JP3454385B2 - Method for producing O / W type skin cream - Google Patents

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention relates to a method for producing an O / W type skin cream. The present invention avoids oxidization / decomposition that occurs in the high temperature dissolution treatment step of the oil phase component, in addition to the heat treatment of vitamin preparations, etc., when producing an O / W type skin cream from the oil phase component and the water phase component. Manufacturing to provide a good quality O / W type skin cream that is contained in the product without oxidization, decomposition, deterioration, etc. of the raw material components while avoiding the deterioration of the unstable additive components. Regarding the method.

[0002]

BACKGROUND OF THE INVENTION Skin creams are a particularly common dosage form in basic cosmetics and have been widely used for a long time. These creams are a type of emulsion in which one of two liquids, such as water and oil, which do not dissolve in each other, is used as a dispersed phase and dispersed in the other dispersion medium in a stable state. Therefore, since the stability can be widened, there is an advantage that various components can be blended. In addition, since oil, moisturizer and water can be blended in a wide range of ratios, as a cosmetic suitable for mainly supplying water, moisturizer, and oil in order to maintain the moisture balance of the skin, further moisturizing the skin,
Various types of cosmetics suitable for imparting a softening function are manufactured. The cream is
Because it is easy to use and easy to apply uniformly, and because it is possible to take a wide range of prescriptions as described above,
For example, even if it is used, it is refreshing or oily, moist, moist, hard, soft, easily spreads, quickly adapts to your skin, easily wiped off with your hands, and makeup once. Then, it can be made to have various properties such as hard-to-remove, washable, etc., and the skin quality and condition, makeup habits that differ depending on the season, the age of the user, and the living environment. It is a highly useful dosage form that can be easily manufactured according to the purpose of use depending on the difference in taste and the preference. Thus, skin creams that can be used for various purposes are important in fulfilling the original beauty of cosmetics, which is the original purpose, and in fulfilling the role of maintaining the beauty.

At present, with the progress of understanding of the living body, the importance of its physiological function has been recognized in understanding the role of the skin and the like. The skin acts as a buffer so that mechanical action from the outside does not directly reach the inside of the body, and also acts to protect the human body from chemical irritation and action. In addition to such a protective effect, the skin is also responsible for regulating body temperature and various other effects. It has been found that beautiful skin has a well-balanced function and action as described above, a proper balance of water and oil, and is fresh and shiny. In this way, as one of the properties that cream, which is one of the cosmetics for keeping the skin more beautiful, should have the property of being outside the stratum corneum of this skin and controlling the moisture content of this stratum corneum, even though it is an extremely thin film. Recognize that it is important to emulate the function of the sebaceous membrane, which plays various roles such as stimulating or attacking the skin, protect the skin from dirt, and help the function. It has come to be done. By the way, it has been known that sebum in this sebum film contains squalene, cholesterol ester, cholesterol, wax, triglyceride, diglyceride, monoglyceride, fatty acid, etc. It has been found that there are lipoproteins, polypeptides, lipopolysaccharides, sphingolipids, glycerides, phospholipids and the like.

[0004] In addition, the properties of the cream are required to prevent hyperkeratosis of the skin and also to help the sebum membrane covering the stratum corneum in order to keep the skin fresh. There is. As a cream having such a function, a natural moisturizing factor (N
Replenishing substances that are similar to MF = Natural Moisture Factor, or replenishing substances that prevent NMF from spilling and disappearing, or providing substances that help these functions. Is also required. By the way, as NMF, glycolipids, phospholipids, amino acids, etc. have been known so far. Among them, particularly important components are amino acids, pyrrolidonecarboxylic acid (PCA), lactate, urea, glucosamine, creatine, citric acid. It is said that organic acids, peptides, sodium, potassium, calcium, magnesium, etc., and keratin in the stratum corneum of the skin work together to contribute to water retention. The skin cream that is required to have such a function and action is such that squalene, cholesterol ester, cholesterol, wax, triglyceride, diglyceride, monoglyceride, a component of sebum such as fatty acid is added as a component to be used, Alternatively, it has come to be used with a property very similar to that, and in the production thereof, it is produced by emulsifying the water phase component and the oil phase component. For example, a typical cream manufacturing process is as shown in FIG.

By the way, in this emulsification treatment, both the water phase component and the oil phase component must be uniformly dissolved. Each of the ingredients must be heat-dissolved so that they can be mixed or dissolved uniformly. And as described above, in order to impart the required function and action, the water phase and the oil phase must have a certain amount of a specific component, but at the same time, such a component must be emulsified with each other without heat treatment. It cannot be dissolved and mixed uniformly so that it can be used for processing. In particular, what is used as the oil phase component is a solid component at room temperature and must be heated to a high temperature or heated for a long time in order to uniformly mix or dissolve them. In this way, the heating and dissolution treatment step cannot be omitted, but some of the components are oxidized or decomposed when they are heated to a high temperature or heated for a long time, and they change to their original properties. Or the desired function is lost,
Furthermore, there is a problem that it turns into a harmful substance. As described above, many of the components having preferable properties as the components of the skin cream, particularly those used as the oil phase component, are sensitive to heat, and therefore, irritants are generated by heating or On the other hand, there is also a problem that an unstable component cannot be blended or that an antioxidant which is unstable after heat treatment must be added to prevent deterioration.

In the cream used for keeping the skin and the skin as described above, there are restrictions on the components to be added for that purpose, or unfavorable components such as antioxidants must be added. It is necessary to avoid causing allergic problems by altering some components due to the heat treatment. Conventionally, it is heated to 70 ° C or higher, and generally 80
Since it is heated up to ℃ or more, and the emulsification process is performed while maintaining the temperature at 70 ℃ or more, an irritant is generated during the process, or an antioxidant is added to suppress the irritant as much as possible. Had to add. Further, the additives such as the antioxidant added in this manner may cause further stimulants during the heat treatment at 70 ° C. or higher, or may cause a problem in the product once obtained. By the way, generally, the boiling point of a liquid is known to be able to easily lower the temperature of the boiling point by reducing the pressure of the environment surrounding the liquid, but in the case of solids, semi-solids, solid mixtures, etc. It has been theoretically pointed out that even if the pressure is reduced, a decrease in the melting temperature cannot be expected. It is considered that it is theoretically impossible to lower the melting temperature, since the solid oil is used as the raw material oil component of the skin cream.

[0007]

Means for Solving the Problems The present inventors have solved the above-mentioned problems by a simple method, avoiding the use of ingredients that are less restricted in their components and are not preferable for the skin, and use them for a long period of time. However, it is not harmful, and the skin is hypersensitivity, and if a normal cream is used, the skin will be irritated and it will be irritated. As a result of research and development, the present invention has been completed. That is,
In the present invention, when an O / W type skin cream is produced from an oil phase component and an aqueous phase component, the oil phase component is treated in an inert atmosphere.
In a vacuum and for the production of normal O / W type skin cream
A temperature of 40 ° C. to 65 ° C., which is lower than that in the case of mixing and dissolving, and then mixing the oil phase component and the aqueous phase component obtained by the treatment in this way, and emulsifying at a low temperature. / W-type skin cream manufacturing method. In addition, the present invention uses the oil phase component and the water phase component to
In producing a / W type skin cream, the oil phase components are mixed and dissolved at a low temperature under reduced pressure, and then the oil phase component and the water phase component obtained by the treatment are mixed and emulsified. The present invention provides a method for producing an O / W type skin cream, which is characterized in that it is carried out at a temperature that is significantly lower than the conventional temperature such as low temperature and reduced pressure. According to the present invention, when an O / W type skin cream is produced from an oil phase component and an aqueous phase component, the oil phase component is mixed and dissolved under reduced pressure at a low temperature, and then the oil thus obtained is treated. A fragrance and other components are added to the phase components as needed, and mixed, and the oil phase mixed component thus obtained and the aqueous phase component are mixed and emulsified under reduced pressure and low temperature, and then obtained in this way. O is characterized in that the product is mixed with a heat labile component as required.
It also provides a method for producing a / W type skin cream. In the present invention, the mixing / dissolving treatment step of the oil phase component is carried out at a temperature substantially lower than that in the mixing / dissolving treatment step of the oil phase component in the usual O / W type skin cream production. The term “substantially lower temperature” is performed under reduced pressure, for example. This low-temperature mixed dissolution treatment step under reduced pressure means that the treatment is performed under a temperature substantially lower than that in the usual O / W type skin cream production and under a pressure sufficient to achieve a substantially low temperature. means. Note that this processing step is performed under an inert atmosphere, and can be performed , for example, in a nitrogen stream. The mixing and dissolution treatment step of the oil phase components can be performed under a nitrogen atmosphere under substantially reduced pressure, and is substantially performed at a lower temperature.

In the present invention, the step of mixing and dissolving the oil phase components is carried out at about 40 ° C. to about 65 ° C., preferably about 45 ° C. to about 60 ° C., more preferably about 5 ° C.
It is performed at 0 ° C to about 59 ° C. Of course, normal O / W
When using a raw material in which the mixing and dissolving treatment step of the oil phase component in the production of the skin cream for skin must be performed at a temperature of about 80 ° C. or higher, the mixing and dissolving treatment step of the oil phase component is It need only be at a temperature that is substantially low enough, and does not necessarily have to be about 65 ° C or lower. The mixed dissolution treatment step of the oil phase component in the present invention is carried out, for example, under reduced pressure at about 50 ° C to about 64 ° C, preferably about 50 ° C to about 60 ° C, and more preferably about 50 ° C to about 59 ° C. It can be carried out at 0 ° C, even more preferably at about 58 ° C or lower. In the case of using a raw material in which the mixing / dissolving treatment step of the oil phase component in the usual O / W type skin cream production must be performed at a temperature of about 70 ° C. or higher, mixing of the oil phase component is used. The dissolution treatment step is performed under reduced pressure at about 40 ° C to about 60 ° C, preferably about 45 ° C.
C. to about 59.degree. C., more preferably about 50.degree. C. to about 58.degree. What is under reduced pressure is
In a broad sense, it is lower than the normal pressure, but may be under a pressure of, for example, about 0 to about 300 mmHg,
A narrow range may be under a pressure of about 0 to about 200 mmHg, preferably about 0 to about 100 mmHg.
More preferably from about 0 to about 5
It may be under a pressure of 0 mmHg, and even more preferably under a pressure of about 0 to about 10 mmHg. In the present invention, the mixed dissolution treatment step of the oil phase component can be performed at a temperature of about 50 ° C to about 60 ° C under a pressure of about 0 to about 200 mmHg.

