JP2021050170A - Louse expellent - Google Patents
Louse expellent Download PDFInfo
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- JP2021050170A JP2021050170A JP2019175042A JP2019175042A JP2021050170A JP 2021050170 A JP2021050170 A JP 2021050170A JP 2019175042 A JP2019175042 A JP 2019175042A JP 2019175042 A JP2019175042 A JP 2019175042A JP 2021050170 A JP2021050170 A JP 2021050170A
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- lice
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- -1 biguanide compound Chemical class 0.000 claims abstract description 81
- 150000001875 compounds Chemical class 0.000 claims abstract description 25
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- 239000004094 surface-active agent Substances 0.000 claims abstract description 18
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000004471 Glycine Substances 0.000 claims abstract description 7
- 239000003120 macrolide antibiotic agent Substances 0.000 claims abstract description 7
- 239000004480 active ingredient Substances 0.000 claims abstract description 5
- KAESVJOAVNADME-UHFFFAOYSA-N 1H-pyrrole Natural products C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims abstract description 4
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- 241001674048 Phthiraptera Species 0.000 claims description 40
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- SIYLLGKDQZGJHK-UHFFFAOYSA-N dimethyl-(phenylmethyl)-[2-[2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy]ethyl]ammonium Chemical compound C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 SIYLLGKDQZGJHK-UHFFFAOYSA-N 0.000 claims 1
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- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
- ONLRKTIYOMZEJM-UHFFFAOYSA-N n-methylmethanamine oxide Chemical compound C[NH+](C)[O-] ONLRKTIYOMZEJM-UHFFFAOYSA-N 0.000 description 1
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- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 description 1
- 229940075560 sodium lauryl sulfoacetate Drugs 0.000 description 1
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- 235000010265 sodium sulphite Nutrition 0.000 description 1
- SXHLENDCVBIJFO-UHFFFAOYSA-M sodium;2-[2-(2-dodecoxyethoxy)ethoxy]ethyl sulfate Chemical compound [Na+].CCCCCCCCCCCCOCCOCCOCCOS([O-])(=O)=O SXHLENDCVBIJFO-UHFFFAOYSA-M 0.000 description 1
- UAJTZZNRJCKXJN-UHFFFAOYSA-M sodium;2-dodecoxy-2-oxoethanesulfonate Chemical compound [Na+].CCCCCCCCCCCCOC(=O)CS([O-])(=O)=O UAJTZZNRJCKXJN-UHFFFAOYSA-M 0.000 description 1
- KVCGISUBCHHTDD-UHFFFAOYSA-M sodium;4-methylbenzenesulfonate Chemical compound [Na+].CC1=CC=C(S([O-])(=O)=O)C=C1 KVCGISUBCHHTDD-UHFFFAOYSA-M 0.000 description 1
- QEKATQBVVAZOAY-UHFFFAOYSA-M sodium;4-propan-2-ylbenzenesulfonate Chemical compound [Na+].CC(C)C1=CC=C(S([O-])(=O)=O)C=C1 QEKATQBVVAZOAY-UHFFFAOYSA-M 0.000 description 1
- AIMUHNZKNFEZSN-UHFFFAOYSA-M sodium;decane-1-sulfonate Chemical compound [Na+].CCCCCCCCCCS([O-])(=O)=O AIMUHNZKNFEZSN-UHFFFAOYSA-M 0.000 description 1
- FIWQZURFGYXCEO-UHFFFAOYSA-M sodium;decanoate Chemical compound [Na+].CCCCCCCCCC([O-])=O FIWQZURFGYXCEO-UHFFFAOYSA-M 0.000 description 1
- DAJSVUQLFFJUSX-UHFFFAOYSA-M sodium;dodecane-1-sulfonate Chemical compound [Na+].CCCCCCCCCCCCS([O-])(=O)=O DAJSVUQLFFJUSX-UHFFFAOYSA-M 0.000 description 1
- GGXKEBACDBNFAF-UHFFFAOYSA-M sodium;hexadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCC([O-])=O GGXKEBACDBNFAF-UHFFFAOYSA-M 0.000 description 1
- GGHPAKFFUZUEKL-UHFFFAOYSA-M sodium;hexadecyl sulfate Chemical compound [Na+].CCCCCCCCCCCCCCCCOS([O-])(=O)=O GGHPAKFFUZUEKL-UHFFFAOYSA-M 0.000 description 1
- QWSZRRAAFHGKCH-UHFFFAOYSA-M sodium;hexane-1-sulfonate Chemical compound [Na+].CCCCCCS([O-])(=O)=O QWSZRRAAFHGKCH-UHFFFAOYSA-M 0.000 description 1
- HRQDCDQDOPSGBR-UHFFFAOYSA-M sodium;octane-1-sulfonate Chemical compound [Na+].CCCCCCCCS([O-])(=O)=O HRQDCDQDOPSGBR-UHFFFAOYSA-M 0.000 description 1
- UPUIQOIQVMNQAP-UHFFFAOYSA-M sodium;tetradecyl sulfate Chemical compound [Na+].CCCCCCCCCCCCCCOS([O-])(=O)=O UPUIQOIQVMNQAP-UHFFFAOYSA-M 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
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- 239000001570 sorbitan monopalmitate Substances 0.000 description 1
- 229940031953 sorbitan monopalmitate Drugs 0.000 description 1
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- 235000011076 sorbitan monostearate Nutrition 0.000 description 1
- 229940035048 sorbitan monostearate Drugs 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 229940012831 stearyl alcohol Drugs 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- DPKBAXPHAYBPRL-UHFFFAOYSA-M tetrabutylazanium;iodide Chemical compound [I-].CCCC[N+](CCCC)(CCCC)CCCC DPKBAXPHAYBPRL-UHFFFAOYSA-M 0.000 description 1
- DDFYFBUWEBINLX-UHFFFAOYSA-M tetramethylammonium bromide Chemical compound [Br-].C[N+](C)(C)C DDFYFBUWEBINLX-UHFFFAOYSA-M 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
- RHZZVWTVJHZKAH-UHFFFAOYSA-K trisodium;naphthalene-1,2,3-trisulfonate Chemical compound [Na+].[Na+].[Na+].C1=CC=C2C(S([O-])(=O)=O)=C(S([O-])(=O)=O)C(S(=O)(=O)[O-])=CC2=C1 RHZZVWTVJHZKAH-UHFFFAOYSA-K 0.000 description 1
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- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
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- 235000020681 well water Nutrition 0.000 description 1
- 239000002349 well water Substances 0.000 description 1
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- 235000004835 α-tocopherol Nutrition 0.000 description 1
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Description
本発明は、安全性及び実用性に優れ、シラミの駆除について効果を有する衛生害虫駆除剤に関する。 The present invention relates to a sanitary pest control agent that is excellent in safety and practicality and is effective in controlling lice.
従来、シラミからの被害を防ぐために、また、被害の拡散を防ぐために、人や動物に塗布して使用する衛生害虫駆除剤が知られている。一般的に、シラミは保育園児、幼稚園児、小学校低学年の児童などに寄生することが多いため、人や動物に使用できる薬剤として、確かな安全性を有するピレスロイド系殺虫剤のフェノトリンが知られているが、近年、それら神経細胞に働きかける薬剤に対しては抵抗性を有するシラミの存在も報告されているため、ピレスロイド系の作用機序とは異なり、また、現在使用されているフェノトリン製剤と同程度以上の安全性及び有効性を有する製剤が求められている。 Conventionally, sanitary pest control agents used by applying to humans and animals have been known in order to prevent damage from lice and to prevent the spread of damage. In general, lice often parasitize nursery school children, kindergarten children, children in the lower grades of elementary school, etc., so phenothrin, a pyrethroid pesticide with certain safety, is known as a drug that can be used for humans and animals. However, in recent years, the existence of lice that are resistant to drugs that act on these nerve cells has also been reported, so it is different from the mechanism of action of pyrethroids, and it is different from the phenothrin preparations currently used. There is a demand for a preparation having the same level of safety and efficacy.
例えば、特許文献１には、ピレスロイド系などの殺虫剤を含まずに、イソノナン酸イソデシル、イソノナン酸イソトリデシル、２−エチルヘキサン酸２−ヘキシルデシルを有効成分とする組成物において、シラミ成虫に対して駆除効果があることが開示されており、これらはシラミの気門を物理的に封じて窒息させる作用を奏するものである。 For example, Patent Document 1 describes an adult lice in a composition containing isodecyl isononanoate, isotridecyl isononanoate, and 2-hexyldecyl 2-ethylhexanoate as active ingredients without containing an insecticide such as a pyrethroid. It has been disclosed that it has an extermination effect, and these have the effect of physically blocking and choking the lice's airway.
