JP2002114656A - Base material for composition for oral cavity and composition for oral cavity - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a base material for a composition for the oral cavity suitable for manufacturing the composition for the oral cavity, especially a nonaqueous composition for the oral cavity; and to obtain a composition for the oral cavity prepared by stably compounding an active ingredient which is usually unstable in the presence of water, especially a nonaqueous composition for the oral cavity. SOLUTION: The base material for the nonaqueous composition for the oral cavity contains at lest one kind selected from agar and gelatin, and at least one kind selected from glycerol, diglycerin, propylene glycol and polyethylene glycol; a composition for the oral cavity contains the base material for the composition for the oral cavity; a composition for the oral cavity contains the base material for the composition for the oral cavity and calcium α-phosphate tribasic (α-TCP); a composition for the oral cavity contains the base material for the composition for the oral cavity and at least one kind fluorine compound; a composition for the oral cavity contains the base material for the composition for the oral cavity and an enzyme; and a composition for the oral cavity contains the base material for the composition for the oral cavity and at least one kind selected from the group consisting of hinokitiol, ascorbic acid, a derivative of ascorbic acid and ε-aminocaproic acid.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an oral composition base, and more particularly to an oral composition suitable for producing an oral composition containing no or almost no water. Regarding the base. The present invention further relates to an oral composition containing such an oral composition base.

[0002]

2. Description of the Related Art Oral compositions such as dentifrices generally contain an adhesive such as sodium carboxymethylcellulose, carrageenan or xanthan gum. A powder component and a liquid component, such as an agent, are combined to give shape retention properties or moderate viscosity. Therefore, in oral compositions such as dentifrices that do not contain water, since viscosity does not appear, it is difficult to maintain shape retention, and in oral compositions, the powder component and the liquid component are separated over time. Get up.

On the other hand, oral compositions such as dentifrices have functions and
For the purpose of imparting efficacy, various active ingredients may be added to the preparation, and as the active ingredients, remineralization promoting ingredients,
Examples include fluorides, bactericides, anti-inflammatory agents, hemostatic agents, various enzymes, and the like. Examples of the remineralization promoting component include calcium phosphate compounds such as hydroxyapatite, and among them, α-tricalcium phosphate (abbreviated as α-TCP) has a very high remineralization promoting effect in the oral cavity, and prevents dental caries. It is known to be effective for restoration and the like. However, α-TCP has the property of converting to an apatite compound in the presence of water, and the reaction is accelerated by the presence of fluoride or other water-soluble calcium phosphate, causing a self-hardening reaction. It could not be stably incorporated into oral compositions such as preparations.

[0004] Specific examples of the fluoride include sodium fluoride, monofluorophosphate, potassium fluoride, sodium monofluorophosphate, tin fluoride, and the like. The purpose is to fluorinate apatite to strengthen the tooth. When fluoride is blended into oral compositions such as dentifrice containing ordinary water, fluoride ions dissolve into water in the oral composition and are adsorbed to other components such as abrasives, and the original effect of fluorine ions May not be exhibited. For example, in an oral composition containing water in which an abrasive such as sodium phosphate or tin fluoride and an abrasive such as calcium phosphate or calcium carbonate are blended, fluorine ions may be absorbed by the abrasive and inactivate the fluorine ions. Are known.

Examples of the enzyme include lysozyme, mutanase, protease, amylase, dextranase and the like having a lytic action and a proteolytic action. Most of these enzymes are hydrolyzed when incorporated in a composition containing water. However, there is a problem that the enzyme activity is reduced. Therefore, when blending an enzyme with a composition containing water, it is necessary to select an enzyme that is unlikely to undergo hydrolysis or to search for a method of stable blending for each enzyme individually.

