JP3766018B2 - Active oxygen scavenger - Google Patents

Description

[0001]
BACKGROUND OF THE INVENTION
  The present inventionBengal Karachi fruit, Bengal Karachi fruit peel, Bengal Karachi seed, Miracle berryContains one or more plant extracts selected fromActive oxygen scavengerIt is about.
[0002]
[Prior art]
  In recent years, the generation of active oxygen in vivo and various effects (diseases) caused thereby have been reported. In general, this active oxygen is also called Activated oxygens.^2-, H₂O₂,
· OH and chemiluminescence are roughly divided into four types, all of which have a strong bactericidal action and are regarded as important substances involved in the self-defense of living organisms, for example, bacteria, viruses, foreign bodies, etc. ) Enter the body, phagocytic cells, neutrophils, monocytes, and macrophages, start phagocytosis, and then dissolve phagocytic foreign bodies in the phagocytic vesicles. In addition to the production of active oxygen, this produced active oxygen not only dissolves sputum food, but also directly kills and protects against external enemies such as bacteria and foreign substances. Playing a role. In other words, it has the function of eliminating antigenic substances before the immune function is activated.
[0003]
  However, if this active oxygen for self-protection is excessively produced and secreted, even normal cells are lysed and stimulated, resulting in various disordered reactions. Recently, many diseases and illnesses induced by active oxygen have been reported. For example, fats and oils such as cholesterol in the blood are oxidized by active oxygen, and blood vessel damage (stroke, myocardial infarction, etc.) caused by arteriosclerosis in the brain and heart. It is said to cause blood flow disorder due to thrombus and the like, and ischemia in blood vessels due to rapid temporary atrophy during the brain trauma, resulting in an oxygen deficient state. Therefore, in this state, the xanthine dehydrogenase in the blood vessel is changed to xanthine oxidase, and a large amount of active oxygen is generated in the blood in the blood vessel, causing damage to the blood vessel wall and causing fatal damage. Yes.
[0004]
  As for the relationship between the skin and active oxygen, for example, since the skin is an organ that directly contacts the outside world, the active oxygen continues to be excessive in the skin due to ultraviolet rays, radiation, etc. while being susceptible to environmental factors. Then, it reacts with the unsaturated fatty acid of the biological membrane phospholipid and lipid peroxide is produced. The generated lipid peroxide causes arteriosclerosis, carcinogenesis, aging, membrane destruction, protein denaturation and the like, and also causes skin inflammation, edema, wrinkles and the like. Furthermore, as a disease caused by excess of active oxygen, from a cosmetic viewpoint, for example, herpes dermatitis, X-ray dermatitis, burns, trauma, solar dermatitis, contact dermatitis, eczema, atopic dermatitis, etc. Therefore, in order to prevent or ameliorate various diseases so far, for example, in the living body of animals and plants, superoxide is required. Dismutase (SOD), catalase, glutathioperoxidase, and others, tocopherol (vitamin E), oryzanol, plant extract (hamamelis, melissa, birch, birch, sage, rosemary, ages, basil, ginkgo, psycho, peonies, hanger, Keihi, Taiso, Ogon, carrot, licorice, ginger) etc. were used
[0005]
[Problems to be solved by the invention]
  However, the above-mentioned active oxygen scavenging substances are poor in stability and solubility in the formulation system, cause odor and coloration due to starch and decomposition, and are not sufficiently effective at the living body level. There was a problem in terms of safety, such as waking up, and it was not satisfactory.
[0006]
[Means for Solving the Problems]
  In view of such circumstances, the present inventors set the theme of development of a useful plant having an active oxygen scavenging (SOD) action, and as a result,Bengal Karachi fruit, Bengal Karachi fruit peel, Bengal Karachi seed, Miracle berryIt was confirmed that one or more plant extracts selected from the group significantly erased / suppressed active oxygen.
[0007]
DETAILED DESCRIPTION OF THE INVENTION
  As used herein, “Bengali Karatachi (aka: Vern.)” Refers to the fruits, pericarp, and seeds of Rutaceae and Bengal Karatachi (Aegle) plants: Bengal Karatachi “Aegle marmelos (L.) Correa”. In addition, the same species can also be used.
[0008]
  The “miracle fruit (also known as miracle berry)” used in the present invention is a plant belonging to the genus Sapotaceae or Synsepalum: miracle fruit “Synsepalum dulcificum D. (= Sideroxylon dulcificum A. DC.) Flowers, flower spikes, fruit spikes, pericarps, fruits, stems, leaves, branches, branches and leaves, stems, bark, rhizomes, root barks, roots, seeds or whole plants, but other congeneric species can also be used.
[0009]
  The “lemongrass” used in the present invention is a plant of Gramineae, CymbopogonAegle: Lemongrass “Cymbopogon citratus (DC.) Stapf (= C.flexuosus Stapf) stems and leaves Branches, branches and leaves or whole grasses are used, but other genera can also be used.
[0010]
  Used in the present inventionBengal Karachi, Miracle Berry, LemongrassExtract of various parts of each plant (flowers, flower ears, fruit ears, pericarp, fruits, stems, leaves, branches, branches and leaves, stems, bark, rhizomes, root barks, roots, tubers, rhizomes, corms, seeds Or whole plant etc.) or crushed after pulverization. Alternatively, it is extracted as it is or after pulverization with a solvent.
[0011]
  The extraction solvent for the above-mentioned various plant extracts may be selected in consideration of the intended purpose and type of the product to be provided, or the processing to be performed later. Usually, water, methanol, ethanol, propyl alcohol are used. Among various organic solvents such as lower alcohols such as isopropyl alcohol, butanol and isobutanol or water-containing lower alcohols, polyhydric alcohols such as propylene glycol, 1,3-butylene glycol and glycerin or water-containing polyhydric alcohols, acetone and ethyl acetate. It is desirable to use one or a mixture of two or more selected from However, when it is not preferable to contain an organic solvent depending on the purpose of use, only water may be used, or ethanol that is easy to remove after extraction may be used alone or in any mixture with water. , Exploited and extracted. Furthermore, it can be used in a state where each solvent extract is combined.
[0012]
  In addition to hydrolytic extraction of the above-mentioned various plants by enzymatic decomposition, those obtained by hydrolyzing with acid / alkali can also be used.
[0013]
  The production method is not particularly limited, but is usually within the range of the boiling point of the solvent at normal temperature and normal pressure. After extraction, filtration or ion exchange resin is used for adsorption, decolorization, and purification. A solution, paste, gel, or powder may be used. In many cases, it can be used as it is, but if necessary, further purification treatment such as deodorization and decoloration may be added as long as the effect is not affected. An activated carbon column or the like may be used, and usual means generally applied depending on the extracted substance may be arbitrarily selected. In addition, an organic solvent such as ethanol, propylene glycol, 1,3-butylene glycol, or any mixed solution thereof can be added to the extracted liquid after extraction. Although the obtained extract can be used as it is, it can be concentrated and dried to be used as a paste or powder.
[0014]
  Of the present inventionBengal Karachi fruit, Bengal Karachi fruit peel, Bengal Karachi seed, Miracle berryThe various plant extracts ofActive oxygen scavengerThe content is not particularly stipulated,Active oxygen scavengerDepending on the type, quality, and expected action level, it is usually 0.0001% by weight or more (hereinafter expressed as%) in terms of solid content in the total amount of the preparation, preferably 0.01 to 50.0. % Is good.
[0015]
  In addition, the present inventionActive oxygen scavengerThe dosage form and form are arbitrary, and can be used in the form of capsules, powders, granules, solids, liquids, gels, bubbles, emulsions, creams, ointments, sheets and the like.
[0016]
  The field of use can be used in various external preparations (including preparations used for animals) in general, specifically, ampoules, capsules, pills, tablets, powders, granules, solids, liquids, gels 1) Pharmaceuticals, 2) Quasi-drugs, 3) Topical or systemic skin cosmetics (for example, lotion, milky lotion) Basic cosmetics such as creams, ointments, lotions, oils, packs, facial cleansers and skin cleansers, massage agents, cleansing agents, hair removers, hair removers, shaving treatments, after-shave lotions, pre-show lotions, Makeup cosmetics such as shaving cream, foundation, lipstick, blusher, eye shadow, eyeliner, mascara, perfume, nail preparation, nail enamel, nail enamel Leavening agents, poultices, plasters, tapes, sheets, patches, aerosols, etc.), 4) medicinal and / or cosmetic preparations applied to the scalp and hair (eg shampoos, rinses, hairs) Treatment agents, pre-hair treatment agents, permanent liquids, hair dyes, hair styling agents, hair styling agents, hair growth and hair nourishing agents, poultices, plaster agents, tape agents, sheet agents, patch agents, aerosol agents, etc.), 5) bath water 6) Other anti-odor and deodorant agents, deodorants, antiperspirants, hygiene products, sanitary cotton, wet tissue, toothpastes, mouth fresheners, gargles, etc. .
[0017]
  In the present invention,Active oxygen scavengerCan be produced by optionally selecting and using any of the components and additives exemplified below within the range that does not impair the effects of the present invention, in addition to the essential components described above. The amount is not particularly limited, but usually 0.0001 to 50% is preferable.
[0018]
(1) Various fats and oils
  Avocado oil, almond oil, fennel oil, egoma oil, olive oil, orange oil, orange rafa oil, sesame oil, cacao butter, chamomile oil, carrot oil, cucumber oil, beef tallow fatty acid, kukui nut oil, safflower oil, shea butter, liquid shea Fat, soybean oil, camellia oil, corn oil, rapeseed oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, palm oil, palm kernel oil, owl, coconut oil, beef tallow, lard , Squalene, squalane, pristane or hydrogenated products of these oils and fats (hardened oil, etc.).
[0019]
(2) Wax
  Beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax, montan wax, shellac wax, rice wax, etc.
[0020]
(3) Mineral oil
  Liquid paraffin, petrolatum, paraffin, ozokelide, ceresin, microcrystalline wax, etc.
[0021]
(4) Fatty acids
  Natural fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid, docosahexaenoic acid, eicosapentaenoic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, lanolin fatty acid, Synthetic fatty acids such as isononanoic acid, caproic acid, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexanoic acid and isopentanoic acid.
[0022]
(5) Alcohols
  Natural alcohols such as ethanol, isopyropanol, lauryl alcohol, cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, phenoxyethanol, and synthetic alcohols such as 2-hexyldecanol, isostearyl alcohol, 2-octyldodecanol.
[0023]
(6) Polyhydric alcohols
  Ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol, polypropylene glycol, 1,3-butylene glycol Pentyl glycol, glycerin, pentaerythritol, threitol, arabitol, xylitol, ribitol, galactitol, sorbitol, mannitol, lactitol, maltitol and the like.
[0024]
(7) Esters
  Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyldodecyl myristate, hexyldecyl dimethyloctanoate, cetyl lactate, myristyl lactate, diethyl phthalate, phthalate Dibutyl acid, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate, and the like.
[0025]
(8) Metal soap
  Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate, etc.
