Nothing Special   »   [go: up one dir, main page]

HK1212882A1 - 血液因子的監測分析及其用途 - Google Patents

血液因子的監測分析及其用途

Info

Publication number
HK1212882A1
HK1212882A1 HK15111993.7A HK15111993A HK1212882A1 HK 1212882 A1 HK1212882 A1 HK 1212882A1 HK 15111993 A HK15111993 A HK 15111993A HK 1212882 A1 HK1212882 A1 HK 1212882A1
Authority
HK
Hong Kong
Prior art keywords
blood factor
factor monitoring
monitoring assay
assay
blood
Prior art date
Application number
HK15111993.7A
Other languages
English (en)
Inventor
Sommer Jurg
Original Assignee
Biogen Idec Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Idec Inc filed Critical Biogen Idec Inc
Publication of HK1212882A1 publication Critical patent/HK1212882A1/zh

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21022—Coagulation factor IXa (3.4.21.22)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/745—Assays involving non-enzymic blood coagulation factors
    • G01N2333/755—Factors VIII, e.g. factor VIII C [AHF], factor VIII Ag [VWF]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96433—Serine endopeptidases (3.4.21)
    • G01N2333/96441—Serine endopeptidases (3.4.21) with definite EC number
    • G01N2333/9645—Factor IX (3.4.21.22)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/22—Haematology
    • G01N2800/224—Haemostasis or coagulation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK15111993.7A 2012-07-25 2015-12-03 血液因子的監測分析及其用途 HK1212882A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261675713P 2012-07-25 2012-07-25
PCT/US2013/052101 WO2014018777A2 (en) 2012-07-25 2013-07-25 Blood factor monitoring assay and uses thereof

Publications (1)

Publication Number Publication Date
HK1212882A1 true HK1212882A1 (zh) 2016-06-24

Family

ID=49997977

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15111993.7A HK1212882A1 (zh) 2012-07-25 2015-12-03 血液因子的監測分析及其用途

Country Status (4)

Country Link
US (3) US10001495B2 (zh)
EP (2) EP3970738A1 (zh)
HK (1) HK1212882A1 (zh)
WO (1) WO2014018777A2 (zh)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3970738A1 (en) 2012-07-25 2022-03-23 Bioverativ Therapeutics Inc. Blood factor monitoring assay and uses thereof
US9745087B2 (en) 2013-01-04 2017-08-29 Tama Plastic Industry Method and apparatus for securing baled items
EP3080612B1 (en) * 2013-12-09 2021-12-01 DSM IP Assets B.V. Identification of anticoagulants in a sample
US11181534B2 (en) * 2014-04-04 2021-11-23 Bloodworks Routine laboratory and point-of-care (POC) testing for hemostasis
KR102415992B1 (ko) 2016-04-15 2022-07-04 다케다 야쿠힌 고교 가부시키가이샤 약물동역학 약물 투약 요법을 제공하는 방법 및 장치
CN107759697B (zh) 2016-08-19 2023-03-24 安源医药科技（上海）有限公司 制备融合蛋白的方法
CN106279437B (zh) * 2016-08-19 2017-10-31 安源医药科技（上海）有限公司 高糖基化人凝血因子viii融合蛋白及其制备方法与用途
US10896749B2 (en) 2017-01-27 2021-01-19 Shire Human Genetic Therapies, Inc. Drug monitoring tool
EP3403586A1 (en) 2017-05-18 2018-11-21 Koninklijke Philips N.V. Device and method for determining positioning data for an x-ray image acquisition device on a mobile patient support unit
EP3706720A4 (en) 2017-11-07 2021-08-18 Rani Therapeutics, LLC COAGULATION FACTOR PREPARATIONS TO BE ADMINISTERED INTO INTESTINAL TRACT TISSUE BY MEANS OF A MEDICINAL DELIVERY DEVICE
CN111983071A (zh) * 2020-08-13 2020-11-24 上海交通大学医学院附属上海儿童医学中心 一种末梢微量血维生素d质谱检测方法
CN112433057B (zh) * 2020-11-10 2023-06-09 北京美创新跃医疗器械有限公司 一种狼疮抗凝物的筛选试剂及其制备方法
US20220359068A1 (en) * 2021-05-06 2022-11-10 Propel Technology Services, Inc. Mobile medical system and method