In the present invention, the emulsification treatment step is carried out at a low temperature. In this case, the emulsification treatment step at a low temperature can mean that the emulsification treatment step is performed at a temperature substantially lower than that in the usual O / W type skin cream production. In the present invention, the emulsification treatment step may be performed under low temperature and reduced pressure. Further, in this case, the emulsification treatment step under low temperature and reduced pressure is performed under a temperature substantially lower than that in the usual O / W type skin cream production and under a pressure sufficient to achieve a substantially lower temperature. May mean that. This treatment step can be performed under an inert atmosphere, for example, in a nitrogen stream. This emulsification treatment step can be performed under a nitrogen atmosphere under a substantially reduced pressure, and it is also preferable to perform it under a substantially lower temperature.
In the emulsification process, the oil phase component can be gradually added to the agitated water phase component, or the oil phase component can be agitated and gradually added to the water phase component. . This treatment step can be performed under an inert atmosphere, for example, in a nitrogen stream.
The reduced pressure in the emulsification treatment step under the reduced pressure at low temperature refers to a pressure lower than the normal pressure in a broad sense, but is about 0, for example.
To about 300 mmHg, and a narrow range of about 0 to about 200 mmHg, preferably about 0 to about 100 mmHg, and more preferably about 0 to about 100 mmHg. About 50 mmH
It may be under a pressure of g, and even more preferably under a pressure of about 0 to about 10 mmHg. In the present invention, the emulsification treatment step is about 0 to about 200 mmH.
It can be carried out at about 50 ° C. to about 60 ° C. under a pressure of g. In the present invention, the low temperature of the emulsification treatment step at a low temperature may be about 40 ° C. to about 65 ° C., preferably about 45 ° C. to about 60 ° C., and more preferably about 50 ° C. It may be about 59 ° C. Needless to say, when a raw material is used in which the emulsification treatment step in the usual production of O / W type skin cream must be carried out at a temperature of about 80 ° C. or higher, the temperature should be substantially lower than that. It does not have to be about 65 ° C. or lower, for example,
It can be carried out under reduced pressure at about 50 ° C. to about 69 ° C., but is preferably carried out at a lower temperature. Further, the emulsification treatment step at a low temperature can be carried out at about 50 ° C. to about 59 ° C., but it is preferably carried out at a lower temperature. It is preferably carried out at about 50 ° C. to about 58 ° C., more preferably about 57 ° C. or less. Further, when using a raw material for which the emulsification treatment step in the usual O / W type skin cream production must be carried out at a temperature of about 70 ° C. or higher,
The emulsification step at low temperature may be performed at about 40 ° C to about 60 ° C, preferably about 45 ° C to about 59 ° C, and more preferably about 50 ° C to about 58 ° C. Further, in the present invention, it is preferable that the mixing and dissolution treatment step of the oil phase components is continuously performed at a low temperature from the end of the emulsification treatment step. In this case, the low temperature treatment step can mean that the treatment is performed at a temperature substantially lower than that in the usual O / W type skin cream production. In the present invention, these treatment steps may be carried out under low temperature and reduced pressure, and preferably,
It is carried out at low temperature under reduced pressure. In this case, the low temperature reduced pressure treatment step means that the treatment is performed under a temperature substantially lower than that in the usual O / W type skin cream production and under a pressure sufficient to achieve a substantially lower temperature. May be. In the present invention, these processing steps can be carried out at a pressure of about 0 to about 200 mmHg and at a temperature of about 50 ° C to about 60 ° C.

In the present invention, the emulsification treatment step is performed under reduced pressure at about 40 ° C. to about 65 ° C., preferably at about 50 ° C. to about 60 ° C. under about 0 to about 300 mmHg, and more preferably. It can be carried out at a pressure of about 0 to about 200 mmHg at about 50 ° C. to about 60 ° C., more preferably at a pressure of about 0 to about 100 mmHg and at a lower temperature. In particular, a pressure of about 0 to about 10 mmHg is also included. In the present invention, the emulsification treatment step is performed by, for example, a homomixer. In the present invention, a preliminary emulsification treatment step may be provided before the emulsification step, and the preliminary emulsification treatment step can be performed in the same manner as in the usual O / W type skin cream production, but at a low temperature. You can also do it. In this case, the low temperature pre-emulsification treatment step means that the pre-emulsification treatment step is performed at a temperature substantially lower than in the usual O / W type skin cream production, and the substantially lower temperature means, for example, , May be performed under reduced pressure. In the pre-emulsification process,
The oil phase component can be added to the gradually stirring aqueous phase component, or conversely, the aqueous phase component can be added to the gradually stirring oil phase component. This treatment step can be carried out under an inert atmosphere, for example:
It can be performed in a nitrogen stream. This pre-emulsification step is conducted under a pressure of about 0 to about 500 mmHg, preferably about 0 to about 200 mmHg, more preferably about 0 to about 100 mmHg, and even more It can be carried out preferably under a pressure of about 0 to about 10 mmHg.

In the present invention, the pre-emulsification step is
It can be performed at about 40 ° C to about 65 ° C, preferably at about 45 ° C to about 60 ° C, more preferably at about 50 ° C to about 59 ° C. Of course, normal O /
When a pre-emulsification step in the production of W-type skin cream uses a raw material which must be performed at a temperature of about 80 ° C. or higher, it should be performed at a temperature substantially lower than that. It does not necessarily have to be about 65 ° C. or lower, and for example, it can be carried out under reduced pressure at about 50 ° C. to about 69 ° C., but it is preferably carried out at a lower temperature. The low temperature pre-emulsification process is
It is carried out at about 50 ° C. to about 64 ° C., preferably about 50 ° C. to about 60 ° C., more preferably about 59 ° C. or less. Further, when using a raw material in which the pre-emulsification step in the usual O / W type skin cream production must be performed at a temperature of about 70 ° C. or higher, the low-temperature pre-emulsification step is 40 ° C to about 5
It is carried out at 9 ° C., preferably at about 45 ° C. to about 58 ° C., more preferably at about 50 ° C. to about 57 ° C. In the present invention, the pre-emulsification step is performed under reduced pressure at about 40 ° C to about 65 ° C, preferably about 0 to about 5 ° C.
It is performed at about 50 ° C. to about 60 ° C. under 00 mmHg, more preferably at about 50 ° C. to about 59 ° C. under a pressure of about 0 to about 200 mmHg, and even more preferably at a pressure of about 0 to about 10 mmHg. Can be performed at lower temperatures. In the present invention, a heat-unstable component can be added and mixed after the emulsification process, and this is preferably performed at a low temperature. In this case, the addition and mixing treatment may be performed at a temperature substantially lower than that in the usual O / W type skin cream production, and this substantially lower temperature is performed under reduced pressure, for example. The treatment may be carried out at a temperature that does not adversely affect the heat-labile compounding ingredients such as the following agents and moisturizing factors.
This treatment step can be performed under an inert atmosphere, for example, in a nitrogen stream.

In the present invention, this blending treatment step is
Performed at about 10 ° C to 60 ° C, preferably about 20 ° C to 55 ° C, more preferably about 30 ° C to about 50 ° C.
And more preferably at about 35 ° C to about 45 ° C. Further, in the present invention, this blending treatment step can be performed under normal pressure, but in some cases, can be performed under reduced pressure. The compounding process step is performed under a pressure of about 0 to about 760 mmHg and is about 0 to about 50.
It can be performed under a pressure of 0 mmHg, further under a pressure of about 0 to about 300 mmHg, and further under a pressure of about 0 to about 200 mmHg. In the present invention, this blending treatment step is carried out at about 10 ° C to 60 ° C under normal pressure, preferably about 20 ° C to 55 ° C under normal pressure, more preferably about 30 ° C to about 50 ° C under normal pressure. It is performed at about 35 ° C. to about 45 ° C. under normal pressure. This compounding step can be carried out under reduced pressure at about 20 ° C. to 60 ° C., particularly when dealing with heat labile substances, and further at about 20 ° C. to 60 ° C. under about 0 to about 500 mmHg, preferably Is performed at about 20 to 55 ° C. under about 0 to about 300 mmHg, more preferably about 0 to about 200 mm
It is carried out at about 20 ° C. to about 50 ° C. under a pressure of Hg, more preferably about 20 to about 100 mmHg.
It can also be carried out at a temperature of from 0 to 45 ° C.

In the present invention, a fragrance and other components can be added and mixed, if necessary, following the mixing and dissolving treatment of the oil phase components, and a surfactant, a fragrance, a preservative, a coloring agent, a moisturizing agent, and a drug. Those selected from the group consisting of can be added to and mixed with the oil phase component according to the purpose. Further, in the present invention, during the emulsification treatment or subsequent to the emulsification treatment, a fragrance and other components can be added and mixed as required, and a surfactant, a fragrance, a preservative, a coloring agent, a moisturizer, and a drug. Those selected from the group consisting of can be added and mixed according to the purpose. As described above, in the present invention, a vitamin or a physiologically active substance may be added to carry out a compounding treatment in the emulsification treatment or subsequent to the emulsification treatment. The vitamins or physiologically active substances include those that are relatively unstable or extremely unstable to heat among the agents that can be added below, and one of the natural moisturizing factors or a function similar to it. There are also things to do. For example, glycerol, sorbitol, lactate, a substance that acts as a humectant such as pyrrolidonecarboxylate to help the stratum corneum retain water, a lactic acid bacterium fermentation product, a bifidobacteria fermentation product, sophorolipid, a mitochondrial component, Yeast culture products, sophorolivid modified derivatives, Streptococcus
Hyaluronic acid obtained from Zoovidemics, Shikonin obtained from cell culture, etc.
Examples thereof include chitin obtained from crustaceans such as shrimp, chitosan, a tyrosinase inhibitor derived from mushrooms, bio γ-linolenic acid produced using a filamentous fungus Mortierella isaverina, hydrolyzed collagen, β-cyclodextrin and the like.

As described above, some of these vitamins or physiologically active substances can be mixed before being added in the emulsification treatment step. This mixing treatment can be performed in the same manner as in the usual production of O / W type skin cream, but can also be performed at a low temperature. In this case, the mixing treatment step at a low temperature means a normal O /
It means that the treatment is performed under a temperature substantially lower than that in the W-type skin cream production, and the substantially lower temperature may mean, for example, that performed under reduced pressure. This treatment step can be performed under an inert atmosphere, for example, in a nitrogen stream. In the present invention, this mixing process step is performed at about 10 ° C to 65 ° C.
At about 20 ° C. to about 60 ° C., more preferably at about 30 ° C. to about 50 ° C., and even more preferably at about 35 ° C. to about 45 ° C. Further, in the present invention, the mixing treatment step is preferably carried out under normal pressure, but it may be carried out under reduced pressure in some cases. At this reduced pressure, this mixing process step is performed at about 0 to about 500 mmHg, or about 0 to about 300 mmHg.
Under mmHg, further from about 0 to about 200 mmHg
And especially about 0 to about 100 mm Hg. This mixing process step is performed under reduced pressure at about 10 ° C to 60 ° C, especially when dealing with heat labile substances,
It is preferably carried out at about 10 to about 55 ° C. under about 0 to about 500 mmHg, more preferably about 0 to about 300.
It can also be performed at a temperature of about 10 ° C. to about 54 ° C. under a pressure of mmHg. More preferably about 0 to about 100 mmH
It can also be carried out at a pressure of g from about 10 ° C to about 53 ° C.

