Nothing Special   »   [go: up one dir, main page]

IL104559A0 - N-sulfonyl-2-oxoindole derivatives,their preparation and pharmaceutical compositions containing them - Google Patents

N-sulfonyl-2-oxoindole derivatives,their preparation and pharmaceutical compositions containing them

Info

Publication number
IL104559A0
IL104559A0 IL104559A IL10455993A IL104559A0 IL 104559 A0 IL104559 A0 IL 104559A0 IL 104559 A IL104559 A IL 104559A IL 10455993 A IL10455993 A IL 10455993A IL 104559 A0 IL104559 A0 IL 104559A0
Authority
IL
Israel
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
sulfonyl
derivatives
Prior art date
Application number
IL104559A
Original Assignee
Sanofi Elf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Elf filed Critical Sanofi Elf
Publication of IL104559A0 publication Critical patent/IL104559A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/90—Benzo [c, d] indoles; Hydrogenated benzo [c, d] indoles
    • C07D209/92—Naphthostyrils
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/96—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

N-sulphonyl-2-oxoindole derivatives of formula (I), and any salts thereof, preparation thereof and pharmaceutical compositions containing said derivatives. These compounds have an affinity for vasopressin and/or ocytocin receptors.
IL104559A 1992-01-30 1993-01-29 N-sulfonyl-2-oxoindole derivatives,their preparation and pharmaceutical compositions containing them IL104559A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9201034A FR2686878B1 (en) 1992-01-30 1992-01-30 DERIVATIVES OF N-SULFONYL OXO-2 INDOLE, THEIR PREPARATION, THE PHARMACEUTICAL COMPOSITIONS CONTAINING SAME.

Publications (1)

Publication Number Publication Date
IL104559A0 true IL104559A0 (en) 1993-05-13

Family

ID=9426168

Family Applications (1)

Application Number Title Priority Date Filing Date
IL104559A IL104559A0 (en) 1992-01-30 1993-01-29 N-sulfonyl-2-oxoindole derivatives,their preparation and pharmaceutical compositions containing them

Country Status (20)

