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IE39537B1 - Substituted 16,17,18,19,20-pentanor-prostaglandins - Google Patents

Substituted 16,17,18,19,20-pentanor-prostaglandins

Info

Publication number
IE39537B1
IE39537B1 IE2002/73A IE200273A IE39537B1 IE 39537 B1 IE39537 B1 IE 39537B1 IE 2002/73 A IE2002/73 A IE 2002/73A IE 200273 A IE200273 A IE 200273A IE 39537 B1 IE39537 B1 IE 39537B1
Authority
IE
Ireland
Prior art keywords
phenoxy
oxo
trans
pentanor
prostaglandins
Prior art date
Application number
IE2002/73A
Other versions
IE39537L (en
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Priority to IE55973A priority Critical patent/IE39538B1/en
Priority to IE560/77A priority patent/IE39539B1/en
Publication of IE39537L publication Critical patent/IE39537L/en
Publication of IE39537B1 publication Critical patent/IE39537B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C07F9/5407—Acyclic saturated phosphonium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1456512 Silylated oxaprostaglandins PFIZER Inc 7 Nov 1973 [8 Nov 1972] 51758/73 Heading C3S [Also in Division C2] Dimethylisopropylsilyl 9 - oxo - 11α,15α - bis- (dimethylisopropylsilyloxy) - 16 - phenoxy - 17, 18,19,20 - tetra - nor - trans - 13 - prostenoate is prepared by hydrogenating dimethylisopropylsilyl 9 - oxo - 11α,15α - bis - (dimethylisopropylsilyloxy) - 16 - phenoxy - 17,18,19,20 - tetranorcis - S, trans - 13 - prostadienoate, obtained by reacting 9 - oxo - 11α,15α - dihydroxy - 16- phenoxy - 17,18,19,20 - tetranor - cis - S, trans- 13-prostadienoic acid with dimethylisopropylchlorosilane. [GB1456512A]
IE2002/73A 1972-11-08 1973-11-07 Substituted 16,17,18,19,20-pentanor-prostaglandins IE39537B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IE55973A IE39538B1 (en) 1972-11-08 1973-11-07 Derivatives of cyclopentanecetic acid
IE560/77A IE39539B1 (en) 1972-11-08 1973-11-07 Substituted dialkyl-2-oxopropylphonates

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US30481372A 1972-11-08 1972-11-08

Publications (2)

Publication Number Publication Date
IE39537L IE39537L (en) 1974-05-08
IE39537B1 true IE39537B1 (en) 1978-11-08

Family

ID=23178133

Family Applications (1)

Application Number Title Priority Date Filing Date
IE2002/73A IE39537B1 (en) 1972-11-08 1973-11-07 Substituted 16,17,18,19,20-pentanor-prostaglandins

Country Status (29)

Country Link
JP (3) JPS5416491B2 (en)
AR (3) AR200585A1 (en)
AT (3) AT367034B (en)
AU (1) AU470375B2 (en)
BE (1) BE806995A (en)
CA (3) CA1085831A (en)
CH (1) CH597176A5 (en)
CS (3) CS182794B2 (en)
DD (4) DD118856A5 (en)
DE (1) DE2355540C2 (en)
DK (1) DK144247C (en)
ES (3) ES420325A1 (en)
FI (1) FI60389C (en)
FR (3) FR2205335B1 (en)
GB (3) GB1456514A (en)
HK (3) HK27979A (en)
HU (3) HU173507B (en)
IE (1) IE39537B1 (en)
IL (1) IL43589A (en)
IN (1) IN139384B (en)
KE (3) KE2931A (en)
MY (3) MY7900243A (en)
NL (1) NL164273C (en)
NO (3) NO147836C (en)
PH (3) PH13272A (en)
SE (4) SE448992B (en)
SU (4) SU584766A3 (en)
YU (3) YU39715B (en)
ZA (1) ZA738554B (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3929862A (en) * 1974-01-08 1975-12-30 Upjohn Co Substituted tolylesters of PGF{HD 2{B {60
GB1506817A (en) * 1975-03-31 1978-04-12 Upjohn Co Prostaglandins
US3986764A (en) * 1975-03-31 1976-10-19 Gte Automatic Electric Laboratories Incorporated Panel for supporting a pair of elongated mating connectors and selectively locking them together
ES449162A1 (en) * 1975-06-23 1977-12-16 Syntex Inc 16-Phenoxy and 16-substituted phenoxy-prostatrienoic acid derivatives
GB1516414A (en) * 1975-08-22 1978-07-05 Ici Ltd Prostane derivatives
SE7809008L (en) * 1977-12-12 1979-06-13 Upjohn Co USE OF PROSTAGLAND TYPE AMIDES TO CONTROL OR REGULATE THE REPRODUCTION CYCLE IN INDIVIDUALS OF MAMMALS
DK523378A (en) * 1978-01-16 1979-07-17 Pfizer PROCEDURE FOR THE PREPARATION OF N- (TETRAZOL-5-YL) PROSTAGLANDIN CARBOXAMIDES OR SALTS THEREOF
NZ503738A (en) * 1997-09-09 2001-05-25 Procter & Gamble Aromatic C16-20-substituted tetrahydro prostaglandin F analogues useful as FP agonists
NZ513825A (en) 1999-03-05 2001-09-28 Procter & Gamble C 16 unsaturated FP-selective prostaglandins analogs
US6894175B1 (en) 1999-08-04 2005-05-17 The Procter & Gamble Company 2-Decarboxy-2-phosphinico prostaglandin derivatives and methods for their preparation and use
US20020172693A1 (en) 2000-03-31 2002-11-21 Delong Michell Anthony Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US20020037914A1 (en) 2000-03-31 2002-03-28 Delong Mitchell Anthony Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins
US20020013294A1 (en) 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
JP2002329615A (en) * 2001-05-02 2002-11-15 Ohira Denshi Kk Toroidal coil
US6476064B1 (en) * 2001-06-13 2002-11-05 Allergan, Inc. Cyclopentane heptan(ene) acyl sulfonamide, 2-alkyl or 2-arylalkyl, or 2-heteroarylalkenyl derivatives as therapeutic agents
WO2006047466A2 (en) 2004-10-21 2006-05-04 Duke University Ophthamological drugs
US8623918B2 (en) 2008-10-29 2014-01-07 Novaer Holdings, Inc. Amino acid salts of prostaglandins
US8722739B2 (en) 2008-10-29 2014-05-13 Novaer Holdings, Inc. Amino acid salts of prostaglandins