In the present invention, the process of mixing the oil phase component with the fragrance and other components can be carried out in the same manner as in the usual production of O / W type skin cream.
It can also be performed at low temperature. In this case, the mixing treatment step of the low temperature oil phase component, the fragrance, and the other components is the same as usual O.
/ W type skin cream means that the treatment is performed at a temperature substantially lower than that in the production of the skin cream, and the substantially lower temperature may mean that the treatment is performed under reduced pressure, for example. This treatment step can be performed under an inert atmosphere, for example, in a nitrogen stream. In the present invention, the mixing treatment step of the oil phase component with the fragrance and other components can be carried out at about 40 ° C to about 65 ° C, preferably about 45 ° C to about 60 ° C, and more preferably It can be performed at about 50 ° C to about 58 ° C. Of course, in the usual O / W type skin cream production, the mixing treatment step of the oil phase component, the fragrance and other components is about 80.
When using a raw material that must be performed at a temperature of ℃ or higher, low temperature oil phase components and fragrance,
The mixing treatment step with other components may be carried out at a temperature substantially lower than that, and does not necessarily have to be about 65 ° C. or lower, for example, under reduced pressure from about 50 ° C. to about 50 ° C. It can be carried out at 69 ° C, but is preferably carried out at a lower temperature. For example, from about 50 ℃ to about 64
It can be performed at about 50 ° C., but can be performed at about 50 ° C. to about 60 ° C., preferably at about 50 ° C. to about 59 ° C., and even more preferably at about 58 ° C. or lower. Further, in the case of using a raw material in which the mixing treatment step of the oil phase component, the fragrance and other components in the usual O / W type skin cream production must be carried out at a temperature of about 70 ° C. or higher, The mixing treatment step of the oil phase component and the fragrance under low temperature is performed at about 40 ° C to about 60 ° C, preferably about 45 ° C to about 59 ° C, more preferably about 50 ° C to about 58 ° C. To do.

In the present invention, the reduced pressure in the mixing process of the oil phase component and the perfume may be any as long as a substantially lower temperature can be achieved, for example, from about 0 to about 500.
mmHg, or about 0 to about 300 mm
Hg, preferably about 0 to about 200 mmH
g, more preferably about 0 to about 100 m
It may be under a pressure of mHg, and even more preferably under a pressure of about 0 to about 50 mmHg. In the pre-emulsification treatment, it is possible to generally perform the pre-emulsification with a paddle type stirrer, but in the pre-emulsification treatment, it is better to use a high-speed homomixer to obtain better results. Further, in the main emulsification treatment, a better result can be obtained by using a high speed homomixer. As the emulsifying device, there is an open type, but a closed type is preferably used for producing a product in a mixed state of air or aseptic condition. Examples of the open type emulsifying device include a device having a paddle type stirrer and a device having a propeller type stirrer. Examples of the closed emulsification device include those equipped with a homomixer (high-speed stirrer). As an emulsifying device, there is also a type in which a paddle type stirrer and a homomixer (high speed stirrer) are combined. The emulsification treatment can be carried out by using these emulsifiers with a mixer treatment, a colloid mill treatment, a homogenizer treatment and an ultrasonic treatment. In a homomixer or the like, the rotation is performed at 1000 to 20000 rpm, preferably 2000 to 4000 rpm, and more preferably 2500 to 3500 rpm. For example, pre-emulsification treatment, using a homomixer,
Rotation of 1000 to 20000 rpm, preferably 200
Rotation of 0 to 4000 rpm, more preferably 2500
It is performed by giving a rotation of 3500 rpm. For example, the emulsification treatment is performed using a homomixer at 1000 to 20000.
rpm, preferably 2000 to 4000 rpm, more preferably 2500 to 3500 rpm.

The cream obtained as described above is subjected to usual treatment to obtain a product. For example, the product obtained by the emulsification treatment is subjected to deaeration treatment, filtration treatment, cooling treatment and the like, stored, and further filled in a container. Examples of the oil phase component used in the present invention include solid oil components, semi-solid oil components, fluid oil components and surfactants.
Further, the oil phase component of the present invention may further contain one selected from the group consisting of a surfactant, a perfume, a preservative, a coloring agent, a moisturizer, and a drug. Typical oil phase components of the present invention include, for example, fatty acids, higher alcohols,
Examples thereof include fatty acid esters, oils and fats, waxes, and surfactants.

Specific examples of the oil component of the oil phase component include:
Squalane, liquid paraffin, paraffin, petrolatum,
Hydrocarbons such as solid paraffin, microcrystalline wax, ceresin, olive oil, camellia oil, almond oil, cocoa butter, jojoba oil, macadamia nut oil,
Avocado oil, hydrogenated palm oil, coconut oil, castor oil, sesame oil, sunflower oil, peanut oil, evening primrose oil, oils and fats such as synthetic triglyceride, beeswax, lanolin, hydrogenated lanolin, waxes such as carnauba wax, candelilla wax, stearin Fatty acids such as acids, oleic acid, linoleic acid, isostearic acid, myristic acid, palmitic acid, palmitoleic acid, ricinoleic acid, lauric acid, behenic acid, cetanol, isocetyl alcohol, stearyl alcohol, isostearyl alcohol, behenyl alcohol, hexadecyl Higher alcohols such as alcohol, octyldodecyl alcohol, oleyl alcohol and cholesterol, cetyl isooctanoate, butyl stearate, isocetyl stearate, isopropyl isostearate, Cystine isopropyl, 2-octyldodecyl myristate, isobutyl palmitate,
Hexadecyl adipate, cetyl 2-ethylhexanoate, diisostearyl malate, ceryl 16-hydroxypalmitate, ceryl palmitate, myricyl palmitate, cetyl palmitate, isopropyl laurate, hexyl laurate, glyceryl monoricinoleate. , Decyl oleate, di-n-butyl sebacate,
Synthetic esters such as glycerol tri-2-ethylhexanoic acid ester, glycerin triester, pentaerythritol tetraester and cholesteryl ester, silicone oils such as methylpolysiloxane, dimethylpolysiloxane, methylphenylpolysiloxane and cyclomethicone, polyoxypropylene Examples include adducts. These can be used without any limitation as long as they are in accordance with the purpose and intent of the present invention. In particular, when silicone oils such as methylpolysiloxane are blended, it is difficult to carry out the dissolution treatment at a lower temperature under a slight reduced pressure condition. It is preferable to carry out mixed dissolution treatment.

Specific examples of the surfactant include glycerin monooleate, glycerin monostearate and the like, glycerol ester such as diglycerol dioleate, and triglyceryl ester such as glyceryl trioctanoate. , Trimethylol lopan ester, pentaerythritol ester, sorbitol ester, sucrose fatty acid ester and other sucrose ester, polyoxyethylene (P
OE) (20) sorbitan monolaurate, P
OE (20) sorbitan monostearate, P
OE (20) POE sorbitan fatty acid ester such as sorbitan monooleate ester, sorbitan ester such as sorbitan fatty acid ester, POE (20) cetyl alcohol ether, POE glycerol fatty acid ester such as POE glycerol triisostearate ester, POE (25) POE alkyl ethers such as cetyl alcohol ether, propylene glycol monostearate esters, POE / POP block polymers, non-ionic ones such as POE hardened castor oil ester, fatty acid soaps, anionic ones such as sodium alkylsulfate, alginic acid Sodium, starch derivatives, tragacanth gum, lecithin, phosphatidylserine, phosphatidylethanolamine, phosphatidylcholine, etc. . These can be used without any limitation as long as they are in accordance with the purpose and intent of the present invention.

Specific examples of typical combinations of oil phase components used in the present invention include those containing stearic acid, stearyl alcohol, and butyl stearate, stearic acid, stearyl alcohol, hydrogenated lanolin, squalane, and octyl. Containing dodecyl alcohol, containing cetanol, stearic acid, petrolatum, squalane, and glycerol tri-2-ethylhexanoic acid ester, solid paraffin, beeswax, petrolatum, and containing liquid paraffin, stearic acid, cetanol, petrolatum, liquid Paraffins and those containing isopropyl myristate, microcrystalline wax, solid paraffin, beeswax, petrolatum, hydrogenated lanolin, squalane, and those containing hexadecyl adipate, squas Orchid, stearic acid, behenyl alcohol, octyldodecyl alcohol, glyceryl trioctanoate, POE (20) sorbitan monostearate, sorbitan monostearate, lipophilic glyceryl monostearate, avocado oil,
Those containing methylpolysiloxane, concentrated glycerin, and 1,3-butylene glycol, squalane, behenyl alcohol, self-emulsifying glyceryl monostearate, octyldodecyl alcohol, lecithin, avocado oil, sesame oil, olive oil, and concentrated glycerin. Can be mentioned. For formulations that lack methyl polysiloxane, etc.,
It is also recognized that the manufacturing process can be performed at a lower temperature, which is preferable. Further, in the oil phase component, an oil-soluble fragrance, a moisturizer, an oil-soluble mucilage substance, an oil-soluble coloring agent, an oil-soluble drug, etc. may be added, as appropriate. In particular, the humectant can be preferably blended in the oil phase component. These can be used without any limitation as long as they are in accordance with the purpose and intent of the present invention.

