IT1149329B - Derivati di tiazolidinilalchilen piperazina dotati di attivita' ansiolitica e procedimento di preparazione - Google Patents

Derivati di tiazolidinilalchilen piperazina dotati di attivita' ansiolitica e procedimento di preparazione

Info

Publication number: IT1149329B
Authority: IT; Italy
Prior art keywords: thiazolidinylalkylen; preparation procedure; piperazine derivatives; anxiolytic activity; derivatives equipped
Prior art date: 1981-08-03

Application number

IT48909/82A

Other languages

English (en)

Other versions

IT8248909A0 (it

Inventor

Davis L Temple

Richard E Yeager

Original Assignee

Bristol Myers Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-08-03

Filing date

1982-07-29

Publication date

1986-12-03

1982-07-29 Application filed by Bristol Myers Co filed Critical Bristol Myers Co

1982-07-29 Publication of IT8248909A0 publication Critical patent/IT8248909A0/it

1986-12-03 Application granted granted Critical

1986-12-03 Publication of IT1149329B publication Critical patent/IT1149329B/it

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/34—Oxygen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Psychiatry (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)

IT48909/82A 1981-08-03 1982-07-29 Derivati di tiazolidinilalchilen piperazina dotati di attivita' ansiolitica e procedimento di preparazione IT1149329B (it)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/289,352 US4367335A (en)	1981-08-03	1981-08-03	Thiazolidinylalkylene piperazine derivatives

Publications (2)

Publication Number	Publication Date
IT8248909A0 IT8248909A0 (it)	1982-07-29
IT1149329B true IT1149329B (it)	1986-12-03

Family

ID=23111164

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT48909/82A IT1149329B (it)	1981-08-03	1982-07-29	Derivati di tiazolidinilalchilen piperazina dotati di attivita' ansiolitica e procedimento di preparazione

Country Status (28)

Country	Link
US (1)	US4367335A (it)
JP (2)	JPS5826877A (it)
KR (1)	KR880001478B1 (it)
AT (1)	AT381705B (it)
AU (1)	AU560655B2 (it)
BE (1)	BE894022A (it)
CA (1)	CA1172636A (it)
CH (1)	CH652398A5 (it)
DE (1)	DE3228990A1 (it)
DK (1)	DK162991C (it)
ES (1)	ES8307800A1 (it)
FI (1)	FI76793C (it)
FR (1)	FR2510572B1 (it)
GB (1)	GB2106104B (it)
GR (1)	GR76172B (it)
HU (1)	HU191187B (it)
IE (1)	IE53641B1 (it)
IL (1)	IL66434A0 (it)
IT (1)	IT1149329B (it)
LU (1)	LU84316A1 (it)
NL (1)	NL8203034A (it)
NZ (1)	NZ201159A (it)
OA (1)	OA07172A (it)
PH (1)	PH18220A (it)
PT (1)	PT75366B (it)
SE (1)	SE452320B (it)
YU (1)	YU44074B (it)
ZA (1)	ZA825479B (it)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4456756A (en) *	1981-08-03	1984-06-26	Mead Johnson & Company	Spirothiazolidinyl piperazine derivatives
US4452799A (en) *	1981-12-23	1984-06-05	Mead Johnson & Company	Benzisothiazole and benzisoxazole piperazine derivatives
US4620006A (en) *	1982-08-11	1986-10-28	Eastman Kodak Company	Acid salts of 1-(cyanoalkyl)-4-guanylpiperazines
US4619930A (en) *	1985-01-16	1986-10-28	Bristol-Myers Company	Antipsychotic cyclic imide derivatives of 2-(4-butylpiperazin-1-yl)pyridines, compositions and use
CA1278792C (en) *	1985-05-06	1991-01-08	Joseph P. Yevich	Antipsychotic fused-ring pyridinylpiperazine derivatives
US4677104A (en) *	1985-05-06	1987-06-30	Bristol-Myers Company	Antipsychotic fused-ring pyridinylpiperazine derivatives
US4675403A (en) *	1985-10-16	1987-06-23	American Home Products Corporation	3-Aminoalkyl derivatives of 5,5-disubstituted hydantoins with psychotropic activity
US4784998A (en) *	1987-04-06	1988-11-15	Bristol-Myers Company	1,3,4-oxadiazole pyschotropic compounds
US5801186A (en) *	1987-11-20	1998-09-01	Hoechst Marion Roussel, Inc.	3- 4-(1-substituted-4-piperazinyl)butyl!-4-thiazolidinone and related compounds
US4880930A (en) *	1987-11-30	1989-11-14	New James S	Psychotropic acyclic amide derivatives
US5116970A (en) *	1988-02-18	1992-05-26	New James S	Psychotropic heterobicycloalkylpiperazine derivatives: 2. fused pyridazinones
US5001130A (en) *	1988-02-18	1991-03-19	Bristol-Myers Company	Psychotropic heterobicycloalkylpiperazine derivatives
US4780466A (en) *	1988-03-17	1988-10-25	Hoechst-Roussel Pharmaceuticals, Inc.	Arylpiperazinylalkoxy derivatives of cyclic imides
FR2642759B1 (fr) *	1989-02-09	1991-05-17	Laboratorios Esteve Sa	Derives de pyrimidyl-piperazinyl-alkyl azoles avec activite anxiolytique et/ou tranquillisante
JPH0415948U (it) *	1990-05-31	1992-02-10
US5130315A (en) *	1991-01-10	1992-07-14	Raymond R. Wittekind	1-piperazinyl-2-butenes and -2-butynes
US5194436A (en) *	1991-01-10	1993-03-16	Hoechst-Roussel Pharmaceuticals Inc.	1-piperazinyl-2-butenes and -2-butynes
US20040077605A1 (en) *	2001-06-20	2004-04-22	Salvati Mark E.	Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
WO2003093236A1 (en) *	2002-05-02	2003-11-13	Euro-Celtique, S.A.	1-(pyrid-2-yl)-piperazine compounds as metabotropic glutamate receptor inhibitor
WO2006013445A2 (en) *	2004-07-28	2006-02-09	Ranbaxy Laboratories Limited	Thiazolidinedione derivatives as alpha adrenergic receptor antagonists