Family Cites Families (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7775976B2 (en) 1920-03-19 2010-08-17 Alere Switzerland Gmbh Method to determine a coagulation property of a fluid
CH478410A (de) 1966-10-11 1969-09-15 Greiner Electronic Ag Verfahren zur Bestimmung der Blutgerinnung
US3695842A (en) 1970-03-12 1972-10-03 Intern Technidyne Corp Method and system for analyzing a liquid
US3890098A (en) 1973-11-16 1975-06-17 Enrique Moreno Machine for the determination of protrombin time and p.t.t.
US3951606A (en) 1974-05-17 1976-04-20 Geomet, Inc. Apparatus for prothrombin testing
US4197734A (en) 1978-07-28 1980-04-15 Alexander Rosenberg Apparatus for determining blood clotting time
US4725554A (en) 1981-06-16 1988-02-16 Hoffmann-La Roche Inc. Method for measuring blood coagulation time
AT382971B (de) 1981-06-16 1987-05-11 Hoffmann La Roche Verfahren und vorrichtung zur messung der blutgerinnungszeit
US4757006A (en) 1983-10-28 1988-07-12 Genetics Institute, Inc. Human factor VIII:C gene and recombinant methods for production
US4965199A (en) 1984-04-20 1990-10-23 Genentech, Inc. Preparation of functional human factor VIII in mammalian cells using methotrexate based selection
DE3516579A1 (de) * 1984-11-19 1986-05-22 Boehringer Mannheim Gmbh, 6800 Mannheim Gerinnungstest auf teststreifen
US4797369A (en) 1985-04-05 1989-01-10 International Technidyne Corp. Method and apparatus for detecting a blood clot
WO1986006101A1 (en) 1985-04-12 1986-10-23 Genetics Institute, Inc. Novel procoagulant proteins
KR910006424B1 (ko) 1985-08-21 1991-08-24 인코텍스 비.브이 편성브리프(brief) 제조방법
DE3785102T2 (de) 1986-01-03 1993-07-22 Genetics Inst Verfahren zur herstellung von faktor-viii:c-typ-proteinen.
US5595886A (en) 1986-01-27 1997-01-21 Chiron Corporation Protein complexes having Factor VIII:C activity and production thereof
US5543502A (en) 1986-06-24 1996-08-06 Novo Nordisk A/S Process for producing a coagulation active complex of factor VIII fragments
US4912040A (en) 1986-11-14 1990-03-27 Genetics Institute, Inc. Eucaryotic expression system
CA1331157C (en) 1987-04-06 1994-08-02 Randal J. Kaufman Method for producing factor viii:c-type proteins
US6060447A (en) 1987-05-19 2000-05-09 Chiron Corporation Protein complexes having Factor VIII:C activity and production thereof
IE69026B1 (en) 1987-06-12 1996-08-07 Immuno Ag Novel proteins with factor VIII activity process for their preparation using genetically-engineered cells and pharmaceutical compositions containing them
US6346513B1 (en) 1987-06-12 2002-02-12 Baxter Trading Gmbh Proteins with factor VIII activity: process for their preparation using genetically-engineered cells and pharmaceutical compositions containing them
DE3720246A1 (de) 1987-06-19 1988-12-29 Behringwerke Ag Faktor viii:c-aehnliches molekuel mit koagulationsaktivitaet
FR2619314B1 (fr) 1987-08-11 1990-06-15 Transgene Sa Analogue du facteur viii, procede de preparation et composition pharmaceutique le contenant
US4994371A (en) 1987-08-28 1991-02-19 Davie Earl W DNA preparation of Christmas factor and use of DNA sequences
DE3837078A1 (de) 1988-10-31 1990-05-03 Holger Behnk Verfahren und vorrichtung zum untersuchen und messen der blutgerinnungszeit
US5004803A (en) 1988-11-14 1991-04-02 Genetics Institute, Inc. Production of procoagulant proteins
US5039617A (en) 1989-04-20 1991-08-13 Biotrack, Inc. Capillary flow device and method for measuring activated partial thromboplastin time
EP0440775B1 (en) * 1989-08-17 1995-08-30 Dade Produktions AG Factor ix chromogenic assay
US6100050A (en) 1989-08-17 2000-08-08 Dade Behring Ag Factor VIII:Ca chromogenic assay
SE465222C5 (sv) 1989-12-15 1998-02-10 Pharmacia & Upjohn Ab Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning
AT395597B (de) 1991-01-25 1993-01-25 Immuno Ag Reagens zur bestimmung von faktor viii-aktivitaet
US6114135A (en) 1991-11-08 2000-09-05 Goldstein; Sheldon Multiple coagulation test system and method of using a multiple coagulation test system
US5859204A (en) 1992-04-07 1999-01-12 Emory University Modified factor VIII
US5364771A (en) 1992-04-07 1994-11-15 Emory University Hybrid human/porcine factor VIII
US6376463B1 (en) 1992-04-07 2002-04-23 Emory University Modified factor VIII
DK0638127T3 (da) 1992-04-27 2000-12-18 Avocet Medical Inc Testartikel og fremgangsmåde til at udføre blodkoagulationsanalyser
US5563045A (en) 1992-11-13 1996-10-08 Genetics Institute, Inc. Chimeric procoagulant proteins