しかしながら、特許文献１に記載されている組成物における有効成分が油脂であり効果を発現させる目的で組成物中に多くの量を配合する必要があるので使用後に取り除きにくいなどの問題があるため、神経毒として作用するピレスロイド系成分や、特許文献１に記載されているようなシラミの気門を物理的に封じて窒息させる油脂成分とは異なる作用機序を有する駆除剤が求められている。 However, since the active ingredient in the composition described in Patent Document 1 is an oil and fat and it is necessary to add a large amount to the composition for the purpose of exhibiting the effect, there is a problem that it is difficult to remove after use. There is a need for a repellent having a mechanism of action different from that of a pyrethroid component that acts as a neurotoxin and an oil / fat component that physically seals and suffocates the lice's spiracles as described in Patent Document 1.
そこで、本発明では、神経毒として作用するピレスロイド系成分や、シラミの気門を物理的に封じて窒息させる製剤とは異なりながらも、人体等の外皮に対して使用されており、外皮に使用する際にも安全性に優れている成分を用いてシラミを効果的に駆除することができるシラミ駆除剤を提供することを目的とする。 Therefore, in the present invention, although it is different from the pyrethroid component that acts as a neurotoxin and the preparation that physically seals and suffocates the lice's airway, it is used for the outer skin of the human body and the like, and is used for the outer skin. It is an object of the present invention to provide a lice exterminating agent capable of effectively exterminating lice by using an ingredient having excellent safety.
〔１〕すなわち、本発明に係るシラミ駆除剤は、ビクアナイト系化合物、フェノール系化合物、四級アンモニウム塩化合物、グリシン系界面活性剤から選ばれる少なくとも１種の消毒成分又はマクロライド系化合物、アゾール系化合物から選ばれる少なくとも１種の抗菌成分を含有することを特徴とするシラミ駆除剤である。 [1] That is, the shirami repellent according to the present invention is at least one disinfectant component selected from a biquanite compound, a phenol compound, a quaternary ammonium salt compound, a glycine surfactant, a macrolide compound, and an azole compound. It is a shirami exterminating agent characterized by containing at least one antibacterial component selected from compounds.
〔２〕そして、前記消毒成分において、ビクアナイト系化合物がグルコン酸クロルヘキシジン又はオラネキシジングルコン酸塩であり、フェノール系化合物がイソプロピルメチルフェノール、トリクロサン又はクロルキシレノールであり、四級アンモニウム塩化合物がベンザルコニウム塩化物、ベンゼトニウム塩化物、塩化セチルピリジニウム又はアクリノールであり、グリシン系界面活性剤が塩酸アルキルジアミノエチルグリシン又は塩酸アルキルポリアミノエチルグリシンであり、前記抗菌成分において、アゾール系化合物がミコナゾール、ケトコナゾールであり、マクロライド系化合物がエリスロマイシン、クラリスロマイシン、イベルメクチン、エプリノメクチン、セラメクチン、ドラメクチン、ミルベマイシンオキシム、アベメクチン、モキシデクチン、アバメクチンであることを特徴とする前記〔１〕に記載のシラミ駆除剤である。 [2] In the disinfectant component, the biquanite compound is chlorhexidine gluconate or oranexidine lactate, the phenol compound is isopropylmethylphenol, triclosan or chlorxylenol, and the quaternary ammonium salt compound is benzalco. Nium chloride, benzethonium chloride, cetylpyridinium chloride or acrinol, the glycine-based surfactant is alkyldiaminoethylglycine hydrochloride or alkylpolyaminoethylglycine hydrochloride, and in the antibacterial component, the azole compounds are myconazole and ketoconazole. The shirami repellent according to the above [1], wherein the macrolide compound is erythromycin, clarisromycin, ibermectin, eprinomectin, selamectin, dramectin, milbemycin oxime, abemectin, moxidectin, or abamectin.
〔３〕そして、前記消毒成分又は前記抗菌成分が０．０２〜１０重量％含有することを特徴とする前記〔１〕又は前記〔２〕に記載のシラミ駆除剤である。 [3] The lice repellent according to the above [1] or the above [2], wherein the disinfectant component or the antibacterial component is contained in an amount of 0.02 to 10% by weight.
〔４〕そして、界面活性剤を含有することを特徴とする前記〔１〕から前記〔３〕のいずれかに記載のシラミ駆除剤である。 [4] The lice repellent according to any one of the above [1] to [3], which is characterized by containing a surfactant.
本発明のシラミ駆除剤によれば、神経毒として作用するピレスロイド系成分や、シラミの気門を物理的に封じて窒息させる油脂成分とは異なりながらも、人体等の外皮に対して使用されており、外皮に使用する際にも安全性に優れている成分を用いてシラミを効果的に駆除することができる。 According to the lice repellent of the present invention, although it is different from the pyrethroid component that acts as a neurotoxin and the oil and fat component that physically seals and suffocates the lice's airway, it is used for the outer skin of the human body and the like. It is possible to effectively remove lice by using an ingredient that is excellent in safety even when used on the outer skin.
以下、本発明のシラミ駆除剤に関する実施形態について詳しく説明する。なお、説明中における範囲を示す表記のある場合は、上限と下限を含有するものである。 Hereinafter, embodiments of the lice repellent of the present invention will be described in detail. In addition, when there is a notation indicating a range in the explanation, it includes an upper limit and a lower limit.
本発明の消毒成分としては、ビクアナイト系化合物、フェノール系化合物、四級アンモニウム塩化合物、グリシン系界面活性剤から選ばれる少なくとも１種である。または、本発明の抗菌成分としては、マクロライド系化合物、アゾール系化合物から選ばれる少なくとも１種である。これらの消毒成分又は抗菌成分により、シラミに対する直接的な駆除効果よりもシラミの体内に共生するリーシア等の細菌を死滅させることでそれら細菌から供給される栄養要素が断たれて死滅するという間接的な駆除効果を奏する。 The disinfectant component of the present invention is at least one selected from biquanite compounds, phenol compounds, quaternary ammonium salt compounds, and glycine surfactants. Alternatively, the antibacterial component of the present invention is at least one selected from macrolide compounds and azole compounds. These disinfectant or antibacterial ingredients kill the bacteria such as lysia that coexist in the body of the lice rather than the direct extermination effect on the lice, thereby cutting off the nutritional elements supplied by those bacteria and killing them indirectly. It has a good extermination effect.
消毒成分として、具体的には、ビクアナイト系化合物がグルコン酸クロルヘキシジン又はオラネキシジングルコン酸塩であり、フェノール系化合物がイソプロピルメチルフェノール、トリクロサン又はクロルキシレノールであり、四級アンモニウム塩化合物がベンザルコニウム塩化物、ベンゼトニウム塩化物、塩化セチルピリジニウム又はアクリノールであり、グリシン系界面活性剤が塩酸アルキルジアミノエチルグリシン又は塩酸アルキルポリアミノエチルグリシンであることなどが好ましい。そして、抗菌成分として、具体的には、アゾール系化合物がミコナゾール、ケトコナゾールであり、マクロライド系化合物がエリスロマイシン、クラリスロマイシン、イベルメクチン、エプリノメクチン、セラメクチン、ドラメクチン、ミルベマイシンオキシム、アベメクチン、モキシデクチン、アバメクチンであることなどが好ましい。これらの消毒成分又は抗菌成分は、１種又は２種以上組み合わせて使用することができる。また、このように例示した消毒成分又は抗菌成分は一例であり、同系統の化合物である限りにおいて他の消毒成分又は抗菌成分を使用することができる。 Specifically, as the disinfectant component, the biquanite compound is chlorhexidine gluconate or oranexidine lactate, the phenol compound is isopropylmethylphenol, triclosan or chlorxylenol, and the quaternary ammonium salt compound is benzalkonium. It is preferably chloride, benzethonium chloride, cetylpyridinium chloride or acrinol, and the glycine-based surfactant is alkyldiaminoethylglycine hydrochloride or alkylpolyaminoethylglycine hydrochloride. As antibacterial components, specifically, azole compounds are miconazole and ketoconazole, and macrolide compounds are erythromycin, clarithromycin, ivermectin, eprinomectin, selamectin, dramectin, milbemycin oxime, abemectin, moxidectin, and abamectin. That is preferable. These disinfectant components or antibacterial components can be used alone or in combination of two or more. Further, the disinfectant component or antibacterial component exemplified in this way is an example, and other disinfectant components or antibacterial components can be used as long as they are compounds of the same type.
本発明の消毒成分又は抗菌成分は、本発明のシラミ駆除剤である組成物中に、０．０２〜１０重量％含有することが好ましく、０．０３〜８重量％含有することがより好ましく、０．０５〜５重量％含有することが最も好ましい。消毒成分又は抗菌成分がこの範囲で配合されていると、シラミの体内に共生する細菌にも行き渡りその共生細菌を死滅させることによりシラミを駆除することができ、また、人体等の外皮に対して使用するときに刺激症状等を呈さず安全に使用することができる。 The disinfectant component or antibacterial component of the present invention is preferably contained in the composition of the lice repellent of the present invention in an amount of 0.02 to 10% by weight, more preferably 0.03 to 8% by weight. Most preferably, it is contained in an amount of 0.05 to 5% by weight. If a disinfectant or antibacterial ingredient is blended in this range, the lice can be exterminated by spreading to the bacteria that coexist in the body of the lice and killing the symbiotic bacteria, and also for the outer skin of the human body and the like. It can be used safely without exhibiting irritation symptoms when used.