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2672460A (en) *	1952-06-24	1954-03-16	American Cyanamid Co	Disubstituted piperazines and methods of preparing the same
US2748125A (en) *	1954-04-26	1956-05-29	American Cyanamid Co	1-substituted-4-sulfamylpiperazine and method of preparing the same
NL125835C (it) *	1960-05-24
FR1435004A (fr) *	1965-02-04	1966-04-15	Sobio Lab	Dérivés de thiazolidine-dione-2, 4- et procédé de préparation
US3398151A (en) *	1966-02-01	1968-08-20	Mead Johnson & Co	Azaspirodecanediones and azaspiroundecanediones
DE1695410A1 (de) *	1967-04-20	1971-04-08	Merck Patent Gmbh	Verfahren zur Herstellung von 1-(Thiazolyl-5-alkyl)-4-(pyridyl-2)-piperazinen
US3635976A (en) *	1967-12-20	1972-01-18	Pennwalt Corp	1 - heterocyclic alkyl-1 2 3 4-tetrahydroquinazolinones and analgesic intermediates thereof
US3822266A (en) *	1968-12-24	1974-07-02	Hoffmann La Roche	(3-(1-piperazinyl)-2-hydroxy-propoxy)acetanilides
BE759371A (fr) *	1969-11-24	1971-05-24	Bristol Myers Co	Azaspirodecanediones heterocycliques et procedes pour leur preparation
IT1052119B (it) *	1972-10-16	1981-06-20	Sigma Tau Ind Farmaceuti	Derivati del triazolinone e procedimento per la loro preparazione
US3976776A (en) *	1972-12-06	1976-08-24	Mead Johnson & Company	Tranquilizer process employing N-(heteroarcyclic)piperazinylalkylazaspiroalkanediones
US4017622A (en) *	1972-12-18	1977-04-12	Dainippon Pharmaceutical Co., Ltd.	Piperazine derivatives
DE2263211A1 (de) *	1972-12-23	1974-07-04	Boehringer Sohn Ingelheim	Neue arylpiperazine und verfahren zu ihrer herstellung
US3919230A (en) *	1974-02-07	1975-11-11	Smithkline Corp	{62 -Naphthylmethyl piperazinyl derivatives
FR2285883A1 (fr) *	1974-09-30	1976-04-23	Cerm Cent Europ Rech Mauvernay	Nouveaux composes chimiques a activite bronchospasmolytique et antitussive, et procede pour leur obtention
US3940398A (en) *	1975-01-23	1976-02-24	E. R. Squibb & Sons, Inc.	2-[[4-(Azine or diazine or triazine)-1-piperazinyl]alkyl]-1H-benz[de]isoquinoline-1,3(2H)-diones
US4026894A (en) *	1975-10-14	1977-05-31	Abbott Laboratories	Antihypertensive agents
US4060615A (en) *	1976-02-18	1977-11-29	Mead Johnson & Company	2-Piperazinyl-6,7-dimethoxyquinazolines
US4001237A (en) *	1976-02-18	1977-01-04	Bristol-Myers Company	Oxazole, isoxazole, thiazole and isothiazole amides
GB1518559A (en) *	1976-04-12	1978-07-19	Science Union & Cie	Naphthyl derivatives processes for their preparation an pharmaceutical compositions containing them
US4078063A (en) *	1976-09-24	1978-03-07	Merck & Co., Inc.	Piperazinylpyridines
US4101548A (en) *	1977-02-22	1978-07-18	Bristol-Myers Company	1,2,3-Thiadiazole amides
HU173380B (hu) *	1977-02-25	1979-04-28	Richter Gedeon Vegyeszet	Sposob poluchenija novogo proizvodnogo piridil-piperazina i kislo-additivnykh solejj
DE2727469A1 (de) *	1977-06-18	1978-12-21	Hoechst Ag	Neue hexahydropyrimidine, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten
US4138561A (en) *	1977-09-30	1979-02-06	Bristol-Myers Company	Cyanocarboxamidines and quinazoline process
EP0002978B1 (fr) *	1977-12-29	1982-10-06	Synthelabo	Dérivés de thiazolidinedione-2,4, leur préparation et leur application en thérapeutique
FR2418798A1 (fr) *	1978-03-03	1979-09-28	Science Union & Cie	Nouvelles piperazines disubstituees, leurs procedes de preparation et les compositions pharmaceutiques les renfermant
US4182763A (en) *	1978-05-22	1980-01-08	Mead Johnson & Company	Buspirone anti-anxiety method
FI791926A (fi) *	1978-06-20	1979-12-21	Synthelabo	Fenylpiperazinderivat
US4161595A (en) *	1978-10-02	1979-07-17	Bristol-Myers Company	Levulinic acid salt

