HRP20040855B1 - Micronized crystalline tiotropium bromide - Google Patents

Micronized crystalline tiotropium bromide

Info

Publication number: HRP20040855B1
Authority: HR; Croatia
Prior art keywords: tiotropium bromide; crystalline tiotropium; micronized crystalline; micronized; bromide
Prior art date: 2002-03-20

Application number

Other languages

English (en)

Inventor

Helmut Bender

Hagen Graebner

Konrad Schindler

Michael Trunk

Michael Walz

Original Assignee

Boehringer Ingelheim Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-03-20

Filing date

2004-09-17

Publication date

2012-11-30

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27797948&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20040855(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2004-09-17 Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma

2005-06-30 Publication of HRP20040855A2 publication Critical patent/HRP20040855A2/hr

2012-11-30 Publication of HRP20040855B1 publication Critical patent/HRP20040855B1/xx

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Catalysts (AREA)
Medicinal Preparation (AREA)
Silicates, Zeolites, And Molecular Sieves (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Glass Compositions (AREA)
Hybrid Cells (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

HR20040855 2002-03-20 2004-09-17 Micronized crystalline tiotropium bromide HRP20040855B1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10212264A DE10212264A1 (de)	2002-03-20	2002-03-20	Kristallines Mikronisat, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels
PCT/EP2003/002422 WO2003078429A1 (de)	2002-03-20	2003-03-10	Kristallines mikronisat des tiotropiumbromids

Publications (2)

Publication Number	Publication Date
HRP20040855A2 HRP20040855A2 (en)	2005-06-30
HRP20040855B1 true HRP20040855B1 (en)	2012-11-30

Family

ID=27797948

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20040855 HRP20040855B1 (en)	2002-03-20	2004-09-17	Micronized crystalline tiotropium bromide

Country Status (37)

Country	Link
EP (3)	EP1487832B9 (ru)
JP (1)	JP4331619B2 (ru)
KR (2)	KR101021430B1 (ru)
CN (2)	CN101220025A (ru)
AR (1)	AR039017A1 (ru)
AT (1)	ATE369365T1 (ru)
AU (1)	AU2003212327B2 (ru)
BR (1)	BRPI0308513B8 (ru)
CA (1)	CA2479652C (ru)
CO (1)	CO5611105A2 (ru)
CY (2)	CY1106923T1 (ru)
DE (2)	DE10212264A1 (ru)
DK (2)	DK1487832T4 (ru)
EA (1)	EA007064B1 (ru)
EC (1)	ECSP045310A (ru)
ES (2)	ES2615460T3 (ru)
HK (1)	HK1078871A1 (ru)
HR (1)	HRP20040855B1 (ru)
HU (1)	HUE031876T2 (ru)
IL (2)	IL163841A0 (ru)
LT (1)	LT1785422T (ru)
ME (1)	ME02764B (ru)
MX (1)	MXPA04009056A (ru)
MY (1)	MY139720A (ru)
NO (2)	NO346754B1 (ru)
NZ (1)	NZ535808A (ru)
PE (1)	PE20030838A1 (ru)
PL (1)	PL220730B1 (ru)
PT (2)	PT1785422T (ru)
RS (1)	RS57551B1 (ru)
SA (1)	SA03240098B1 (ru)
SI (1)	SI1487832T2 (ru)
TW (1)	TWI345975B (ru)
UA (1)	UA78295C2 (ru)
UY (1)	UY27725A1 (ru)
WO (1)	WO2003078429A1 (ru)
ZA (1)	ZA200405636B (ru)