As the fragrances, natural fragrances such as plant fragrances obtained from plants and animal fragrances obtained from the glandular sac of animals, those isolated from natural fragrances and those chemically synthesized based on them And synthetic flavors such as blended natural flavors and synthetic flavors. Specific examples of natural flavors include animal flavors such as musk, civet, catrium, and ambergris, rose oil,
Jasmine oil, neroli oil, lavender oil, ylang-ylang oil, tuberose oil, clary sage oil, clove oil, peppermint oil, geranium oil, patchouli oil, sandalwood oil, cinnamon oil, coriander oil, nutmeg oil, pepper oil, lemon oil, Examples include vegetable flavors such as orange oil, bergamot oil, opoponax oil, vetiver oil, oris oil, and oak moss oil. Specific examples of the synthetic fragrance include hydrocarbons such as monoterpenes and sesquiterpenes, alcohols such as aliphatic alcohols, monoterpene alcohols, sesquiterpene alcohols and aromatic alcohols, aliphatic aldehydes, terpene aldehydes and aromatics. Aldehydes such as aldehydes, alicyclic ketones, terpene ketones, ketones such as macrocyclic ketones,
Esters such as terpene ester and aromatic ester,
Lactones such as undecalactone, those having a Schiff base such as auranium thiol, etc.,

For example, l-citronellol, geraniol, l-linalool, d-linalool, linalyl acetate, limonene, damascon, damacenone, β-phenylethyl alcohol, farnesol, nonyl aldehyde, rose oxide, benzyl alcohol, benzyl acetate, benzyl benzoate, Jasmon, cis-jasmone, jasmine lactone, indole, phytol, d-nerolidol, terpineol, pinene, nerol, camphene, cineol, geraniol ester, d-borneol, lavandulol, linalool ester, sesquiterpenes, methylbenzoate, methyl salicylate , Methyl anthranilate, nerolidol, sclareol, eugenol, acetyleugenol, β-cariof Ethylene, methyl-n-amyl ketone, methyl heptyl ketone, 1-menthol, menthone, isomentone, 1,8-cineole, menthyl acetate, mentofuran, geranyl formate, geranyl tiglate, citronellyl formate, patchouli alcohol, patchy Rion, Patchurenone, α-
Guaien, β-prunesene, α- or β-santalol, santen, santenone, santenol, teresantalol, santalone, α- or β-santalen,
Cinnamic aldehyde, l-ferrandrene, pinene, α, β-pinene,

N-decylaldehyde, sabinene, β-binene, elemol, methylheptenone, α-bergamotene, β-bisaborene, n-nonyl alcohol, nootkatone, p-cymene, decanal, α, δ-cadinene,
Ximol, beticerineol, α, β-vetibon, vetiverol, vetiben, α, β, γ-iron, ebernic acid, α, β-thujone, atranoline, chloroatranolin, camphor, naphthalene, 3-methylcyclopentadecanone, Muscopyridine, civetone, skatole, castrin, castramine, isocastramine, vactanol, bramannol, ambraine, terpineol, lireal, lilial, methylionone,
Examples include isoesper, acetyl cedrene, methyl dihydrojasmonate, methyl jasmonate, cyclopentadecanolide, ethylene brassylate, galactsolid, ambroxane, and the like. Examples of these flavors include those produced by biotechnology such as ethylene brushlate, 3-methylcyclopentadecanone, cyclopentadecanone, cyclopentadecanolide, and civetone. These can be used without any limitation as long as they are in accordance with the purpose and intent of the present invention. As the fragrance, the above-mentioned ones can be used alone, or any one of them can be selected and used in combination. Fragrances make the cream of the invention acceptable to the user,
It can be used in an amount sufficient to make it comfortable to use. Usually about 0.0001 to about 10% by weight of the composition can be added.

Examples of the water phase component used in the present invention include purified water such as distilled water or ion-exchanged water, or a mixture of purified water and a moisturizer or alkali. The aqueous phase component may further contain one selected from the group consisting of a surfactant, a fragrance, a preservative, a coloring agent, a moisturizing agent, and a drug. Further, among the water phase components, in particular, a mucus substance, a water-miscible organic solvent, a water-soluble component such as a water-soluble fragrance, a water-soluble colorant, a buffering agent, a drug and the like can be added. These can be used without any limitation as long as they are in accordance with the purpose and intent of the present invention.

As a moisturizer, a natural moisturizing factor (NMF =
Hydrophilic hygroscopic substances or their derivatives known as (Natural Moisture Factor),
For example, glycolipids, phospholipids, amino acids, etc. are known. Among them, particularly important components are amino acids, pyrrolidonecarboxylic acid (PCA), lactate, urea, ammonia, glucosamine, creatine, citric acid. These include salts, organic acids, peptides, sodium, potassium, calcium, magnesium, etc. Also, as moisturizing agents, glycerin, propylene glycol, sorbit, polyethylene glycol (PEG) 200, PE
Polyethylene glycol such as G600, PEG1000, PEG1500, dipropylene glycol, 1,3
-Butylene glycol, diglycerin, mannitol,
Maltitol, POE methyl glycoside, hyaluronic acid, hyaluronic acid such as sodium hyaluronate, chondroitin sulfate, collagen, elastin, sodium pyrrolidonecarboxylate, amino acids, sugars, placenta extract, aloe extract, carrot extract, seaweed extract, milk extract, Particular mention is made of pearl solubilized products.

As the moisturizing agent, the above-mentioned ones can be used alone, or any one of them can be selected and used in combination. Moisturizer,
The cream of the present invention can be blended in an amount sufficient to impart the functions of moisturizing and softening the skin, and thus the cream can be used in an amount that gives the user an excellent feeling of use. Usually about 0.0001 to about 30% by weight of the composition can be added. As the mucous substance, polysaccharides obtained from plants or microorganisms, proteins obtained from animals, semi-synthetic cellulose polymers, semi-synthetic starch polymers, semi-synthetic alginic acid polymers, polyvinyl polymers,
Examples thereof include alkylene oxide polymers.

Typical examples of mucus substances are guar gum, locust bin gum, carrageenan, galactan, gum arabic, tragacanth gum, pectin, mannan, starch, methyl cellulose, carboxymethyl cellulose, methyl hydroxypropyl cellulose, hydroxyethyl cellulose, ethyl cellulose, hydroxypropyl. Cellulose and other cellulose derivatives, carboxymethyl starch, methyl starch and other starch derivatives, alginic acid propylene glycol ester and other alginic acid derivatives, xanthan gum, dextran, succinoglucan, curdlan, gelatin, quince seed, sodium alginate, soagina, casein, albumin , Collagen, carboxyvinyl polymer, sodium polyacrylate Polyvinyl alcohol, polyvinyl pyrrolidone, polyvinyl methyl ether, polyethylene oxide. Examples of the water-miscible organic solvent include ethanol, isopropyl alcohol, ethylene glycol, tetrahydrofuran, ethylene glycol monoethyl ether and the like.

As the colorant, organic synthetic dyes, natural dyes,
Examples include inorganic pigments. Organic synthetic pigments include azo dyes such as Yellow No. 5 (Sunset Yellow FCF), Red No. 505, Red No. 230 (Eosin YS), Red No. 1
No. 04 (phloxine B), red 218 (tetrachlorotetrabromofluorescein), red 223, orange 201, red 213 (rhodamine B) and other xanthene dyes, yellow 204 (Kirin Yellow SS), yellow Quinoline dyes such as No. 203 (Kirin Yellow WS),
Triphenylmethane dyes such as blue No. 1, green 201
No. (Alizanin Cyanine Green), Green No. 202 (Quinizarin Green SS), Anthraquinone dye such as Purple No. 201, Indigo dye such as Blue No. 2, Yellow 40
Examples thereof include nitro dyes such as No. 3, pyrene dyes such as Green No. 204, and nitroso dyes such as Green No. 401.

Natural pigments include carrot, orange,
Paprika, tomato, safflower, gardenia, perilla, turnip,
Pigments obtained from plants such as grapes, safflower, buckwheat, black oak skin, cocoa beans, western red radish, purple root, beet, mushrooms, yeasts, lacquer worms, cactus worms,
Carrotenoid pigments such as oak tree worms, kermes worms, sea urchins and the like, β-carotene, β-apo-8-carotinal, capsanthin, lyropine, bixin, crocin, canthaxanthin, shisonin, rafanin Flavonoid pigments such as ninocyanin, carsamine, safrole yellow, rutin, and quercetin, flavin pigments such as lipoflavin, laccaic acid, carminic acid, kermesic acid, alizarin, shikonin, alkone, quinone pigments such as niquinochrome,
Examples include porphyrin dyes such as chlorophyll, diketone dyes such as curcumin, and betacyanidine dyes such as betanin.

Inorganic pigments and other functional pigments include mica, talc, kaolin, calcium carbonate, magnesium carbonate, silicic acid anhydride, aluminum oxide, barium sulfate and other extender pigments, red iron oxide, chromium oxide, iron oxide yellow, ultramarine blue. , Color pigments such as navy blue, carbon black, ultra-fine particles of titanium dioxide, white pigments such as zinc oxide, titanium dioxide coated mica, fish scale foil, pearlescent pigments such as bismuth oxychloride, boron nitride, polymer resin particles, synthetic mica, Examples include photochromic pigments. Examples of the alkali include alkali metal hydroxides such as sodium hydroxide and potassium hydroxide, alkali metal carbonates such as sodium carbonate and potassium carbonate, and alkaline earth metal hydroxides such as magnesium hydroxide and calcium hydroxide. , Carbonates of alkaline earth metals such as magnesium carbonate and calcium carbonate, aliphatic amines such as triethanolamine, basic amino acids such as L-arginine, and borax. These can be used without any limitation as long as they are in accordance with the purpose and intent of the present invention. Drugs include vasodilators, antihistamines, anti-inflammatory agents, vitamins, nutritional supplements,
Examples include hormones, antiperspirants, anti-inflammatory agents, sebum suppressors, sebum secretagogues, metabolism improvers, hair root function activators, lipid peroxide suppressors, cell activators, and bactericides. These can be used without any limitation as long as they are in accordance with the purpose and intent of the present invention.

For example, typical agents include arbutin, melanin production inhibitors such as kojic acid, γ-oryzanol, bio γ-linolenic acid oil, guaiazulene, β.
-Provitamin A such as carotene, vitamin A acetate, vitamin A such as vitamin A palmitate, vitamin C, vitamin C-2-phosphate, monostearyl ascorbate, vitamin C-2 such as vitamin C-2,6-dipalmitate, Vitamin B such as thiamine nitrate
_1st class, vitamin B ₂ such as riboflavin, vitamin B
₆ , vitamin B ₆ fatty acid ester, nicotinic acid, nicotinic acid amide, nicotinic acid benzyl ester, pyridoxine, pyridoxal, pyridoxamine and other vitamin B ₆ species, cyanocobalamin and other vitamin B ₁₂ species, tocopherol acetate, tocopherol calcium succinate, etc. Vitamin E and its derivatives, Cholecalciferol, Ergocalciferol and other vitamin D
, Pantothenic acid, pantothenic acid such as pantothenic acid ethyl ether, pantothenyl alcohol, biotin,
Assembly extract, cepharanthin, capsicum tincture,
Ginkgo tincture, Cantharis tincture, aloe extract, chamomile extract,

Chlorella extract, young barley leaf extract, ginkgo biloba extract, apricot extract, ibukitoranoo, ukogi extract, yellow oak, yellow lichen, licorice extract, camphor, ginseng, shikonin, senburi extract, mulberry bark, taiso extract, Ki, tomato oil, traumatic acid, garlic extract, peppermint oil, hinokitiol, hechima extract, sucrose extract, sardine extract, quince sticky substance, safflower, waremoko, rosemarinic acid extract, mini snail extract, gall snake extract, canthalis. Enzymes such as tincture, protease, lysozyme, lipase, muramidase, tissue respiration promoting factor, female hormones such as acetylcholine, glutathione, estradiol, ethinyl estradiol, androgen, pituitary hormone, prostaglandin, di Estrogen such as tilstilbestrol, β-glycyrrhetinic acid, glycyrrhizic acid derivative such as dipotassium glycyrrhizinate, allantoins such as allantoin, azulene, ε-aminocaproic acid, hydrocortisone, prednisone, adrenal cortex hormone such as prednisolone, chlor maleate Phenylamine, diphenhydramine hydrochloride, acetylsalicylic acid, ibuprofen, oxyphenbutazone, flufenamic acid, indomethacin, sulindac, naproxen, ketoprofen, planoprofen, piroxicam, ε-aminocaproic acid, sulfur, urocanic acids such as urocanic acid, 3- ( 3,4-dihydroxyphenyl) -L-
Alanine, succinic acid, diisopropylaminodichloroacetate,

Examples thereof include thioxolone, urea, potassium bromate, minoxidil, zinc pyrithione, picton olamine, chlorhexidines and halocarbane. Also,
L-cystine and L- which are known as lipid peroxide inhibitors
Cysteine or derivatives thereof, superoxide dismutase (SOD), tannin, endu,
Rutin, pralmin, pratonin, capsaicins, yellow gon extract, etc., known as cell activating agents, epicholestanol or its phosphoric acid ester, EGF, ribonucleic acid, deoxyribonucleic acid, bovine placenta-derived skin fibroblast activator-containing liquid, Calf serum extract, bovine spleen extract, L
-Arginine, royal jelly and the like. In addition, those listed as humectants, those listed as vitamins or physiologically active substances, and other additives are also considered as drugs when utilizing a specific activity possessed by them, for example, biological activity.