上記消毒成分又は抗菌成分を希釈して均一溶液とするために水を配合することができる。水は、日本薬局方規格の水が好ましく、例えば、水道水、井戸水などである常水、そして、蒸留、イオン交換膜によるイオン交換処理、限外ろ過膜による限外ろ過処理のいずれか、またはそれらの組み合わせにより常水を処理した精製水、そして、加熱等により精製水を滅菌処理した滅菌精製水などが挙げられる。 Water can be added to dilute the disinfectant or antibacterial component into a uniform solution. The water is preferably water of the Japanese Pharmacy standard, for example, tap water, normal water such as well water, and either distillation, ion exchange treatment with an ion exchange membrane, ultrafiltration treatment with an ultrafiltration membrane, or Examples thereof include purified water obtained by treating normal water by a combination thereof, and sterilized purified water obtained by sterilizing purified water by heating or the like.
また、本発明のシラミ駆除剤を使用できるシラミの種類としては、種々のシラミを用いることができるが、人間に寄生するコロモジラミ、アタマジラミ、ケジラミに対して使用することが好ましい。このことから、本発明のシラミ駆除剤を所定の容器に入れ、スプレー製品やエアゾール製品などの噴霧製品として、人体の毛髪、絨毯、布製家具、布団、衣服などシラミが生息し得る箇所に用いることができる。 Further, as the type of lice to which the lice repellent of the present invention can be used, various lice can be used, but it is preferable to use them for body lice, head lice, and lice that parasitize humans. For this reason, the lice repellent of the present invention is placed in a predetermined container and used as a spray product such as a spray product or an aerosol product in a place where lice can inhabit such as human hair, carpet, cloth furniture, futon, and clothes. Can be done.
本発明のシラミ駆除剤には界面活性剤を配合することができる。界面活性剤を配合することにより、頭髪などに使用するシャンプーなどとしても処方することができるため、使用者にとっては、シラミ駆除剤だからといって特別な手間が掛かったり、特別な使い方をしたりするのではく、通常のシャンプーと区別することなく使用することができる。また、衣服などの洗浄剤として処方されたときには、使用者にとっては、同様に、通常の洗浄剤と区別することなく使用することができる。 A surfactant can be added to the lice repellent of the present invention. By blending a surfactant, it can be prescribed as a shampoo used for hair, etc., so for the user, even if it is a lice repellent, it may take special time and effort, or it may be used in a special way. It can be used without distinguishing it from ordinary shampoo. Further, when prescribed as a cleaning agent for clothes and the like, the user can similarly use it without distinguishing it from a normal cleaning agent.
本発明のシラミ駆除剤に配合することができる界面活性剤としては、カチオン界面活性剤、アニオン界面活性剤、両性界面活性剤、及び非イオン界面活性剤のうち少なくとも一種が配合されていることが好ましい。 As the surfactant that can be blended in the shirami repellent of the present invention, at least one of a cationic surfactant, an anionic surfactant, an amphoteric surfactant, and a nonionic surfactant is blended. preferable.
カチオン界面活性剤は、陽イオン性の親水基を有する界面活性剤であり、その中でも第４級アンモニウム塩型やアミン塩型などが好ましく、液状、又は固形である１００％純分の化合物だけでなく、それらを所定量の水で希釈した水溶液であってもよい。 The cationic surfactant is a surfactant having a cationic hydrophilic group, and among them, a quaternary ammonium salt type or an amine salt type is preferable, and only a liquid or solid 100% pure compound is used. However, it may be an aqueous solution obtained by diluting them with a predetermined amount of water.
第四級アンモニウム塩型のカチオン界面活性剤としては、４つの置換基に炭素数１〜２２の直鎖又は分岐鎖を有する炭化水素基、芳香族基及びそれらの組み合わせの置換基を備え、塩素イオン、臭化物イオンなどのハロゲン化イオンを対アニオンとして備えることが好ましい。また、炭化水素基は炭素数１〜１８の直鎖又は分岐鎖や飽和又は不飽和であってもよく、対アニオンとしては水酸化物イオン、リン系イオン、ホウ素系イオンであってもよい。具体的には、ラウリルトリメチルアンモニウムクロライド、ベンジルトリメチルアンモニウムクロライド、ベンジルトリエチルアンモニウムブロミド、テトラブチルアンモニウムヒドロキシド、テトラメチルアンモニウムブロミド、テトラブチルアンモニウムヨージド、ベンジルトリブチルアンモニウムクロライド、テトラブチルアンモニウムヘキサフルオロホスファート、テトラブチルアンモニウムテトラフルオロボラート、アルキルジメチルアンモニウムクロライドなどを使用することができる。 The quaternary ammonium salt type cationic surfactant includes a hydrocarbon group having a linear or branched chain having 1 to 22 carbon atoms, an aromatic group, and a combination of these substituents in four substituents, and chlorine. It is preferable to provide a halogenated ion such as an ion or a bromide ion as a counter anion. Further, the hydrocarbon group may be a linear or branched chain having 1 to 18 carbon atoms, saturated or unsaturated, and the counter anion may be a hydroxide ion, a phosphorus ion, or a boron ion. Specifically, lauryltrimethylammonium chloride, benzyltrimethylammonium chloride, benzyltriethylammonium bromide, tetrabutylammonium hydroxide, tetramethylammonium bromide, tetrabutylammonium iodide, benzyltributylammonium chloride, tetrabutylammonium hexafluorophosphate, Tetrabutylammonium tetrafluoroborate, alkyldimethylammonium chloride and the like can be used.
アミン塩型のカチオン界面活性剤としては、ココナットアミンアセテート、ステアリルアミンアセテートなどを使用することができる。 As the amine salt type cationic surfactant, coconut amine acetate, stearyl amine acetate and the like can be used.
アニオン界面活性剤は、陰イオン性の親水基を有する界面活性剤、アミノ酸型活性であり、その中でもカルボン酸型、スルホン酸型、硫酸エステル型、リン酸エステル型から選ばれる少なくとも１種が好ましく、液状、又は固形である１００％純分の化合物だけでなく、それらを所定量の水で希釈した水溶液であってもよい。 The anionic surfactant is a surfactant having an anionic hydrophilic group and an amino acid type activity, and among them, at least one selected from a carboxylic acid type, a sulfonic acid type, a sulfate ester type and a phosphoric acid ester type is preferable. It may be not only a 100% pure compound which is liquid or solid, but also an aqueous solution obtained by diluting them with a predetermined amount of water.
カルボン酸型のアニオン界面活性剤としては、炭素数１〜２２の直鎖又は分岐鎖を有する炭化水素基及びアシル基、ポリオキシアルキレン基、芳香族基並びにそれらの組み合わせの主鎖を有するカルボキシル基と、アルカリ金属、アルカリ土類金属などの金属との塩であることが好ましい。また、炭化水素基は炭素数１〜１８の直鎖又は分岐鎖や飽和又は不飽和であってもよい。具体的には、ラウリン酸ナトリウム、ステアリン酸ナトリウム、ラウレス−６カルボン酸ナトリウム（ポリオキシエチレン（４．５）ラウリルエーテル酢酸ナトリウム）、ラウロイルサルコシンナトリウム、オクタン酸ナトリウム、デカン酸ナトリウム、ミリスチリン酸ナトリウム、パルミチン酸ナトリウム、ヤシ油脂肪酸（Ｃ８〜１８）サルコンシンナトリウム、ヤシ油脂肪酸カリウムなどを使用することができる。 The carboxylic acid type anionic surfactant includes a hydrocarbon group having a linear or branched chain having 1 to 22 carbon atoms and an acyl group, a polyoxyalkylene group, an aromatic group, and a carboxyl group having a main chain of a combination thereof. And, preferably, it is a salt with a metal such as an alkali metal or an alkaline earth metal. Further, the hydrocarbon group may be a linear or branched chain having 1 to 18 carbon atoms, or may be saturated or unsaturated. Specifically, sodium laurate, sodium stearate, sodium laureth-6 carboxylate (polyoxyethylene (4.5) sodium lauryl ether acetate), sodium lauroyl sarcosine, sodium octanate, sodium decanoate, sodium myristylate, Sodium palmitate, coconut oil fatty acid (C8-18) sarconsin sodium, coconut oil fatty acid potassium and the like can be used.