US5302348A (en) 1992-12-10 1994-04-12 Itc Corporation Blood coagulation time test apparatus and method
ATE177536T1 (de) 1993-06-30 1999-03-15 Diagnostische Forsch Stiftung Messung des aktivierten partiellen thromboplastinzeit (aptt) in einer einstufen- reaktion
SE504074C2 (sv) 1993-07-05 1996-11-04 Pharmacia Ab Proteinberedning för subkutan, intramuskulär eller intradermal administrering
US5504011A (en) 1994-10-21 1996-04-02 International Technidyne Corporation Portable test apparatus and associated method of performing a blood coagulation test
SE9503380D0 (sv) 1995-09-29 1995-09-29 Pharmacia Ab Protein derivatives
SI0796623T1 (en) * 1996-03-20 2005-10-31 Baxter Aktiengesellschaft Pharmaceutical preparation for the treatment of blood coagulation disorders
US6458563B1 (en) 1996-06-26 2002-10-01 Emory University Modified factor VIII
CA2225189C (en) 1997-03-06 2010-05-25 Queen's University At Kingston Canine factor viii gene, protein and methods of use
US6046051A (en) 1997-06-27 2000-04-04 Hemosense, Inc. Method and device for measuring blood coagulation or lysis by viscosity changes
US5908786A (en) 1997-12-12 1999-06-01 Akzo Nobel, N.V. Blood coagulation monitoring device with liquid crystal and gradient heater
US6451610B1 (en) 1999-04-14 2002-09-17 International Technidyne Corporation Method and apparatus for coagulation based assays
US6750053B1 (en) 1999-11-15 2004-06-15 I-Stat Corporation Apparatus and method for assaying coagulation in fluid samples
WO2001044493A2 (en) 1999-12-15 2001-06-21 Pentapharm Ag Hematological assay and reagent
WO2002040544A2 (en) 2000-11-14 2002-05-23 Board Of Regents, University Of Texas Systems Mutant human factor ix with an increased resistance to inhibition by heparin
US8110218B2 (en) 2000-11-30 2012-02-07 The Research Foundation Of State University Of New York Compositions and methods for less immunogenic protein-lipid complexes
GB0030929D0 (en) 2000-12-19 2001-01-31 Inverness Medical Ltd Analyte measurement
MXPA04001982A (es) 2001-09-04 2004-06-07 Merck Patent Gmbh Factor ix modificado.
AU2003226027A1 (en) 2002-03-25 2003-10-13 Vector Ii, Inc. System for performing blood coagulation assays and measuring blood clotting times
US7041635B2 (en) 2003-01-28 2006-05-09 In2Gen Co., Ltd. Factor VIII polypeptide
TWI353991B (en) * 2003-05-06 2011-12-11 Syntonix Pharmaceuticals Inc Immunoglobulin chimeric monomer-dimer hybrids
US7348004B2 (en) 2003-05-06 2008-03-25 Syntonix Pharmaceuticals, Inc. Immunoglobulin chimeric monomer-dimer hybrids
ATE497783T1 (de) 2003-05-06 2011-02-15 Syntonix Pharmaceuticals Inc Gerinnungsfaktor vii-fc chimäre proteine zur behandlung von hämostatischen krankheiten
WO2004102202A1 (en) * 2003-05-16 2004-11-25 National Institute For Biological Standards And Control (Nibsc) Activation mixture
US7211559B2 (en) 2003-10-31 2007-05-01 University Of Maryland, Baltimore Factor VIII compositions and methods
US8476234B2 (en) * 2006-02-03 2013-07-02 Prolor Biotech Inc. Long-acting coagulation factors and methods of producing same
EP2423306A1 (en) 2006-06-19 2012-02-29 Catalyst Biosciences, Inc. Modified coagulation factor IX polypeptides and use thereof for treatment
US7700734B2 (en) 2007-01-09 2010-04-20 Shu-Wha Lin Recombinant human factor IX and use thereof
CA2702363A1 (en) 2007-10-15 2009-04-23 The University Of North Carolina At Chapel Hill Human factor ix variants with an extended half life
JP2011517950A (ja) 2008-04-16 2011-06-23 バイエル・ヘルスケア・エルエルシー 第ｉｘ因子の部位特異的修飾
KR20110005862A (ko) 2008-04-16 2011-01-19 바이엘 헬스케어 엘엘씨 변형된 제ｉｘ인자 폴리펩티드 및 이의 용도
US20110137011A1 (en) 2008-04-21 2011-06-09 Novo Nordisk A/S Hyperglycosylated human coagulation factor ix
PL3326643T3 (pl) 2009-12-06 2021-10-25 Bioverativ Therapeutics Inc. Chimeryczne i hybrydowe polipeptydy czynnika VIII-FC oraz sposoby ich zastosowania
WO2012006624A2 (en) 2010-07-09 2012-01-12 Biogen Idec Hemophilia Inc. Factor ix polypeptides and methods of use thereof
EP2737311B1 (en) * 2011-07-25 2020-12-02 Bioverativ Therapeutics Inc. Assays to monitor bleeding disorders
WO2014008480A2 (en) 2012-07-06 2014-01-09 Biogen Idec Ma Inc. Cell line expressing single chain factor viii polypeptides and uses thereof
EP3970738A1 (en) * 2012-07-25 2022-03-23 Bioverativ Therapeutics Inc. Blood factor monitoring assay and uses thereof
CA2888806A1 (en) * 2012-10-18 2014-04-24 Biogen Idec Ma Inc. Methods of using a fixed dose of a clotting factor