Representative specific examples of the water phase component used in the present invention include purified water alone or purified water,
Those containing 1,3-butylene glycol and PEG1500, purified water, glycerin, triethanolamine,
And those containing dipropylene glycol, purified water, and those containing propylene glycol. The proportion of the oil phase component used in the present invention is selected in a wide range depending on the purpose and the properties of the final product obtained, and for example, 10 wt% to 90 wt%, more preferably 10 wt% to vanishing cream and the like. It can be 30% by weight, 30% to 50% by weight for neutral cream and 50% to 85% by weight for cold cream. More preferably, the use ratio of the oil phase component used in the present invention is, for example, squalane, stearic acid, behenyl alcohol, octyldodecyl alcohol, glyceryl trioctanoate, POE (20) as the oil phase component.
Sorbitan monostearate, sorbitan monostearate, lipophilic glyceryl monostearate, avocado oil, methyl polysiloxane,

When using the one containing concentrated glycerin and 1,3-butylene glycol, 25% by weight to 45% by weight
% By weight, more preferably 30% by weight to 40% by weight, still more preferably 33% by weight to 36% by weight. Lecithin, avocado oil, sesame oil, olive oil,
And 25% by weight to 50% by weight, more preferably 30% by weight to 45% by weight, and even more preferably 34% by weight to 38% by weight when using those containing concentrated glycerin. Those containing stearic acid, stearyl alcohol, hydrogenated lanolin, squalane, and octyldodecyl alcohol, or cetanol, stearic acid, petrolatum, squalane, and glycerol tri-2.
20% to 45% by weight, more preferably 25% by weight, when using one containing ethylhexanoate
To 40% by weight, more preferably 28% to 33.
It may be 3% by volume. In the present invention, the O / W type emulsion is selected so as to be stabilized, and required depending on components used such as fatty acids, higher alcohols, fatty acid esters, oils and fats, waxes, and surfactants. H
Give the LB value. In the present invention, the use ratio of the oil phase component and the water phase component can be arbitrarily selected within a range in which the O / W type emulsion can be stabilized, and the ratio of the use components such as fatty acids, higher alcohols and fatty acids can be selected. Depending on the ester, fats and oils, waxes, surfactants, etc., the oil phase component may range from about 30 to 40% by weight, and the water phase component may range from about 60 to 70% by weight. preferable.

The compounding ratio of the typical drug used in the present invention is selected in a wide range according to the purpose and the properties of the final product obtained. For example, in the case of natural vitamin E etc. %, Preferably 0.0
10% to 0.50% by weight, more preferably 0.15%
The amount is from 0.3% to 0.30% by weight, but it is possible to add more than this. Further, in the case of bio γ-linolenic acid oil or the like, it is 0.05% by weight to 3.00% by weight, preferably 0.1% by weight.
It is 0% to 1.50% by weight, more preferably 0.50% to 1.00% by weight, but more than this can be added. Furthermore, guaiazulene or β-
In the case of carotene, etc., 0.00001% by weight to 1.00% by weight, preferably 0.0001% by weight to 0.2% by weight,
More preferably, it is 0.0004% by weight to 0.05% by weight, but more than this can be added. In the present invention, the product cream further contains a UV control agent,
A UV absorber or the like may be added, and examples thereof include a cinnamic acid-based UV absorber, a benzoic acid-based UV absorber, and a dibenzoylmethane-based UV absorber. In the present invention, the product cream may further contain a chelating agent such as EDTA and a buffering agent such as sodium citrate, lactic acid and sodium lactate. Also, a preservative such as paraben may be added, but the addition may be omitted when the product cream is refrigerated or frozen. The cream product of the present invention that has been refrigerated or stored in a frozen state may sometimes have an excellent feeling of use.

[0037]

EXAMPLES The present invention will now be described in more detail by way of examples, which are merely for better understanding of the present invention and are not intended to limit the present invention. According to the idea, various modes can be easily derived by those skilled in the art. Example 1: Ingredients Amount (a) Oil phase component (wt / wt) (1) Behenyl alcohol 2.00 (2) Lipophilic glyceryl monostearate 2.00 (3) Stearic acid 2.00 (4) Squalane 6.00 (5) Glyceryl trioctanoate 8.00 (6) Adsorption-purified lanolin 2.00 (7) Shea butter 1.00 (8) Avocado oil 2.00 (9) Methylpolysiloxane 0.40 (10) 1 , 3-butylene glycol 4.00 (11) Concentrated glycerin 8.00 (b) Water phase component (12) Purified water 61.39 (13) Potassium hydroxide 0.20 (c) Other components (14) Natural vitamins E 0.20 (15) Bio γ-linolenic acid oil 0.80 (16) β-carotene 0.01 Total 100.00

Oil phase components (1) to (11) are combined together,
"Mizuho vacuum emulsifier PVQ-5" is used, the battle mixer is about 50 rpm, and the homomixer is about 10
While stirring at 00 rpm, the mixture was gradually heated under a pressure of about 20 to 30 mmHg, and the solubility of the mixture was observed. About 30
C. to about 50.degree. C. in about 30 minutes, then to about 52.degree. C. in about 3 minutes, and then to about 54.degree. C. in about 3 minutes. About 50 ℃
It was observed that an insoluble matter was observed in a part of the mixture, a slight amount of insoluble matter was observed at about 52 ° C., and an almost transparent solution was observed at about 54 ° C. The oil phase component melt obtained at about 54 ° C. has been subjected to a dissolution treatment and previously about 5
While gradually adding the water phase components (12) and (13) kept at 4 ° C, under a pressure of about 20 to 30 mmHg, the battle mixer is about 30 rpm, and the homomixer is about 2500 r.
The mixture was emulsified by stirring at about 54 ° C. in pm. The phase inversion occurred at about 60% of the water phase part.

Thereafter, the mixture was stirred under this reduced pressure up to about 30 ° C. and cooled. In the emulsion thus obtained, component (14) natural vitamin E, (15) bio γ-linolenic acid oil and (1
6) The liquid in which β-carotene was added and mixed at room temperature in advance was brought to about 40 ° C., mixed at about 40 ° C., cooled with gentle stirring, cooled to about 30 ° C., and the target cream was obtained. Obtained. The emulsified state of the product was excellent. The stability was good even after storage for 1 week under refrigeration. A cream with a fine and even texture was obtained. The cream thus obtained was subjected to a sensory test by 5 panelists. The above cream was applied to the skin of 5 women aged 20 to 30 years twice a day in the morning and in the evening. As a result, the feeling of use was good in all cases, the cream was not irritated by any panelists, and the skin did not become red or itchy at all.

Example 2 The dissolution treatment of the first mixture of the oil phase components (1) to (11) of Example 1 and the emulsification treatment with the addition of the water phase component were carried out under a pressure of about 100 mmHg, and water was added. The same ingredients were used and treated as in Example 1 except that the phase ingredients were mixed at about 55 ° C. Oil phase component (1) ~
Regarding the mixture of (11), insoluble matter was observed in a part of the mixture at about 50 ° C, and slight insoluble matter was observed at about 52 ° C.
At 53 ° C only a slight insoluble matter was observed,
At 0 ° C, it was observed that the solution was almost transparent. The phase inversion occurred at about 60% of the water phase part. The emulsified state of the product was excellent. The stability was good even after storage for 1 week under refrigeration. A cream with a fine and even texture was obtained.

Example 3: First oil phase components (1) to (1
The same components as in Example 1 were used except that the dissolution treatment of the mixture of 1) and the emulsification treatment by adding the water phase component were performed under a pressure of about 200 mmHg, and the water phase component was mixed at about 56 ° C. It processed similarly. In the case of the mixture of the oil phase components (1) to (11), an insoluble matter was observed in a part of the mixture at about 50 ° C.
A slight amount of insoluble matter was observed at about 52 ° C., a slight amount of insoluble matter was observed at about 54 ° C., and an almost transparent solution was observed at about 56 ° C. Phase inversion is about 6 in the water phase
It happened at 0%. The emulsified state of the product was excellent.
The stability was good even after storage for 1 week under refrigeration. A cream with a fine and even texture was obtained.

Comparative Example 1: The first mixture of the oil phase components (1) to (11) of Example 1 was dissolved under atmospheric pressure,
The emulsification treatment with the addition of the aqueous phase component was performed under a pressure of about 460 mmHg, and the same components as in Example 1 were used and treated in the same manner as in Example 1 except that the aqueous phase component was mixed at about 57 ° C. In the mixture of the oil phase components (1) to (11), a part of the mixture is insoluble at about 50 ° C, a part of the mixture is not dissolved at about 52 ° C, and a slight amount of insoluble is observed at about 55 ° C. Is about 57 ℃
Finally, it was observed that the solution was almost transparent.
The phase inversion occurred at about 60% of the water phase part.