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US7056916B2 (en)	2002-11-15	2006-06-06	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Medicaments for the treatment of chronic obstructive pulmonary disease
DK1682543T3 (da)	2003-11-03	2010-12-13	Boehringer Ingelheim Int	Fremgangsmåde til fremstilling af nye tiotropiumsalte
DE502004010885D1 (de)	2003-11-03	2010-04-22	Boehringer Ingelheim Pharma	Verfahren zur herstellung von tiotropiumsalzen
US7220742B2 (en)	2004-05-14	2007-05-22	Boehringer Ingelheim International Gmbh	Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments
DE102004024451A1 (de)	2004-05-14	2005-12-22	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Pulverformulierungen für die Inhalation, die Enantiomerenreine Betaagonisten enthalten
CA2606552A1 (en) *	2005-05-02	2006-11-09	Boehringer Ingelheim International Gmbh	Crystalline forms of tiotropium bromide
BRPI0609295A2 (pt)	2005-05-02	2010-03-23	Boehringer Ingelheim Int	formas cristalinas de brometo de tiotràpio, composiÇço farmacÊutica, uso e mÉtodo para preparar as mesmas
PL1917253T3 (pl)	2005-08-15	2015-06-30	Boehringer Ingelheim Int	Sposób wytwarzania betamimetyków
US20070086957A1 (en) *	2005-10-10	2007-04-19	Thierry Bouyssou	Combination of medicaments for the treatment of respiratory diseases
DE102005059602A1 (de) *	2005-12-14	2007-06-21	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Verfahren zur Mikronisierung
JP5086267B2 (ja)	2005-12-19	2012-11-28	シコールインコーポレイティド	臭化チオトロピウムの新規な形態およびそれを製造する方法
US9108962B2 (en)	2005-12-19	2015-08-18	Sicor, Inc.	Forms of tiotropium bromide and processes for preparation thereof
CN100999521B (zh) *	2006-01-13	2010-12-08	江苏正大天晴药业股份有限公司	结晶性抗胆碱药噻托溴铵
GB0716026D0 (en)	2007-08-16	2007-09-26	Norton Healthcare Ltd	An inhalable medicament
WO2011093815A2 (en) *	2010-01-29	2011-08-04	Mahmut Bilgic	Pharmaceutical compositions comprising formoterol and mometasone
GB201200525D0 (en)	2011-12-19	2012-02-29	Teva Branded Pharmaceutical Prod R & D Inc	An inhalable medicament
PT106142B (pt) *	2012-02-10	2014-07-18	Hovione Farmaci Ncia S A	Processo para a preparação de brometo de tiotrópio
WO2014007768A1 (en)	2012-07-05	2014-01-09	Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi	Dry powder inhaler compositions comprising long acting muscorinic antagonists
EP2705838A1 (en) *	2012-09-06	2014-03-12	Xspray Microparticles Ab	Tiotropium preparations
WO2014042605A1 (en) *	2012-09-11	2014-03-20	Mahmut Bilgic	New tiotropium bromide crystalline form
US10034866B2 (en)	2014-06-19	2018-07-31	Teva Branded Pharmaceutical Products R&D, Inc.	Inhalable medicament comprising tiotropium
SI3191081T1 (sl)	2014-09-09	2020-07-31	Vectura Limited	Formulacija, ki vsebuje glikopirolat, postopek in naprava
WO2017068119A1 (en) *	2015-10-23	2017-04-27	Arven Ilac Sanayi Ve Ticaret A.S.	Blister for tiotropium bromide inhalable formulation
BR112018008083A2 (pt) *	2015-10-23	2018-10-23	Arven Ilac Sanayi Ve Ticaret As	blister para formulação inalável de brometo de tiotrópio
CN115737610B (zh) *	2021-12-13	2024-02-27	苏州欧米尼医药有限公司	一种噻托溴铵吸入粉雾剂及其活性成分的气流粉碎方法

