first reagent (trigger reagent) is dispensed in the fourth cycle. After dispensing the trigger reagent, the scattered light amount measurement is started, and when blood coagulation is detected, the measurement is completed and the cuvette is discharged.
[0028]
Also in APTT, the sample is dispensed and the cuvette is supplied in the first cycle, and the first reagent is dispensed in the fourth cycle after the same heat retention time of two cycles. After dispensing the first reagent, after a certain time of 189 seconds for activation, the second reagent (trigger reagent) is dispensed at the 13th cycle, and the measurement of the amount of scattered light is started. The cuvette is discharged.
[0029]
In colorimetry, the sample is dispensed and the cuvette is supplied in the first cycle, and the first reagent is dispensed in the fourth cycle after the same heat retention time of two cycles. After the first reagent is dispensed, the second reagent is dispensed at the 13th cycle after a certain time of 189 seconds for the reaction between the specimen and the first reagent (first reaction). By the second reagent dispensing, the reaction between the product of the reaction between the sample and the first reagent and the second reagent (second reaction) is started, and the amount of transmitted light is measured up to the 27th cycle for 297 seconds. Thus, the measurement is performed by both the rate method and the endpoint method. The cuvette is then discharged.
In this way, four items are measured for one specimen.
[0030]
FIG. 8 shows how the photometric port is used in the standard mode. Here, a case where four items of colorimetric, APTT, PT, and Fib are measured for one specimen is shown. However, Fib is also shown as PT.
As shown in FIG. 7, in any item, the first reagent is dispensed after a predetermined time from the sample dispensing and cuvette supply (S) (R1). Thereafter, photometry or second reagent dispensing (R2) is performed according to the measurement item. In the case of colorimetry, the cuvette is attached to the colorimetric port after dispensing the second reagent. Here, in the colorimetry, the scattering port is used as the photometric port 2 for keeping the cuvette accommodation liquid before the second reagent dispensing, but a colorimetric port may be used.
According to this standard mode, 180 tests per hour, that is, four items including colorimetric items can be measured for 45 samples.
[0031]
Next, the high speed mode will be described.
FIG. 9 shows the operation of the cuvette transfer arm 4, the reagent probe 6, the sample probe 20, and the like in the high speed mode, and one cycle is composed of 12 seconds. Each cycle is assigned with cuvette supply, sample dispensing, cuvette discharge, and reagent dispensing operations. Even if these operations are included, only one cycle is included.
[0032]
In the same manner as in the standard mode, a new cuvette is placed at the cuvette supply position A, and the sample is dispensed with the buffer or saline (test) into the cuvette and transferred from the cuvette supply position A to the vacant photometric port 2 Is done.
In the reagent table 14, a predetermined reagent is transferred to the reagent suction position B or C. The reagent probe 6 sucks a predetermined amount of the reagent at the reagent suction position B or C, and dispenses the reagent into the cuvette attached to the photometry port 2 (R1 minute). The sample and the reagent are stirred by the momentum of the reagent ejected from the reagent probe. When the nozzle of the reagent probe 6 is lowered to dispense the reagent, the operation of the cuvette transfer arm 4 is prohibited in order to prevent contact between the nozzle and the cuvette transfer arm 4.
Coagulation reaction process measurement is started simultaneously with reagent dispensing. The cuvette of the sample that has been measured is discarded to the cuvette disposal port 10 by the cuvette transfer arm 4 (discard).
[0033]
This operation is an operation when measuring one reagent system coagulation item, for example, by dispensing only one kind of reagent, such as PT measurement and Fib measurement. For example, in a two-reagent coagulation item that requires two types of reagents, such as APTT measurement, the first reagent is first dispensed, and after a certain period of time has elapsed since the first reagent dispensing for activation, the second reagent The coagulation reaction process measurement is started simultaneously with the second reagent dispensing.
In this way, depending on the measurement item, two reagent dispensing operations are required for one cuvette. If such an item is included, the cuvette supply operation and sample distribution shown in FIG. 6 are performed. There is a cycle in which the pouring operation, the cuvette discarding operation, or all of these operations are omitted.