Country Link
EP (1) EP0581939B1 (en)
JP (1) JPH06507182A (en)
AT (1) ATE180773T1 (en)
AU (1) AU662960B2 (en)
BR (1) BR9303993A (en)
CA (1) CA2107348A1 (en)
CZ (1) CZ203793A3 (en)
DE (1) DE69325130D1 (en)
FI (2) FI934274A0 (en)
FR (1) FR2686878B1 (en)
HU (1) HUT68642A (en)
IL (1) IL104559A0 (en)
MX (1) MX9300498A (en)
NO (1) NO180538C (en)
NZ (1) NZ249158A (en)
RU (1) RU2135469C1 (en)
SK (1) SK105393A3 (en)
TW (1) TW239126B (en)
WO (1) WO1993015051A1 (en)
ZA (1) ZA93649B (en)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5849780A (en) * 1992-01-30 1998-12-15 Sanofi 1-benzenesulfonyl-1-1,3-dihydroindol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present
FR2708605A1 (en) * 1993-07-30 1995-02-10 Sanofi Sa N-sulfonylindol-2-one derivatives, their preparation, pharmaceutical compositions containing them.
US5686624A (en) * 1992-01-30 1997-11-11 Sanofi 1-benzenesulfonyl-1,3-dihydro-indol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present
FR2708606B1 (en) * 1993-07-30 1995-10-27 Sanofi Sa N-phenylalkylindol-2-one derivatives, their preparation, pharmaceutical compositions containing them.
FR2708608B1 (en) * 1993-07-30 1995-10-27 Sanofi Sa N-sulfonylbenzimidazolone derivatives, their preparation, pharmaceutical compositions containing them.
FR2714378B1 (en) * 1993-12-24 1996-03-15 Sanofi Sa Indol-2-one derivatives substituted in 3 with a nitrogen group, their preparation, pharmaceutical compositions containing them.
FR2722190B1 (en) * 1994-07-05 1996-10-04 Sanofi Sa 1-BENZYL-1,3-DIHYDRO-2H-BENZIMIDAZOL-2-ONE DERIVATIVES, THEIR PREPARATION, THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
AU5772196A (en) * 1995-05-19 1996-11-29 Chiroscience Limited 3,4-disubstituted-phenylsulphonamides and their therapeutic use
FR2740136B1 (en) * 1995-10-24 1998-01-09 Sanofi Sa INDOLIN-2-ONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US5756497A (en) * 1996-03-01 1998-05-26 Merck & Co., Inc. Tocolytic oxytocin receptor antagonists
EP1202994B1 (en) 1999-07-21 2004-04-14 AstraZeneca AB New compounds
GB9918684D0 (en) 1999-08-09 1999-10-13 Novartis Ag Organic compounds
WO2002070478A1 (en) 2001-03-06 2002-09-12 Astrazeneca Ab Indolone derivatives having vascular-damaging activity
DE10222034A1 (en) * 2002-05-17 2003-11-27 Bayer Ag New 2-benzenesulfonyl-3,4-dihydro-2(1H)-isoquinoline derivatives, are PPAR-delta activators useful e.g. for treating coronary heart disease, dyslipidemia or restenosis
US20050070718A1 (en) 2003-09-30 2005-03-31 Abbott Gmbh & Co. Kg Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them
US8580842B2 (en) 2003-09-30 2013-11-12 Abbott Gmbh & Co. Kg Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them
US7414052B2 (en) 2004-03-30 2008-08-19 Wyeth Phenylaminopropanol derivatives and methods of their use
US7517899B2 (en) 2004-03-30 2009-04-14 Wyeth Phenylaminopropanol derivatives and methods of their use
CA2593044A1 (en) * 2004-12-31 2006-07-13 Abbott Gmbh & Co. Kg Substituted oxindole derivatives, medicaments containing said derivatives and use thereof
US8030499B2 (en) 2005-01-28 2011-10-04 Taisho Pharmaceutical Co., Ltd. 1,3-dihydro-2H-indole-2-one compound and pyrrolidine-2-one compound fused with aromatic heterocycle
DE102005014936A1 (en) 2005-03-24 2006-12-14 Abbott Gmbh & Co. Kg New substituted oxindole derivatives are vasopressin receptor binders useful to treat e.g. diabetes insipidus, enuresis nocturna, incontinence, hypertonia, heart failure, myocardial infarction, coronary spasm and renal disorders
DE102005014904A1 (en) * 2005-03-26 2007-02-01 Abbott Gmbh & Co. Kg New substituted oxindole derivatives are vasopressin receptor binders useful to treat e.g. diabetes insipidus, enuresis nocturna, incontinence, hypertonia, heart failure, myocardial infarction, coronary spasm and renal disorders
EP1861392A2 (en) 2005-03-24 2007-12-05 Abbott GmbH & Co. KG Substituted oxindol derivatives, drugs containing said derivatives and the use thereof
DE102005015957A1 (en) * 2005-03-31 2006-10-05 Abbott Gmbh & Co. Kg New substituted oxindole derivatives are vasopressin receptor binders useful to treat e.g. diabetes insipidus, enuresis nocturna, incontinence, hypertonia, heart failure, myocardial infarction, coronary spasm and renal disorders