[0026]
(9) Gums, sugars or water-soluble polymer compounds
  Gum arabic, benzoin gum, danmar gum, guaiac gum, Irish moss, Karaya gum, tragacanth gum, carob gum, quinseed, agar, casein, lactose, fructose, sucrose or esters thereof, trehalose or derivatives thereof, dextrin, gelatin, pectin, starch, Carrageenan, carboxymethyl chitin or chitosan, hydroxyalkyl (C2-C4) chitin or chitosan to which alkylene (C2-C4) oxide such as ethylene oxide is added, low molecular chitin or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorus Oxidized chitin or chitosan, alginic acid or salt thereof, hyaluronic acid or salt thereof, chondroitin sulfate or salt thereof, heparin, ethylcellulose, methylcellulose, carboxymethylcellulose, carboxy Siethyl cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyalkylene oxide such as polyethylene oxide and polypropylene oxide, or The cross-linked polymer, carboxyvinyl polymer, polyethyleneimine, etc.
[0027]
(10) Surfactant
  Anionic surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate ester salt, alkyl phosphate ester salt), cationic surfactant (alkylamine salt, alkyl quaternary ammonium salt), amphoteric surfactant: carboxylic acid Type amphoteric surfactant (amino type, betaine type), sulfate ester type amphoteric surfactant, sulfonic acid type amphoteric surfactant, phosphate ester type amphoteric surfactant, nonionic surfactant (ether type nonionic surfactant) Agent, ether ester type nonionic surfactant, ester type nonionic surfactant, block polymer type nonionic surfactant, nitrogen-containing type nonionic surfactant), other surfactants (natural surfactant, protein Hydrolyzed derivatives, polymer surfactants, surfactants containing titanium and silicon, fluorocarbon surfactants Etc..
[0028]
(11) Various vitamins
  Vitamin A group: retinol, retinal (vitamin A1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), Pyridoxine (vitamin B6), cyanocobalamin (vitamin B12), folic acid, nicotinic acids, pantothenic acids, biotins, choline, inositols, vitamin C group: vitamin C acid or derivatives thereof, vitamin D group: ergocalciferol (vitamin D2 ), Cholecalciferol (vitamin D3), dihydrotaxosterol, vitamin E group: vitamin E or derivatives thereof, ubiquinones, vitamin K group: phytonadione (vitamin K1), menaquinone (vitamin K2), menadione (vitamin 3), menadiol (vitamin K4), other essential fatty acids (vitamin F), carnitine, ferulic acid, .gamma.-oryzanol, orotic acid, vitamin P such (rutin, eriocitrin, hesperidin), vitamin U and the like.
[0029]
(12) Various amino acids
  Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine, arginine, ornithine, histidine And amino acid derivatives such as sulfate, phosphate, nitrate, citrate, or pyrrolidone carboxylic acid.
[0030]
(13) Various additives derived from plant or animal materials
  These are processed in a conventional manner according to the product type and form to be added (for example, pulverization, milling, washing, hydrolysis, fermentation, purification, pressing, extraction, fractionation, filtration, drying, pulverization) , Granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization and the like are arbitrarily selected and combined), and may be arbitrarily selected from various materials.
[0031]
  The solvent used for extraction may be selected in consideration of the intended purpose and type of the product to be provided or the processing to be performed later. Usually, water, methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol 1 type selected from various organic solvents such as lower alcohols such as isobutanol or hydrous lower alcohols, polyhydric alcohols such as propylene glycol, 1,3-butylene glycol and glycerin or hydrous polyhydric alcohols, acetone and ethyl acetate Alternatively, it is desirable to use a mixture of two or more. However, when it is not preferable to contain an organic solvent depending on the use, it is sufficient to use only water or ethanol that is easy to remove after extraction, and it may be used alone or in any mixture with water. The thing extracted and extracted may be sufficient.
[0032]
  In addition, when using additives derived from plant or animal-based ingredients for systemic or topical external preparations and cosmetics, it protects skin and hair, moisturizes, improves touch and texture, imparts flexibility, and stimulates Relaxation, stress relief by fragrance, cell activation (cell aging prevention), suppression of inflammation, improvement of skin and hair quality, prevention of rough skin and its improvement, hair growth, hair growth, hair loss prevention, imparting gloss, cleansing effect, In addition to cosmetic effects such as fatigue relief, blood flow promotion, and warm bath effects, effects such as flavoring, deodorization, thickening, antiseptic, and buffering can also be expected.
[0033]
  Specific plants (herbal medicines) as raw materials include, for example, almonds (toen), ai (indigo leaves), aokazura (Keifu Fuji), Aoki (Aoki), Aogiri or Kenashia Ogiri (Ao Tung), Aotsu Samurai (wooden candy) , Aotenma, acacia, red ginseng, red spruce `` fruit '', red clover, red grapes, red ginseng (logwood), red wrinkles (red buds), red crested or red crested or reddish (root), red crested or reddish (ground yellow), Agi (Aki), Aki larch, Akinire (crusted skin), Aguay Guassou, Aguahe (Omiten coconut palm), Akebi (Kitsu), Asa (Asakojin), Maruba morning glory or morning glory (Chicken), Hydrangea (hydrangea), Ashitaba (Tomorrow), Azuki (Red Azuki), Asunaro, Acerola, Asenyaku (Asenyaku), Athira (Shokuyokanna), Anise, Abiyu, A Biurana, oilseed rape, Abemaki `` fruit '', avocado, ama, achacha (Amacha), Achacharu, Amadokoro (Jade bamboo), Amana (a light-hearted), amaranth (Hyuyu, Hagatetou, Himogeito, Senninkoku, Sugimorigateto, Hosoaogeito, Hasoagoito Aozulan, Amaranthus hypochondriacus), Amigasayuri or Baimo (shellfish mother), Aristolomeria (Yurizuisen), Arcana (Alcanna), Algarrobo (Cabe), Altea, Arnica, Alpinia or Katsumadai (Suzukuku), Aloe (蘆薈), Aloe vera, angelica, apricot or honanzu (Anzujin), Ansokkou (benzoic incense), yellow support, igakozolina (geo-biliary head), licorice or gecko licorice (indian oyster), rush (light heart grass), itadori (tiger cane root), yew (one Place), Strawberry, fig (no flower `` fruit, leaf ''), Ichihatsu (first), Ichibi (winter lion), Ichiyakusou (one medicinal herb), ginkgo (Ginkgo `` seed, leaves ''), Japanese yellow peas (distant), carob, Japanese beetle ( Taillexi), Inubiyu (Honagainubiyu), Rice `` Seeds, Seed coat '', Inondo `` Seeds '', Ibuki-so-sou, Nettle, Ylang-ylang, Iwa-tobacco (Iwabuchi), Iwahiba or Iwamatsu (rolling mushroom), kidney beans, oolong tea, fennel (mustard) , Wheat (Chibusanoki), Ukiyara (Sanryo), Uguisukagura `` Fruit '', Himewikyo, Turmeric (Urban), Duckweed, Usubasaishin or Keirinsaishin or Oshusaishin (spicy), Usvenia Oy, Usbeni Hollyhock, phalaenopsis, weevil (summer hay), udo or shishiudo (gung, alone, tangy), unyadegato (unkari) A, Cat's Claw), Uba Tea, Ume (Plum Plum `` Seeds, Flesh ''), Vulgaris, Uwaurushi (Kusako-kemomo), Satsumikan (Chen), Unboku, Estragon, Ezoukogi (Tsuga Goka), Ezo-suzuran, Echinashi (Hosobamurasaki Barengiku) , Enishida, Enokitake (榎 茸), Ebisugusa or Cassia Tora (Keiko), El Campre, Elderberry “fruit”, Elemi, Elingi or Pre-Lotus Elinji, Enju (Safflower, Camellia rice), Pea, Ogi or Kibanaogi (Yellow Twilight), Naruko Yuri or Kagura-mabanaru Koyuri (Yellow), Ohisasa Yuki or Sasano Yuki, Ouren (Yo Ren), Ogata Houken, Okarasuri (Karokon), Oguruma (Civil Works Incense), Otsu Samurai (Prevention), Psyllium , Car forage), toucan thistle (Zhengzhou leakage, bald eagle), toucan Mi (coconut palm), Toucan cactus, Ovana okera or okera (white moth), Osara squirrel (Banaba), Ooyabaya shabushi "fruit", Oohashigusa (cereal sperm), Omia catechu, Oomihasa or hawthorn (Mountain vegetation), Omiyashi, Omiji Barley), Oka, Okazeri (snake bed), Okra `` fruit '', Oguruma (overturn), Oguri higotai (Zhengzhou leakage, indigo head), Panax ginseng or Tochibaninjin (Ginseng), Hypericum pertussis or Pterotus pertussis or Hypericum perforatum (Brother cut grass), Odorikosou (continuous), Onamomi (Circle ear), Onigomi, Onikoro or Tokoro or Nagadokoro (Hikai), Oninoyara (Tempa), Onyuri or Sasayuri or Hakatayuri (Yuri), Onoelan, Ononis, Halibut楡), Ominae (losing sauce), Yuuko, Dutch mustard (watercress), Ora Dazelli, Dutch beech, Dutch bees, olives `` fruit, seeds, leaves '', oregano, orange `` fruits, peels '', silkworm (ripe yellow), cacao `` fruits, peels, seeds '', oysters (bamboo `` leaves ''), Kagi-Kazura (Katsufuji), Kakidooshi or Kantorisou (Lotus), Kakiran, Gaku Hydrangea, Cassia, Casinoki (fruit berries), Gadju (Kashiwa), Kashiwa (Kashiwagi, Kashiwa), Cascarilla, Cascala Sagrada, gypsophila, gypsophila, cynomolgus (Kinshato), kaniwa, carnation, valerian (valerian), hippopotamus, birch