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DE102005059602A1 (de)	2005-12-14	2007-06-21	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Verfahren zur Mikronisierung
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2002
- 2002-03-20 DE DE10212264A patent/DE10212264A1/de not_active Withdrawn
2003
- 2003-03-10 KR KR1020047014831A patent/KR101021430B1/ko active IP Right Grant
- 2003-03-10 ME MEP-2008-467A patent/ME02764B/me unknown
- 2003-03-10 AT AT03708206T patent/ATE369365T1/de active
- 2003-03-10 ES ES07102206.5T patent/ES2615460T3/es not_active Expired - Lifetime
- 2003-03-10 ES ES03708206.2T patent/ES2291619T5/es not_active Expired - Lifetime
- 2003-03-10 BR BRPI0308513A patent/BRPI0308513B8/pt not_active IP Right Cessation
- 2003-03-10 DE DE50307883T patent/DE50307883D1/de not_active Expired - Lifetime
- 2003-03-10 PL PL371799A patent/PL220730B1/pl unknown
- 2003-03-10 RS RS82604A patent/RS57551B1/sr unknown
- 2003-03-10 MX MXPA04009056A patent/MXPA04009056A/es active IP Right Grant
- 2003-03-10 EP EP03708206.2A patent/EP1487832B9/de not_active Expired - Lifetime
- 2003-03-10 PT PT71022065T patent/PT1785422T/pt unknown
- 2003-03-10 AU AU2003212327A patent/AU2003212327B2/en not_active Expired
- 2003-03-10 CN CNA2008100024354A patent/CN101220025A/zh active Pending
- 2003-03-10 IL IL16384103A patent/IL163841A0/xx unknown
- 2003-03-10 DK DK03708206.2T patent/DK1487832T4/en active
- 2003-03-10 LT LTEP07102206.5T patent/LT1785422T/lt unknown
- 2003-03-10 KR KR1020107028543A patent/KR101094091B1/ko active IP Right Grant
- 2003-03-10 EP EP16159836.2A patent/EP3053921A1/de not_active Withdrawn
- 2003-03-10 CN CNB038065169A patent/CN100368410C/zh not_active Ceased
- 2003-03-10 SI SI200330973T patent/SI1487832T2/sl unknown
- 2003-03-10 HU HUE07102206A patent/HUE031876T2/en unknown
- 2003-03-10 PT PT03708206T patent/PT1487832E/pt unknown
- 2003-03-10 DK DK07102206.5T patent/DK1785422T3/en active
- 2003-03-10 EP EP07102206.5A patent/EP1785422B1/de not_active Expired - Lifetime
- 2003-03-10 WO PCT/EP2003/002422 patent/WO2003078429A1/de active IP Right Grant
- 2003-03-10 EA EA200401142A patent/EA007064B1/ru not_active IP Right Cessation
- 2003-03-10 JP JP2003576434A patent/JP4331619B2/ja not_active Expired - Lifetime
- 2003-03-10 NZ NZ535808A patent/NZ535808A/en not_active IP Right Cessation
- 2003-03-10 CA CA2479652A patent/CA2479652C/en not_active Expired - Fee Related
- 2003-03-10 NO NO20190824A patent/NO346754B1/no not_active IP Right Cessation
- 2003-03-18 MY MYPI20030947A patent/MY139720A/en unknown
- 2003-03-18 PE PE2003000268A patent/PE20030838A1/es not_active Application Discontinuation
- 2003-03-18 UY UY27725A patent/UY27725A1/es not_active Application Discontinuation
- 2003-03-18 TW TW092105919A patent/TWI345975B/zh not_active IP Right Cessation
- 2003-03-19 AR ARP030100957A patent/AR039017A1/es not_active Suspension/Interruption
- 2003-04-29 SA SA03240098A patent/SA03240098B1/ar unknown
- 2003-10-03 UA UA20041008391A patent/UA78295C2/uk unknown
2004
- 2004-07-15 ZA ZA2004/05636A patent/ZA200405636B/en unknown
- 2004-08-31 IL IL163841A patent/IL163841A/en not_active IP Right Cessation
- 2004-09-17 HR HR20040855 patent/HRP20040855B1/xx not_active IP Right Cessation
- 2004-09-23 EC EC2004005310A patent/ECSP045310A/es unknown
- 2004-09-23 NO NO20044003A patent/NO344427B1/no not_active IP Right Cessation
- 2004-10-15 CO CO04104123A patent/CO5611105A2/es not_active Application Discontinuation
2005
- 2005-12-01 HK HK05110949A patent/HK1078871A1/xx not_active IP Right Cessation
2007
- 2007-10-10 CY CY20071101300T patent/CY1106923T1/el unknown
2017
- 2017-02-13 CY CY20171100194T patent/CY1118855T1/el unknown