Example 4: Ingredient amount (A) Oil phase component (wt / wt)     (1) Behenyl alcohol 4.00     (2) Stearic acid 2.00     (3) Octyldodecyl alcohol 2.00     (4) Glyceryl trioctanoate 4.00     (5) POE (20) Sorbitan Mono 1.00           Stearate     (6) Sorbitan monostearate 1.00     (7) Lipophilic glyceryl monostearate 2.00     (8) Squalane 8.00     (9) Avocado oil 2.00   (10) Methyl polysiloxane 0.40   (11) Concentrated glycerin 4.00   (12) 1,3-butylene glycol 4.00 (B) Water phase component   (13) Purified water 64.59 (C) Other ingredients   (14) Natural Vitamin E 0.20   (15) Bio γ-linolenic acid oil 0.80   (16) Guaiazulen 0.01                                             Total 100.00

The oil phase components (1) to (12) are combined together,
"Mizuho vacuum emulsifier PVQ-5" is used, the battle mixer is about 50 rpm, and the homomixer is about 10
While stirring at 00 rpm, the mixture was gradually heated under a pressure of about 20 to 30 mmHg, and the solubility of the mixture was observed. About 51
An insoluble matter was observed in a part of the mixture at 0 ° C, a slight amount of insoluble matter was observed at about 55 ° C, and a substantially transparent solution was observed at about 56 ° C. About 20 to 30 while gradually adding the aqueous phase component (13) which has been subjected to the dissolution treatment and previously adjusted to about 56 ° C. to the melt obtained at about 56 ° C.
Under a pressure of mmHg, the battle mixer was stirred at about 30 rpm, and the homomixer was stirred at about 2500 rpm at about 56 ° C. to emulsify and mix. The phase inversion occurred at about 35% of the water phase part.

Thereafter, the mixture was stirred under this reduced pressure up to about 30 ° C. and cooled. Component (14) natural vitamin E, (15) bio γ-linolenic acid oil, and (16) guaiazulene were mixed at room temperature in advance, and the resulting liquid was adjusted to about 40 ° C., and the emulsion thus obtained was added to about 40 The mixture was mixed at 0 ° C, cooled with gentle stirring, and cooled to about 30 ° C to obtain the desired cream. The emulsified state of the product was excellent. The stability was good even after storage for 1 week under refrigeration. A cream with a fine and even texture was obtained. The cream thus obtained was subjected to a sensory test by 5 panelists. The above cream was applied to the skin of 5 women aged 20 to 30 years twice a day in the morning and in the evening. As a result, the feeling of use was good in all cases, the cream was not irritated by any panelists, and the skin did not become red or itchy at all.

Example 5: The dissolution treatment of the first mixture of the oil phase components (1) to (12) of Example 4 and the emulsification treatment with the addition of the water phase component were carried out under a pressure of about 100 mmHg, and water was added. The same ingredients were used and treated as in Example 4, except that the phase ingredients were mixed at about 58 ° C. Oil phase component (1) ~
In the mixture of (12), an insoluble matter was observed in a part of the mixture at about 54 ° C, a slight amount of insoluble matter was observed at about 57 ° C, and at about 58 ° C, it was almost transparently dissolved. Was observed. The phase inversion occurred at about 35% of the water phase part.
The emulsified state of the product was excellent. The stability was good even after storage for 1 week under refrigeration. A cream with a fine and even texture was obtained.

Comparative Example 2: First oil phase components (1) to (1)
Same as Example 4 except that the dissolution treatment of the mixture of 2) was performed under normal pressure, the emulsification treatment with the addition of the aqueous phase component was performed under a pressure of about 460 mmHg, and the aqueous phase component was mixed at about 59 ° C. Was used and treated similarly. Oil phase component (1) ~
In the mixture of (12), a part of the mixture is insoluble at about 55 ° C, and a part of the mixture is not dissolved at about 58 ° C.
Finally, it was observed that the solution was almost transparent.
The phase inversion occurred at about 35% of the water phase part.

Example 6: Ingredient amount (A) Oil phase component (wt / wt)     (1) Behenyl alcohol 2.0000     (2) Lipophilic type glyceryl monostearate 2.0000     (3) Stearic acid 2.0000     (4) Squalane 6.0000     (5) Glyceryl tri-2-ethylhexanoate 8.0000     (6) Adsorption purification lanolin 2.0000     (7) Olive oil 2.0000     (8) Shea butter 1.0000     (9) γ-linolenic acid oil (bio) 0.8000   (10) Natural Vitamin E 0.2000   (11) Concentrated glycerin 8.0000   (12) 1,3-butylene glycol 4.0000 (B) Water phase component   (13) Potassium hydroxide 0.2000   (14) Purified water 60.2996 (C) Other ingredients   (15) β-carotene (30%) 0.0004   (16) Hinokitiol 0.0250   (17) Brucine modified 95 degree ethyl alcohol 1.4750                                             Total 100.0000

The oil phase components (1) to (12) are combined together,
"Mizuho vacuum emulsifier PVQ-5" (capacity 5 liters) is used, the battle mixer is about 50 rpm, and the homomixer is about 1000 rpm with stirring at about 0 to 0 rpm.
The mixture was gradually heated under a pressure of 10 mmHg, and the solubility of the mixture was observed. The temperature was raised from about 50 ° C. to about 55 ° C. over about 10 minutes and then held at about 55 ° C. for about 15 minutes. At about 50 ° C., insoluble matter was observed in a part of the mixture, but at about 55 ° C., it was observed that it was transparently dissolved. Under a reduced pressure while gradually adding the aqueous phase components (13) and (14), which have been subjected to the dissolution treatment and previously set to about 55 ° C., to the melt obtained at about 55 ° C., the battle mixer is about 30 r.
pm, and the homomixer is about 55 rpm at about 2500 rpm
The mixture was emulsified by stirring at ℃. Thereafter, the mixture was stirred under this reduced pressure up to about 30 ° C. and cooled. Ingredient (15) β-carotene (3
0%), (16) hinokitiol and (17) brucine modified 95% ethyl alcohol were mixed at room temperature in advance to a temperature of about 40 ° C., which was then mixed with the emulsion thus obtained at about 40 ° C. Then, the mixture was cooled with gentle stirring and cooled to about 30 ° C. to obtain the target cream. The emulsified state of the product was excellent. The stability was good even after storage for 1 week under refrigeration. A cream with a fine and even texture was obtained.

Example 7: The dissolution treatment of the mixture of the first oil phase components (1) to (12) of Example 6 and the emulsification treatment with the addition of the aqueous phase component were carried out under a pressure of about 50 mmHg.
The same ingredients were used and treated as in Example 6 except that the aqueous phase ingredients were mixed at about 57 ° C. Oil phase components (1) to (1
In the mixture of 2), insoluble matter was observed in a part of the mixture at about 50 ° C, only a slight amount of insoluble matter was observed at about 55 ° C, and at about 57 ° C, it was observed that the mixture was almost transparent. Was done. The phase inversion occurred at about 40% of the water phase part. The emulsified state of the product was excellent. The stability was good even after storage for 1 week under refrigeration. A cream with a fine and even texture was obtained. When the viscosity was measured, it was 1850
0 cps (Tokyo Keiki B-type viscometer: 30 ° C., 12 rpm.
2 min. Rotor No. 4), pH (20 ° C.) 7.
At 73, the POV peracid value was 0.37.

Example 8: First oil phase components (1) to (1
The same components as in Example 6 were used except that the dissolution treatment of the mixture of 2) and the emulsification treatment by adding the water phase component were performed under a pressure of about 100 mmHg, and the water phase component was mixed at about 59 ° C. It processed similarly. In the case of the mixture of the oil phase components (1) to (12), an insoluble matter was observed in a part of the mixture at about 50 ° C,
A slight amount of insoluble matter was observed at about 55 ° C., only a slight amount of insoluble matter was observed at about 57 ° C., and almost transparent dissolution was observed at about 59 ° C. The phase inversion occurred at about 40% of the water phase part. The emulsified state of the product was excellent. The stability was good even after storage for 1 week under refrigeration. A cream with a fine and even texture was obtained.
When the viscosity was measured, it was 17,200 cps (Tokyo Keiki B-type viscometer: 30 ° C., 12 rpm.2 min. Rotor No. 4) and pH (20 ° C.) was 7.82.

Example 9: First oil phase components (1) to (1
Using the same components as in Example 6 except that the dissolution treatment of the mixture of 2) and the emulsification treatment with the addition of the aqueous phase component were performed under a pressure of about 200 mmHg, and the aqueous phase component was mixed at about 65 ° C. It processed similarly. In the case of the mixture of the oil phase components (1) to (12), an insoluble matter was observed in a part of the mixture at about 50 ° C,
At about 65 ° C., almost transparent dissolution was observed. The emulsified state of the product was excellent. The stability was good even after storage for 1 week under refrigeration. A cream with a fine and even texture was obtained.

Example 10: First oil phase components (1) to (1)
Using the same components as in Example 6 except that the dissolution treatment of the mixture of 2) and the emulsification treatment with the addition of the aqueous phase component were performed under a pressure of about 300 mmHg, and the aqueous phase component was mixed at about 66 ° C. It processed similarly. In the case of the mixture of the oil phase components (1) to (12), an insoluble matter was observed in a part of the mixture at about 50 ° C,
A slight amount of insoluble matter was observed at about 55 ° C., only a slight amount of insoluble matter was observed at about 62 ° C., and almost transparent dissolution was observed at about 66 ° C. The phase inversion occurred at about 40% of the water phase part. The emulsified state of the product was excellent. The stability was good even after storage for 1 week under refrigeration. A cream with a fine and even texture was obtained.
When the viscosity was measured, it was 15,050 cps (Tokyo Keiki B-type viscometer: 30 ° C., 12 rpm.2 min. Rotor No. 4), and pH (20 ° C.) was 7.84.

Comparative Example 3: First oil phase components (1) to (1)
The dissolution treatment of the mixture of 2) was performed under normal pressure. Stir about 4
It was carried out at 00 rpm. In the mixture of the oil phase components (1) to (12), an insoluble matter was observed in a part of the mixture at about 55 ° C,
It is a viscous liquid that melts somewhat transparently at about 65 ° C.
It was observed to be a transparent liquid at about 72 ° C. , Emulsification treatment by adding water phase component, about 460mm
The same ingredients were used and treated as in Example 1 except that the procedure was carried out under a pressure of Hg and the aqueous phase ingredients were mixed at about 59 ° C.
In the mixture of the oil phase components (1) to (12), a part of the mixture was insoluble at about 55 ° C, and a part of the mixture was not dissolved at about 58 ° C. Was observed. The phase inversion occurred at about 35% of the water phase part.

