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IT1403518B1 - Dispositivo microfluidico per la manipolazione di particelle - Google Patents

Dispositivo microfluidico per la manipolazione di particelle

Info

Publication number
IT1403518B1
IT1403518B1 ITBO2010A000755A ITBO20100755A IT1403518B1 IT 1403518 B1 IT1403518 B1 IT 1403518B1 IT BO2010A000755 A ITBO2010A000755 A IT BO2010A000755A IT BO20100755 A ITBO20100755 A IT BO20100755A IT 1403518 B1 IT1403518 B1 IT 1403518B1
Authority
IT
Italy
Prior art keywords
microfluid device
particle handling
handling
particle
microfluid
Prior art date
Application number
ITBO2010A000755A
Other languages
English (en)
Inventor
Nicolo' Manaresi
Gianni Medoro
Original Assignee
Silicon Biosystems Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ITBO2010A000755A priority Critical patent/IT1403518B1/it
Application filed by Silicon Biosystems Spa filed Critical Silicon Biosystems Spa
Priority to ES11815589.4T priority patent/ES2586404T3/es
Priority to US13/994,158 priority patent/US9950322B2/en
Priority to CN201180062566.1A priority patent/CN103282127B/zh
Priority to JP2013545619A priority patent/JP6084575B2/ja
Priority to EP11815589.4A priority patent/EP2654964B1/en
Priority to CA2845690A priority patent/CA2845690C/en
Priority to DK11815589.4T priority patent/DK2654964T3/da
Priority to PCT/IB2011/055920 priority patent/WO2012085884A1/en
Publication of ITBO20100755A1 publication Critical patent/ITBO20100755A1/it
Application granted granted Critical
Publication of IT1403518B1 publication Critical patent/IT1403518B1/it
Priority to JP2016202629A priority patent/JP2017077557A/ja

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C5/00—Separating dispersed particles from liquids by electrostatic effect
    • B03C5/02—Separators
    • B03C5/022—Non-uniform field separators
    • B03C5/026—Non-uniform field separators using open-gradient differential dielectric separation, i.e. using electrodes of special shapes for non-uniform field creation, e.g. Fluid Integrated Circuit [FIC]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/04—Exchange or ejection of cartridges, containers or reservoirs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0652—Sorting or classification of particles or molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/141—Preventing contamination, tampering
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/02—Identification, exchange or storage of information
    • B01L2300/023—Sending and receiving of information, e.g. using bluetooth
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/02—Identification, exchange or storage of information
    • B01L2300/024—Storing results with means integrated into the container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0883—Serpentine channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G01N27/44791—Microapparatus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Engineering & Computer Science (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micromachines (AREA)
ITBO2010A000755A 2010-12-22 2010-12-22 Dispositivo microfluidico per la manipolazione di particelle IT1403518B1 (it)

Priority Applications (10)

Application Number Priority Date Filing Date Title
ITBO2010A000755A IT1403518B1 (it) 2010-12-22 2010-12-22 Dispositivo microfluidico per la manipolazione di particelle
US13/994,158 US9950322B2 (en) 2010-12-22 2011-12-22 Microfluidic device for the manipulation of particles
CN201180062566.1A CN103282127B (zh) 2010-12-22 2011-12-22 用于处理颗粒的微流体装置
JP2013545619A JP6084575B2 (ja) 2010-12-22 2011-12-22 粒子を操作するためのマイクロ流体デバイス
ES11815589.4T ES2586404T3 (es) 2010-12-22 2011-12-22 Dispositivo de microfluidos para manipular partículas
EP11815589.4A EP2654964B1 (en) 2010-12-22 2011-12-22 Microfluidic device for manipulating particles
CA2845690A CA2845690C (en) 2010-12-22 2011-12-22 Microfluidic device for manipulating particles
DK11815589.4T DK2654964T3 (da) 2010-12-22 2011-12-22 Mikrofluidindretning til manipulering af partikler
PCT/IB2011/055920 WO2012085884A1 (en) 2010-12-22 2011-12-22 Microfluidic device for the manipulation of particles
JP2016202629A JP2017077557A (ja) 2010-12-22 2016-10-14 粒子を操作するためのマイクロ流体デバイス

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITBO2010A000755A IT1403518B1 (it) 2010-12-22 2010-12-22 Dispositivo microfluidico per la manipolazione di particelle

Publications (2)

Publication Number Publication Date
ITBO20100755A1 ITBO20100755A1 (it) 2012-06-23
IT1403518B1 true IT1403518B1 (it) 2013-10-31

Family

ID=43736787

Family Applications (1)

Application Number Title Priority Date Filing Date
ITBO2010A000755A IT1403518B1 (it) 2010-12-22 2010-12-22 Dispositivo microfluidico per la manipolazione di particelle

Country Status (9)

Country Link
US (1) US9950322B2 (it)
EP (1) EP2654964B1 (it)
JP (2) JP6084575B2 (it)
CN (1) CN103282127B (it)
CA (1) CA2845690C (it)
DK (1) DK2654964T3 (it)
ES (1) ES2586404T3 (it)
IT (1) IT1403518B1 (it)
WO (1) WO2012085884A1 (it)

Families Citing this family (7)

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Publication number Priority date Publication date Assignee Title
IT201600104601A1 (it) 2016-10-18 2018-04-18 Menarini Silicon Biosystems Spa Sistema microfluidico
SG11201903247VA (en) 2016-10-18 2019-05-30 Menarini Silicon Biosystems Spa Microfluidic device, microfluidic system and method for the isolation of particles
IT201700105948A1 (it) 2017-09-21 2019-03-21 Menarini Silicon Biosystems Spa Metodo e sistema microfluidico per il recupero di particelle
IT201700105911A1 (it) 2017-09-21 2019-03-21 Menarini Silicon Biosystems Spa Metodo ed apparato per la riduzione del volume di un campione
EP3628071B1 (en) 2018-07-27 2022-07-06 Zepto Life Technology, LLC System and method for sample preparation in gmr-based detection of biomarkers
IT201900002777A1 (it) 2019-02-26 2020-08-26 Menarini Silicon Biosystems Spa Metodo e sistema microfluidico per l'isolamento di particelle
IT202100013715A1 (it) 2021-05-26 2022-11-26 Menarini Silicon Biosystems Spa Metodo e sistema microfluidico per l'isolamento di particelle

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EP2654964B1 (en) 2016-05-11
EP2654964A1 (en) 2013-10-30
ITBO20100755A1 (it) 2012-06-23
US9950322B2 (en) 2018-04-24
DK2654964T3 (da) 2016-08-22
JP2014508026A (ja) 2014-04-03
CA2845690C (en) 2019-11-05
CN103282127B (zh) 2016-02-24
US20130343966A1 (en) 2013-12-26
JP6084575B2 (ja) 2017-02-22
WO2012085884A1 (en) 2012-06-28
CN103282127A (zh) 2013-09-04
JP2017077557A (ja) 2017-04-27
CA2845690A1 (en) 2012-06-28
WO2012085884A8 (en) 2012-09-07

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