or fern birch (white birch), gerbera, pumpkin, kapokoki `` seed '', kahoku salamander (蜀椒), gama Yellow), chamomile or roman chamomile, chamomile (weed), cam cam (camo duck), carraguwa or yamagwa (mulberry moth), color, caramel salmon, crow Cucumber or cinnamon cucumber (king moth), crow bishak (half-summer), oats, guarana `` seed '', carahoo (shock), karaya, galyu, karin (garden), garcinia, kawamidori, kawara psycho (commissioned vegetables, tranquilized grass) ), Kawajisha, Kawaratake, Kawaranadeshiko (stone bamboo) or Ezokawaranadeshiko (buckwheat, buckwheat), Chinese carrot (blue rice), Chinese mugwort (boiled rice cake), Kansui, Kanzo (licorice), Kantarasa, Kandelira, Kanto , Canna, kanran, raspberry (Ezo strawberry, Dutch strawberry, shrimp strawberry, nava white strawberry, maple strawberry, European raspberry), kiwi `` fruit, leaf '', kikarasuuri (guro-root), kiku (kikyo, bellflower root), chrysanthemum (chrysanthemum, chrysanthemum) ), Kikutanigiku, Kisagi (Kashimi), Gigigishi (Shione), Sword (Kashimi), Kizuta, Kaki Nigga aloe, yellow pepper, quina, linden (shinkona, red linden), quinoa (quinoa), yellowfin (yellow tuna), kimme, gymnema sylvesta, kimenkaku, cabbage, cabbage `` immature fruit '', caraway, cucumber, gyory (Nishikawa willow) Willow), Kiraja saponaria, Kiraya, Kiransou (golden grass), kumquat `` fruit '', kinkiju, ginsekai, kimbusen, betel, kinzhiki (sentsukakusa), quinlan, ginran, kinryohen, guapeba vermelya, guava `` fruit '', Guayule, Quercus Infectria, cucumber nuts, Kugenumaran, wolfberry (bamboo shoots, coconut leaves, cocoon leaves, ground bark), Japanese cedar (Tenmon Winter), kudu (kudzu), camphor tree, gooseberry `` fruit '', ginseng (Yellow Flower), Kutiti River, Gardenia ), Kunugi (Camellia), Kupuas, Kubeba, Kumazasa, Kumamatsura (horse whip grass), Clara (Bitter), Cranberry "fruit", Chestnut "seed, fruit, astringent skin", Curkurigo Latifolia "Fruit", Grapefruit "Fruit・ Leaf '', buckthorn, black spider (required), kamebahikokoshi or kurobanahikokoshi or hikikoshi (life-extending grass), cloves (clove, clove), gumbai tuna (sekimei, sekimeishi), kei-gai (bamboo shoot, spikelet), celosia (chicken crown flower) , Chicken clam), gekkavidin, bay bay laurel, Kenashi Sartorii rose (earthen soil, mountain return), gentian, genus shrimp (old lady), kemponashi (kigushi), kokisekoku, kushimikan (kouji, tachibana, oobenimikan, fukurican , Ponkan, Santara (Tachibana bark)), Koshinbara (moon flower), Ko Japanese peppermint, Kozo `` fruit '', Kocha (tea), Kohone (riverbone), Kohon (Tsubakimoto, Karatsumoto), Kouriang, Koryoko (Kora 姜), Cilantro `` fruit '', Koouren (Huo Ren), Koganebana (Yellow Gon) , Cowberry (Etsu Tachibana), coconut `` fruit '', goshuyu (gyu), gosho strawberry (covered bonsai), pepper (pepper), cosmos, copaiba balsam, coffee `` seed, leaves '', kobushi or magnolia (hot pepper), burdock ( (Beef bowl, beef eggplant), coconut lees, sesame (sesame seeds), sesame seeds (genus ginseng), trash beetle (gomisin), sakanekazura or binankazura or matsubusa, wheat (wheat), rice or rice bran `` red rice cake, white birch '', rice oil, cola Acuminata `` seed '', cola bella `` seed '', colony llya, fenugreek `` fruit '', colombo, kondurango, kombu, konjac, comfrey (sardine grass), sisal (sarum) Zaraasa), Sai Hairan, Sakaneran (Ezosakaneran), Sasima button eel or cinnabot eel or cinnamon ginseng (weizono), Sakura (Oshima cherry, Yamazakura, Oyamazakura, Edhigashi, Bean cherry, Miyazakura, Yoshino cherry, Takazakura, Sakura, Sakura `` Leaf, flowers, fruits, bark (cherry bark) '', cherries, pomegranates, Sasa, Sababaginran, Sasanka, Sagimodaka (Sawamata), sweet potatoes, sugar cane, sugar beet, saffron jujube (Sanbanjin, Safflower) ), Sapodilla, sapote mariyo, pomelo `` fruit '', savonsou, salmon berry `` fruit '', salamander (sasma), salamander (sand sashimi sashimi), salvia (sage), scallop (mountain vegetables), sawagurumi (mountain walnut) The Sakakusabo , Sangre de Grado (croton), Sansikuyosou, Sanshichininjin (Ginseng Ginseng), Sansyuyu (Yamazou), Sansho (Yamamuro), Sandskon (Yamazune), Shia (Kalite), Cyanoki `` fruit '', Shiitake mushroom, shion (purple spider), winged bean, jikitarisu, shikunshi (messenger), perilla or ajizo or chimmento or catamenzo (purple leaf, shisocho), rosewood, linden tree, syringion, syringae (ream), shimeji , Shakashimeji, Hatake-shimeji, Oshiroi-shimeji, Beech-shimeji, Honjimeshi, Shirotamogitake, Shimokuren (potato), Potato, Peonies (glaze), Shajin (Sanjin), Jasmine (Matsurika), Janohige (Bakumon winter), Djuxa Gypsophila, Shukushamitsu (sand seed, shredded sand), Juzdama, Shuro "fruit", Shun , Zouenashi, Ginger (Ginger), Zozan Hydrangea (Tsuneyama), Shobu (Koji, Sone), Shozu `` Fruit '', Shirakashi `` Seeds '', Silane (Bikkyu), Shirogoricho `` Seeds '', White clover (Clover), White cherry (Chicken bone grass), white squirrels (scented squirrels), white squirrel “flowers”, white sage lupine, shirominanten (southern tenm), cinchona sylbula, ginkgo biloba (mizuka, sika flower, shenzhen), cinnamon, cinnamum cassia (cinnamon) , Watermelon (Saijo), honeysuckle (gold and silver flowers, Shinobu), sorrel (Acid), swim berry `` fruit '', star apple, stevia, strawberry `` fruit '', tin-seed coconut (Sugar), sugina (question), purslane (horse teeth) (Skin, horse tooth tender), plum "fruit", sulgaran (oran), red pine "ball cone", caladium Tsutsu, izuri, gurumi, hawthorn, cedar, dandelion, horse chestnut (maronie), pear `` fruit '', elder, scallop (juniper, pine), yarrow (milfoil), rose , Atlantic butterfly, mistletoe, Atlantic mint or Atlantic mint (Dendrobium, sarcophagus), cedron (Bouchuboku), mallow, hirohasenega, senega, seri, celery, nematode (river cucumber), senshinren (centrifugal), sendan, sennin cacti , Senna `` fruit, leaf '', ginseng (daikon), sea bream (medicated), senboku, soka (grass), elephant chrysanthemum, buckwheat walnut, buckwheat `` seed '', potato monogram, broad bean, daikon (daikon), radish, soybean , Daidai (orange peel, fruit), Takasago Gurihigotai (southeast indigo sashimi), Takasaburo (Cirrus lotus), Takatodai (Daisatsu), Takarabi (Cirrus spine), dark sweet cherry `` fruit '', hollyhock, tachiakosou ( Thyme, Hyorika), Tachidokoro (Hikai), Tachiyanagi, Tamarind `` Seeds '', Onion, Tamshiba (hot pepper), Taranoki `` Fruits, leaves, root bark '', Tarayo (Large winter blue, Ichiha tea, bitter tea, bitter tea) , Dahlia (Tenjiku button), Tarwi, Tankimiri, Tanshichiwa, Tanjin, Dandelion or Shirobana Dandelion or Mouko Dandelion, Danmaru, Cherry Fruit ", Imperata" fruit, roots, buds ", the district Seth carrot (Takefushi carrots), chicory, chunker
Piedra (Kidachi Kumiso), Tulip, Chokono Stay, Datura (Artichoke), Datura (Dark Yellow), Datura (Lepidoptera), Datura Mulberry (Leaf), Choreimaitake (Dark), Chorogi, Tsukimiso, Tsukushikananeran , Tsukuritake (mushrooms), Tsuchiakebi, camellia, camellia, clover (lacquered vines), camellia (duck peas), tsuzukizuki (red bean), tsurutsukichibi, tsurudukudami (what neck rice cake), tsuruna (apricot apricot), tsuruninjin (four leaf ginseng) , Tsurume, Tsuwabuki, Deiko, Teuchigurumi, Duberry `` Fruit '', Tengusa, Tencha (boiled tea), Tendai-yaku (glaze), Toga (winter coconut), Toka Kazura, Pepper (Toban), Touki (Tokai), Tokinsenka (Marigold), honey bee, touna bena (river cut), corn or corn Rokoshi (Nanshige), Japanese potato (Sadako), Torindo or Chosenrindo (Dragon gall), Tokusa (wood band), Dokudami (10 medicines), Tokon (Nippaku), Toshishi or Maedaoshi or Neshikazura, Tochu (Tochu) Bark, leaves, roots ''), ash (crusts), tomatoes, tragacanth, triacanthus `` seeds '', eustoma, tormentilla, dronoki, troro-aoi, tongamame, nigerian berry `` fruit '', yam or yam (mountain medicine), nagii-kada ( Butcher Bloom), Naginata Koju, Nazuna, Rapeseed, Natsume or Natehaki (Sword Bean), Natsumikan, Jujube (Otsuchi), Naniwaibara (Golden Cherry), Navena (Suspended), Nameko, Nankin Bean (Peanut), Nanten (Southern Fruit) ), Namban Karamushi (Sesame), Niooi Sumire, Nigaki (Nakigi), Nigamugi (Sweet), Nikuzuku, Kei or Nicke Or Ceylon Nikkei or Yab Nikkei (Cinnamon) or Keishi (Keishi branch), Flying tiger plover, leek (lion), elderberry (bone, fruit, flower, stem, leaf), garlic (large cocoon), Nurde (penta), leek, Nemunoki or Nebu or Nebi or Nemurino or Digokubana (community), Noazami (Otsuka), Nobara (Natural), Nozenkazura (Lingen), Nogateto, Yarrow, Nodake (Mae-Hu), Novara, Peach, Pineapple `` fruit '', Hibiscus (Bussouge, Furinbusouge, Roselle), Hailindo, Hauchiwa, Pau Dorse, Hakama Labosi (bone fracture), Hakukayumatou, Nakusanchidori, Hakusen (white tinea), Hakulberry `` fruit '', Jacobe (breeding), hazelnut (lion), Hasirokoro (roth root), basil, lotus (lotus, lotus meat, lotus), parsley (holland jellies), hadakamugi, batata, bee Or madake (bamboo shoots), patchouli, peppermint (light load, light load leaf), yellow