As is clear from the above Examples and Comparative Examples, it was unexpectedly revealed that by dissolving the oil phase component under reduced pressure, the dissolving treatment can be performed at a lower temperature. Generally, the melting temperature of the oil phase component varies depending on the source, whether it is natural or synthetic, and depending on the composition of the mixed components, but it is usually at least 70 ° C or higher, and generally 80 ° C or higher because it completely dissolves. Although it has been heated and dissolved up to the above, it has been found that by heating under reduced pressure, it can be dissolved at a substantially lower temperature so that it can be used in the production of cosmetic creams. This is completely unexpected from the physicochemical theoretical prediction that unlike the boiling point, it is unlikely to lower the melting point even if the pressure is reduced, except for special things such as sublimation. The melting point of the mixture shows a behavior that it starts to melt at a lower temperature than a pure substance in a wider range and completely melts, but in view of the relationship between the melting point and the pressure,
Even if the pressure is reduced to 0 mmHg, the melting point should not drop more than 1 ° C. It is not known that the reduced pressure allows the oil phase component mixture, which is the raw material of the cosmetic cream, to dissolve at such lower temperature. This is not based on theoretical or detailed observation of phenomena, but the solids of the oil phase component mixture, which is the raw material of cosmetic cream, contains a large amount of air, etc. It is considered that, after coming out, it acts as a heat insulating layer on the surface of the solid and inhibits the transfer of heat, and as a result, the melting could not be achieved by the normal melting treatment unless the temperature was raised to a high temperature. However, it is considered that air or the like that forms a heat insulating layer can be efficiently removed from the solid surface or the like in a depressurized state, and the heat transfer property is not hindered. Therefore, the present invention, by any method based on such an idea,
It is also an embodiment including a method of achieving a dissolution treatment of an oil phase component mixture which is a substantially milder raw material for a cosmetic cream. Some oil phase component mixtures for cosmetics may be oxidized or decomposed when heated for a long period of time or at a high temperature, and some components of a complex composition are oxidized or decomposed. Can be effectively prevented.

Example 11: Ingredient amount (A) Oil phase component (wt / wt)     (1) Behenyl alcohol 4.00     (2) Self-emulsifying glyceryl monostearate 4.00     (3) Octyldodecyl alcohol 2.00     (4) Squalane 4.00     (5) Lecithin 2.00     (6) Avocado oil 2.00     (7) Sesame oil 0.80     (8) Olive oil 2.00     (9) Concentrated glycerin 16.00 (B) Water phase component   (10) Purified water 62.19 (C) Other ingredients   (11) Natural vitamin E 0.20   (12) Bio γ-linolenic acid oil 0.80   (13) β-carotene 0.01                                             Total 100.00

The oil phase components (1) to (9) were put together, and mixed and dissolved under stirring under the same conditions as in Example 1 and Examples 6 to 10 with a homomixer, and the resulting melt was
Emulsification and mixing are performed while gradually adding (10) purified water, which is a preheated aqueous phase component. Ingredient (11) Natural Vitamin E, (12) Bio γ-linolenic acid oil and (13) β
-Carotene premixed at room temperature to a temperature of about 40 ° C, mixed with the emulsion thus obtained, cooled with gentle stirring, and further cooled to about 30 ° C,
The desired cream was obtained. The emulsified state of the product was excellent. The stability was good even after storage for 1 week under refrigeration. The cream thus obtained was subjected to a sensory test by 5 panelists. The above cream is applied to the skin of 5 women aged 20 to 30 times twice a day in the morning and in the evening. As a result, the feeling of use was good in all cases, the cream was not irritated by any panelists, and itching did not occur when the skin became red.

Example 12: Ingredient amount (A) Oil phase component (wt / wt)     (1) Stearyl alcohol 4.00     (2) Stearic acid 2.00     (3) Hydrogenated lanolin 4.00     (4) Squalane 9.00     (5) Octyldodecyl alcohol 10.00     (6) POE (20) cetyl alcohol ether 3.00     (7) Glycerin monostearate 2.00 (B) Water phase component     (9) Purified water 56.00   (10) 1,3-butylene glycol 4.00   (11) PEG 1500 4.00   (12) Natural moisturizer 0.99 (C) Other ingredients   (13) Natural Vitamin E 0.20   (14) Bio γ-linolenic acid oil 0.80   (15) β-carotene 0.01                                             Total 100.00

The oil phase components (1) to (7) were put together, and mixed and dissolved under stirring in a homomixer under the same conditions as in Example 1 and Examples 6 to 10 to obtain a dissolved product. The mixture of (9) to (12), which is the preheated aqueous phase component, was gradually added and stirred to be emulsified and mixed. Component (13) natural vitamin E, (14) bio γ-linolenic acid oil and (15) β-carotene were mixed in advance at room temperature to a liquid of about 40 ° C., which was added to the emulsion thus obtained, The mixture was mixed at about 40 ° C., cooled with gentle stirring, and further cooled to about 30 ° C. to obtain the desired cream. The emulsified state of the product was excellent. Also under refrigeration 1
The stability was good even after storage for a week. The cream thus obtained is subjected to a sensory test by 5 panelists. The above cream is applied to the skin of 5 women aged 20 to 30 times twice a day in the morning and in the evening. As a result, the feeling of use was good in all cases, the cream was not irritating to any panelists, and the itching of the skin did not occur. In addition,
In addition to the above-mentioned compositional components, those in which a preservative and a flavor were added were also excellent in the emulsified state of the product.

Example 13: Ingredient amount (A) Oil phase component (wt / wt)     (1) Stearyl alcohol 4.00     (2) Stearic acid 8.00     (3) Butyl stearate 6.00     (4) Glycerin monostearate 2.00 (B) Water phase component     (5) Purified water 72.09     (6) Propylene glycol 5.00     (7) Potassium hydroxide 0.40     (8) Natural moisturizer 1.00 (C) Fragrance 0.50 (D) Other ingredients     (9) Natural vitamin E 0.20   (10) Bio γ-linolenic acid oil 0.80   (11) β-carotene 0.01                                             Total 100.00

The oil phase components (1) to (4) were combined, mixed and dissolved under stirring under the same conditions as in Example 1 and Examples 6 to 10, and the resulting melt was flavored under the same conditions. Into the mixture thus obtained, the aqueous phase mixture prepared in advance by heating is gradually added and stirred to emulsify and mix. Ingredient (9) Natural Vitamin E, (10) Bio γ-
A liquid prepared by mixing linolenic acid oil and (11) β-carotene at room temperature in advance is brought to about 40 ° C., and the emulsion thus obtained is mixed at about 40 ° C., cooled, and further treated. It cooled to 30 degreeC and obtained the target cream. The emulsified state of the product was excellent. The stability was good even after storage for 1 week under refrigeration.

Example 14: Ingredient amount (A) Oil phase component (wt / wt)     (1) Cetyl alcohol 5.00     (2) Stearic acid 3.00     (3) Vaseline 5.00     (4) Squalane 10.00     (5) Glycerol tri-2-ethylhexanoate 7.00     (6) Propylene glycol monostearate 3.00     (7) POE (20) cetyl alcohol ether 3.00 (B) Water phase component     (8) Purified water 49.49     (9) Dipropylene glycol 5.00   (10) Triethanolamine 1.00   (11) Glycerin 2.00   (12) Bifidobacteria milk fermentation product 5.00 (C) Fragrance 0.50 (D) Other ingredients   (13) Natural Vitamin E 0.20   (14) Bio γ-linolenic acid oil 0.80   (15) β-carotene 0.01                                             Total 100.00

The oil phase components (1) to (7) were combined, mixed and dissolved under stirring under the same conditions as in Example 1 and Examples 6 to 10, and the resulting melt was flavored under the same conditions. Was added to the mixture thus obtained, and the aqueous phase mixture prepared in advance by heating was gradually added to the mixture to be emulsified and mixed. Ingredients (13) Natural Vitamin E, (14) Bio γ
A solution of linolenic acid oil and (15) β-carotene pre-mixed at room temperature to about 40 ° C., which was mixed with the emulsion thus obtained at about 40 ° C., followed by cooling treatment, and It cooled to about 30 degreeC and obtained the target cream. The emulsified state of the product was excellent and the cream had a refreshing feel. The stability was good even after storage for 1 week under refrigeration.

Example 15: Ingredient amount (A) Oil phase component (wt / wt)     (1) Solid paraffin 5.00     (2) Beeswax 10.00     (3) Vaseline 15.00     (4) Liquid paraffin 31.00     (5) Glycerin monostearate 2.00     (6) POE (20) Sorbitan           Monolauric acid ester 2.00 (B) Water phase component     (7) Purified water 28.29     (8) 1,3-butylene glycol 2.00     (9) Borax 0.20   (10) Bifidobacteria Milk Fermentation Product 3.00 (C) Fragrance 0.50 (D) Other ingredients   (11) Natural vitamin E 0.20   (12) Bio γ-linolenic acid oil 0.80   (13) β-carotene 0.01                                             Total 100.00

The oil phase components (1) to (6) were combined and mixed and dissolved under stirring under the same conditions as in Example 1 and Examples 6 to 10, and the resulting melt was subjected to a fragrance under the same conditions. In addition,
An aqueous phase mixture prepared by heating in advance was gradually added to the mixture thus obtained, and the mixture was emulsified and mixed by stirring. Component (11) natural vitamin E, (12) bio γ-linolenic acid oil, and (13) β-carotene were mixed in advance at room temperature to obtain a liquid, which was heated to about 40 ° C. , Mix at about 40 ° C, cool, and add about 30
It cooled to ℃ and obtained the target cream. The emulsified state of the product was excellent and the cream had a refreshing feel. The stability was good even after storage for 1 week under refrigeration.

Example 16: Ingredient amount (A) Oil phase component (wt / wt)     (1) Microcrystalline wax 9.00     (2) Solid paraffin 2.00     (3) Beeswax 3.00     (4) Vaseline 5.00     (5) Reduced lanolin 5.00     (6) Squalane 29.00     (7) Hexadecyl adipate 10.00     (8) Glycerin monooleate 3.50     (9) POE (20) Sorbitan           Monooleate 1.00 (B) Water phase component   (10) Purified water 25.99   (12) Propylene glycol 3.00   (13) Bifidobacteria Milk Fermentation Product 2.00 (C) Fragrance 0.50 (D) Other ingredients   (14) Natural Vitamin E 0.20   (15) Bio γ-linolenic acid oil 0.80   (16) β-carotene 0.01                                             Total 100.00

The oil phase components (1) to (9) were combined, mixed and dissolved under stirring under the same conditions as in Example 1 and Examples 6 to 10, and the resulting melt was subjected to a fragrance under the same conditions. Was added to the mixture thus obtained, and the aqueous phase mixture prepared in advance by heating was gradually added while stirring to emulsify. Ingredients (14) Natural Vitamin E, (15) Bio γ
A solution of linolenic acid oil and (16) β-carotene mixed at room temperature in advance at about 40 ° C., and the emulsion thus obtained is mixed at about 40 ° C. and cooled, and further It cooled to about 30 degreeC and obtained the target cream. The emulsified state of the product was excellent and the cream had a refreshing feel. The stability was good even after storage for 1 week under refrigeration.