In addition, hinokitiol as a natural bactericide, ascorbic acid derivatives such as ascorbic acid and sodium ascorbate as anti-inflammatory agents, and ε-aminocaproic acid as a hemostatic agent may be added to oral compositions such as dentifrices. However, when these active ingredients are added to a composition containing water, the quantitative value tends to decrease due to hydrolysis. All of these problems relating to the stability of the active ingredient result from the fact that water is contained in oral compositions such as dentifrices. Therefore, the above-mentioned α-TCP, fluoride, various enzymes, ascorbic acid and an ascorbic acid derivative, hinokitiol and ε-aminocaproic acid can be stably blended, and in oral compositions such as dentifrice containing almost no water. There is a need for an oral composition having a shape retention property and a composition in which a powder component and a liquid component do not separate over time.

[0007]

SUMMARY OF THE INVENTION An object of the present invention is to provide an oral composition suitable for producing an oral composition, particularly an oral composition containing no or almost no water. The purpose is to provide a base for use. Another object of the present invention is to provide an oral composition which has excellent shape retention and is stable over time without causing separation of components, and which is advantageous for producing an oral composition containing no or almost no water. The purpose is to provide a base for the composition. It is a further object of the present invention to provide a base for an oral composition which can stably incorporate an active ingredient which is normally unstable in the presence of water. A further object of the present invention is to provide an oral composition stably containing an active ingredient which is normally unstable in the presence of water, particularly an oral composition containing no or almost no water. is there.

[0008]

Means for Solving the Problems The inventors of the present invention have conducted intensive studies in order to achieve the above-mentioned object, and as a result, by using a base for an oral composition having a specific composition, a highly stable oral composition was obtained. The present inventors have found that it is possible to provide a composition for use, and have completed the present invention. Accordingly, the present invention relates to a base for a non-aqueous oral composition, which comprises at least one selected from agar and gelatin, and at least one selected from glycerin, diglycerin, propylene glycol and polyethylene glycol. . The present invention also relates to an oral composition comprising the above-mentioned base for an oral composition. As used herein, the term "non-aqueous oral composition" refers to an oral composition having a water content of 0 to 2% by mass, preferably 0 to 1% by mass, and more preferably no water, based on the entire oral composition. Composition. Further, a base suitable for producing such a non-aqueous oral composition is herein referred to as a non-aqueous oral composition base.

[0009] The present invention also relates to an oral composition comprising the above-mentioned base for oral composition and α-tricalcium phosphate (α-TCP). The present invention relates to an oral composition characterized by containing the above-mentioned base for an oral composition and at least one fluoride. The present invention also relates to an oral composition comprising the above-mentioned base for oral composition and enzymes. The present invention further provides the above-mentioned base for an oral composition, hinokitiol, ascorbic acid, an ascorbic acid derivative and ε-
At least one selected from the group consisting of aminocaproic acid
An oral composition characterized by containing a seed.
Further, the present invention provides the above-mentioned base for oral composition, and α-T
An oral composition containing at least one selected from CP, fluoride, enzymes, hinokitiol, ascorbic acid, ascorbic acid derivative and ε-aminocaproic acid is also included. As a preferred embodiment of the oral composition of the present invention, there is an oral composition in which α-TCP and fluoride are combined with the above-mentioned oral composition base.

[0010]

BEST MODE FOR CARRYING OUT THE INVENTION The term "oral composition" as used herein refers to dentifrices such as toothpastes, liquid dentifrices and lubricating dentifrices, creams, ointments, attachments, mouth fresheners , Mouthwash, chewing gum or gargle. The oral compositions of the present invention are desirably directed to non-aqueous oral compositions.

The agar to be used as the base for the oral composition of the present invention is obtained by freeze-drying mucus obtained from maxa (Tengusa), other congener plants or various red alga. The form of the agar is a translucent white powder, granules or flakes, such as tetrahedral, flocculent or scaly flakes. Such agar is widely and generally used in foods, cosmetics, pharmaceuticals, miscellaneous goods, and the like. In the present invention, commercially available products can be used. When agar is used, the content of agar in the oral composition is suitably from 0.01 to 30% by mass, and preferably from 1 to 10% by mass, based on the total mass of the oral composition. If the amount is less than 0.01% by mass, the expected effect of the pressure-sensitive adhesive will not be exhibited, while if it exceeds 30% by mass, the usability may be impaired.

