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Organic Low-Molecular-Weight Compounds And Preparation Thereof
(AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts
(AREA)
Abstract
A stereospecific method for accomplishing the below reaction:results in the compound of formula 2 having the same stereochemistry at both carbon 1 and carbon 3 as that in the compound of formula 1. Thus, if carbon 3 is in the R-configuration in the compound of formula 1, then carbon 3 will be in the R-configuration in the compound of resulting formula 2. In the above process, R1 is C1-C6 alkyl that can be straight-chain or branched. The process functions using a fluorinated alcohol having a pKa less than about 9, in the presence of a palladium catalyst. The compounds of formula 1, as well as novel intermediates in this process, are useful in manufacturing vitamin D analogs.
JO2000146A1999-08-232000-08-20Process for the preparation of vitmain d analogues
JO2194B1
(en)
Derivatives of cyclohexanecarboxylic acid, a mixture of isomers or separate isomers and physiologically suitable salts and a pharmaceutical composition with activity inhibiting enzyme complex of glucose-6-phosphatase