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1324737A (en) * 1970-11-02 1973-07-25 Upjohn Co Prostaglandins and the preparation thereof
IE37602B1 (en) * 1971-05-11 1977-08-31 Ici Ltd Cyclopentane derivatives

Also Published As

Publication number Publication date
ZA738554B (en) 1974-09-25
CS182793B2 (en) 1978-05-31
AR202931A1 (en) 1975-07-31
HK28179A (en) 1979-05-11
CA1088931A (en) 1980-11-04
SE448992B (en) 1987-03-30
DE2355540C2 (en) 1982-11-18
PH13110A (en) 1979-11-28
ES433046A1 (en) 1977-06-16
DD109212A5 (en) 1974-10-20
CA1088930A (en) 1980-11-04
NL7315263A (en) 1974-05-10
YU36975B (en) 1984-08-31
FR2279729B1 (en) 1978-04-28
YU39715B (en) 1985-04-30
PH13325A (en) 1980-03-13
JPS5416491B2 (en) 1979-06-22
NO147836B (en) 1983-03-14
GB1456514A (en) 1976-11-24
AU470375B2 (en) 1976-03-11
KE2931A (en) 1979-03-30
PH13272A (en) 1980-02-27
NO148998C (en) 1984-01-25
CH597176A5 (en) 1978-03-31
HK28079A (en) 1979-05-11
DK144247C (en) 1982-07-12
DK144247B (en) 1982-01-25
MY7900243A (en) 1979-12-31
NO750535L (en) 1974-05-09
SU893130A3 (en) 1981-12-23
IL43589A (en) 1980-01-31
BE806995A (en) 1974-05-07
CA1085831A (en) 1980-09-16
AR199966A1 (en) 1974-10-08
FI60389C (en) 1982-01-11
MY7900245A (en) 1979-12-31
FI60389B (en) 1981-09-30
ATA544676A (en) 1979-04-15
MY7900246A (en) 1979-12-31
GB1456512A (en) 1976-11-24
DD119411A5 (en) 1976-04-20
SU584766A3 (en) 1977-12-15
FR2205335B1 (en) 1978-07-13
SE431756B (en) 1984-02-27
GB1456513A (en) 1976-11-24
NL164273C (en) 1980-12-15
FR2283146A1 (en) 1976-03-26
ATA936973A (en) 1981-10-15
HU172703B (en) 1978-11-28
ATA544576A (en) 1980-06-15
AT367034B (en) 1982-05-25
JPS4993342A (en) 1974-09-05
ES433047A1 (en) 1976-11-01
DE2355540A1 (en) 1974-05-22
NO149139B (en) 1983-11-14
FR2279729A1 (en) 1976-02-20
YU270780A (en) 1982-06-18
YU288073A (en) 1982-02-28
AT353285B (en) 1979-11-12
SU745362A3 (en) 1980-06-30
SE7700718L (en) 1977-01-24
HU173507B (en) 1979-05-28
HU171819B (en) 1978-03-28
SE7700717L (en) 1977-01-24
NO147836C (en) 1983-06-22
FR2205335A1 (en) 1974-05-31
JPS5257147A (en) 1977-05-11
JPS5253841A (en) 1977-04-30
KE2930A (en) 1979-03-30
NO148998B (en) 1983-10-17
HK27979A (en) 1979-05-11
AR200585A1 (en) 1974-11-22
ES420325A1 (en) 1976-04-16
IE39537L (en) 1974-05-08
CS182791B2 (en) 1978-05-31
SE7700716L (en) 1977-01-24
YU270680A (en) 1983-04-27
AU6224773A (en) 1975-05-08
IN139384B (en) 1976-06-12
IL43589A0 (en) 1974-03-14
YU37316B (en) 1984-08-31
AT360672B (en) 1981-01-26
DD117233A5 (en) 1976-01-05
FR2283146B1 (en) 1981-06-19
CS182794B2 (en) 1978-05-31
SE445111B (en) 1986-06-02
SE436278B (en) 1984-11-26
NO149139C (en) 1984-02-29
DE2365322B2 (en) 1977-02-24
KE2932A (en) 1979-03-30
DD118856A5 (en) 1976-03-20
DE2365322A1 (en) 1974-11-07
SU667141A3 (en) 1979-06-05
NO743493L (en) 1974-05-09

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