The gelatin used for the base for the oral composition of the present invention is a gelatin obtained by treating a bone, a skin, a ligament or a tendon of an animal with an acid or an alkali and extracting the crude collagen by heating with water. It is. Gelatin forms include powders, flakes,
There are small pieces and grains. Such gelatin is widely and generally used in foods, cosmetics, pharmaceuticals, miscellaneous goods, and the like. In the present invention, commercially available products can be used. When gelatin is used, the content of gelatin in the oral composition is suitably from 0.01 to 30% by mass, preferably from 1 to 30% by mass, based on the total mass of the oral composition.
10% by mass. If the amount is less than 0.01% by mass, the expected effect of the pressure-sensitive adhesive will not be exhibited, while if it exceeds 30% by mass, the usability may be impaired. The base for the oral composition or the composition for the oral cavity of the present invention may be used in combination with agar and gelatin, and the total amount thereof is 0.02 to 30% by mass based on the total mass of the oral composition. Suitable
Preferably it is 1 to 10% by mass.

The concentrated glycerin, diglycerin, propylene glycol and polyethylene glycol used in the base for the oral composition of the present invention are widely used in a wide variety of fields such as pharmaceuticals and cosmetics, foods, sundries, petrochemical industry, and paint industry. What is used. In the present invention, commercially available products can be used. Particularly preferred are concentrated glycerin and diglycerin. The content of at least one selected from concentrated glycerin, diglycerin, propylene glycol and polyethylene glycol in the oral composition is suitably 1 to 70% by mass, preferably 10% by mass, based on the total mass of the oral composition. ５０50% by mass.
If the amount is less than 1% by mass or exceeds 70% by mass, the usability may be impaired.

The base for the oral composition of the present invention includes
Various components such as additives and active ingredients used in the oral composition can be combined into the oral composition.
The base for oral compositions of the present invention is particularly advantageous for combination with components which are usually unstable in the presence of water. Such components include α-TCP, fluoride, enzymes, hinokitiol, ascorbic acid, ascorbic acid derivatives, ε-aminocaproic acid, and the like.

Α-TCP used in the present invention is α-tricalcium phosphate (3Ca ₃ (PO ₄ ) ₂ .Ca (O
H) ₂ ), which is widely and generally used in medicine, cosmetics, food, sundries, and petrochemical industries. In the present invention, commercially available products can be used. The content of α-TCP in the oral composition of the present invention is suitably from 0.1 to 50% by mass, and preferably from 1 to 30% by mass, based on the total mass of the oral composition. If this amount is less than 0.1% by mass, the expected re-rocking effect is not exhibited, while if it exceeds 50% by mass, the usability may be impaired. When α-TCP is blended, when a fluoride is further used in combination, the supply of fluorine ions is added to the remineralization action, so that an extremely excellent effect is exhibited. Therefore, a combination of α-TCP and a fluoride described later is preferably used.

Specific examples of the fluoride used in the present invention include sodium fluoride, monofluorophosphate, potassium fluoride, sodium monofluorophosphate, tin fluoride and the like. At least one of these is used. be able to. These fluorides are widely and generally used in pharmaceuticals and cosmetics. In the present invention, commercially available products can be used. The content of fluoride in the oral composition of the present invention is suitably from 0.01 to 3% by mass based on the total mass of the oral composition, and preferably as fluorine in the oral composition such as a dentifrice. The content is 1000 ppm or less. As the fluoride, sodium fluoride and sodium monofluorophosphate are preferable.