Example 17: Ingredient amount (A) Oil phase component (wt / wt)     (1) Stearic acid 2.00     (2) Cetyl alcohol 3.00     (3) Vaseline 10.00     (4) Liquid paraffin 33.00     (5) Isopropyl myristate 10.00     (6) Glycerin monostearate 2.50     (7) POE (20) Sorbitan           Monostearate ester 2.50 (B) Water phase component     (8) Purified water 30.89     (9) Potassium hydroxide 0.10   (10) Propylene glycol 3.00   (11) Bifidobacteria milk fermentation product 2.00 (C) Fragrance 0.50 (D) Other ingredients   (12) Natural Vitamin E 0.20   (13) Bio γ-linolenic acid oil 0.80   (14) β-carotene 0.01                                             Total 100.00

The oil phase components (1) to (7) were put together, and mixed and dissolved under stirring under the same conditions as in Example 1 and Examples 6 to 10, and the resulting melt was flavored under the same conditions. Was added to the mixture thus obtained, and the aqueous phase mixture prepared by heating at about 60 ° C. was gradually added while stirring to emulsify and mix. Component (12) natural vitamin E, (13) bio γ-linolenic acid oil, and (14) β-carotene were mixed in advance at room temperature, and the temperature was adjusted to about 40 ° C. The mixture was mixed at about 40 ° C, cooled, and further cooled to about 30 ° C to obtain the target cream. The emulsified state of the product was excellent and the cream had a refreshing feel. The stability was good even after storage for 1 week under refrigeration.

[0070]

In the present invention, avoiding to the oil phase component of the prior art were dissolved by heating at least 70 ° C. or higher temperature, followed by emulsification at 70 ° C. or higher temperatures, normal O / For W-type skin cream production
Inert atmosphere at 40 ° C to 65 ° C, which is lower than the temperature
It is possible to perform an emulsification treatment by dissolving the oil phase component under a medium and reduced pressure and mixing the oil phase component and the water phase component at a lower temperature. As a result, useful ingredients that are unstable to heat can be arbitrarily blended, their decomposition can be prevented, the formation of irritants can be suppressed, and allergies can be caused by the long-term use of the cream. There is no problem that the skin becomes red or itchy. In addition, according to the method of the present invention, the quality of the product is good and the usability is satisfactory even though it is manufactured at a low temperature. In the present invention, since all production can be carried out at a low temperature, it is possible to omit the addition of an antioxidant and the like, and it is possible to prevent problems associated with decomposition of components. The product produced by the method of the present invention can omit addition of an antioxidant and the like, and has good quality even if it is stored at a low temperature. In some cases, the cream
Even if it is frozen and stored, there is no problem in the feeling and product, and it is also comfortable to use. Further, since vanishing cream uses an alkali for the emulsification treatment, the emulsification treatment must be carried out at a high temperature of 75 ° C. to 85 ° C., and a component unstable to heat cannot be used. However, according to the present invention, it is possible to obtain a product which can be treated at a temperature lower than that and has no problem in use.

[Brief description of drawings]

FIG. 1 shows a manufacturing process diagram of an O / W cream according to a conventional method.

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁷ Identification code FI A61K 7/48 A61K 7/48 9/107 9/107 (56) Reference JP-A-5-4912 (JP, A) JP Japanese Unexamined Patent Publication No. 2-258042 (JP, A) Japanese Unexamined Patent Publication No. 59-164397 (JP, A) Japanese Unexamined Patent Publication No. 63-221835 (JP, A) Japanese Unexamined Patent Publication No. 54-45351 (JP, A) Japanese Unexamined Patent Publication No. 58-23613 (JP , A) Actual development Sho 62-160643 (JP, U) (58) Fields investigated (Int.Cl. ⁷ , DB name) A61K ^7/ 00-7/50

Claims (34)

(57) [Claims] 1. When producing an O / W type skin cream from an oil phase component and an aqueous phase component, the oil phase component is treated in an inert atmosphere.
Made in normal O / W type skin cream under reduced pressure in the atmosphere
The mixing and dissolution treatment at a temperature lower than that in the manufacturing process of 40 ° C. to 65 ° C. , and then the oil phase component and the aqueous phase component obtained by the dissolution treatment are mixed and emulsified at low temperature. A method for producing an O / W type skin cream. 2. The mixing and dissolution treatment step of the oil phase components is performed from 0 to
The method for producing an O / W type skin cream according to claim 1, which is performed under 300 mmHg. 3. The mixing and dissolution treatment step of the oil phase components is performed from 0 to
The method for producing an O / W type skin cream according to claim 1, which is performed under a pressure of 200 mmHg. 4. The mixing and dissolution treatment step of the oil phase components is performed from 0 to
The method for producing an O / W type skin cream according to claim 1, which is carried out under 100 mmHg. 5. The mixing and dissolution treatment step of the oil phase components is performed from 0 to
The method for producing an O / W type skin cream according to claim 1, which is performed under 50 mmHg. 6. The mixing and dissolution treatment step of the oil phase components is performed from 0 to
The method for producing an O / W type skin cream according to claim 1, which is performed under 30 mmHg. 7. The mixing and dissolution treatment step of the oil phase components is performed from 0 to
The method for producing an O / W type skin cream according to claim 1, which is carried out under 10 mmHg. 8. The mixing and dissolution treatment step of the oil phase components is 45 ° C.
The method for producing an O / W type skin cream according to any one of claims 1 to 8 , wherein the method is carried out at 60 to 60 ° C. 9. The mixing and dissolution treatment step of the oil phase components is 50 ° C.
Claim 1-7 production method of an O / W type skin cream according to any one of the characterized in that which is performed at 5 9 ° C. from. 10. The process of mixing and dissolving oil phase components is 0 or not.
Method for producing O / W type skin cream according to claim 1, characterized in that which is performed at 6 0 ° C. from even DOO 50 ° C. The et 2 00mmHg. 11. emulsification processing steps, the production method of the O / W type skin cream according to any one of claims 1 to 1 0, characterized in that it is intended to be carried out under reduced pressure. 12. The emulsification treatment step is from 0 to 300 mmH.
method for producing O / W type skin cream according to any one of claims 1 to 10, characterized in that those performed under g. 13. The emulsification treatment step is from 0 to 200 mmH.
method for producing O / W type skin cream according to any one of claims 1 to 10, characterized in that those performed under g. 14. The emulsification process comprises 0 to 100 mmH.
method for producing O / W type skin cream according to any one of claims 1 to 10, characterized in that those performed under g. 15. The emulsification treatment step is 0 to 50 mmHg.
The method according to claim 1, which is performed under
10. The method for producing an O / W type skin cream according to any one of 10 to 10 . 16. The emulsification treatment step comprises 0 to 10 mmHg.
The method according to claim 1, which is performed under
10. The method for producing an O / W type skin cream according to any one of 10 to 10 . 17. emulsification processing steps, the production method of the O / W type skin cream according to any one of claims 1 to 16, characterized in that to be performed in an inert atmosphere. 18. emulsification processing steps, the production method of the O / W type skin cream according to any one of claims 1 to 17, characterized in that which is performed at 6 5 ° C. from 40 ° C.. 19. emulsification processing steps, the production method of the O / W type skin cream according to any one of claims 1 to 17, characterized in that which is performed at 5 6 ° C. from 50 ° C.. 20. The emulsification treatment step is from 0 to 200 mmH
method for producing O / W type skin cream according to any one of claims 1 to 19, characterized in that which is performed under g. 21. emulsification process, the production method of the O / W type skin cream according to any one of claims 1 to 20, characterized in that it is intended to be made by a homomixer. 22. The oil phase component, solid form oil, the O / W type skin cream according to any one of claims 1 to 21, characterized in that those containing semi-solid oil or fluid oil Production method. 23. The oil phase component, solid-type oil, a semi-solid oil,
And manufacturing method of the O / W type skin cream according to any one of claims 1 to 21, characterized in that those containing the flow oil. 24. The oil phase component further contains one selected from the group consisting of a surfactant, a perfume, a preservative, a colorant, a moisturizer, and a drug.
25. The method for producing an O / W type skin cream according to any one of claims 23 to 23 . 25. The aqueous phase component is at least the production method of an O / W type skin cream according to any one of claims 1 to 24, that wherein the purified water is to contain. 26. The aqueous phase component contains at least purified water and a humectant.
26. The method for producing an O / W type skin cream according to any one of 25 . 27. The aqueous phase component contains at least purified water and an alkali.
27. The method for producing an O / W type skin cream according to any of 26 to 26 . 28. The aqueous phase component further contains one selected from the group consisting of a surfactant, a fragrance, an antiseptic, a coloring agent, a moisturizer, and a drug.
28. The method for producing an O / W type skin cream according to any one of 27 to 27 . 29. Subsequent to the emulsification treatment , a fragrance, a preservative, a coloring agent, which is a component unstable to heat in the cooling step ,
A humectant, and an agent selected from the group consisting of medicines are added, O according to any one of claims 1 to 28.
/ Method for producing W-type skin cream. 30. In producing an O / W type skin cream from an oil phase component and an aqueous phase component , 0 to 200 mm
Oil phase component in Hg in an inert atmosphere and normal O / W
40 ° C, which is lower than in the production of type skin cream
To 65 ° C. for mixing and dissolving, and then mixing the oil phase component and the aqueous phase component obtained by the above treatment to 0 to 200 mm
The product obtained by the emulsification treatment with Hg and then the treatment in this way has a fragrance which is a heat labile component at 35 ° C to 58 ° C ,
Selected from the group consisting of preservatives, colorants, moisturizers, and agents
What is added and mixed is processed.
29. The method for producing an O / W type skin cream according to any one of 29 . 31. The oil phase component comprises at least behenyl alcohol, lipophilic glyceryl monostearate, stearic acid, squalane, glyceryl trioctanoate, adsorption-purified lanolin, shea butter, avocado oil, 1,3-butylene glycol and concentrated glycerin. Containing, or behenyl alcohol, stearic acid, octyldodecyl alcohol, glyceryl trioctanoate,
POE (20) sorbitan monostearate,
A sorbitan monostearate, a lipophilic glyceryl monostearate, squalane, avocado oil, methylpolysiloxane, concentrated glycerin, and 1,3-butylene glycol. 31. The method for producing an O / W type skin cream according to any of 30 . 32. The heat labile component is selected from the group consisting of natural vitamin E, bio γ-linolenic acid oil, β-carotene, and guaiazulene.
32. The method for producing an O / W type skin cream according to any of 29 to 31 . 33. The oil phase component is added in an inert atmosphere from 0 to 2
Also collected by mixed dissolving treatment at 6 0 ° C. from 50 ° C. to 00MmHg, subsequently thus dissolving treatment and 6 the resulting oil phase component and aqueous phase component from also DOO 50 ° C. from 0 2 00MmHg of by 0
In the course of cooling the emulsion thus obtained , the fragrance, preservative, coloring agent, humectant, and chemicals which are unstable to heat at 35 ° C. to 58 ° C.
Those selected the group or al consisting or natural vitamin E, Bio
γ-linolenic acid oil, β-carotene, and guaia zule
Claim formulating those selected from the group consisting of down 1-3
3. The method for producing an O / W type skin cream according to any one of 2 above. 34. a from the oil phase components 30 4 0 wt%, claim 1-3 aqueous phase component is 7 0 wt% to 60
4. The method for producing an O / W type skin cream according to any one of 3 above.