Also Published As

Publication number Publication date
US10001495B2 (en) 2018-06-19
WO2014018777A2 (en) 2014-01-30
US20180364263A1 (en) 2018-12-20
EP3970738A1 (en) 2022-03-23
WO2014018777A3 (en) 2014-04-03
US20150185235A1 (en) 2015-07-02
US20220412996A1 (en) 2022-12-29
US11372008B2 (en) 2022-06-28
EP2877202A4 (en) 2016-06-01
EP2877202A2 (en) 2015-06-03

Similar Documents

Publication Publication Date Title
HK1212882A1 (zh) 血液因子的監測分析及其用途
EP2812661A4 (en) SYSTEM FOR MONITORING A STRUCTURAL INTEGRITY AND USE WITH ADJUSTABLE FREQUENCY
HK1209413A1 (zh) 新的 -氨基四氫喹啉- -羧酸及其用途
HK1199023A1 (zh) 取代的苯並噻吩基-吡咯並三嗪及其用途
HK1202545A1 (zh) 新型二氮雜螺環烷烴和氮雜螺環烷烴
HK1203493A1 (zh) 取代的氮雜雙環及其用途
SG11201407099WA (en) Anti-pcsk9 antibodies and use thereof
HK1200822A1 (zh) 取代的聯吡啶胺及其用途
HK1213455A1 (zh) 醫療用緊固件
HK1210949A1 (zh) 組合及其用途
GB201217770D0 (en) Biological probes and the use thereof
EP2814409A4 (en) ULTRASOUND TREATMENT AND MONITORING WITH INCREASED REFLECTION
EP2875014A4 (en) ANTI-MUCUS MEDICAMENTS AND USES THEREOF
HK1212390A1 (zh) 試驗方法和系統
HUE037075T2 (hu) Retinoidok és alkalmazásuk
HK1203198A1 (zh) 取代的苯基咪唑並吡唑及其用途
HK1207309A1 (zh) 抗托法替尼抗體及其用於藥物監測的用途
HK1210809A1 (zh) β己糖基轉移酶及其用法
HK1207154A1 (zh) -脂聯素複合物及其用途
GB201216381D0 (en) New compounds and medical uses
GB201208970D0 (en) New compounds and medical uses
AP2015008228A0 (en) Novel 5-aminotetrahydroquinoline-2-carboxylic acids and use thereof
GB201201055D0 (en) Detection device and assay