Specific examples of the enzymes used in the oral composition of the present invention include lysozyme, mutanase, protease, amylase, dextranase and the like. One or more of these may be used. it can.
These enzymes are widely and generally used in pharmaceuticals, cosmetics, foods and the like. In the present invention, commercially available products can be used. The enzyme content in the oral composition of the present invention is 0.01 to 5 with respect to the total mass of the oral composition.
% Is suitable, preferably 0.1 to 2% by weight. Lysozyme and amylase are preferred as enzymes.

Hinokitiol is a specific component contained in natural trees, Aomori Hiba, and is a crystalline acidic compound.
Examples of other tree species containing hinokitiol include hinoki cypress, western red cedar from North America, and the like. Hinokitiol has a strong antibacterial activity and a broad antibacterial spectrum, and is one of the few natural fungicides. Such hinokitiol is widely used widely, including foods and cosmetics, pharmaceuticals, agricultural supplies, building materials, baits, etc., and in the present invention, commercially available products used for these can be used. . The content of hinokitiol in the oral composition of the present invention is suitably from 0.005 to 0.5% by mass, preferably from 0.01 to 0.2% by mass, based on the total mass of the oral composition. is there.

Ascorbic acid refers to vitamin C, and ascorbic acid derivatives refer to compounds formed by a change in a small part in the ascorbic acid molecule. Ascorbic acid-2 is a specific example of an ascorbic acid derivative.
-Phosphate, ascorbic acid-3-phosphate, ascorbic acid-6-phosphate, ascorbic acid-2-polyphosphate, ascorbic acid-2-
Sulfate phosphate, ascorbic acid-2-palmitate, ascorbic acid-2-stearate, ascorbic acid 2,6-dibutyl ester and the like. Examples of the salts include sodium salts, potassium salts, calcium salts, and magnesium salts. One or more of these can be used. As ascorbic acid derivatives, sodium ascorbate,
Ascorbic acid-2-phosphate and ascorbic acid-3-phosphate are preferred. These ascorbic acid and ascorbic acid derivatives are components having an anti-inflammatory effect, and are widely and generally used in cosmetics, pharmaceuticals, foods, agricultural products, and the like. In the present invention, commercially available products can be used. The content of ascorbic acid and / or ascorbic acid derivative in the composition for oral cavity of the present invention is 0.0% based on the total mass of the composition for oral cavity.
It is suitably from 0.01 to 20% by mass, preferably from 0.01 to 20% by mass.
10% by mass.

Ε-Aminocaproic acid is a component having an antiplasmin effect, a hemostatic effect, and an anti-inflammatory effect, and is widely and generally used in cosmetics, pharmaceuticals, foods, agricultural products, and the like. In the present invention, commercially available products can be used. The content of ε-aminocaproic acid in the oral composition of the present invention is appropriately 0.001 to 1% by mass, preferably 0.006 to 0.2% by mass based on the total mass of the oral composition. It is.

As described above, α-T is an active ingredient suitable for combination with the base for an oral composition of the present invention.
CP; fluoride; enzymes; hinokitiol; ascorbic acid and its derivatives; and ε-aminocaproic acid. One or two of these compounds are
More than one species can be selected and included, and compounds can be selected from two or more groups, not limited to one group, and used in combination. Among them, a combination of α-TCP and fluoride is preferable.

The oral composition of the present invention may contain, in addition to the above components, the following components, if necessary, within the usual range of use, depending on the type of the composition. <Abrasives> Silica gel, precipitated silica, igneous silica,
Silica-based abrasives such as hydrous silicic acid, silicic anhydride, zeolite, aluminosilicate, zirconosilicate, dibasic calcium phosphate dihydrate, dibasic calcium phosphate anhydrate, calcium pyrophosphate, tertiary magnesium phosphate,
Aluminum hydroxide, alumina, light calcium carbonate,
Examples thereof include heavy calcium carbonate, magnesium carbonate, zirconium silicate, and a synthetic resin-based abrasive, and one or more of these can be used in combination.
The compounding amount of the above-mentioned abrasive is preferably 3 to 60% by mass, more preferably 10 to 45% by mass, based on the whole composition.