peas, pearl barley (Yokuinin), Hanasuge (my mother), banana, hana hakka, hanabishi (shitsuri, shitsuri), vanilla bins, papaya, scallops ), Pahalobobo, Hub `` Whole grass, stem, leaf '', Paprika, Hamakakiran, Hamago or Honeybee (Vulgaria), Hamasuge (Katsukiko), Hamabishi (Shitushi), Hermanus (Maika flower), Hamakoufu (Hamabofu) , Hamamelis, palm, rose (rose), balata, balata rubber tree, agaric (agaric, white-faced agaric, edulis), haran, parisurus, parietalia, harukanran, balsamina (crustacea, bittern), haruni (White skin, coral leaves), Barbasco, Harlindough, Handai Kai (Sakai Ocean), bread Ki, Hinogi (dried), Hikageturinjin (participant), pecan nuts, Higanbana (Ishizuchi, Bujushahua), Higurmadaria, Higotai, Hishi (Rishimi), Pistachio, Beet, Hitotsuba (Ishizuchi), Hitotsuba Enishi , Daisies (daisies), chicktails (cow knees), chickweeds, cypresses, hiba, castor, sunflower, peppers, himeuzu (tengu), himema (cense mushroom), himematsutake (kawariharatake, hiromatsutake), himemurayoran, pimenta ”, Beakshi, beakkyu, jade“ fruit ”, chickpea, lentil, belude oyster, white-bellied octopus (bald eagle), loquat“ fruit, leaf, stem ”, betel nut (large rind, coconut), puer tea (common tea) , Japanese quail (southern wicker), Japanese cypress, Japanese dandelion (Japanese winter flower, Japanese winter lobster), Japanese basil (Orchid), Japanese bean (Japanese peas), Japanese red fox (Chojiza) La, spikelets), grapes `` fruit, pericarp, seeds, leaves '', beech, scallops (Coleoptera), Brazilian licorice, Brazilian carrot, Brazilian palm, Brazilian elephant coconut, black currant `` fruit '', blackberry , Branjen, plum `` fruit '', fullcellaria, blueberry (Prunus serrata), prunes, floral blanca, blond psyllium, bundo (mung bean), hazelnut, loofah, hetsukaran, safflower (safflower), heneken, belladonna, berry `` fruit '', Percea, Pervianberg, Pereschia grandifolia, red beetle or duckweed (scenic sky), boysenberry `` fruit '', scallop or narcissus or nendo or hahagigi kokia (silk), horsiran, scallop Grass), Pouteria sa , Powteria lucuma, spinach, spinach, physalis (Torone), honoki (Japanese welfare, magnolia), bokeh (wooden moss), hosoba aragiku (painful york), hosobaoguruma, hosobana okera (salmon), cypresses 37), Hosobabarengiku, Bodaiju (bamboo tree), button (peony `` flowers, leaves, stems, bark ''), button pi (peony skin), hops, jojoba, borage (Lulichisha), Bordeaux, white berry `` fruit '', Hononiku (meat jugo, large art), Honsecukoku (iron skin stone, sparrow mountain stone wall), Myzuru tennansho (Tennan star), Maitake (maiko), maou (mao), maca, macadamia nut, margaret (mokushungiku), Macri (marine grass), Magwa (mulberry bark `` bark, leaf ''), magnolia splengeri, mazaran saba, masalan sauba de sear, masheira de boi, mash A (Tama no sen haren, Kyukonkinrenka), Matatabi (wood tengu), Matsukasa, pine `` leaves, bark, roots '', Matta Orillo, Matsuhodo (茯苓), Matico (Cordon Sillo), Mayoram (Hanahakka), Malvano jardin (Bitter), Mulberry `` Fruit '', Quince, Malene (Biloud Mouse Squid), Mango, Mangosteen, Manzanya (Andesuka Mitsuru), Manshugurumi, Mandarin `` Fruit '', Mannentake (Ganoderma biloba), Pheasant (fruit berry `` Fruit '') , Mishimasaiko (Saihu), Mizusobako or Mizuasagao (Dongweed), Mizokakushi (Half-sided lotus), Misohagi (Chinese green), Japanese willow or Japanese willow (Henpo), Mitsugasiwa, Mitsuba, Midorisapote, Mirimaza, Mimosa, Myoga, Miracle fruit `` fruit '', myrrh, mirobalan, wheat straw, mugweed, mugwort, Black sea bream (life-prolonging skin), munya, purple (purple root), purple purple or purple spotted purple (purple pearl), purple corn, purple pine fuji (Kunming chicken blood wisteria), megakansa opuntica, pheasant (beneficial herb), red-tailed primrose, evening primrose , Melaleuica, Melissa, Melilot, Melon `` fruit '', Moukomomogi, Mosouchiku, Mokkirin, Mogi (Pepper), Mochinoki, Mokko (woody incense), Momijidaio, Peach (peach `` leaves, seeds, flowers, fruit ''), Palm, Morello Cherry `` Fruit '', Morohaya (Hemp), Yakawa Murasakiimo, Yakuchi (Masashi), Cornflower (Yamagagi), Cornflower, Yacon, Yachabushi (Yagari) or Himeya Shabushi or Obayaya Shabushi `` Fruit, Skin, Fruit and Ear '' , Yachiyanagi, Yatsude (octagonal gold plate), mistletoe (willow infestation), willow (kawa Nagi, Japanese willow, Weeping willow, Red willow, Pussy willow, Incolyana nagi, Kinu willow, Koryanagi, Unryu willow, Miyama willow, Palm, Yamanagi, Obayanagi, Tairukunuyanagi, foxglove, Yam , Yabu tobacco (crane, Tenmeisei), pokeweed (commercial land), Japanese alder (Yamabuchi), Japanese yam (Yamamushi), Japanese mugwort, eucalyptus, Yukinoshita (tiger ear grass), Yucca or flavifolia, Yuzu "fruit", lily , Wormweed, Mugwort (Leaf), Ligan (Raimaru), Lime `` Fruit '', Rye, Lacanca `` Fruit '', Raspberry `` Leaf, Fruit '', Latania (Clamelia), Lackey or Shallot (Lady), Lavender, Longan ), Agave (Aonogave, Puff Agave), Ryokucha (green tea), apples `` fruit, seeds, leaves, roots '', gentian, rubus or suabisimus (cool), rulitama thistle (cold beetle, Xinjiang indigo head), litchi (toothpick, toothpick), lettuce (Chisha), red currant `` fruit '', red pitaya, lemon `` fruit '', lemongrass, forsythia or Chinese forsythia (ream), forsythia, wintersweet, wax palm, locon (reed, root), logan berry `` fruit ”, Rosemary (Mannenrou), Rosehip (Nobara), Wasabi, Watafujitsugi (Mitsumona), Waremokkou (earth).
[0034]
  As seaweeds, seaweed [green algae: Chlorella vulgaris, Chlorella pyrenoidosa, Chlorella ellipsoidia, Aonori (usba aonori, Sugiaonori, Hiraaoori, Boaonori, Hosoeda Aonori), seaweed [Brown algae] (Macombu, Resilibu, Hosocome, Mitsuishi Kombu), Wakame, Hirome, Aowakame, Giant Kelp (Macrocystis Integrifolia, Neocitus Ruetkeana), Hijiki, Hibamata, Umiuchiwa, Usubaumiuchiwa Umiuchiwa, Akaba Umiuchiwa, Konami Uchiwa, Okinawa Uchiwa, Usuki Uchiwa, Etuki Umi Uchiwa], seaweed [Red Algae: Hijirimen, Maca (Tengusa), Hiluxa, Syria, Oaxa Caterpillar, Yatabegusa, Yuukiri, Shimatengusa, Tosakanori, Togekirinsai, Amakusakirinsai, Giraffe, Juniper ginkgo rhinoceros, Tsunomata, Totsuka (Yahazutsu notamata), Ezotsunotamata, Togetu no Takita , Yaleus banori, Kagius banori, Susius banori, Haius banori, Akamo mizunori] and the like.
[0035]
  In addition, other algae such as green algae (Chlamydomonas: Chlamydomonas, Akayukimo, Dunaliella: Dunaliella, Chlorococcus: Chlorococcus, Anemone: Quanomomo, Volbox: Ougenmawari, Volbox, Palmera, Yotsumeo, Aomido: Chrysanthemum, Aoumidro, Tirguimidro, Hibidoro: Hibidoro, Aosa: Anaaaosa, Amiaosa, Nagaaosa, Kawanori: Kawanori, Friccella, Shiogusa Magama genus: Magamata, Iwagata: Fusaikawa, Surichogata, Heraiwata, Kurokita, Hanemo, Genus: Mill, Chromel, Sakibutimil, Nagamil, Hira Lemon, Casanori genus: Casanori, Jusmo genus: Jujusmo, Tamajusmo, Mizojuzumo, Mika ヅ kimo, Korekaete, Tsutsumimo genus: Kyukougusa, Hitogususa genus: Humanegusa, Hirohatohigususa, Umushihimoe, Sakikimoe Sumiremo: Sumiremo, Hoshimamidro, Fushinashimidoro etc.).
[0036]
  Cyanobacteria (Suizenjinori genus: Suizenjinori, Aoko genus, Nenjumo genus: Kawatake, Ishijelly, Hassai, Yuremo, Rasenmo (Spirulina): Spirulina, Trichodesmium (Iaciasio), etc.).
[0037]
  Brown alga Sanadagusa: Sanadagusa, Fukurimamiji, Commongusa: Commongusa, Yahazugusa: Ezoyahaz, Yahazugusa, Uraboshiyahaz, Jigamusa: Jigmygusa, Umichiwagusa, Umamisakugakua, Hakusou : Navarimo, Chasomen genus: Motsuki Chasomen, Matsumo genus: Matsumo, Nagamatsumo genus: Nagamatsumo, Okinawa mozuku: Okinawa mozuku, fake Tomozuku: Niseft Mozuku, Futomozuku: Futomozuku, Ishimozuku: Ishimozuku, Kuromo: Kuromo, Nisemozuku: Nisemozu, Mozuku: Mozuku, Ishige: Ishige, Iroro, Ichimosa: Ichimegasa Umibosu, Urushigusu: Urushigusa, Keurushigusa, Tobaccogusa, Composita: Composita, Haberodomo: Haberodoki, Havanori: Habanori, Habanori: Habanori, Commonbukuro, Ezobukuro, Ezobukuro Chishima fukuronori genus: Chishima fukuronori, Kagomenori genus: Kagomenori, Muraridori genus: Murachidori, shark genus: shark zusa, genus genus: iwahige, yokojimamanori: Ganoderma genus: cynomolgus, fennel spider: fennel spider, vine genus: turmo, turtle genus: sea turtle, scorpion genus: sujime, misji kumbu genus: misji kumbu, atsuba misji kumbu, kumbu genus: tsutsugara kumbu, oyster kumbu, onikombu, gakonbubu Barracuda, Trollocombu: Trollocombu, Antokume: Antokume, Kajime: Kajime, Tsuruarame, Kurome, Kikuishikombu: Kikuishicombu, Nejikcombu: Nejicombu, Kuroshiome: Kuroshiome, Nekoshikonbu, Aramei Genus: Ainuwakame, Chigaiso, Oniwakame Ezoi Shige: Ezoi Shige, Yabane Moku: Yabane Moku, Rappa Moku: Rappa Moku, Joromoku: Ugano Moku, Jo Lomoku, Hiemoku, Honda Walla: Tamanashimoku, Isomoku, Nagashimamoku, Akamoku, Shidamoku, Honda Walla, Nejimoku, Narasamo, Mametawala, Tatsukuri, Yatsumata Moku, Umitora no Moku, Fushishimoku, Mohmokumoku, Hahamokumoku , Genus Ukimo: Ouokimo, genus Burukimo: burukimo, genus Kayamonori, etc.).