スルホン酸型のアニオン界面活性剤としては、炭素数１〜２２の直鎖又は分岐鎖を有する炭化水素基及びアシル基、ポリオキシアルキレン基、芳香族基並びにそれらの組み合わせの主鎖を有するスルホニル基と、アルカリ金属、アルカリ土類金属などの金属との塩であることが好ましい。また、炭化水素基は炭素数１〜１８の直鎖又は分岐鎖や飽和又は不飽和であってもよい。具体的には、ラウリルスルホ酢酸ナトリウム、１−ヘキサンスルホン酸ナトリウム、１−オクタンスルホン酸ナトリウム、１−デカンスルホン酸ナトリウム、１−ドデカンスルホン酸ナトリウム、トルエンスルホン酸ナトリウム、クメンスルホン酸ナトリウム、ナフタレンスルホン酸ナトリウム、ナフタレンジスルホン酸二ナトリウム、ナフタレントリスルホン酸三ナトリウム、アルファオレフィンスルホン酸ナトリウム、ドデシルベンゼンスルホン酸ナトリウムなどを使用することができる。 The sulfonic acid type anionic surfactant includes a hydrocarbon group having a linear or branched chain having 1 to 22 carbon atoms and an acyl group, a polyoxyalkylene group, an aromatic group, and a sulfonyl group having a main chain of a combination thereof. It is preferably a salt with a metal such as an alkali metal or an alkaline earth metal. Further, the hydrocarbon group may be a linear or branched chain having 1 to 18 carbon atoms, or may be saturated or unsaturated. Specifically, sodium lauryl sulfoacetate, sodium 1-hexanesulfonate, sodium 1-octane sulfonate, sodium 1-decane sulfonate, sodium 1-dodecane sulfonate, sodium toluene sulfonate, sodium cumene sulfonate, naphthalene sulfone. Sodium acid, disodium naphthalenedisulfonate, trisodium naphthalenetrisulfonate, sodium alphaolefin sulfonate, sodium dodecylbenzenesulfonate and the like can be used.
硫酸エステル型のアニオン界面活性剤としては、炭素数１〜２２の直鎖又は分岐鎖を有する炭化水素基及びアシル基、ポリオキシアルキレン基、芳香族基並びにそれらの組み合わせの主鎖を有する硫酸基と、アルカリ金属、アルカリ土類金属などの金属との塩であることが好ましい。また、炭化水素基は炭素数１〜１８の直鎖又は分岐鎖や飽和又は不飽和であってもよい。具体的には、ラウリル硫酸ナトリウム、ミリスチル硫酸ナトリウム、ラウレス硫酸ナトリウム（ポリオキシエチレンラウリルエーテル硫酸ナトリウム）、セチル硫酸ナトリウム、ココグリセリル硫酸ナトリウム（硬化ヤシ油脂肪酸グリセリル硫酸ナトリウム）、ラウリル硫酸トリエタノールアミン、ラウリル硫酸アンモニウム、ラウレス硫酸トリエタノールアミンなどが好ましい。 As the sulfate ester type anionic surfactant, a hydrocarbon group having a linear or branched chain having 1 to 22 carbon atoms and an acyl group, a polyoxyalkylene group, an aromatic group, and a sulfate group having a main chain of a combination thereof. And, preferably, it is a salt with a metal such as an alkali metal or an alkaline earth metal. Further, the hydrocarbon group may be a linear or branched chain having 1 to 18 carbon atoms, or may be saturated or unsaturated. Specifically, sodium lauryl sulfate, sodium myristyl sulfate, sodium laureth sulfate (sodium polyoxyethylene lauryl ether sulfate), sodium cetyl sulfate, sodium cocoglyceryl sulfate (hardened coconut oil fatty acid sodium glyceryl sulfate), triethanolamine lauryl sulfate, Ammonium lauryl sulfate, triethanolamine laureth sulfate and the like are preferable.
リン酸エステル型のアニオン界面活性剤としては、炭素数１〜２２の直鎖又は分岐鎖を有する炭化水素基及びアシル基、ポリオキシアルキレン基、芳香族基並びにそれらの組み合わせの主鎖を有するリン酸基と、アルカリ金属、アルカリ土類金属などの金属との塩であることが好ましい。また、炭化水素基は炭素数１〜１８の直鎖又は分岐鎖や飽和又は不飽和であってもよい。具体的には、ラウリルリン酸ナトリウム、ポリオキシエチレンセチルエーテルリン酸ナトリウム（ポリオキシエチレン（５）セチルエーテルリン酸ナトリウム）、ラウリルリン酸、ラウリルリン酸カリウムなどを使用することができる。 Examples of the phosphoric acid ester type anionic surfactant include a hydrocarbon group having a linear or branched chain having 1 to 22 carbon atoms, an acyl group, a polyoxyalkylene group, an aromatic group, and phosphorus having a main chain of a combination thereof. It is preferably a salt of an acid group and a metal such as an alkali metal or an alkaline earth metal. Further, the hydrocarbon group may be a linear or branched chain having 1 to 18 carbon atoms, or may be saturated or unsaturated. Specifically, sodium lauryl phosphate, sodium polyoxyethylene cetyl ether phosphate (polyoxyethylene (5) sodium cetyl ether phosphate), lauryl phosphoric acid, potassium lauryl phosphate and the like can be used.
両性界面活性剤は、陰イオン性及び陽イオン性の親水基を両有する界面活性剤であり、その中でもアミンオキサイド型、ベタイン型から選ばれる少なくとも１種が好ましく、液状、又は固形である１００％純分の化合物だけでなく、それらを所定量の水で希釈した水溶液であってもよい。 The amphoteric tenside is a surfactant having both anionic and cationic hydrophilic groups, and at least one selected from amine oxide type and betaine type is preferable, and 100% which is liquid or solid. Not only the pure compounds, but also an aqueous solution obtained by diluting them with a predetermined amount of water may be used.
アミンオキサイド型の両性界面活性剤としては、炭素数１〜２２の直鎖又は分岐鎖を有する炭化水素基及びアシル基、ポリオキシアルキレン基、芳香族基並びにそれらの組み合わせの主鎖を有するアミンオキシド基であることが好ましい。また、炭化水素基は炭素数１〜１８の直鎖又は分岐鎖や飽和又は不飽和であってもよい。具体的には、ラウリルジメチルアミンオキサイド、アルキル（炭素数８〜１８）ジメチルアミンオキサイド（Ｎ，Ｎ−ジメチルアルキル（Ｃ８〜１８）アミンオキサイド）、ヤシアルキルジメチルアミンオキサイド、デシルジメチルアミンオキサイド、ミリスチルジメチルアミンオキサイド、ジヒドロキシエチルラウリルアミンオキサイド、オレイルジメチルアミンオキサイドなどを使用することができる。 As an amine oxide type amphoteric surfactant, an amine oxide having a main chain of a hydrocarbon group and an acyl group having a linear or branched chain having 1 to 22 carbon atoms, a polyoxyalkylene group, an aromatic group, and a combination thereof. It is preferably a group. Further, the hydrocarbon group may be a linear or branched chain having 1 to 18 carbon atoms, or may be saturated or unsaturated. Specifically, lauryldimethylamine oxide, alkyl (8-18 carbon atoms) dimethylamine oxide (N, N-dimethylalkyl (C8-18) amine oxide), coconut alkyldimethylamine oxide, decyldimethylamine oxide, myristyldimethyl. Amine oxide, dihydroxyethyllaurylamine oxide, oleyldimethylamine oxide and the like can be used.
ベタイン型の両性界面活性剤としては、炭素数１〜２２の直鎖又は分岐鎖を有する炭化水素基及びアシル基、ポリオキシアルキレン基、芳香族基並びにそれらの組み合わせの主鎖を有し、正電荷負電荷を同一分子内の隣合わない位置に有し分子全体として電荷を持たない化合物であることが好ましい。また、炭化水素基は炭素数１〜１８の直鎖又は分岐鎖や飽和又は不飽和であってもよい。具体的には、ラウリルジメチルアミノ酢酸ベタイン、ラウリルヒドロキシスルホベタイン、ステアリルジメチルアミノ酢酸ベタイン、ドデシルアミノメチルジメチルスルホプロピルベタイン、ヤシ油脂肪酸（Ｃ８〜１８）アミドプロピルベタイン、２−アルキル−Ｎ−カルボキシメチル−Ｎ−ヒドロキシエチルイミダゾリニウムベタイン、ラウリン酸アミドプロピルベタインなどを使用することができる。 The betaine-type amphoteric surfactant has a hydrocarbon group and an acyl group having a linear or branched chain having 1 to 22 carbon atoms, a polyoxyalkylene group, an aromatic group, and a main chain of a combination thereof, and is positive. Charge A compound having a negative charge at non-adjacent positions in the same molecule and having no charge as a whole molecule is preferable. Further, the hydrocarbon group may be a linear or branched chain having 1 to 18 carbon atoms, or may be saturated or unsaturated. Specifically, lauryldimethylaminoacetic acid betaine, laurylhydroxysulfobetaine, stearyldimethylaminoacetic acid betaine, dodecylaminomethyldimethylsulfopropyl betaine, coconut oil fatty acid (C8-18) amide propyl betaine, 2-alkyl-N-carboxymethyl. -N-Hydroxyethyl imidazolinium betaine, amidopropyl betaine laurate and the like can be used.
非イオン界面活性剤は、水に溶けたとき、イオン化しない親水基をもっている界面活性剤で、その中でもエステル型、エーテル型、エステルエーテル型などから選ばれる少なくとも一種が好ましく、液状、又は固形である１００％純分の化合物だけでなく、それらを所定量の水で希釈した水溶液であってもよい。 The nonionic surfactant is a surfactant having a hydrophilic group that does not ionize when dissolved in water, and among them, at least one selected from ester type, ether type, ester ether type and the like is preferable, and it is liquid or solid. Not only 100% pure compounds, but also an aqueous solution obtained by diluting them with a predetermined amount of water may be used.