<Wetting agent> sorbitol, maltitol,
One or more polyhydric alcohols such as 1,3-butylene glycol can be used. <Blowing agent> sodium lauryl sulfate, sodium lauroyl sarcosine, sodium alkyl sulfosuccinate,
Coconut oil fatty acid sodium monoglycerol sulfonate, α
-Sodium olefin sulfonate, N-acyl amino acid salts such as N-acyl glutamate, 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, maltitol fatty acid ester, sucrose fatty acid ester, polyglycerin fatty acid Esters, fatty acid diethanolamide, polyoxyethylene sorbitan monostearate, polyoxyethylene hydrogenated castor oil, polyoxyethylene fatty acid esters and the like.
Species or a combination of two or more can be used.

<Sweetener> Saccharin sodium, aspartame, trehalose, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl dihydrochalcone, perillartin, etc. <Preservatives> Parabens such as methylparaben, ethylparaben, propylparaben, and butylparaben, sodium benzoate, phenoxyethanol, and alkyldiaminoethylglycine hydrochloride.

<Fragrance ingredients> l-menthol, anethole,
One or more of menthone, cineol, limonene, carvone, methyl salicylate, ethyl butyrate, eugenol, thymol, cinamic aldehyde, trans-2-hexenal and the like can be used in combination. These components may be compounded individually,
Essential oils containing these may be blended. Further, in addition to the above flavor components, aliphatic alcohols and esters thereof, terpene hydrocarbons, phenol ethers, aldehydes,
Perfume components such as ketones and lactones, and essential oils may be blended as long as the effects of the present invention are not impaired. The amount of the above fragrance is
The content is preferably set to 0.02 to 2% by mass based on the whole composition.

<Active ingredients> Polyvinylpyrrolidone, zeolite, chlorhexidine salts, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, bisabolol, triclosan, isopropylmethylphenol, tocopherol acetate, tranexamic acid, dihydrocholesterol, glycyrrhetinic acid, glycyrrhizinates , Copper chlorophyllin salt, sodium chloride, guaiazulene sulfonate, pyridoxine hydrochloride, or the like, and one or more thereof can be blended.

<Others> Dyes such as Blue No. 1, pigments such as titanium oxide, antioxidants such as dibutylhydroxytoluene, tea distilled water, and flavoring agents such as sodium glutamate. When water is blended in the oral composition of the present invention in a range of 2% by mass or less depending on the type, the following binders can be blended, if necessary, in addition to the above components. <Binder> carrageenan (ι, λ, κ), alginic acid,
Alginate and its derivatives such as sodium alginate, propylene glycol alginate, sodium alginate containing calcium, potassium alginate, calcium alginate, ammonium alginate, xanthan gum, guar gum, sodium carboxymethyl cellulose, hydroxyethyl cellulose, sodium polyacrylate and the like. One or more of them can be used in combination.

The oral composition comprising the above components can be produced according to a conventional method, and is not particularly limited. The obtained oral composition such as toothpaste can be used after being filled in an aluminum tube, a laminated tube, a glass deposition tube, a plastic tube, a plastic bottle, an aerosol container, or the like.

[0029]

According to the specific oral composition base of the present invention containing at least one selected from agar and gelatin and at least one of concentrated glycerin, diglycerin, propylene glycol and polyethylene glycol, A non-aqueous oral composition having shape retention and high stability can be obtained. Further, the base for the oral composition of the present invention, α which is an active ingredient which is usually unstable in the presence of water
-Combination of TCP, fluoride, various enzymes, hinokitiol, ascorbic acid, ascorbic acid derivative, ε-aminocaproic acid, etc. It is possible to obtain a non-aqueous oral composition which is stable over time and does not cause separation.