1981
- 1981-08-03 US US06/289,352 patent/US4367335A/en not_active Expired - Fee Related
1982
- 1982-07-05 NZ NZ201159A patent/NZ201159A/en unknown
- 1982-07-06 AU AU85663/82A patent/AU560655B2/en not_active Ceased
- 1982-07-13 GR GR68741A patent/GR76172B/el unknown
- 1982-07-20 YU YU1586/82A patent/YU44074B/xx unknown
- 1982-07-23 ES ES514264A patent/ES8307800A1/es not_active Expired
- 1982-07-28 FR FR8213177A patent/FR2510572B1/fr not_active Expired
- 1982-07-29 ZA ZA825479A patent/ZA825479B/xx unknown
- 1982-07-29 NL NL8203034A patent/NL8203034A/nl not_active Application Discontinuation
- 1982-07-29 IT IT48909/82A patent/IT1149329B/it active
- 1982-07-30 DK DK343682A patent/DK162991C/da active
- 1982-07-30 PH PH27654A patent/PH18220A/en unknown
- 1982-07-30 CA CA000408450A patent/CA1172636A/en not_active Expired
- 1982-07-30 IE IE1852/82A patent/IE53641B1/en not_active IP Right Cessation
- 1982-07-30 FI FI822667A patent/FI76793C/fi not_active IP Right Cessation
- 1982-08-01 IL IL66434A patent/IL66434A0/xx not_active IP Right Cessation
- 1982-08-02 CH CH4661/82A patent/CH652398A5/de not_active IP Right Cessation
- 1982-08-02 PT PT75366A patent/PT75366B/pt not_active IP Right Cessation
- 1982-08-02 SE SE8204550A patent/SE452320B/sv not_active IP Right Cessation
- 1982-08-02 HU HU822485A patent/HU191187B/hu not_active IP Right Cessation
- 1982-08-02 GB GB08222212A patent/GB2106104B/en not_active Expired
- 1982-08-03 KR KR8203482A patent/KR880001478B1/ko active
- 1982-08-03 AT AT0299482A patent/AT381705B/de not_active IP Right Cessation
- 1982-08-03 JP JP57134808A patent/JPS5826877A/ja active Granted
- 1982-08-03 LU LU84316A patent/LU84316A1/fr unknown
- 1982-08-03 BE BE0/208748A patent/BE894022A/fr not_active IP Right Cessation
- 1982-08-03 OA OA57765A patent/OA07172A/xx unknown
- 1982-08-03 DE DE19823228990 patent/DE3228990A1/de not_active Withdrawn
1990
- 1990-03-29 JP JP2079032A patent/JPH02270821A/ja active Granted