[0038]
  Red algae Genus: Sea urchins, Tsukumonori, Anemone crickets, Astragalus, Amaranthus, Amaranthus, Agaricata Genus: Tamaitadaki, Kaikekenori Genus: Kaginori, Kaikekenori, Tengusa: Himetengususa, Hytengususa, Oobusa, Nambugu , Kohira, Yohira, Kinukusa, Hibirodo: Hibirodo, Himebiro, Isomumedo: Isommedo, Aedes: Rhizome, Ryumons: Ryumon, Ranunculaceae, Nisekare Naminohana: Hosobanaminohana, Naminohana, Sangomodoki: Ragaramomodoki, Shiogusagoromo: Shiogusagoromo, Iwanokawa: Etsukiiwanawa, Kinokawa: Kinokawa, Kanonote, Sangori Kyono Shiro, Sakuranori, Nikumukade, Tambanori, Tsurutsuru, Fudarak, Marubahdarak, Isonohana: Nurakusa, Ronulaksa, Oomkadenori, Hirakintoki: Hirakintoki, Matabou: Matabou, Kintoki: Chabokintoki, Kintoki, Matsunori, Rice, Tokamatsu, Hitomatsu, Fushikintoki, Tsunomude, Nagakinito, Crayfish Nagaobane: Naganobane, Funori genus: Hanafonori, Fukurofunori, Mafunori, Karekigusa: Karekigusa, Tosakamodoki: Hosobanatosakamodoki, Hironotosakamodoki, Yatsudegatatosakamodoki, Kurotosakamodokisane, Zotosofomoza Tosakamodoki, Nankaitosakamodoki, Himetosakamodoki, Kinuhada: Kinuhada, Ezotosaka: Ezotosaka, Tsukasanori: Enashikarimenia, Otsukasanori, Hana Tacarimenia, Hoonoo: Honoo, Hikagenoit: Hikagenoit, Usuginu, Nikuhounoo: Nikuhounoo, Venus nago, Venus nago, Susca veni: Suscabeni, Okarugusa: Yamadagusa, Mirin: Mirin, Hosokamiso , Isomocca genus: Isomocca, Yukari genus: Yukari, Hosoyukari, Ibaranori genus: Ibaranori, Saidaibara, Tachiibara, Kagibaranori, Kojinoo: Kizino-o, Isodantsu: Isodantsu, Atsubanori: Atsubanori, Ogonori, Ogonori, Ogori Mizo-okonori, birch, beniogonori, fukureshinori, purple birch, shinkaibanori, spruce birch, kataogonori, ryukyuogono Li, Atlantic scorpion, Ivy genus, Yumigataonori, Kubireogonori, Mosagogonori, Kinubanori, Amanita genus: Hachijotensamodoki, Fushikenori genus: Fushikenori, Namiiwatake, Nymphalanthus Itagususa, Saimi, Hari, Lotus Jigusa: Lotus Jigusa, Sugi nori: Ikanoashi, Hosoibonori, Nobonori, Black Haginansou Genus: gourd, cherries, octopus: octopus, sedge, genus: genus, genus: goat, dals : Dulse, Scorpionus, Anadalus, Weibusa: Uebusca, Benifronori: Benifuronori, Fusunagi: Futsutsunagi, Himefusunagi, Hirohafushitsugi, Otsunagisou, Hirawatagigi, Usuwasugi , Egonori: Egonori, Futogigi, Saeda: Saeda, Chirimomiji: Chirimomiji, Konohori family: Habutaenori, Konohori, Suzuronori, Usubeni: Genus: Kagios banori, Yareus banori, Susius banori, Heius banori, Usubanorimodoki: Usubanorimodoki, Ayanishiki genus: Ayani Genus: Aeginu, Dadia: Enasidadia, Shimadadia: Isohagi, Shimadadia, Dajimodoki: Dajimodoki, Euglena: Morayogusa, Fuyugusa, Makuri: Makri, Yanaginogi, Yuna, Yukinagina , Sasabayanaginori, Sozo genus: Kurosozo, Kobsozo, Hanesozo, Sozonohana, Hanegusa genus: Hananegusa, Hananegusa, Kozanemo genus: Kozanemo, Isomurasaki, Hosozozanemo, Himegoshigusu, Giant genus Isomagusa, Suginasugusa: Suginasusa, Isobashou: Isobasho, Fujimatsumo: Fujimatsumo, Sawweed: Haeshinosakiba, Kawamoku : Kawamoke, Aokawa Mozuku, Himekawa Mozuku, Ideyugogome: Ideyugogome, Okichimozuku: Ochimodoku, Otosa, Chinorimo: Chinomo, Chisujinori, Chisujinori, etc.).
[0039]
  Axial algae (Shajikumo, Shiratamamo, Hoshitsurimo: Hoshitsurimo, Rikunotamnus, Flaskmo: Himebumo, Chaboflasmo, Tripera, etc.), yellow algae (Hikarimo: Hikarimo, etc.), etc.
[0040]
  In addition, the materials derived from animal materials include chicken crown extract, cow or pig, human placenta extract, cow or pig stomach, duodenum, intestine, spleen extract or decomposition product thereof, cow or pig brain tissue Extracts, cattle / pig or fish collagen hydrolyzate (acid, alkali, enzyme etc.) degradation products, water-soluble collagen or collagen derivatives such as acylated collagen, cow or pig elastin or elastin hydrolyzate (acid, alkali, Enzymes etc.) or water-soluble elastin derivatives, keratin and its degradation products or their derivatives, silk proteins and their degradation products or their derivatives, porcine or bovine blood cell protein degradation products (globin peptides), cattle or porcine hemoglobin degradation products (Hemin, hematin, heme, protoheme, heme iron, etc.), milk, casein and its degradation products or their derivatives, skim milk powder and their degradation products or their inducements Body, lactoferrin or decomposed product thereof, egg ingredients, fish hydrolyzate, nucleic acid-related substance (ribonucleic acid, deoxyribonucleic acid), or the like.
[0041]
  In addition, as a material derived from a plant or animal material, any site, cell, tissue, organ, metabolite, etc. derived from a gene recombinant or a cell fusion can be used. Furthermore, for example, an undifferentiated cell group, a cell group in the middle of differentiation, or the like obtained by culturing an arbitrary site, cell, tissue, organ or the like can also be used.
[0042]
(14) Marine components
  Seawater such as deep sea water, for example, sea salt, dried seawater, dead sea or Atlantic or Pacific sea water (sodium chloride, magnesium chloride, potassium chloride, etc.), sea mud or mud (fango), for example Sea mud or mud from various locations such as Italy, Fango, German Fango, Eifel Fango, Freiburg Fango, etc. (Ingredients: silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, manganese oxide, sodium oxide, potassium oxide, magnesium oxide, calcium oxide Strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic, water), saintoku stone, black meteorite, etc.
[0043]
(15) Microbial culture metabolites
  Yeast metabolite, yeast extract, bacterial metabolite, bacterial extract, mold or actinomycete metabolite, mold or actinomycete extract, natto metabolite, natto extract, rice fermented extract, rice bran (red rice cake, birch ) Fermented extract, Euglena extract or decomposition product thereof or water-soluble derivative thereof, trehalose or derivative thereof, lactic acid fermentation product of raw milk or skim milk powder, lactic acid bacteria fermentation product of legumes, lactic acid bacteria fermentation product of coconut genus plant, etc.
[0044]
(16) α-hydroxy acids
  Glycolic acid, citric acid, malic acid, tartaric acid, lactic acid, etc.
[0045]
(17) Inorganic pigment
  Silica, magnesium silicate, talc, kaolin, bentonite, mica, mica titanium, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide, titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide , Gunjo, chromium oxide, chromium hydroxide, carbon black, calamine, etc.
[0046]
(18) UV absorption / blocking agent
  Benzophenone derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate, dihydroxydimethoxybenzophenone, dihydroxydimethoxybenzophenone-sulfone Acid sodium, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), paraaminobenzoic acid derivatives (paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate, etc.) , Methoxycinnamate derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate, octyl paramethoxycinnamate, 2-ethoxyethyl paramethoxycinnamate, paramethoxycinnamate Acid sodium, potassium paramethoxycinnamate, glyceryl diparamethoxycinnamate mono-2-ethylhexanoate, etc.), salicylic acid derivatives (octyl salicylate, phenyl salicylate, homomenthyl salicylate, dipropylene glycol salicylate, ethylene glycol salicylate, myristyl salicylate, methyl salicylate, etc.) , Anthranilic acid derivatives (such as methyl anthranilate), urocanic acid derivatives (such as urocanic acid, ethyl urocanate), coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, Furan derivatives, pyrone derivatives, nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives, vitamin B6 derivatives, umbelliferone Esculin, benzyl cinnamate, cinoxate, oxybenzone, dioxybenzone, Okutabenzon, sulisobenzone, benzo resorcinol, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, Neo Heliopan, ESCA rolls, zinc oxide, talc, kaolin.
[0047]
(19) Whitening agent
  Paraaminobenzoic acid derivatives, salicylic acid derivatives, anthranilic acid derivatives, coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives, nucleic acid derivatives, allantoin derivatives Nicotinic acid derivatives, vitamin C or derivatives thereof (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), vitamin E or derivatives thereof, kojic acid or derivatives thereof, oxybenzone, benzophenone, arbutin, guaiazulene, shikonin, baicalin, baicalein , Berberine, placenta extract, ellagic acid, lucinol etc.
[0048]
(20) Tyrosinase activity inhibitor
  Vitamin C or a derivative thereof (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), hydroquinone or a derivative thereof (hydroquinone benzyl ether, etc.), kojic acid or a derivative thereof, vitamin E or a derivative thereof, N-acetyltyrosine or a derivative thereof , Glutathione, hydrogen peroxide, zinc peroxide, placenta extract, ellagic acid, arbutin, lucinol, silk extract, plant extract (camille, mulberry, gardenia, touki, firewood, clara, mugwort, honeysuckle, yellowfin, dokudami, matsuhod, Pearl barley, nettle, hops, hawthorn, eucalyptus, yarrow, altea, keihi, mankei, hamamelis, carraguwa or yamagwa, life-grass, bellflower, toshishi, sequel, shooting dry, mao, senkyu, dokatsu, psycho, Ufuu, littoralis, Scutellaria, peony bark, peony, cranesbill, kudzu root, licorice, Fushi aloe, Cimicifuga, safflower, green tea, black tea, Ali elixir), and the like.
[0049]
(21) Melanin pigment reduction / degradation substances
  Phenylmercury hexachlorophene, mercuric oxide, mercuric chloride, hydrogen peroxide, zinc peroxide, hydroquinone or its derivatives (hydroquinone benzyl ether).
[0050]
(22) Turnover promotion / cell activator
  Hydroquinone, Lactic acid bacteria extract, Placenta extract, Ganoderma extract, Vitamin A, Vitamin E, Allantoin, Spleen extract, Thymus extract, Yeast extract, Fermented milk extract, Plant extract (Aloe, Ogon, Horsetail, Gentian, Burdock, Shikon, Carrot, Hamamelis, Hop, Yokuinin, Odori Sou, Assembly, Toki, Toki Senko, Achacha, Hypericum, Cucumber, Ginger, Mannenrou, Parsley).