エステル型の非イオン界面活性剤としては、炭素数１〜２２の直鎖又は分岐鎖を有する炭化水素基及びアシル基、芳香族基並びにそれらの組み合わせの主鎖を有するカルボン酸と多価アルコールから得られる化合物であることが好ましい。また、炭化水素基は炭素数１〜１８の直鎖又は分岐鎖や飽和又は不飽和であってもよい。具体的には、ソルビタンモノラウレート、ソルビタンモノパルミテート、ソルビタンモノステアレート、ソルビタンジステアレートなどのソルビタン脂肪酸エステル、グリセリンモノラウレート、グリセリンモノパルミテート、グリセリンモノステアレート、グリセリンジステアレートなどのグリセリン脂肪酸エステルなどを使用することができる。 Ester-type nonionic surfactants include hydrocarbon groups and acyl groups having linear or branched chains having 1 to 22 carbon atoms, aromatic groups, and carboxylic acids and polyhydric alcohols having the main chain of their combination. It is preferably the resulting compound. Further, the hydrocarbon group may be a linear or branched chain having 1 to 18 carbon atoms, or may be saturated or unsaturated. Specifically, sorbitan fatty acid esters such as sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan distearate, glycerin monolaurate, glycerin monopalmitate, glycerin monostearate, glycerin disstearate, etc. Glycerin fatty acid ester and the like can be used.
エーテル型の非イオン界面活性剤としては、炭素数１〜２２の直鎖又は分岐鎖を有する炭化水素基及びアシル基、芳香族基並びにそれらの組み合わせの主鎖を有する一価のアルコールと多価アルコールから得られる化合物であることが好ましい。また、炭化水素基は炭素数１〜１８の直鎖又は分岐鎖や飽和又は不飽和であってもよい。具体的には、ポリオキシエチレンラウリルエーテル、ポリオキシエチレンセチルエーテル、ポリオキシエチレンステアリルエーテル、ポリオキシエチレンオレイルエーテル、ポリオキシエチレンミリスチルエーテル、ポリオキシエチレンオクチルドデシルエーテル、ポリオキシエチレンポリオキシプロピレングリコールなどのポリオキシエチレンアルキルエーテル、ポリオキシエチレンアルキルアミン、ポリオキシエチレン硬化ヒマシ油などを使用することができる。 The ether type nonionic surfactant includes a hydrocarbon group having a linear or branched chain having 1 to 22 carbon atoms, an acyl group, an aromatic group, and a monohydric alcohol having a main chain of a combination thereof and polyhydric. It is preferably a compound obtained from alcohol. Further, the hydrocarbon group may be a linear or branched chain having 1 to 18 carbon atoms, or may be saturated or unsaturated. Specifically, polyoxyethylene lauryl ether, polyoxyethylene cetyl ether, polyoxyethylene stearyl ether, polyoxyethylene oleyl ether, polyoxyethylene myristyl ether, polyoxyethylene octyldodecyl ether, polyoxyethylene polyoxypropylene glycol, etc. Polyoxyethylene alkyl ether, polyoxyethylene alkylamine, polyoxyethylene cured castor oil and the like can be used.
エステルエーテル型の非イオン界面活性剤としては、炭素数１〜２２の直鎖又は分岐鎖を有する炭化水素基及びアシル基、芳香族基並びにそれらの組み合わせの主鎖を有するカルボン酸とポリアルキレンオキサイド又はポリアルキレンオキサイドが付加された多価アルコールから得られる化合物であることが好ましい。また、炭化水素基は炭素数１〜１８の直鎖又は分岐鎖や飽和又は不飽和であってもよい。具体的には、ポリオキシエチレンソルビタンモノラウレート、ポリオキシエチレンソルビタンモノパルミテート、ポリオキシエチレンソルビタンモノオレエートなどのポリオキシエチレンソルビタン脂肪酸エステル、ポリエチレングリコールモノラウレート、ポリエチレングリコールモノステアレートなどのポリオキシエチレン脂肪酸エステル、ポリオキシエチレングリセリンモノラウレート、ポリオキシエチレングリセリンモノパルミテート、ポリオキシエチレングリセリンモノオレエートなどのポリオキシエチレングリセリン脂肪酸エステルなどを使用することができる。 Ester ether type nonionic surfactants include hydrocarbon groups and acyl groups having linear or branched chains having 1 to 22 carbon atoms, aromatic groups, and carboxylic acids and polyalkylene oxides having the main chain of their combination. Alternatively, it is preferably a compound obtained from a polyhydric alcohol to which a polyalkylene oxide is added. Further, the hydrocarbon group may be a linear or branched chain having 1 to 18 carbon atoms, or may be saturated or unsaturated. Specifically, polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monopalmitate, and polyoxyethylene sorbitan monooleate, polyethylene glycol monolaurate, polyethylene glycol monostearate, and the like. Polyoxyethylene glycerin fatty acid esters such as polyoxyethylene fatty acid ester, polyoxyethylene glycerin monolaurate, polyoxyethylene glycerin monopalmitate, and polyoxyethylene glycerin monooleate can be used.
その他の非イオン界面活性剤として、エタノールアミンの構造を有するヤシ油脂肪酸ジエタノールアミドなどを使用することもできる。 As another nonionic surfactant, coconut oil fatty acid diethanolamide having an ethanolamine structure can also be used.
カチオン界面活性剤、アニオン界面活性剤、両性界面活性剤、及び、非イオン界面活性剤は１種類のみ、又は２種類以上組み合わせて用いることができる。そして、このうち、アニオン界面活性剤、両性界面活性剤、又は非イオン界面活性剤から選ばれる二種であることが好ましく、アニオン界面活性剤及び両性界面活性剤が組み合わせて用いられることがさらに好ましい。 The cationic surfactant, the anionic surfactant, the amphoteric surfactant, and the nonionic surfactant may be used alone or in combination of two or more. Of these, two types selected from anionic surfactants, amphoteric surfactants, and nonionic surfactants are preferable, and it is more preferable that anionic surfactants and amphoteric surfactants are used in combination. ..
カチオン界面活性剤、アニオン界面活性剤、両性界面活性剤、及び、非イオン界面活性剤の各界面活性剤は、本発明のシラミ駆除剤に０．１〜８０重量％配合されることが好ましく、０．５〜５０重量％配合されることがさらに好ましく、１〜３５重量％配合されることがもっとも好ましい。各界面活性剤の配合割合が上記の範囲であると、シラミの外皮に接触させたときに弾かれずに付着及び伸展しやすく消毒成分又は抗菌成分をシラミの体内に届けやすくなりシラミの駆除の効果が高くなるとともに、シャンプーなどとして頭髪や頭皮などに付着した皮脂などの汚れを落とした後に水で容易に洗い流すことができる。 Each of the cationic surfactant, the anionic surfactant, the amphoteric surfactant, and the nonionic surfactant is preferably blended in an amount of 0.1 to 80% by weight in the shaving agent of the present invention. It is more preferably blended in an amount of 0.5 to 50% by weight, and most preferably blended in an amount of 1 to 35% by weight. When the blending ratio of each surfactant is within the above range, it is easy to adhere and spread without being repelled when it comes into contact with the lice's scalp, and it becomes easy to deliver the disinfectant component or antibacterial component to the body of the lice, and the effect of exterminating the lice. It can be easily washed away with water after removing dirt such as sebum adhering to the hair and scalp as shampoo and the like.
さらに、本発明において、炭素数１〜２２の直鎖又は分岐鎖を有する炭化水素基及びアシル基、ポリオキシアルキレン基、芳香族基並びにそれらの組み合わせの主鎖を有するアルコールを配合することができる。また、炭化水素基は炭素数１〜１８の直鎖又は分岐鎖や飽和又は不飽和であってもよい。例えば、エタノール、ｎ−ブチルアルコール、イソブチルアルコール、ｓｅｃ−ブチルアルコール、ｔｅｒｔ−ブチルアルコール、ヘキサノール、ラウリルアルコール、ミリスチルアルコール、パルミチルアルコール、ステアリルアルコール、イソステアリルアルコール、オレイルアルコール、リノレイルアルコール、ベヘニルアルコールなどを用いることができる。なお、前記アルコールは１種類のみ、又は２種類以上組み合わせて用いることができる。 Further, in the present invention, an alcohol having a main chain of a hydrocarbon group and an acyl group having a linear or branched chain having 1 to 22 carbon atoms, a polyoxyalkylene group, an aromatic group and a combination thereof can be blended. .. Further, the hydrocarbon group may be a linear or branched chain having 1 to 18 carbon atoms, or may be saturated or unsaturated. For example, ethanol, n-butyl alcohol, isobutyl alcohol, sec-butyl alcohol, tert-butyl alcohol, hexanol, lauryl alcohol, myristyl alcohol, palmityl alcohol, stearyl alcohol, isostearyl alcohol, oleyl alcohol, linoleyl alcohol, behenyl alcohol, etc. Can be used. The alcohol may be used alone or in combination of two or more.
