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JO3221B1 - مركبات حمض داي ميثيل - بنزويك مفيدة لعلاج الحالات الالتهابية - Google Patents

مركبات حمض داي ميثيل - بنزويك مفيدة لعلاج الحالات الالتهابية

Info

Publication number
JO3221B1
JO3221B1 JOP/2013/0178A JOP20130178A JO3221B1 JO 3221 B1 JO3221 B1 JO 3221B1 JO P20130178 A JOP20130178 A JO P20130178A JO 3221 B1 JO3221 B1 JO 3221B1
Authority
JO
Jordan
Prior art keywords
dimethyl
treatment
benzoic acid
acid compounds
compounds useful
Prior art date
Application number
JOP/2013/0178A
Other languages
English (en)
Inventor
Natali Vetman Tatiana
Lee Kuklish Steven
Joseph Fisher Matthew
Blanco-Pillado Maria-Jesus
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of JO3221B1 publication Critical patent/JO3221B1/ar

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40Oxygen atoms
    • C07D211/42Oxygen atoms attached in position 3 or 5
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40Oxygen atoms
    • C07D211/44Oxygen atoms attached in position 4
    • C07D211/46Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10Spiro-condensed systems
    • C07D491/113Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)

Abstract

يوفر الاختراع الحالي مركب وفقًا للصيغة II: حيث A هي: R1 هي CH3، CF3، أو F؛ R2 هي H، CH3، أو F؛ R3 هي CH3، OCH3، OH، F؛ R4 هي OH أو CH2OH؛ و X هي CH أو N؛ أو ملح مقبول صيدليًا منه.
JOP/2013/0178A 2012-06-29 2013-06-13 مركبات حمض داي ميثيل - بنزويك مفيدة لعلاج الحالات الالتهابية JO3221B1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261665956P 2012-06-29 2012-06-29
US201361778969P 2013-03-13 2013-03-13

Publications (1)

Publication Number Publication Date
JO3221B1 true JO3221B1 (ar) 2018-03-08

Family

ID=48746667

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2013/0178A JO3221B1 (ar) 2012-06-29 2013-06-13 مركبات حمض داي ميثيل - بنزويك مفيدة لعلاج الحالات الالتهابية

Country Status (41)

Country Link
US (2) US8642768B2 (ar)
EP (1) EP2867218B1 (ar)
JP (1) JP6114824B2 (ar)
KR (1) KR101634032B1 (ar)
CN (1) CN104334540B (ar)
AP (1) AP4063A (ar)
AR (1) AR091431A1 (ar)
AU (1) AU2013280779B2 (ar)
BR (1) BR112014029551A2 (ar)
CA (1) CA2875572C (ar)
CL (1) CL2014003537A1 (ar)
CO (1) CO7160064A2 (ar)
CR (1) CR20140554A (ar)
CY (1) CY1118830T1 (ar)
DK (1) DK2867218T3 (ar)
DO (1) DOP2014000286A (ar)
EA (1) EA025531B1 (ar)
ES (1) ES2623099T3 (ar)
GT (1) GT201400289A (ar)
HK (1) HK1203936A1 (ar)
HR (1) HRP20170540T1 (ar)
HU (1) HUE032398T2 (ar)
IL (1) IL236218A (ar)
IN (1) IN2014MN02356A (ar)
JO (1) JO3221B1 (ar)
LT (1) LT2867218T (ar)
ME (1) ME02655B (ar)
MX (1) MX347476B (ar)
MY (1) MY172860A (ar)
NZ (1) NZ701894A (ar)
PE (1) PE20150185A1 (ar)
PH (1) PH12015500008A1 (ar)
PL (1) PL2867218T3 (ar)
PT (1) PT2867218T (ar)
RS (1) RS55756B1 (ar)
SG (1) SG11201408629QA (ar)
SI (1) SI2867218T1 (ar)
TN (1) TN2014000500A1 (ar)
TW (1) TWI572597B (ar)
WO (1) WO2014004230A1 (ar)
ZA (1) ZA201408631B (ar)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110015221A1 (en) * 2003-12-23 2011-01-20 Pierre Fabre Medicament Pharmaceutical composition of vinflunine which is intended for parenteral administration preparation method thereof and use of same
TWI572597B (zh) * 2012-06-29 2017-03-01 美國禮來大藥廠 二甲基-苯甲酸化合物
EP2765128A1 (en) * 2013-02-07 2014-08-13 Almirall, S.A. Substituted benzamides with activity towards EP4 receptors
TWI636046B (zh) 2013-05-17 2018-09-21 美國禮來大藥廠 苯氧基乙基二氫-1h-異喹啉化合物
CN105793236B (zh) 2013-12-17 2017-10-10 伊莱利利公司 二甲基苯甲酸化合物
WO2016037954A1 (de) * 2014-09-09 2016-03-17 Bayer Pharma Aktiengesellschaft Substituierte n,2-diarylchinolin-4-carboxamide und ihre anti-inflammatorische verwendung
CR20180323A (es) 2015-11-20 2018-08-06 Idorsia Pharmaceuticals Ltd Derivados de indol n-sustituídos como moduladores de los receptores de pge2
MX2019012153A (es) * 2017-04-10 2019-11-21 Bayer Ag N-ariletil-2-arilquinolina -4-carboxamidas sustituidas y su uso.
TWI770157B (zh) * 2017-04-10 2022-07-11 德商拜耳廠股份有限公司 經取代之n-芳基乙基-2-胺基喹啉-4-甲醯胺及其用途
KR102612649B1 (ko) 2017-05-18 2023-12-11 이도르시아 파마슈티컬스 리미티드 Pge2 수용체 조절제로서의 벤조푸란 및 벤조티오페논 유도체
HRP20211532T1 (hr) 2017-05-18 2022-01-07 Idorsia Pharmaceuticals Ltd N-supstituirani derivati indola
PE20191814A1 (es) 2017-05-18 2019-12-27 Idorsia Pharmaceuticals Ltd Derivados de pirimidina como moduladores del receptor de pge2
TW201900180A (zh) 2017-05-18 2019-01-01 瑞士商愛杜西亞製藥有限公司 嘧啶衍生物
JP7159215B2 (ja) 2017-05-18 2022-10-24 イドーシア ファーマシューティカルズ リミテッド Pge2レセプター調節剤としてのピリミジン誘導体
JPWO2022102731A1 (ar) 2020-11-13 2022-05-19