[0051]
(23) Astringent
  Succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc paraphenol sulfonate, potassium aluminum sulfate, resorcin, ferric chloride, tannic acid (including catechin compounds), etc.
[0052]
(24) Active oxygen scavenger
  SOD, catalase, glutathione peroxidase and the like.
[0053]
(25) Antioxidants
  Vitamin C or a salt thereof, stearic acid ester, vitamin E or a derivative thereof, nordihydrogua ceretenoic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, parahydroxyanisole, propyl gallate, sesamol , Sesamorin, gossypol, propolis, etc.
[0054]
(26) Lipid peroxide production inhibitor
  β-carotene, plant extract (sesame cultured cells, amacha, hypericum, clams, clove, melissa, enamel, birch, salvia, mannenrou, nanzenji, ages, ginkgo, green tea).
[0055]
(27) Anti-inflammatory agent
  Ictamol, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d-camphor, dl-camphor, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, glycyrrhizic acid or its salt, glycyrrhetinic acid or its Salt, licorice extract, sicon extract, age extract, propolis, etc.
[0056]
(28) Antibacterial / disinfectant / disinfectant
  Acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or its hydrolyzate, alkyldiaminoethylglycine chloride solution, triclosan, sodium hypochlorite, chloramine T, salicy powder, iodine compound, iodoform, sorbin Acid or salt thereof, propionic acid or salt thereof, salicylic acid, dehydroacetic acid, parahydroxybenzoic acid esters, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p-chloro-m -Xylenol, p-chloro-m-cresol, thymol, phenethyl alcohol, O-phenylphenol, Irgasan CH3565, halocarban, hexachlorophene, chlorohexidine, ethanol, methanol Isopropyl alcohol, benzyl alcohol, ethylene glycol, propylene glycol, 2-phenoxyethanol, 1,2-pentanediol, zinc pyridione, chlorobutanol, isopropylmethylphenol, nonionic surfactant (polyoxyethylene lauryl ether, polyoxyethylene nonyl) Phenyl ether, polyoxyethylene octyl phenyl ether, etc.), amphoteric surfactant, anionic surfactant (sodium lauryl sulfate, lauroyl sarcosine potassium, etc.), cationic surfactant (cetyltrimethylammonium bromide, benzalkonium chloride, benzethonium chloride) , Methylrosaniline chloride), formaldehyde, hexamine, brilliant green, malachite green, crystal violet, jarmal, feeling Photoelement 101, Photosensitive element 201, Photosensitive element 401, N-long chain acyl basic amino acid derivatives and acid addition salts thereof, zinc oxide, hinokitiol, kudin, propolis, and the like.
[0057]
(29) Moisturizer
  Glycerin, propylene glycol, 1,3-butylene glycol, polyethylene glycol, glycerin tricaprycapric acid, glycolic acid (α-hydroxy acid), hyaluronic acid or its salt, chondroitin sulfate or its salt, water-soluble chitin or its derivative or chitosan derivative Pyrrolidonecarboxylic acid or a salt thereof, sodium lactate, urea, sorbitol, amino acid or derivative thereof (valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, Tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine, arginine, ornithine, histidine and their sulfates and phosphates Nitrate, citrate, or pyrrolidone carboxylic acid), fats and oils “Avocado oil, almond oil, fennel oil, sesame oil, olive oil, orange oil, orange rafa oil, sesame oil, cacao butter, chamomile oil, carrot oil, cucumber oil, Beef tallow fatty acid, quince seed oil, cucumber nut oil, safflower oil, shea fat, liquid shea fat, soybean oil, camellia oil, corn oil, rapeseed oil, jojoba oil, persic oil, castor oil, sunflower oil, cottonseed oil, peanut oil, Turtle oil, tea tree oil, mink oil, egg yolk oil, palm oil, palm kernel oil, molasses, palm oil, eucalyptus oil, beef tallow, lard, squalene, squalane, pristane or hydrogenated products of these oils (cured oil) , Waxes (beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, Lanolin, candelilla wax, montan wax, shellac wax, rice wax), mineral oil (liquid paraffin, petrolatum, paraffin, ozokelide, ceresin, microcristan wax), natto bacteria metabolites, natto extract, silk fiber extract, plant extract (Akamatsu) Sap, aloe, kudzu, chamomile, licorice, cucumber, licorice, rice or rice bran, purple root, birch or white birch sap, assembly, mulberry white bark, maple leaf, loofah, peony skin, persimmon), etc.
[0058]
(30) Elastase activity inhibitor
  Fluorophosphate diisopropyl, plant extract (Ogon, Hypericum, Clara, Mulberry leaves, Keihi, Gennosho, Comfrey, Salvia, Elderberry, Bodaige, Buttonpi), seaweed extract, etc.
[0059]
(31) Hair preparation
  Selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thianthol, castari tincture, pepper tincture, red pepper tincture, quinine hydrochloride, strong aqueous ammonia, potassium bromate, sodium bromate, thioglycolic acid and the like.
[0060]
(32) Antiandrogen
  Follicular hormone (estrone, estradiol, ethinyl estradiol, etc.), isoflavone, oxendron, etc.
[0061]
(33) Peripheral blood flow promoter
  Vitamin E or its derivatives, assembly extract, garlic extract, carrot extract, aloe extract, gentian extract, toki extract, cephalanthin, carpronium chloride, minoxidil and the like.
[0062]
(34) Stimulant
  Pepper tincture, nonyl acid vanillamide, cantalis tincture, ginger tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate, etc.
[0063]
(35) Metabolic active agent
  Photosensitizer 301, hinokitiol, pantothenic acid or derivatives thereof, allantoin, placenta extract, biotin, pentadecanoic acid glyceride and the like.
[0064]
(36) Antiseborrheic agent
  Pyridoxine or derivatives thereof, sulfur, vitamin B6 and the like.
[0065]
(37) Keratolytic agent
  Resorcin, salicylic acid, lactic acid, urea, etc.
[0066]
(38) Oxidizing agent
  Hydrogen peroxide solution, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, sodium pyrophosphate, sodium orthophosphate Sodium silicate hydrogen peroxide adduct, sodium sulfate hydrogen peroxide adduct, sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution, mushroom extract, etc.
[0067]
(39) Hair remover
  Inorganic reducing agents such as strontium sulfate, sodium sulfide, barium sulfide, calcium sulfide, thioglycolic acid or its salts (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate) etc.
[0068]
(40) Hair swelling agent
  Ethanolamine, urea, guanidine, etc.
[0069]
(41) Dye agent
  5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol, 2,4-diaminophenoxyethanol hydrochloride 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, orthoaminophenol, N-phenyl acetate Paraphenylenediamine, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-diamine, nitroparaphenylenediamine, paraaminophenol, para Nitroorthophenylenediamine, paraphenylenediamine, paramethylamino Phenol, picramic acid, sodium picramate, N, N'-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N -Phenylparaphenylenediamine, metaaminophenol, metaphenylenediamine, 5-aminoorthocresol sulfate, 2-amino-5-nitrophenol sulfate, orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diamino sulfate Diphenylamine, 2,4-diaminophenol sulfate, toluene-2,5-diamine sulfate, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, parasulfate sulfate Methylaminophenol, metaaminosulfate Diol, metaphenylenediamine sulfate, catechol, diphenylamine, α-naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcin, tannic acid, 2-hydroxy-5-nitro-2 ', 4'-diaminoazobenzene-5'-sulfone Sodium acid, hematein, etc.
[0070]
(42) Fragrance
  Natural animal fragrances such as musk, civet, castrium, ambergris, anise essential oil, angelica essential oil, ylang ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, guayakwood essential oil, cumin essential oil, black letter Essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, gingergrass essential oil, cedar essential oil, spearmint essential oil, western peppermint essential oil, dairy perfume essential oil, Tuberose essential oil, dichroic essential oil, orange flower essential oil, winter green essential oil, trubalsum essential oil, buttery essential oil, rose essential oil, palmarosa essential oil, cocoon essential oil, hiba essential oil, sandalwood essential oil, petit gren essential oil, bay essential oil, vetiva essential oil, bergamot essential oil, pel Plant flavors such as balsam essential oil, boad rose essential oil, melamine essential oil, mandarin essential oil, eucalyptus essential oil, lime essential oil, lavender essential oil, linaloe essential oil, lemongrass essential oil, lemon essential oil, rosemary (mannenrou) essential oil, Japanese mint mint essential oil, etc. Synthetic fragrance etc.
[0071]
(43) Dyes / colorants
  Red cabbage dye, red rice dye, red dye, anato dye, scum dye, turmeric dye, enju dye, krill dye, amber dye, caramel, gold, silver, gardenia dye, corn dye, onion dye, tamarind dye, spirulina dye, Buckwheat whole pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin etc.
[0072]
(44) Other
  Hormones, sequestering agents, pH adjusters, chelating agents, antiseptic and antibacterial agents, fresheners, stabilizers, emulsifiers, animal and vegetable proteins and their degradation products, animal and vegetable polysaccharides and their degradation products , Animal / plant glycoproteins and their degradation products, blood flow promoters, anti-inflammatory agents / anti-inflammatory agents / anti-allergic agents, wound treatment agents, foam enhancers, thickeners, enzymes, purified water (electronic water, small clusters) Etc.), oral preparations, deodorizing / deodorizing agents, bittering agents, and the like, and by using these in combination, an additive or synergistic improvement of the effects of the present invention or other cosmetic effects can be expected.
[0073]
  In the present invention,Active oxygen scavengerThe addition method may be added in advance or may be added during production, and may be appropriately selected in consideration of workability.
[0074]
【Example】
  Hereinafter, production examples, test examples, and formulation examples will be described. However, the present invention is not limited to these examples.
[0075]
(Production Example 1)
  Bengal Karachi, Miracle Berry, Lemongrass100 g of various dried plants are heated and extracted with purified water (about 80 ° C.) for about 5 hours and filtered to obtain about 1.0 kg of an extract (dry solid content: about 0.1 to 2.5% by weight).
[0076]
(Production Example 2)
  Bengal Karachi, Miracle Berry, Lemongrass100 g of various dry plants are immersed in a 50% ethanol solution, extracted at room temperature for 5 days and nights, and then filtered to obtain about 1.0 kg of an extract (dry solid content: about 0.1 to 2.5% by weight).
[0077]
(Production Example 3)
  Bengal Karachi, Miracle Berry, Lemongrass100 g of various dry plants of 100%, soaked in 70% ethanol solution, 70% 1,3-butylene glycol solution, 60% propylene glycol solution or purified water (about 30 ° C), extracted at room temperature for 5 days and nights, filtered Thus, about 1.0 kg of an extract (dry solid content: about 0.1 to 3.0% by weight) is obtained.