さらに製剤の酸化による劣化などの腐食を防止するため、ビタミンＣ（アスコルビン酸）、ビタミンＥ（α−トコフェロール）、ＢＨＴ（ジブチルヒドロキシトルエン）、ＢＨＡ（ブチルヒドロキシアニソール）、ソルビン酸、ソルビン酸カリウム、亜硫酸ナトリウムなどの酸化防止剤を添加することができる。また、防腐を目的に、パラオキシ安息香酸エステルなどを添加することもできる。また、抗炎症作用などを目的に、グリチルリチン酸二カリウムなどを添加することもできる。また、製剤のｐＨを調整することを目的に、リン酸緩衝液などを添加することもできる。 Furthermore, in order to prevent corrosion such as deterioration due to oxidation of the preparation, vitamin C (ascorbic acid), vitamin E (α-tocopherol), BHT (dibutylhydroxytoluene), BHA (butylhydroxyanisole), sorbic acid, potassium sorbate, Antioxidants such as sodium sulfite can be added. In addition, paraoxybenzoic acid ester and the like can be added for the purpose of preservative. In addition, dipotassium glycyrrhizinate or the like can be added for the purpose of anti-inflammatory action or the like. Further, a phosphate buffer solution or the like can be added for the purpose of adjusting the pH of the preparation.
さらに、爽快感を付与するためにｌ−メントールや、香りを付けるために種々の香料を添加することができる。 Further, l-menthol can be added to give a refreshing feeling, and various fragrances can be added to add a fragrance.
以下、本発明の実施例について具体的に説明する。なお、本発明は以下の実施例に限定されるものではない。 Hereinafter, examples of the present invention will be specifically described. The present invention is not limited to the following examples.
＜実施例１＞
グルコン酸クロルヘキシジン０．１７重量部、ポリオキシエチリレンラウリルエーテル硫酸ナトリウム３．３３重量部、ラウリン酸アミドプロピタルベタイン液０．８３重量部、ヤシ油脂肪酸ジエタノールアミド０．３３重量部、ポリオキシエチレン硬化ヒマシ油０．０５重量部、塩化Ｏ−［２−ヒドロキシ−３−（トリメチルアンモニオ）プロピル］ヒドロキシエチルセルロース０．０５重量部、プロピレングリコール１重量部、エデト酸２ナトリウム０．０３重量部、パラオキシ安息香酸エステル０．０５重量部、メチルポリシロキサン０．０８重量部、日本薬局方精製水９４．０８重量部を室温である２５℃において混合し、１００重量部のシラミ駆除剤を得た。
<Example 1>
Chlorhexidine gluconate 0.17 parts by weight, polyoxyethylylene lauryl ether sodium sulfate 3.33 parts by weight, lauric acid amide propital betaine solution 0.83 parts by weight, coconut oil fatty acid diethanolamide 0.33 parts by weight, polyoxyethylene 0.05 parts by weight of hardened castor oil, 0.05 parts by weight of O- [2-hydroxy-3- (trimethylammonio) propyl] hydroxyethyl cellulose, 1 part by weight of propylene glycol, 0.03 parts by weight of disodium edetate, 0.05 parts by weight of paraoxybenzoic acid ester, 0.08 parts by weight of methylpolysiloxane, and 94.08 parts by weight of purified water manufactured by the Japanese Pharmacy were mixed at 25 ° C. at room temperature to obtain 100 parts by weight of a shirami repellent.
＜実施例２＞
グルコン酸クロルヘキシジン０．０８重量部、ポリオキシエチリレンラウリルエーテル硫酸ナトリウム３．３３重量部、ラウリン酸アミドプロピタルベタイン液０．８３重量部、ヤシ油脂肪酸ジエタノールアミド０．３３重量部、ポリオキシエチレン硬化ヒマシ油０．０５重量部、塩化Ｏ−［２−ヒドロキシ−３−（トリメチルアンモニオ）プロピル］ヒドロキシエチルセルロース０．０５重量部、プロピレングリコール１重量部、エデト酸２ナトリウム０．０３重量部、パラオキシ安息香酸エステル０．０５重量部、メチルポリシロキサン０．０８重量部、日本薬局方精製水９４．１７重量部を室温である２５℃において混合し、１００重量部のシラミ駆除剤を得た。
<Example 2>
Chlorhexidine gluconate 0.08 parts by weight, polyoxyethylylene lauryl ether sodium sulfate 3.33 parts by weight, lauric acid amide propital betaine solution 0.83 parts by weight, coconut oil fatty acid diethanolamide 0.33 parts by weight, polyoxyethylene 0.05 parts by weight of hardened castor oil, 0.05 parts by weight of O- [2-hydroxy-3- (trimethylammonio) propyl] hydroxyethyl cellulose, 1 part by weight of propylene glycol, 0.03 parts by weight of disodium edetate, 0.05 parts by weight of paraoxybenzoic acid ester, 0.08 parts by weight of methylpolysiloxane, and 94.17 parts by weight of purified water manufactured by the Japanese Pharmacy were mixed at 25 ° C. at room temperature to obtain 100 parts by weight of a shirami repellent.
＜実施例３＞
ベンザルコニウム塩化物０．１７重量部、ポリオキシエチリレンラウリルエーテル硫酸ナトリウム３．３３重量部、ラウリン酸アミドプロピタルベタイン液０．８３重量部、ヤシ油脂肪酸ジエタノールアミド０．３３重量部、ポリオキシエチレン硬化ヒマシ油０．０５重量部、塩化Ｏ−［２−ヒドロキシ−３−（トリメチルアンモニオ）プロピル］ヒドロキシエチルセルロース０．０５重量部、プロピレングリコール１重量部、エデト酸２ナトリウム０．０３重量部、パラオキシ安息香酸エステル０．０５重量部、メチルポリシロキサン０．０８重量部、日本薬局方精製水９４．０８重量部を室温である２５℃において混合し、１００重量部のシラミ駆除剤を得た。
<Example 3>
0.17 parts by weight of benzalconium chloride, 3.33 parts by weight of polyoxyethylylene lauryl ether sodium sulfate, 0.83 parts by weight of lauric acid amide propital betaine solution, 0.33 parts by weight of coconut oil fatty acid diethanolamide, poly 0.05 parts by weight of oxyethylene hydrogenated castor oil, 0.05 parts by weight of O- [2-hydroxy-3- (trimethylammonio) propyl] hydroxyethyl cellulose, 1 part by weight of propylene glycol, 0.03 parts by weight of disodium edetate Parts, 0.05 parts by weight of paraoxybenzoic acid ester, 0.08 parts by weight of methylpolysiloxane, and 94.08 parts by weight of purified water from Japan Pharmacy were mixed at 25 ° C. at room temperature to obtain 100 parts by weight of a shirami repellent. It was.
＜実施例４＞
ベンザルコニウム塩化物０．０８重量部、ポリオキシエチリレンラウリルエーテル硫酸ナトリウム３．３３重量部、ラウリン酸アミドプロピタルベタイン液０．８３重量部、ヤシ油脂肪酸ジエタノールアミド０．３３重量部、ポリオキシエチレン硬化ヒマシ油０．０５重量部、塩化Ｏ−［２−ヒドロキシ−３−（トリメチルアンモニオ）プロピル］ヒドロキシエチルセルロース０．０５重量部、プロピレングリコール１重量部、エデト酸２ナトリウム０．０３重量部、パラオキシ安息香酸エステル０．０５重量部、メチルポリシロキサン０．０８重量部、日本薬局方精製水９４．１７重量部を室温である２５℃において混合し、１００重量部のシラミ駆除剤を得た。
<Example 4>
0.08 parts by weight of benzalconium chloride, 3.33 parts by weight of polyoxyethylylene lauryl ether sodium sulfate, 0.83 parts by weight of lauric acid amide propital betaine solution, 0.33 parts by weight of coconut oil fatty acid diethanolamide, poly 0.05 parts by weight of oxyethylene hydrogenated castor oil, 0.05 parts by weight of O- [2-hydroxy-3- (trimethylammonio) propyl] hydroxyethyl cellulose, 1 part by weight of propylene glycol, 0.03 parts by weight of disodium edetate Parts, 0.05 parts by weight of paraoxybenzoic acid ester, 0.08 parts by weight of methylpolysiloxane, and 94.17 parts by weight of purified water from Japan Pharmacy were mixed at 25 ° C. at room temperature to obtain 100 parts by weight of a shirami repellent. It was.