Also Published As

Publication number	Publication date
JPH0371410B2 (it)	1991-11-13
BE894022A (fr)	1983-02-03
GR76172B (it)	1984-08-03
SE452320B (sv)	1987-11-23
FI822667L (fi)	1983-02-04
DK343682A (da)	1983-02-04
IE53641B1 (en)	1989-01-04
SE8204550D0 (sv)	1982-08-02
ATA299482A (de)	1986-04-15
YU158682A (en)	1985-04-30
ZA825479B (en)	1983-04-27
ES514264A0 (es)	1983-08-01
JPH02270821A (ja)	1990-11-05
HU191187B (en)	1987-01-28
DK162991B (da)	1992-01-06
PT75366A (en)	1982-09-01
FR2510572B1 (fr)	1986-05-09
AU560655B2 (en)	1987-04-16
JPH0235754B2 (it)	1990-08-13
NL8203034A (nl)	1983-03-01
ES8307800A1 (es)	1983-08-01
FR2510572A1 (fr)	1983-02-04
GB2106104B (en)	1985-05-09
OA07172A (fr)	1984-04-30
GB2106104A (en)	1983-04-07
FI822667A0 (fi)	1982-07-30
DE3228990A1 (de)	1983-03-03
NZ201159A (en)	1985-10-11
KR880001478B1 (ko)	1988-08-13
PT75366B (en)	1985-11-20
SE8204550L (sv)	1983-02-04
KR840001167A (ko)	1984-03-28
CH652398A5 (de)	1985-11-15
JPS5826877A (ja)	1983-02-17
LU84316A1 (fr)	1983-06-07
IE821852L (en)	1983-02-03
DK162991C (da)	1992-06-01
FI76793B (fi)	1988-08-31
US4367335A (en)	1983-01-04
CA1172636A (en)	1984-08-14
AU8566382A (en)	1983-02-10
PH18220A (en)	1985-04-30
YU44074B (en)	1990-02-28
IT8248909A0 (it)	1982-07-29
IL66434A0 (en)	1982-12-31
AT381705B (de)	1986-11-25
FI76793C (fi)	1988-12-12

Publication	Publication Date	Title
IT1149329B (it)	1986-12-03	Derivati di tiazolidinilalchilen piperazina dotati di attivita' ansiolitica e procedimento di preparazione
DE3677206D1 (de)	1991-02-28	D-luciferin-derivate und deren verwendung.
FR2521561B1 (fr)	1986-10-10	Derives de benzisothiazole et benzisoxale piperazine
ES512259A0 (es)	1983-02-16	"procedimiento para la preparacion de nuevos derivados piperidinicos piperacinicos y homopiperacinicos".
IT1143960B (it)	1986-10-29	Nuovi derivati piperidinici dotati di attivita' anti-istaminica antiallergia e broncodilatatrice e procedimento per la preparazione
IT8519512A0 (it)	1985-02-14	Derivati naturali ad attivita'farmacologica
MX9203090A (es)	1992-07-01	Derivados de finilisopropilamina y su preparacion.
DK254488A (da)	1988-06-24	Azaindol- og indolizinderivater
IT1196133B (it)	1988-11-10	Derivati furanici con attivita' antiulcera
IT8148162A0 (it)	1981-03-31	Derivati di piperazina dotati di attivita' farmacologica
DE3588103D1 (de)	1996-05-30	5-Fluorouracil-Derivate
DK574085A (da)	1986-06-13	Alkoxymethylether- og alkoxymethylesterderivater
IT1149026B (it)	1986-12-03	Derivati di spirotiazolidinil piperazina dotati di attivita' antipsicotica, e procedimento per la loro preparazione
ES519880A0 (es)	1984-06-16	Procedimiento de preparacion de nuevos derivados de piperazina y de homopiperazina.
IT1212902B (it)	1989-11-30	Derivati etendiamminici e guanidinici dotati di attivita' farmacologica
IT8249771A0 (it)	1982-12-29	Derivati di cicloesanone aventi attivita' diserbante, e procedimento per la loro preparazione
IT8521236A0 (it)	1985-06-21	Amminoacil derivati di 4(5)-imidazolidinoni ad attivita
IT1149073B (it)	1986-12-03	Derivati di 4-piridilpiridazinone dotati di attivita' antiinfiammatoria ed analgesica
IT1148145B (it)	1986-11-26	Derivati azaspiroalcandionici dotati di attivita'psicotropica e procedimento per la loro preparazione
IT8449192A1 (it)	1986-05-20	Derivati butanolici dotati di attivita' antiaritmica e procedimento di preparazione
IT1143941B (it)	1986-10-29	Derivati alfa-alogenometilamminici dotati di attivita' farmacologica e procedimento per la loro preparazione
ES511366A0 (es)	1983-07-01	"un procedimiento para la preparacion de derivados de piridina y pirrolidina".
IT8519226A0 (it)	1985-01-25	Derivati tiazolidinici ad attivita' mucoregolatrice.
IT1150706B (it)	1986-12-17	Derivati di eterociclici azotati dotati di attivita' fitoregolatrice
IT8521460A0 (it)	1985-07-05	Procedimento di preparazione di derivati eterociclici.