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HUP0202062A2 - Eljárás maszkírozott ízű és azonnali hatóanyag-leadású bevont szemcsék előállítására - Google Patents

Eljárás maszkírozott ízű és azonnali hatóanyag-leadású bevont szemcsék előállítására

Info

Publication number
HUP0202062A2
HUP0202062A2 HU0202062A HUP0202062A HUP0202062A2 HU P0202062 A2 HUP0202062 A2 HU P0202062A2 HU 0202062 A HU0202062 A HU 0202062A HU P0202062 A HUP0202062 A HU P0202062A HU P0202062 A2 HUP0202062 A2 HU P0202062A2
Authority
HU
Hungary
Prior art keywords
granules
masked taste
active particle
instant release
making granules
Prior art date
Application number
HU0202062A
Other languages
English (en)
Inventor
Etienne Bruna
Charles Chauveau
Nouredine Nouri
Jean-Marc Zuccarelli
Original Assignee
Ethypharm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ethypharm filed Critical Ethypharm
Publication of HUP0202062A2 publication Critical patent/HUP0202062A2/hu
Publication of HUP0202062A3 publication Critical patent/HUP0202062A3/hu
Publication of HU229568B1 publication Critical patent/HU229568B1/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y10T428/2998—Coated including synthetic resin or polymer

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Seasonings (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Formation And Processing Of Food Products (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A találmány maszkírozott ízű és azonnali hatóanyagleadású bevontszemcsékre és azok előállítására alkalmas eljárásra vonatkozik, amelyszerint legalább a hatóanyagból és egy a szemcse szétesését elősegítőanyagból álló por komponenseit először szárazon összekeverik; a kapottport ezután a segédanyagok olyan keveréke jelenlétében granulálják,amely legalább egy a részecskéket szemcsévé összekötni képeskötőanyagot tartalmaz, és nem tartalmaz a membrán szétesését elősegítőanyagot; a képződött szemcséket legalább egy bevonószert és egy amembrán szétesését elősegítő anyagot tartalmazó szuszpenzióvalpermetezéssel bevonják; végül a kapott bevont szemcséket szárítják. Ó
HU0202062A 1999-07-08 2000-06-30 Eljárás maszkírozott ízû és azonnali hatóanyag-leadású bevont szemcsék elõállítására HU229568B1 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9909047A FR2795962B1 (fr) 1999-07-08 1999-07-08 Procede de fabrication de granules enrobes a gout masque et liberation immediate du principe actif
PCT/FR2000/001855 WO2001003672A1 (fr) 1999-07-08 2000-06-30 Procede de fabrication de granules enrobes a gout masque et liberation immediate du principe actif

Publications (3)

Publication Number Publication Date
HUP0202062A2 true HUP0202062A2 (hu) 2002-12-28
HUP0202062A3 HUP0202062A3 (en) 2004-05-28
HU229568B1 HU229568B1 (hu) 2014-02-28

Family

ID=9548029

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0202062A HU229568B1 (hu) 1999-07-08 2000-06-30 Eljárás maszkírozott ízû és azonnali hatóanyag-leadású bevont szemcsék elõállítására

Country Status (31)

Country Link
US (1) US6660382B2 (hu)
EP (1) EP1194125B1 (hu)
JP (1) JP4749639B2 (hu)
KR (1) KR100767928B1 (hu)
CN (1) CN1220485C (hu)
AT (1) ATE360412T1 (hu)
AU (1) AU760006B2 (hu)
BG (1) BG65615B1 (hu)
BR (1) BR0012250A (hu)
CA (1) CA2375600C (hu)
CY (1) CY1107695T1 (hu)
CZ (1) CZ300154B6 (hu)
DE (1) DE60034565T2 (hu)
DK (1) DK1194125T3 (hu)
DZ (1) DZ3257A1 (hu)
EA (1) EA003161B1 (hu)
ES (1) ES2284507T3 (hu)
FR (1) FR2795962B1 (hu)
HK (1) HK1049119B (hu)
HU (1) HU229568B1 (hu)
IL (2) IL147212A0 (hu)
MA (1) MA25426A1 (hu)
MX (1) MXPA01013354A (hu)
NO (1) NO331256B1 (hu)
NZ (1) NZ516594A (hu)
PL (1) PL201782B1 (hu)
PT (1) PT1194125E (hu)
SK (1) SK287322B6 (hu)
TR (1) TR200200013T2 (hu)
WO (1) WO2001003672A1 (hu)
ZA (1) ZA200200344B (hu)

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Also Published As

Publication number Publication date
US20020098227A1 (en) 2002-07-25
DZ3257A1 (fr) 2001-01-18
KR20020015062A (ko) 2002-02-27
IL147212A (en) 2007-05-15
PL201782B1 (pl) 2009-05-29
ES2284507T3 (es) 2007-11-16
PL354257A1 (en) 2003-12-29
MA25426A1 (fr) 2002-04-01
FR2795962B1 (fr) 2003-05-09
DE60034565D1 (de) 2007-06-06
ZA200200344B (en) 2003-03-26
AU760006B2 (en) 2003-05-08
SK19392001A3 (sk) 2002-04-04
KR100767928B1 (ko) 2007-10-17
EP1194125A1 (fr) 2002-04-10
BG65615B1 (bg) 2009-03-31
NO20016308D0 (no) 2001-12-21
EA003161B1 (ru) 2003-02-27
CY1107695T1 (el) 2013-04-18
DE60034565T2 (de) 2007-12-27
JP4749639B2 (ja) 2011-08-17
NZ516594A (en) 2003-11-28
ATE360412T1 (de) 2007-05-15
CZ300154B6 (cs) 2009-02-25
EP1194125B1 (fr) 2007-04-25
HU229568B1 (hu) 2014-02-28
PT1194125E (pt) 2007-07-03
TR200200013T2 (tr) 2002-06-21
HK1049119A1 (en) 2003-05-02
CA2375600A1 (fr) 2001-01-18
US6660382B2 (en) 2003-12-09
HK1049119B (zh) 2006-05-12
SK287322B6 (sk) 2010-07-07
CA2375600C (fr) 2011-05-10
DK1194125T3 (da) 2007-07-30
EA200200136A1 (ru) 2002-06-27
AU5993600A (en) 2001-01-30
IL147212A0 (en) 2002-08-14
BR0012250A (pt) 2002-03-26
FR2795962A1 (fr) 2001-01-12
WO2001003672A1 (fr) 2001-01-18
CZ200218A3 (cs) 2002-04-17
CN1373658A (zh) 2002-10-09
JP2003504324A (ja) 2003-02-04
CN1220485C (zh) 2005-09-28
NO20016308L (no) 2001-12-21
BG106398A (en) 2002-09-30
NO331256B1 (no) 2011-11-07
MXPA01013354A (es) 2002-07-09
HUP0202062A3 (en) 2004-05-28

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