[0034]
FIG. 10 shows a basic pattern for each item in the high-speed mode. Here, a case where three items of APTT, PT, and Fib are measured for one specimen is shown. Here, description will be made assuming that the colorimetric items are not analyzed.
In FIG. 10, symbol “S” represents cuvette supply and sample dispensing, “R1” represents first reagent dispensing, “R2” represents second reagent dispensing, and “drain” represents cuvette dispensing.
PT and Fib perform the same operation. In PT and Fib, the sample is dispensed and the cuvette is supplied in the first cycle. After keeping the temperature for 4 cycles, the first reagent (trigger reagent) is dispensed in the 6th cycle. After dispensing the trigger reagent, the scattered light amount measurement is started, and when blood coagulation is detected, the measurement is completed and the cuvette is discharged.
[0035]
In APTT, the sample is dispensed and the cuvette is supplied in the first cycle, and the first reagent is dispensed in the sixth cycle after the same heat retention time of four cycles. After dispensing the first reagent, after a certain time of 192 seconds for activation, the second reagent (trigger reagent) is dispensed at the 22nd cycle, and the measurement of the amount of scattered light is started. The cuvette is discharged. Here, the blacked-out portion (17th cycle) indicates that if sample dispensing is performed in that cycle, the timing of the first reagent dispensing of the sample and APTT measurement with another sample is performed for the second reagent portion. This means that the cuvette supply and sample dispensing of the sample are shifted by one cycle when the injection timing may overlap in the same cycle. In this way, the timing is controlled so that the need for reagent dispensing twice in one cycle does not occur.
In this way, three items are measured for one specimen.
[0036]
FIG. 11 shows how the photometric port is used in the standard mode. Here, a case where three items of APTT, PT, and Fib are measured for one specimen is shown. However, Fib is also shown as PT.
As shown in FIG. 10, in any item, the first reagent is dispensed after a predetermined time from the sample dispensing and cuvette supply (S) (R1). Thereafter, photometry or second reagent dispensing (R2) is performed according to the measurement item. In the high-speed mode, since the colorimetric items are not analyzed, the colorimetric port is not used.
According to this high-speed mode, 225 tests per hour, that is, three items including two reagent-based coagulation items can be measured for 75 samples. In addition, when measuring only one reagent system coagulation item, a maximum of 300 tests can be performed.
[0037]
When any analysis mode is selected on the analysis condition screen shown in FIG. 1B, the selection information is sent to the analysis mode selection unit 56 by the input unit 60. Based on the selection information, the analysis mode selection unit 56 reads the operation pattern from the standard mode storage unit 52 or the high speed mode storage unit 54 and sends it to the control unit 58. The control unit 8 creates a measurement program as shown in FIG. 8 or FIG. 11 according to the operation pattern and measurement items, and controls the operation of each mechanism along the measurement program.
[0038]
In this embodiment, the cuvette transfer mechanism 4 and the reagent probe 6 are configured to move on the photometry port 2 arranged in a line in an arc shape, but the present invention is not limited to this, and photometry Whether the arrangement of the ports 2 is linear or matrix, the cuvette transfer mechanism 4 and the reagent probe 6 may move on the photometric port 2 at different heights.
In this embodiment, the sample table 18 is a turntable type, but may be a rack type. The reagent table 14 is also a turntable type, but a reagent container may be arranged on the locus of the reagent probe 6. In this embodiment, the reagent table 14 and the sample table 18 are rotated by separate drive mechanisms, but may be rotated and rotated simultaneously by the same drive mechanism.
[0039]
In addition, the reagent probe 4 may be provided with a function of dispensing the sample, and the sample probe 20 may not be installed.
In this embodiment, an operation pattern for performing the reagent dispensing operation twice in one cycle is set as the standard mode. However, the present invention is not limited to this, and the reagent is not less than three times in one cycle. An operation pattern for performing a dispensing operation may be set.
Further, in the high-speed mode of this embodiment, the description is limited to the solidification item, but it can be applied to the colorimetric item that does not require stirring.