＜実施例５＞
ベンゼトニウム塩化物０．１７重量部、ポリオキシエチリレンラウリルエーテル硫酸ナトリウム３．３３重量部、ラウリン酸アミドプロピタルベタイン液０．８３重量部、ヤシ油脂肪酸ジエタノールアミド０．３３重量部、ポリオキシエチレン硬化ヒマシ油０．０５重量部、塩化Ｏ−［２−ヒドロキシ−３−（トリメチルアンモニオ）プロピル］ヒドロキシエチルセルロース０．０５重量部、プロピレングリコール１重量部、エデト酸２ナトリウム０．０３重量部、パラオキシ安息香酸エステル０．０５重量部、メチルポリシロキサン０．０８重量部、日本薬局方精製水９４．０８重量部を室温である２５℃において混合し、１００重量部のシラミ駆除剤を得た。
<Example 5>
0.17 parts by weight of benzethonium chloride, 3.33 parts by weight of polyoxyethylylene lauryl ether sodium sulfate, 0.83 parts by weight of lauric acid amide propital betaine solution, 0.33 parts by weight of coconut oil fatty acid diethanolamide, polyoxyethylene 0.05 parts by weight of hardened castor oil, 0.05 parts by weight of O- [2-hydroxy-3- (trimethylammonio) propyl] hydroxyethyl cellulose, 1 part by weight of propylene glycol, 0.03 parts by weight of disodium edetate, 0.05 parts by weight of paraoxybenzoic acid ester, 0.08 parts by weight of methylpolysiloxane, and 94.08 parts by weight of purified water manufactured by the Japanese Pharmacy were mixed at 25 ° C. at room temperature to obtain 100 parts by weight of a shirami repellent.
＜実施例６＞
ベンゼトニウム塩化物０．０８重量部、ポリオキシエチリレンラウリルエーテル硫酸ナトリウム３．３３重量部、ラウリン酸アミドプロピタルベタイン液０．８３重量部、ヤシ油脂肪酸ジエタノールアミド０．３３重量部、ポリオキシエチレン硬化ヒマシ油０．０５重量部、塩化Ｏ−［２−ヒドロキシ−３−（トリメチルアンモニオ）プロピル］ヒドロキシエチルセルロース０．０５重量部、プロピレングリコール１重量部、エデト酸２ナトリウム０．０３重量部、パラオキシ安息香酸エステル０．０５重量部、メチルポリシロキサン０．０８重量部、日本薬局方精製水９４．１７重量部を室温である２５℃において混合し、１００重量部のシラミ駆除剤を得た。
<Example 6>
0.08 parts by weight of benzethonium chloride, 3.33 parts by weight of polyoxyethylylene lauryl ether sodium sulfate, 0.83 parts by weight of lauric acid amide propital betaine solution, 0.33 parts by weight of coconut oil fatty acid diethanolamide, polyoxyethylene 0.05 parts by weight of hardened castor oil, 0.05 parts by weight of O- [2-hydroxy-3- (trimethylammonio) propyl] hydroxyethyl cellulose, 1 part by weight of propylene glycol, 0.03 parts by weight of disodium edetate, 0.05 parts by weight of paraoxybenzoic acid ester, 0.08 parts by weight of methylpolysiloxane, and 94.17 parts by weight of purified water manufactured by the Japanese Pharmacy were mixed at 25 ° C. at room temperature to obtain 100 parts by weight of a shirami repellent.
＜実施例７＞
塩化セチルピリジニウム０．１７重量部、ポリオキシエチリレンラウリルエーテル硫酸ナトリウム３．３３重量部、ラウリン酸アミドプロピタルベタイン液０．８３重量部、ヤシ油脂肪酸ジエタノールアミド０．３３重量部、ポリオキシエチレン硬化ヒマシ油０．０５重量部、塩化Ｏ−［２−ヒドロキシ−３−（トリメチルアンモニオ）プロピル］ヒドロキシエチルセルロース０．０５重量部、プロピレングリコール１重量部、エデト酸２ナトリウム０．０３重量部、パラオキシ安息香酸エステル０．０５重量部、メチルポリシロキサン０．０８重量部、日本薬局方精製水９４．０８重量部を室温である２５℃において混合し、１００重量部のシラミ駆除剤を得た。
<Example 7>
0.17 parts by weight of cetylpyridinium chloride, 3.33 parts by weight of polyoxyethylylene lauryl ether sodium sulfate, 0.83 parts by weight of lauric acid amide propital betaine solution, 0.33 parts by weight of coconut oil fatty acid diethanolamide, polyoxyethylene 0.05 parts by weight of hardened castor oil, 0.05 parts by weight of O- [2-hydroxy-3- (trimethylammonio) propyl] hydroxyethyl cellulose, 1 part by weight of propylene glycol, 0.03 parts by weight of disodium edetate, 0.05 parts by weight of paraoxybenzoic acid ester, 0.08 parts by weight of methylpolysiloxane, and 94.08 parts by weight of purified water manufactured by the Japanese Pharmacy were mixed at 25 ° C. at room temperature to obtain 100 parts by weight of a shirami repellent.
＜実施例８＞
塩化セチルピリジニウム０．０８重量部、ポリオキシエチリレンラウリルエーテル硫酸ナトリウム３．３３重量部、ラウリン酸アミドプロピタルベタイン液０．８３重量部、ヤシ油脂肪酸ジエタノールアミド０．３３重量部、ポリオキシエチレン硬化ヒマシ油０．０５重量部、塩化Ｏ−［２−ヒドロキシ−３−（トリメチルアンモニオ）プロピル］ヒドロキシエチルセルロース０．０５重量部、プロピレングリコール１重量部、エデト酸２ナトリウム０．０３重量部、パラオキシ安息香酸エステル０．０５重量部、メチルポリシロキサン０．０８重量部、日本薬局方精製水９４．１７重量部を室温である２５℃において混合し、１００重量部のシラミ駆除剤を得た。
<Example 8>
0.08 parts by weight of cetylpyridinium chloride, 3.33 parts by weight of polyoxyethylylene lauryl ether sodium sulfate, 0.83 parts by weight of lauric acid amide propital betaine solution, 0.33 parts by weight of coconut oil fatty acid diethanolamide, polyoxyethylene 0.05 parts by weight of hardened castor oil, 0.05 parts by weight of O- [2-hydroxy-3- (trimethylammonio) propyl] hydroxyethyl cellulose, 1 part by weight of propylene glycol, 0.03 parts by weight of disodium edetate, 0.05 parts by weight of paraoxybenzoic acid ester, 0.08 parts by weight of methylpolysiloxane, and 94.17 parts by weight of purified water manufactured by the Japanese Pharmacy were mixed at 25 ° C. at room temperature to obtain 100 parts by weight of a shirami repellent.
＜実施例９＞
イソプロピルメチルフェノール０．１７重量部、ポリオキシエチリレンラウリルエーテル硫酸ナトリウム３．３３重量部、ラウリン酸アミドプロピタルベタイン液０．８３重量部、ヤシ油脂肪酸ジエタノールアミド０．３３重量部、ポリオキシエチレン硬化ヒマシ油０．０５重量部、塩化Ｏ−［２−ヒドロキシ−３−（トリメチルアンモニオ）プロピル］ヒドロキシエチルセルロース０．０５重量部、プロピレングリコール１重量部、エデト酸２ナトリウム０．０３重量部、パラオキシ安息香酸エステル０．０５重量部、メチルポリシロキサン０．０８重量部、日本薬局方精製水９４．０８重量部を室温である２５℃において混合し、１００重量部のシラミ駆除剤を得た。
<Example 9>
0.17 parts by weight of isopropylmethylphenol, 3.33 parts by weight of polyoxyethylylene lauryl ether sodium sulfate, 0.83 parts by weight of lauric acid amide propital betaine solution, 0.33 parts by weight of coconut oil fatty acid diethanolamide, polyoxyethylene 0.05 parts by weight of hardened castor oil, 0.05 parts by weight of O- [2-hydroxy-3- (trimethylammonio) propyl] hydroxyethyl cellulose, 1 part by weight of propylene glycol, 0.03 parts by weight of disodium edetate, 0.05 parts by weight of paraoxybenzoic acid ester, 0.08 parts by weight of methylpolysiloxane, and 94.08 parts by weight of purified water manufactured by the Japanese Pharmacy were mixed at 25 ° C. at room temperature to obtain 100 parts by weight of a shirami repellent.
＜実施例１０＞
イソプロピルメチルフェノール０．０８重量部、ポリオキシエチリレンラウリルエーテル硫酸ナトリウム３．３３重量部、ラウリン酸アミドプロピタルベタイン液０．８３重量部、ヤシ油脂肪酸ジエタノールアミド０．３３重量部、ポリオキシエチレン硬化ヒマシ油０．０５重量部、塩化Ｏ−［２−ヒドロキシ−３−（トリメチルアンモニオ）プロピル］ヒドロキシエチルセルロース０．０５重量部、プロピレングリコール１重量部、エデト酸２ナトリウム０．０３重量部、パラオキシ安息香酸エステル０．０５重量部、メチルポリシロキサン０．０８重量部、日本薬局方精製水９４．１７重量部を室温である２５℃において混合し、１００重量部のシラミ駆除剤を得た。
<Example 10>
0.08 parts by weight of isopropylmethylphenol, 3.33 parts by weight of polyoxyethylylene lauryl ether sodium sulfate, 0.83 parts by weight of lauric acid amide propital betaine solution, 0.33 parts by weight of coconut oil fatty acid diethanolamide, polyoxyethylene 0.05 parts by weight of hardened castor oil, 0.05 parts by weight of O- [2-hydroxy-3- (trimethylammonio) propyl] hydroxyethyl cellulose, 1 part by weight of propylene glycol, 0.03 parts by weight of disodium edetate, 0.05 parts by weight of paraoxybenzoic acid ester, 0.08 parts by weight of methylpolysiloxane, and 94.17 parts by weight of purified water manufactured by the Japanese Pharmacy were mixed at 25 ° C. at room temperature to obtain 100 parts by weight of a shirami repellent.