[0078]
(Test 1) Active oxygen elimination (SOD-like activity) test
  In recent years, many diseases and illnesses induced by active oxygen have been reported, and it has been pointed out that removal and elimination of active oxygen (SOD activity) leads to prevention of tissue damage. In this test, the extract obtained in Production Example 2 has the ability to eliminate active oxygen generated by the xanthine-xanthine oxidase system by the present NBT method (lipid peroxide experimental method, p. 144, medical and dental drug publishing). ).
[0079]
"Test method and evaluation method"
  In a small test tube, 0.05M sodium carbonate buffer solution (pH 10.2), xanthine and ethylenediaminetetraacetic acid dissolved to 3.0 mM each in 2.6 mL substrate solution, 0.75 mM nitroblue tetrazolium (NBT), 0.15 W / Add 0.1 mL of V% bovine serum albumin and sample solution (the solvent for the control) and leave at 25 ° C for 10 minutes. Then, 0.1 mL of an aqueous xanthine oxidase solution adjusted to have an absorbance change of about 0.3 / 20 minutes in advance was added, and after standing at 25 ° C. for 20 minutes, the reaction was stopped by adding 0.1 mL of 6.0 mM CuCl solution, Absorbance at 560 nm was measured. In addition, the sample in which the solvent of the sample solution was added instead of the sample was used as a control, and the active oxygen scavenging rate (= active) was calculated using the group in which the reaction stop solution was added before adding xanthine oxidase for the sample and control as blank. The results are shown in FIG.
"sample"
  In addition, the sample of the active oxygen elimination (SOD-like activity) test was subjected to the test using the extract (solid content concentration: adjusted to 0.5%) obtained in Production Example 2 of the present invention. As a comparative sample, a Tochu extract (made by Ichimaru Falcos Co., Ltd.), which is known to have an active oxygen scavenging action, was prepared under the same conditions and used in the test.
[0080]
[Equation 1]
  Active oxygen elimination rate (%) = {1− (Sample O.D. value−Blank (sample) O.D. value) / (Control O.D. value−Blank (control) O.D. value)} × 100
[0081]
(Test results)
  As shown in FIG.Bengal Karachi, Miracle Berry, LemongrassIt was confirmed that the extract significantly suppressed the generation of active oxygen and had an active oxygen scavenging action. In addition, it can be confirmed that it has almost the same or strong active oxygen scavenging action as compared with the control (Sunaka extract), and can therefore be used as an active oxygen scavenger.
[0082]
(Test 2) Safety test
  (1) Skin primary irritation test
  Various plant extracts obtained in Production Examples 1 to 3 were prepared in purified water so that the dry solid content concentration was about 1.0%, and Japanese white rabbits (shaved back) (female, 3 per group, (Approx. 2.3 kg body weight). 24, 48, and 72 hours after application, evaluation was performed using erythema and edema as an index based on the criteria for Draise. As a result, in all animals, no erythema and edema were observed, and it was judged that there was no problem with primary skin irritation.
[0083]
(Test 3) Safety test
  (2) Cumulative skin irritation test
  Similarly, various plant extracts obtained in Production Examples 1 to 3 were prepared in purified water so that the dry solid content concentration was about 1.0%, and the Hartley guinea pig (female, 3 per group, shaved back) (Approx. 320 g body weight), 0.5 mL / animal was applied once a day, 5 times a week. Application was performed over 2 weeks and shaving was performed on the last application day of each week. Evaluation was performed using erythema and edema as indices based on the criteria for Draise on the day after each application and the day after the last application. As a result, in all animals, no erythema and edema were observed for 2 weeks, and it was judged that there was no problem with respect to cumulative skin irritation.
[0084]
(Test 4) Safety test
  (3) Single dose toxicity study
  The various plant extracts obtained in Production Examples 1 to 3 were adjusted with purified water to a concentration of 12.5%, and ddy mice (male and (Female, 1 group, 5 animals, 5 weeks of age) were orally administered, and the onset, degree, etc. of toxic symptoms were observed over time. As a result, no abnormalities were observed in all mice for 14 days, and no abnormalities were found in the anatomical results. Therefore, LD50 was 2,000 mg / kg or more, and judged to be a safe substance.
[0085]
(Formulation example) Production of active oxygen scavenger and cosmetic composition
  According to said evaluation result, the example of the formulation is shown below, but each formulation example may be what was manufactured by the conventional method in manufacture of each product, and showed only the compounding quantity. The present invention is not limited to these.
[0086]
(Formulation Example 1) Milk Mass%
    1.Squalane 5.0
    2.Olive oil 5.0
    3. Jojoba oil 5.0
    4.Cetyl alcohol 1.5
    5. Glycerin monostearate 2.0
    6.Polyoxyethylene (20) cetyl ether 3.0
    7. Polyoxyethylene (20) soorbitan monooleate 2.0
    8.1,3-Butylene glycol 1.0
    9.Glycerin 2.0
   Ten. C: Bengal Karatachi extract of Production Example 2
      D: Miracle berry extract of Production Example 2
      F: Lemongrass extract of Production Example 2
      *C ~ FAny one of the extracts 5.0
   11.Perfume appropriate amount
   12.Residue with 100 purified water
[0087]
(Prescription example2) Cosmetic oil mass%
    1.liquid paraffin 30.0
    2.Squalane 20.0
    3.Olive oil 20.0
    4.Isopropyl palmitate 10.0
    5. Lemongrass extract from Production Example 1 3.0
    6. Clove hot water extract 1.0
    7. Grapefruit fruit or leaf hot water extract 1.0
    8. Tochu Nakaba Hot Water Extract 1.0
    9. Soybean seed hot water extract 1.0
   10.Olive oil 1.0
   11. Shea fat 1.0
   12.Butylhydroxyanisole 0.1
   13. Vitamin E derivative 0.1
  14. Antibacterial and antiseptic (benzalkonium chloride) appropriate amount
   15. Perfume (rose water) appropriate amount
   16.Residue with 100 purified water
[0088]
(Prescription example3) Cold cream mass%
    1. Sarah Beeswax 11.0
    2.liquid paraffin 22.0
    3.Lanoline 10.0
    4.Olive oil 5.0
    5. Chamomile oil 5.0
    6. Palm oil 5.0
    7.borax 0.5
    8. C: Bengal Karatachi extract of Production Example 2
      D: Miracle berry extract of Production Example 2
      F: Lemongrass extract of Production Example 2
      *C ~ FAny one of the extracts 5.0
   9. Achillea millefolium whole plant extract 2.0
     (Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent)
   10.White birch bark extract 2.0
     (Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent)
   11. Ginseng root 50% propylene glycol extract 2.0
   12. Matsuhodo nuclei 50% 1,2-butylene glycol extract 1.0
   13. Soybean seed water extract 1.0
   14. Yeast 50% 1,3-butylene glycol extract 2.0
   15.Liquid shea fat 1.0
   16.Dipotassium glycyrrhizinate 0.1
   17. Antibacterial and antiseptic (Acrinol) 0.1
   18. Perfume (ylang ylang water) appropriate amount
   19.Residue with 100 purified water
[0089]
(Prescription example4) Face wash cream%
    1.Stearic acid 10.0
    2.palmitic acid 10.0
    3.Myristic acid 12.0
    4.Lauric acid 4.0
    5.Glycerin 18.0
    6. dl-Pyrrolidonecarboxylate solution 1.0
    7.Dioctyl adipate1.0
    8.Cetostearyl alcohol 3.0
    9.Triethanolamine 3.0
   10.Ergocalcifer 1
   11.Oleyl alcohol 1.5
   12. Lanolin derivative (E.O. adduct) 1.0
   13.Potassium hydroxide 6.0
   14. C: Bengal Karatachi extract of Production Example 2
      D: Miracle berry extract of Production Example 2
      F: Lemongrass extract of Production Example 2
      *C ~ FAny one of the extracts 3.0
   15. Royal Jelly Extract 1.0
     (Ethanol: 1,3-butylene glycol = 1: 1 extract)
   16. Oil-soluble chamomile flower or leaf extract 1.0
     (Ethanol: 1,3-butylene glycol = 1: 1 extract)
   17. Oil-soluble licorice root or rhizome extract 1.0
     (Ethanol: 1,3-butylene glycol = 1: 1 extract)
   18. Edetate 1.0
   19.Glycyrrhizic acid 1.0
   20.Corn cob grain 0.1
   21.Teutum walnut shell grain 0.1
   22. Antibacterial and antiseptic (photosensitive element 401) 0.1
   23. Fragrance (mugwort water) appropriate amount
   24. The balance of 100 purified water
[0090]
(Prescription example5) Body soap mass%
    1.Potassium laurate 15.0
    2.Potassium myristate 5.0
    3.Propylene glycol 5.0
    4. Bengal Karachi fruit 70% 2,3-butylene glycol extract 3.0
    5. Toki rhizome 70% 2,3-butylene glycol extract 0.5
    6. Kakkon 70% 1,3-butylene glycol extract 0.5
    7. Chlorella 70% 1,3-butylene glycol extract 0.5
    8. Fish (sea bream or flounder) derived hydrolyzed collagen solution 0.5
    9. Plantain whole plant 50% ethanol extract 0.5
   10. Amino acids (glutamine, proline, lysine, etc.) 0.5
  11.Monammonium glycyrrhizinate 0.1
  12. Antibacterial / preservative (undecylenic acid, phenoxyethanol)
   13.pH adjuster
   14. Fragrance (orange water) appropriate amount
   15.Residue with 100 purified water
[0091]
(Prescription example6) Sunscreen cosmetics (O / W type)
    1.Oxybenzone 2.0
    2.Octyl paramethoxycinnamate 5.0
    3.Dihydroxymethoxybenzophenone 0.2
    4.Squalane 10.0
    5.Vaseline 5.0
    6. Stearyl alcohol 3.0
    7.Stearic acid 3.0
    8. Glyceryl monostearate 2.0
    9.Polyethyl acrylate 1.0
   10.1,3-Butylene glycol 6.0
   11. Edetate disodium 0.1
   12.Triethanolamine 1.0
   13.Titanium dioxide 5.0
   14. Lemongrass whole plant 50% ethanol extract 3.0
   15. Gentian whole plant 50% ethanol extract 1.0
   16. Birch bark 70% dipropylene glycol extract 1.0
   17. Cornflower leaf 50% propylene glycol extract 0.5
   18. Kakkon 50% propylene glycol extract 0.5
   19. Palm fruit 50% dipropylene glycol extract 0.5