[0040]
【The invention's effect】
In the present invention, in one cycle of operation, a standard mode storage unit in which an operation pattern including cell supply, sample supply, multiple reagent dispensing and cell discharge operations is stored; , Sample supply, one reagent dispensing and cell discharge including a high-speed mode storage unit storing an operation pattern, and an input for selecting either the standard mode or the high-speed mode A measurement program based on the operation pattern information from the analysis mode selection unit and the analysis mode selection unit that reads the operation pattern from the standard mode storage unit or the high-speed mode storage unit , And a control unit that performs control based on the operation pattern can be selected, and by inputting an appropriate analysis mode to the input unit according to the measurement item, Since control unit was set to create a measurement program based on the operation pattern stored in the standard mode storage unit or the high-speed mode storage unit, it is possible to increase processing power.
[Brief description of the drawings]
FIG. 1A is a block diagram illustrating the present invention, and FIG. 1B is a diagram illustrating an analysis condition screen when an analysis mode is selected.
FIG. 2 is a plan view showing a blood coagulation apparatus to which the present invention is applied.
FIG. 3 is a plan view showing a photometric port in the apparatus.
FIG. 4 is a side view showing a cuvette transfer arm and a reagent probe in the apparatus.
FIG. 5 is a schematic configuration diagram showing a cuvette supply unit, (A) is a partially cutaway side view, (B) is a top view around a guide rail, and (C) is a cuvette arranged in the cuvette supply unit. The side view to represent, (D) is sectional drawing of the cuvette.
FIG. 6 is a diagram illustrating an example of one cycle of operation in a standard mode.
FIG. 7 is a diagram illustrating an example of a basic pattern of measurement items in a standard mode.
FIG. 8 is a diagram illustrating a usage state of a photometry port in a standard mode.
FIG. 9 is a diagram illustrating an example of one cycle of operation in a high-speed mode.
FIG. 10 is a diagram illustrating an example of a basic pattern of measurement items in a high-speed mode.
FIG. 11 is a diagram illustrating a usage state of a photometry port in a high-speed mode.
[Explanation of symbols]
1 Cuvette reaction part
2 Metering port
4 Cuvette transfer arm
6 Reagent probe
8 Cuvette supply section
10 Cuvette disposal port
12 Stirring port
14,22 Reagent table
16 Washing port
18 Sample table
20 specimen probes
24 Emergency sample port
26 Buffer port
28 Diluent port
30 Detergent port
32 External sample port
34 cuvettes
40 cuvette compartment
44 Guide rail
46 cuvette slide
52 Standard mode memory
54 High-speed mode memory
56 Analysis mode selector
58 Control unit
60 Input section

Claims (1)

The reaction section having a plurality of ports for holding a cell detachably cell Le supply discard mechanism, the specimen dispensing device, in the blood coagulation analyzer which includes a control unit for controlling the reagent dispensing unit and operation,
The reagent dispensing unit comprises only one, the reagent dispenser is intended to dispense a reagent with only one reagent dispensing position,
The cell supply / discard mechanism, the sample dispenser, and the reagent dispenser are used as one cycle of operation for supplying the cell only once, supplying the sample only once to the cell, dispensing the reagent to the cell, and from the port. The cell is discharged only once.
And the standard mode storage unit operation pattern of the standard mode is stored reagent dispensing operation definitive one cycle of the operation is several times,
1 cycle time shorter than one cycle of the standard mode, the high-speed mode storage unit operation pattern of the high-speed mode is stored only reagent dispensing operation once the definitive one cycle of the operation,
An input unit in which one of the analysis modes of the standard mode or the high-speed mode is selected;
Based on the selection information of the input unit, comprising an analysis mode selection unit that reads an operation pattern from the standard mode storage unit or the high-speed mode storage unit,
The control unit, based on the operation pattern information from the analysis mode selection unit, creates a measurement program in which the operation sequences based on the respective operation patterns are arranged in order in the cycle of the standard mode or the high-speed mode for each cell , A blood coagulation analyzer that controls the operation based on it.

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