＜実施例１１＞
ミコナゾール０．１７重量部、ポリオキシエチリレンラウリルエーテル硫酸ナトリウム３．３３重量部、ラウリン酸アミドプロピタルベタイン液０．８３重量部、ヤシ油脂肪酸ジエタノールアミド０．３３重量部、ポリオキシエチレン硬化ヒマシ油０．０５重量部、塩化Ｏ−［２−ヒドロキシ−３−（トリメチルアンモニオ）プロピル］ヒドロキシエチルセルロース０．０５重量部、プロピレングリコール１重量部、エデト酸２ナトリウム０．０３重量部、パラオキシ安息香酸エステル０．０５重量部、メチルポリシロキサン０．０８重量部、日本薬局方精製水９４．０８重量部を室温である２５℃において混合し、１００重量部のシラミ駆除剤を得た。
<Example 11>
0.17 parts by weight of myconazole, 3.33 parts by weight of polyoxyethylylene lauryl ether sodium sulfate, 0.83 parts by weight of lauric acid amide propital betaine solution, 0.33 parts by weight of coconut oil fatty acid diethanolamide, polyoxyethylene hydrogenated sunflower 0.05 parts by weight of oil, 0.05 parts by weight of O- [2-hydroxy-3- (trimethylammonio) propyl] hydroxyethyl cellulose, 1 part by weight of propylene glycol, 0.03 parts by weight of disodium edetate, paraoxybenzo 0.05 parts by weight of the acid ester, 0.08 parts by weight of the methyl polysiloxane, and 94.08 parts by weight of purified water manufactured by the Japanese Pharmacy were mixed at 25 ° C. at room temperature to obtain 100 parts by weight of a shirami repellent.
＜実施例１２＞
ミコナゾール０．０８重量部、ポリオキシエチリレンラウリルエーテル硫酸ナトリウム３．３３重量部、ラウリン酸アミドプロピタルベタイン液０．８３重量部、ヤシ油脂肪酸ジエタノールアミド０．３３重量部、ポリオキシエチレン硬化ヒマシ油０．０５重量部、塩化Ｏ−［２−ヒドロキシ−３−（トリメチルアンモニオ）プロピル］ヒドロキシエチルセルロース０．０５重量部、プロピレングリコール１重量部、エデト酸２ナトリウム０．０３重量部、パラオキシ安息香酸エステル０．０５重量部、メチルポリシロキサン０．０８重量部、日本薬局方精製水９４．１７重量部を室温である２５℃において混合し、１００重量部のシラミ駆除剤を得た。
<Example 12>
0.08 parts by weight of myconazole, 3.33 parts by weight of polyoxyethylylene lauryl ether sodium sulfate, 0.83 parts by weight of lauric acid amide propital betaine solution, 0.33 parts by weight of coconut oil fatty acid diethanolamide, polyoxyethylene hydrogenated sunflower 0.05 parts by weight of oil, 0.05 parts by weight of O- [2-hydroxy-3- (trimethylammonio) propyl] hydroxyethyl cellulose, 1 part by weight of propylene glycol, 0.03 parts by weight of disodium edetate, paraoxybenzo 0.05 parts by weight of the acid ester, 0.08 parts by weight of the methyl polysiloxane, and 94.17 parts by weight of purified water manufactured by the Japanese Pharmacy were mixed at 25 ° C. at room temperature to obtain 100 parts by weight of a shirami repellent.
＜比較例１＞
日本薬局方精製水１００重量部を比較対象とした。
<Comparative example 1>
100 parts by weight of purified water of the Japanese Pharmacopoeia was used as a comparison target.
＜比較例２＞
ポリオキシエチリレンラウリルエーテル硫酸ナトリウム３．３３重量部、ラウリン酸アミドプロピタルベタイン液０．８３重量部、ヤシ油脂肪酸ジエタノールアミド０．３３重量部、ポリオキシエチレン硬化ヒマシ油０．０５重量部、塩化Ｏ−［２−ヒドロキシ−３−（トリメチルアンモニオ）プロピル］ヒドロキシエチルセルロース０．０５重量部、プロピレングリコール１重量部、エデト酸２ナトリウム０．０３重量部、パラオキシ安息香酸エステル０．０５重量部、メチルポリシロキサン０．０８重量部、日本薬局方精製水９４．２５重量部を室温である２５℃において混合し、１００重量部のシラミ駆除剤を得た。
<Comparative example 2>
3.33 parts by weight of polyoxyethylylene lauryl ether sodium sulfate, 0.83 parts by weight of lauric acid amide propital betaine solution, 0.33 parts by weight of palm oil fatty acid diethanolamide, 0.05 parts by weight of polyoxyethylene hydrogenated castor oil, O- [2-Hydroxy-3- (trimethylammonio) propyl] hydroxyethyl cellulose 0.05 parts by weight, propylene glycol 1 part by weight, disodium edetate 0.03 parts by weight, paraoxybenzoic acid ester 0.05 parts by weight , 0.08 parts by weight of methylpolysiloxane and 94.25 parts by weight of purified water according to the Japanese Pharmacopoeia were mixed at 25 ° C. at room temperature to obtain 100 parts by weight of a shirami repellent.
〔駆除率〕
得られたシラミ駆除剤等の駆除率については、コロモジラミを用いて以下の試験方法で確認した。すなわち、２０匹のコロモジラミをシャーレに入れ、そこに各実施例及び各比較例で得られたシラミ駆除剤に当該シラミを５分間浸漬させ処理した後に引き上げ、１分間水で洗い流した後、２４時間経過後の状態を観察した。２４時間経過後に観察し、動き回り生存している匹数（生存数）と、静止しており死亡またはそれに準じる状態の匹数（死虫数）を数え、駆除率（％）＝｛死虫数／（生存数＋死虫数）｝×１００で記載される計算式より効力を百分率により駆除率を算出した。この駆除率が、５０％未満の場合を駆除効果なし、５０％以上７０％未満を駆除効果あり、７０％以上を十分に駆除効果ありと判断した。表１に各実施例及び比較例の配合及び効果を示す。
[Extermination rate]
The extermination rate of the obtained lice exterminating agent and the like was confirmed by the following test method using body lice. That is, 20 body lice were placed in a petri dish, and the lice were immersed in the lice repellents obtained in each Example and each comparative example for 5 minutes, treated, pulled up, rinsed with water for 1 minute, and then washed for 24 hours. The state after the lapse was observed. Observe after 24 hours, count the number of animals that are moving around and alive (number of survivors) and the number of animals that are stationary and dead or similar (number of dead insects), and the extermination rate (%) = {number of dead insects The extermination rate was calculated by the percentage of efficacy from the formula described by / (number of survivors + number of dead insects)} × 100. When the extermination rate was less than 50%, it was judged that there was no extermination effect, 50% or more and less than 70% had an extermination effect, and 70% or more was judged to have a sufficient extermination effect. Table 1 shows the formulations and effects of each Example and Comparative Example.
表１に示すように、実施例１〜１２では、試験に供した２０匹のコロモジラミのうち最終的に７０％以上のシラミが死滅などにより全く動かなくなり駆除することができた。これは、コロモジラミの体内に共生するリーシアという共生細菌が消毒成分又は抗菌成分により死滅し、宿主であるコロモジラミにビタミンＢ群の供給などができなくなったためにコロモジラミが最終的に死滅などして全く動かくなったと推察される。また、一方で、これらの消毒成分又は抗菌成分を有しない水のみである比較例１では、シラミを全く駆除することができず、また、先行特許文献１のような界面活性剤による窒息作用を有するシャンプーでは十分な駆除効果を得られなかった。このことから、シラミを駆除する有効成分として消毒成分又は抗菌成分が作用し、シラミに対して高い駆除効果を発現することが明らかとなった。 As shown in Table 1, in Examples 1 to 12, 70% or more of the 20 body lice used in the test were finally killed and could be exterminated. This is because the symbiotic bacterium called lysia, which coexists in the body of the body lice, is killed by the disinfectant component or antibacterial component, and the host body lice can no longer supply the B vitamins, so the body lice finally die and move completely. It is presumed that it has become. On the other hand, in Comparative Example 1 in which only water does not have these disinfectant components or antibacterial components, lice cannot be exterminated at all, and the choking action of a surfactant as in Prior Patent Document 1 is exhibited. A sufficient extermination effect could not be obtained with the shampoo possessed. From this, it was clarified that a disinfectant component or an antibacterial component acts as an active ingredient for exterminating lice and exhibits a high extermination effect on lice.
Claims (4)
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