[0030]

EXAMPLES Hereinafter, the present invention will be described in detail with reference to experimental examples and comparative examples, but the present invention is not limited to the following examples. Various toothpastes were prepared by the usual method using the compositions (unit: mass%) shown in Tables 1 to 4, and subjected to the following tests. <Toothpaste storage stability test> After preparing the dentifrice shown in Table 1,
Severe storage was performed under the following conditions. After the severe storage, the condition of each dentifrice was visually evaluated according to the following evaluation criteria. “Severe storage conditions” 1. Store in a 60 ° C constant temperature bath for 1 month 2. Store in a 50 ° C constant temperature bath for 2 months “Evaluation criteria” ○: The condition is the same as immediately after preparation. X: Separation was confirmed.

<Fluorine ion measurement test> After preparing the dentifrices shown in Table 2, they were subjected to severe storage under the following conditions. After the severe storage, a fixed amount of each dentifrice was weighed, dispersed in water, immediately centrifuged, and separated into a liquid layer and a solid layer. For these liquid layer portions, the fluorine ion concentration was measured using a fluorine ion meter. The detected fluorine ions are considered to be active fluorine ions which are not adsorbed to other components in the dentifrice. "Severe storage conditions" 1. Storage in a 60 ° C constant temperature bath for 1 week 2. Storage in a 60 ° C constant temperature bath for 2 weeks “Formula (1)” Residual rate (%) = [(Fluorine ion after the above severe storage Amount) / (amount of fluorine ion at the time of dentifrice preparation)] × 100 In the severely preserved dentifrice, the fluorine ion residual ratio,
That is, when the active fluorine ion was 80% or more, the fluoride was determined to be stable.

<Sodium Ascorbate Quantitative Test> After the dentifrices shown in Table 3 were prepared, they were subjected to severe storage under the following conditions. After the end of severe storage, a quantitative test was performed on sodium ascorbate in each dentifrice by a liquid chromatographic method. In addition, the residual rate of sodium ascorbate was calculated from the formula (2). "Severe storage conditions" 1. Store in a 60 ° C constant temperature bath for 1 month 2. Store in a 50 ° C constant temperature bath for 2 months “Formula (2)” Residual rate (%) = [( Sodium ascorbate) / (amount of sodium ascorbate at the time of dentifrice adjustment)] × 100 In the severely preserved dentifrice, when the residual ratio of sodium ascorbate is 90% or more, sodium ascorbate is stable. Was determined.

<Quantitative test of ε-aminocaproic acid> After preparing the dentifrices shown in Table 4, they were subjected to severe storage under the following conditions.
After the severe storage, a quantitative test was performed on ε-aminocaproic acid in each dentifrice by liquid chromatography.
In addition, the residual ratio of ε-aminocaproic acid was determined from Expression (3). “Severe storage conditions” 1. Store in a 60 ° C constant temperature bath for 1 month 2. Store in a 50 ° C constant temperature bath for 2 months “Formula (3)” Residual rate (%) = [( (amount of ε-aminocaproic acid) / (amount of ε-aminocaproic acid at the time of preparation of dentifrice)] × 100 In the severely preserved dentifrice, when the residual ratio of ε-aminocaproic acid is 90% or more, ε- Aminocaproic acid was determined to be stable. Further, the state stability of the dentifrices of Examples 4 to 12 in severe storage was maintained.

[0034]

[Table 1]

[0035]

[Table 2]

[0036]

[Table 3]

[0037]

[Table 4]

From the above experimental results, it can be seen from Table 1 that the use of the oral composition base of the present invention does not cause any separation in the state of the toothpaste and has excellent storage stability. Further, from Tables 2 to 4, it can be seen that the toothpaste which is the oral composition of the present invention has excellent storage stability of fluoride, sodium ascorbate and ε-aminocaproic acid. In addition, when the above-mentioned experiments were carried out for the following Examples 13 to 21, all the same results were obtained. Further, with respect to Examples 22 to 27, tests were conducted on the storage stability of α-TCP, the enzyme and hinokitiol, and it was found that the storage stability was also excellent.
Examples will be described below. The unit of the composition is% by mass.