AR056968A1 (en) 2005-04-11 2007-11-07 Xenon Pharmaceuticals Inc ESPIRO-OXINDOL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS
MY145694A (en) 2005-04-11 2012-03-30 Xenon Pharmaceuticals Inc Spiroheterocyclic compounds and their uses as therapeutic agents
JP2009507800A (en) 2005-09-09 2009-02-26 ユーロ−セルティーク エス．エイ． Fused and spirocyclic compounds and uses thereof
WO2007063123A1 (en) 2005-12-02 2007-06-07 Abbott Gmbh & Co. Kg Substituted oxindol-derivatives, medicaments containing said derivatives and use thereof
JP5437070B2 (en) 2006-08-26 2014-03-12 アボット ゲーエムベーハー ウント カンパニー カーゲー Substituted benzimidazolone derivatives, drugs containing the same and uses thereof
DE102006040915A1 (en) 2006-08-26 2008-03-20 Abbott Gmbh & Co. Kg New oxindole derivatives useful for treating vasopressin- or oxytocin-dependent diseases
US7825110B2 (en) * 2006-09-22 2010-11-02 Janssen Pharmaceutica Nv Substituted spiroheterocycles
AU2007299822A1 (en) * 2006-09-22 2008-03-27 Janssen Pharmaceutica N.V. Spiro benzazepines as vasopressin antagonists
AR063280A1 (en) 2006-10-12 2009-01-21 Xenon Pharmaceuticals Inc USE OF ESPIRO-OXINDOL COMPOUNDS AS THERAPEUTIC AGENTS
FR2909668B1 (en) * 2006-12-12 2009-01-23 Sanofi Aventis Sa 5-ALKYLOXY-INDOLIN-2-ONE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATIONS
US20080167286A1 (en) 2006-12-12 2008-07-10 Abbott Laboratories Pharmaceutical compositions and their methods of use
US8486979B2 (en) 2006-12-12 2013-07-16 Abbvie Inc. 1,2,4 oxadiazole compounds and methods of use thereof
UY30846A1 (en) 2006-12-30 2008-07-31 Abbott Gmbh & Amp OXINDOL DERIVATIVES REPLACED, MEDICINES THAT UNDERSTAND AND USE THEMSELVES
WO2010009775A1 (en) 2007-12-07 2010-01-28 Abbott Gmbh & Co. Kg Carbamate-substituted oxindole derivatives and use thereof for the treatment of vasopressin-dependent diseases
ES2455197T3 (en) 2007-12-07 2014-04-14 Abbvie Deutschland Gmbh & Co Kg 5,6-disubstituted oxindole derivatives and their use for the preparation of a medicine for the treatment of vasopressin-dependent diseases
CA2707667C (en) 2007-12-07 2016-02-23 Abbott Gmbh & Co. Kg Amidomethyl-substituted oxindole derivatives and the use thereof for the treatment of vasopressin-dependent illnesses
JP5595926B2 (en) 2007-12-07 2014-09-24 アボット ゲーエムベーハー ウント カンパニー カーゲー 5-Halogen-substituted oxindole derivatives and their use in the treatment of vasopressin-dependent diseases
BRPI0821431A8 (en) 2007-12-27 2015-09-22 Abbott Gmbh & Co Kg substituted oxindole derivatives and their use for the treatment of vasopressin-dependent diseases.
FR2927625B1 (en) 2008-02-19 2010-03-12 Sanofi Aventis NOVEL 3-AMINOALKYL-1,3-DIHYDRO-2H-INDOL-2-ONE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE
FR2930249B1 (en) * 2008-04-21 2010-05-14 Sanofi Aventis NOVEL 3-AMINOALKYL-1,3-DIHYDRO-2H-INDOL-2-ONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF
US8101647B2 (en) 2008-10-17 2012-01-24 Xenon Pharmaceuticals Inc. Spiro-oxindole compounds and their use as therapeutic agents
EP2350090B1 (en) 2008-10-17 2015-06-03 Xenon Pharmaceuticals Inc. Spiro-oxindole compounds and their use as therapeutic agents
WO2010138600A2 (en) 2009-05-29 2010-12-02 Abbott Laboratories Pharmaceutical compositions for the treatment of pain
AR077252A1 (en) 2009-06-29 2011-08-10 Xenon Pharmaceuticals Inc ESPIROOXINDOL COMPOUND ENANTIOMERS AND THEIR USES AS THERAPEUTIC AGENTS
AU2010306768B2 (en) 2009-10-14 2016-08-04 Xenon Pharmaceuticals Inc. Synthetic methods for spiro-oxindole compounds
CA2788440A1 (en) 2010-02-26 2011-09-01 Xenon Pharmaceuticals Inc. Pharmaceutical compositions of spiro-oxindole compound for topical administration and their use as therapeutic agents
EP2881391A1 (en) 2013-12-05 2015-06-10 Bayer Pharma Aktiengesellschaft Spiroindoline carbocycle derivatives and pharmaceutical compositions thereof
TW201636017A (en) 2015-02-05 2016-10-16 梯瓦製藥國際有限責任公司 Methods of treating postherpetic neuralgia with a topical formulation of a spiro-oxindole compound
KR20180101565A (en) * 2016-01-20 2018-09-12 케모센트릭스, 인크. 2-oxynol compound