   20. Antibacterial and antiseptic (benzyl paraoxybenzoate) appropriate amount
   21. Fragrance (jasmine water) appropriate amount
   22.Residue with 100 purified water
[0092]
(Prescription example7) Sunscreen cosmetics (oil type)
    1.liquid paraffin 70.0
    2.Tetrahydroxybenzophenone 1.0
    3.Cetyl octanoate 23.8
    Four. C: Bengal Karatachi extract of Production Example 2
      D: Miracle berry extract of Production Example 2
      F: Lemongrass extract of Production Example 2
      *C ~ FAny one of the extracts 3.0
   5. Chamomile flower 10% 1,3-butylene glycol extract 1.0
   6. Burdock root hot water extract 0.5
   7. Horse chestnut whole plant 30% 1,3-butylene glycol extract 0.5
   8. Mallow flower or leaf 50% propyl alcohol extract 0.5
   9. Whole barley 50% 1,3-butylene glycol extract 0.5
  10. Shark root or leaf hot water extract 0.5
   11.Merirot flower or leaf 70% 1,3-butylene glycol extract 0.5
   12.Ethyl paraaminobenzoate 0.2
   13. Antioxidant (Butylhydroxytoluene)
   14. Perfume (amber perfume) appropriate amount
[0093]
(Prescription example8) Shampoo Mass%
    1.Lauryl sulfate triethanolamine 5.0
    2. Sodium polyoxyethylene lauryl ether sulfate 12.0
    3.1,3-Butylene glycol 4.0
    4.Lauric acid diethanolamide 2.0
    5. Edetate disodium 0.1
    6. C: Bengal Karatachi extract of Production Example 2
      D: Miracle berry extract of Production Example 2
      F: Lemongrass extract of Production Example 2
      *C ~ FAny one of the extracts 3.0
    7. Large-scaled crape myrtle 20% 2,3-butylene glycol extract 2.0
    8.Hyperum root bark or rhizome hot water extract 2.0
    9. Spike or rhizome 30% 1,4-butylene glycol extract 2.0
   10. Toki 30% 1,4-butylene glycol extract 2.0
   11. Tomato fruit hot water extract 1.0
   12.Hydroxypropyl chitosan solution 1.0
   13. Hyaluronic acid solution 1.0
  14.Dipotassium glycyrrhizinate 0.1
   15. Antibacterial and antiseptic (photosensitive element 101) appropriate amount
   16.pH adjusting agent
   17. Perfume (white sand water) appropriate amount
   18. Purified water
[0094]
(Prescription example9) Rinse mass%
    1. Stearyl trimethyl ammonium chloride 3.0
    2.Cetostearyl alcohol 3.0
    3.Polyoxyethylene lanolin ether 3.0
    4.Propylene glycol 5.0
    5.1,2-Pentanediol 2.0
    6. Lemongrass whole plant 50% 1,2-pentanediol extract 5.0
    7. Tokachinka flower 50% 1,3-butylene glycol extract 1.0
    8. Forsythia leaf 50% 2,3-butylene glycol extract 1.0
    9. Perfumed fruit 30% 1,2-butylene glycol extract 1.0
   10. Yellow rhizome 50% 1,3-butylene glycol extract 1.0
   11. Comfrey leaf or stem 50% 1,3-butylene glycol extract 1.0
   12. Soybean seed natto fermentation liquid 0.5
   13.Hydroxyethyl chitosan solution 0.5
   14. Fish (carp or carp) derived collagen solution 0.5
   15. Trehalose solution 0.5
   16. Hydrolyzed silk solution 0.5
   17. Antibacterial / preservative (benzalkonium chloride) appropriate amount
   18. Perfume (boiled water) appropriate amount
   19.Residue with 100 purified water
[0095]
(Prescription example10) Hair Liquid Mass%
    1.Ethanol 29.0
    2.Polyoxypropylene butyl ether phosphate 10.0
    3.Polyoxypropylene monobutyl ether 5.0
    4.Triethanolamine 1.0
    5.1,2-hexanediol 1.0
    6. Miracle fruit 50% 1,2-butylene glycol extract 3.0
    7. Lemongrass leaf 50% 1,3-butylene glycol extract 3.0
    8. Assembly leaf or stem 50% 1,2-butylene glycol extract 1.0
    9. Panax ginseng root hot water extract 1.0
   10. Apple fruit 30% ethanol extract 1.0
   11. Sesamoline 0.3
   12.azulen 1.0
   13. Antibacterial and antiseptic (paraben, benzalkonium chloride) appropriate amount
   14. Fragrance (orange water) appropriate amount
   15.Residue with 100 purified water
[0096]
(Prescription example11) Hair Liquid Mass%
    1.Ethanol 40.0
    2.Ethyl oleate 1.0
    3.Polyoxyethylene (40) hydrogenated castor oil 2.0
    Four. C: Bengal Karatachi extract of Production Example 2
      D: Miracle berry extract of Production Example 2
      F: Lemongrass extract of Production Example 2
      *C ~ FAny one of the extracts 6.0
    5. Comfrey leaf or stem 50% ethanol extract 1.0
    6. Palm fruit or leaf 50% ethanol extract 1.0
    7. Soybean seed natto fermentation liquid 1.0
    8. Hamelis leaf or stem hot water extract 1.0
    9. Comfrey leaf or stem 50% ethanol extract 1.0
   10. Persimmon leaf 30% ethanol extract 1.0
   11. Lettuce leaf 50% ethanol extract 1.0
   12.Carpronium chloride 0.3
   13. Pantethine aqueous solution 0.3
   14.Amino acids or their derivatives 3.0
    (Lysine, alanine, pyrrolidone carboxylic acid, etc.)
   15. Antibacterial and antiseptic (paraben, benzalkonium chloride) appropriate amount
   16. Perfume (rose water) appropriate amount
   17.Residue with 100 purified water
[0097]
(Prescription example12) Hair artnic mass%
    1. l-Menthol 0.2
    2.Ethanol 32.5
    3.Polyoxyethylene hydrogenated castor oil 0.5
    4.Propylene glycol 5.0
    5.Diphenhydramine hydrochloride 0.3
    6. C: Bengal Karatachi extract of Production Example 2
      D: Miracle berry extract of Production Example 2
      F: Lemongrass extract of Production Example 2
      *C ~ FAny one of the extracts 3.0
    7. Hypericum fruit or pericarp hot water extract 1.0
    8. Western bodhi tree flower or leaf 50% propylene glycol extract 1.0
    9. Lavender flower or flower ear hot water extract 1.0
   10. Belode mallow rhizome or root bark 50% ethanol extract 1.0
   11. Ogon rhizome or root bark 50% ethanol extract 1.0
   12. Soybean seed hot water extract 1.0
   13.Carboxymethylchitin solution 1.0
   14 Chicken crown extract solution 0.2
   15.Pantethine aqueous solution 0.2
   16. Antibacterial / preservative (phenoxyethanol)
   17. Perfume (rose water) appropriate amount
   18.Residual water 100
[0098]
(Prescription example13) Hair growth and hair nourishing agent mass%
    1.Ethanol 60.0
    2. Bengal Karachi fruit 50% glycerin extract 5.0
    3. Allergen 50% propylene glycol extract 2.0
    4. Vitamin E derivative 0.5
    5.Pepper tincture 0.5
    6.Resorcin 0.5
    7.Dipotassium glycyrrhizinate 0.5
    8.Carboxymethylchitin solution 0.5
    9. Collagen protein enzyme solution 1.0
   10.Pig hematin solution 0.5
   11. Porcine mucin solution 0.5
   12. Amino acids (Arginine, Glycine, Glutamine, etc.) 0.5
   13. Antibacterial and antiseptic (paraben) 0.1
   14. Fragrance (rosemary water)
   15.Residue with 100 purified water
[0099]
(Prescription example14) Hair growth and hair nourishing agent mass%
    1.Ethanol 60.0
    2. C: Bengal Karatachi extract of Production Example 2
      D: Miracle berry extract of Production Example 2
      F: Lemongrass extract of Production Example 2
      *C ~ FAny one of the extracts 3.0
    3.Hyperum root bark or rhizome hot water extract 3.0
    4. Whole plant 60% ethanol extract 3.0
    5. Peony rhizome or root bark 60% ethanol extract 3.0
    6. Artemisia leaf or stem 50% 1,3-butylene glycol extract 1.0
    7. Soybean seed natto fermentation liquid 1.0
    8. 20% 2,3-butyleneglycol extract from the plant
    9. Hot pepper fruit hot water extract 1.0
   10. Cantalis tincture 0.5
   11. Pantothenic acid derivative 0.2
   12.β-Glycyrrhetinic acid 0.2
   13.Resorcin 0.2
   14.Hydroxyethyl chitosan solution 0.2
   15.Elastin hydrolyzate 0.2
   16.Keratin protein enzymatic solution 0.2
   17. Preservative (paraben) 0.1
   18. Perfume (bergamot water) appropriate amount
   19.Residue with 100 purified water
[0100]
(Prescription example15) Granule bath agent Mass%
    1.Sodium bicarbonate 58.0
    2.Anhydrous sodium sulfate 30.0
    3. Borax 5.0
    Four. C: Bengal Karatachi extract dry powder of Production Example 1
      D: Miracle berry extract dried powder of Production Example 1
      F: Lemongrass extract dried powder of Production Example 1
      *C ~ FAny one of the extract dry powder 3.0
    5. Sorbitol 1.0
    6. Peach leaf 70% ethanol extract dry powder 1.0
    7. Black tea leaf 30% ethanol extract dry powder 1.0
    8. Mulberry white skin hot water extraction dry powder 1.0
    9. Pigment (Gunjo green) appropriate amount
[0101]
(Prescription example16) Mouth freshener mass%
    1.Ethanol 20.0
    2.Glycerin 15.0
    3. Polyoxyethylene hydrogenated castor oil 1.0
    4.Saccharin 0.2
    5.Chlorohexidine 0.01
    6. C: Bengal Karachi fruit or pericarp hot water extract
      D: Miracle berry whole plant hot water extract
      F: Whole lemongrass hot water extract
      *C ~ FAny one of the extracts 3.0
    7. Hypericum leaf or stem hot water extract 1.0
    8. Grapefruit fruit or leaf hot water extract 1.0
    9.Green tea leaf hot water extract dry powder 0.1
   10. Pigment (Gunjo green) appropriate amount
   11. Residue with 100 purified water
[0102]
(Prescription example17) Tableware detergent mass%
    1. Alkyl (C12) glucoside 20.0
    2. Polyoxyethylene (3) dodecyl ether sulfate Na 10.0
    3.Glycerin 2.0
    4.Ethanol 5.0
    5. Lemongrass leaf or stem hot water extract 3.0
    6.Hyperum root bark hot water extract dry powder 1.5
    7. Sandalwood whole plant 50% dipropylene glycol extract 0.5
    8. Residue with 100 purified water
[0103]
【The invention's effect】
  Of the present inventionBengal Karachi fruit, Bengal Karachi fruit peel, Bengal Karachi seed, Miracle berryContains one or more plant extracts selected fromActive oxygen scavengerWas confirmed to have an active oxygen scavenging action.Effective in preventing skin and scalp aging.The present invention can be used for other general foods and drinks.
[Brief description of the drawings]
FIG. 1 of the present inventionBengal Karachi, Miracle Berry, LemongrassIt is a figure which shows the active oxygen scavenging effect of various plant extracts.

Claims (1)

A reactive oxygen scavenger comprising at least one plant extract selected from Bengal Karachi fruit, Bengal Karachi fruit skin, Bengal Karachi seed, and Miracle berry .

Images