Also Published As

Publication number	Publication date
WO2003078429A1 (de)	2003-09-25
EP1487832B9 (de)	2019-01-23
BR0308513A (pt)	2005-01-04
CA2479652C (en)	2012-07-10
NO344427B1 (no)	2019-12-02
EP1487832A1 (de)	2004-12-22
RS57551B1 (sr)	2018-10-31
KR101094091B1 (ko)	2011-12-15
PL371799A1 (en)	2005-06-27
IL163841A0 (en)	2005-12-18
PT1785422T (pt)	2017-02-17
JP2005526776A (ja)	2005-09-08
EP1785422A8 (de)	2010-06-23
TWI345975B (en)	2011-08-01
CA2479652A1 (en)	2003-09-25
MEP46708A (en)	2011-02-10
LT1785422T (lt)	2017-02-10
ES2291619T5 (es)	2018-12-07
NZ535808A (en)	2005-09-30
DE10212264A1 (de)	2003-10-02
DE50307883D1 (de)	2007-09-20
DK1487832T3 (da)	2007-11-05
EA200401142A1 (ru)	2005-04-28
DK1487832T4 (en)	2018-12-10
ES2615460T3 (es)	2017-06-07
EA007064B1 (ru)	2006-06-30
KR20100135983A (ko)	2010-12-27
IL163841A (en)	2015-10-29
CO5611105A2 (es)	2006-02-28
AU2003212327A1 (en)	2003-09-29
BRPI0308513B1 (pt)	2016-04-19
SI1487832T2 (sl)	2018-11-30
PE20030838A1 (es)	2003-11-21
EP3053921A1 (de)	2016-08-10
HUE031876T2 (en)	2017-08-28
ZA200405636B (en)	2006-01-25
DK1785422T3 (en)	2017-02-27
HRP20040855A2 (en)	2005-06-30
UY27725A1 (es)	2003-10-31
NO346754B1 (no)	2022-12-12
AR039017A1 (es)	2005-02-02
NO20044003L (no)	2004-10-14
PL220730B1 (pl)	2015-12-31
BRPI0308513B8 (pt)	2021-05-25
MXPA04009056A (es)	2005-01-25
CN1642952A (zh)	2005-07-20
NO20190824A1 (no)	2004-10-14
ECSP045310A (es)	2004-10-26
MY139720A (en)	2009-10-30
ES2291619T3 (es)	2008-03-01
PT1487832E (pt)	2007-08-27
KR20050008662A (ko)	2005-01-21
CY1106923T1 (el)	2012-09-26
CY1118855T1 (el)	2018-01-10
CN101220025A (zh)	2008-07-16
JP4331619B2 (ja)	2009-09-16
UA78295C2 (en)	2007-03-15
EP1785422B1 (de)	2016-11-16
TW200305421A (en)	2003-11-01
EP1487832B2 (de)	2018-08-29
AU2003212327B2 (en)	2009-02-05
HK1078871A1 (en)	2006-03-24
KR101021430B1 (ko)	2011-03-15
ME02764B (me)	2011-05-10
EP1487832B1 (de)	2007-08-08
ATE369365T1 (de)	2007-08-15
SI1487832T1 (sl)	2007-12-31
EP1785422A1 (de)	2007-05-16
CN100368410C (zh)	2008-02-13
SA03240098B1 (ar)	2008-03-24

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EP1652853A4 (en)	2009-12-02	CRYSTALLINE COMPOUNDS OF 6-N-PYRIDYLMETHYLAMINOINDOLOCARBAZOLE
IL169772A0 (en)	2007-07-04	Crystalline modification
TW578759U (en)	2004-03-01	Structure for fast assembled universal frame main spindle set
TW549115U (en)	2003-08-21	A baseball bracket
GB0303097D0 (en)	2003-03-19	Crystalline therapeutic agent
GB0321309D0 (en)	2003-10-15	Crystalline therapeutic agent
SI1472256T1 (sl)	2006-04-30	Piperidinovi derivati
TW568060U (en)	2003-12-21	Arbor structure
HU2405U (en)	2002-11-28	Combined feeder unit
TW538858U (en)	2003-06-21	Improved structure for screwdriver

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