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2540057A (en) 1947-07-02 1951-01-30 Gen Aniline & Film Corp Aromatic and heterocyclic diazosulfones
US3838167A (en) * 1972-08-01 1974-09-24 Lilly Co Eli Process for preparing indoles
DK167393B1 (en) 1985-12-30 1993-10-25 Roussel Uclaf 1-SULPHONYL-2-OXO-PYRROLIDINE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEREOF
US4863437A (en) * 1986-03-20 1989-09-05 Clarke Ellis W Means for fluid administration
US4803217A (en) * 1986-12-24 1989-02-07 Merck & Co., Inc. Hapalindolinone compounds as vassopressin antagonists
EP0303418A3 (en) * 1987-08-11 1990-11-07 Smithkline Beecham Laboratoires Pharmaceutiques Substituted indolones, useful in the treatment of heart or asthmatic diseases
EP0429685B1 (en) * 1989-07-25 1997-10-29 Taiho Pharmaceutical Company, Limited Oxoindole derivative

Also Published As

Publication number Publication date
EP0581939B1 (en) 1999-06-02
NO180538B (en) 1997-01-27
FI934274A (en) 1993-09-29
SK105393A3 (en) 1994-08-10
DE69325130D1 (en) 1999-07-08
FI980341A0 (en) 1998-02-13
AU3504393A (en) 1993-09-01
WO1993015051A1 (en) 1993-08-05
NO933482L (en) 1993-11-29
NO180538C (en) 1997-05-07
CZ203793A3 (en) 1994-04-13
ATE180773T1 (en) 1999-06-15
MX9300498A (en) 1994-07-29
FI934274A0 (en) 1993-09-29
AU662960B2 (en) 1995-09-21
BR9303993A (en) 1994-08-02
RU2135469C1 (en) 1999-08-27
NO933482D0 (en) 1993-09-29
TW239126B (en) 1995-01-21
ZA93649B (en) 1993-09-02
CA2107348A1 (en) 1993-07-31
FI980341A (en) 1998-02-13
EP0581939A1 (en) 1994-02-09
NZ249158A (en) 1996-02-27
FR2686878B1 (en) 1995-06-30
HUT68642A (en) 1995-07-28
HU9302762D0 (en) 1993-12-28
FR2686878A1 (en) 1993-08-06
JPH06507182A (en) 1994-08-11

Similar Documents

Publication Publication Date Title
TW239126B (en)
ES8704906A1 (en) Benzodiazepine derivatives and pharmaceutical compositions containing them.
IL124537A0 (en) Naphthyl-substituted benzimidazole derivatives and pharmaceutical compositions containing the same
NZ244021A (en) Benzylthiazolidinedione derivatives, preparation and pharmaceutical compositions thereof
GR3018182T3 (en) Derivatives of amidinophenylalanine, procedure for their preparation, their utilisation and anticoagulant compositions comprising them.
AU2001235596A1 (en) Novel 1,3-dihydro-2h-indol-2-one derivatives, preparation method and pharmaceutical compositions containing them
ES8704946A1 (en) Triazolobenzodiazepines and pharmaceutical compositions containing them.
IL92358A0 (en) Diaryl compounds,their preparation and pharmaceutical compositions containing them
WO1992014696A3 (en) SUBSTITUTED α-AMINOALDEHYDES AND DERIVATIVES
IL96636A0 (en) Piperidine derivatives and pharmaceutical compositions containing them
IL113365A (en) 5-Heterocyclo-1,5-benzodiazepine derivatives their preparation and pharmaceutical compositions containing them
KR960703863A (en) New Bis-naphthalimides for the Treatment of Cancer
IL99898A0 (en) 7-acyl-3-substituted carbamoyloxy cephem compounds,their preparation and antibacterial compositions containing them
TW371661B (en) Novel intermediates and their use to prepare N,N'-bridged bisindolylmaleimides
MY115795A (en) Substituted benzenesulfonylureas and -thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds, and medicaments containing them
ATE282608T1 (en) QUINOXALINDIONES
TW261605B (en)
ES8706147A1 (en) Benzodiazepine derivatives and pharmaceutical compositions containing them.
ES2049186A1 (en) Benzofuranylimidazole derivatives and therapeutical compositions containing the same
AU567498B2 (en) 5-phenyl-1h-2,3-dihydro-1,4-benzodiazepine derivatives.
JO1519B1 (en) Novel compounds (Novel deravatives of Benzimidazoles active as anti-ulcer agents).
IT1252568B (en) Arylether-substituted pyrimidine derivatives having A II antagonist activity