[0039]

Example 13 Toothpaste Calcium pyrophosphate 30.0 Silicic anhydride 5.0 Agar 1.0 Concentrated glycerin 38.0 Sorbit powder 20.7 Sodium fluoride 1.0 Polyoxyethylene hydrogenated castor oil 3.0 Paraben 0 .1 Perfume 1.0 Tocopherol acetate 0.1 Cetylpyridinium chloride 0.1 Total 100.0%

[0040]

Example 14 Toothpaste Calcium pyrophosphate 30.0 Heavy calcium carbonate 10.0 Silicic anhydride 10.0 Agar 1.0 Concentrated glycerin 45.6 Ascorbic acid 0.1 Polyoxyethylene hydrogenated castor oil 3.0 Paraben 0.1 β-glycyrrhetinic acid 0.1 Tocopherol acetate 0.1 Total 100.0%

[0041]

Example 15 Toothpaste Calcium pyrophosphate 30.0 Silicic anhydride 10.0 Agar 1.0 Concentrated glycerin 40.5 Propylene glycol 11.3 Sodium lauryl sulfate 1.0 ε-Aminocaproic acid 0.1 Paraben 0.1 Fragrance 1.0 Sodium chloride 5.0 Total 100.0%

[0042]

Example 16 Toothpaste Calcium phosphate for dentifrice 35.0 Silicic anhydride 10.0 Agar 1.0 Concentrated glycerin 40.0 Polyethylene glycol 11.2 Sodium fluoride 1.0 Sodium ascorbate 0.1 Sodium lauryl sulfate 0.5 Stevia extract 0.1 Paraben 0.1 Perfume 1.0 Total 100.0%

[0043]

Example 17 Toothpaste Calcium phosphate for dentifrice 35.0 Silicic anhydride 10.0 Concentrated glycerin 37.7 Sorbit powder 10.0 Agar 1.0 Sodium fluoride 0.2 ε-Aminocaproic acid 0.1 Polyoxy Ethylene hydrogenated castor oil 3.0 Xylitol 1.0 Sodium benzoate 1.0 Fragrance 1.0 Total 100.0%

[0044]

Example 18 Toothpaste Calcium phosphate for dentifrice 30.0 Silicic anhydride 10.0 Agar 1.0 Concentrated glycerin 36.0 Propylene glycol 12.0 Sodium lauryl sulfate 0.8 Sodium ascorbate 0.1 ε-Aminocaprone Acid 0.1 Polyoxyethylene hydrogenated castor oil 3.0 Xylitol 5.0 Sodium benzoate 1.0 Fragrance 1.0 Total 100.0%

[0045]

Example 19 Toothpaste Calcium pyrophosphate 30.0 Silicic anhydride 5.0 Gelatin 1.0 Concentrated glycerin 38.0 Sorbit powder 20.7 Sodium fluoride 1.0 Polyoxyethylene hydrogenated castor oil 3.0 Paraben 0 .1 Perfume 1.0 Tocopherol acetate 0.1 Cetylpyridinium chloride 0.1 Total 100.0%

[0046]

Example 20 Toothpaste Calcium pyrophosphate 30.0 Heavy calcium carbonate 10.0 Silicic anhydride 10.0 Agar 1.0 Concentrated glycerin 45.6 Sodium ascorbate 0.1 Polyoxyethylene hydrogenated castor oil 3.0 Paraben 0.1 Glycyrrhizic acid 0.1 Chlorhexidine gluconate 0.1 Total 100.0%

[0047]