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1270615B (it) 1994-07-14 1997-05-07 Smithkline Beecham Farma Uso di derivati di chinolina
JP2000355551A (ja) * 1999-06-15 2000-12-26 Nikken Chem Co Ltd 医薬組成物
MXPA06003123A (es) 2003-09-22 2006-05-31 Euro Celtique Sa Agentes terapeuticos utiles para el tratamiento del dolor.
WO2005080367A1 (en) 2004-02-12 2005-09-01 Pharmagene Laboratories Limited Ep2 receptor agonists
JP5183628B2 (ja) * 2006-06-12 2013-04-17 メルク カナダ インコーポレイテッド Ep4受容体リガンドとしてのインドリンアミド誘導体
CA2681861A1 (en) * 2007-03-26 2008-10-16 Astellas Pharma Inc. Ornithine derivative
WO2012004293A2 (de) 2010-07-08 2012-01-12 Bayer Cropscience Ag Insektizide und fungizide wirkstoffkombinationen
JP2014514257A (ja) 2011-03-03 2014-06-19 ユニバーシテーテ デス ザールランデス 選択的17ベータ−ヒドロキシステロイドデヒドロゲナーゼ2型阻害剤としてのビアリール誘導体
TWI572597B (zh) * 2012-06-29 2017-03-01 美國禮來大藥廠 二甲基-苯甲酸化合物

Also Published As

Publication number Publication date
AU2013280779B2 (en) 2015-09-10
KR20150013335A (ko) 2015-02-04
IL236218A (en) 2017-12-31
NZ701894A (en) 2016-09-30
AP2014008165A0 (en) 2014-12-31
EA201492140A1 (ru) 2015-10-30
EP2867218A1 (en) 2015-05-06
JP2015522589A (ja) 2015-08-06
BR112014029551A2 (pt) 2017-06-27
US20140005222A1 (en) 2014-01-02
AR091431A1 (es) 2015-02-04
SI2867218T1 (sl) 2017-04-26
HRP20170540T1 (hr) 2017-06-16
EA025531B1 (ru) 2017-01-30
PH12015500008B1 (en) 2015-03-02
MX347476B (es) 2017-04-27
CN104334540B (zh) 2016-03-16
WO2014004230A1 (en) 2014-01-03
AP4063A (en) 2017-03-09
KR101634032B1 (ko) 2016-06-27
ME02655B (me) 2017-06-20
IL236218A0 (en) 2015-02-01
US8642768B2 (en) 2014-02-04
MY172860A (en) 2019-12-12
US20140094491A1 (en) 2014-04-03
CN104334540A (zh) 2015-02-04
CA2875572A1 (en) 2014-01-03
ES2623099T3 (es) 2017-07-10
HUE032398T2 (en) 2017-09-28
PH12015500008A1 (en) 2015-03-02
HK1203936A1 (en) 2015-11-06
TWI572597B (zh) 2017-03-01
CA2875572C (en) 2016-03-22
PT2867218T (pt) 2017-04-19
CO7160064A2 (es) 2015-01-15
PE20150185A1 (es) 2015-02-13
LT2867218T (lt) 2017-04-25
JP6114824B2 (ja) 2017-04-12
AU2013280779A1 (en) 2014-11-27
DOP2014000286A (es) 2015-01-31
MX2014015952A (es) 2015-07-17
CY1118830T1 (el) 2018-01-10
DK2867218T3 (en) 2017-05-01
PL2867218T3 (pl) 2017-07-31
GT201400289A (es) 2015-05-28
TN2014000500A1 (en) 2016-03-30
EP2867218B1 (en) 2017-02-22
IN2014MN02356A (ar) 2015-08-14
CL2014003537A1 (es) 2015-04-24
TW201410665A (zh) 2014-03-16
SG11201408629QA (en) 2015-01-29
US8933098B2 (en) 2015-01-13
RS55756B1 (sr) 2017-07-31
ZA201408631B (en) 2017-04-26
CR20140554A (es) 2015-02-04

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