Example 21 Toothpaste Calcium hydrogen phosphate for dentifrice 25.0 Silicic anhydride 10.0 Diglycerin 34.0 Polyethylene glycol 15.0 Agar 1.0 Gelatin 1.0 Sodium lauryl sulfate 1.7 Ascorbic acid Sodium 0.2 ε-aminocaproic acid 0.1 Polyoxyethylene hydrogenated castor oil 3.0 Xylitol 7.0 Sodium benzoate 1.0 Perfume 1.0 Total 100.0%

[0048]

Example 22 Toothpaste Calcium hydrogen phosphate for dentifrice 30.0 Silicic anhydride 5.0 Agar 1.0 Concentrated glycerin 38.8 Sorbit powder 11.0 α-TCP 10.0 Polyoxyethylene hydrogenated castor oil 3.0 Paraben 0.1 Perfume 1.0 Tocopherol acetate 0.1 Total 100.0%

[0049]

Example 23 Toothpaste Calcium pyrophosphate 30.0 Silicic anhydride 10.0 Calcium bicarbonate 10.0 Agar 1.0 Concentrated glycerin 30.0 Diglycerin 14.7 Hinokitiol 0.1 Polyoxyethylene hydrogenated castor oil 3 1.0 Paraben 0.1 Fragrance 1.0 Dipotassium glycyrrhizinate 0.1 Total 100.0%

[0050]

Example 24 Toothpaste Calcium pyrophosphate 30.0 Heavy calcium carbonate 10.0 Silicic anhydride 5.0 Agar 1.0 Concentrated glycerin 37.3 α-TCP 5.0 Sodium ascorbate 0.1 Lysozyme chloride 0 1.5 Paraben 0.1 Fragrance 1.0 Sodium chloride 10.0 Total 100.0%

[0051]

Example 25 Toothpaste Calcium phosphate for dentifrice 35.0 Silicic anhydride 10.0 Agar 1.0 Gelatin 1.0 Concentrated glycerin 39.0 Polyethylene glycol 12.0 Sodium fluoride 0.2 Mutanase 0.1 Lauryl Sodium sulfate 0.5 Stevia extract 0.1 Paraben 0.1 Flavor 1.0 Total 100.0%

[0052]

Example 26 Toothpaste Calcium hydrogen phosphate for dentifrice 30.0 Silicic anhydride 5.0 Agar 1.0 Gelatin 1.0 Polyethylene glycol 30.0 Propylene glycol 15.0 Sodium lauryl sulfate 0.9 α-TCP 5.0 Hinokitiol 0.1 Polyoxyethylene hydrogenated castor oil 3.0 Xylitol 7.0 Sodium benzoate 1.0 Perfume 1.0 Total 100.0%

[0053]

Example 27 Toothpaste Calcium hydrogen phosphate for dentifrice 30.0 Heavy calcium carbonate 10.0 Agar 3.0 Concentrated glycerin 40.4 α-TCP 5.0 Sodium fluoride 0.5 Xylitol 10.0 Paraben 0.1 perfume 1.0 total 100.0%

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Claims (9)

[Claims] 1. A non-aqueous oral composition comprising at least one selected from agar and gelatin and at least one selected from the group consisting of glycerin, diglycerin, propylene glycol and polyethylene glycol. Base. 2. An oral composition comprising the oral composition base of claim 1. 3. An oral composition comprising the oral composition base of claim 1 and α-tricalcium phosphate (α-TCP). 4. An oral composition comprising the base for an oral composition according to claim 1 and at least one fluoride. 5. The oral composition according to claim 3, further comprising at least one fluoride. 6. An oral composition comprising the base for an oral composition according to claim 1 and enzymes. 7. The oral composition according to any one of claims 3 to 5, further comprising enzymes. 8. An oral cavity comprising the base for an oral composition according to claim 1, and at least one member selected from the group consisting of hinokitiol, ascorbic acid, an ascorbic acid derivative, and ε-aminocaproic acid. Composition. 9. The composition for oral cavity according to claim 3, further comprising at least one selected from the group consisting of hinokitiol, ascorbic acid, an ascorbic acid derivative and ε-aminocaproic acid.